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Danish register

Rikke Wiingreen, Gorm Greisen, Jannet Svensson, Bo Mølholm Hansen
OBJECTIVES: Several studies suggest a relationship between gestational age at birth and risk of school difficulties. Our study aimed to investigate the association between the entire range of gestational ages and significant school difficulties measured as 1) More than nine hours per week special educational support and 2) Failing to complete compulsory school. METHODS: A population-based register study including all children attending the Danish compulsory school in 2015/2016 and all live-born infants born in Denmark from 1992 to 1997...
2018: PloS One
Janni Katharina Stuhr, Jesper Lykkegaard, Jette Kolding Kristensen, Jette Brommann Kornum, Malene Plejdrup Hansen
Background: Sore throat is a frequent presentation of acute respiratory tract infections in general practice. Though these infections are often harmless and self-limiting, antibiotics are frequently prescribed. In Denmark, practice nurses manage an increasing part of patients with acute minor illnesses. Objectives: We aimed (i) to investigate Danish practice nurses' and GPs' management of patients presenting with a sore throat and (ii) to explore to what extent management is according to current Danish guidelines...
June 19, 2018: Family Practice
Line Pickering, Poul Jennum, Rikke Ibsen, Jakob Kjellberg
We estimated the long-term socioeconomic consequences and health care costs of Neisseria meningitidis meningitis (NM). The prospective cohort study included Danish individuals with onset of NM in childhood and adolescence, diagnosed between 1980 and 2009. Health care costs and socioeconomic data were obtained from nationwide administrative and health registers. Two thousand nine hundred two patients were compared with 11,610 controls matched for age, gender, and other sociodemographic characteristics. In the follow-up analysis at the age of 30 years, 1028 patients were compared with 4452 controls...
June 20, 2018: European Journal of Pediatrics
Christine F Klein, Sanne Gørtz, Jan Wohlfahrt, Tina N Munch, Mads Melbye, Henning Bundgaard, Kasper K Iversen
Background: The present study aimed to investigate the long-term risk of hemorrhagic stroke (HS) in patients with infective endocarditis (IE). Methods: Using a register-based nationwide cohort of 9 million Danes, we propensity score-matched patients with left-sided IE from 1977 to mid-2015 with IE-free individuals (1:10). Follow up started one year after the IE diagnosis. Hazard ratios (HRs) for HS in IE patients compared to the matched cohort were estimated using Cox regression...
June 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Hanne Hauger, Christian Mølgaard, Charlotte Mortensen, Christian Ritz, Hanne Frøkiær, Taryn J Smith, Kathryn Hart, Susan A Lanham-New, Camilla T Damsgaard
Background: Low serum 25-hydroxyvitamin D [25(OH)D] has been associated with unfavorable cardiometabolic risk profiles in many observational studies in children, but very few randomized controlled trials have investigated this. Objective: We explored the effect of winter-time cholecalciferol (vitamin D3) supplementation on cardiometabolic risk markers in young, white, 4- to 8-y-old healthy Danish children (55°N) as part of the pan-European ODIN project. Methods: In the ODIN Junior double-blind, placebo-controlled, dose-response trial, 119 children (mean ± SD age: 6...
June 15, 2018: Journal of Nutrition
Jindong Ding Petersen, Volkert Dirk Siersma, René Depont Christensen, Maria Munch Storsveen, Connie Thurøe Nielsen, Mikkel Vass, Frans Boch Waldorff
AIM: We used register-based data to estimate the effect of all-type dementia on road traffic accidents (RTAs) risk, combined with comorbidities or sedative medicines, among non-institutionalized older people in Denmark. METHODS: The source population was all residents in Denmark aged 65 years and older, alive as of January 1, 2008 ( n = 853,228). Cases were those who had any type of RTA in 2009-2014. Each case was matched for age, sex and geographic location to 4-6 controls...
June 1, 2018: Scandinavian Journal of Public Health
L Grode, B H Bech, O Plana-Ripoll, M Bliddal, I E Agerholm, P Humaidan, C H Ramlau-Hansen
STUDY QUESTION: How does celiac disease (CD) influence women's reproductive life, both prior to and after the diagnosis? SUMMARY ANSWER: Prior to the diagnosis of CD, an increased risk of adverse pregnancy outcomes was seen, whereas after the diagnosis, no influence on reproductive outcomes was found. WHAT IS KNOWN ALREADY: CD has been associated with several conditions influencing female reproduction and pregnancy outcomes including spontaneous abortion and stillbirth...
June 15, 2018: Human Reproduction
Pearl L H Mok, Aske Astrup, Matthew J Carr, Sussie Antonsen, Roger T Webb, Carsten B Pedersen
INTRODUCTION: Separation from a parent during childhood has been linked with heightened longer-term violence risk, but it remains unclear how this relationship varies by gender, separation subgroup, and age at separation. This phenomenon was investigated by examining a wide array of child-parent separation scenarios. METHODS: National cohort study including individuals born in Denmark, 1971-1997 (N=1,346,772). Child-parent separation status was ascertained each year from birth to 15th birthday, using residential addresses from the Danish register...
June 14, 2018: American Journal of Preventive Medicine
Harald Hannerz, Ann Dyreborg Larsen, Anne Helene Garde
OBJECTIVES: The aim of the present study was to test if incidences of ischaemic heart disease (IHD) and usage of antihypertensive drugs are independent of weekly working hours (WWH) among full-time employees in Denmark. DESIGN AND PARTICIPANTS: Data on WWH from participants of the Danish labour force surveys, 1999-2013, were linked on an individual level to national registers with data on socioeconomic status (SES), industry, emigrations, redeemed prescriptions, hospital contacts and deaths...
June 15, 2018: BMJ Open
Lea L B Lauridsen, Linn H Arendt, Andreas Ernst, Nis Brix, Erik T Parner, Jørn Olsen, Cecilia H Ramlau-Hansen
OBJECTIVE: To study the association between maternal diabetes and timing of pubertal development in daughters and sons. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 15,822 mother-child pairs included in the Danish National Birth Cohort and the Puberty Cohort with prospectively collected, register-based and self-reported information on maternal diabetes and self-reported information on pubertal development...
June 13, 2018: Fertility and Sterility
Line Schmidt, Stina Öberg, Kristoffer Andresen, Jacob Rosenberg
BACKGROUND: Few studies have described recurrence rates after groin hernia repair in women. Our aim was to investigate if laparoscopic repair of primary groin hernias in women results in a lower reoperation rate for recurrence compared with open repairs. Furthermore, we wished to compare hernia subtypes at primary repair and reoperation. METHODS: This nationwide cohort study was reported according to the RECORD statement. We used prospectively collected data from the Danish Hernia Database to generate a cohort of females operated for a primary groin hernia from 1998 to 2017...
June 15, 2018: Surgical Endoscopy
Susanne Oksbjerg Dalton, Nis Palm Suppli, Marianne Ewertz, Niels Kroman, Luigi Grassi, Christoffer Johansen
OBJECTIVES: To investigate overall and breast cancer-specific mortality in early-stage breast cancer patients with and without schizophrenia or related disorders. METHODS: We used Danish national registers to identify all women with no prior history of cancer or organic mental disorders, who were diagnosed with early-stage breast cancer 1995-2011. Logistic regression models were used to calculate the odds ratios (ORs) for not being allocated to guideline treatment...
June 11, 2018: Breast: Official Journal of the European Society of Mastology
Karina Hjort-Pedersen, Annette Wind Olesen, Ester Garne, Lene Sperling
BACKGROUND: The aim of the study was to estimate the proportion of women giving birth in two hospitals in the Region of Southern Denmark who did not attend the malformation scan and to elucidate the reasons for not participating. METHODS: In this register-based descriptive study, we used patient administration systems to identify women who had given birth at two Danish hospitals between March 2013 and January 2015. We then linked this information with the hospital database for fetal medicine (Astraia) to identify women who did not attend the malformation scan at week 18-20...
June 14, 2018: BMC Pregnancy and Childbirth
Mette Rasmussen, Mads Klinge, Jesper Krogh, Merete Nordentoft, Hanne Tønnesen
OBJECTIVES: We compared the effectiveness of an intensive smoking cessation intervention among smokers with and without a severe mental disorder (SMD) and identified factors associated with successful quitting. The main hypothesis was that smokers with an SMD would be less likely to stay continuously smoke-free for 6 months. DESIGN: A prospective cohort study. SETTING: In all, 302 smoking cessation clinics in Denmark from municipal clinics, pharmacies, hospitals, midwives, primary care facilities and other private providers who reported data to the national Danish Smoking Cessation Database from 2006 to 2016 participated in this study...
June 11, 2018: BMJ Open
Pil Højgaard, Christine Ballegaard, René Cordtz, Kristian Zobbe, Marianne Clausen, Bente Glintborg, Lars Erik Kristensen, Lene Dreyer
Objective: We aimed to investigate gender differences in disease manifestations, patient-reported outcomes, comorbidities and treatment effectiveness among patients with PsA treated with their first TNFα inhibitor (TNFI). Methods: In this observational cohort study, the DANBIO register provided prospectively collected data on PsA patients who initiated their first TNFI in 2000-15. Comorbidity information was achieved from the Danish Nationwide Patient Register...
June 9, 2018: Rheumatology
A Toender, T Munk-Olsen, M Vestergaard, J T Larsen, N P Suppli, S O Dalton, P Vedsted, M Nordentoft, P B Mortensen, T M Laursen
BACKGROUND: Excess mortality in individuals with severe mental illness (SMI) is often explained by physical comorbidity and suboptimal healthcare. Cancer is a prevalent cause of death, and tumour stage at diagnosis is a strong predictor of mortality. We aimed to study cancer incidence, disease stage at diagnosis and subsequent mortality in individuals with SMI compared to individuals without SMI. METHODS: The entire Danish population was followed in 1978-2013 using nationwide registries...
June 8, 2018: Schizophrenia Research
Christian Sørensen Bork, Stine Krogh Venø, Søren Lundbye-Christensen, Marianne Uhre Jakobsen, Anne Tjønneland, Philip C Calder, Kim Overvad, Erik Berg Schmidt
BACKGROUND: The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) may reduce the risk of cardiovascular disease. OBJECTIVE: We have investigated associations between the content of ALA in adipose tissue and the risk of ischemic stroke and its subtypes. METHODS: Incident cases of ischemic stroke among participants enrolled into the Danish Diet, Cancer and Health cohort (n = 57,053) were identified by linkage with the Danish National Patient Register...
2018: PloS One
Line Olsen, Thomas Sparsø, Shantel M Weinsheimer, Marcelo Bertalan Quintanilha Dos Santos, Wiktor Mazin, Anders Rosengren, Xabier Calle Sanchez, Louise K Hoeffding, Henriette Schmock, Marie Baekvad-Hansen, Jonas Bybjerg-Grauholm, Mark J Daly, Benjamin M Neale, Marianne G Pedersen, Esben Agerbo, Ole Mors, Anders Børglum, Merete Nordentoft, David M Hougaard, Preben Bo Mortensen, Daniel H Geschwind, Carsten Pedersen, Wesley K Thompson, Thomas Werge
BACKGROUND: Although the pathogenic nature of copy number variants (CNVs) on chromosome 22q11.2 has been recognised for decades, unbiased estimates of their population prevalence, mortality, disease risks, and diagnostic trajectories are absent. We aimed to provide the true population prevalence of 22q11.2 CNVs and associated trajectory of disease risk and mortality by use of the unbiased, representative Danish iPSYCH population case cohort. METHODS: This case-cohort study was done on a population of 86 189 individuals selected from the iPSYCH case cohort of 1 472 762 singletons born in Denmark between May 1, 1981, and Dec 31, 2005, who have a known mother from the Danish Civil Registration System, were residents in Denmark at 1 year of age, and enrolled in the iPSYCH Initiative...
June 6, 2018: Lancet Psychiatry
J H Hesselvig, A Egeberg, K Kofoed, G Gislason, L Dreyer
BACKGROUND: Reported prevalences of depression in patients with systemic lupus erythematosus (SLE) range widely, while the prevalence of depression in cutaneous lupus erythematosus (CLE) remains severely understudied. OBJECTIVES: To examine whether patients with SLE or CLE have increased risk of depression. METHODS: In this nationwide observational cohort study, we included patients ≥ 18 years with a first-time diagnosis of SLE or CLE between 2000-2015 identified in the Danish National Patient Register matched with general population in a 1:10 ratio...
June 9, 2018: British Journal of Dermatology
Lars Morso, Berit Schiøttz-Christensen, Jens Søndergaard, Nils-Bo de Vos Andersen, Flemming Pedersen, Kim Rose Olsen, Morten Sall Jensen, Jonathan Hill, David Høyrup Christiansen
BACKGROUND: Prior studies indicate that stratified care for low back pain results in better clinical outcome and reduced costs in healthcare compared to current practice. Stratified care may be associated with clinical benefits for patients with low back pain at a lower cost, but evidence is sparse. Hence this study aims to evaluate the clinical effects and cost-effectiveness of stratified care in patients with non-specific low back pain compared to current practice. METHODS/DESIGN: The study is a two-armed randomised controlled trial in primary care in the Regions of Southern and Central Denmark (2...
June 8, 2018: Trials
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