Muhammad Alamzeb, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Shujaat Ahmad, Ehsan Ullah Mughal, Saeed Ahmad, Ihsan Ullah, Shahzeb Khan, Abid Ullah, Mehreen Ghias, Riaz Ullah, Essam A Ali
Diabetes, also known as diabetes mellitus (DM), is a metabolic disorder characterized by an abnormal rise in blood sugar (glucose) levels brought on by a complete or partial lack of insulin secretion along with corresponding changes in the metabolism of lipids, proteins, and carbohydrates. It has been reported that medicinal plants play a pivotal role in the treatment of various ailments such as diabetes mellitus, dyslipidemia, and hypertension. The current study involved exploring the acute toxicity and in vivo antidiabetic activity of berberine ( WA1 ), palmatine ( WA2 ), and 8-trichloromethyl dihydroberberine ( WA3 ) previously isolated from Berberis glaucocarpa Stapf using a streptozotocin (STZ)-induced diabetic rat model...
February 27, 2024: ACS Omega