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JOURNAL ARTICLE
Paritha Arumugam, Brenna C Carey, Kathryn A Wikenheiser-Brokamp, Jeffrey Krischer, Matthew Wessendarp, Kenjiro Shima, Claudia Chalk, Jennifer Stock, Yan Ma, Diane Black, Michelle Imbrogno, Margaret Collins, Dan Justin Kalenda Yombo, Haripriya Sakthivel, Takuji Suzuki, Carolyn Lutzko, Jose A Cancelas, Michelle Adams, Elizabeth Hoskins, Dawn Lowe-Daniels, Lilith Reeves, Anne Kaiser, Bruce C Trapnell
Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), a surfactant accumulation disorder caused by mutations in CSF2RA/B (and murine homologs). We conducted a toxicology study of PMT of Csf2ra gene-corrected macrophages (mGM-Rα+ Mϕs) or saline-control intervention in Csf2ra KO or wild-type (WT) mice including single ascending dose and repeat ascending dose studies evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics...
June 13, 2024: Molecular Therapy. Methods & Clinical Development
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JOURNAL ARTICLE
Laura C Myers, Ithan D Peltan, Khanh K Thai, Patricia Kipnis, Manisha Desai, Ycar Devis, Heather Clancy, Yun W Lu, Samuel M Brown, Alan S Go, Romain S Neugebauer, Vincent X Liu, Allan J Walkey
BACKGROUND: New-onset atrial fibrillation (AF) during sepsis is common, but models designed to stratify stroke risk excluded patients with secondary AF. We assessed the predictive validity of CHA2 DS2 VASc scores among patients with new-onset AF during sepsis and developed a novel stroke prediction model incorporating presepsis and intrasepsis characteristics. METHODS: We included patients ≥40 years old who survived hospitalizations with sepsis and new-onset AF across 21 Kaiser Permanente Northern California hospitals from January 1, 2011 to September 30, 2017...
April 9, 2024: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
#23
JOURNAL ARTICLE
Leonie Schouten, Frank Petzke, Anne Gärtner, Bernd Nagel, Ulrike Kaiser
BACKGROUND: Secondary preventive outpatient diagnostic services for patients with pain and risk factors for chronification have not yet been sufficiently established. In the PAIN2020 project (Innovation Fund, 01NVF17049) an outpatient interdisciplinary multimodal assessment (IMA) was introduced for the first time early in the course of the disease. OBJECTIVE: For the implementation of the IMA procedures for team cooperation and decision criteria were developed, which were implemented by a team of medical, physiotherapeutic and psychological therapists...
April 9, 2024: Der Schmerz
#24
JOURNAL ARTICLE
Li Xu, Jessi R Prentice, Raul Velez-Montoya, Alina Sinha, Mark R Barakat, Ashwin Gupta, Robert Lowenthal, Arshad M Khanani, Peter K Kaiser, Jeffrey S Heier, Anthony Jones, Joshua L Morgenstern, Anne Strong Caldwell, Niklaus Mueller, Hugo Quiroz-Mercado, Michael Huvard, Jeffrey L Olson, Ramesh Bhatt, Ramanath Bhandari
OBJECTIVE: To investigate preclinical data regarding the efficacy and biocompatibility of a bispecific protein, RO-101, with effects on VEGF-A and angiopoietin-2 (Ang-2) for use in retinal diseases. DESIGN: Experimental study. SUBJECTS: Brown Norway rats and New Zealand White Cross rabbits. METHODS: Preclinical study data of RO-101 in terms of target-specific enzyme-linked immunosorbent assay binding affinity to VEGF-A and Ang-2, vitreous half-life, inhibition of target-receptor interaction, laser choroidal neovascular membrane animal model, human umbilical vein endothelial cell migration, and biocompatibility was obtained...
2024: Ophthalmol Sci
#25
JOURNAL ARTICLE
Ibrahim Sales, Yazed AlRuthia
BACKGROUND: Adherence to prescription medications is vital to the success of any treatment plan, especially for chronic health conditions, such as hypertension (HTN). Although there are different scales used in assessing adherence to prescription medications, most if not all, of those scales are not available in Arabic. The absence of essential assessment tools makes the appraisal of adherence to prescription medications very difficult for native Arabic speakers. Therefore, this study aimed to translate and validate the Hill-Bone Compliance to High Blood Pressure Therapy (CHBPT) scale, which is commonly used to assess adherence to antihypertensive medications, among a sample of Arabic-speaking patients with HTN...
May 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
#26
JOURNAL ARTICLE
Irvin Lien, Howard Moffet, Jennifer Liu, Andrew Karter, Matthew Solomon, Alan Go, Khurram Nasir, Stephen Sidney, Jamal Rana
INTRODUCTION: The American Heart Association Life's Simple 7 schema can be used to categorize patients' cardiovascular health status as poor, intermediate, or ideal on the basis of smoking, BMI, physical activity, dietary patterns, blood pressure, cholesterol, and fasting blood sugar. This study examined the association between cardiovascular health status and subsequent healthcare utilization. METHODS: This was an observational cohort study of adults from an integrated healthcare delivery system-Kaiser Permanente Northern California-that had outpatient care between 2013 and 2014...
June 2024: AJPM Focus
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JOURNAL ARTICLE
Oliver Schwartz, Katharina Vill, Michelle Pfaffenlehner, Max Behrens, Claudia Weiß, Jessika Johannsen, Johannes Friese, Andreas Hahn, Andreas Ziegler, Sabine Illsinger, Martin Smitka, Arpad von Moers, Heike Kölbel, Gudrun Schreiber, Nadja Kaiser, Ekkehard Wilichowski, Marina Flotats-Bastardas, Ralf A Husain, Matthias Baumann, Cornelia Köhler, Regina Trollmann, Annette Schwerin-Nagel, Astrid Eisenkölbl, Mareike Schimmel, Martin Fleger, Birgit Kauffmann, Gert Wiegand, Manuela Baumgartner, Christian Rauscher, Sebahattin Cirak, Dieter Gläser, Günther Bernert, Tim Hagenacker, Susanne Goldbach, Kristina Probst-Schendzielorz, Hanns Lochmüller, Wolfgang Müller-Felber, Ulrike Schara-Schmidt, Maggie C Walter, Janbernd Kirschner, Astrid Pechmann
IMPORTANCE: There is increasing evidence that early diagnosis and treatment are key for outcomes in infants with spinal muscular atrophy (SMA), and newborn screening programs have been implemented to detect the disease before onset of symptoms. However, data from controlled studies that reliably confirm the benefits of newborn screening are lacking. OBJECTIVE: To compare data obtained on patients with SMA diagnosed through newborn screening and those diagnosed after clinical symptom onset...
April 8, 2024: JAMA Pediatrics
#28
Antonia Susnjar, Antonia Kaiser, Dunja Simicic, Gianna Nossa, Alexander Lin, Georg Oeltzschner, Aaron Gudmundson
A recent expert consensus found that non-standard reporting in MRS studies led to poor reproducibility. In order to address this, MRSinMRS guidelines were introduced; however, because of the disparate nomenclature and data formats, adoption has been slow. To get around this problem, REMY, a toolbox that supports major vendor formats, was created. By efficiently filling in important fields in the MRSinMRS table, it improves reproducibility. Even with certain hardware-related restrictions, REMY makes a substantial contribution to the completion of acquisition parameters, which facilitates reporting...
March 28, 2024: ArXiv
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JOURNAL ARTICLE
Marco Schiavone, Alessio Gasperetti, Paolo Compagnucci, Julia Vogler, Mikael Laredo, Elisabetta Montemerlo, Simone Gulletta, Alexander Breitenstein, Matteo Ziacchi, Martin Martinek, Michela Casella, Pietro Palmisano, Lukas Kaiser, Carlo Lavalle, Leonardo Calò, Sebastian Seidl, Ardan M Saguner, Giovanni Rovaris, Jürgen Kuschyk, Mauro Biffi, Luigi Di Biase, Antonio Dello Russo, Claudio Tondo, Paolo Della Bella, Roland Tilz, Giovanni B Forleo
AIMS: Catheter ablation (CA) of ventricular tachycardia (VT) has become an important tool to improve clinical outcomes in patients with appropriate transvenous implantable cardioverter defibrillator (ICD) shocks. The aim of our analysis was to test whether VT ablation (VTA) impacts long-term clinical outcomes even in subcutaneous ICD (S-ICD) carriers. METHODS AND RESULTS: International Subcutaneous Implantable Cardioverter Defibrillator (iSUSI) registry patients who experienced either an ICD shock or a hospitalization for monomorphic VT were included in this analysis...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#30
JOURNAL ARTICLE
M Zhao, G G Chen, H L Zhang, Q R Li, L Y Zhou, Y Li, J Yang, J X Wu, Y L Li, H Huangfu
Objective: To develop a simple screening questionnaire for persistent postural-perceptual dizziness (PPPD) and evaluate its screening ability. Methods: A convenience sample of 296 individuals who met the inclusion criteria between November 2021 and January 2023 were prospectively selected for three rounds of screening at the Vertigo Specialty Clinic of the Department of Otorhinolaryngology-Head and Neck Surgery in the First Hospital of Shanxi Medical University. In conjunction with expert opinion and statistical analysis, the first and second rounds of screening were used to modify and finalize the questionnaire entries, and the third round of screening was used to evaluate the questionnaire's screening ability...
April 9, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
#31
JOURNAL ARTICLE
Neal H Shorstein, Shannon E McCabe, Mubarika Alavi, Marilyn L Kwan, Naveen S Chandra
PURPOSE: To compare the effectiveness and safety of a single injection of subconjunctival triamcinolone acetonide (TA) to postoperative topical prednisolone acetate (PA) with and without nonsteroidal anti-inflammatory drug (NSAID) for cataract surgery prophylaxis DESIGN: Retrospective comparative effectiveness cohort study PARTICIPANTS: Patients undergoing phacoemulsification cataract surgery at Kaiser Permanente Northern California from 2018 through 2021 INTERVENTION: Anti-inflammatory prophylaxis exposure groups included topical PA with or without NSAID, and subconjunctival injection of TA (Kenalog®) 10 mg/mL or 40 mg/mL in low (1...
April 4, 2024: Ophthalmology
#32
JOURNAL ARTICLE
Armin Niklas Flinspach, Florian Jürgen Raimann, Philipp Kaiser, Michaela Pfaff, Kai Zacharowski, Vanessa Neef, Elisabeth Hannah Adam
BACKGROUND: Optimal intensive care of patients undergoing valve surgery is a complex balancing act between sedation for monitoring and timely postoperative awakening. It remains unclear, if these requirements can be fulfilled by volatile sedations in intensive care medicine in an efficient manner. Therefore, this study aimed to assess the time to extubation and secondary the workload required. METHODS: We conducted a prospective randomized single-center trial at a tertiary university hospital to evaluate the postoperative management of open valve surgery patients...
April 5, 2024: Critical Care: the Official Journal of the Critical Care Forum
#33
JOURNAL ARTICLE
Joseph Kazibwe, Phuong Bich Tran, Andrea Hannah Kaiser, Simon Peter Kasagga, Felix Masiye, Björn Ekman, Jesper Sundewall
BACKGROUND: Low- and middle-income countries have committed to achieving universal health coverage (UHC) as a means to enhance access to services and improve financial protection. One of the key health financing reforms to achieve UHC is the introduction or expansion of health insurance to enhance access to basic health services, including maternal and reproductive health care. However, there is a paucity of evidence of the extent to which these reforms have had impact on the main policy objectives of enhancing service utilization and financial protection...
April 5, 2024: BMC Health Services Research
#34
JOURNAL ARTICLE
Rex A Parker, Yichen Zhou, Eric J Puttock, Wansu Chen, Eva Lustigova, Bechien U Wu
PURPOSE: Magnetic resonance imaging has been recommended as a primary imaging modality among high-risk individuals undergoing screening for pancreatic cancer. We aimed to delineate potential precursor lesions for pancreatic cancer on MR imaging. METHODS: We conducted a case-control study at Kaiser Permanente Southern California (2008-2018) among patients that developed pancreatic cancer who had pre-diagnostic MRI examinations obtained 2-36 months prior to cancer diagnosis (cases) matched 1:2 by age, gender, race/ethnicity, contrast status and year of scan (controls)...
April 5, 2024: Abdominal Radiology
#35
JOURNAL ARTICLE
Ming Lee, Rebecca E Kaiser, Christopher D Armstrong, David B Dukenik, Deborah Soong, Nancy S Elliott, Raymond R Balise, Erin N Kobetz, Justin Taylor
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#36
JOURNAL ARTICLE
Ming Lee, Rebecca Kaiser, Christopher Armstrong, Nancy Elliott, Justin Taylor, Raymond Balise, Erin Kobetz
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#37
JOURNAL ARTICLE
Melissa Thalhammer, Julia Schulz, Felicitas Scheulen, Mohamed El Mehdi Oubaggi, Matthias Kirschner, Stefan Kaiser, André Schmidt, Stefan Borgwardt, Mihai Avram, Felix Brandl, Christian Sorg
BACKGROUND AND HYPOTHESIS: Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant thalamic nuclei volume across the spectrum and examined its potential associations with cognitive symptoms. STUDY DESIGN: We performed a FreeSurfer-based volumetry of T1-weighted brain MRIs from 137 healthy controls, 66 at-risk mental state (ARMS) subjects, 89 first-episode psychosis (FEP) individuals, and 126 patients with schizophrenia to estimate thalamic nuclei volumes of six nuclei groups (anterior, lateral, ventral, intralaminar, medial, and pulvinar)...
April 5, 2024: Schizophrenia Bulletin
#38
JOURNAL ARTICLE
Laura Schulte, Pia Oswald, Max Mühlenhaupt, Edith Ossendorf, Sabine Kruse, Sylvia Kaiser, Barbara A Caspers
The larvae of the European fire salamander ( Salamandra salamandra ) can inhabit two different habitats: streams and ponds. Streams are characterized by lower predation risks and higher food availability. Thus, ponds are considered a less suitable habitat. To investigate the differential impacts of these two habitats on larval physiology, we measured the stress response of larvae. After successfully validating the measure of water-borne corticosterone release rates in fire salamander larvae, we measured the baseline and stress-induced corticosterone of 64 larvae from ponds and streams in the field...
April 2024: Royal Society Open Science
#39
JOURNAL ARTICLE
Bradley K Ackerson, Katia J Bruxvoort, Lei Qian, Lina S Sy, Sijia Qiu, Julia E Tubert, Gina S Lee, Jennifer H Ku, Ana Florea, Yi Luo, Radha Bathala, Julie Stern, Soon K Choi, Harpreet S Takhar, Michael Aragones, Morgan A Marks, Evan J Anderson, Cindy Ke Zhou, Tianyu Sun, Carla A Talarico, Hung Fu Tseng
Emerging SARS-CoV-2 sublineages continue to cause serious COVID-19 disease, but most individuals have not received any COVID-19 vaccine for >1 year. Assessment of long-term effectiveness of bivalent COVID-19 vaccines against circulating sublineages is important to inform the potential need for vaccination with updated vaccines. In this test-negative study at Kaiser Permanente Southern California, sequencing-confirmed BA.4/BA.5- or XBB-related SARS-CoV-2-positive cases (September 1, 2022 to June 30, 2023), were matched 1:3 to SARS-CoV-2-negative controls...
December 31, 2024: Human Vaccines & Immunotherapeutics
#40
JOURNAL ARTICLE
Francesca Trotta, Francesco Petrosino, Gianluca Pucciarelli, Rosaria Alvaro, Ercole Vellone, Davide Bartoli
BACKGROUND: The presence of family members in an isolated ICU during an isolation disease outbreak is restricted by hospital policies because of the infectious risk. This can be overcome by conferring to family members the skill and the ability to safely don and doff the personal protective equipment (PPE) through a nurse-led training intervention and assess their satisfaction, to respond to the need to define a safe, effective and quality care pathway focused on Family-Centered Care (FCC) principles...
April 3, 2024: Heart & Lung: the Journal of Critical Care
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