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https://www.readbyqxmd.com/read/29150678/dog-ownership-and-the-risk-of-cardiovascular-disease-and-death-a-nationwide-cohort-study
#1
Mwenya Mubanga, Liisa Byberg, Christoph Nowak, Agneta Egenvall, Patrik K Magnusson, Erik Ingelsson, Tove Fall
Dogs may be beneficial in reducing cardiovascular risk in their owners by providing social support and motivation for physical activity. We aimed to investigate the association of dog ownership with incident cardiovascular disease (CVD) and death in a register-based prospective nation-wide cohort (n = 3,432,153) with up to 12 years of follow-up. Self-reported health and lifestyle habits were available for 34,202 participants in the Swedish Twin Register. Time-to-event analyses with time-updated covariates were used to calculate hazard ratios (HR) with 95% confidence intervals (CI)...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138598/familial-aggregation-of-myasthenia-gravis-in-affected-families-a-population-based-study
#2
Fu-Chao Liu, Chang-Fu Kuo, Lai-Chu See, Hsin-I Tsai, Huang-Ping Yu
Introduction: Myasthenia gravis (MG) is clinically heterogeneous and can be life-threatening if bulbar or respiratory muscles are involved. However, relative contributions of genetic, shared, and nonshared environmental factors to MG susceptibility remain unclear. The aim of this study was to examine the familial aggregation and heritability of MG and the relative risks (RRs) of other autoimmune diseases in the relatives of patients with MG. Methods: A population-based family study using the Taiwan National Health Insurance (NHI) Database was conducted...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29125095/social-comparison-orientation-in-monozygotic-and-dizygotic-twins
#3
Pascal Huguet, Michèle Carlier, Conor V Dolan, Eco J de Geus, Dorret I Boomsma
Twin research has offered evidence that monozygotic (MZ) twins are more socially close than dizygotic (DZ) twins, but has not paid much attention to the way twins compare themselves with their co-twin. The few studies in this area suggest that 'horizontal comparisons' (social comparison motivated by solidarity or communion with others) matter more for MZ twins than for DZ twins, at least when the co-twin is the social comparison standard. Consistent with this view, we predicted higher interest in MZ twins relative to DZ twins to select their co-twin rather than other people in general as the social comparison standard...
November 10, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29119001/a-swedish-national-adoption-study-of-risk-of-irritable-bowel-syndrome-ibs
#4
Rasmus Waehrens, Bengt Zöller, Jan Sundquist, Kristina Sundquist, MirNabi Pirouzifard
Objectives: Irritable bowel syndrome (IBS) clusters in families, but the familial risk of IBS has not been determined in adoptees. Studying adoptees and their biological and adoptive parents is a strong study design for separating genetic from environmental causes of familial clustering. This nationwide study aimed to separate the biological (genetic) and familial environmental contribution to the familial transmission of IBS. Methods: We performed a family study for Swedish-born adoptees born from 1951 until 1995, and their biological and adoptive parents...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29117383/assisted-reproductive-technology-in-europe-2013-results-generated-from-european-registers-by-eshre
#5
C Calhaz-Jorge, C De Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: Are there any changes in the treatments involving ART and IUI initiated in Europe during 2013 compared with previous years? SUMMARY ANSWER: An increase in the overall number of ART cycles resulting from a higher number of countries reporting data was evident, the pregnancy rates (PRs) in 2013 remained stable compared with those reported in 2012, the number of transfers with multiple embryos (3+) was lower than ever before yet the multiple delivery rates (DRs) remained unchanged, and IUI activity and success rates were similar to those of last years...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29108135/regimens-of-ultrasound-surveillance-for-twin-pregnancies-for-improving-outcomes
#6
REVIEW
Jane G Woolcock, Rosalie M Grivell, Jodie M Dodd
BACKGROUND: Increased ultrasound surveillance of twin pregnancies has become accepted practice due to the higher risk of complications. There is no current consensus however as to the method and frequency of ultrasound monitoring that constitutes optimal care. OBJECTIVES: To systematically review the effects of different types and frequency of ultrasound surveillance for women with a twin pregnancy on neonatal, fetal and maternal outcomes. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials...
November 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29072781/diagnostic-and-genetic-overlap-of-three-common-mental-disorders-in-structured-interviews-and-health-registries
#7
F A Torvik, E Ystrom, K Gustavson, T H Rosenström, J G Bramness, N Gillespie, S H Aggen, K S Kendler, T Reichborn-Kjennerud
OBJECTIVE: To investigate whether diagnostic data from structured interviews, primary care and specialist care registries on major depressive disorder (MDD), anxiety disorders (AD) and alcohol use disorder (AUD) identify the same individuals, yield comparable comorbidity estimates and reflect the same genetic influences. METHODS: Registry data from primary and specialist care were available for 11 727 twins and diagnostic interview data for 2271 of these. We used logistic regression analyses and biometric modelling to investigate the overlap between the data sources...
October 26, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29058931/genetic-and-environmental-contributions-to-the-development-of-childhood-aggression
#8
Gitta H Lubke, Daniel B McArtor, Dorret I Boomsma, Meike Bartels
Longitudinal data from a large sample of twins participating in the Netherlands Twin Register (n = 42,827, age range 3-16) were analyzed to investigate the genetic and environmental contributions to childhood aggression. Genetic auto-regressive (simplex) models were used to assess whether the same genes are involved or whether new genes come into play as children grow up. The authors compared 2 different simplex models to disentangle potentially changing behavioral expressions from changes in genetic and environmental effects...
October 23, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29043520/an-extended-twin-pedigree-study-of-neuroticism-in-the-netherlands-twin-register
#9
Dorret I Boomsma, Quinta Helmer, Harold A Nieuwboer, Jouke Jan Hottenga, Marleen H de Moor, Stéphanie M van den Berg, Gareth E Davies, Jacqueline M Vink, Maarten J Schouten, Conor V Dolan, Gonneke Willemsen, Meike Bartels, Toos C E M van Beijsterveldt, Lannie Ligthart, Eco J de Geus
For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores...
October 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29039147/heritability-of-addison-s-disease-and-prevalence-of-associated-autoimmunity-in-a-cohort-of-112-100-swedish-twins
#10
Jakob Skov, Jonas Höijer, Patrik K E Magnusson, Jonas F Ludvigsson, Olle Kämpe, Sophie Bensing
PURPOSE: The pathophysiology behind autoimmune Addison's disease (AAD) is poorly understood, and the relative influence of genetic and environmental factors remains unclear. In this study, we examined the heritability of AAD and explored disease-associated autoimmune comorbidity among Swedish twins. METHODS: A population-based longitudinal cohort of 112,100 Swedish twins was used to calculate the heritability of AAD, and to explore co-occurrence of 10 organ-specific autoimmune disorders in twin pairs with AAD...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29032743/adverse-outcomes-of-sick-leave-due-to-mental-disorders-a-prospective-study-of-discordant-twin-pairs
#11
Lisa Mather, Victoria Blom, Gunnar Bergström, Pia Svedberg
AIMS: The aim of this study was to investigate whether sick leave due to different mental disorders increased the risk of reoccurring sick-leave, disability pension and unemployment, taking genetics and shared environment into account. METHODS: This register-based cohort study contains 2202 discordant twin pairs 18-64 years old, where one twin had sick leave due to a mental disorder 2005-2006. The end of the sick-leave spell was the start of follow-up for both twins...
October 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29021003/seasonality-in-multiple-maternities
#12
Johan Fellman
In the 19th century, a series of international statistical congresses introduced common rules for the national demographic registers. This activity contributed to the genesis of statistical research. During the history of twin research, Hellin's law has played a central role because it is an approximately correct association between the rates of multiple maternities. However, it has been mathematically proven that Hellin's law cannot hold exactly. The majority of all studies of Hellin's law are based on empirical rates of multiple maternities...
October 12, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28987712/heritability-of-schizophrenia-and-schizophrenia-spectrum-based-on-the-nationwide-danish-twin-register
#13
Rikke Hilker, Dorte Helenius, Birgitte Fagerlund, Axel Skytthe, Kaare Christensen, Thomas M Werge, Merete Nordentoft, Birte Glenthøj
BACKGROUND: Twin studies have provided evidence that both genetic and environmental factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples have varied methodologically. This study provides updated heritability estimates based on nationwide twin data and an improved statistical methodology. METHODS: Combining two nationwide registers, the Danish Twin Register and the Danish Psychiatric Research Register, we identified a sample of twins born between 1951 and 2000 (N = 31,524 twin pairs)...
September 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28981984/obstetrical-complications-in-dichorionic-twin-pregnancies-in-women-with-polycystic-ovary-syndrome
#14
Fjola Jonsdottir, Lisbeth Nilas, Kirsten R Andreasen, Jørgen Grinsted, Michael Christiansen, Paula L Hedley, Klara V Naver
INTRODUCTION: Both women with polycystic ovary syndrome (PCOS) and women with twin pregnancies have increased risk of adverse pregnancy outcome. The aim of this study was to investigate the impact of PCOS and maternal androgen levels on the outcome of dichorionic twin pregnancy. MATERIAL AND METHODS: A retrospective study of 360 women with dichorionic twin pregnancies: 72 women with PCOS from a fertility clinic (years 1997-2010) and 288 women without PCOS from a hospital cohort (years 2005-2007)...
October 5, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28980316/cerebral-palsy-after-assisted-reproductive-technology-a-cohort-study
#15
Shona Goldsmith, Sarah Mcintyre, Nadia Badawi, Michele Hansen
AIM: To calculate the birth prevalence of cerebral palsy (CP) after assisted reproductive technology (ART) and compare the clinical outcomes of children with CP after ART or natural conception. METHOD: This cohort study used linked CP and ART register data from live births in Western Australia (1994-2002). Birth prevalence was calculated and data analysed using descriptive statistics and logistic regression. It was adjusted for confounding variables and stratified by plurality and gestational age...
October 4, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28969391/migraine-and-risk-of-stroke-a-national-population-based-twin-study
#16
Maria Lantz, Johanna Sieurin, Arvid Sjölander, Elisabet Waldenlind, Christina Sjöstrand, Karin Wirdefeldt
Numerous studies have indicated an increased risk for stroke in patients with migraine, especially migraine with aura; however, many studies used self-reported migraine and only a few controlled for familial factors. We aimed to investigate migraine as a risk factor for stroke in a Swedish population-based twin cohort, and whether familial factors contribute to an increased risk. The study population included twins without prior cerebrovascular disease who answered a headache questionnaire during 1998 and 2002 for twins born 1935-58 and during 2005-06 for twins born between 1959 and 1985...
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28951572/heritability-of-siesta-and-night-time-sleep-as-continuously-assessed-by-a-circadian-related-integrated-measure
#17
J Lopez-Minguez, J J Morosoli, J A Madrid, M Garaulet, J R Ordoñana
Siesta is a relevant aspect of sleep due to its posited relationship with health or cognitive function. However, unlike night-time sleep, studies about daytime-sleep determinants and characteristics are scarce, and the genetic/environmental structure of siesta is still unknown. Our aim was to explore the relative contribution of genetic and environmental factors to variation in sleep-wake rhythm, measured by a continuous assessment of temperature-activity-position (TAP), which allows for diurnal sleep analysis...
September 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28939060/familial-aggregation-of-nasopharyngeal-carcinoma-in-taiwan
#18
Shiang-Fu Huang, Jen-Hao Hsiao, Chi-Kuan Young, Hui-Tzu Chien, Chang-Fu Kuo, Lai-Chu See, Shue-Fen Luo, Lu-Hsiang Huang, Chun-Ta Liao, Tung-Chieh Joseph Chang
BACKGROUND: The incidence of nasopharyngeal carcinoma (NPC) is higher in Chinese than in Caucasian populations. Genetic, viral, and lifestyle factors may explain these ethnic differences in the incidence of NPC. In the present study, we examined the familial aggregation, heritability, and relative risks (RRs) of NPC using a nationwide database in Taiwan. METHODS: A population-based family study was conducted using the Taiwan National Health Insurance Research Database...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28936587/metabolite-ratios-as-potential-biomarkers-for-type-2-diabetes-a-direct-study
#19
Sophie Molnos, Simone Wahl, Mark Haid, E Marelise W Eekhoff, René Pool, Anna Floegel, Joris Deelen, Daniela Much, Cornelia Prehn, Michaela Breier, Harmen H Draisma, Nienke van Leeuwen, Annemarie M C Simonis-Bik, Anna Jonsson, Gonneke Willemsen, Wolfgang Bernigau, Rui Wang-Sattler, Karsten Suhre, Annette Peters, Barbara Thorand, Christian Herder, Wolfgang Rathmann, Michael Roden, Christian Gieger, Mark H H Kramer, Diana van Heemst, Helle K Pedersen, Valborg Gudmundsdottir, Matthias B Schulze, Tobias Pischon, Eco J C de Geus, Heiner Boeing, Dorret I Boomsma, Anette G Ziegler, P Eline Slagboom, Sandra Hummel, Marian Beekman, Harald Grallert, Søren Brunak, Mark I McCarthy, Ramneek Gupta, Ewan R Pearson, Jerzy Adamski, Leen M 't Hart
AIMS/HYPOTHESIS: Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabetes...
September 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/28923532/cognitive-trajectories-in-relation-to-hospitalization-among-older-swedish-adults
#20
Jenny Hallgren, Eleonor I Fransson, Chandra A Reynolds, Deborah Finkel, Nancy L Pedersen, Anna K Dahl Aslan
INTRODUCTION: Research indicate that cognitive impairment might be related to hospitalization, but little is known about these effects over time. OBJECTIVE: To assess cognitive change before and after hospitalization among older adults in a population-based longitudinal study with up to 25 years of follow-up. METHOD: A longitudinal study on 828 community living men and women aged 50-86 from the Swedish Adoption/Twin Study of Ageing (SATSA) were linked to The Swedish National Inpatient Register...
September 9, 2017: Archives of Gerontology and Geriatrics
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