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https://www.readbyqxmd.com/read/28225200/alcohol-dependence-and-risk-of-somatic-diseases-and-mortality-a-cohort-study-in-19-002-men-and-women-attending-alcohol-treatment
#1
Charlotte Holst, Janne Schurmann Tolstrup, Holger Jelling Sørensen, Ulrik Becker
AIMS: To (1) estimate sex-specific risks of a comprehensive spectrum of somatic diseases in alcohol dependent individuals versus a control population, and in the same population to (2) estimate sex-specific risks of dying from the examined somatic diseases. DESIGN: Register-based matched cohort study. Alcohol dependent individuals were identified from an alcohol treatment database. Controls were randomly selected from the Danish Civil Registration System. Information on somatic diseases obtained from the Danish National Patient Registry and causes of death obtained from the Cause of Death Registry...
February 22, 2017: Addiction
https://www.readbyqxmd.com/read/28219489/associations-between-autoimmune-diseases-and-attention-deficit-hyperactivity-disorder-a%C3%A2-nationwide-study
#2
Philip Rising Nielsen, Michael Eriksen Benros, Søren Dalsgaard
OBJECTIVE: Recent studies have suggested that autoimmune diseases and immune activation play a part in the pathogenesis of different neurodevelopmental disorders. This study investigated the association between a personal history and a family history of autoimmune disease and the risk of developing attention-deficit/hyperactivity disorder (ADHD). METHOD: A cohort was formed of all singletons born in Denmark from 1990 to 2007, resulting in a study population of 983,680 individuals followed from 1995 to 2012...
March 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28219025/mortality-in-individuals-with-disruptive-behavior-disorders-diagnosed-by-specialist-services-a-nationwide-cohort-study
#3
James G Scott, Marianne Giørtz Pedersen, Holly E Erskine, Aida Bikic, Ditte Demontis, John J McGrath, Søren Dalsgaard
Disruptive behavior disorders (DBDs), inclusive of oppositional defiant disorder (ODD) and conduct disorder (CD), are associated with outcomes likely to increase risk of mortality. Using Danish National Registers, a total of 1.92 million individuals including 9495 individuals with DBDs diagnosed by specialist services were followed from their first birthday to 2013. Those with and without DBDs were compared using mortality rate ratios (MRRs) estimated using Poisson regression and adjusted for calendar period, age, sex, family history of psychiatric disorders, maternal age at time of birth, paternal age at time of birth, parental education status, and parental employment status...
February 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28215901/physical-health-medication-and-healthcare-utilization-among-70-year-old-people-with-schizophrenia-a-nationwide-danish-register-study
#4
Maria Brink, Anders Green, Anders Bo Bojesen, J Steven Lamberti, Yeates Conwell, Kjeld Andersen
OBJECTIVES: In light of the excess early mortality in schizophrenia, mainly due to physical illnesses, we investigated medical comorbidity, use of medication, and healthcare utilization among individuals with schizophrenia who survived into older ages to uncover potential factors contributing to their longevity. DESIGN: A nationwide register-based case-control study comparing 70-year-olds with and without schizophrenia. SETTING: Cases were drawn from the Danish Psychiatric Central Register...
January 9, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28213927/long-term-hospitalisation-rates-among-5-year-survivors-of-hodgkin-lymphoma-in-adolescence-or-young-adulthood-a-nationwide-cohort-study
#5
Kathrine Rugbjerg, Maja Maraldo, Marianne C Aznar, David J Cutter, Sarah C Darby, Lena Specht, Jørgen H Olsen
In the present study, we report on the full range of physical diseases acquired by survivors of Hodgkin lymphoma diagnosed in adolescence or young adulthood. In a Danish nationwide population-based cohort study, 1768 five-year survivors of Hodgkin lymphoma diagnosed at ages 15-39 years during 1943-2004 and 228,447 comparison subjects matched to survivors on age and year of birth were included. Hospital discharge diagnoses and bed-days during 1977-2010 were obtained from the Danish Patient Register for 145 specific disease categories gathered in 14 main diagnostic groups...
February 18, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28213896/filaggrin-loss-of-function-mutations-atopic-dermatitis-and-risk-of-actinic-keratosis-results-from-two-cross-sectional-studies
#6
Y M F Andersen, A Egeberg, E Balslev, C L T Jørgensen, P B Szecsi, S Stender, J Kaae, A Linneberg, G Gislason, L Skov, P M Elias, J P Thyssen
BACKGROUND: Common loss-of-function mutations in filaggrin gene (FLG) represent a strong genetic risk factor for atopic dermatitis (AD). Homozygous mutation carriers typically display ichthyosis vulgaris (IV) and many have concomitant AD. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas. OBJECTIVE: The first objective was to examine the association between FLG mutations and actinic keratosis (AK)...
February 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28210793/a-national-population-based-cohort-study-of-urethral-injection-therapy-for-female-stress-and-mixed-urinary-incontinence-the-danish-urogynaecological-database-2007-2011
#7
Margrethe Foss Hansen, Gunnar Lose, Ulrik Schiøler Kesmodel, Kim Oren Gradel
INTRODUCTION AND HYPOTHESIS: Urethral injection therapy (UIT) has been performed since the early 20th century and a variety of agents have been launched. In 2006, polyacrylamide hydrogel (PAGH) was introduced and is now widely used as an agent. The objective was to evaluate the efficacy of PAGH based on a national population over a 5-year period (2007-2011) and the influence of patient-related factors, surgeon experience, and department volume. METHODS: A retrospective cohort study was carried out based on data from the Danish Urogynaecological Database (DugaBase)...
February 16, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28199869/antipsychotic-treatment-effects-on-cardiovascular-cancer-infection-and-intentional-self-harm-as-cause-of-death-in-patients-with-alzheimer-s-dementia
#8
R-E Nielsen, A Lolk, M Rodrigo-Domingo, J-B Valentin, K Andersen
BACKGROUND: Alzheimer's disease (AD), the most common disease causing dementia, is linked to increased mortality. However, the effect of antipsychotic use on specific causes of mortality has not yet been investigated thoroughly. METHODS: Utilizing the Danish nationwide registers, we defined a cohort of patients diagnosed with AD. Utilizing separate Cox regressions for specific causes of mortality, we investigated the effects of cumulative antipsychotic dosage after diagnosis and current antipsychotic exposure in the time period 2000-2011...
December 12, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28193288/accreditation-in-general-practice-in-denmark-study-protocol-for-a-cluster-randomized-controlled-trial
#9
Merethe K Andersen, Line B Pedersen, Volkert Siersma, Flemming Bro, Susanne Reventlow, Jens Søndergaard, Marius Brostrøm Kousgaard, Frans B Waldorff
BACKGROUND: Accreditation is used increasingly in health systems worldwide. However, there is a lack of evidence on the effects of accreditation, particularly in general practice. In 2016 a mandatory accreditation scheme was initiated in Denmark, and during a 3-year period all practices, as default, should undergo accreditation according to the Danish Healthcare Quality Program. The aim of this study is primarily to evaluate the effects of a mandatory accreditation scheme. METHODS/DESIGN: The study is conducted as a cluster-randomized controlled trial among 1252 practices (clusters) with 2211 general practitioners in Denmark...
February 13, 2017: Trials
https://www.readbyqxmd.com/read/28192643/associations-between-substance-use-disorders-and-suicide-or-suicide-attempts-in-people-with-mental-illness-a-danish-nationwide-prospective-register-based-study-of-patients-diagnosed-with-schizophrenia-bipolar-disorder-unipolar-depression-or-personality-disorder
#10
Marie L D Østergaard, Merete Nordentoft, Carsten Hjorthøj
AIM: To estimate and test associations between substance use disorders (SUDs) and both completed suicides and suicide attempts in a population with severe mental illness. DESIGN: Register-based cohort study with adjusted Cox regression of substance use disorders as time-varying covariates. SETTING: Denmark. PARTICIPANTS: People born in Denmark since 1955 with a diagnosis of schizophrenia (n = 35,625), bipolar disorder (n = 9,279), depression (n = 72,530), or personality disorder (n = 63,958)...
February 13, 2017: Addiction
https://www.readbyqxmd.com/read/28187995/validity-of-peripheral-arterial-disease-diagnoses-in-the-danish-national-patient-registry
#11
A N Lasota, K Overvad, H H Eriksen, A Tjønneland, E B Schmidt, M-L M Grønholdt
OBJECTIVES/BACKGROUND: The objective was to validate the diagnoses of peripheral arterial disease (PAD) in the legs, obtained from national registers in Denmark. METHODS: In total, 1435 registered cases of PAD were identified in the Danish National Patient Registry among 57,053 middle aged participants from the Danish Diet, Cancer and Health cohort study. Validation was performed by reviewing all medical records using pre-specified criteria for a diagnosis of PAD...
February 7, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28186937/is-prolonged-sitting-at-work-associated-with-the-time-course-of-neck-shoulder-pain-a-prospective-study-in-danish-blue-collar-workers
#12
David M Hallman, Nidhi Gupta, Marina Heiden, Svend Erik Mathiassen, Mette Korshøj, Marie Birk Jørgensen, Andreas Holtermann
OBJECTIVES: This study aimed to determine the extent to which objectively measured sitting time at work is associated with the course of neck-shoulder pain across 1 year in blue-collar workers. METHODS: Data were analysed from 625 blue-collar workers in the Danish PHysical ACTivity cohort with Objective measurements (DPHACTO) cohort study (2012-2013). Objective data on sitting time were collected at baseline using accelerometry. Self-reported pain intensity (numeric rating scale 0-10) in the neck-shoulder region was registered for 1 year using repeated text messages (14 in total)...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28186614/decline-in-stillbirths-and-perinatal-mortality-after-implementation-of-a-more-aggressive-induction-policy-in-post-date-pregnancies-a-nationwide-register-study
#13
Anne R Zizzo, Ida Kirkegaard, Anja Pinborg, Niels Ulbjerg
INTRODUCTION: In 2011 the Danish national guidelines were changed towards a more aggressive induction and fetal surveillance policy from 1) induction of labor at gestational age (GA) of 42(+0) weeks and 2) no fetal surveillance after 40(+0) to 1) induction of labor between 41(+2) -41(+6) , 2) earlier induction at 41(+0) weeks in case of maternal age > 40 years or body mass index (BMI) > 35 kg/m(2) and 3) fetal surveillance at GA 41(+0) . MATERIAL AND METHODS: This national cohort study included all pregnancies that reached 41(+0) weeks of gestation from 2008 to 2014 (N=102 167)...
February 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28185095/in-utero-exposure-to-%C3%AE-2-adrenergic-receptor-agonist-and-attention-deficit-hyperactivity-disorder-in-children
#14
Hong Liang, Jianping Chen, Maohua Miao, Jakob Christensen, Søren Dalsgaard, Wei Yuan, Jiong Li
We aimed to examine the association between in utero exposure to β2AA and risk of attention-deficit/hyperactivity disorder (ADHD). We established a cohort of 672,265 children born from 1998 to 2008 in Denmark. Children were categorized as exposed if their mothers had redeemed a prescription of β2AA in pregnancy (from 30 days prior to conception until delivery). We identified children diagnosed with ADHD in the Danish National Hospital Register for the first time after his/her third birthday. Log-linear Poisson regression was used to estimate adjusted incidence rate ratio (aIRR) of ADHD...
February 9, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28183396/denheart-differences-in-physical-and-mental-health-across-cardiac-diagnoses-at-hospital-discharge
#15
Selina Kikkenborg Berg, Trine Bernholdt Rasmussen, Lars Thrysoee, Astrid Lauberg, Britt Borregaard, Anne Vinggaard Christensen, Ola Ekholm, Knud Juel, Jette Rolf Svanholm
OBJECTIVE: To describe: (i) differences in patient reported physical and mental health outcomes at hospital discharge between a) cardiac diagnostic groups and b) cardiac patients and a national representative reference population and to describe (ii) in-hospital predicting factors for patient reported outcomes. METHODS: A national cross-sectional survey combined with national register data. From April 2013 to April 2014 all patients (n=34,564) discharged or transferred from one of five Danish Heart Centres were invited to participate...
March 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28182624/socio-demographic-characteristics-of-danish-blood-donors
#16
Kristoffer Sølvsten Burgdorf, Jacob Simonsen, Anna Sundby, Klaus Rostgaard, Ole Birger Pedersen, Erik Sørensen, Kaspar René Nielsen, Mie Topholm Bruun, Morten Frisch, Gustaf Edgren, Christian Erikstrup, Henrik Hjalgrim, Henrik Ullum
BACKGROUND: Blood transfusion is an essential component of a modern healthcare system. Because knowledge about blood donor demography may inform the design of strategies for donor recruitment and retention, we used nationwide registers to characterize the entire population of blood donors in Denmark in 2010. METHODS: The study population comprised all Danes in the age range eligible for blood donation (N = 3,236,753) at the end of 2010. From the Scandinavian Donations and Transfusions (SCANDAT) register, we identified 174,523 persons who donated blood in Danish blood banks at least once in 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28181672/endometriosis-increases-the-risk-of-obstetrical-and-neonatal-complications
#17
Janne Foss Berlac, Dorthe Hartwell, Charlotte Wessel Skovlund, Jens Langhoff-Roos, Øjvind Lidegaard
INTRODUCTION: The objective was to assess obstetrical complications and neonatal outcomes in women with endometriosis as compared to women without endometriosis. MATERIAL AND METHODS: National cohort including all delivering women and their newborns in Denmark 1997-2014. Data were extracted from the Danish Health Register and the Medical Birth Register. Logistic regression analysis provided odds ratios (OR) with 95% confidence intervals (CI). Sub-analyses were made for primiparous women with a singleton pregnancy and for women with endometriosis who underwent gynecological surgery before pregnancy...
February 9, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28176979/risk-of-pneumonia-and-urinary-tract-infection-within-the-first-week-after-total-hip-arthroplasty-and-the-impact-on-survival
#18
Eva N Glassou, Torben B Hansen, Alma B Pedersen
BACKGROUND: Pneumonia and urinary tract infections (UTIs) increase morbidity and mortality. There is little epidemiological evidence from large population-based studies on risk factors for these infections and subsequent mortality in total hip arthroplasty (THA) patients. AIM: To examine the risk factors of postoperative pneumonia and UTI after THA and their impact on survival. PATIENTS AND METHODS: We used the Danish Hip Arthroplasty Register to identify THAs due to osteoarthritis registered from 2000 to 2013...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28176348/inflammatory-bowel-diseases-in-faroese-born-danish-residents-and-their-offspring-further-evidence-of-the-dominant-role-of-environmental-factors-in-ibd-development
#19
T Hammer, S N Lophaven, K R Nielsen, M von Euler-Chelpin, P Weihe, P Munkholm, J Burisch, E Lynge
BACKGROUND: The incidence of inflammatory bowel disease (IBD) is record high in the Faroe Islands, and many Faroese emigrate to Denmark, where the IBD incidence is considerably lower. AIM: To study the IBD incidence in first-, second- and third-generation immigrants from the Faroe Islands to Denmark to assess the extent to which the immigrants adopt the lower IBD incidence of their new home country. METHODS: Data on Faroese-born Danish residents and their children were retrieved from the Danish Central Population Register for 1980-2014...
February 8, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28168422/contact-allergy-to-preservatives-in-patients-with-occupational-contact-dermatitis-and-exposure-analysis-of-preservatives-in-registered-chemical-products-for-occupational-use
#20
Jakob Ferløv Schwensen, Ulrik Fischer Friis, Torkil Menné, Mari-Ann Flyvholm, Jeanne Duus Johansen
PURPOSE: The aim of the study is to investigate risk factors for sensitization to preservatives and to examine to which extent different preservatives are registered in chemical products for occupational use in Denmark. METHODS: A retrospective epidemiological observational analysis of data from a university hospital was conducted. All patients had occupational contact dermatitis and were consecutively patch tested with 11 preservatives from the European baseline series and extended patch test series during a 5-year period: 2009-2013...
February 6, 2017: International Archives of Occupational and Environmental Health
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