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https://www.readbyqxmd.com/read/28818050/administration-of-two-probiotic-strains-during-early-childhood-does-not-affect-the-endogenous-gut-microbiota-composition-despite-probiotic-proliferation
#1
Martin Frederik Laursen, Rikke Pilmann Laursen, Anni Larnkjær, Kim F Michaelsen, Martin Iain Bahl, Tine Rask Licht
BACKGROUND: Probiotics are increasingly applied to prevent and treat a range of infectious, immune related and gastrointestinal diseases. Despite this, the mechanisms behind the putative effects of probiotics are poorly understood. One of the suggested modes of probiotic action is modulation of the endogenous gut microbiota, however probiotic intervention studies in adults have failed to show significant effects on gut microbiota composition. The gut microbiota of young children is known to be unstable and more responsive to external factors than that of adults...
August 17, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28814317/collaborative-care-for-panic-disorder-generalised-anxiety-disorder-and-social-phobia-in-general-practice-study-protocol-for-three-cluster-randomised-superiority-trials
#2
Nadja Kehler Curth, Ursula Ødum Brinck-Claussen, Annette Sofie Davidsen, Marianne Engelbrecht Lau, Merete Lundsteen, John Hagel Mikkelsen, Claudio Csillag, Carsten Hjorthøj, Merete Nordentoft, Lene Falgaard Eplov
BACKGROUND: People with anxiety disorders represent a significant part of a general practitioner's patient population. However, there are organisational obstacles for optimal treatment, such as a lack of coordination of illness management and limited access to evidence-based treatment such as cognitive behavioral therapy. A limited number of studies suggest that collaborative care has a positive effect on symptoms for people with anxiety disorders. However, most studies are carried out in the USA and none have reported results for social phobia or generalised anxiety disorder separately...
August 16, 2017: Trials
https://www.readbyqxmd.com/read/28811132/relative-changes-in-earned-income-five-years-after-diagnosis-with-diabetes-a-register-based-study-1996-2012
#3
Bryan Cleal, Ulrik Haagen Panton, Ingrid Willaing, Richard I G Holt
OBJECTIVE: With previous studies indicating that diabetes affects employment status and lifetime earnings, the aim of this study was to determine the impact on earnings in the immediate period after diagnosis. Recognising that earnings and employment status are dynamic over the life course, we matched people with diabetes to counterparts in the general population and compared nominal growth in earned income five calendar years after diagnosis. RESEARCH DESIGN AND METHODS: The study draws upon Danish population registers...
July 9, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28803571/a-national-register-based-study-of-paediatric-varicella-hospitalizations-in-denmark-2010-2016
#4
I G Helmuth, A Poulsen, K Mølbak
Varicella, usually a mild disease of childhood, can also cause complications and hospitalization. Universal varicella immunization is implemented in several countries worldwide, but not in Denmark. Taking advantage of unique national registers, we aimed to estimate the incidence of paediatric varicella hospitalizations and assess determinants for hospitalization. For this purpose, we designed a nationwide, retrospective register study of paediatric varicella hospitalizations and applied a case-cohort design and logistic regression analysis comparing hospitalized varicella patients to a sample of the entire paediatric population in Denmark...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28803344/outcome-one-year-after-robot-assisted-rectal-cancer-surgery-a-consecutive-cohort-study
#5
Sanne Harsløf, Anders Stouge, Niels Thomassen, Sissel Ravn, Søren Laurberg, Lene Hjerrild Iversen
PURPOSE: The aim of this study was to investigate outcome after robot-assisted rectal cancer surgery (RARCS). We focused on conversion rate, postoperative complications, pathological evaluation (adequacy of resection margins), and bowel function (low anterior resection syndrome (LARS)) 1 year after surgery. METHODS: An observational study of prospectively registered patients with data obtained from medical records. Data comprise the initial 208 rectal cancer patients operated with robot-assisted surgery at a single Danish university hospital from October 2011 to October 2014...
August 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28803329/childhood-body-mass-index-and-height-in-relation-to-site-specific-risks-of-colorectal-cancers-in-adult-life
#6
Britt W Jensen, Michael Gamborg, Ismail Gögenur, Andrew G Renehan, Thorkild I A Sørensen, Jennifer L Baker
As colorectal cancers have a long latency period, their origins may lie early in life. Therefore childhood body mass index (BMI; kg/m(2)) and height may be associated with adult colorectal cancer. Using a cohort design, 257,623 children from The Copenhagen School Health Records Register born from 1930 to 1972 with measured heights and weights at ages 7 to 13 years were followed for adult colon and rectal adenocarcinomas by linkage to the Danish Cancer Registry. Hazard ratios (HRs) with 95% confidence intervals (CI) were estimated by Cox proportional hazard regressions...
August 12, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28793157/association-of-previous-cesarean-delivery-with-surgical-complications-after-a-hysterectomy-later-in-life
#7
Sofie A I Lindquist, Neel Shah, Charlotte Overgaard, Christian Torp-Pedersen, Karin Glavind, Thomas Larsen, Avery Plough, Grace Galvin, Aage Knudsen
Importance: In recent decades, the global rates of cesarean delivery have rapidly increased. Nonetheless, the influence of cesarean deliveries on surgical complications later in life has been understudied. Objective: To investigate whether previous cesarean delivery increases the risk of reoperation, perioperative and postoperative complications, and blood transfusion when undergoing a hysterectomy later in life. Design, Setting, and Participants: This registry-based cohort study used data from Danish nationwide registers on all women who gave birth for the first time between January 1, 1993, and December 31, 2012, and underwent a benign, nongravid hysterectomy between January 1, 1996, and December 31, 2012...
August 9, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28791695/use-of-antidepressants-and-risk-of-epithelial-ovarian-cancer
#8
Lina S Mørch, Christian Dehlendorff, Louise Baandrup, Søren Friis, Susanne K Kjaer
Antidepressants are widely prescribed among women to treat depression and anxiety disorders, but studies of their effects on gynecological cancer risk are sparse. We assessed associations between various antidepressants and risk of epithelial ovarian cancer. By using Danish nationwide registers, we identified all women (cases) aged 30 to 84 years with incident epithelial (serous, endometrioid, clear cell or mucinous) ovarian cancer during 2000-2011 (n= 4,103) and matched each case to 20 population controls (n=58,706) by risk-set matching...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28783203/cumulative-occupational-mechanical-exposures-during-working-life-and-risk-of-sickness-absence-and-disability-pension-prospective-cohort-study
#9
Emil Sundstrup, Åse Marie Hansen, Erik Lykke Mortensen, Otto Melchior Poulsen, Thomas Clausen, Reiner Rugulies, Anne Møller, Lars L Andersen
Objectives The aim of this study was to determine the prospective association of cumulative mechanical exposure during working life with health-related labor market outcomes. Methods This prospective cohort study combines data from 5076 older workers (age 49-63 years) from the Copenhagen Aging and Midlife Biobank with a job exposure matrix and a national register containing information on social transfer payment. By coding individual job histories from the Danish version of ISCO-codes (International Standard Classification of Occupations), we calculated cumulative occupational mechanical exposures from a JEM for ton-years (lifting 1000 kg each day in one year), lifting-years (lifting loads weighing ≥20 kg >10 times each day in one year), kneeling-years (kneeling for one hour each day in one year) and vibration-years (whole-body vibration for one hour each day in one year)...
August 7, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28782868/klinefelter-s-syndrome-and-sexual-offending-a-literature-review
#10
Rebecca O'Donovan, Birgit Völlm
BACKGROUND: Klinefelter's syndrome is a sex chromosome abnormality affecting approximately 1 in 1000 men. There have been suggestions that it is associated with a higher than average prevalence of sexual offending but to what extent does research evidence support this assertion? AIMS: This study aimed to conduct a systematic review of published research to establish the prevalence of sexual offending in men with Klinefelter's syndrome. METHOD: The databases MEDLINE, PsycINFO and EMBASE were searched from inception until 31 December 2016 by using a range of terms for Klinefelter's syndrome and for sexual offending...
August 7, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/28782800/breast-cancer-recurrence-after-reoperation-for-surgical-bleeding
#11
R N Pedersen, K Bhaskaran, U Heide-Jørgensen, M Nørgaard, P M Christiansen, N Kroman, H T Sørensen, D P Cronin-Fenton
BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence. METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified...
August 7, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28782109/low-vs-high-haemoglobin-trigger-for-transfusion-in-vascular-surgery-protocol-for-a-randomised-trial
#12
A Møller, H B Nielsen, J Wetterslev, O B Pedersen, D Hellemann, S Shahidi
BACKGROUND: In patients with cardiovascular disease, guidelines for administration of red blood cells (RBC) are mainly based on studies outside the vascular surgical setting with the recommendation to use a haemoglobin (hb) trigger-level lower than by guidelines from The European Society for Vascular Surgery. Restricting RBC transfusion may affect blood O2 transport with a risk for development of tissue ischaemia and postoperative complications. METHODS: In a single-centre, open-label, assessor blinded trial, 58 vascular surgical patients (> 40 years of age) awaiting open surgery of the infrarenal aorta or infrainguinal arterial bypass surgery undergo a web-based randomisation to one of two groups: perioperative RBC transfusion triggered by hb < 8 g/dl or hb < 9...
September 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28772007/the-impact-of-comorbidities-on-tumor-necrosis-factor-inhibitor-therapy-in-psoriatic-arthritis-a-population-based-cohort-study
#13
Christine Ballegaard, Pil Højgaard, Lene Dreyer, René Cordtz, Tanja Schjødt Jørgensen, Marie Skougaard, Simon Tarp, Lars Erik Kristensen
OBJECTIVE: The objective of this population-based cohort study was to investigate the impact of comorbidities on disease activity, treatment response and persistence with the first-tried tumor necrosis factor inhibitor (TNFi) in patients with psoriatic arthritis (PsA). METHODS: Data on patient characteristics, disease activity and treatment response and persistence was obtained from the DANBIO registry. Information on comorbidities according to the Charlson Comorbidity Index (CCI) was obtained through linkage with the Danish National Patient Register...
August 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28766013/metal-arc-welding-and-the-risk-of-skin-cancer
#14
K N Heltoft, R M Slagor, T Agner, J P Bonde
OBJECTIVES: Arc welding produces the full spectrum of ultraviolet radiation and may be a contributory cause of skin cancer; however, there has been little research into this occupational hazard. The aim of this study is to explore if metal arc welding increases the risk of malignant melanoma and/or basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) on skin areas which may possibly be exposed (neck, head, and upper extremities). METHOD: A Danish national company-based historic cohort of 4333 male metal arc welders was followed from 1987 through 2012 to identify the risk of skin cancer...
August 1, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28761652/incidence-of-severe-hypoglycemia-in-children-with-type-1-diabetes-in-the-nordic-countries-in-the-period-2008-2012-association-with-hemoglobin-a-1c-and-treatment-modality
#15
N H Birkebaek, A K Drivvoll, K Aakeson, R Bjarnason, A Johansen, U Samuelsson, T Skrivarhaug, A V Thorsson, J Svensson
OBJECTIVE: Treatment of type 1 diabetes has been intensified aiming at normalizing blood glucose, which may increase the risk of severe hypoglycemia (SH). We aimed to compare the incidence of SH events in the four Nordic countries Denmark, Iceland, Norway and Sweden, and to assess the influence of hemoglobin A1c (HbA1c) and treatment modalities on the frequency of SH; particularly, to explore if a HbA1c target ≤6.7% (50 mmol/mol) is feasible. RESEARCH DESIGN AND METHODS: Data on children below 15 years with a diabetes duration more than 1 year, registered in the national childhood diabetes databases in the four Nordic countries from 2008 to 2012, were compiled...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28755788/concordance-of-autoimmune-disease-in-a-nationwide-danish-systemic-lupus-erythematosus-twin-cohort
#16
Constance Jensina Ulff-Møller, Anders Jørgen Svendsen, Louise Nørgaard Viemose, Søren Jacobsen
OBJECTIVE: To determine the concordance of systemic lupus erythematosus (SLE) and co-aggregating autoimmune diseases among Danish twins. METHODS: SLE-affected twins were ascertained by record linkage between the National Patient Register (NPR) and the Danish Twin Registry (DTR). Registered SLE codes were validated through medical chart review and information from the treating physicians. Twin pairs with at least one chart-validated SLE proband were invited to participate in a personal interview and clinical validation of the SLE diagnoses...
June 23, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28750620/efficacy-of-commercialised-extracorporeal-shock-wave-lithotripsy-service-a-review-of-589-renal-stones
#17
Tommy Kjærgaard Nielsen, Jørgen Bjerggaard Jensen
BACKGROUND: Extracorporeal shockwave lithotripsy (ESWL) is the management of choice for renal stones 20 mm or smaller, with a stone clearance rate of up to 89%. The purpose of the present is to investigate the efficacy of a commercialised ESWL service, being performed as an outsourced treatment using a mobile lithotripsy system on an outpatient basis. Furthermore, the study aims to evaluate the risk of needing treatment with an internal ureteral double-J stent (JJ) after ESWL treatment...
July 27, 2017: BMC Urology
https://www.readbyqxmd.com/read/28748324/alcohol-drinking-patterns-and-risk-of-diabetes-a-cohort-study-of-70-551-men-and-women-from-the-general-danish-population
#18
Charlotte Holst, Ulrik Becker, Marit E Jørgensen, Morten Grønbæk, Janne S Tolstrup
AIMS/HYPOTHESIS: Alcohol consumption is inversely associated with diabetes, but little is known about the role of drinking patterns. We examined the association between alcohol drinking patterns and diabetes risk in men and women from the general Danish population. METHODS: This cohort study was based on data from the Danish Health Examination Survey 2007-2008. Of the 76,484 survey participants, 28,704 men and 41,847 women were eligible for this study. Participants were followed for a median of 4...
July 27, 2017: Diabetologia
https://www.readbyqxmd.com/read/28741399/incidence-of-pancreatic-cancer-in-denmark-70-years-of-registration-1943-2012
#19
Tanja Cruusberg Weble, Jon Kroll Bjerregaard, Peter Kissmeyer, Mogens Vyberg, Carsten Palnaes Hansen, Niels Henrik Holländer, Christoffer Johansen
BACKGROUND: The aim of this study was to monitor the evolution of the incidence of pancreatic cancer in Denmark over 70 years. We also compared registrations of pancreatic cancer in a nationwide population-based database, the Danish Cancer Registry, and a clinical database, the Danish Pancreatic Cancer Database, in 2012-2013. MATERIAL AND METHODS: Registrations of pancreatic cancer from the Danish Cancer Registry over 1943-2012 were used to calculate age-specific incidence rates per 100 000 person years by sex and age in 5-year period, weighted by the Segi World Standard Population for age standardization...
July 25, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28736760/self-harm-and-violent-criminality-among-young-people-who-experienced-trauma-related-hospital-admission-during-childhood-a-danish-national-cohort-study
#20
Roger T Webb, Sussie Antonsen, Matthew J Carr, Louis Appleby, Carsten B Pedersen, Pearl L H Mok
BACKGROUND: Development of a better understanding of subsequent pathways for individuals who experienced trauma during childhood might usefully inform clinicians and public health professionals regarding the causes of self-harm and interpersonal violence. We aimed to examine these risks during late adolescence and early adulthood among people admitted to hospital following injuries or poisonings during their childhood. METHODS: This national cohort study included Danish people born between Jan 1, 1977, and Dec 31, 1997, and was linked to the National Patient Register and Psychiatric Central Research Register to identify all people exposed to hospital admissions for injuries or poisonings due to self-harm, interpersonal violence, or accidents before their 15th birthday...
July 2017: Lancet. Public Health
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