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D V Scholey, N K Morgan, A Riemensperger, R Hardy, E J Burton
There has been discussion regarding microbial phytase replacing inorganic phosphorus (P) supplementation in broiler diets. Therefore, an experiment was conducted to examine the effect of phytase supplementation on diets low in inorganic P. Ross 308 broilers (n = 288) were fed one of 6 experimental diets in 4 phases. The control diet had 16.20, 10.90, 9.40, and 6.10 g/kg inorganic P in the Starter, Grower 1, Grower 2 and Finisher phase respectively. The remaining diets had 10.50 g/kg inorganic P in the Starter phase...
March 16, 2018: Poultry Science
Amelia R I Lindsey, Tamanash Bhattacharya, Irene L G Newton, Richard W Hardy
At the forefront of vector control efforts are strategies that leverage host-microbe associations to reduce vectorial capacity. The most promising of these efforts employs Wolbachia , a maternally transmitted endosymbiotic bacterium naturally found in 40% of insects. Wolbachia can spread through a population of insects while simultaneously inhibiting the replication of viruses within its host. Despite successes in using Wolbachia -transfected mosquitoes to limit dengue, Zika, and chikungunya transmission, the mechanisms behind pathogen-blocking have not been fully characterized...
March 21, 2018: Viruses
Yun Tae Hwang, Lorenzo Rocchi, Paul Hammond, Chris Jd Hardy, Jason D Warren, Basil H Ridha, John Rothwell, Martin N Rossor
Introduction: There is a need for a reliable, noninvasive biomarker for Alzheimer's disease (AD). We assessed whether short-latency afferent inhibition (SAI), a transcranial magnetic stimulation paradigm that assesses cholinergic circuits of the brain, could become such a biomarker. Methods: Nineteen patients with AD underwent four SAI testing sessions. The timing of their usual donepezil dose was altered to create different cholinergic states for each session. This was compared to the SAI results from 20 healthy subjects...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Yan Yan, Ai-Ping Deng, Wen Chen, Yu-Hua Ming, Xian-Tao Zeng, Wei-Dong Leng
Background: The human 8-oxoguanine glycosylase 1 ( hOGG1 ) Ser326Cys polymorphism has been involved in the risk of head and neck squamous cell carcinoma (HNSCC), but the results of published studies on this topic still inconsistent. Results: Finally 11 qualified publications with 13 independent case-control studies were yielded. Overall, we observed significant differences in CysCys vs. SerSer [odds ratio (OR) = 1.55, 95% confidence interval (95% CI) = 1.01-2.38] and CysCys vs...
February 27, 2018: Oncotarget
Omar Abidi, Mohammed Haissam, Halima Nahili, Abdessamad El Azhari, Said Hilmani, Abdelhamid Barakat
BACKGROUND: The number of deaths from hemorrhagic strokes is about twice as high than the number of deaths from ischemic strokes. Genetic risk assessment could play important roles in preventive and therapeutic strategies. The present study was aimed to evaluate whether the MTHFR gene polymorphisms could increase the risk of cerebral hemorrhage in Moroccan patients. METHODS: A total of 113 patients with hemorrhagic stroke and 323 healthy controls were included in this case-control study...
March 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Safwat Y Diab, Sanna Isosävi, Samir R Qouta, Saija Kuittinen, Raija-Leena Punamäki
BACKGROUND: Women at pre partum and post partum are especially susceptible to war trauma because they struggle to protect their infants from danger. Trauma research suggests increased problems in maternal mental health and infant development. Yet many cognitive-emotional processes affect the trauma survivors' mental health, such as post-traumatic growth and post-traumatic cognition. The aim of this study was to examine whether a mother's high post-traumatic growth and optimal post-traumatic cognition could protect their own mental health and their infant's stress regulation from the effects of traumatic war experiences...
February 21, 2018: Lancet
Nurgul Sikhayeva, Yerkebulan Talzhanov, Aisha Iskakova, Jarkyn Dzharmukhanov, Raushan Nugmanova, Elena Zholdybaeva, Erlan Ramanculov
Background: Ethnic differences exist in the frequencies of genetic variations that contribute to the risk of common disease. This study aimed to analyse the distribution of several genes, previously associated with susceptibility to type 2 diabetes and obesity-related phenotypes, in a Kazakh population. Methods: A total of 966 individuals belonging to the Kazakh ethnicity were recruited from an outpatient clinic. We genotyped 41 common single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes in other ethnic groups and 31 of these were in Hardy-Weinberg equilibrium...
2018: Clinical Interventions in Aging
Jing Dong, David M Levine, Matthew F Buas, Rui Zhang, Lynn Onstad, Rebecca C Fitzgerald, Douglas A Corley, Nicholas J Shaheen, Jesper Lagergren, Laura J Hardie, Brian J Reid, Prasad G Iyer, Harvey A Risch, Carlos Caldas, Isabel Caldas, Paul D Pharoah, Geoffrey Liu, Marilie D Gammon, Wong-Ho Chow, Leslie Bernstein, Nigel C Bird, Weimin Ye, Anna H Wu, Lesley A Anderson, Stuart MacGregor, David C Whiteman, Thomas L Vaughan, Aaron P Thrift
BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for esophageal adenocarcinoma (EA) and Barrett's esophagus (BE). However, variants in these loci account for a small fraction of cases of EA and BE. Genetic factors might interact with environmental factors to affect risk of EA and BE. We aimed to identify single nucleotide polymorphisms (SNPs) that may modify the associations of body mass index (BMI), smoking, and gastroesophageal reflux disease (GERD), with risks of EA and BE...
March 15, 2018: Clinical Gastroenterology and Hepatology
Dale A Halbritter, Nicholas M Teets, Caroline M Williams, Jaret C Daniels
Predicting how rapid climate change will affect terrestrial biota depends on a thorough understanding of an organism's biology and evolutionary history. Organisms at their range boundaries are particularly sensitive to climate change. As predominantly terrestrial poikilotherms, insects are often geographically limited by extremes in ambient temperatures. We compared the cold hardiness strategies of two geographically widespread butterflies, the pine white, Neophasia menapia, and the Mexican pine white, N. terlooii (Lepidoptera: Pieridae), at the near-contact zone of their range boundaries...
March 15, 2018: Journal of Insect Physiology
Zhangbiao Long, Yali Du, Hongmin Li, Bing Han
Patients with paroxysmal nocturnal hemoglobinuria (PNH) who have minor allele of the complement receptor 1 (CR1) gene, displayed more sub-optimal responder to eculizumab compared with major allele. To investigate polymorphism of the CR1 gene in Chinese patients with PNH and its correlation with clinical features and the potential impact on eculizumab efficiency, we genotyped CR1 rs2274567, rs3811381 and the intron 27 Hind III restriction fragment length polymorphism in 95patients with PNH and 96 controls. The results indicated that the genotypes of CR1 rs2274567, rs3811381 and the intron 27 Hind III in PNH patients and controls both consist with Hardy-Weinberg equilibrium...
March 15, 2018: Gene
Jane Hardy, Hayley Kuter, Malcolm Campbell, Dexter Canoy
OBJECTIVE: To determine the reliability of anthropometric and body composition measurements in children with special needs. DESIGN: Observational study. SETTING: Specialist support schools (primary and secondary) in Manchester, UK. PARTICIPANTS: 53 children with moderate-to-severe learning disability; 30 non-standers (14 boys) and 23 standers (15 boys). Mean ages were 11 years (range 3-20) for non-standers and 12.4 years (range 8-19) for standers...
March 17, 2018: Archives of Disease in Childhood
Xiaoni Zhan, Atif Adnan, Yuzhang Zhou, Amjad Khan, Kadirya Kasim, Dennis McNevin
The Xinjiang Uyghur Autonomous Region of China (XUARC) harbors 47 ethnic groups including the Manchu (MCH: 0.11%), Mongols (MGL: 0.81%), Kyrgyz (KGZ: 0.86%) and Uzbek (UZK: 0.066%). To establish DNA databases for these populations, allele frequency distributions for 15 autosomal short tandem repeat (STR) loci were determined using the AmpFlSTR Identifiler PCR amplification kit. There was no evidence of departures from Hardy-Weinberg equilibrium (HWE) in any of the four populations and minimal departure from linkage equilibrium (LE) for a very small number of pairwise combinations of loci...
March 16, 2018: Scientific Reports
Dafna Greitzer-Antes, Li Xie, Tairan Qin, Huanli Xie, Dan Zhu, Subhankar Dolai, Tao Liang, Fei Kang, Alexandre B Hardy, Yan He, Youhou Kang, Herbert Y Gaisano
The voltage-dependent K+ (Kv) channel Kv2.1 is a major delayed rectifier in many secretory cells, including pancreatic β-cells. In addition, Kv2.1 has a direct role in exocytosis at an undefined step, involving SNARE proteins and independent of its ion-conducting pore function. Here, we elucidated the precise step in exocytosis. We previously reported that syntaxin 3 (Syn-3) is the key syntaxin that mediates exocytosis of newcomer secretory granules that spend minimal residence time on the plasma membrane before fusion...
March 16, 2018: Journal of Biological Chemistry
Balaraman Kalyanaraman, Gang Cheng, Micael Hardy, Olivier Ouari, Marcos Lopez, Joy Joseph, Jacek Zielonka, Michael B Dwinell
No abstract text is available yet for this article.
March 13, 2018: Redox Biology
Xianhua Wang, Aiguo Ma, Xiuxia Han, Aishan Litifu, Feng Xue
Seven single-nucleotide polymorphism (SNP) sites located in ASAP1 gene have been found associated with tuberculosis (TB) susceptibility by genome-wide association studies in Russia. The case-control study was carried out to test whether these seven SNPs were associated with susceptibility to TB in a Chinese Xinjiang Muslim population. The seven SNPs were genotyped in a case-control design that included 780 Xinjiang Muslim subjects (400 TB patients and 380 controls). Multiplex PCR and direct sequencing were used to detect ASAP1 gene polymorphisms...
April 2018: Experimental and Therapeutic Medicine
Celeste Sassi, Michael A Nalls, Perry G Ridge, Jesse R Gibbs, Michelle K Lupton, Claire Troakes, Katie Lunnon, Safa Al-Sarraj, Kristelle S Brown, Christopher Medway, Jenny Lord, James Turton, Jose Bras, Sonja Blumenau, Mareike Thielke, Christa Josties, Dorette Freyer, Annette Dietrich, Monia Hammer, Michael Baier, Ulrich Dirnagl, Kevin Morgan, John F Powell, John S Kauwe, Carlos Cruchaga, Alison M Goate, Andrew B Singleton, Rita Guerreiro, Angela Hodges, John Hardy
Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive neurodegenerative disorders affecting the white matter of the central nervous system. Among these, cerebral autosomal dominant and recessive arteriopathy with subcortical infarcts and leukoencephalopathy, cerebroretinal vasculopathy, metachromatic leukodystrophy, hereditary diffuse leukoencephalopathy with spheroids, and vanishing white matter disease present with rapidly progressive dementia as dominant feature and are caused by mutations in NOTCH3, HTRA1, TREX1, ARSA, CSF1R, EIF2B1, EIF2B2, EIF2B3, EIF2B4, and EIF2B5, respectively...
February 2, 2018: Neurobiology of Aging
Edward J Steele, Shirwan Al-Mufti, Kenneth A Augustyn, Rohana Chandrajith, John P Coghlan, S G Coulson, Sudipto Ghosh, Mark Gillman, Reginald M Gorczynski, Brig Klyce, Godfrey Louis, Kithsiri Mahanama, Keith R Oliver, Julio Padron, Jiangwen Qu, John A Schuster, W E Smith, Duane P Snyder, Julian A Steele, Brent J Stewart, Robert Temple, Gensuke Tokoro, Christopher A Tout, Alexander Unzicker, Milton Wainwright, Jamie Wallis, Daryl H Wallis, Max K Wallis, John Wetherall, D T Wickramasinghe, J T Wickramasinghe, N Chandra Wickramasinghe, Yongsheng Liu
We review the salient evidence consistent with or predicted by the Hoyle-Wickramasinghe (H- W) thesis of Cometary (Cosmic) Biology. Much of this physical and biological evidence is multifactorial. One particular focus are the recent studies which date the emergence of the complex retroviruses of vertebrate lines at or just before the Cambrian Explosion of ∼500 Ma. Such viruses are known to be plausibly associated with major evolutionary genomic processes. We believe this coincidence is not fortuitous but is consistent with a key prediction of H-W theory whereby major extinction-diversification evolutionary boundaries coincide with virus-bearing cometary-bolide bombardment events...
March 12, 2018: Progress in Biophysics and Molecular Biology
Marianne Lorcet, Alain Lortholary, Jean Emmanuel Kurtz, Dominique Berton-Rigaud, Michel Fabbro, Thibault De La Motte Rouge, Marie Christine Kaminsky-Forrett, Anne Floquet, Gilles Freyer, Pierre Combe, Nadine Dohollou, Elsa Kalbacher, Raymond Despax, Remy Largillier, Anne Claire Hardy Bessard, Nicolas Gane, Jalid Sehouli, Guelten Oskay-Oezcelik, Idlir Licaj, Isabelle Ray-Coquard, Florence Joly Lobbedez
BACKGROUND: Expression IV survey evaluated the patients' expectations to a maintenance therapy. METHODS: From January 2015 to March 2016, 401 French patients, in first line or recurrent disease, answered a 24-items anonymous questionnaire. The results were specifically analyzed according to the demographic characteristics and treatment lines. RESULTS: Among the patients, 62% had already been informed about maintenance therapy. Thirty-seven percent of patients received a maintenance treatment: 111 patients during first line and 39 patients in relapse...
March 12, 2018: Bulletin du Cancer
Ibrahim Batal, Sumit Mohan, Sacha A De Serres, Elena-Rodica Vasilescu, Demetra Tsapepas, Russel J Crew, Shefali S Patel, Geo Serban, Kasi McCune, Syed A Husain, Jae-Hyung Chang, Jan M Herter, Govind Bhagat, Glen S Markowitz, Vivette D D'Agati, Mark A Hardy, Lloyd Ratner, Anil Chandraker
Ischemia-reperfusion injury increases allograft immunogenicity and enhances myeloid dendritic cell maturation and trafficking to recipient's secondary lymphoid tissue. Here, we used postreperfusion biopsies from patients who received kidney allografts from deceased donors between 2006 and 2009 to assess the impact of ischemia-reperfusion damage and myeloid dendritic cell density on subsequent allograft rejection episodes. Histologic changes of severe ischemia-reperfusion damage in postreperfusion biopsies were found to be associated with subsequent rejection episodes and suboptimal allograft survival...
March 13, 2018: Kidney International
Christian A Schaer, Catherine Owczarek, Jeremy W Deuel, Stefan Schauer, Jin Hyen Baek, Ayla Yalamanoglu, Matthew P Hardy, Pierre D Scotney, Peter M Schmidt, Matthias Pelzing, Peter Soupourmas, Paul W Buehler, Dominik J Schaer
BACKGROUND: Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrated efficacy of Hp in hemolysis associated with transfusion and sickle cell anemia. However, phenotype-specific Hp products might be desirable to exploit phenotype specific activities of Hp 1-1 versus Hp 2-2, offering opportunities for recombinant therapeutics. Prohaptoglobin (proHp) is the primary translation product of the Hp mRNA...
March 15, 2018: BMC Biotechnology
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