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https://www.readbyqxmd.com/read/28069474/heart-failure-in-late-pregnancy-and-postpartum-incidence-and-long-term-mortality-in-sweden-1997-2010
#1
Anders Barasa, Annika Rosengren, Tatiana Zverkova Sandström, Lars Ladfors, Maria Schaufelberger
AIMS: Heart failure (HF) in late pregnancy and postpartum (HFPP) of which peripartum cardiomyopathy (PPCM) comprises the larger part, is still a rare occurrence in Sweden. Population-based data are scarce. Our aim was to characterise HFPP and determine the incidence and mortality in a Swedish cohort. METHODS AND RESULTS: Through merging data from the National Inpatient, Cause of Death, and Medical Birth Registers, we identified ICD-10 codes for HF and cardiomyopathy, within 3 months before delivery up to 6 months postpartum...
January 6, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28067007/vaginal-progesterone-decreases-preterm-birth-and-neonatal-morbidity-and-mortality-in-women-with-a-twin-gestation-and-a-short-cervix-an-updated-meta-analysis-of-individual-patient-data
#2
REVIEW
Roberto Romero, Agustin Conde-Agudelo, Waleed El-Refaie, Line Rode, Maria L Brizot, Elcin Cetingoz, Vicente Serra, Eduardo da Fonseca, Mohamed S Abdelhafez, Ann Tabor, Alfredo Perales, Sonia S Hassan, Kypros H Nicolaides
OBJECTIVE: To assess the efficacy of vaginal progesterone for the prevention of preterm birth and neonatal morbidity and mortality in asymptomatic women with a twin gestation and a sonographic short cervix (cervical length ≤25 mm) in the midtrimester. METHODS: Updated systematic review and meta-analysis of individual patient data from randomized controlled trials comparing vaginal progesterone with placebo/no treatment in women with a twin gestation and a midtrimester sonographic cervical length ≤25 mm...
January 9, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28061767/the-effect-of-induction-method-in-twin-pregnancies-a-secondary-analysis-for-the-twin-birth-study
#3
Elad Mei-Dan, Elizabeth V Asztalos, Andrew R Willan, Jon F R Barrett
BACKGROUND: This secondary analysis for the Twin Birth Study, an international, multicenter trial, aimed to compare the cesarean section rates and safety between methods of induction of labor in twin pregnancies. METHODS: Women with twin pregnancies where the first twin was in a cephalic presentation and who presented for labor induction, were non-randomly assigned to receive prostaglandin or amniotomy and/or oxytocin. Main outcome measures were the rates of unplanned cesarean section and neonatal and maternal mortality or serious morbidity...
January 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28007049/comparable-risk-of-childhood-asthma-after-vaginal-delivery-and-emergency-caesarean-section
#4
Nis Brix, Lonny Stokholm, Fjola Jonsdottir, Kim Kristensen, Niels Jørgen Secher
INTRODUCTION: Caesarean section is thought to be a risk factor for childhood asthma, but this association may be caused by confounding from, for instance, familial factors. To address this problem, we used twin pairs to assess the risk of childhood asthma after emergency caesarean section. METHODS: The study was a register-based nation-wide matched cohort study using twin pairs to minimise residual confounding. Included were twin pairs in which the first twin was delivered vaginally and the second by emergency caesarean section during the study period from January 1997 through December 2012...
January 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/27981669/alcohol-use-disorder-and-divorce-evidence-for-a-genetic-correlation-in-a-population-based-swedish-sample
#5
Jessica E Salvatore, Sara Larsson Lönn, Jan Sundquist, Paul Lichtenstein, Kristina Sundquist, Kenneth S Kendler
AIMS: We tested the association between alcohol use disorder (AUD) and divorce; estimated the genetic and environmental influences on divorce; estimated how much genetic and environmental influences accounted for covariance between AUD and divorce; and estimated latent genetic and environmental correlations between AUD and divorce. We tested sex differences in these effects. DESIGN: We identified twin and sibling pairs with AUD and divorce information in Swedish national registers...
December 16, 2016: Addiction
https://www.readbyqxmd.com/read/27981394/heritability-of-working-in-a-creative-profession
#6
Mark Patrick Roeling, Gonneke Willemsen, Dorret I Boomsma
Creativity is the tendency to generate or recognize ideas, alternatives, or possibilities. Following a study on the genetic contribution to working in a creative profession, based on polygenic score analysis, we report the total heritability of this trait in a large sample of adult twins and their siblings registered with the Netherlands Twin Register. Data from 6755 twins and 1817 siblings were analyzed using genetic structural equation modeling. Working in a creative profession is relatively rare in our sample (2...
December 15, 2016: Behavior Genetics
https://www.readbyqxmd.com/read/27974054/heritability-of-tic-disorders-a-twin-family-study
#7
N R Zilhão, M C Olthof, D J A Smit, D C Cath, L Ligthart, C A Mathews, K Delucchi, D I Boomsma, C V Dolan
BACKGROUND: Genetic-epidemiological studies that estimate the contributions of genetic factors to variation in tic symptoms are scarce. We estimated the extent to which genetic and environmental influences contribute to tics, employing various phenotypic definitions ranging between mild and severe symptomatology, in a large population-based adult twin-family sample. METHOD: In an extended twin-family design, we analysed lifetime tic data reported by adult mono- and dizygotic twins (n = 8323) and their family members (n = 7164; parents and siblings) from 7311 families in the Netherlands Twin Register...
December 15, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27939851/age-specific-prevalence-of-hoarding-and-obsessive-compulsive-disorder-a-population-based-study
#8
Danielle C Cath, Krystal Nizar, Dorret Boomsma, Carol A Mathews
OBJECTIVE: Little is known about the age-specific prevalence of hoarding and obsessive compulsive symptoms (OCS), particularly in older age groups. The objectives of this study were to estimate the age-specific prevalence, severity, and relationships between hoarding and OCS in males and females using a large population-based sample. METHODS: We assessed the age-specific prevalence rates of hoarding disorder (HD) and OC disorder (OCD) in males and females (at various age ranges between 15 and 97 years) from the Netherlands Twins Register (N = 15,194)...
November 10, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27872260/familial-aggregation-and-heritability-of-schizophrenia-and-co-aggregation-of-psychiatric-illnesses-in-affected-families
#9
I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng, Weiya Zhang, Michael Doherty
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27852355/the-genetic-overlap-between-hair-and-eye-color
#10
Bochao D Lin, Gonneke Willemsen, Abdel Abdellaoui, Meike Bartels, Erik A Ehli, Gareth E Davies, Dorret I Boomsma, Jouke J Hottenga
We identified the genetic variants for eye color by Genome-Wide Association Study (GWAS) in a Dutch Caucasian family-based population sample and examined the genetic correlation between hair and eye color using data from unrelated participants from the Netherlands Twin Register. With the Genome-wide Complex Trait Analysis software package, we found strong genetic correlations between various combinations of hair and eye colors. The strongest positive correlations were found for blue eyes with blond hair (0...
December 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27852353/the-brazilian-twin-registry
#11
Paulo H Ferreira, Vinicius C Oliveira, Daniela R Junqueira, Lígia C Cisneros, Lucas C Ferreira, Kate Murphy, Juan R Ordoñana, John L Hopper, Luci F Teixeira-Salmela
The Brazilian Twin Registry (BTR) was established in 2013 and has impelled twin research in South America. The main aim of the initiative was to create a resource that would be accessible to the Brazilian scientific community as well as international researchers interested in the investigation of the contribution of genetic and environmental factors in the development of common diseases, phenotypes, and human behavior traits. The BTR is a joint effort between academic and governmental institutions from Brazil and Australia...
December 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27832812/a-longitudinal-cohort-study-of-acute-puerperal-metritis-cases-in-swedish-dairy-cows
#12
Anna Ordell, Helle Ericsson Unnerstad, Ann Nyman, Hans Gustafsson, Renée Båge
BACKGROUND: Acute puerperal metritis affects cows during the early postpartum period and causes fever, fetid vaginal discharge and general depression. The disease is severe and treatment with antimicrobials is often required. This study followed 79 Swedish dairy cows with acute puerperal metritis with registered treatment and outcome in terms of recovery. Bacteria isolated from the uterus and their susceptibility to penicillin were studied. Clinical cases were assigned by participating practitioners who examined the cows, performed uterine swab sampling, decided treatment and provided information about cow health and calving conditions...
November 10, 2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27825374/low-heritability-in-pharmacokinetics-of-talinolol-a-pharmacogenetic-twin-study-on-the-heritability-of-the-pharmacokinetics-of-talinolol-a-putative-probe-drug-of-mdr1-and-other-membrane-transporters
#13
Johannes Matthaei, Mladen V Tzvetkov, Valerie Gal, Cordula Sachse-Seeboth, Daniel Sehrt, Jakob B Hjelmborg, Ute Hofmann, Matthias Schwab, Reinhold Kerb, Jürgen Brockmöller
BACKGROUND: Efflux transporters like MDR1 and MRP2 may modulate the pharmacokinetics of about 50 % of all drugs. It is currently unknown how much of the variation in the activities of important drug membrane transporters like MDR1 or MRP2 is determined by genetic or by environmental factors. In this study we assessed the heritability of the pharmacokinetics of talinolol as a putative probe drug for MDR1 and possibly other membrane transporters. METHODS: Talinolol pharmacokinetics were investigated in a repeated dose study in 42 monozygotic and 13 same-sex dizygotic twin pairs...
November 8, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27806668/contemporary-management-of-neonatal-alloimmune-thrombocytopenia-good-outcomes-in-the-intravenous-immunoglobulin-era-results-from-the-australian-neonatal-alloimmune-thrombocytopenia-registry
#14
Gemma L Crighton, Ri Scarborough, Zoe K McQuilten, Louise E Phillips, Helen F Savoia, Bronwyn Williams, Rhonda Holdsworth, Amanda Henry, Erica M Wood, Stephen A Cole
OBJECTIVE: To describe the natural history, antenatal and postnatal therapy, and clinical outcomes of Australian patients with fetomaternal/neonatal alloimmune thrombocytopenia (NAIT) recorded in the Australian NAIT Registry. METHODS: Analysis of registry data of Australian mothers treated antenatally for NAIT and any fetus/newborn with thrombocytopenia (TCP) and maternal human platelet antigen (HPA) antibodies. RESULTS: 94 potential cases (91 pregnancies; three twin pregnancies) were registered between December 2004 and September 2015 with 76 confirmed or treated as NAIT...
November 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27799851/low-molecular-weight-heparin-can-benefit-women-with-recurrent-pregnancy-loss-and-sole-protein-s-deficiency-a-historical-control-cohort-study-from-taiwan
#15
Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin, Ming Chen
BACKGROUND: Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mutations, are relatively common in the Han Chinese population. In this study we aimed to investigate the therapeutic effect of low molecular weight heparin upon women with recurrent pregnancy loss and documented protein S deficiency. METHODS: During 2011-2016, 68 women with recurrent pregnancy loss (RPL) and protein S deficiency (both the free antigen and function of protein S were reduced) were initially enrolled...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27793415/a-sibling-based-design-to-quantify-genetic-and-shared-environmental-effects-of-venous-thromboembolism-in-sweden
#16
Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
INTRODUCTION: Few large studies have examined the heritability of venous thromboembolism (VTE). Moreover, twin studies have been suggested to overestimate heritability. The aim of the present study was to determine the heritability nationwide in the general Swedish population using full siblings and half-siblings. METHODS: VTE was defined using the Swedish patient register. Full sibling (FS) and half-sibling (HS) pairs born 1950-1990 were obtained from the Swedish Multi-generation Register...
January 2017: Thrombosis Research
https://www.readbyqxmd.com/read/27793372/validity-of-self-reported-endometriosis-and-endometriosis-related-questions-in-a-swedish-female-twin-cohort
#17
Rama Saha, Lena Marions, Per Tornvall
OBJECTIVE: To examine the validity of self-reported endometriosis and to improve the reliability of questionnaires by including endometriosis-related questions. DESIGN: Analysis of survey questionnaire data. SETTING: Cross-sectional study. PATIENT(S): Cohort of 26, 898 female twins aged 20-60 years at interview, who participated in either of two surveys (1998-2002 or 2005-2006). INTERVENTION(S): None...
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27776569/twinning-and-multiple-birth-rates-according-to-maternal-age-in-the-city-of-s%C3%A3-o-paulo-brazil-2003-2014
#18
Emma Otta, Eloisa de S Fernandes, Tiziana G Acquaviva, Tania K Lucci, Leda C Kiehl, Marco A C Varella, Nancy L Segal, Jaroslava V Valentova
The present study investigates the twinning rates in the city of São Paulo, Brazil, during the years 2003-2014. The data were drawn from the Brazilian Health Department database of Sistema de Informações de Nascidos Vivos de São Paulo-SINASC (Live Births Information System of São Paulo). In general, more information is available on the incidence of twinning in developed countries than in developing ones. A total of 24,589 twin deliveries and 736 multiple deliveries were registered in 140 hospitals of São Paulo out of a total of 2,056,016 deliveries during the studied time period...
December 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27774759/psychopathology-in-7-year-old-children-differences-in-maternal-and-paternal-ratings-and-the-genetic-epidemiology
#19
Laura W Wesseldijk, Iryna O Fedko, Meike Bartels, Michel G Nivard, Catharina E M van Beijsterveldt, Dorret I Boomsma, Christel M Middeldorp
The assessment of children's psychopathology is often based on parental report. Earlier studies have suggested that rater bias can affect the estimates of genetic, shared environmental and unique environmental influences on differences between children. The availability of a large dataset of maternal as well as paternal ratings of psychopathology in 7-year old children enabled (i) the analysis of informant effects on these assessments, and (ii) to obtain more reliable estimates of the genetic and non-genetic effects...
October 24, 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/27761665/somatosensory-brain-function-and-gray-matter-regional-volumes-differ-according-to-exercise-history-evidence-from-monozygotic-twins
#20
Pekka Hautasaari, Andrej M Savić, Otto Loberg, Eini Niskanen, Jaakko Kaprio, Urho M Kujala, Ina M Tarkka
Associations between long-term physical activity and cortical function and brain structure are poorly known. Our aim was to assess whether brain functional and/or structural modulation associated with long-term physical activity is detectable using a discordant monozygotic male twin pair design. Nine monozygotic male twin pairs were carefully selected for an intrapair difference in their leisure-time physical activity of at least three years duration (mean age 34 ± 1 years). We registered somatosensory mismatch response (SMMR) in EEG to electrical stimulation of fingers and whole brain MR images...
January 2017: Brain Topography
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