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https://www.readbyqxmd.com/read/29451070/confounders-other-than-comorbidity-explain-survival-differences-in-danish-and-swedish-ovarian-cancer-patients-a-comparative-cohort-study
#1
Mette Calundann Noer, Pia Leandersson, Torbjørn Paulsen, Susanne Rosthøj, Sofie Leisby Antonsen, Christer Borgfeldt, Claus Høgdall
OBJECTIVE: Danish ovarian cancer (OC) patients have previously been found to have worse prognosis than Swedish patients, and comorbidity has been suggested as a possible explanation for this survival difference. We aimed to investigate the prognostic impact of comorbidity in surgically treated OC patients in Denmark and Sweden. METHODS: This comparative cohort study was based on data from 3118 surgically treated OC patients diagnosed in 2012-2015. The Swedish subcohort (n = 1472) was identified through the Swedish National Quality Register of Gynecological Surgery, whereas the Danish subcohort (n = 1646) originated from the Danish Gynecological Cancer Database...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29447088/increasing-incidence-and-survival-of-head-and-neck-cancers-in-denmark-a-nation-wide-study-from-1980-to-2014
#2
Kathrine Kronberg Jakobsen, Christian Grønhøj, David Hebbelstrup Jensen, Kirstine Kim Schmidt Karnov, Tina Klitmøller Agander, Lena Specht, Christian von Buchwald
BACKGROUND: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014. MATERIAL AND METHODS: All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29444121/no-evidence-of-a-causal-relationship-between-hypothyroidism-and-glaucoma-a-danish-nationwide-register-based-cohort-study
#3
Marianne Thvilum, Frans Brandt, Thomas Heiberg Brix, Laszlo Hegedüs
BACKGROUND: An interrelationship between hypothyroidism and glaucoma, due to a shared autoimmune background or based on deposition of mucopolysaccharides in the trabecular meshwork in the eye, has been suggested but is at present unsubstantiated. Therefore, our objective was to investigate, at a nationwide and population-based level, whether there is such an association. SUBJECTS AND METHODS: Observational cohort study using record-linkage data from nationwide Danish health registers...
2018: PloS One
https://www.readbyqxmd.com/read/29442437/prospective-studies-exploring-the-possible-impact-of-an-id3-polymorphism-on-changes-in-obesity-measures
#4
Mathilde Svendstrup, Emil V R Appel, Camilla H Sandholt, Tarunveer S Ahluwalia, Lars H Ängquist, Betina H Thuesen, Marit E Jørgensen, Oluf Pedersen, Niels Grarup, Torben Hansen, Thorkild I A Sørensen, Henrik Vestergaard
OBJECTIVE: Changes in fat mass depend on adipogenesis and angiogenesis, mechanisms regulated by the inhibitor of differentiation-3 (ID3). Id3 knockout mice showed attenuated increases in BMI and visceral fat mass. We hypothesized that the ID3 missense variant (rs11574-A) would lead to an attenuated increase over time in fat mass, BMI, waist circumference (WC), and waist-hip ratio (WHR) in humans. METHODS: The genotyped study populations included the Obesity Research Group - Genetics (ORGGEN) cohort, a cohort of men with obesity (N = 716) and of randomly selected men (N = 826) from the Danish draft register who were examined at mean ages of 20 and 46 years, and the Inter99 (N = 6,116) and Health2006 (N = 2,761) cohorts, two population-based samples of middle-aged people, followed up after 5 years...
February 14, 2018: Obesity
https://www.readbyqxmd.com/read/29438596/early-discontinuation-of-montelukast-treatment-a-danish-nationwide-utilization-study
#5
Rahmo Ibrahim Farah, Per Damkier, Anders Christiansen, Daniel Pilsgaard Henriksen
Montelukast, a leukotriene receptor antagonist, was marketed in 1998 as an oral supplementary treatment to patients with mild to moderate asthma. The aim of this study was to describe the early discontinuation pattern among montelukast users in Denmark in the period of 1 March 1998 to 31 December 2016, and to identify demographic characteristics possibly associated with early discontinuation. This nationwide drug utilization study was based on data collected from three nationwide Danish registers. All montelukast users who redeemed at least one prescription in the study period were identified...
February 13, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29429425/association-between-alcohol-and-substance-use-disorders-and-psychiatric-service-use-in-patients-with-severe-mental-illness-a-nationwide-danish-register-based-cohort-study
#6
Kirstine Bro Jørgensen, Merete Nordentoft, Carsten Hjorthøj
BACKGROUND: Substance use disorder is highly prevalent in people with psychiatric disorders, and known to impede the psychiatric treatment. Some studies show increased rates of service use, while others show a decrease. These conflicting results are further hampered by a lack of large-scale studies. The aim of this study was to investigate the association between substance use disorder and psychiatric service use in psychiatric patients. METHODS: The study was a prospective registry-based cohort study including patients with severe mental illness...
February 12, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29425977/survival-after-out-of-hospital-cardiac-arrest-in-nursing-homes-a-nationwide-study
#7
Marianne Pape, Shahzleen Rajan, Steen Møller Hansen, Rikke Nørmark Mortensen, Signe Riddersholm, Fredrik Folke, Lena Karlsson, Freddy Lippert, Lars Køber, Gunnar Gislason, Helle Søholm, Mads Wissenberg, Thomas A Gerds, Christian Torp-Pedersen, Kristian Kragholm
BACKGROUND: Survival among nursing home residents who suffers out-of-hospital cardiac arrest (OHCA) is sparsely studied. Deployment of automated external defibrillators (AEDs) in nursing home facilities in Denmark is unknown. We examined 30-day survival following OHCA in nursing and private home residents. METHODS: This register-based, nationwide, follow-up study identified OHCA-patients ≥18 years of age with a resuscitation attempt in nursing homes and private homes using Danish Cardiac Arrest Register data from June 1, 2001 to December 31, 2014...
February 6, 2018: Resuscitation
https://www.readbyqxmd.com/read/29425332/association-between-use-of-phthalate-containing-medication-and-semen-quality-among-men-in-couples-referred-for-assisted-reproduction
#8
A Broe, A Pottegård, J Hallas, T P Ahern, J Fedder, P Damkier
STUDY QUESTION: Does phthalate exposure from prescription drugs affect semen quality? SUMMARY ANSWER: Exposure to phthalate-containing drugs is associated with poor semen quality. WHAT IS KNOWN ALREADY: Phthalates and their metabolites have been shown to disrupt the hormone signalling in animal studies. One study has shown associations between medicinal phthalate exposure and poor semen quality, suggesting similar effects in humans. STUDY DESIGN, SIZE, DURATION: We included 18 515 males with poor semen quality (cases) and 31 063 males with normal semen quality (controls) registered in the Danish IVF Registry from 2006 to 2016...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29424005/the-gift-of-time-school-starting-age-and-mental-health
#9
Thomas S Dee, Hans Henrik Sievertsen
Using linked Danish survey and register data, we estimate the causal effect of age at kindergarten entry on mental health. Danish children are supposed to enter kindergarten in the calendar year in which they turn 6 years. In a "fuzzy" regression-discontinuity design based on this rule and exact dates of birth, we find that a 1-year delay in kindergarten entry dramatically reduces inattention/hyperactivity at age 7 (effect size = -0.73), a measure of self-regulation with strong negative links to student achievement...
February 9, 2018: Health Economics
https://www.readbyqxmd.com/read/29417371/a-randomized-general-population-study-of-the-effects-of-repeated-health-checks-on-incident-diabetes
#10
Tea Skaaby, Torben Jørgensen, Allan Linneberg
BACKGROUND: It is not clear whether offering health checks to the general population can be used to prevent diabetes. Few randomized studies have had a long-term follow-up. We used a randomly selected population cohort as a randomized trial to examine the effect of repeated health checks on the 30-year incidence of diabetes. METHODS: The study included all persons from 11 municipalities in Copenhagen aged 30, 40, 50, and 60 years (n = 17845). An age-stratified and gender-stratified random sample (N = 4789) was invited to participate in a maximum of three health checks between 1982 and 1994 ('intervention group')...
February 7, 2018: Endocrine
https://www.readbyqxmd.com/read/29415870/use-of-primary-healthcare-for-persons-with-epilepsy
#11
Dorte Rytter, Claus Høstrup Vestergaard, Mogens Vestergaard, Jakob Christensen, Bodil Hammer Bech
INTRODUCTION: In Denmark, care and treatment related to epilepsy primarily takes place at specialized hospital departments (neurology and pediatrics). The general practitioner (GP) in contrast is the primary contact and acts as a gatekeeper to the healthcare system for other disorders. The aim of the present study was to describe the utilization of services provided by the GP for children with epilepsy before and after diagnosis of epilepsy and to compare it with that of children without epilepsy...
February 4, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29415279/paternal-and-maternal-obesity-but-not-gestational-weight-gain-is-associated-with-type-1-diabetes
#12
Maria C Magnus, Sjurdur F Olsen, Charlotta Granstrom, Nicolai A Lund-Blix, Jannet Svensson, Jesper Johannesen, Abigail Fraser, Torild Skrivarhaug, Geir Joner, Pål R Njølstad, Ketil Størdal, Lars C Stene
Background: Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI with type 1 diabetes in the offspring will provide further insight into the role of unmeasured confounding by characteristics linked to BMI in both parents. Methods: We studied 132 331 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC) who were born between February 1998 and July 2009...
February 5, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29414634/anaplastic-thyroid-carcinoma-in-denmark-1996-2012-a-national-prospective-study-of-219-patients
#13
Gitte Bjørn Hvilsom, Stefano Christian Londero, Christoffer Holst Hahn, Sten Schytte, Henrik Baymler Pedersen, Peer Christiansen, Katalin Kiss, Stine Rosenkilde Larsen, Marie Louise Jespersen, Giedrius Lelkaitis, Christian Godballe
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients. METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014...
January 31, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29413341/allergic-asthma-is-associated-with-increased-risk-of-infections-requiring-antibiotics
#14
Christian Woehlk, Anna von Bülow, Margit Kriegbaum, Vibeke Backer, Celeste Porsbjerg
BACKGROUND: Viral infection and allergy have been identified as major risk factors for exacerbation in asthma, especially in the presence of both. However, whether patients with allergic asthma are more susceptible to respiratory infections requiring antibiotics remains unknown. OBJECTIVE: To investigate allergy as a risk factor for respiratory infections requiring antibiotics based on register data from a nationwide population of patients with asthma. METHODS: A register-based prospective follow-up study was performed using the Danish prescription database...
February 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29409730/incidence-of-filled-antidepressant-prescriptions-among-people-with-newly-diagnosed-diabetes-and-its-interaction-with-occupational-status-within-the-working-population-of-denmark-1996-2010
#15
Bryan Cleal, Ulrik Haagen Panton, Ingrid Willaing, Richard Holt
AIMS: People with diabetes have heightened levels of depressive symptoms, but less is known about the development of these symptoms in relation to diabetes duration. In this study, we examined the use of prescribed antidepressants in the first five years after diagnosis of diabetes among the working-age population in Denmark. METHODS: All Danish adults aged 18-54 years, diagnosed with diabetes in the study period were included. Diabetes status and purchase of prescription antidepressants were obtained from validated population registers...
February 3, 2018: Primary Care Diabetes
https://www.readbyqxmd.com/read/29409388/are-previous-episodes-of-bacterial-vaginosis-a-predictor-for-vaginal-symptoms-in-breast-cancer-patients-treated-with-aromatase-inhibitors
#16
Malene R Gade, Irina Goukasian, Nathalie Panduro, Claus Kamby, Lisbeth Nilas, Malgorzata K Tuxen, Lars Bjerrum
Objective To estimate the prevalence of vaginal symptoms in postmenopausal women with breast cancer exposed to aromatase inhibitors, and to investigate if the risk of vaginal symptoms is associated with previous episodes of bacterial vaginosis. Methods Patients from Rigshospitalet and Herlev University Hospital, Denmark, were identified through the register of Danish Breast Cancer Cooperation Group and 78 patients participated in the study. Semiquantitave questionnaires and telephone interview were used to assess the prevalence of vaginal symptoms and previous episode(s) of bacterial vaginosis...
January 1, 2018: Post Reproductive Health
https://www.readbyqxmd.com/read/29402404/prognostic-value-of-supar-and-hs-crp-on-cardiovascular-disease
#17
Marie Zöga Diederichsen, Søren Zöga Diederichsen, Hans Mickley, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Kent Lodberg Christensen, Michael Hecht Olsen, Axel Diederichsen, Mette Hjortdal Grønhøj
BACKGROUND AND AIMS: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. METHODS: A population sample of 1179 subjects, free of CV disease was included...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29394927/quantification-of-cancer-risk-in-glomerulonephritis
#18
James Goya Heaf, Alastair Hansen, Gunnar Hellmund Laier
BACKGROUND: The association of increased cancer risk with glomerulonephritis (GN) is well known, but controversy exists concerning which types of GN are involved, and the size of the association. A national registry survey was performed to assess the size of this association, and the temporal relationship of cancer diagnosis to GN diagnosis. METHODS: All patients with biopsy-proven GN between 1985 and 2015 in Denmark were extracted from The Danish Renal Biopsy Registry and the National Pathology Data Bank...
February 2, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29393041/surgical-treatment-for-urinary-incontinence-in-women-danish-nationwide-cohort-studies%C3%A2
#19
Margrethe Foss Hansen
This PhD thesis is based on three original articles. The studies were performed at the Department of Obstetrics and Gynaecology, Herlev University Hospital and at the Center for Clinical Epidemiology, Odense University Hospital. 
Urinary incontinence (UI) is a frequent disorder among women, which for the individual can have physical, psychological and social consequences. The current standard of surgical treatment is the synthetic midurethral sling (MUS), which is a minimal invasive procedure.
As the synthetic MUSs (TVT,TVT-O,TOT) were introduced in the late 1990s, there are only a few studies at the long-term follow-up based on nationwide populations; only a few have reported on the risk of reoperation and there is sparse evidence on which treatment should be used subsequently to failure of synthetic MUSs...
February 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29391832/familial-aggregation-of-tonsillectomy-in-early-childhood-and-adolescence
#20
Peter Bager, Giulia Corn, Jan Wohlfahrt, Heather A Boyd, Bjarke Feenstra, Mads Melbye
Background: The tonsils are immunological gatekeepers against pathogens. Immunological response to tonsillitis may vary clinically from no enlargement of the tonsils to nearly obstructive conditions. In this investigation, we studied the familial aggregation of tonsillectomy, as an indicator of the extent to which tonsillar immune responses to infections might be genetically controlled. Methods: Data on kinship relations and vital status from the Danish Civil Registration System were used to establish a cohort of Danes with relatives born since 1977...
2018: Clinical Epidemiology
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