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https://www.readbyqxmd.com/read/29050688/no-association-between-surgical-delay-and-mortality-following-distal-femoral-fractures-a-study-from-the-danish-fracture-database-collaborators
#1
Anne Marie Nyholm, Henrik Palm, Thomas Kallemose, Anders Troelsen, Kirill Gromov
BACKGROUND: The purpose of this study was to investigate whether surgical delay or the educational level of surgeon is associated with early mortality in patients with distal femoral fractures. METHODS: 392 consecutive patients aged ≥50 years registered in the Danish Fracture Database for surgery of a non-pathological, closed, low-energy distal femoral fracture (AO33A-C) were included. Data included age, gender, American Society of Anaesthesiologists (ASA) score, type of fracture, educational level of surgeon and surgical delay...
October 10, 2017: Injury
https://www.readbyqxmd.com/read/29044769/human-papillomavirus-vaccination-of-adult-women-and-risk-of-autoimmune-and-neurological-diseases
#2
A Hviid, H Svanström, N M Scheller, O Grönlund, B Pasternak, L Arnheim-Dahlström
BACKGROUND: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. OBJECTIVE: We took advantage of the unique Danish and Swedish nationwide healthcare registers to conduct a cohort study comparing incidence rate ratios (RRs) of 45 preselected serious chronic diseases in quadrivalent HPV (qHPV)-vaccinated and qHPV-unvaccinated adult women 18-44 years of age...
October 18, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29042817/accuracy-of-the-hypospadias-diagnoses-and-surgical-treatment-registrations-in-the-danish-national-patient-register
#3
Linn Håkonsen Arendt, Andreas Ernst, Morten Søndergaard Lindhard, Anne Aggerholm Jønsson, Tine Brink Henriksen, Jørn Olsen, Jorgen Thorup, L Henning Olsen, Cecilia Høst Ramlau-Hansen
PURPOSE: The Danish National Health registers provide a valuable data source that offers unique opportunities for observational research, including studies on the congenital anomaly hypospadias. The accuracy of the diagnosis and surgical treatment registration of hypospadias in the Danish National Patient Register (DNPR) remains unknown. PATIENTS AND METHODS: We randomly sampled 500 patients diagnosed with hypospadias in the DNPR from January 1, 1995 to December 31, 2012...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29036292/association-between-implantable-cardioverter-defibrillator-therapy-and-different-lead-positions-in-patients-with-cardiac-resynchronization-therapy
#4
Mads Brix Kronborg, Jens Brock Johansen, Jens Haarbo, Sam Riahi, Berit Thornvig Philbert, Ole Dan Jørgensen, Jens Cosedis Nielsen
Aims: To evaluate the impact of different right and left ventricular lead positions (RV-LP and LV-LP) on the risk of therapy for ventricular tachycardia/ventricular fibrillation in patients with a cardiac resynchronization therapy device (CRT-D). Methods and results: We performed a large nationwide cohort study on patients in Denmark receiving a CRT-D device from 2008 to 2012 from the Danish Pacemaker and implantable cardioverter defibrillator (ICD) registry. Lead positions were registered during the implantation and categorized as anterior/lateral/posterior and basal/mid-ventricular/apical for the LV-LP, and as apical/non-apical for the RV-LP...
September 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29027840/male-factor-infertility-and-risk-of-multiple-sclerosis-a-register-based-cohort-study
#5
Clara Helene Glazer, Sandra Søgaard Tøttenborg, Aleksander Giwercman, Elvira Vaclavik Bräuner, Michael L Eisenberg, Ditte Vassard, Melinda Magyari, Anja Pinborg, Lone Schmidt, Jens Peter Bonde
BACKGROUND: Gender, possibly due to the influence of gonadal hormones, is presumed to play a role in the pathogenesis of multiple sclerosis (MS), but no studies have evaluated whether male infertility is associated with MS. OBJECTIVE: To study the association between male factor infertility and prevalent as well as incident MS. METHOD: Our cohort was established by linkage of the Danish National in vitro fertilization (IVF) registry to The Danish Multiple Sclerosis Registry and consisted of 51,063 men whose partners had undergone fertility treatment in all public and private fertility clinics in Denmark between 1994 and 2015...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29020388/temporal-trends-in-atrial-fibrillation-recurrence-rates-after-ablation-between-2005-and-2014-a-nationwide-danish-cohort-study
#6
Jannik Langtved Pallisgaard, Gunnar Hilmar Gislason, Jim Hansen, Arne Johannessen, Christian Torp-Pedersen, Peter Vibe Rasmussen, Morten Lock Hansen
Aims: During the last decade, ablation has increasingly been used in rhythm control management of patients with atrial fibrillation (AF). Over time, experience and techniques have improved and indications for ablation have expanded. The purpose of this study was to investigate whether the recurrence rate of AF following ablation has improved during last decade. Methods and results: Through Danish nationwide registers, all patients with first-time AF ablation, between 2005 and 2014 in Denmark were identified...
August 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29017177/patients-with-newly-diagnosed-rheumatoid-arthritis-are-at-increased-risk-of-diabetes-mellitus-an-observational-cohort-study
#7
Amir Emamifar, Klaus Levin, Inger Marie Jensen Hansen
AIMS: To reveal the prevalence of Diabetes Mellitus (DM) in patients with newly diagnosed Rheumatoid Arthritis (RA) and evaluate the association between clinical characteristics of RA and DM as well as treatment response in newly diagnosed RA patients with DM. METHODS: Newly diagnosed, adult, RA patients, who were registered in Danish Danbio since 1st January 2010, were included. Patients' demographics, serology results including rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP) and antinuclear antibody (ANA) as well as disease activity score in 28 joints-C-reactive protein (DAS28-CRP) at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danbio Registry...
September 28, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29016817/association-between-socioeconomic-factors-and-icd-implantation-in-a-publicly-financed-health-care-system-a-danish-nationwide-study
#8
Matilde Winther-Jensen, Christian Hassager, Jens Flensted Lassen, Lars Køber, Christian Torp-Pedersen, Steen Møller Hansen, Freddy Lippert, Erika Frischknecht Christensen, Kristian Kragholm, Jesper Kjaergaard
Aims: For patients surviving out-of-hospital cardiac arrest (OHCA) with a shockable rhythm, implantable cardioverter defibrillator (ICD) is recommended for non-reversible causes of arrest. We aimed to determine factors associated with implantation of ICD and survival in patients surviving non-AMI OHCA in a nationwide register covering all OHCAs in Denmark. Methods and results: We identified 36 950 OHCAs between 2001 and 2012, 1700 of whom were ICD naïve, ≥18 years, of non-AMI cardiac aetiology and surviving until discharge...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28993421/burden-of-mortality-attributable-to-diagnosed-diabetes-a-nationwide-analysis-based-on-claims-data-from-65-million-people-in-germany
#9
Esther Jacobs, Annika Hoyer, Ralph Brinks, Oliver Kuss, Wolfgang Rathmann
OBJECTIVE: In Germany, as in many other countries, nationwide data on mortality attributable to diagnosed diabetes are not available. This study estimated the absolute number of excess deaths associated with diabetes (all types) and type 2 diabetes in Germany. RESEARCH DESIGN AND METHODS: A prevalence approach that included nationwide routine data from 64.9 million people insured in the German statutory health insurance system in 2010 was used for the calculation...
October 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28992924/computional-algorithm-for-lifetime-exposure-to-antimicrobials-in-pigs-using-register-data-the-lea-algorithm
#10
Anna Camilla Birkegård, Vibe Dalhoff Andersen, Tariq Halasa, Vibeke Frøkjær Jensen, Nils Toft, Håkan Vigre
Accurate and detailed data on antimicrobial exposure in pig production are essential when studying the association between antimicrobial exposure and antimicrobial resistance. Due to difficulties in obtaining primary data on antimicrobial exposure in a large number of farms, there is a need for a robust and valid method to estimate the exposure using register data. An approach that estimates the antimicrobial exposure in every rearing period during the lifetime of a pig using register data was developed into a computational algorithm...
October 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28988695/temporal-trends-in-clinical-and-pathological-characteristics-for-men-undergoing-radical-prostatectomy-between-1995-and-2013-at-rigshospitalet-copenhagen-denmark-and-stanford-university-hospital-united-states
#11
Mathias Dyrberg Loft, Kasper Drimer Berg, Andreas Kjaer, Peter Iversen, Michelle Ferrari, Chiyuan A Zhang, Klaus Brasso, James D Brooks, Martin Andreas Røder
PURPOSE: To analyze how prostate-specific antigen (PSA) screening and practice patterns has affected trends in tumor characteristics in men undergoing radical prostatectomy (RP) in the United States and Denmark. Unlike in the United States, PSA screening has not been recommended in Denmark. PATIENTS AND METHODS: We performed an observational register study using pre- and postoperative data on 2168 Danish patients from Rigshospitalet, Copenhagen, Denmark, and 2236 patients from Stanford University Hospital, Stanford, CA, who underwent RP between 1995 and 2013...
September 6, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28987712/heritability-of-schizophrenia-and-schizophrenia-spectrum-based-on-the-nationwide-danish-twin-register
#12
Rikke Hilker, Dorte Helenius, Birgitte Fagerlund, Axel Skytthe, Kaare Christensen, Thomas M Werge, Merete Nordentoft, Birte Glenthøj
BACKGROUND: Twin studies have provided evidence that both genetic and environmental factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples have varied methodologically. This study provides updated heritability estimates based on nationwide twin data and an improved statistical methodology. METHODS: Combining two nationwide registers, the Danish Twin Register and the Danish Psychiatric Research Register, we identified a sample of twins born between 1951 and 2000 (N = 31,524 twin pairs)...
September 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28986155/using-scores-to-identify-patients-at-risk-of-short-term-mortality-at-arrival-to-the-acute-medical-unit-a-validation-study-of-six-existing-scores
#13
Mikkel Brabrand, Peter Hallas, Søren Nygaard Hansen, Kristian Møller Jensen, Janni Lynggård Bo Madsen, Stefan Posth
INTRODUCTION: "Early warning scores" (EWS) have been developed to quantify levels of vital sign abnormality. However, many scores have not been validated. The aim of this study was to validate six scores that all rely on vital signs: Rapid Acute Physiology Score (RAPS), Rapid Emergency Medicine Score (REMS) and the National Early Warning Score (NEWS) and the Goodacre, Groarke and Worthing physiological scores. METHODS: A posthoc single-center observational cohort study of prospectively collected vital signs on acutely admitted medical patients to a Danish hospital...
October 3, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28983719/glucose-patterns-during-an-oral-glucose-tolerance-test-and-associations-with-future-diabetes-cardiovascular-disease-and-all-cause-mortality-rate
#14
Adam Hulman, Dorte Vistisen, Charlotte Glümer, Michael Bergman, Daniel R Witte, Kristine Færch
AIMS/HYPOTHESIS: In addition to blood glucose concentrations measured in the fasting state and 2 h after an OGTT, intermediate measures during an OGTT may provide additional information regarding a person's risk of future diabetes and cardiovascular disease (CVD). First, we aimed to characterise heterogeneity of glycaemic patterns based on three time points during an OGTT. Second, we compared the incidences of diabetes and CVD and all-cause mortality rates among those with different patterns...
October 6, 2017: Diabetologia
https://www.readbyqxmd.com/read/28981984/obstetrical-complications-in-dichorionic-twin-pregnancies-in-women-with-polycystic-ovary-syndrome
#15
Fjola Jonsdottir, Lisbeth Nilas, Kirsten R Andreasen, Jørgen Grinsted, Michael Christiansen, Paula L Hedley, Klara V Naver
INTRODUCTION: Both women with polycystic ovary syndrome (PCOS) and women with twin pregnancies have increased risk of adverse pregnancy outcome. The aim of this study was to investigate the impact of PCOS and maternal androgen levels on the outcome of dichorionic twin pregnancy. MATERIAL AND METHODS: A retrospective study of 360 women with dichorionic twin pregnancies: 72 PCOS women from a fertility clinic (years 1997 to 2010) and 288 non-PCOS women from a hospital cohort (years 2005 to 2007)...
October 5, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28980388/incidence-and-risk-factors-for-parastomal-bulging-in-patients-with-ileostomy-or-colostomy-a-register-based-study-using-data-from-the-danish-stoma-database-capital-region
#16
Rune M Andersen, Tobias W Klausen, Anne K Danielsen, Anders Vinther, Ismail Gögenur, Thordis Thomsen
AIM: To investigate incidence and risk factors for parastomal bulging, a clinically important complication, in patients with an ileostomy or colostomy. METHOD: The Danish Stoma Database Capital Region prospectively collects data on patients with a stoma up to a year after surgery. Stoma care nurses clinically assessed the main outcome, parastomal bulging. We linked data from the Stoma Database to data from the Danish Anaesthesia Database. Cumulative incidence of parastomal bulging over the first year was calculated with death and stoma reversal as competing risks...
October 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28980135/big-data-and-health-research-the-governance-challenges-in-a-mixed-data-economy
#17
Søren Holm, Thomas Ploug
Denmark is a society that has already moved towards Big Data and a Learning Health Care System. Data from routine healthcare has been registered centrally for years, there is a nationwide tissue bank, and there are numerous other available registries about education, employment, housing, pollution, etcetera. This has allowed Danish researchers to study the link between exposures, genetics and diseases in a large population. This use of public registries for scientific research has been relatively uncontroversial and has been supported by facilitative regulation that allows data to be used without the consent of data subjects...
October 4, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28979164/psychiatric-conditions-and-general-practitioner-attendance-prior-to-hpv-vaccination-and-the-risk-of-referral-to-a-specialized-hospital-setting-because-of-suspected-adverse-events-following-hpv-vaccination-a-register-based-matched-case-control-study
#18
Tina Hovgaard Lützen, Bodil Hammer Bech, Jesper Mehlsen, Claus Høstrup Vestergaard, Lene Wulff Krogsgaard, Jørn Olsen, Mogens Vestergaard, Oleguer Plana-Ripoll, Dorte Rytter
AIM: No association between human papilloma virus (HPV) vaccination and numerous diseases has been found. Still, a large number of Danish women are reporting suspected adverse events. Other factors may play a role, and the aim of this study is to examine the association between psychiatric conditions, general practitioner (GP) attendance and indicators of psychological symptoms prior to HPV vaccination and the risk of referral to an HPV center following vaccination. STUDY DESIGN AND SETTING: Register-based, matched case-control study...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28975886/intra-corporeal-anastomosis-in-laparoscopic-surgery-for-benign-colorectal-disease
#19
Jacob Antonsen, Rogini Balachandran, Finn Stigsen Holm, Ismail Gögenur
INTRODUCTION: Recent studies have described the benefits of performing bowel resections for benign and malignant diseases as a total laparoscopic procedure with intra-corporeal anastomosis. We describe our preliminary experience with total laparoscopic surgery for benign lower gastrointestinal diseases. METHODS: All patients (n = 32) who had received elective bowel surgery with intra-corporeal anastomosis for benign diseases between November 2013 and August 2015 were included in this retrospective study...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28975885/pet-ct-findings-in-patients-with-polymyalgia-rheumatica-without-symptoms-of-cranial-ischaemia
#20
Alexander Lund-Petersen, Anne Voss, Helle Laustrup
INTRODUCTION: Polymyalgia rheumatica (PMR) is an inflammatory disorder that affects the elderly. At present, evidence is limited regarding the usefulness of positron emission tomography-computed tomography (PET-CT) in the diagnosis of PMR. This study aimed to compare patient characteristics and symptoms with PET-CT findings in a Danish population of PMR patients without clinical symptoms of giant cell arteritis. METHODS: The medical records of 50 Danish PET-CT-scanned patients with PMR were reviewed...
October 2017: Danish Medical Journal
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