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https://www.readbyqxmd.com/read/29684191/importance-of-beta-blocker-dose-in-prevention-of-ventricular-tachyarrhythmias-heart-failure-hospitalizations-and-death-in-primary-prevention-implantable-cardioverter-defibrillator-recipients-a-danish-nationwide-cohort-study
#1
A C Ruwald, G H Gislason, M Vinther, J B Johansen, J C Nielsen, B T Philbert, C Torp-Pedersen, S Riahi, C Jøns
Aims: There is a paucity of studies investigating a dose-dependent association between beta-blocker therapy and risk of outcome. In a nationwide cohort of primary prevention implantable cardioverter-defibrillator (ICD) patients, we aimed to investigate the dose-dependent association between beta-blocker therapy and risk of ventricular tachyarrhythmias (VT/VF), heart failure (HF) hospitalizations, and death. Methods and results: Information on ICD implantation, endpoints, comorbidities, beta-blocker usage, type, and dose were obtained through Danish nationwide registers...
April 19, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29673038/pelvic-insufficiency-fractures-frequently-occur-following-preoperative-chemo-radiotherapy-for-rectal-cancer-a-nationwide-mri-study
#2
Jesper Beck Jørgensen, Peter Bondeven, Lene Hjerrild Iversen, Søren Laurberg, Bodil Ginnerup Pedersen
AIM: The aim of this prospective case-control study was to evaluate the rate of pelvic insufficiency fractures (PIF) in Denmark using magnetic resonance imaging (MRI) at 3-year follow-up. All patients had rectal cancer and had undergone surgery with or without preoperative chemo-radiotherapy (CRT). METHOD: Patients registered with primary rectal cancer in the Danish Colorectal Cancer Group database, who underwent rectal cancer resection from April 2011 through August 2012, were invited to participate in a national MRI study aiming to detect local recurrence and evaluate quality of the surgical treatment...
April 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29669140/night-work-and-hypertensive-disorders-of-pregnancy-a-national-register-based-cohort-study
#3
Paula Hammer, Esben Flachs, Ina Specht, Anja Pinborg, Sesilje Petersen, Ann Larsen, Karin Hougaard, Johnni Hansen, Åse Hansen, Henrik Kolstad, Anne Garde, Jens Peter Bonde
Objective The aim of this study was to investigate whether night work expressed by number and duration of night shifts, number of consecutive night shifts, and number of quick returns during the first 20 weeks of pregnancy is a risk factor for hypertensive disorders of pregnancy (HDP). Methods The study population comprised Danish workers in public administration and hospitals who gave birth between 2007 and 2013. Exposure was assessed objectively through payroll data. Information on the outcome was retrieved from the National Patient Register...
April 18, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29667167/out-of-home-placement-to-age-18-years-in-children-exposed-to-a-postpartum-mental-disorder
#4
Simone N Vigod, Thomas Munk Laursen, Anne Ranning, Merete Nordentoft, Trine Munk-Olsen
OBJECTIVES: Little is known about risk of custody loss or out-of-home placement among children whose mothers experience postpartum mental disorders, and whether this risk differs from that of children whose mothers had earlier onset of their mental disorder. METHODS: National Danish registers comprising 1 868 467 births (1982-2012) were used to determine how the timing of maternal illness onset influences out-of-home placement risk up to age 18 years among children exposed to a maternal mental disorder...
April 17, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29664236/use-of-non-vitamin-k-antagonist-oral-anticoagulants-2008-2016-a-danish-nationwide-cohort-study
#5
Simone Haastrup, Maja Hellfritzsch, Lotte Rasmussen, Anton Pottegård, Erik Lerkevang Grove
We aimed to provide detailed utilization data on the total use of non-vitamin K antagonist oral anticoagulants (NOACs) since their introduction in 2008. Using the nationwide Danish National Prescription Registry, we identified all individuals filling prescriptions for NOACs 2008-2016. We reported the development in incident and prevalent users and explored baseline characteristics and treatment persistence according to treatment indication. A total of 126,691 NOAC users were identified within the Danish population of 5...
April 17, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29664233/positive-predictive-value-of-a-register-based-algorithm-using-the-danish-national-registries-to-identify-suicidal-events
#6
Christiane Gasse, Andreas Aalkjaer Danielsen, Marianne Giørtz Pedersen, Carsten Bøcker Pedersen, Ole Mors, Jakob Christensen
PURPOSE: It is not possible to fully assess intention of self-harm and suicidal events using information from administrative databases. We conducted a validation study of intention of suicide attempts/self-harm contacts identified by a commonly applied Danish register-based algorithm (DK-algorithm) based on hospital discharge diagnosis and emergency room contacts. METHODS: Of all 101 530 people identified with an incident suicide attempt/self-harm contact at Danish hospitals between 1995 and 2012 using the DK-algorithm, we selected a random sample of 475 people...
April 17, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29659206/effects-of-antipsychotics-on-secular-mortality-trends-in-patients-with-alzheimer-s-disease
#7
René Ernst Nielsen, Jan B Valentin, Annette Lolk, Kjeld Andersen
OBJECTIVE: To investigate secular changes in mortality rates between patients with Alzheimer's disease (AD) and the general population as well as changes in antipsychotic drug treatment and the association between drug treatment and mortality in patients with AD in Denmark during a 12-year study period. METHODS: This nationwide, retrospective cohort study identified all-cause mortality in all Danish patients with incident ICD-10-defined AD from 2000 through 2011...
April 3, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29656261/young-adult-cognitive-ability-and-subsequent-major-depression-in-a-cohort-of-666-804-danish-men
#8
Gunhild Tidemann Christensen, Maarten Pieter Rozing, Erik Lykke Mortensen, Kaare Christensen, Merete Osler
BACKGROUND: Early life cognitive ability (CA) might influence the risk of developing major depression (MD). The aim was to investigate the association between young adult CA and subsequent MD in relation to different MD disease characteristics. METHODS: Information on CA was assessed at conscription board examinations 1957-1984 (mean age 19 years) and information on MD was based on hospital diagnosis retrieved from Danish Patient registers 1969-2015. Associations between CA and MD were examined using Cox regression analyses...
April 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29652735/nursing-sensitive-outcomes-after-severe-traumatic-brain-injury-a-nationwide-study
#9
Lene Odgaard, Lena Aadal, Marianne Eskildsen, Ingrid Poulsen
BACKGROUND: Complications such as infections and conditions after immobilization are frequent after severe traumatic brain injury (TBI) due to compromised bodily functions. Traditionally, bodily functions are core elements in nursing, and therefore nurses in the rehabilitation departments are pivotal in the prevention of complications. Hence, the frequency of complications is an indicator of nursing care quality, which can be included in nursing-sensitive outcome indicators. To do so, it is necessary to know the frequency of the selected complications...
April 12, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29642552/three-dimensional-registration-for-handheld-profiling-systems-based-on-multiple-shot-structured-light
#10
Shirazi Muhammad Ayaz, Danish Khan, Min Young Kim
In this article, a multi-view registration approach for the 3D handheld profiling system based on the multiple shot structured light technique is proposed. The multi-view registration approach is categorized into coarse registration and point cloud refinement using the iterative closest point (ICP) algorithm. Coarse registration of multiple point clouds was performed using relative orientation and translation parameters estimated via homography-based visual navigation. The proposed system was evaluated using an artificial human skull and a paper box object...
April 9, 2018: Sensors
https://www.readbyqxmd.com/read/29626451/effectiveness-of-colorectal-cancer-screening-in-detecting-earlier-stage-disease-a-nationwide-cohort-study-in-denmark
#11
Mette Bach Larsen, Sisse Njor, Peter Ingeholm, Berit Andersen
BACKGROUND & AIMS: Most studies of the effectiveness of screening for colorectal cancer (CRC) using the fecal occult blood test (FOBT) tested the guaiac FOBT. However, the fecal immunochemical test (FIT) is now commonly used in screening. We aimed to evaluate the effects of FIT-based screening for CRC on the number of incident CRC diagnoses and stage at diagnosis for individuals in Denmark who were invited for screening vs not invited. METHODS: We collected data from a register-based retrospective cohort study during the first 16 months of the prevalence round of a FIT-based CRC screening program (March 1, 2014 through June 30, 2015)...
April 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29625579/is-treatment-outcome-improved-if-patients-match-themselves-to-treatment-options-study-protocol-for-a-randomized-controlled-trial
#12
Morten Ellegaard Hell, William R Miller, Bent Nielsen, Anette Søgaard Nielsen
BACKGROUND: Research on matching patients to treatment has shown that matching grounded in expert views is little better than allocating patients by chance. Furthermore, there is growing emphasis on involving patients in their own treatment as a key to health behavior change. Research on the benefit of having patients choose their treatment from among options, in contrast to being assigned to a treatment by experts, has been limited. Consequently, we designed a rigorous test of patient self-matching to determine whether it does improve retention, adherence, and outcome in alcoholism treatment...
April 6, 2018: Trials
https://www.readbyqxmd.com/read/29619932/mortality-and-morbidity-in-patients-with-osteogenesis-imperfecta-in-denmark
#13
Lars Folkestad
Ostegenesis imperfecta (OI) is a hereditary disease of the connective tissue caused by mutations to, mainly, the genes that are involved in the biosynthesis of collagen type 1. Patients are grouped according to clinical severity and mode of inheritance according to Sillence's classification (originally 1979, updated 2014). According to our data, the population prevalence of OI in Denmark was 10.3 per 100,000, with 575 patients registered with an OI diagnosis in the National Patient Register and alive at the end of 2012 out of a total population of 5,602,628 persons...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619927/joinpoint-regression-analysis-of-suicides-in-denmark-during-1980-2015
#14
Susanne Mahmood Dyvesether, Merete Nordentoft, Julie Lyng Forman, Annette Erlangsen
INTRODUCTION: Major advances have been achieved in suicide prevention over the past decades. Effective suicide prevention requires vigilant monitoring of suicide trends. The aim of this study was to assess the change in the Danish suicide rate over time using joinpoint regression analysis and to examine the distribution of suicide methods in the 1980-2015 period. METHODS: Nationwide register data were obtained from the Central Research Register and the Danish Cause of Death Register...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619925/the-validity-of-the-diagnosis-of-heart-failure-i50-0-i50-9-in-the-danish-national-patient-register
#15
Joanna Delekta, Steen Møller Hansen, Karam Sadoon AlZuhairi, Christian Sørensen Bork, Albert Marni Joensen
INTRODUCTION: National discharge registers are important and cost-effective data sources for administrative and research purposes, but their value depends much on the validity of the registered data. The objective of this study was to assess the validity of heart failure (HF) diagnoses (ICD10: I50.0-I50.9) in the Danish National Patient Register (DNPR). METHODS: We reviewed medical records from a random sample of 500 patients with either a primary or a secondary discharge diagnosis of HF registered in the DNPR from any department in Northern Denmark in 2007...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619634/add-on-treatment-with-n-acetylcysteine-for-bipolar-depression-a-24-week-randomized-double-blind-parallel-group-placebo-controlled-multicentre-trial-nacos-study-protocol
#16
Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi, Connie Thuroee Nielsen
BACKGROUND: Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depressive episodes, especially compared with the efficacy of treatment for acute mania. N-Acetylcysteine (NAC) has been explored for psychiatric disorders for some time given its antioxidant and anti-inflammatory properties. The current trial aims at testing the clinical effects of adjunctive NAC treatment (compared to placebo) for bipolar depression...
April 5, 2018: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29616288/organ-support-therapy-in-the-intensive-care-unit-and-return-to-work-a-nationwide-register-based-cohort-study
#17
Signe Riddersholm, Steffen Christensen, Kristian Kragholm, Christian F Christiansen, Bodil Steen Rasmussen
PURPOSE: The association between severity of illness and ability to return to work is unclear. Therefore, we investigated return to work and associations with measures of illness severity in ICU survivors. METHODS: We conducted this cohort study using Danish registry data for the period 2005-2014 on ICU patients who were discharged alive from hospital, had an ICU length of stay (LOS) of at least 72 h, were not treated with dialysis before hospital admission and were working prior to admission...
April 3, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29609630/rationale-and-design-for-cognitive-behavioral-therapy-for-anxiety-disorders-in-children-with-autism-spectrum-disorder-a-study-protocol-of-a-randomized-controlled-trial
#18
Tina R Kilburn, Merete Juul Sørensen, Mikael Thastum, Ronald M Rapee, Charlotte Ulrikka Rask, Kristian Bech Arendt, Per Hove Thomsen
BACKGROUND: Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, social and general development as well as quality of life. The main goal of this study is to examine the effectiveness of a manualized cognitive behavioral therapy (CBT) anxiety program adapted for children with ASD...
April 2, 2018: Trials
https://www.readbyqxmd.com/read/29603576/incidence-of-head-and-neck-cancer-in-children-a-danish-nationwide-study-from-1978-to-2014
#19
Christian Grønhøj, Lisa Hjalgrim, Kathrine K Jakobsen, Birgitte Charabi, Christian Mirian, Gunnar H Laier, Katalin Kiss, Catherine Rechnitzer, Jeppe Friborg, Christian von Buchwald, Thomas Hjuler
BACKGROUND: Pediatric head and neck malignancies are rare and only a few descriptive epidemiological studies have been published. Using unique nationwide registries, we report age-specific incidence rates of head and neck cancer (HNC) among children during four decades. METHODS: Data were obtained from the Danish Cancer Registry. We included children aged 0-14 years diagnosed between January 1, 1978 and December 31, 2014 with extra-orbital, nonskin and nonbone HNC...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29603001/oncological-outcome-following-laparoscopic-versus-open-surgery-for-cancer-in-the-transverse-colon-a-nationwide-cohort-study
#20
Andreas Nordholm-Carstensen, Kristian Kiim Jensen, Peter-Martin Krarup
BACKGROUND: The literature on transverse colonic cancer resection is sparse. The optimal surgical approach for this disease is thus unknown. This study aimed to examine laparoscopic versus open surgery for transverse colonic cancer. METHODS: This study was a nationwide, retrospective cohort study of all patients registered with a transverse colonic cancer in Denmark between 2010 and 2013. Data were obtained from the Danish Colorectal Cancer Group, the Danish Pathology Registry, Danish National Patient Registry, and patients' records...
March 30, 2018: Surgical Endoscopy
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