keyword
MENU ▼
Read by QxMD icon Read
search

multigeneration

keyword
https://www.readbyqxmd.com/read/29656515/comparative-cyp-omic-analysis-between-the-ddt-susceptible-and-resistant-drosophila-melanogaster-strains-91-c-and-91-r
#1
Keon Mook Seong, Brad S Coates, May R Berenbaum, John M Clark, Barry R Pittendrigh
BACKGROUND: Cytochrome P450 monooxygenases (P450s) are involved in the biosynthesis of endogenous intracellular compounds and the metabolism of xenobiotics, including chemical insecticides. We investigated the structural and expression level variance across all P450 genes with respect to the evolution of insecticide resistance under multigenerational DDT selection. RESULTS: RNA-seq and reverse transcriptase quantitative PCR indicated that the transcript levels of seven P450 genes were significantly up-regulated and three P450 genes were down-regulated in the DDT-resistant strain 91-R, as compared to the control strain 91-C...
April 15, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29652896/a-cohort-study-of-the-effects-of-older-adult-care-dependence-upon-household-economic-functioning-in-peru-mexico-and-china
#2
Maëlenn M Guerchet, Mariella Guerra, Yueqin Huang, Peter Lloyd-Sherlock, Ana Luisa Sosa, Richard Uwakwe, Isaac Acosta, Peter Ezeah, Sara Gallardo, Zhaorui Liu, Rosie Mayston, Veronica Montes de Oca, Hong Wang, Martin J Prince
BACKGROUND: While links between disability and poverty are well established, there have been few longitudinal studies to clarify direction of causality, particularly among older adults in low and middle income countries. We aimed to study the effect of care dependence among older adult residents on the economic functioning of their households, in catchment area survey sites in Peru, Mexico and China. METHODS: Households were classified from the evolution of the needs for care of older residents, over two previous community surveys, as 'incident care', 'chronic care' or 'no care', and followed up three years later to ascertain economic outcomes (household income, consumption, economic strain, satisfaction with economic circumstances, healthcare expenditure and residents giving up work or education to care)...
2018: PloS One
https://www.readbyqxmd.com/read/29627549/prolonged-exposure-of-di-2-ethylhexyl-phthalate-induces-multigenerational-toxic-effects-in-caenorhabditis-elegans
#3
Shang-Wei Li, Chun Ming How, Vivian Hsiu-Chuan Liao
The plasticizer di(2-ethylhexyl) phthalate (DEHP) is an emerging organic contaminant that has represented a risk for organisms present in the environment. However, there is still limited information regarding DEHP-induced multigenerational toxicity and the underlying mechanisms. In this study we investigated the multigenerational toxic effects including locomotive behaviors and reproduction upon prolonged DEHP exposure (from larval L1 to adult) and the underlying mechanisms in the nematode Caenorhabditis elegans...
April 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29590363/the-intergenerational-consequences-of-war-anxiety-depression-suicidality-and-mental-health-among-the-children-of-war-veterans
#4
Walter Forrest, Ben Edwards, Galina Daraganova
Background: The long-term effects of military deployment on the mental health of war veterans have been investigated extensively, but few studies have examined the long-term impact of parental deployment on children's mental health. Methods: Using a retrospective, multigenerational survey and propensity score analysis to adjust for selection effects and endogeneity bias, we investigated the impact of parental deployment on the mental health of the adult children of Australian veterans of the Vietnam War...
March 24, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29580187/grandparenting-and-self-rated-health-among-older-korean-women
#5
Seung-Won Choi, Zhenmei Zhang
An increasing number of older Korean women have played an important role in taking care of their grandchildren to help their adult children. This study investigates the effects of grandparenting on older women' health in South Korea. Using the Korean Longitudinal Study of Aging ( N = 3,092), we estimated ordinal logistic regression models with lagged dependent variable to examine whether and how grandparenting type and transition and grandparenting intensity are associated with older women's self-rated health...
January 1, 2018: Research on Aging
https://www.readbyqxmd.com/read/29572196/familial-hypertrophic-cardiomyopathy-identification-of-cause-and-risk-stratification-through-exome-sequencing
#6
Amitabh Biswas, Soumi Das, Mitali Kapoor, Karuthedath Vellarikkal Shamsudheen, Rijith Jayarajan, Ankit Verma, Sandeep Seth, Balram Bhargava, Vinod Scaria, Sridhar Sivasubbu, V R Rao
BACKGROUND: Hypertrophic cardiomyopathy with variable clinical presentations and heterogeneity is the common cause of sudden cardiac death. Genetic diagnosis is challenging in these complex diseases but exome sequencing as a genetic diagnostic tool provides explainable results. METHODS: In a familial Hypertrophic cardiomyopathy with multigenerational inheritance with apparent phenotype, had a history of sudden death and severe arrhythmia followed by implantation of Implantable cardioverter defibrillator...
March 20, 2018: Gene
https://www.readbyqxmd.com/read/29567492/paternal-cocaine-disrupts-offspring-circadian-clock-function-in-a-sex-dependent-manner-in-mice
#7
Alexandra M Yaw, Robert W Woodruff, Rebecca A Prosser, J David Glass
The present study is the first to explore the multigenerational effects of mammalian paternal cocaine intake on offspring (F1) circadian clock regulation. Parental cocaine use poses significant health risks to the offspring, through both maternal and paternal drug influences. With respect to the latter, recent evidence suggests that a paternal mode of cocaine inheritance involves epigenetic germ line actions that can ultimately disrupt offspring behavior. Based on our previous report in mice that free-running circadian period (tau) is chronically lengthened following withdrawal from long term cocaine treatment, the present study was undertaken to explore potential epigenetic effects of paternal exposure to cocaine over the ∼40 day murine spermatogenic cycle on F1 circadian regulatory functions...
March 19, 2018: Neuroscience
https://www.readbyqxmd.com/read/29565584/multigenerational-disruption-of-the-thyroid-endocrine-system-in-marine-medaka-after-a-life-cycle-exposure-to-perfluorobutanesulfonate
#8
Lianguo Chen, Chenyan Hu, Mirabelle M P Tsui, Teng Wan, Drew R Peterson, Qipeng Shi, Paul K S Lam, Doris W T Au, James C W Lam, Bingsheng Zhou
Accumulation of perfluorobutanesulfonate (PFBS) is frequently detected in biota, raising concerns about its ecological safety. However, hazardous effects of PFBS remain largely unexplored, especially for endocrine disrupting potency. In the present study, the multigenerational endocrine disrupting potential of PFBS was investigated by exposing F0 marine medaka eggs to PFBS at different concentrations (0, 1.0, 2.9, and 9.5 μg/L) until sexual maturity. The F1 and F2 generations were reared without continued exposure...
April 3, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29559526/multigenerational-memory-and-adaptive-adhesion-in-early-bacterial-biofilm-communities
#9
Calvin K Lee, Jaime de Anda, Amy E Baker, Rachel R Bennett, Yun Luo, Ernest Y Lee, Joshua A Keefe, Joshua S Helali, Jie Ma, Kun Zhao, Ramin Golestanian, George A O'Toole, Gerard C L Wong
Using multigenerational, single-cell tracking we explore the earliest events of biofilm formation by Pseudomonas aeruginosa During initial stages of surface engagement (≤20 h), the surface cell population of this microbe comprises overwhelmingly cells that attach poorly (∼95% stay <30 s, well below the ∼1-h division time) with little increase in surface population. If we harvest cells previously exposed to a surface and direct them to a virgin surface, we find that these surface-exposed cells and their descendants attach strongly and then rapidly increase the surface cell population...
March 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29557905/heritability-and-genetic-correlations-of-heart-rate-variability-at-rest-and-during-stress-in-the-oman-family-study
#10
M Loretto Muñoz, Deepali Jaju, Saroja Voruganti, Sulayma Albarwani, Afshin Aslani, Riad Bayoumi, Said Al-Yahyaee, Anthony G Comuzzie, Philip J Millar, Peter Picton, John S Floras, Ilja Nolte, Mohammed O Hassan, Harold Snieder
INTRODUCTION: Individual differences in heart rate variability (HRV) can be partly attributed to genetic factors that may be more pronounced during stress. Using data from the Oman Family Study (OFS), we aimed to estimate and quantify the relative contribution of genes and environment to the variance of HRV at rest and during stress; calculate the overlap in genetic and environmental influences on HRV at rest and under stress using bivariate analyses of HRV parameters and heart rate (HR)...
March 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29542829/multigenerational-effects-of-nickel-on-daphnia-magna-depend-on-temperature-and-the-magnitude-of-the-effect-in-the-first-generation
#11
Cecília M S Pereira, Gert Everaert, Ronny Blust, Karel A C De Schamphelaere
Ecological risk assessment (ERA) is commonly based on single generation ecotoxicological tests that are usually performed at one standard temperature. We investigate the effects of nickel (Ni) on Daphnia magna reproduction at 15, 20 and 25°C along four generations. Multigenerational Ni effects on D. magna reproduction depended on the magnitude of the effect in the first generation (F0) and showed very different patterns at different temperatures. At low effect level concentrations (<EC10 of F0), chronic Ni toxicity at 15 and 20°C did not increase along four generations, and the increase of Ni toxicity at 25°C observed in F1 and F2 in some Ni treatments did not persist into F3, where complete recovery of reproduction was observed...
March 15, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29542440/should-race-be-used-as-a-variable-in-research-on-preterm-birth
#12
Kacey Y Eichelberger, Julianna G Alson, Kemi M Doll
Racial variations in preterm birth (PTB) outcomes are well described, but causal mechanisms linking race and PTB are not. In clinical research, race is typically treated as representing fixed biological traits. In reality, race is a social construct that approximates lived experiences of historical and ongoing systematic discrimination and, in the case of PTB, particular stressors of black womanhood and reproduction. These experiences are embodied as adverse multigenerational health outcomes. Race thus presents a dilemma for researchers...
March 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29535025/intergenerational-response-to-the-endocrine-disruptor-vinclozolin-is-influenced-by-maternal-genotype-and-crossing-scheme
#13
Edward W Pietryk, Kiristin Clement, Marwa Elnagheeb, Ryan Kuster, Kayla Kilpatrick, Michael I Love, Folami Y Ideraabdullah
In utero exposure to vinclozolin (VIN), an antiandrogenic fungicide, is linked to multigenerational phenotypic and epigenetic effects. Mechanisms remain unclear. We assessed the role of antiandrogenic activity and DNA sequence context by comparing effects of VIN vs. M2 (metabolite with greater antiandrogenic activity) and wild-type C57BL/6 (B6) mice vs. mice carrying mutations at the previously reported VIN-responsive H19/Igf2 locus. First generation offspring from VIN-treated 8nrCG mutant dams exhibited increased body weight and decreased sperm ICR methylation...
March 10, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29529428/multigenerational-exposure-of-folsomia-candida-to-silver-effect-of-different-contamination-scenarios-continuous-versus-pulsed-and-recovery
#14
L A Mendes, V L Maria, J J Scott-Fordsmand, M J B Amorim
Effects of pollutants are mostly assessed using standard testing procedures, which cover a fraction of the animals' life cycle. Although, in nature species are exposed during multiple generations of sub-lethal doses of persistent chemicals. In the present study, we focused on the multigenerational (MG) effects of silver in Folsomia candida during 6 generations using the EC50 for reproduction as exposure concentration. We tested 9 different exposure scenarios, going from continuous 6 generations Ag exposure over pulse exposure (i...
March 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29528675/cognition-and-community-functioning-in-schizophrenia-the-nature-of-the-relationship
#15
Susan S Kuo, Laura Almasy, Ruben C Gur, Konasale Prasad, David R Roalf, Raquel E Gur, Vishwajit L Nimgaonkar, Michael F Pogue-Geile
Although cognition is one of the most important predictors of community functioning in schizophrenia, little is known about the causes of this correlation. To our knowledge, this study is the first to examine the extent to which this correlation is genetically mediated and whether the genetic correlation is specific to schizophrenia. Six hundred thirty-six participants from 43 multigenerational families with at least two relatives with schizophrenia and 135 unrelated controls underwent diagnostic interview and cognition and functioning assessment...
February 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29514264/multigenerational-effects-of-a-reduced-balanced-protein-diet-during-the-rearing-and-laying-period-of-broiler-breeders-2-zootechnical-performance-of-the-f1-broiler-offspring
#16
J Lesuisse, S Schallier, C Li, A Bautil, B Li, J Leblois, J Buyse, N Everaert
Several studies in mammals focused on the maternal programming of the metabolism by epigenetic mechanisms, while currently, the consequences of a maternal dietary treatment on the offspring performance of farm animals are of particular interest for commercial purpose. In the present study, we investigated if the zootechnical performance of the progeny was altered by a maternal dietary treatment, being a lower dietary crude protein (CP) of the grandparent and/or parent generation. The multigenerational effects of a reduced maternal CP content were investigated by reducing the dietary CP level by 25% in rearing and laying diets of pure line A breeders...
March 5, 2018: Poultry Science
https://www.readbyqxmd.com/read/29509917/multigenerational-effects-of-a-reduced-balanced-protein-diet-during-the-rearing-and-laying-period-of-broiler-breeders-1-performance-of-the-f1-breeder-generation
#17
J Lesuisse, C Li, S Schallier, W L S Clímaco, A Bautil, N Everaert, J Buyse
Studies on mammals and poultry showed that maternal dietary treatments can alter the offspring performance. However, in contrast to rodent studies, little is known about multigenerational dietary manipulations in broiler breeders. The presented research aimed to investigate the effects of a reduction of 25% in the dietary crude protein (CP) level in the F0 generation on the body composition and reproductive performance of F1 broiler breeders. In the F0 generation, breeders were fed either a control (C) or reduced balanced protein (RP) diet, 25% reduction in crude protein and amino acids...
March 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29506442/the-impact-of-an-aging-population-in-the-workplace
#18
Mercedia Stevenson White, Candace Burns, Helen Acree Conlon
According to the Centers for Disease Control and Prevention, the number of people 65 years of age or older living in the United States is projected to double by 2030 to 72 million adults, representing 20% of the total U.S. POPULATION: Evidence suggests that older Americans are working longer and spending more time on the job than their peers did in previous years. The increased number of older adults working longer is observed not only in the Unites States but also worldwide. There are numerous ramifications associated with the changing demographics and the expanding prevalence of an aging population in the workforce...
March 1, 2018: Workplace Health & Safety
https://www.readbyqxmd.com/read/29500604/asymmetries-heterosis-and-phenotypic-profiles-of-red-junglefowl-white-plymouth-rocks-and-f-1-and-f-2-reciprocal-crosses
#19
D A T Sutherland, C F Honaker, B Dorshorst, L Andersson, P B Siegel
During the domestication of farm animals, humans have manipulated genetic variation for growth and reproduction through artificial selection. Here, data are presented for growth, reproductive, and behavior traits for the red junglefowl, a line of White Plymouth Rock chickens, and their F1 and F2 reciprocal crosses. Intra- and intergenerational comparisons for growth related traits reflected considerable additive genetic variation. In contrast, those traits associated with reproduction exhibited heterosis. The role of sexual selection was seen in the evolution of prominent secondary sexual ornaments that lend to female choice and male-male competition...
March 2, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29494901/attempted-suicide-in-sri-lanka-an-epidemiological-study-of-household-and-community-factors
#20
D W Knipe, D Gunnell, M Pearson, S Jayamanne, R Pieris, C Priyadarshana, M Weerasinghe, K Hawton, F Konradsen, M Eddleston, C Metcalfe
BACKGROUND: An individual's suicide risk is determined by personal characteristics, but is also influenced by their environment. Previous studies indicate a role of contextual effects on suicidal behaviour, but there is a dearth of quantitative evidence from Asia. METHODS: Individual and community level data were collected on 165,233 people from 47,919 households in 171 communities in rural Sri Lanka. Data were collected on individual (age, sex, past suicide attempts and individual socioeconomic position (SEP)) and household (household SEP, pesticide access, alcohol use and multigenerational households) level factors...
February 5, 2018: Journal of Affective Disorders
keyword
keyword
72845
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"