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https://www.readbyqxmd.com/read/27922445/letter-to-the-editor-obesity-severity-and-duration-are-associated-with-incident-metabolic-syndrome-evidence-against-metabolically-healthy-obesity-from-the-multi-ethnic-study-of-atherosclerosis
#1
Wahyu Wulaningsih, Johnathan Watkins, Rebecca Hardy
No abstract text is available yet for this article.
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27920783/genomic-tools-in-pearl-millet-breeding-for-drought-tolerance-status-and-prospects
#2
REVIEW
Desalegn D Serba, Rattan S Yadav
Pearl millet [Penisetum glaucum (L) R. Br.] is a hardy cereal crop grown in the arid and semiarid tropics where other cereals are likely to fail to produce economic yields due to drought and heat stresses. Adaptive evolution, a form of natural selection shaped the crop to grow and yield satisfactorily with limited moisture supply or under periodic water deficits in the soil. Drought tolerance is a complex polygenic trait that various morphological and physiological responses are controlled by 100s of genes and significantly influenced by the environment...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27920291/teaching-neuroimages-nonfluent-variant-primary-progressive-aphasia-a-distinctive-clinico-anatomical-syndrome
#3
Charles R Marshall, Christopher J D Hardy, Martin N Rossor, Jason D Warren
No abstract text is available yet for this article.
December 6, 2016: Neurology
https://www.readbyqxmd.com/read/27918778/efficacy-of-oral-risperidone-haloperidol-or-placebo-for-symptoms-of-delirium-among-patients-in-palliative-care-a-randomized-clinical-trial
#4
Meera R Agar, Peter G Lawlor, Stephen Quinn, Brian Draper, Gideon A Caplan, Debra Rowett, Christine Sanderson, Janet Hardy, Brian Le, Simon Eckermann, Nicola McCaffrey, Linda Devilee, Belinda Fazekas, Mark Hill, David C Currow
Importance: Antipsychotics are widely used for distressing symptoms of delirium, but efficacy has not been established in placebo-controlled trials in palliative care. Objective: To determine efficacy of risperidone or haloperidol relative to placebo in relieving target symptoms of delirium associated with distress among patients receiving palliative care. Design, Setting, and Participants: A double-blind, parallel-arm, dose-titrated randomized clinical trial was conducted at 11 Australian inpatient hospice or hospital palliative care services between August 13, 2008, and April 2, 2014, among participants with life-limiting illness, delirium, and a delirium symptoms score (sum of Nursing Delirium Screening Scale behavioral, communication, and perceptual items) of 1 or more...
December 5, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27917986/the-cultural-heritage-of-pastoralism-local-knowledge-state-identity-and-the-global-perspective-the-example-of-local-breeds-in-morocco
#5
Y Ben Hounet, A-M Brisebarre, S Guinand
Over the past few decades, the heritage designation process has come to impact on the way of life of many nomadic pastoralists across the world. Since the Convention Concerning the Protection of the World Cultural and Natural Heritage was adopted in 1972, policies for the conservation of protected areas have been implemented under the aegis of the United Nations Educational, Scientific and Cultural Organization (UNESCO), especially in countries of the South, with a varying impact on the practices and perceptions of pastoral communities...
November 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/27917334/genetic-association-between-tnf-%C3%AE-857-c-t-polymorphism-and-ankylosing-spondylitis-susceptibility-evidence-from-a-meta-analysis
#6
Yong Li, Hong-Bo Tang, Jing Bian, Bin-Bin Li, Tai-Fang Gong
Certain studies have suggested that the tumor necrosis factor-α (TNF-α) -857 C/T polymorphism is associated with risk of ankylosing spondylitis. However, the conclusions remain controversial. Therefore, we performed a meta-analysis to provide a more precise conclusion. Such databases as PubMed, Embase, CBM, CNKI, and Wanfang Data were searched to identify relevant studies up to August 26, 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between TNF-α -857 C/T polymorphism and ankylosing spondylitis susceptibility...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27914610/lack-of-association-between-vitamin-d-receptor-polymorphisms-apai-rs7975232-and-bsmi-rs1544410-and-osteoporosis-among-the-han-chinese-population-a-meta-analysis
#7
Meng Yu, Guo-Qiang Chen, Fang Yu
In this study, we aimed to assess the relationship between vitamin D receptor gene polymorphisms and osteoporosis in the Han Chinese population. Articles regarding associations between vitamin D receptor polymorphisms (ApaI rs7975232 and BsmI rs1544410) and osteoporosis were retrieved from databases in November 2014. Eligible studies were tested by the Hardy-Weinberg equilibrium. The odds ratio and 95% confidence interval (95% CI) were analyzed to evaluate the strength of the associations. Pooled effect estimates were derived using a fixed-effect model and a random-effect model according to the heterogeneity of the test results...
December 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27914594/association-of-pdcd1-polymorphism-to-systemic-lupus-erythematosus-and-rheumatoid-arthritis-susceptibility
#8
Luisa Matos do Canto, Ticiana Della Justina Farias, Mayara Delagnelo Medeiros, Cíntia Callegari Coêlho, Aline Fernanda Rodrigues Sereia, Lia Kubelka Fernandes de Carlos Back, Filipe Martins de Mello, Adriana Fontes Zimmermann, Ivânio Alves Pereira, Ilíada Rainha de Souza
OBJECTIVE: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy-Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0...
November 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27914261/reducing-implant-loss-rates-in-immediate-breast-reconstructions
#9
L Darragh, A Robb, C M Hardie, S McDonald, P Valand, J M O'Donogue
UK best practice guidelines for oncoplastic breast reconstruction were published in 2012. Implant-based reconstruction quality indicator (QI) targets for readmission, return to theatre and implant loss rates were set at 5% by 3 months, along with guidance to achieve these targets. The aims of this study were to quantify complication rates following implant-based reconstruction before and after the implementation of the guidelines. A retrospective audit of 86 patients with 106 implants in the 12 months to June 2013 was performed, C1...
November 30, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27913796/a-randomized-controlled-trial-of-assisted-intention-monitoring-for-the-rehabilitation-of-executive-impairments-following-acquired-brain-injury
#10
Fergus Gracey, Jessica E Fish, Eve Greenfield, Andrew Bateman, Donna Malley, Gemma Hardy, Jessica Ingham, Jonathan J Evans, Tom Manly
BACKGROUND: Acquired brain injury (ABI) can impair executive function, impeding planning and attainment of intentions. Research shows promise for some goal-management rehabilitation interventions. However, evidence that alerts assist monitoring and completion of day-to-day intentions is limited. OBJECTIVE: To examine the efficacy of brief goal-directed rehabilitation paired with periodic SMS text messages designed to enhance executive monitoring of intentions (assisted intention monitoring [AIM])...
December 2, 2016: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/27913428/migration-pathways-of-thalamic-neurons-and-development-of-thalamocortical-connections-in-humans-revealed-by-diffusion-mr-tractography
#11
Molly Wilkinson, Tara Kane, Rongpin Wang, Emi Takahashi
The thalamus plays an important role in signal relays in the brain, with thalamocortical (TC) neuronal pathways linked to various sensory/cognitive functions. In this study, we aimed to see fetal and postnatal development of the thalamus including neuronal migration to the thalamus and the emergence/maturation of the TC pathways. Pathways from/to the thalami of human postmortem fetuses and in vivo subjects ranging from newborns to adults with no neurological histories were studied using high angular resolution diffusion MR imaging (HARDI) tractography...
December 2, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27913383/traumatic-haemopneumothorax-and-whole-body-subcutaneous-emphysema-successful-use-of-a-small-bore-chest-drain
#12
Benjamin Hardy, Nicholas Sunderland, Mevan Perera, Kathryn Channing
A 56-year-old man presented having had two falls at home. He had a background of multiple sclerosis. After his second fall, during which he had fallen onto the toilet injuring his right chest, he was brought into the emergency department reporting pleuritic chest discomfort. Immediately evident was extensive swelling from his forehead to his thighs, which on palpation was found to be subcutaneous emphysema. A chest X-ray showed a large right-sided pneumothorax for which a chest drain was inserted. A CT revealed extensive surgical emphysema, pneumomediastinum, pneumoperitoneum and gas within the spinal canal...
December 2, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27913309/sequence-determinants-of-the-caenhorhabditis-elegansdopamine-transporter-dictating-in-vivoaxonal-export-and-synaptic-localization
#13
Sarah B Robinson, J Andrew Hardaway, Shannon L Hardie, Jane Wright, Ryan M Glynn, Daniel P Bermingham, Qiao Han, Sarah M Sturgeon, Phyllis Freeman, Randy D Blakely
The monoamine neurotransmitter dopamine (DA) acts across phylogeny to modulate both simple and complex behaviors. The presynaptic DA transporter (DAT) is a major determinant of DA signaling capacity in ensuring efficient extracellular DA clearance. In humans, DAT is also a major target for prescribed and abused psychostimulants. Multiple structural determinants of DAT function and regulation have been defined, though largely these findings have arisen from heterologous expression or ex vivo cell culture studies...
November 29, 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27913155/early-molecular-stratification-of-high-risk-primary-biliary-cholangitis
#14
Claire Hardie, Kile Green, Laura Jopson, Ben Millar, Barbara Innes, Sarah Pagan, Dina Tiniakos, Jessica Dyson, Muzlifah Haniffa, Venetia Bigley, David E Jones, John Brain, Lucy J Walker
High-risk primary biliary cholangitis (PBC), defined by inadequate response at one year to Ursodeoxycholic acid (UDCA), is associated with disease progression and liver transplantation. Stratifying high-risk patients early would facilitate improved approaches to care. Using long-term follow-up data to define risk at presentation, 6 high-risk PBC patients and 8 low-risk patients were identified from biopsy, transplant and biochemical archival records. Formalin-fixed paraffin-embedded (FFPE) liver biopsies taken at presentation were graded (Scheuer and Nakanuma scoring) and gene expression analysed using the NanoString® nCounter PanCancer Immunity 770-gene panel...
November 21, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27912796/staphylococcal-species-heterogeneity-in-the-nasal-microbiome-following-antibiotic-prophylaxis-revealed-by-tuf-gene-deep-sequencing
#15
Claire L McMurray, Katherine J Hardy, Szymon T Calus, Nicholas J Loman, Peter M Hawkey
BACKGROUND: Staphylococci are a major constituent of the nasal microbiome and a frequent cause of hospital-acquired infection. Antibiotic surgical prophylaxis is administered prior to surgery to reduce a patient's risk of postoperative infection. The impact of surgical prophylaxis on the nasal staphylococcal microbiome is largely unknown. Here, we report the species present in the nasal staphylococcal microbiome and the impact of surgical prophylaxis revealed by a novel culture independent technique...
December 2, 2016: Microbiome
https://www.readbyqxmd.com/read/27911669/bidirectional-relations-between-different-forms-of-prosocial-behaviors-and-substance-use-among-female-college-student-athletes
#16
Alexandra N Davis, Gustavo Carlo, Sam Hardy, Janine Olthius, Byron L Zamboanga
Bidirectional, longitudinal relations between alcohol and marijuana use and prosocial behaviors in women college student athletes were examined. Participants were 187 female college students (Mage = 19.87 years; 91% White) who completed questionnaires on their use of marijuana and alcohol, and six forms of prosocial behaviors across 6 years (2004-2010). The findings yield overall evidence that earlier marijuana use predicted lower levels of most specific forms of prosocial behaviors for women athletes in later young adulthood...
December 2, 2016: Journal of Social Psychology
https://www.readbyqxmd.com/read/27911417/plasma-assisted-molecular-beam-epitaxy-of-n-polar-inaln-barrier-high-electron-mobility-transistors
#17
Matthew T Hardy, David F Storm, D Scott Katzer, Brian P Downey, Neeraj Nepal, David J Meyer
Plasma-assisted molecular beam epitaxy is well suited for the epitaxial growth of III-nitride thin films and heterostructures with smooth, abrupt interfaces required for high-quality high-electron-mobility transistors (HEMTs). A procedure is presented for the growth of N-polar InAlN HEMTs, including wafer preparation and growth of buffer layers, the InAlN barrier layer, AlN and GaN interlayers and the GaN channel. Critical issues at each step of the process are identified, such as avoiding Ga accumulation in the GaN buffer, the role of temperature on InAlN compositional homogeneity, and the use of Ga flux during the AlN interlayer and the interrupt prior to GaN channel growth...
November 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910418/observation-of-hohlraum-wall-motion-with-spectrally-selective-x-ray-imaging-at-the-national-ignition-facility
#18
N Izumi, N B Meezan, L Divol, G N Hall, M A Barrios, O Jones, O L Landen, J J Kroll, S A Vonhof, A Nikroo, J Jaquez, C G Bailey, C M Hardy, R B Ehrlich, R P J Town, D K Bradley, D E Hinkel, J D Moody
The high fuel capsule compression required for indirect drive inertial confinement fusion requires careful control of the X-ray drive symmetry throughout the laser pulse. When the outer cone beams strike the hohlraum wall, the plasma ablated off the hohlraum wall expands into the hohlraum and can alter both the outer and inner cone beam propagations and hence the X-ray drive symmetry especially at the final stage of the drive pulse. To quantitatively understand the wall motion, we developed a new experimental technique which visualizes the expansion and stagnation of the hohlraum wall plasma...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910303/improving-a-high-efficiency-gated-spectrometer-for-x-ray-thomson-scattering-experiments-at-the-national-ignition-facility
#19
T Döppner, D Kraus, P Neumayer, B Bachmann, J Emig, R W Falcone, L B Fletcher, M Hardy, D H Kalantar, A L Kritcher, O L Landen, T Ma, A M Saunders, R D Wood
We are developing x-ray Thomson scattering for applications in implosion experiments at the National Ignition Facility. In particular we have designed and fielded MACS, a high-efficiency, gated x-ray spectrometer at 7.5-10 keV [T. Döppner et al., Rev. Sci. Instrum. 85, 11D617 (2014)]. Here we report on two new Bragg crystals based on Highly Oriented Pyrolytic Graphite (HOPG), a flat crystal and a dual-section cylindrically curved crystal. We have performed in situ calibration measurements using a brass foil target, and we used the flat HOPG crystal to measure Mo K-shell emission at 18 keV in 2nd order diffraction...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909914/association-of-snp-variants-of-mhc-class-ii-drb-gene-with-thermo-physiological-traits-in-tropical-goats
#20
Abdulmojeed Yakubu, Adebowale E Salako, Marcos De Donato, Sunday O Peters, Michael I Takeet, Mathew Wheto, Moses Okpeku, Ikhide G Imumorin
Host defense in vertebrates depend on many secreted regulatory proteins such as major histocompatibility complex (MHC) class II which provide important regulatory and effector functions of T cells. Gene polymorphism in the second exon of Capra-DRB gene in three major Nigerian goat breeds [West African Dwarf (WAD), Red Sokoto (RS), and Sahel (SH)] was analyzed by restriction fragment length polymorphisms (RFLP). Four restriction enzymes, BsaHI, AluI, HaeIII, and SacII, were utilized. The association between the polymorphic sites and some heat tolerance traits were also investigated in a total of 70 WAD, 90 RS, and 50 SH goats...
December 1, 2016: Tropical Animal Health and Production
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