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https://www.readbyqxmd.com/read/29161745/resting-autonomic-function-in-active-and-insufficiently-active-people-living-with-hiv
#1
Norberto Quiles, Carol Garber, Joseph Ciccolo
Autonomic dysfunction appears to be prevalent in people living with HIV/AIDS (PLWHA). However, there are limited data on the resting autonomic responses to exercise in active and insufficiently active PLWHA. We aimed to determine whether active PLWHA have better autonomic responses compared with insufficiently active PLWHA. Active PLWHA receiving anti-retroviral therapy (n=13) and insufficiently active PLWHA (n=10) were recruited. A 10-min recording of the supine electrocardiogram was taken. Resting heart rate variability was analyzed from this electrocardiogram...
November 21, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29154044/modulating-host-immune-responses-to-fight-invasive-fungal-infections
#2
REVIEW
James E Scriven, Mark W Tenforde, Stuart M Levitz, Joseph N Jarvis
Modulation of host immunity in invasive fungal infection is an appealing but as yet mostly elusive treatment strategy. Animal studies in invasive candidiasis and aspergillosis have demonstrated beneficial effects of colony stimulating factors, interferon-gamma and monoclonal antibodies. More recent studies transfusing leukocytes pre-loaded with lipophilic anti-fungal drugs, or modulated T-cells, along with novel vaccination strategies show great promise. The translation of immune therapies into clinical studies has been limited to date but this is changing and the results of new Candida vaccine trials are eagerly awaited...
November 15, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29143162/anti-retroviral-status-and-hiv-transmission-risk-behaviors-are-associated-with-age-time-since-diagnosis-and-psychosocial-factors-among-women-living-with-hiv-aids-enrolling-in-the-willow-intervention-at-community-based-organizations
#3
Weston O Williams, Tanesha Griffin, Gary Uhl
Safe sexual behaviors and anti-retroviral use help prevent HIV transmission. In this cross-sectional study, we assessed correlates of anti-retroviral (ART) status and transmission risk (a constructed variable) among a convenience sample of n = 1041 HIV-positive women (pre-intervention) enrolled in an evidence-based intervention at four CBOs. Multinomial logistic regression models were used. Younger women and those diagnosed with HIV in the last 5 years more often reported that they had not been prescribed ART...
November 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29141626/health-related-quality-of-life-of-hiv-aids-patients-on-highly-active-anti-retroviral-therapy-at-a-university-referral-hospital-in-ethiopia
#4
Abdrrahman Shemsu Surur, Fitsum Sebsibe Teni, Wondwessen Wale, Yihenew Ayalew, Betel Tesfaye
BACKGROUND: Highly active antiretroviral therapy improves the longevity of patients living with HIV/AIDS. We conducted the study in order to assess health related quality of life of HIV/AIDS patients and the association of socio-demographic and disease related variables with health related quality of life. METHODS: Health facility based cross-sectional study among 400 HIV/AIDS patients taking highly active anti-retroviral therapy from Gondar University referral hospital was conducted...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29140874/hiv-and-age-do-not-synergistically-affect-age-related-t-cell-markers
#5
Shelli Farhadian, Emilie Jalbert, Yanhong Deng, Matthew Bidwell Goetz, Lesley S Park, Amy Justice, Robert Dubrow, Brinda Emu
INTRODUCTION: Despite major progress in controlling HIV disease through anti-retroviral therapy (ART), changes in immune phenotype and function persist in individuals with chronic HIV, raising questions about accelerated aging of the immune system. METHODS: We conducted a cross sectional study (2005-2007) of HIV-infected (n=111) and uninfected (n=114) males from the Veterans Aging Cohort Study. All HIV-infected subjects were on ART with VL<400 copies/mL for at least three years...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135650/pathways-from-hiv-related-stigma-to-antiretroviral-therapy-measures-in-the-hiv-care-cascade-for-women-living-with-hiv-in-canada
#6
Carmen H Logie, Ashley Lacombe-Duncan, Ying Wang, Angela Kaida, Tracey Conway, Kath Webster, Alexandra de Pokomandy, Mona R Loutfy
BACKGROUND: Associations between HIV-related stigma and reduced anti-retroviral (ART) adherence are widely established, yet the mechanisms accounting for this relationship are underexplored. There has been less attention to HIV-related stigma and its associations with ART initiation and current ART use. We examined pathways from HIV-related stigma to ART initiation, current ART use, and ART adherence among women living with HIV in Canada. METHODS: We utilized baseline survey data from a national cohort of women living with HIV in Canada (n=1425)...
November 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29127578/comparative-outcomes-of-bariatric-surgery-in-patients-with-and-without-human-immunodeficiency-virus
#7
Gautam Sharma, Andrew T Strong, Mena Boules, Chao Tu, Samuel Szomstein, Raul Rosenthal, John Rodriguez, Alan J Taege, Matthew Kroh
BACKGROUND: Paradoxically, advances in anti-retroviral therapy that has increased survival for patients with human immunodeficiency virus (HIV) have resulted in greater numbers of HIV+ patients developing other chronic diseases, including obesity. Little comparative literature exists detailing perioperative or metabolic outcomes of bariatric surgery in the HIV+ population compared to HIV negative (HIV-) controls. METHODS: This is a retrospective case-control study with both HIV+ (case) and HIV- control patients...
November 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29118747/emerging-targets-for-developing-t-cell-mediated-vaccines-for-human-immunodeficiency-virus-hiv-1
#8
REVIEW
Danushka K Wijesundara, Charani Ranasinghe, Branka Grubor-Bauk, Eric J Gowans
Human immunodeficiency virus (HIV)-1 has infected >75 million individuals globally, and, according to the UN, is responsible for ~2.1 million new infections and 1.1 million deaths each year. Currently, there are ~37 million individuals with HIV infection and the epidemic has already resulted in 35 million deaths. Despite the advances of anti-retroviral therapy (ART), a cost-effective vaccine remains the best long-term solution to end the HIV-1 epidemic especially given that the vast majority of infected individuals live in poor socio-economic regions of the world such as Sub-Saharan Africa which limits their accessibility to ART...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29112069/neuropsychological-performance-in-african-children-with-hiv-enrolled-in-a-multi-site-anti-retroviral-clinical-trial
#9
Michael J Boivin, Linda Barlow-Mosha, Miriam Chernoff, Barbara Laughton, Bonnie Zimmer, Celeste Joyce, Mutsa Bwakura-Dangarembizi, Mmule Ratswana, Nasreen Abrahams, Lee Fairlie, Hermien Gous, Portia Kamthunzi, Katie McCarthy, Itziar Familiar-Lopez, Patrick Jean-Phillippe, Joan Coetzee, Avy Violari, Mark Cotton, Paul Palumbo
OBJECTIVE & DESIGN: Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries. METHODS: IMPAACT P1060 compared Nevirapine (NVP) versus Lopinavir/Ritonavir (LPVr)-based ART in HIV-infected children 6 to 35 months of age...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29093251/-magnetic-resonance-imaging-features-of-cryptococcus-infection-in-central-nervous-system-in-patients-with-aids
#10
Chuanjun Xu, Zhiliang Hu, Hongxia Wei, Yongfeng Yang, Chao Du, Jianping Gu
To investigate the magnetic resonance imaging (MRI) features of Cryptococcus infection in central nervous system patients with acquired immune deficiency syndrome (AIDS).
 Methods: The retrospective study on magnetic resonance imaging (MRI) and clinical data of cryptococcal meningitis (CM) was carried out between July 2011 and March 2017. These patients had not received anti-retroviral treatment. Patients with other specific or suspicious diseases in the central nervous system were not included in the analysis...
October 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29093081/analysis-of-select-hsv-1-proteins-for-restriction-of-human-immunodeficiency-virus-type-1-the-hsv-1-gm-protein-potently-restricts-hiv-1-by-preventing-the-intracellular-transport-and-processing-of-env-gp160
#11
Sachith Polpitiya Arachchige, Wyatt Henke, Ankita Pramanik, Maria Kalamvoki, Edward B Stephens
Proteins encoded by viruses that impair or shutdown specific host cell functions during replication can be used as probes to identify potential proteins/pathways used in the replication of viruses from other families. We screened nine proteins from herpes simplex virus type 1 (HSV-1) for the ability to enhance or restrict human immunodeficiency virus type 1 (HIV-1) replication. We show that several HSV-1 proteins (glycoprotein M (gM), US3 and UL24) potently restricted the replication of HIV-1. Unlike UL24 and US3, which reduced viral protein synthesis, we observed that gM restriction of HIV-1 occurred through interference of the processing and transport of gp160, resulting in a significantly reduced level of mature gp120/gp41 released from cells...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29068840/on-the-analysis-of-case-control-studies-in-cluster-correlated-data-settings
#12
Sebastien Haneuse, Claudia Rivera
In resource-limited settings, long-term evaluation of national anti-retroviral treatment (ART) programs often relies on aggregated data, the analysis of which may be subject to ecological bias. As researchers and policy-makers consider evaluating individual-level outcomes such as treatment adherence or mortality, the well-known case-control design is appealing in that it provides efficiency gains over random sampling. In the context that motivates this paper, valid estimation and inference requires acknowledging any clustering although, to our knowledge, no statistical methods have been published for the analysis of case-control data for which the underlying population exhibits clustering...
October 24, 2017: Epidemiology
https://www.readbyqxmd.com/read/29048546/housing-psychosocial-and-adherence-counseling-among-hiv-persons-in-ghana
#13
Eric Y Tenkorang, Adobea Y Owusu, Amos K Laar, Eric H Yeboah
As part of providing comprehensive HIV/AIDS services, the Ghana National AIDS Control Programme (NACP) and Ministry of Health recommend that Persons Living with HIV/AIDS (PLWHAs) receive psychosocial support and follow-up visits that ensure medical and drug adherence assistance. The successful implementation of these support services requires patients to have stable and quality housing, yet studies that examine associations between housing, psychosocial support, and adherence counseling among PLWHAs in Ghana and sub-Saharan Africa are limited...
October 18, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29034998/the-albumin-bilirubin-grade-uncovers-the-prognostic-relationship-between-hepatic-reserve-and-immune-dysfunction-in-hiv-associated-hepatocellular-carcinoma
#14
D J Pinato, R Sharma, C Citti, H Platt, M Ventura-Cots, E Allara, T-Y Chen, A Dalla Pria, M Jain, B Mínguez, L Kikuchi, E Kaufman West, M Merli, D E Kaplan, H Hasson, K Marks, M Nelson, M Núñez, A Aytaman, M Bower, N Bräu
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of liver-related mortality in people living with HIV, where co-infection with hepatotropic viruses accelerates the course of chronic liver disease. AIM: To evaluate whether the albumin-bilirubin (ALBI) grade, a more accurate marker of liver dysfunction in HCC, might identify patients with progressive liver dysfunction in the context of HIV/hepatitis co-infection. METHODS: Using uni- and multi-variable analyses, we studied the albumin-bilirubin grade as a predictor of overall survival (OS) in a large, multi-center cohort of patients with HIV-associated HCC recruited from 44 centres in 9 countries within the Liver Cancer in HIV study group...
October 16, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29026396/willingness-by-people-living-with-hiv-aids-to-utilize-hiv-services-provided-by-village-health-team-workers-in-kalungu-district-central-uganda
#15
Mutaawe Lubogo, Ronald Anguzu, Humphrey Wanzira, Irene Namugwanya, Oliver Namuddu, Denis Ssali, Sylivia Nanyonga, Josephine Ssentongo, Janet Seeley
BACKGROUND: Less than one quarter of people in need have access to HIV services in Uganda. This study assessed willingness of people living with HIV/AIDS (PLWHAs) to utilize HIV services provided by Village Health Teams (VHTs) in Kalungu district, central Uganda. METHODS: A cross-sectional study conducted in two health facilities providing anti-retroviral therapy enrolled 312 PLWHAs. Pre-tested semi-structured questionnaires were administered to participants at household level...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29022646/low-skeletal-mass-is-an-important-predictor-of-osteoporosis-in-hiv-infected-men-in-india
#16
Deep Dutta, Meha Sharma, Rahul Bansal, Neera Sharma, Umesh Chandra Garga, Atul Anand, Kumar Gaurav
INTRODUCTION: This study evaluated prevalence and predictors of osteoporosis and sarcopenia in men with HIV. MATERIAL AND METHODS: 220 men with HIV were screened, of which 115 men, 30-50 years-age, having at least 1-year follow-up, underwent hormonal and DEXA analysis. 40 controls were also evaluated. RESULTS: Males with HIV had significantly lower BMD and Z-scores at all sites. Osteoporosis was diagnosed in 64.35%; commonest site being radius total (49...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29021399/modelling-of-anti-latency-treatment-in-hiv-what-is-the-optimal-duration-of-anti-retroviral-free-hiv-remission
#17
Deborah Cromer, Mykola Pinkevych, Thomas A Rasmussen, Sharon R Lewin, Stephen J Kent, Miles P Davenport
A number of treatment strategies are currently being developed to promote anti-retroviral free HIV cure or remission. While complete elimination of the HIV reservoir would prevent recurrence of infection, it is not clear how different remission lengths would affect viral rebound and transmission. In this work we use a stochastic model to show that a treatment that achieves a one-year average time to viral remission will still lead to nearly a quarter of subjects experiencing viral rebound within the first three months...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29017426/investigations-on-the-influence-of-zidovudine-in-the-pharmacokinetics-of-isoniazid-and-its-hepatotoxic-metabolites-in-rats
#18
Raghu Ramanathan, Karthikeyan Sivanesan
The HIV-infected patients are co-infected with many bacterial infections in which tuberculosis is most common found worldwide. These patients are often administered with combined therapy of anti-retroviral and anti-tubercular drugs which leads to several complications including hepatotoxicity or adverse drug interactions. The drug-drug interactions between the anti-retroviral and anti-tubercular drugs are not clearly defined and hence, this study was conducted to evaluate the pharmacokinetic drug-drug interactions of Zidovudine (AZT) with Isoniazid (INH) and its hepatotoxic metabolites...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28993911/identifying-the-intersection-of-alcohol-adherence-and-sex-in-hiv-positive-men-on-art-treatment-in-india-using-an-adapted-timeline-followback-procedure
#19
Jean J Schensul, Toan Ha, Stephen Schensul, Avina Sarna, Kendall Bryant
People living with HIV (PLHIV) on anti-retroviral treatment (ART) who drink are less adherent and more likely to engage in unprotected sex but the connections among these events are correlational. Using an adapted Timeline Follow-Back (A-TLFB) procedure, this paper examines the day by day interface of alcohol, medication adherence and sex to provide a fine grained understanding of how multiple behavioral risks coincide in time and space, explores concordance/discordance of measures with survey data and identifies potential recall bias...
November 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28988399/control-of-hiv-infection-by-ifn-%C3%AE-implications-for-latency-and-a-cure
#20
REVIEW
Nollaig M Bourke, Silvia Napoletano, Ciaran Bannan, Suaad Ahmed, Colm Bergin, Áine McKnight, Nigel J Stevenson
Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence suggests that type I IFNs, in particular IFN-α, play a pivotal role in limiting acute HIV infection. Highly active anti-retroviral treatment reduces viral load and increases life expectancy in HIV positive patients; however, it fails to fully eliminate latent HIV reservoirs. To revisit HIV as a curable disease, this article reviews a body of literature that highlights type I IFNs as mediators in the control of HIV infection, with particular focus on the anti-HIV restriction factors induced and/or activated by IFN-α...
October 7, 2017: Cellular and Molecular Life Sciences: CMLS
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