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JOURNAL ARTICLE
Hardi Vadher, Kristi Baerg MacDonald, Sarah Ross, Julie Aitken Schermer
The Connectorship Scale was designed to assess how leaders connect with their followers and is described to measure eight dimensions: social interactivity, dependability, positive communication, presenting oneself, storytelling ability, belief in networking, tangible introduction, and belief in the importance of online networking. This study explores the scale properties and confirmatory factor analyses (CFA) of the Connectorship Scale and examines how the scale scores correlate with self-efficacy and extraversion based on responses from 454 (52% women) adult business students...
April 23, 2024: Psychological Reports
#2
JOURNAL ARTICLE
Pranay Sinha, Komala Ezhumalai, Xinyi Du, Chinnaiyan Ponnuraja, Madolyn Rose Dauphinais, Nikhil Gupte, Sonali Sarkar, Amita Gupta, Sanjay Gaikwad, Balamugesh Thangakunam, Mandar Paradkar, Devasahayam J Christopher, Vidya Mave, Vijay Viswanathan, Jerrold J Ellner, Hardy Kornfeld, C R Horsburgh, Chandrasekaran Padmapriyadarsini, Akshay Gupte
Undernutrition is the leading risk factor for tuberculosis (TB) globally and in India. This multicenter prospective cohort analysis from India suggests that undernutrition is associated with increased risk of TB disease but not TB infection among household contacts of persons with TB.
April 23, 2024: Clinical Infectious Diseases
#3
JOURNAL ARTICLE
Ghazal Ahmadzadeh Shad, Ali Ghasemi, Maryam Zadsar, Mojgan Shaeigan, Shahram Samiee, Ahad Zare
BACKGROUND: Recurrent abortion refers to a condition of two or more consecutive pregnancies without known etiology affected by miscarriage before the completion of the 20th week of gestational age. However, several hypotheses have been proposed, but not much data are available concerning the relationship between human platelet antigens (HPAs) polymorphisms and recurrent abortion. This study was conducted to evaluate the genetic differences between HPA-1, -2, -3, -5, and - 15 in Iranian couples with a history of recurrent abortion...
2024: Frontiers in Medicine
#4
JOURNAL ARTICLE
Diego Angeles-Valdez, Jalil Rasgado-Toledo, Viviana Villicaña, Alan Davalos-Guzman, Cristina Almanza, Alfonso Fajardo-Valdez, Ruth Alcala-Lozano, Eduardo A Garza-Villarreal
Cocaine use disorder (CUD) is a global health problem with severe consequences, leading to behavioral, cognitive, and neurobiological disturbances. While consensus on treatments is still ongoing, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising approach for medication-resistant disorders, including substance use disorders. In this context, here we present the SUDMEX-TMS, a Mexican dataset from an rTMS clinical trial involving CUD patients. This longitudinal dataset comprises 54 CUD patients (including 8 females) with data collected at five time points: baseline (T0), two weeks (T1), three months (T2), six months (T3) follow-up, and twelve months (T4) follow-up...
April 22, 2024: Scientific Data
#5
JOURNAL ARTICLE
David S Kirwin, Harrison E Diaz, Travis C Frantz, Cory F Janney, Curtis L Hardy, W Hugh Lyford
Wound healing is crucial for survival, prevention of infection, and restoration of tissue function. The immune system drives this process with 3 main phases: inflammation, proliferation, and remodeling. Keloids and hypertrophic scars reveal disruptions in these phases, underscoring the balance needed for healing. Limb amputation, a life-changing event, demands careful consideration for healing and function. Factors such as amputation level, surgical technique, and prosthetic fitting shape outcomes, while complications such as heterotopic ossification challenge recovery...
March 2024: Cutis; Cutaneous Medicine for the Practitioner
#6
JOURNAL ARTICLE
Dan Jk Yombo, Sudhir Ghandikota, Chanukya P Vemulapalli, Priyanka Singh, Anil G Jegga, William D Hardie, Sathish K Madala
Idiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to excessive production and deposition of extracellular matrix (ECM) within the lung parenchyma. Despite the pivotal role of ECM overexpression in IPF, potential negative regulators of ECM production in fibroblasts have yet to be identified. Semaphorin class 3B (SEMA3B), a secreted protein highly expressed in lung tissues, has established roles in axonal guidance and tumor suppression. However, the role of SEMA3B in ECM production by fibroblasts in the pathogenesis of IPF remains unexplored...
April 22, 2024: American Journal of Physiology. Cell Physiology
#7
JOURNAL ARTICLE
Ellen Carlin, Claire E Standley, Emily Hardy, Daniel Donachie, Tianna Brand, Lydia Greve, Sonia Fevre, Clare Wenham
There has been increasing recognition of gender-based inequity as a barrier to successful policy implementation. This consensus, coupled with an increasing frequency of emergencies in human and animal populations, including infectious disease events, has prompted policy makers to re-evaluate gender-sensitivity in emergency management planning. Seeking to identify key publications relating to gendered impacts and considerations across diverse stakeholders in different types of animal health emergencies, we conducted a non-exhaustive, targeted scoping review...
2024: Frontiers in Veterinary Science
#8
JOURNAL ARTICLE
Jonathan M Kormann, Ernst van der Maaten, Mirko Liesebach, Katharina J Liepe, Marieke van der Maaten-Theunissen
Information about the resistance and adaptive potential of tree species and provenances is needed to select suitable planting material in times of rapidly changing climate conditions. In this study, we evaluate growth responses to climatic fluctuations and extreme events for 12 provenances of northern red oak ( Quercus rubra L.) that were tested across three trial sites with distinct environmental conditions in Germany. Six provenances each were sourced from the natural distribution in North America and from introduced stands in Germany...
2024: Frontiers in Plant Science
#9
Simon Dellicour, Paul Bastide, Pauline Rocu, Denis Fargette, Olivier J Hardy, Marc A Suchard, Stéphane Guindon, Philippe Lemey
Genomic data collected from viral outbreaks can be exploited to reconstruct the dispersal history of viral lineages in a two-dimensional space using continuous phylogeographic inference. These spatially explicit reconstructions can subsequently be used to estimate dispersal metrics allowing to unveil the dispersal dynamics and evaluate the capacity to spread among hosts. Heterogeneous sampling intensity of genomic sequences can however impact the accuracy of dispersal insights gained through phylogeographic inference...
April 11, 2024: bioRxiv
#10
EDITORIAL
John Torous, Katharine A Smith, Amy Hardy, Anastasia Vinnikova, Charlotte Blease, Lea Milligan, Diego Hidalgo-Mazzei, Sinead Lambe, Lisa Marzano, Peter J Uhlhaas, Edoardo G Ostinelli, Gerard Anmella, Caroline Zangani, Rosario Aronica, Bridget Dwyer, Andrea Cipriani
No abstract text is available yet for this article.
April 18, 2024: Schizophrenia Research
#11
JOURNAL ARTICLE
Jeffrey Dalli, Jonathan P Epperlein, Niall P Hardy, Mohammad Faraz Khan, Pol Mac Aonghusa, Ronan A Cahill
INTRODUCTION: Intraoperative indocyanine green fluorescence angiography (ICGFA) aims to reduce colorectal anastomotic complications. However, signal interpretation is inconsistent and confounded by patient physiology and system behaviours. Here, we demonstrate a proof of concept of a novel clinical and computational method for patient calibrated quantitative ICGFA (QICGFA) bowel transection recommendation. METHODS: Patients undergoing elective colorectal resection had colonic ICGFA both immediately after operative commencement prior to any dissection and again, as usual, just before anastomotic construction...
April 18, 2024: Surgical Endoscopy
#12
JOURNAL ARTICLE
M C Fabbri, F Tiezzi, A Crovetti, C Maltecca, R Bozzi
The analysis of livestock heterozygosity is less common compared to the study of homozygous patterns. Heterozygous-Rich Regions (HRRs) may harbor significant loci for functional traits such as immune response, survival rate, and fertility. For this reason, this study was conducted to investigate and characterize the heterozygosity patterns of four beef cattle breeds, which included two cosmopolitan breeds (Limousine and Charolaise) and two local breeds (Sarda and Sardo Bruna). Our analysis identified regions with a high degree of heterozygosity using a consecutive runs approach, the Tajima D test, nucleotide diversity estimation, and Hardy Weinberg equilibrium test...
March 25, 2024: Animal
#13
JOURNAL ARTICLE
Ariel C Toloza, Marina S Ascunce, David L Reed
The cosmopolitan ectoparasite human head louse, Pediculus humanus capitis (De Geer)(Phthiraptera:Pediculidae), affects mostly school-aged children, with infestations reported every year mainly due to louse resistance to pyrethroids. One of the main resistance mechanisms of pyrethroids is the target site insensitivity (kdr), which is caused by single-nucleotide point mutations (SNPs) located in the voltage-sensitive sodium channel gene. In this study, we analyzed individual head lice toxicologically via the description of their susceptibility profile to permethrin and genetically through the genotypification of their kdr alleles as well as nuclear microsatellite loci...
April 18, 2024: Journal of Medical Entomology
#14
JOURNAL ARTICLE
Glenn Ramsey, Christina M Barriteau
BACKGROUND: For patients with weak or discrepant RhD RBC phenotypes, RHD genotyping is employed to determine need for RhD-negative management. However, many RHD variants are type D-negative or D-positive. Serological recognition rates (RRs) of weak and partial RHD variants are poorly characterized. STUDY DESIGN AND METHODS: Four US studies employing RHD genotyping for weak or discrepant RhD phenotypes provided data for race/ethnicity-specific serological recognition...
April 18, 2024: Transfusion
#15
JOURNAL ARTICLE
Wawaimuli Arozal, Muhamad Sadam Safutra, Agian Jeffilano Barinda, Harri Hardi, Nounik Cheri Dwita, Hee J Lee
Several studies have demonstrated that Moringa oleifera (MO) has different pharmacological properties, including neuroprotective effects. However, the role of MO in preventing brain impairment in high-fat, high-fructose diet (HFFD) remains unknown. This study aimed to investigate the neuroprotective effects of MO leaves aqueous extract (MOE) and moringa seed oil (MOO) against brain impairment in mice with HFFD. Twenty-eight male mice were randomly divided into four groups: normal diet, HFFD, HFFD + MOE 500 mg/kgBW, and HFFD + MOO 2 mL/kgBW...
2024: TheScientificWorldJournal
#16
JOURNAL ARTICLE
Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nicole Tamvaka, Ronald L Walton, Matthew C Baker, Hannah L Macpherson, Raquel Real, Alexandra I Soto-Beasley, Kin Mok, Tamas Revesz, Elizabeth A Christopher, Michael DeTure, William W Seeley, Edward B Lee, Matthew P Frosch, Laura Molina-Porcel, Tamar Gefen, Javier Redding-Ochoa, Bernardino Ghetti, Andrew C Robinson, Christopher Kobylecki, James B Rowe, Thomas G Beach, Andrew F Teich, Julia L Keith, Istvan Bodi, Glenda M Halliday, Marla Gearing, Thomas Arzberger, Christopher M Morris, Charles L White, Naguib Mechawar, Susana Boluda, Ian R MacKenzie, Catriona McLean, Matthew D Cykowski, Shih-Hsiu J Wang, Caroline Graff, Rashed M Nagra, Gabor G Kovacs, Giorgio Giaccone, Manuela Neumann, Lee-Cyn Ang, Agostinho Carvalho, Huw R Morris, Rosa Rademakers, John A Hardy, Dennis W Dickson, Jonathan D Rohrer, Owen A Ross
BACKGROUND: Pick's disease is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary tauopathy. Pick's disease is pathologically defined by the presence in the frontal and temporal lobes of Pick bodies, composed of hyperphosphorylated, three-repeat tau protein, encoded by the MAPT gene. MAPT has two distinct haplotypes, H1 and H2; the MAPT H1 haplotype is the major genetic risk factor for four-repeat tauopathies (eg, progressive supranuclear palsy and corticobasal degeneration), and the MAPT H2 haplotype is protective for these disorders...
May 2024: Lancet Neurology
#17
JOURNAL ARTICLE
Tsung-I Hsu, Yi-Ping Chen, Rong-Lin Zhang, Zih-An Chen, Cheng-Hsun Wu, Wen-Chang Chang, Chung-Yuan Mou, Hardy Wai-Hong Chan, Si-Han Wu
While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (DTX), providing a novel approach for treating TMZ-resistant GBM...
April 17, 2024: ACS Applied Materials & Interfaces
#18
JOURNAL ARTICLE
Alexander K Lancaster, Richard M Single, Steven J Mack, Vanessa Sochat, Michael P Mariani, Gordon D Webster
Python for Population Genomics (PyPop) is a software package that processes genotype and allele data and performs large-scale population genetic analyses on highly polymorphic multi-locus genotype data. In particular, PyPop tests data conformity to Hardy-Weinberg equilibrium expectations, performs Ewens-Watterson tests for selection, estimates haplotype frequencies, measures linkage disequilibrium, and tests significance. Standardized means of performing these tests is key for contemporary studies of evolutionary biology and population genetics, and these tests are central to genetic studies of disease association as well...
2024: Frontiers in Immunology
#19
JOURNAL ARTICLE
Adrienn Tóth, Jordan H Chamberlin, Salvador Mendez, Akos Varga-Szemes, Andrew D Hardie
OBJECTIVES: To assess the range of quantitative iodine values in renal cysts (RC) (with a few renal neoplasms [RNs] as a comparison) to develop an expected range of values for RC that can be used in future studies for their differentiation. MATERIAL AND METHODS: Consecutive patients ( n = 140) with renal lesions who had undergone abdominal examination on a clinical photon-counting computed tomography (PCCT) were retrospectively included. Automated iodine quantification maps were reconstructed, and region of interest (ROI) measurements of iodine concentration (IC) (mg/cm3 ) were performed on whole renal lesions...
2024: Journal of Clinical Imaging Science
#20
JOURNAL ARTICLE
Erica Soster, Tamara Mossfield, Melody Menezes, Gloudi Agenbag, Marie-Line Dubois, Jean Gekas, Tristan Hardy, Kelly Loggenberg
Trisomy 20 has been shown to be one of the most frequent rare autosomal trisomies in patients that undergo genome-wide noninvasive prenatal testing. Here, we describe the clinical outcomes of cases that screened positive for trisomy 20 following prenatal genome-wide cell-free (cf.) DNA screening. These cases are part of a larger cohort of previously published cases. Members of the Global Expanded NIPT Consortium were invited to submit details on their cases with a single rare autosomal aneuploidy following genome-wide cfDNA screening for retrospective analysis...
April 16, 2024: Molecular Cytogenetics
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