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https://www.readbyqxmd.com/read/28430992/identifying-practice-related-factors-for-high-volume-prescribers-of-antibiotics-in-danish-general-practice
#1
Rune Aabenhus, Volkert Siersma, Håkon Sandholdt, Rasmus Køster-Rasmussen, Malene Plejdrup Hansen, Lars Bjerrum
Objectives: In Denmark, general practice is responsible for 75% of antibiotic prescribing in the primary care sector. We aimed to identify practice-related factors associated with high prescribers, including prescribers of critically important antibiotics as defined by WHO, after accounting for case mix by practice. Methods: We performed a nationwide register-based survey of antibiotic prescribing in Danish general practice from 2012 to 2013. The unit of analysis was the individual practice...
April 19, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28427946/is-an-early-age-at-illness-onset-in-schizophrenia-associated-with-increased-genetic-susceptibility-analysis-of-data-from-the-nationwide-danish-twin-register
#2
Rikke Hilker, Dorte Helenius, Birgitte Fagerlund, Axel Skytthe, Kaare Christensen, Thomas M Werge, Merete Nordentoft, Birte Glenthøj
BACKGROUND: Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability. A twin approach can be valuable, because it allows for the investigation of specific illness markers in individuals with a shared genetic background. METHODS: We linked nationwide registers to identify a cohort of twin pairs born in Denmark from 1951 to 2000 (N=31,524 pairs), where one or both twins had a diagnosis in the schizophrenia spectrum...
April 6, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28422885/cancer-of-unknown-primary-registered-procedures-compared-with-national-integrated-cancer-pathway-for-illuminating-external-validity
#3
Anne-Kirstine Dyrvig, Knud Bonnet Yderstræde, Oke Gerke, Peter Bjødstrup Jensen, Søren Hess, Poul Flemming Høilund-Carlsen, Anders Green
Cancer of unknown primary (CUP) ranges within top 10 cancers in both incidence and mortality. As primary identification is crucial to choosing treatment, guidelines on CUP emphasize the diagnostic strategy. Whether guidelines are complied with, or if they are indeed helpful, is however unclear. We compared procedures performed in suspected CUP patients with recommendations of national guidelines to assess external validity of guidelines.The Danish National Patient Registry (NPR) comprising population data was utilized to identify the suspected CUP patients during 2009 to 2010 and explore exposure to procedures and patient survival...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422339/prenatal-exposure-to-%C3%AE-2-adrenoreceptor-agonists-and-the-risk-of-autism-spectrum-disorders-in-offspring
#4
XiuJuan Su, Wei Yuan, JianPing Chen, MaoHua Miao, Jørn Olsen, Lars Henning Pedersen, Hong Liang, Jiong Li
PURPOSE: We aimed to examine the risk of autism spectrum disorders (ASDs) in the offspring who were exposed to maternal use of β2-adrenoreceptor agonist (β2AA) during pregnancy. METHODS: This is a population-based cohort study including all live singleton births in Denmark from 1 January 1997 to 31 December 2008. Children born to mothers who used β2AA during pregnancy were categorized as exposed, and all other children were included in the unexposed group. Cases of ASDs were identified from the Danish Psychiatric Central Register and the Danish Patient Register...
April 19, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28420655/syncope-and-its-impact-on-occupational-accidents-and-employment-a-danish-nationwide-retrospective-cohort-study
#5
Anna-Karin Numé, Kristian Kragholm, Nicolas Carlson, Søren L Kristensen, Henrik Bøggild, Mark A Hlatky, Christian Torp-Pedersen, Gunnar Gislason, Martin H Ruwald
BACKGROUND: First-time syncopal episodes usually occur in adults of working age, but their impact on occupational safety and employment remains unknown. We examined the associations of syncope with occupational accidents and termination of employment. METHODS AND RESULTS: Through linkage of Danish population-based registers, we included all residents 18 to 64 years from 2008 to 2012. Among 3 410 148 eligible individuals, 21 729 with a first-time diagnosis of syncope were identified, with a median age 48...
April 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28420369/improving-the-effectiveness-of-sickness-benefit-case-management-through-a-public-private-partnership-a-difference-in-difference-analysis-in-eighteen-danish-municipalities
#6
Malene Rode Larsen, Birgit Aust, Jan Høgelund
BACKGROUND: The aim of this study was to investigate whether a multidimensional public-private partnership intervention, focussing on improving the quality and efficiency of sickness benefit case management, reduced the sickness benefit duration and the duration until self-support. METHODS: We used a difference-in-difference (DID) design with six intervention municipalities and 12 matched control municipalities in Denmark. The study sample comprised 282,103 sickness benefit spells exceeding four weeks...
April 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28416794/stability-of-the-frequent-copd-exacerbator-in-the-general-population-a-danish-nationwide-register-based-study
#7
Mette Reilev, Jesper Lykkegaard, Anders Halling, Jørgen Vestbo, Jens Søndergaard, Anton Pottegård
Exacerbation frequency is central in treatment strategies for chronic obstructive pulmonary disease. However, whether chronic obstructive pulmonary disease patients from the general population with frequent exacerbations continue to have frequent exacerbations over an extended period of time is currently unknown. In this study, we aimed to investigate the stability of the frequent exacerbator in a population-based setting. To this end, we conducted a nationwide register-based descriptive study with a 10-year follow-up period of chronic obstructive pulmonary disease patients with at least one medically treated exacerbation in 2003...
April 17, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28416179/increased-risk-of-ventral-hernia-recurrence-after-pregnancy-a%C3%A2-nationwide-register-based-study
#8
Erling Oma, Kristian K Jensen, Lars N Jorgensen
BACKGROUND: Female patients of reproductive age constitute a substantial portion of patients undergoing ventral hernia repair, however the impact of pregnancy on the risk of recurrence is scarcely documented. The aim of the study was to evaluate if pregnancy following ventral hernia repair was associated with an increased risk of recurrence. METHODS: This nationwide cohort study included all female patients of reproductive age registered in the Danish Ventral Hernia Database with ventral hernia repair between 2007 and 2013...
April 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28411390/statin-use-and-mortality-among-ovarian-cancer-patients-a-population-based-cohort-study
#9
Freija Verdoodt, Merete Kjaer Hansen, Susanne K Kjaer, Anton Pottegård, Søren Friis, Christian Dehlendorff
Statin use has been suggested to improve prognosis in cancer patients, however, for ovarian cancer, the evidence is sparse. From the Danish Cancer Registry, we identified patients aged 30-84 years with a histologically verified first diagnosis of epithelial ovarian cancer between 2000-2013. Data on filled prescriptions, death, and potential confounding factors were obtained from nationwide registers. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals for the association between post-diagnostic statin use and all-cause or cancer-specific mortality...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28409477/ethnic-differences-in-persistence-with-copd-medications-a-register-based-study
#10
Yusun Hu, Lourdes Cantarero-Arévalo, Anne Frølich, Ramune Jacobsen
BACKGROUND: Long-acting bronchodilators (LABDs) are recommended as a first-line maintenance therapy in patients with moderate or severe chronic obstructive pulmonary disease (COPD). The aim of the study was to explore potential ethnic differences in persistence with LABD in COPD patients. METHODS: A cohort of COPD patients diagnosed in 2003-2007 in Copenhagen, Denmark, was followed for 2 years in the Danish national registers. According to the number of the LABD medications dispensed, individuals were categorized into three therapy groups: monotherapy, drug combination therapy, and multiple drug therapy...
April 13, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28408193/imipramine-versus-placebo-for-multiple-functional-somatic-syndromes-stress-3-a-double-blind-randomised-study
#11
Johanne L Agger, Andreas Schröder, Lise K Gormsen, Jens S Jensen, Troels S Jensen, Per K Fink
BACKGROUND: Functional somatic syndromes, including chronic fatigue syndrome or irritable bowel syndrome, often co-exist. Treatment guidelines supported by high quality evidence exist for most functional somatic syndromes, but are lacking for multiple comorbid functional somatic syndromes. We aimed to assess the effect of the tricyclic antidepressant, imipramine, in patients with multiple functional somatic syndromes defined by the criteria for multiorgan bodily distress syndrome, a unifying diagnosis that encompasses most functional somatic syndromes and somatoform disorders...
April 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28403839/transfer-between-hospitals-as-a-predictor-of-delay-in-diagnosis-and-treatment-of-patients-with-non-small-cell-lung-cancer-a-register-based-cohort-study
#12
Maria Iachina, Erik Jakobsen, Anne Kudsk Fallesen, Anders Green
BACKGROUND: Lung cancer is the second most frequent cancer diagnosis in Denmark. Although improved during the last decade, the prognosis of lung cancer is still poor with an overall 5-year survival rate of approximately 12%. Delay in diagnosis and treatment of lung cancer has been suggested as a potential cause of the poor prognosis and as consequence, fast track cancer care pathways were implemented describing maximum acceptable time thresholds from referral to treatment. In Denmark, patients with lung cancer are often transferred between hospitals with diagnostic facilities to hospitals with treatment facilities during the care pathway...
April 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28402064/use-of-psychotropic-medications-and-visits-to-psychiatrists-and-psychologists-among-individuals-with-nonsyndromic-oral-clefts-a-population-based-cohort-study
#13
Dorthe Almind Pedersen, Ida Hageman, George L Wehby, Kaare Christensen
BACKGROUND: Oral clefts (OCs) are among the most common congenital malformations and can have a large impact on the life of the affected individual. Research findings regarding the psychological and psychosocial consequences of OC are inconclusive. METHODS: Using Danish nationwide registers, we investigated redeemed prescriptions of psychotropic medication during 1996 to 2012 and visits to psychiatrists and psychologists during 1996 to 2011 among individuals born with nonsyndromic OC in Denmark between 1936 and 2009 and a comparison cohort of individuals without OC...
April 12, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28399909/myplan-mobile-phone-application-to-manage-crisis-of-persons-at-risk-of-suicide-study-protocol-for-a-randomized-controlled-trial
#14
Kate Andreasson, Jesper Krogh, Per Bech, Hanne Frandsen, Niels Buus, Barbara Stanley, Ad Kerkhof, Merete Nordentoft, Annette Erlangsen
BACKGROUND: Persons with a past episode of self-harm or severe suicidal ideation are at elevated risk of self-harm as well as dying by suicide. It is well established that suicidal ideation fluctuates over time. Previous studies have shown that a personal safety plan can assist in providing support, when a person experiences suicide ideation, and help seeking professional assistance if needed. The aim of the trial is to determine whether a newly developed safety mobile app is more effective in reducing suicide ideation and other symptoms, compared to a safety plan on paper...
April 11, 2017: Trials
https://www.readbyqxmd.com/read/28399821/comparison-of-surveillance-based-metrics-for-the-assessment-and-monitoring-of-disease-detection-simulation-study-about-type-2-diabetes
#15
Ralph Brinks, Annika Hoyer, Deborah B Rolka, Oliver Kuss, Edward W Gregg
BACKGROUND: Screening and detection of cases are a common public health priority for treatable chronic conditions with long subclinical periods. However, the validity of commonly-used metrics from surveillance systems for rates of detection (or case-finding) have not been evaluated. METHODS: Using data from a Danish diabetes register and a recently developed illness-death model of chronic diseases with subclinical conditions, we simulate two scenarios of different performance of case-finding...
April 11, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28391448/type-of-incision-does-not-predict-abdominal-wall-outcome-after-emergency-surgery-for-colonic-anastomotic-leakage
#16
Kristian Kiim Jensen, Erling Oma, Henrik Harling, Peter-Martin Krarup
PURPOSE: Most literature on abdominal incision is based on patients undergoing elective surgery. In a cohort of patients with anastomotic leakage after colonic cancer resection, we analyzed the association between type of incision, fascial dehiscence, and incisional hernia. METHODS: Data were extracted from the Danish Colorectal Cancer Group database and merged with information from the Danish National Patient Register. All patients with anastomotic leakage after colonic resection in Denmark from 2001 until 2008 were included and surgical records on re-operations were retrieved...
April 8, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28391237/association-between-baseline-vitamin-d-metabolite-levels-and-long-term-cardiovascular-events-in-patients-with-rheumatoid-arthritis-from-the-cimestra-trial-protocol-for-a-cohort-study-with-patient-record-evaluated-outcomes
#17
M Herly, K Stengaard-Pedersen, K Hørslev-Petersen, M L Hetland, M Østergaard, R Christensen, B B Løgstrup, P Vestergaard, J Pødenphant, P Junker, T Ellingsen
INTRODUCTION: Cardiovascular morbidity and mortality is increased in patients with rheumatoid arthritis (RA), and among these patients, the prevalence of hypovitaminosis D is high. Moreover, low vitamin D levels have been associated with increased cardiovascular risk in healthy subjects. OBJECTIVE: To evaluate the long-term risk of cardiovascular events in patients having low total 25-hydroxyvitamin D levels at baseline compared with patients with normal levels, in an efficiently treated, closed cohort of patients with an early diagnosis of RA...
April 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28389225/prognosis-of-asymptomatic-and-symptomatic-undiagnosed-copd-in-the-general-population-in-denmark-a-prospective-cohort-study
#18
Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard, Jørgen Vestbo, Peter Lange
BACKGROUND: COPD can be diagnosed early using spirometry, but spirometry use is only recommended in symptomatic smokers, even though early stages of COPD can be asymptomatic. We investigated the prognosis of individuals with asymptomatic and symptomatic, undiagnosed COPD in the general population in Denmark. METHODS: In this prospective cohort study, we analysed data from 95 288 individuals aged 20-100 years from the Copenhagen General Population Study. 32 518 (34%) of these individuals were regarded as being at high risk for COPD (defined as individuals aged 40 years or older, with cumulative tobacco consumption of ten pack-years or higher, and without self-reported or a previous hospital contact for asthma)...
April 4, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28385304/functional-testing-or-coronary-computed-tomography-angiography-in-patients-with-stable%C3%A2-coronary-artery-disease
#19
Mads E Jørgensen, Charlotte Andersson, Bjarne L Nørgaard, Jawdat Abdulla, Jacqueline B Shreibati, Christian Torp-Pedersen, Gunnar H Gislason, Richard E Shaw, Mark A Hlatky
BACKGROUND: The choice of either anatomical or functional noninvasive testing to evaluate suspected coronary artery disease might affect subsequent clinical management and outcomes. OBJECTIVES: This study analyzed the association of initial noninvasive cardiac testing in outpatients with stable symptoms, with subsequent use of medications, invasive procedures, and clinical outcomes. METHODS: We studied patients enrolled in a Danish nationwide register who underwent initial noninvasive cardiac testing with either coronary computed tomography angiography (CTA) or functional testing (exercise electrocardiography or nuclear stress testing) from 2009 to 2015...
April 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28385171/children-and-adolescents-admitted-to-a-university-level-trauma-centre-in-denmark-2002-2011
#20
Danny Stefan Ekström, Rasmus Hviid Larsen, Jens Martin Lauritsen, Christian Færgemann
INTRODUCTION: The epidemiology of children or adolescents admitted to a Scandinavian trauma centre is largely unknown. The aim of this paper was to describe the epi-demiology and severity of potentially severely injured children and adolescents admitted to a university hospital trauma centre. METHODS: This was a descriptive study of all children and adolescents aged 0-17 admitted to the university level trauma centre at Odense University Hospital, Denmark in the 2002-2011 period...
April 2017: Danish Medical Journal
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