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https://www.readbyqxmd.com/read/27900541/tendon-transfer-to-unossified-bone-in-a-porcine-model-potential-implications-for-early-tibialis-anterior-tendon-transfers-in-children-with-clubfeet
#1
Matthew A Halanski, Sam Abrams, Rachel Lenhart, Ellen Leiferman, Teresa Kaiser, Emily Pierce, Rachel Rebekah Franklin, Dayton Opel, Kenneth J Noonan, Thomas D Crenshaw
PURPOSE: Tibialis anterior tendon transfers (TATT) are commonly performed in young children following Ponseti casting for clubfeet. The classic TATT involves advancing the tendon through a hole drilled in the ossified cuneiform. The aim of this study was to determine if tendons transferred through unossified bones have untoward effects on subsequent bone development. METHOD: Twenty-five piglets underwent one of five surgical procedures. An 18-gauge needle was then used to place a tunnel through the bony or cartilaginous portion of the calcaneus (through direct visualization) and isolated slips of the flexor digitorum superficialis (FDS) were placed through the tunnels, as determined by surgical procedure...
November 30, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27899398/feasibility-qualitative-findings-and-satisfaction-of-a-brief-tai-chi-mind-body-programme-for-veterans-with-post-traumatic-stress-symptoms
#2
Barbara L Niles, DeAnna L Mori, Craig P Polizzi, Anica Pless Kaiser, Annie M Ledoux, Chenchen Wang
OBJECTIVE: To examine feasibility, qualitative feedback and satisfaction associated with a 4-session introduction to Tai Chi for veterans with post-traumatic stress symptoms. DESIGN: We observed and reported recruitment and retention rates, participant characteristics, adherence, and satisfaction across 2 cohorts. We also examined qualitative feedback provided by questionnaires, focus groups and individual interviews. MAIN OUTCOME MEASURES: Rates of recruitment and retention, focus group and individual feedback interviews, self-reported satisfaction...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27899076/the-kaiser-permanente-northern-california-research-program-on-genes-environment-and-health-rpgeh-pregnancy-cohort-study-design-methodology-and-baseline-characteristics
#3
M M Hedderson, A Ferrara, L A Avalos, S K Van den Eeden, E P Gunderson, D K Li, A Altschuler, S Woo, S Rowell, V Choudhary, F Xu, T Flanagan, C Schaefer, L A Croen
BACKGROUND: Exposures during the prenatal period may have lasting effects on maternal and child health outcomes. To better understand the effects of the in utero environment on children's short- and long-term health, large representative pregnancy cohorts with comprehensive information on a broad range of environmental influences (including biological and behavioral) and the ability to link to prenatal, child and maternal health outcomes are needed. The Research Program on Genes, Environment and Health (RPGEH) pregnancy cohort at Kaiser Permanente Northern California (KPNC) was established to create a resource for conducting research to better understand factors influencing women's and children's health...
November 29, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27896878/the-relationship-between-leadership-style-and-nurse-to-nurse-incivility-turning-the-lens-inward
#4
Jennifer A Kaiser
AIM: The aim of this study was to examine the impact of leadership styles on the reported rates of lateral hostility in nurses. BACKGROUND: Previous explanations of horizontal incivility point to oppressed group behaviour and socialisation of nurses. Leadership and organisational culture are known to have a profound impact on workplace behaviour, yet few studies have examined the relationship between leadership style and nurse-to-nurse incivility. METHODS: A survey was used to assess the perceived levels of incivility and the leadership styles experienced by 237 participants defined as 'staff nurses'...
November 29, 2016: Journal of Nursing Management
https://www.readbyqxmd.com/read/27896876/sites-of-recurrence-in-patients-following-clearance-of-psoriasis-with-biologic-therapy
#5
D J No, M Amin, S P Reddy, A Egeberg, J J Wu
Management of psoriasis has vastly improved since the emergence of biologic medications, however such drugs tend to lose effectiveness with extended use.(1) We assessed the distribution of psoriatic lesions that reoccur in patients who experienced a loss of efficacy from their biologic medication. This retrospective chart review focused on patients with psoriasis who presented to Kaiser Permanente Los Angeles Medical Center from January 2008 to September 2016. This article is protected by copyright. All rights reserved...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27894312/release-of-copper-amended-particles-from-micronized-copper-pressure-treated-wood-during-mechanical-abrasion
#6
Chiara Civardi, Lukas Schlagenhauf, Jean-Pierre Kaiser, Cordula Hirsch, Claudio Mucchino, Adrian Wichser, Peter Wick, Francis W M R Schwarze
BACKGROUND: We investigated the particles released due to abrasion of wood surfaces pressure-treated with micronized copper azole (MCA) wood preservative and we gathered preliminary data on its in vitro cytotoxicity for lung cells. The data were compared with particles released after abrasion of untreated, water (0% MCA)-pressure-treated, chromated copper (CC)-pressure-treated wood, and varnished wood. Size, morphology, and composition of the released particles were analyzed. RESULTS: Our results indicate that the abrasion of MCA-pressure-treated wood does not cause an additional release of nanoparticles from the unreacted copper (Cu) carbonate nanoparticles from of the MCA formulation...
November 28, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27893896/association-between-influenza-infection-and-vaccination-during-pregnancy-and-risk-of-autism-spectrum-disorder
#7
Ousseny Zerbo, Yinge Qian, Cathleen Yoshida, Bruce H Fireman, Nicola P Klein, Lisa A Croen
Importance: Maternal infections and fever during pregnancy are associated with increased risk for autism spectrum disorders (ASDs). To our knowledge, no study has investigated the association between influenza vaccination during pregnancy and ASD. Objective: To investigate the association between influenza infection and vaccination during pregnancy and ASD risk. Design, Setting, and Participants: This cohort study included 196 929 children born at Kaiser Permanente Northern California from January 1, 2000 to December 31, 2010, at a gestational age of at least 24 weeks...
November 28, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27890922/progress-in-imaging-methods-insights-gained-into-plasmodium-biology
#8
Mariana De Niz, Paul-Christian Burda, Gesine Kaiser, Hernando A Del Portillo, Tobias Spielmann, Freddy Frischknecht, Volker T Heussler
Over the past decade, major advances in imaging techniques have enhanced our understanding of Plasmodium spp. parasites and their interplay with mammalian hosts and mosquito vectors. Cryoelectron tomography, cryo-X-ray tomography and super-resolution microscopy have shifted paradigms of sporozoite and gametocyte structure, the process of erythrocyte invasion by merozoites, and the architecture of Maurer's clefts. Intravital time-lapse imaging has been revolutionary for our understanding of pre-erythrocytic stages of rodent Plasmodium parasites...
November 28, 2016: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/27890584/a-sedge-plant-as-the-source-of-kangaroo-island-propolis-rich-in-prenylated-p-coumarate-ester-and-stilbenes
#9
Colin C Duke, Van H Tran, Rujee K Duke, Abdallah Abu-Mellal, George T Plunkett, Douglas I King, Kaiser Hamid, Karen L Wilson, Russell L Barrett, Jeremy J Bruhl
Propolis samples from Kangaroo Island, South Australia, were investigated for chemical constituents using high-field nuclear magnetic resonance spectral profiling. A type of propolis was found containing a high proportion of prenylated hydroxystilbenes. Subsequently, the botanical origin of this type of propolis was identified using a beehive propolis depletion method and analysis of flora. Ligurian honey bees, Apis mellifera ligustica Spinola, were found to produce propolis from resin exuded by the Australian native sedge plant Lepidosperma sp...
November 24, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27888262/search-for-an-animal-model-to-investigate-selective-pulmonary-vasodilation
#10
Bodil Petersen, Thilo Busch, Katharina Noreikat, Lorenz Homeister, Ralf Regenthal, Udo X Kaisers
Pulmonary arterial hypertension is a life-threatening disease with a poor prognosis. Oral treatment with vasodilators is often limited by systemic hypotension. Inhalation of vasodilators offers the opportunity for selective pulmonary vasodilation. Testing selective pulmonary vasodilation by inhaled nitric oxide or alternative substances in animal models requires an increased pulmonary vascular tone. The aim of this study was to identify animal models that are suitable for investigating selective pulmonary vasodilation...
November 25, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27888200/effect-of-principal-component-analysis-centering-and-scaling-on-classification-of-mycobacteria-from-raman-spectra
#11
Cynthia Hanson, Michael Sieverts, Elizabeth Vargis
Raman spectroscopy has been used for decades to detect and identify biological substances as it provides specific molecular information. Spectra collected from biological samples are often complex, requiring the aid of data truncation techniques such as principal component analysis (PCA) and multivariate classification methods. Classification results depend on the proper selection of principal components (PCs) and how PCA is performed (scaling and/or centering). There are also guidelines for choosing the optimal number of PCs such as a scree plot, Kaiser criterion, or cumulative percent variance...
November 25, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27884612/enucleation-a-treatment-alternative-for-branch-duct-intraductal-papillary-mucinous-neoplasms
#12
Joerg Kaiser, Stefan Fritz, Miriam Klauss, Frank Bergmann, Ulf Hinz, Oliver Strobel, Lutz Schneider, Markus W Büchler, Thilo Hackert
BACKGROUND: Small, asymptomatic, branch-duct intraductal papillary mucinous neoplasms of the pancreas are often kept under surveillance despite their malignant potential. The management of branch-duct intraductal papillary mucinous neoplasm is controversial with regard to indications and extent of any operative intervention. The present study aimed to evaluate enucleation as an alternative operative approach for branch-duct intraductal papillary mucinous neoplasms to exclude and prevent malignancy...
November 21, 2016: Surgery
https://www.readbyqxmd.com/read/27882933/multiple-myeloma-risk-variant-at-7p15-3-creates-an-irf4-binding-site-and-interferes-with-cdca7l-expression
#13
Ni Li, David C Johnson, Niels Weinhold, James B Studd, Giulia Orlando, Fabio Mirabella, Jonathan S Mitchell, Tobias Meissner, Martin Kaiser, Hartmut Goldschmidt, Kari Hemminki, Gareth J Morgan, Richard S Houlston
Genome-wide association studies have identified several risk loci for multiple myeloma (MM); however, the mechanisms by which they influence MM are unknown. Here by using genetic association data and functional characterization, we demonstrate that rs4487645 G>T, the most highly associated variant (P = 5.30 × 10(-25)), resides in an enhancer element 47 kb upstream of the transcription start site of c-Myc-interacting CDCA7L. The G-risk allele, associated with increased CDCA7L expression (P=1.95 × 10(-36)), increases IRF4 binding and the enhancer interacts with the CDCA7L promoter...
November 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27876020/the-brief-negative-symptom-scale-validation-of-the-german-translation-and-convergent-validity-with-self-rated-anhedonia-and-observer-rated-apathy
#14
Martin Bischof, Caitriona Obermann, Matthias N Hartmann, Oliver M Hager, Matthias Kirschner, Agne Kluge, Gregory P Strauss, Stefan Kaiser
BACKGROUND: Negative symptoms are considered core symptoms of schizophrenia. The Brief Negative Symptom Scale (BNSS) was developed to measure this symptomatic dimension according to a current consensus definition. The present study examined the psychometric properties of the German version of the BNSS. To expand former findings on convergent validity, we employed the Temporal Experience Pleasure Scale (TEPS), a hedonic self-report that distinguishes between consummatory and anticipatory pleasure...
November 22, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27874262/a-deep-hydrophobic-binding-cavity-is-the-main-interaction-for-different-y2-r-antagonists
#15
Kerstin Burkert, Tristan Zellmann, René Meier, Anette Kaiser, Jan Stichel, Jens Meiler, Gopi K Mittapalli, Edward Roberts, Annette G Beck-Sickinger
The neuropeptide Y2 receptor (Y2 R) is involved in various pathophysiological processes such as epilepsy, mood disorders, angiogenesis, and tumor growth. Therefore, the Y2 R is an interesting target for drug development. A detailed understanding of the binding pocket could facilitate the development of highly selective antagonists to study the role of Y2 R in vitro and in vivo. In this study, several residues crucial to the interaction of BIIE0246 and SF-11 derivatives with Y2 R were investigated by signal transduction assays...
November 22, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27874006/fission-and-fusion-scenarios-for-magnetic-microswimmer-clusters
#16
Francisca Guzmán-Lastra, Andreas Kaiser, Hartmut Löwen
Fission and fusion processes of particle clusters occur in many areas of physics and chemistry from subnuclear to astronomic length scales. Here we study fission and fusion of magnetic microswimmer clusters as governed by their hydrodynamic and dipolar interactions. Rich scenarios are found that depend crucially on whether the swimmer is a pusher or a puller. In particular a linear magnetic chain of pullers is stable while a pusher chain shows a cascade of fission (or disassembly) processes as the self-propulsion velocity is increased...
November 22, 2016: Nature Communications
https://www.readbyqxmd.com/read/27871681/postoperative-antibiotic-use-and-the-incidence-of-intra-abdominal-abscess-in-the-setting-of-suppurative-appendicitis-a-retrospective-analysis
#17
Esther Bae, Ahmed Dehal, Vanessa Franz, Michael Joannides, Nicholas Sakis, Joshua Scurlock, Patrick Nguyen, Farabi Hussain
BACKGROUND: Although guidelines exist for postoperative antibiotic use in acute appendicitis that is perforated, gangrenous, or simple/uncomplicated, there are less data about its use in suppurative appendicitis. Here, we targeted this subgroup of patients to determine whether postoperative antibiotic administration affects incidence of intra-abdominal abscess formation. METHODS: We retrospectively examined 1,192 patients who underwent laparoscopic appendectomy for acute appendicitis at Kaiser Permanente Fontana Hospital between August 2010 and August 2013...
October 15, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27871090/the-genomic-basis-of-circadian-and-circalunar-timing-adaptations-in-a-midge
#18
Tobias S Kaiser, Birgit Poehn, David Szkiba, Marco Preussner, Fritz J Sedlazeck, Alexander Zrim, Tobias Neumann, Lam-Tung Nguyen, Andrea J Betancourt, Thomas Hummel, Heiko Vogel, Silke Dorner, Florian Heyd, Arndt von Haeseler, Kristin Tessmar-Raible
Organisms use endogenous clocks to anticipate regular environmental cycles, such as days and tides. Natural variants resulting in differently timed behaviour or physiology, known as chronotypes in humans, have not been well characterized at the molecular level. We sequenced the genome of Clunio marinus, a marine midge whose reproduction is timed by circadian and circalunar clocks. Midges from different locations show strain-specific genetic timing adaptations. We examined genetic variation in five C. marinus strains from different locations and mapped quantitative trait loci for circalunar and circadian chronotypes...
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27868317/comparative-testing-of-disinfectant-efficacy-on-planktonic-bacteria-and-bacterial-biofilms-using-a-new-assay-based-upon-kinetic-analysis-of-metabolic-activity
#19
Frank Günther, Martin Scherrer, Stefan J Kaiser, Annalisa DeRosa, Nico T Mutters
AIMS: The aim of our study was to develop a new reproducible method for disinfectant efficacy testing on bacterial biofilms and to evaluate the efficacy of different disinfectants against biofilms. Clinical multidrug-resistant strains were chosen as test isolates to ensure practical relevance. METHODS AND RESULTS: We compared the standard qualitative suspension assay for disinfectant testing, which does not take into account biofilm formation, to the new biofilm viability assay that uses kinetic analysis of metabolic activity in biofilms after disinfectant exposure to evaluate disinfectant efficacy...
November 21, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27865545/anti-cgrp-antibodies-block-cgrp-induced-diarrhea-in-mice
#20
Eric A Kaiser, Brandon J Rea, Adisa Kuburas, Brian R Kovacevich, Leon F Garcia-Martinez, Ana Recober, Andrew F Russo
The multifunctional neuropeptide calcitonin gene-related peptide (CGRP) and its receptor are expressed throughout the gastrointestinal tract. Previous studies have shown that CGRP has roles in intestinal motility, water secretion, and inflammation. Furthermore, animal studies have demonstrated CGRP involvement in diarrhea secondary to C. difficile and food allergies. Diarrhea thus provides a convenient bioassay of CGRP activity in the GI system. In this proof of principle study, we report that prophylactic administration of an anti-CGRP antibody is able to block CGRP-induced diarrhea in mice...
November 14, 2016: Neuropeptides
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