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occult choriocarcinoma

Jesse L Cox, Geoffrey A Talmon, Scott A Koepsell
Identification of choriocarcinoma within a germ cell tumor can have major implications for the subsequent staging and treatment of testicular neoplasms. Immunoperoxidase staining greatly enhances the speed and sensitivity of identifying occult, though clinically significant, tumor components. In mixed germ cell tumors, staining for beta-human chorionic gonadotropin (β-hCG) has been historically used to assess for the presence and burden of choriocarcinoma. However, current β-hCG stains produce variable, intense staining of trophoblastic elements and surrounding tissues, clouding the assessment of true-positive staining...
2016: Disease Markers
John Aranake-Chrisinger, Phyllis C Huettner, Andrea R Hagemann, John D Pfeifer
Gestational trophoblastic tumors can be difficult to distinguish from nongestational neoplasms. Somatic and germ cell tumors can mimic gestational choriocarcinoma, and epithelioid trophoblastic tumor (ETT) is known for its histologic, and sometimes clinical, resemblance to squamous cell carcinoma. Short tandem repeat (STR) analysis can separate gestational from nongestational neoplasms and can provide useful information about the type of causative conceptus. We present a series of cases which demonstrate the utility of STR analysis in the evaluation of gestational choriocarcinoma, epithelioid trophoblastic tumor, and their mimics...
June 2016: Human Pathology
Girish D Bakhshi, Ashok D Borisa, Ajay H Bhandarwar, Mukund B Tayade, Rajesh B Yadav, Yogesh R Jadhav
Choricarcinoma is a beta human chorionic gonadotrophin secreting neoplasm pertinent to uterus and pregnancy mostly. It occurs primarily in gonads but rarely in extragonadal sites. Primary hepatic choriocarcinoma is an extremely rare tumor. Most of the reported cases are seen in infants representing metastasis from an occult placental choriocarcinoma. Till date, only 7 cases of primary hepatic choriocarcinoma in adults have been reported in literature. We present a case of a 40-yearold male presenting as haemoperitoneum due to ruptured hepatic tumor...
May 29, 2012: Clinics and Practice
Michael J Lee, Adam P Vogt, Wayland Hsiao, Adeboye O Osunkoya
CDX-2 is a caudal-type homeobox gene, encoding a transcription factor that plays an important role in proliferation and differentiation of intestinal epithelial cells. The utility of antibodies to CDX2 in the identification of adenocarcinomas of the gastrointestinal tract, particularly colorectal adenocarcinomas, in both primary and metastatic settings is well established. It is well-known that patients with testicular tumors may occasionally lack an obvious palpable mass. However, the expression of CDX2 in malignant germ cell tumors of the testes which have metastatic potential has not been previously studied in a large series...
December 2012: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Armita Bahrami, Jae Y Ro, Alberto G Ayala
CONTEXT: More than 90% of testicular neoplasms originate from germ cells. Testicular germ cell tumors (GCTs) are a heterogeneous group of neoplasms with diverse histopathology and clinical behavior. OBJECTIVE: To help the readers distinguish various subtypes of GCTs, to highlight the clinical manifestations and pathologic features of these tumors, and to review several newly developed immunohistochemical markers for GCTs. DATA SOURCES: Review of the pertinent literature and our experience...
August 2007: Archives of Pathology & Laboratory Medicine
M E Couce, R Medina-Flores, M Wong, C T Chu
No abstract text is available yet for this article.
May 2007: Histopathology
C-Y Huang, C-A Chen, C-Y Hsieh, W-F Cheng
Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and, less frequently, to the brain. One rare case of metastatic cerebral choriocarcinoma with initial presentation of intracerebral hemorrhage is reported. A 40-year-old woman initially presented sudden onset of headache. Intracerebral hemorrhage resulting from ruptured pseudoaneurysm was suspected. Emergent surgery with excision of the pseudoaneurysms was performed. Metastatic choriocarcinoma was accidentally found with positive immunohistochemical staining of cytokeratin and beta subunit of human chorionic gonadotropin (beta-HCG)...
September 2007: International Journal of Gynecological Cancer
Patrick O Emanuel, Pamela D Unger, David E Burstein
p63 is a novel transcription factor-encoding gene with sequence homology to p53. p63 proteins have epithelial stem-cell regulatory functions and play a critical role in tissue development. Study of p63 expression in testicular germ cell tumors has been limited. Thirty-four archival cases of testicular germ cell neoplasia were examined and stained with monoclonal anti-p63 antibody 4A4 using standard methods. Included were 19 seminomas, 1 pure teratoma, 3 pure embryonal carcinomas, 1 pure yolk sac tumor, and 10 mixed germ cell tumors...
October 2006: Annals of Diagnostic Pathology
T Michael Numnum, Charles A Leath, J Michael Straughn, Michael G Conner, Mack N Barnes
BACKGROUND: Positron emission tomography (PET) is commonly used to detect occult or recurrent malignancy, including tumors of the female genital tract. Recently, there have been reports of PET scans used in patients with Gestational Trophoblastic Disease (GTD). CASE: A 22-year-old female presented with vaginal bleeding and elevated beta-hCG 7 months after a spontaneous vaginal delivery of a healthy infant. She had a history of molar pregnancy and persistent GTD requiring multi-agent chemotherapy...
May 2005: Gynecologic Oncology
B Taback, A D Chan, C T Kuo, P J Bostick, H J Wang, A E Giuliano, D S Hoon
Currently, molecular markers offer the unique opportunity to identify occult metastasis in early stage cancer patients not otherwise detected with conventional staging techniques. To date, well-characterized molecular tumor markers to detect occult breast cancer cells in blood are limited. Because breast tumors are heterogeneous in tumor marker expression, we developed a "multimarker" reverse transcription-PCR assay combined with the highly sensitive electrochemiluminescence automated detection system. Breast cancer cell lines (n = 7), primary breast tumors (n = 25), and blood from normal donors (n = 40) and breast cancer patients [n = 65; American Joint Committee on Cancer (AJCC) stages I-IV] were assessed for four mRNA tumor markers: beta-human chorionic gonadotropin (beta-hCG), oncogene receptor (c-Met), beta 1-->4-N-acetylgalactosaminyl-transferase, and a tumor-associated antigen (MAGE-A3)...
December 15, 2001: Cancer Research
E López Alcina, M Rodrígo Aliaga, J M Martínez Jabaloyas, A Arlandis Guzmán, J Del Pino Porres, F Jiménez Cruz
Extragonadal germ cells tumors can arise primarily in the retroperitoneum. It has been suggested that these neoplasms might be metastasis from an occult testicular lesion which would have regressed later. We report our experience with seven retroperitoneal germ cell tumors without testicular involvement. The most frequent symptoms were lumbar or abdominal pain and paraneoplastic syndrome. Abdominal palpable mass was noticeable in 85% of patients. We point out the computerized tomography and echography as the most sensitive exploration for diagnosis...
November 1997: Actas Urologicas Españolas
A E Andreitchouk, O Takahashi, H Kodama, M Morita, T Sankawa, K Saito, K Enomoto, T Tanaka
We present a case of gestational choriocarcinoma that developed in a pregnant woman with metastases to her baby. In this case, severe anemia and hepatomegaly of the baby were noticed after delivery. Despite intensive treatments, the tumor progressed rapidly, and the baby died at the age of 38 days. Accurate diagnosis was made after autopsy. When the baby's mother visited our hospital again at 4 months postpartum, there were widespread multiple metastases to her lungs and liver. We want to emphasize that if a neonate or infant has anemia and/or hepatomegaly, it is necessary to be aware of the possibility of infantile choriocarcinoma with the presence of an occult tumor in the mother and to examine the mother's and infant's hCG levels immediately...
December 1996: Journal of Obstetrics and Gynaecology Research
A Houlgatte, P Berlizot, J Merrer, J L Sarrazin, D Hauteville, P Houdelette
In the absence of palpable testicular tumor one often retains the primitive character of an extragonadal germ-cell tumor with retroperitoneal localization. This motion must be reconsidered in front of the occasionally late discovery of the scrotal origin of those lesions. The usefulness of testicular sonography in the revelation of infra clinical lesions is now perfectly well admitted. Concurrently, testicular biopsies can provide the notion of carcinoma in situ and its links with the retroperitoneal germ-cell tumor must be indicated precisely...
August 1996: Progrès en Urologie
J Gómez Parada, M Puyol Pallas
OBJECTIVES: A case of impalpable primary testicular tumor or burned out testicular tumor is described, with special reference to its unusual form of presentation and histopathological characteristics. The rarity of this tumor type and the difficulties encountered in making the differential diagnosis prompted us to report on this case. METHODS/RESULTS: A case of impalpable primary testicular tumor is described in a patient with normal tests on physical examination, who had consulted for progressive respiratory failure from pulmonary metastasis...
July 1996: Archivos Españoles de Urología
S N Kim, J G Chi, Y W Kim, E S Dong, H Y Shin, H S Ahn, C W Kim
Neonatal choriocarcinoma associated with a seemingly normal gestation is rare. A total of 20 cases of either primary or metastatic choriocarcinoma in infancy have been reported until 1992. We report an additional case of a huge choriocarcinoma of the liver in a 2-month-old boy, who died of tumor hemorrhage. This baby was born to a 19-year-old unmarried mother. The placenta was thought to be normal and was not examined histologically. The liver mass was first noted 2 weeks after birth, and he was admitted because of poor feeding and pallor...
November 1993: Pediatric Pathology
J L Pennacchio, R Pugatch, W G Doos, W K Hong
We report on a patient who presented with a metastatic germ cell tumor and had a normal testicular examination. A complete response ensued following combination chemotherapy. A sequential germ cell tumor of the testes developed 20 months after the chemotherapy was stopped. This occurrence of clinically evident disease in the testes is consistent with either a second primary tumor or with recurrent disease from an occult focus not eradicated by prior systemic chemotherapy. Our case is compared to other cases of sequential germ cell tumors reported in the literature...
December 1981: Journal of Urology
Y Sawaki, Y Nishiyama, M Ito, S Hayakawa, H Imaizumi, Y Nose, Y Sugiyama
We developed a highly sensitive EIA for determination of SP1. The detection limit was 5ng/ml, and the correlation of EIA and RIA was extremely good (SAWAKI et al., 1980). Using this method, we found that SP1 was detected even in the serum at 12 days of ovulation. The concentration of SP1 in cord blood was on average 127ng/ml (24-540ng/ml). SP1 in newborn serum was 126ng/ml (22-355ng/ml) in 1st, and almost undetected in 4th day. SP1 in urine was 9.7ng/ml in the 5th week of pregnancy, 1,210ng/ml at peak in the 32th week, and in after delivery was 439ng/ml in 1st day and afterwards descended to 6ng/ml in 8th day...
January 1982: Nihon Sanka Fujinka Gakkai Zasshi
H S Glazer, J K Lee, G L Melson, B L McClennan
Testicular sonograms were performed in four patients with pathologically proven metastatic neoplasms but a normal physical examination of the scrotum. An abnormal echo texture was seen in all cases: focal hypoechoic nodule (about 1 cm) in two, diffusely hypoechoic in one, and mixed diffuse/focal abnormality in one. Correct sonographic identification of the abnormal testis facilitates surgical removal and precludes unnecessary excision of the contralateral normal testes. The authors recommended testicular sonography to be used as a routine procedure in all patients with such a clinical presentation...
April 1982: AJR. American Journal of Roentgenology
J U Brisbane, D A Howell, H L Bonkowsky
A case, unique in the literature, is reported in which a primary carcinoma of the liver presented a right-sided heart failure and pulmonary hypertension. The diagnosis of hepatocarcinoma was established by needle biopsy of the liver. Later, postmortem examination demonstrated that the pulmonary arterial tree was severely compromised by multiple tumor microemboli, despite the persistent lack of characteristic roentgenographic abnormality in our patient. In reviewing the literature, we found rare cases of occult renal cell carcinoma, choriocarcinoma and one of occult hepatocarcinoma, which presented as pulmonary embolism...
March 1980: American Journal of Medicine
J P Heiken, D M Balfe, B L McClennan
The extreme radiosensitivity of testicular seminomas plus recent advances in chemotherapy for nonseminomatous tumors and for advanced seminomas have made long term survival possible in the large majority of patients with testis cancer. Since choice of therapy is determined by tumor histology and extent of disease, accurate clinical staging is critical. Computed tomography (CT) of the abdomen and chest is the imaging procedure of choice for staging testis cancer. Clinical staging accuracy of 80 to 90% can be achieved using CT in combination with radioimmunoassays for beta-HCG and AFP...
February 1984: International Journal of Radiation Oncology, Biology, Physics
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