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https://www.readbyqxmd.com/read/29777676/cognitive-effects-of-rhythmic-auditory-stimulation-in-parkinson-s-disease-a-p300-study
#1
Juan Lei, Nadine Conradi, Cornelius Abel, Stefan Frisch, Alla Brodski-Guerniero, Marcel Hildner, Christian A Kell, Jochen Kaiser, Maren Schmidt-Kassow
Rhythmic auditory stimulation (RAS) may compensate dysfunctions of the basal ganglia (BG), involved with intrinsic evaluation of temporal intervals and action initiation or continuation. In the cognitive domain, RAS containing periodically presented tones facilitates young healthy participants' attention allocation to anticipated time points, indicated by better performance and larger P300 amplitudes to periodic compared to random stimuli. Additionally, active auditory-motor synchronization (AMS) leads to a more precise temporal encoding of stimuli via embodied timing encoding than stimulus presentation adapted to the participants' actual movements...
May 16, 2018: Brain Research
https://www.readbyqxmd.com/read/29775390/polarization-and-distribution-of-tumor-associated-macrophages-and-cox-2-expression-in-basal-cell-carcinoma-of-the-ocular-adnexae
#2
Ute Kaiser, Karin U Loeffler, Jennifer Nadal, Frank G Holz, Martina C Herwig-Carl
PURPOSE: Basal cell carcinoma (BCC) is a locally invasive skin tumor which can be subdivided into a circumscribed nodular and an invasive fibrosing subtype. There is increasing evidence that macrophages play an important role in interacting between tumor cells and their microenvironment, thereby affecting not only the invasive potential but also the patients' prognosis. Thus, we wanted to compare these two BCC variants with regard to tumor-related inflammation, COX-2 expression, distribution and polarization of tumor-associated macrophages...
May 18, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29775187/body-mass-index-is-associated-with-all-cause-mortality-after-tha-and-tka
#3
Michelle M Dowsey, Peter F M Choong, Elizabeth W Paxton, Tim Spelman, Robert S Namba, Maria C S Inacio
BACKGROUND: Both obesity and underweight are associated with a higher risk of mortality in adulthood, but the association between mortality after arthroplasty and extreme ranges of body mass index (BMI) have not been evaluated beyond the first year. QUESTIONS/PURPOSES: The purpose of this study was to investigate the association between BMI and all-cause mortality after TKA and THA. METHODS: Data from two arthroplasty registries, the St Vincent's Melbourne Arthroplasty (SMART) Registry from Australia and the Kaiser Permanente Total Joint Replacement Registry (KPTJRR) from the United States, were used to identify patients aged ≥ 18 years undergoing elective TKAs and THAs between January 1, 2002, and December 31, 2013...
June 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29774952/plant-roots-redesign-the-rhizosphere-to-alter-the-three-dimensional-physical-architecture-and-water-dynamics
#4
Sheikh M F Rabbi, Matthew K Tighe, Richard J Flavel, Brent N Kaiser, Chris N Guppy, Xiaoxian Zhang, Iain M Young
The mechanisms controlling the genesis of rhizosheaths are not well understood, despite their importance in controlling the flux of nutrients and water from soil to root. Here, we examine the development of rhizosheaths from drought-tolerant and drought-sensitive chickpea varieties; focusing on the three-dimensional characterization of the pore volume (> 16 μm voxel spatial resolution) obtained from X-ray microtomography, along with the characterization of mucilage and root hairs, and water sorption. We observe that drought-tolerant plants generate a larger diameter root, and a greater and more porous mass of rhizosheath, which also has a significantly increased water sorptivity, as compared with bulk soil...
May 18, 2018: New Phytologist
https://www.readbyqxmd.com/read/29774326/first-identification-of-unstable-phosphino-formic-acid-h-2-pcooh
#5
Cheng Zhu, Robert Frigge, Andrew M Turner, Ralf I Kaiser, Bing-Jian Sun, Si-Ying Chen, Agnes H H Chang
The hitherto elusive phosphino formic acid molecule (H2PCOOH) was detected for the first time in the gas phase. Theoretical calculations revealed an unexpected kinetic stability of H2PCOOH compared to the isovalent carbamic acid (H2NCOOH) although the replacement of a single nitrogen atom by phosphorus decreases the bond order from a partial double (-C[double bond, length as m-dash]N-) to a single (-C-P-) bond. This work provides a fundamental framework to explore the synthesis and stability of derivatives of carbonic acid (H2CO3), in which one or both hydroxyl groups (OH) are replaced by hydride moieties involving third row atoms...
May 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29773712/acute-kidney-injury-and-risk-of-heart-failure-and-atherosclerotic-events
#6
Alan S Go, Chi-Yuan Hsu, Jingrong Yang, Thida C Tan, Sijie Zheng, Juan D Ordonez, Kathleen D Liu
BACKGROUND AND OBJECTIVES: AKI in the hospital is common and is associated with excess mortality. We examined whether AKI is also independently associated with a higher risk of different cardiovascular events in the first year after discharge. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective analysis of a cohort between 2006 and 2013 with follow-up through 2014, within Kaiser Permanente Northern California. We identified all adults admitted to 21 hospitals who had one or more in-hospital serum creatinine test result and survived to discharge...
May 17, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29772218/new-evidence-for-the-benefit-of-psa-screening-data-from-400-887-kaiser-permanente-patients
#7
Paul F Alpert
OBJECTIVES: To investigate whether prostate cancer screening with PSA is beneficial in reducing prostate cancer mortality, and to determine optimal screening intervals and age groups to be screened. MATERIALS AND METHODS: This is a retrospective cohort study of 400,887 men under age 80, with no prior history of prostate cancer, who had PSA testing at Kaiser Permanente Northern California in the 5 calendar years 1998 to 2002, and were followed for 12-16 years. Subjects were stratified into 6 groups based on the screening interval, and into 7 groups based on age...
May 14, 2018: Urology
https://www.readbyqxmd.com/read/29771861/vincristine-associated-neuropathy-with-antifungal-usage-a-kaiser-northern-california-experience
#8
Mina Nikanjam, Aida Sun, Mark Albers, Kristine Mangalindin, Eyun Song, Hyma Vempaty, Danny Sam, Edmund V Capparelli
The dose-limiting toxicity for vincristine is peripheral neuropathy which can be potentiated with concurrent usage of azole antifungals. The current retrospective study assessed the incidence of concurrent vincristine and azole antifungal usage to determine if it led to increased neurotoxicity for the Kaiser Northern California pediatric acute lymphoblastic leukemia (ALL) and Hodgkin lymphoma patient population. Data were obtained from the electronic medical record (2007 to 2014). In total, 130 subjects received at least one dose of vincristine for ALL or Hodgkin lymphoma (median age 9, 88% ALL, 58% male, 47% Caucasian)...
May 16, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29771663/applications-of-deep-learning-and-reinforcement-learning-to-biological-data
#9
Mufti Mahmud, Mohammed Shamim Kaiser, Amir Hussain, Stefano Vassanelli
Rapid advances in hardware-based technologies during the past decades have opened up new possibilities for life scientists to gather multimodal data in various application domains, such as omics, bioimaging, medical imaging, and (brain/body)-machine interfaces. These have generated novel opportunities for development of dedicated data-intensive machine learning techniques. In particular, recent research in deep learning (DL), reinforcement learning (RL), and their combination (deep RL) promise to revolutionize the future of artificial intelligence...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29771582/verification-testing-of-biological-indicators-for-moist-heat-sterilization
#10
Patrick J McCormick, Michael J Schoene, Deanna Pedeville, James J Kaiser, Julie Conyer
No abstract text is available yet for this article.
May 2018: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29771518/a-theoretical-study-of-pyrolysis-of-jp-10-exo-tetrahydrodicyclopentadiene-and-its-primary-and-secondary-unimolecular-decomposition-products
#11
Alexander N Morozov, Alexander Moiseevich Mebel, Ralf I Kaiser
Theoretical calculations of the rate constants and product branching ratios in the pyrolysis of exo-tetrahydrodicyclopentadiene (JP-10) and its initial decomposition products at combustion-relevant pressures and temperatures have been performed and compared to the experimental results from the recently reported molecular beam photoionization mass spectrometry study of the pyrolysis of JP-10 (Zhao, L.; Yang, T.; Kaiser, R. I.; Troy, T. P.; Xu, B.; Ahmed, M.; Alarcon, J.; Belisario-Lara, D.; Mebel, A. M.; Zhang, Y...
May 17, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29770486/direct-estimation-of-17-o-mr-images-diesis-for-quantification-of-oxygen-metabolism-in-the-human-brain-with-partial-volume-correction
#12
Dmitry Kurzhunov, Robert Borowiak, Marco Reisert, Ali Caglar Özen, Michael Bock
PURPOSE: To provide a data post-processing method that corrects for partial volume effects (PVE) and fast T2* decay in dynamic 17 O MRI for the mapping of cerebral metabolic rates of oxygen consumption (CMRO2 ). METHODS: CMRO2 is altered in neurodegenerative diseases and tumors and can be measured after 17 O gas inhalation using dynamic 17 O MRI. CMRO2 quantification is difficult because of PVE. To correct for PVE, a direct estimation of the MR images (DIESIS) method is proposed and used in 4 dynamic 17 O MRI data sets of a healthy volunteer acquired on a 3T MRI system...
May 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29768943/early-reduced-behavioral-activity-induced-by-large-strokes-affects-the-efficiency-of-enriched-environment-in-rats
#13
Anna-Sophia Wahl, Eva Erlebach, Biagio Brattoli, Uta Büchler, Julia Kaiser, Benjamin V Ineichen, Alice C Mosberger, Shirin Schneeberger, Stefan Imobersteg, Martin Wieckhorst, Martina Stirn, Aileen Schroeter, Bjoern Ommer, Martin E Schwab
The majority of stroke patients develop post-stroke fatigue, a symptom which impairs motivation and diminishes the success of rehabilitative interventions. We show that large cortical strokes acutely reduce activity levels in rats for 1-2 weeks as a physiological response paralleled by signs of systemic inflammation. Rats were exposed early (1-2 weeks) or late (3-4 weeks after stroke) to an individually monitored enriched environment to stimulate self-controlled high-intensity sensorimotor training. A group of animals received Anti-Nogo antibodies for the first two weeks after stroke, a neuronal growth promoting immunotherapy already in clinical trials...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29766762/typical-visual-field-locations-enhance-processing-in-object-selective-channels-of-human-occipital-cortex
#14
Daniel Kaiser, Radoslaw M Cichy
Natural environments consist of multiple objects, many of which repeatedly occupy similar locations within a scene. For example, hats are seen on people's heads, while shoes are most often seen close to the ground. Such positional regularities bias the distribution of objects across the visual field: Hats are more often encountered in the upper visual field, while shoes are more often encountered in the lower visual field. Here we test the hypothesis that typical visual-field locations of objects facilitate cortical processing...
May 16, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29766660/the-deterioration-of-muscle-mass-and-radiodensity-is-prognostic-of-poor-survival-in-stage-i-iii-colorectal-cancer-a-population-based-cohort-study-c-scans
#15
Justin C Brown, Bette J Caan, Jeffrey A Meyerhardt, Erin Weltzien, Jingjie Xiao, Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Adrienne Castillo, Marilyn L Kwan, Carla M Prado
BACKGROUND: Muscle abnormalities such as low muscle mass and low muscle radiodensity are well known risk factors for unfavourable cancer prognosis. However, little is known in regard to the degree and impact of longitudinal changes in muscle mass and radiodensity within the context of cancer. Here, we explore the relationship between muscle wasting and mortality in a large population-based study of patients with non-metastatic colorectal cancer (CRC). METHODS: A total of 1924 patients with stage I-III CRC who underwent surgical resection in the Kaiser Permanente Northern California Health System were included...
May 15, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29766408/association-between-circulating-levels-of-heat-shock-protein-27-and-aggressive-periodontitis
#16
Frank Kaiser, Nikos Donos, Brian Henderson, Rajesh Alagarswamy, George Pelekos, David Boniface, Luigi Nibali
Heat-shock protein (Hsp) 27 is a major intracellular molecular chaperone and controller of intracellular responses to inflammatory signals. In the extracellular space, recombinant Hsp27 has been described to exert anti-inflammatory activities. The aim of this study was to assess the association between circulating levels of Hsp27 and different types of periodontitis. Pro- and anti-inflammatory cytokines and the stress proteins Hsp27 and Hsp60 with proposed anti- and pro-inflammatory properties, respectively, were measured by two-site ELISA in the serum of patients with aggressive periodontitis (AgP, n = 30), chronic periodontitis (CP, n = 29) and periodontally healthy controls (H, n = 28)...
May 15, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29765342/mind-control-how-parasites-manipulate-cognitive-functions-in-their-insect-hosts
#17
Frederic Libersat, Maayan Kaiser, Stav Emanuel
Neuro-parasitology is an emerging branch of science that deals with parasites that can control the nervous system of the host. It offers the possibility of discovering how one species (the parasite) modifies a particular neural network, and thus particular behaviors, of another species (the host). Such parasite-host interactions, developed over millions of years of evolution, provide unique tools by which one can determine how neuromodulation up-or-down regulates specific behaviors. In some of the most fascinating manipulations, the parasite taps into the host brain neuronal circuities to manipulate hosts cognitive functions...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29764910/using-quality-improvement-to-tackle-unwarranted-practice-variation
#18
Sunitha V Kaiser, Matthew D Garber
No abstract text is available yet for this article.
May 15, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29764648/rapid-evolution-to-host-plant-resistance-by-an-invasive-herbivore-soybean-aphid-aphis-glycines-virulence-in-north-america-to-aphid-resistant-cultivars
#19
REVIEW
Matthew E O'Neal, Adam J Varenhorst, Matthew C Kaiser
Preventing rapid evolution of herbivores to plant traits that confer resistance is an area of active research for applied entomologists. The subfield of insect resistance management (IRM) uses elements of population genetics and ecology to prevent increases in the frequency of virulent (i.e. resistant) sub-populations of an insect pest. Efforts to delay such an increase include using highly lethal toxins (i.e., a high dose), combining multiple resistance traits in one cultivar (i.e., pyramids), and using susceptible plants (i...
April 2018: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/29763903/central-precocious-puberty-caused-by-a-heterozygous-deletion-in-the-mkrn3-promoter-region
#20
Delanie Macedo, Monica M França, Luciana Montenegro, Marina Cunha-Silva, Danielle S Bessa, Ana Paula Abreu, Ursula B Kaiser, Berenice B Mendonca, Alexander A L Jorge, Vinicius N Brito, Ana C Latronico
<br>Context: Loss-of-function mutations in the coding region of MKRN3, a maternally imprinted gene at chromosome 15q11.2, are a common cause of familial central precocious puberty (CPP). Whether MKRN3 alterations in regulatory regions can cause CPP has not been explored to date. We aimed to investigate potential pathogenic variants in the promoter region of MKRN3 in patients with idiopathic CPP. Patients/ Methods: A cohort of 110 patients with idiopathic CPP was studied. Family history of precocious sexual development was present in 25%...
May 15, 2018: Neuroendocrinology
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