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https://www.readbyqxmd.com/read/29145242/the-association-of-genetic-variants-in-chemokine-genes-with-the-risk-of-psoriasis-vulgaris-in-chinese-population-a-case-control-study
#1
Jin Zhang, Qiuhe Song, Kun Zhu, Jun Lu, Xiaogang Xiong, Fei Hao
This study aimed to investigate the influence of polymorphisms in chemokine genes, including MCP1, CCR2, and CCR5 with psoriasis vulgaris (PV) risk in a Chinese population.The genotyping of studied polymorphisms through polymerase chain reaction (PCR) and sequencing was conducted in 142 PV patients and 147 healthy controls. The genotype distribution of the polymorphisms in the control group was checked to determine whether it conformed to Hardy-Weinberg equilibrium (HWE). The genotype and allele frequencies were compared between PV patients and the healthy controls using Chi-square test...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145205/decline-in-search-speed-and-verbal-memory-over-26-years-of-midlife-in-a-british-birth-cohort
#2
Daniel Davis, Rebecca Bendayan, Graciela Muniz Terrera, Rebecca Hardy, Marcus Richards, Diana Kuh
BACKGROUND: Cognitive capabilities change in later life, although their onset and rate of decline, and how they are shaped by lifetime socioeconomic position, childhood cognition and adult health status are all unclear. METHODS: From the Medical Research Council National Survey of Health and Development, we analysed 3,192 participants undergoing one or more cognitive assessments at ages 43, 53, 60-64 and 69. Linear mixed models described cognitive trajectories, adjusting for factors across the life course...
November 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29144995/content-analysis-of-homeless-smokers-perspectives-on-established-and-alternative-smoking-interventions
#3
Susan E Collins, Victoria E Orfaly, Teresa Wu, Sunny Chang, Robert V Hardy, Amia Nash, Matthew B Jones, Leslie Mares, Emily M Taylor, Lonnie A Nelson, Seema L Clifasefi
BACKGROUND: Cigarette smoking is 5 times more prevalent among homeless individuals than in the general population, and homeless individuals are disproportionately affected by smoking-related morbidity and mortality. Homeless smokers report interest in changing their smoking behavior; however, established smoking cessation interventions are neither desirable to nor highly effective for most members of this population. The aim of this study was to document homeless smokers' perceptions of established smoking interventions as well as self-generated, alternative smoking interventions to elucidate points for intervention enhancement...
November 13, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29143602/molecular-and-agro-morphological-characterization-of-ancient-wheat-landraces-of-turkey
#4
Kahraman Gurcan, Fatih Demirel, Mehmet Tekin, Serap Demirel, Taner Akar
BACKGROUND: Turkey is one of the important gene centers for many crop species. In this research, some ancient wheats such as tetraploid and diploid hulled wheats together with hexaploid tir wheats (Triticum aestivum ssp. leucospermum Korn.) landraces mainly adapted to harsh winter conditions of Eastern Anatolian region of Turkey were characterized at agro-morphological and molecular level. Totally 50 hulled wheat population from Kastamonu, Konya and Kayseri provinces and 15 tir wheats from Kars provinces of Turkey were in-situ collected for characterization in 2013...
November 14, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29141605/an-intronic-single-nucleotide-polymorphism-rs13217795-in-foxo3-is-associated-with-asthma-and-allergic-rhinitis-a-case-case-control-study
#5
Justin Z Amarin, Randa G Naffa, Haya H Suradi, Yousof M Alsaket, Nathir M Obeidat, Tareq M Mahafza, Malek A Zihlif
BACKGROUND: Asthma and allergic rhinitis are respiratory diseases with a significant global burden. Forkhead box O3 (FOXO3) is a gene involved in the etiology of a number of respiratory diseases. The objective of this study is to assess the association of rs13217795, an intronic FOXO3 single-nucleotide polymorphism, with asthma and allergic rhinitis. METHODS: In this case-case-control genetic association study, genotyping was conducted using the PCR-RFLP method...
November 15, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29141403/lipogels-for-encapsulation-of-hydrophilic-proteins-and-hydrophobic-small-molecules
#6
Celia C Homyak, Ann Fernandez, Mollie A Touve, Bo Zhao, Francesca Anson, Jeanne A Hardy, Richard W Vachet, Nathan C Gianneschi, Jennifer L Ross, S Thayumanavan
Lipid-polymer hybrid materials have the potential to exhibit enhanced stability and loading capabilities in comparison to parent liposome or polymer materials. However, complexities lie in formulating and characterizing such complex nanomaterials. Here we describe a lipid-coated polymer gel (lipogel) formulated using a one-pot methodology, where self-assembling liposomes template a UV-curable polymer gel core. Using fluorescently-labeled lipids, protein, and hydrophobic molecules, we have characterized their formation, purification, stability, and encapsulation efficiency via common instrumentation methods such as dynamic light scattering (DLS), matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS), UV-Visible spectroscopy, fluorescence spectroscopy, and single particle total internal reflection fluorescence (TIRF) microscopy...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29141374/-association-of-pd-1-tim-3-and-trem-1-single-nucleotide-polymorphisms-with-pulmonary-tuberculosis-susceptibility
#7
F M Wang, X Zhang, L Lan, J M Ji, H B Tang, X J Yao, Y Jiang, J Qian, X G Xu, Q Li, P Yao, J H Li, Y P Shen
Objective: To investigate the association of programmed cell death 1(PD-1), T cell immunoglobulin mucin 3 (TIM-3) and triggering receptor expressed on myeloid cells-1 (TREM-1) genes polymorphisms with pulmonary tuberculosis susceptibility. Methods: In this case-control study, peripheral venous blood of 100 pulmonary tuberculosis patients (pulmonary tuberculosis group) in the Jintan People's Hospital of Changzhou and of community physical examination volunteers (health control group) was collected from Mar 2015 to Sep 2016...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29140272/an-investigation-of-polyoxometalate-hybrid-materials-as-patternable-dielectrics-and-lithographic-resists
#8
Brandon Hardie, Mark Roll
Polyoxometalate (POM) hybrid materials have shown potential as spin-coatable, patternable dielectric thin-films and components for lithographic resists. In particular, the octamolybdate cluster has been shown to possess good spin-coating properties and the patterning capabilities of hybrid octamolybdate thin-films were explored using a combination of broadband UV and electron beam lithography (EBL) techiniques. Dielectric properties of these films were determined by ellipsometry, and octamolybdate clusters were subsequently investigated as negative resists in various blends for potential uses in next-generation photolithography, where contrast, sensitivity, and line edge roughness characteristics were determined...
November 15, 2017: Materials
https://www.readbyqxmd.com/read/29137376/impact-of-vegfa-polymorphisms-on-glioma-risk-in-chinese
#9
Peng Zhao, Anjing Chen, Qichao Qi, Wenjing Zhou, Zichao Feng, Jiwei Wang, Ning Yang, Xingang Li, Jian Wang, Qibing Huang, Bin Huang
Several single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor A (VEGFA) gene have been previously reported to be associated with glioma susceptibility, but individual studies have demonstrated inconclusive results. In the current study, a meta-analysis was performed to derive a more precise estimation of the involvement of VEGFA polymorphisms in glioma development. A comprehensive literature search conducted in PubMed, Embase, the Cochrane Library, and OVID databases through February 25, 2017 yielded 4 eligible studies consisting of 2,275 cases and 2,475 controls...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136485/evaluating-the-impact-of-training-in-obesity-prevention-methods-on-the-counseling-knowledge-and-skills-of-wic-nutritionists-in-georgia-2014-2015
#10
Wendy Palmer, Danielle Henderson, Barbara Stahnke, Katherine Shary, Trisha Hardy, Jean A Welsh
OBJECTIVES: Motivational interviewing, a client-centered intervention method focused on enhancing intrinsic motivation for behavior change, shows a positive impact on children's weight status (ie, stabilizing or slowing down weight gain as a child grows). We evaluated the impact of a training program on knowledge and adoption of evidence-based obesity prevention counseling strategies among counselors from Georgia's Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)...
November 2017: Public Health Reports
https://www.readbyqxmd.com/read/29136484/effect-of-the-strong4life-school-nutrition-program-on-cafeterias-and-on-manager-and-staff-member-knowledge-and-practice-georgia-2015
#11
Janani Rajbhandari-Thapa, Ashley Bennett, Farrah Keong, Wendy Palmer, Trisha Hardy, Jean Welsh
OBJECTIVES: The goal of the Strong4Life School Nutrition Program is to promote healthy eating in school cafeterias in Georgia by training school nutrition managers and staff members to implement changes in the cafeteria to nudge children to make healthier choices. The objective of our study was to evaluate program effect on (1) school nutrition manager and staff member knowledge of evidence-based strategies and their self-efficacy to make positive changes, (2) the school cafeteria environment, and (3) National School Lunch Program participation...
November 2017: Public Health Reports
https://www.readbyqxmd.com/read/29136357/association-of-cytokine-gene-polymorphisms-with-bronchopulmonary-dysplasia-in-han-chinese-newborns
#12
Hui Chen, Wei Zheng
OBJECTIVE: To investigate the association of 14 cytokine gene polymorphisms with bronchopulmonary dysplasia (BPD) among Han Chinese newborns. The 14 polymorphisms investigated were IL18 rs1946519, rs1946518, rs187238, rs360718, and rs360717 polymorphisms, IL10 rs3024493 polymorphism, IL6 rs1800795, rs1800796, and rs1800797 polymorphisms, TNF rs361525 and rs1800629 polymorphisms, and TGFB1 rs1800469, rs1800468, and rs1800471 polymorphisms. WORKING HYPOTHESIS: The polymorphisms could be associated with the risk of BPD among Han Chinese newborns...
November 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29134366/genetic-characteristics-of-19-strs-in-chinese-uzbek-ethnic-and-its-phylogenetic-relationships-with-other-24-populations
#13
Xiaoye Jin, Wei Cui, Yuanyuan Wei, Yuling Mu, Qian Dong, Chong Chen, Yuxin Guo, Tingting Kong, Bofeng Zhu, Jiangang Chen
Allelic frequencies and genetic polymorphisms of 19 short tandem repeats loci were investigated so as to provide more genetic data for forensic applications in Chinese Uzbek group; besides, we evaluated phylogenetic relationships of Uzbek group with other populations. All loci were observed to conform to Hardy-Weinberg equilibrium after Bonferroni's correction. Two hundred and nine alleles were identified in 212 unrelated healthy Uzbek individuals and their allelic frequencies ranged from 0.0024 to 0.5259. The cumulative discrimination power and cumulative probability of exclusion were 0...
November 14, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29134069/engaging-rural-australian-communities-in-national-science-week-helps-increase-visibility-for-women-researchers
#14
Margaret C Hardy, Mathilde R Desselle
During a week-long celebration of science, run under the federally supported National Science Week umbrella, the Catch a Rising Star: women in Queensland research (CaRS) programme flew scientists who identify as women to nine regional and remote communities in the Australian State of Queensland. The aim of the project was twofold: first, to bring science to remote and regional communities in a large, economically diverse state; and second, to determine whether media and public engagement provides career advancement opportunities for women scientists...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133992/five-new-species-of-the-armored-scale-genus-andaspis-macgillivray-hemiptera-coccomorpha-diaspididae-from-new-caledonia
#15
Fredericka B Hamilton, Douglas J Williams, Nate B Hardy
New Caledonia is home to many endemic species of plants and animals. Here, we improve our grasp on that biota by describing five new species of armored scale insects in the genus Andaspis: Andaspis brevicornutasp. n, A. conicasp. n., A. nothofagisp. n., A. novaecaledoniaesp. n., and A. ornatasp. n. Each is known exclusively from collections on southern beeches (Nothofagus spp.) in New Caledonia. A key to the species of Andaspis of New Caledonia is provided.
2017: ZooKeys
https://www.readbyqxmd.com/read/29133590/genotoxic-damage-activates-the-ampk-%C3%AE-1-isoform-in-the-nucleus-via-ca2-camkk2-signaling-to-enhance-tumor-cell-survival
#16
Diana Vara Ciruelos, Madhumita Dandapani, Alexander Gray, Ejaife O Egbani, A Mark Evans, D Grahame Hardie
Many genotoxic cancer treatments activate AMP-activated protein kinase (AMPK), but the mechanisms of AMPK activation in response to DNA damage, and its downstream consequences, have been unclear. In this study, etoposide activates the α1 but not the α2 isoform of AMPK, primarily within the nucleus. AMPK activation is independent of ataxia-telangiectasia mutated (ATM), a DNA damage-activated kinase, and the principal upstream kinase for AMPK, LKB1, but correlates with increased nuclear Ca2+ and requires the Ca2+/calmodulin-dependent kinase, CaMKK2...
November 13, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29130768/screening-of-six-polymorphisms-related-with-folate-metabolism-in-parents-of-individuals-with-down-syndrome
#17
Marly Balarin, Mariângela Cintra, Fernanda Cordeiro, Lucila Naves, Roseane Silva-Grecco
OBJECTIVE: The study aim to investigate MTHFR C677T, MTHFR A1298C, RFC1 A80G, MTR A2756G, CBS 844ins68, MTRR A66G polymorphisms in Down syndrome (DS) parents. METHODS: Polymorphisms were evaluated in 35 mothers and 24 fathers of individuals with free trisomy of chromosome 21 confirmed by karyotype. The control group included 26 mothers and 26 fathers who had no children with DS. The molecular analysis was performed by Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) (Reaction Chain Polymerase Restriction Fragment Length Polymorphism) or Polymerase Chain Reaction (PCR)...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29129742/the-sequence-preference-of-dna-cleavage-by-t4-endonuclease-vii
#18
Megan E Hardie, Vincent Murray
The enzyme T4 endonuclease VII is a resolvase that acts on branched DNA intermediates during genetic recombination, by cleaving DNA with staggered cuts approximately 3-6 bp apart. In this paper, we investigated the sequence preference of this cleavage reaction utilising two different DNA sequences. For the first time, the DNA sequence preference of T4 endonuclease VII cleavage sites has been examined without the presence of a known DNA substrate to mask any inherent nucleotide preference. The use of the ABI3730 platform enables the cleavage site to be determined at nucleotide resolution...
November 9, 2017: Biochimie
https://www.readbyqxmd.com/read/29129009/irak2-is-associated-with-susceptibility-to-rheumatoid-arthritis
#19
Hana Ben Hassine, Rim Sghiri, Elyes Chabchoub, Asma Boumiza, Foued Slama, Khadija Baccouche, Zahid Shakoor, Adel Almogren, Christina Mariaselvam, Ryad Tamouza, Elyes Bouajina, Ramzi Zemni
This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA). IRAK2 rs3844283 and rs708035genotyping was determined by mutagenically separated PCR with specifically designed primers in a cohort of 222 (30 men, 192 women, mean age 49 years) adult RA patients and 224 matched controls. IRAK2 rs3844283 C allele was detected in 66% of RA patients and 74% of controls. The CC genotype was the most frequent genotype in both RA patients (45...
November 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29127876/differentiating-biliary-cystadenomas-from-benign-hepatic-cysts-preliminary-analysis-of-new-predictive-imaging-features
#20
Mark D Kovacs, Douglas H Sheafor, Philip F Burchett, Melissa M Picard, Andrew D Hardie
OBJECTIVE: To identify performance of imaging features in differentiating hepatic cysts from biliary cystadenomas of the liver. METHODS: 25 pathologically confirmed hepatic cystic lesions (hepatic cysts or biliary cystadenomas) were evaluated retrospectively and predetermined imaging features assessed for performance in differentiation. RESULTS: Any septation which arose from a cyst wall without external indentation had a very high association with biliary cystadenoma, while the presence of a thick septation had only a moderate association...
November 3, 2017: Clinical Imaging
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