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https://www.readbyqxmd.com/read/28603465/spinal-cord-as-an-adjunct-to-brain-magnetic-resonance-imaging-in-defining-no-evidence-of-disease-activity-in-multiple-sclerosis
#1
Subhash Tummala, Tarun Singhal, Vinit V Oommen, Gloria Kim, Fariha Khalid, Brian C Healy, Rohit Bakshi
ACTIVITY AVAILABLE ONLINE: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: 1) Describe the concept of "no evidence of disease activity" in MS.2) Recognize the role of spinal cord imaging in routine monitoring of MS disease activity...
May 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28530525/cost-effectiveness-of-nivolumab-ipilimumab-combination-therapy-compared-with-monotherapy-for-first-line-treatment-of-metastatic-melanoma-in-the-united-states
#2
Anna Oh, Dang M Tran, Leann C McDowell, Dor Keyvani, Jay Andrew Barcelon, Oscar Merino, Leslie Wilson
BACKGROUND: The approval of new immunotherapies has dramatically changed the treatment landscape of metastatic melanoma. These survival gains come with trade-offs in side effects and costs, as well as important considerations for third-party payer systems, physicians, and patients. OBJECTIVE: To develop a Markov model to determine the cost-effectiveness of nivolumab, ipilimumab, and nivolumab-ipilimumab combination as firstline therapy in metastatic melanoma, while accounting for differential effectiveness in programmed death-ligand 1 (PD-L1) positive and negative patients...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28499122/emd-dwt-based-transform-domain-feature-reduction-approach-for-quantitative-multi-class-classification-of-breast-lesions
#3
Sharmin R Ara, Syed Khairul Bashar, Farzana Alam, Md Kamrul Hasan
Using a large set of ultrasound features does not necessarily ensure improved quantitative classification of breast tumors; rather, it often degrades the performance of a classifier. In this paper, we propose an effective feature reduction approach in the transform domain for improved multi-class classification of breast tumors. Feature transformation methods, such as empirical mode decomposition (EMD) and discrete wavelet transform (DWT), followed by a filter- or wrapper-based subset selection scheme are used to extract a set of non-redundant and more potential transform domain features through decorrelation of an optimally ordered sequence of N ultrasonic bi-modal (i...
September 2017: Ultrasonics
https://www.readbyqxmd.com/read/28152063/a-wavelet-based-technique-to-predict-treatment-outcome-for-major-depressive-disorder
#4
Wajid Mumtaz, Likun Xia, Mohd Azhar Mohd Yasin, Syed Saad Azhar Ali, Aamir Saeed Malik
Treatment management for Major Depressive Disorder (MDD) has been challenging. However, electroencephalogram (EEG)-based predictions of antidepressant's treatment outcome may help during antidepressant's selection and ultimately improve the quality of life for MDD patients. In this study, a machine learning (ML) method involving pretreatment EEG data was proposed to perform such predictions for Selective Serotonin Reuptake Inhibitor (SSRIs). For this purpose, the acquisition of experimental data involved 34 MDD patients and 30 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#5
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27884153/performance-evaluation-of-the-touchscreen-based-muse%C3%A2-auto-cd4-cd4-single-platform-system-for-cd4-t-cell-numeration-in-absolute-number-and-in-percentage-using-blood-samples-from-children-and-adult-patients-living-in-the-central-african-republic
#6
Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet, Laurent Bélec
BACKGROUND: The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in absolute number and in percentage was evaluated using Central African patients' samples compared against the reference EC IVD-qualified BD FACSCount (Becton-Dickinson, USA) flow cytometer. METHODS: EDTA-blood samples from 124 adults, 10 adolescents, 13 children and 3 infants were tested in parallel at 2 reference laboratories in Bangui...
November 25, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27343272/ovarian-hyperstimulation-syndrome-review-and-new-classification-criteria-for-reporting-in-clinical-trials
#7
P Humaidan, S M Nelson, P Devroey, C C Coddington, L B Schwartz, K Gordon, J L Frattarelli, B C Tarlatzis, H M Fatemi, P Lutjen, B J Stegmann
STUDY QUESTION: What is an objective approach that employs measurable and reproducible physiologic changes as the basis for the classification of ovarian hyperstimulation syndrome (OHSS) in order to facilitate more accurate reporting of incidence rates within and across clinical trials? SUMMARY ANSWER: The OHSS flow diagram is an objective approach that will facilitate consistent capture, classification and reporting of OHSS within and across clinical trials. WHAT IS KNOWN ALREADY: OHSS is a potentially life-threatening iatrogenic complication of the early luteal phase and/or early pregnancy after ovulation induction (OI) or ovarian stimulation (OS)...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/26971593/the-preclinical-and-clinical-effects-of-vilazodone-for-the-treatment-of-major-depressive-disorder
#8
REVIEW
Zeyad T Sahli, Pradeep Banerjee, Frank I Tarazi
INTRODUCTION: Major depressive disorder (MDD) is the leading cause of disability worldwide, and according to the STAR*D trial, only 33% of patients with MDD responded to initial drug therapy. Augmentation of the leading class of antidepressant treatment, selective serotonin reuptake inhibitors (SSRIs), with the 5-HT1A receptor agonist buspirone has been shown to be effective in treating patients that do not respond to initial SSRI therapy. This suggests that newer treatments may improve the clinical picture of MDD...
2016: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/26922239/acute-toxicity-in-comprehensive-head-and-neck-radiation-for-nasopharynx-and-paranasal-sinus-cancers-cohort-comparison-of-3d-conformal-proton-therapy-and-intensity-modulated-radiation-therapy
#9
Mark W McDonald, Yuan Liu, Michael G Moore, Peter A S Johnstone
BACKGROUND: To evaluate acute toxicity endpoints in a cohort of patients receiving head and neck radiation with proton therapy or intensity modulated radiation therapy (IMRT). METHODS: Forty patients received comprehensive head and neck radiation including bilateral cervical nodal radiation, given with or without chemotherapy, for tumors of the nasopharynx, nasal cavity or paranasal sinuses, any T stage, N0-2. Fourteen received comprehensive treatment with proton therapy, and 26 were treated with IMRT, either comprehensively or matched to proton therapy delivered to the primary tumor site...
February 27, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/26472256/aeromonas-chitinase-degrades-chironomid-egg-masses
#10
Sivan Laviad, Amnon Golan, Tamar Shaked, Dalit Vaizel-Ohayon, Malka Halpern, Elah Pick
Chironomids are freshwater insects that undergo a complete metamorphosis of four life stages. Chironomid egg masses can be degraded by Vibrio cholerae and some Aeromonas species. Egg mass degradation by V. cholerae requires haemagglutinin protease activity. Our aim was to identify the egg mass degrading (EMD) factor secreted by Aeromonas dhkanesis 3K1C15. Following the hypothesis that the EMD factor of A. dhkanesis is also a protease, secreted proteases were screened, but none of them proved to have the same properties as the EMD factor...
February 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/26028803/shape-index-distribution-based-local-surface-complexity-applied-to-the-human-cortex
#11
Sun Hyung Kim, Vladimir Fonov, D Louis Collins, Guido Gerig, Martin A Styner
The quantification of local surface complexity in the human cortex has shown to be of interest in investigating population differences as well as developmental changes in neurodegenerative or neurodevelopment diseases. We propose a novel assessment method that represents local complexity as the difference between the observed distributions of local surface topology to its best-fit basic topology model within a given local neighborhood. This distribution difference is estimated via Earth Move Distance (EMD) over the histogram within the local neighborhood of the surface topology quantified via the Shape Index (SI) measure...
2015: Proceedings of SPIE
https://www.readbyqxmd.com/read/26005166/early-neurologically-focused-follow-up-after-cardiac-arrest-improves-quality-of-life-at-one-year-a-randomised-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Véronique R M Moulaert, Caroline M van Heugten, Bjorn Winkens, Wilbert G M Bakx, Marc C F T M de Krom, Ton P M Gorgels, Derick T Wade, Jeanine A Verbunt
BACKGROUND: Survivors of a cardiac arrest frequently have cognitive and emotional problems and their quality of life is at risk. We developed a brief nursing intervention to detect cognitive and emotional problems, provide information and support, promote self-management, and refer them to specialised care if necessary. This study examined its effectiveness. METHODS: Multicentre randomised controlled trial with measurements at two weeks, three months and twelve months after cardiac arrest...
August 15, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25871328/quicksilver-a-phase-ii-study-using-magnetic-resonance-imaging-criteria-to-identify-good-prognosis-rectal-cancer-patients-eligible-for-primary-surgery
#13
(no author information available yet)
BACKGROUND: Recently, two nonrandomized, prospective cohort studies used magnetic resonance imaging (MRI) to assess the circumferential resection margin to identify "good prognosis" rectal tumors eligible for primary surgery and have reported favorable outcomes. OBJECTIVE: The objective of this project was to conduct a Phase II trial to assess the safety and feasibility of MRI criteria to identify "good prognosis" rectal tumors eligible for primary surgery in the North American setting...
April 14, 2015: JMIR Research Protocols
https://www.readbyqxmd.com/read/25454731/abnormal-proliferation-and-spontaneous-differentiation-of-myoblasts-from-a-symptomatic-female-carrier-of-x-linked-emery-dreifuss-muscular-dystrophy
#14
Peter Meinke, Peter Schneiderat, Vlastimil Srsen, Nadia Korfali, Phú Lê Thành, Graeme J M Cowan, David R Cavanagh, Manfred Wehnert, Eric C Schirmer, Maggie C Walter
Emery-Dreifuss muscular dystrophy (EDMD) is a neuromuscular disease characterized by early contractures, slowly progressive muscular weakness and life-threatening cardiac arrhythmia that can develop into cardiomyopathy. In X-linked EDMD (EDMD1), female carriers are usually unaffected. Here we present a clinical description and in vitro characterization of a mildly affected EDMD1 female carrying the heterozygous EMD mutation c.174_175delTT; p.Y59* that yields loss of protein. Muscle tissue sections and cultured patient myoblasts exhibited a mixed population of emerin-positive and -negative cells; thus uneven X-inactivation was excluded as causative...
February 2015: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/25403767/nematode-eel-parasite-found-inside-acanthocephalan-cysts-a-trojan-horse-strategy
#15
Sebastian Emde, Sonja Rueckert, Judith Kochmann, Klaus Knopf, Bernd Sures, Sven Klimpel
BACKGROUND: The invasive eel parasite Anguillicoloides crassus (syn. Anguillicola crassus) is considered one of the major causes for the decline of the European eel (Anguilla anguilla) panmictic population. It impairs the swim bladder function and reduces swimming performance of its host. The life cycle of this parasite involves different intermediate and paratenic hosts. Despite an efficient immune system of the paratenic fish hosts acting against infections with A. crassus, levels of parasitized eels remain high in European river systems...
2014: Parasites & Vectors
https://www.readbyqxmd.com/read/25333069/disease-variants-in-genomes-of-44-centenarians
#16
Yun Freudenberg-Hua, Jan Freudenberg, Vladimir Vacic, Avinash Abhyankar, Anne-Katrin Emde, Danny Ben-Avraham, Nir Barzilai, Dayna Oschwald, Erika Christen, Jeremy Koppel, Blaine Greenwald, Robert B Darnell, Soren Germer, Gil Atzmon, Peter Davies
To identify previously reported disease mutations that are compatible with extraordinary longevity, we screened the coding regions of the genomes of 44 Ashkenazi Jewish centenarians. Individual genome sequences were generated with 30× coverage on the Illumina HiSeq 2000 and single-nucleotide variants were called with the genome analysis toolkit (GATK). We identified 130 coding variants that were annotated as "pathogenic" or "likely pathogenic" based on the ClinVar database and that are infrequent in the general population...
September 2014: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/24520167/bringing-dead-proteins-back-to-life
#17
COMMENT
Brandon A Wustman, John W Steele, Eric R Sjoberg, Anthony C Stevens
A small molecule called EMD 57033 can repair motor proteins that have stopped working as a result of stress.
2014: ELife
https://www.readbyqxmd.com/read/24246508/short-and-long-term-effects-of-supervised-versus-unsupervised-exercise-training-on-health-related-quality-of-life-and-functional-outcomes-following-lung-cancer-surgery-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Barbara Cristina Brocki, Jane Andreasen, Lene Rodkjaer Nielsen, Vytautas Nekrasas, Anders Gorst-Rasmussen, Elisabeth Westerdahl
OBJECTIVE: Surgical resection enhances long-term survival after lung cancer, but survivors face functional deficits and report on poor quality of life long time after surgery. This study evaluated short and long-term effects of supervised group exercise training on health-related quality of life and physical performance in patients, who were radically operated for lung cancer. METHODS: A randomized, assessor-blinded, controlled trial was performed on 78 patients undergoing lung cancer surgery...
January 2014: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/24028558/which-emergency-medical-dispatch-codes-predict-high-prehospital-nontransport-rates-in-an-urban-community
#19
Evan M Hodell, Karl A Sporer, John F Brown
BACKGROUND: The Medical Priority Dispatch System (MPDS) is a commonly used computer-based emergency medical dispatch (EMD) system that is widely used to prioritize 9-1-1 calls and optimize resource allocation. There are five major priority classes used to dispatch 9-1-1 calls in the San Francisco System; Alpha codes are the lowest priority (lowest expected acuity) and Echo are the highest priority. OBJECTIVE: We sought to determine which MPDS dispatch codes are associated with high prehospital nontransport rates (NTRs)...
January 2014: Prehospital Emergency Care
https://www.readbyqxmd.com/read/23650518/the-complexity-of-standing-postural-control-in-older-adults-a-modified-detrended-fluctuation-analysis-based-upon-the-empirical-mode-decomposition-algorithm
#20
Junhong Zhou, Brad Manor, Dongdong Liu, Kun Hu, Jue Zhang, Jing Fang
Human aging into senescence diminishes the capacity of the postural control system to adapt to the stressors of everyday life. Diminished adaptive capacity may be reflected by a loss of the fractal-like, multiscale complexity within the dynamics of standing postural sway (i.e., center-of-pressure, COP). We therefore studied the relationship between COP complexity and adaptive capacity in 22 older and 22 younger healthy adults. COP magnitude dynamics were assessed from raw data during quiet standing with eyes open and closed, and complexity was quantified with a new technique termed empirical mode decomposition embedded detrended fluctuation analysis (EMD-DFA)...
2013: PloS One
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