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cerebrovascular reserve

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https://www.readbyqxmd.com/read/29758591/mineralocorticoid-receptor-antagonism-prevents-obesity-induced-cerebral-artery-remodeling-and-reduces-white-matter-injury-in-rats
#1
Paulo Wagner Pires, Jonathon Lee McClain, Sebastian F Hayoz, Anne McLaren Dorrance
Midlife obesity is a risk factor for dementia development. Obesity has also been linked to hyperaldosteronism, and this can be modeled in rats by high fat (HF) feeding from weaning. Aldosterone, or activation of the mineralocorticoid receptor (MR) causes cerebrovascular injury in lean hypertensive rats. We hypothesized that rats fed a HF diet would show inward middle cerebral artery (MCA) remodeling that could be prevented by MR antagonism. We further proposed that the cerebral artery remodeling would be associated with white mater injury...
May 14, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29758114/time-well-spent-in-recanalizing-complex-cerebrovascular-occlusions
#2
Perttu J Lindsberg
After publication of several randomized, controlled trials demonstrating the efficacy of mechanical thrombectomy (MT) following intravenous t-PA (IV t-PA) the current guidelines of acute management of cerebrovascular have been revised (1,2). In addition to IV t-PA within 4,5 hours applied in a wide spectrum of ischemic stroke subtypes, MT has been proven as the second therapeutic target in a longer time window in much more selected cases of large vessel occlusions (LVO). This article is protected by copyright...
May 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29704393/correlation-between-herpes-zoster-and-stroke-a-case-control-study
#3
Hadiseh Hosamirudsari, Parisa Rashed, Farhad Afsari, Samaneh Akbarpour, Aliasghar Bagherzadeh
Cerebrovascular accident (CVA) is the second cause of death in the world. Herpes zoster (HZ) is reported as a major trigger of the stroke syndrome. Considering the high prevalence of stroke in Iran, we planned a study to assess the details of correlation between the stroke and herpes zoster (HZ).This is one of the very few studies carried out on the correlation in the Asian nations. One hundred five cases and 105 controls were included in this study. The cases had been diagnosed as stroke by a neurologist and confirmed by brain imaging...
April 28, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29672868/fetal-cerebral-circulation-as-target-of-maternal-alcohol-consumption
#4
Anna N Bukiya, Alex M Dopico
Alcohol (ethanol) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the US. The etiology of FAS/FASD remains poorly understood...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29616518/coronary-artery-bypass-surgery-in-patients-with-chronic-brain-hypoperfusion
#5
Hajime Imura, Yuji Maruyama, Kenichiro Takahashi, Dai Nishina, Takashi Nitta
BACKGROUND: Cerebrovascular disease (CVD) is a risk factor of stroke and cerebral hypoperfusion is one of the underlying mechanisms. We hypothesized that coronary artery bypass grafting (CABG) can be performed at an acceptable risk for such patients without concomitant surgery for CVD. METHODS: Carotid echo was carried out for 538 consecutive patients undergoing isolated CABG between 2005 and 2016. Magnetic resonance image/angiography (MRI/A) for neck and brain was performed for 288 patients (stenosis≥50% in echo were basically included)...
April 3, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29614647/reduced-cerebrovascular-reserve-capacity-as-a-biomarker-of-microangiopathy-in-alzheimer-s-disease-and-mild-cognitive-impairment
#6
Barbora Soukupova Urbanova, Jaroslava Paulasova Schwabova, Hana Magerova, Petr Jansky, Hana Markova, Martin Vyhnalek, Jan Laczo, Jakub Hort, Ales Tomek
BACKGROUND: Cerebral microangiopathy in Alzheimer's disease (AD) causes chronic hypoperfusion and probably accelerates neurodegenerative changes. OBJECTIVE: We hypothesize microvascular impairment could be present already in mild cognitive impairment (MCI) and can be revealed using transcranial color-coded sonography (TCCS) and the breath-holding maneuver. METHODS: Three groups of subjects (AD in the stage of dementia, MCI, and cognitively normal controls) with detailed neuropsychological testing and low cerebrovascular burden (no history of stroke, no intra- or extracranial artery stenoses, and no severe vascular lesions on brain MRI), underwent a TCCS assessment of peak systolic (PSV), mean flow (MFV), and end diastolic velocities (EDV) and resistance and pulsatility indices (RI, PI) in large intracranial vessels bilaterally...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29609199/incidence-and-prevalence-of-major-adverse-cardiovascular-events-in-rheumatoid-arthritis-psoriatic-arthritis-and-axial-spondyloarthritis
#7
Kim Lauper, Delphine S Courvoisier, Paola Chevallier, Axel Finckh, Cem Gabay
OBJECTIVE: The primary objective of this study was to compare the risk of major cardiovascular events (MACE) in a large observational cohort of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA) patients METHODS: We conducted a mixed retrospective and prospective cohort study using data from patients with RA, PsA and axSpA included in the Swiss Clinical Quality Management registry. The primary outcome of interest was a composite of myocardial infarction, transient or permanent cerebrovascular event, or CV associated death...
April 2, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29603492/demand-for-neurological-services-in-central-eastern-europe-a-10-year-national-survey-in-hungary
#8
Ferenc Oberfrank, András Ajtay, Dániel Bereczki
BACKGROUND: To plan neurological capacities at a national level for the next decade the current use of neurological services should be evaluated. We analyze the utilization of neurological services in Hungary, a country with a single-payer health insurance system covering the whole population. METHODS: We created a database from medical reports submitted to the National Health Insurance Fund from all hospitals and outpatient services between 2004 and 2013. The number of subjects presenting in the neurological healthcare system, and their major diagnoses by ICD-10 categories are analyzed...
March 30, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29574034/cerebrovascular-reactivity-cvr-mri-with-co2-challenge-a-technical-review
#9
Peiying Liu, Jill De Vis, Hanzhang Lu
Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides important information about vascular health in a range of brain conditions and diseases. Unlike steady-state vascular parameters, such as cerebral blood flow (CBF) and cerebral blood volume (CBV), CVR measures the ability of cerebral vessels to dilate or constrict in response to challenges or maneuvers. Therefore, CVR mapping requires a physiological challenge while monitoring the corresponding hemodynamic changes in the brain...
March 21, 2018: NeuroImage
https://www.readbyqxmd.com/read/29573497/inverse-association-for-diagnosis-of-alzheimer-s-disease-subsequent-to-both-melanoma-and-non-melanoma-skin-cancers-in-a-large-urban-single-center-midwestern-u-s-patient-population
#10
Erin Ibler, Gary Tran, Kelsey A Orrell, Linda Serrano, Sara Majewski, Kimberly A Sable, Rebecca Thiede, Anne E Laumann, Dennis P West, Beatrice Nardone
BACKGROUND: Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non-melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD. OBJECTIVE: The aim of this study is to determine if an association exists between MM and AD as well as for NMSC and AD. METHODS: A large urban, Midwestern, U...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29565505/changes-in-cerebrovascular-reactivity-in-healthy-adults-after-acute-exposure-to-high-altitude
#11
J Liu, S-K Zhang, J-M Luo, Q-Z Hu, W-Y Ma, S-Z Wu
OBJECTIVE:   To study changes in the cerebrovascular reactivity (CVR) at different altitude area in healthy adults. SUBJECTS AND METHODS: CVR was tested using transcranial Doppler combined with CO2 inhalation, near-infrared spectroscopy (NIRS) was used to detect the regional cerebral oxygen saturation (rScO2). Blood samples were collected, and the vasoactive substances in serum were detected using the enzyme-linked immunosorbent assay. In this study, 59 healthy adults were divided into 3 groups: low altitude group, medium altitude group and high altitude group...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29550248/revascularization-experience-and-results-in-ischaemic-cerebrovascular-disease-moyamoya-disease-and-carotid-occlusion
#12
Fuat Arikan, Marta Rubiera, Joaquín Serena, Ana Rodríguez-Hernández, Darío Gándara, Carles Lorenzo-Bosquet, Alejandro Tomasello, Ivette Chocrón, Maximiliano Quintana-Corvalan, Juan Sahuquillo
INTRODUCTION: Cerebral revascularization techniques are an indispensable tool in the current armamentarium of vascular neurosurgeons. We present revascularization surgery experience and results in both moyamoya disease and occlusive cerebral ischaemia. PATIENTS AND METHODS: Patients with ischaemic occlusive disease and moyamoya disease who underwent microsurgical revascularization between October 2014 and September 2017 were analysed. RESULTS: In the study period, 23 patients with occlusive ischaemic disease underwent microsurgical revascularization...
March 14, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29513397/anticoagulation-use-and-clinical-outcomes-after-catheter-ablation-in-patients-with-persistent-and-longstanding-persistent-atrial-fibrillation
#13
Jackson J Liang, Melissa A Elafros, Michael T Mullen, Daniele Muser, Tatsuya Hayashi, Andres Enriquez, Rajeev K Pathak, Erica S Zado, Pasquale Santangeli, Jeffrey S Arkles, Robert D Schaller, Gregory E Supple, David S Frankel, Fermin C Garcia, Rajat Deo, David Lin, Michael P Riley, Saman Nazarian, Sanjay Dixit, Francis E Marchlinski, David J Callans
INTRODUCTION: Whether successful catheter ablation for atrial fibrillation (AF) reduces risk of cerebrovascular events (CVEs) remains controversial and whether oral anticoagulation therapy (OAT) can be safely discontinued in patients rendered free of AF recurrences remains unknown. We evaluated OAT use patterns and examined long-term rates of CVEs (stroke/TIA) and major bleeding episodes (MBEs) in patients with nonparoxysmal AF treated with catheter ablation. METHODS AND RESULTS: Four hundred patients with nonparoxysmal AF (200 persistent, 200 longstanding persistent; mean age 60...
March 7, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29512224/physiology-of-static-breath-holding-in-elite-apneists
#14
REVIEW
Anthony R Bain, Ivan Drvis, Zeljko Dujic, David B MacLeod, Philip N Ainslie
NEW FINDINGS: What is the topic of this review? This review provides an up-to-date assessment of the physiology involved with extreme static dry-land breath holding in trained apneists. What advances does it highlight? We specifically highlight the recent findings involved with the cardiovascular, cerebrovascular and metabolic function during a maximal breath hold in elite apneists. ABSTRACT: Breath-hold-related activities have been performed for centuries, but only recently, within the last ∼30 years, has it emerged as an increasingly popular competitive sport...
May 1, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29509319/partial-loss-of-function-of-colony-stimulating-factor-1-receptor-in-a-patient-with-white-matter-abnormalities
#15
T Konno, T Miura, A M Harriott, N Mezaki, E S Edwards, R Rademakers, O A Ross, J F Meschia, T Ikeuchi, Z K Wszolek
BACKGROUND AND PURPOSE: Mutations in colony-stimulating factor 1 receptor (CSF1R) cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Patients with ALSP can be misdiagnosed as having acute ischemic stroke due to hyperintensity lesions on diffusion-weighted magnetic resonance imaging. Mutant CSF1R proteins identified in ALSP show a complete loss of autophosphorylation of CSF1R. METHODS: We conducted mutation screening of CSF1R in 123 patients with definite acute ischemic cerebrovascular syndrome and positive family history of stroke...
June 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29482876/low-carotid-stump-pressure-as-a-predictor-for-ischemic-symptoms-and-as-a-marker-for-compromised-cerebral-reserve-in-octogenarians-undergoing-carotid-endarterectomy
#16
Sam C Tyagi, Matthew J Dougherty, Shinichi Fukuhara, Douglas A Troutman, Danielle M Pineda, Hong Zheng, Keith D Calligaro
BACKGROUND: Carotid artery occlusive disease can cause stroke by embolization, thrombosis, and hypoperfusion. The majority of strokes secondary to cervical carotid atherosclerosis are believed to be of embolic etiology. However, cerebral hypoperfusion could be an important factor in perioperative stroke. We retrospectively reviewed the stump pressure (SP) of carotid endarterectomy (CEA) of patients at Pennsylvania Hospital to identify whether physiologic perfusion differences account for differences in perioperative stroke rates, particularly in octogenarians...
February 23, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29462837/reduced-arterial-vasodilatation-in-response-to-hypoxia-impairs-cerebral-and-peripheral-oxygen-delivery-in-hypertensive-men
#17
Igor A Fernandes, Marcos P Rocha, Monique O Campos, João D Mattos, Daniel E Mansur, Helena N M Rocha, Paulo A C Terra, Vinícius P Garcia, Natália G Rocha, Niels H Secher, Antonio C L Nóbrega
KEY POINTS: Hypoxaemia evokes a repertoire of homeostatic adjustments that maintain oxygen supply to organs and tissues including the brain and skeletal muscles. Because hypertensive patients have impaired endothelial-dependent vasodilatation and an increased sympathetic response to arterial oxygen desaturation, we investigated whether hypertension impairs isocapnic hypoxia-induced cerebral and skeletal muscle hyperaemia to an extent that limits oxygen supply. In middle-aged hypertensive men, vertebral and femoral artery blood flow do not increase in response to isocapnic hypoxia, limiting brain and peripheral hyperaemia and oxygen supply...
April 1, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29452984/quantitative-cerebrovascular-pathology-in-a-community-based-cohort-of-older-adults
#18
Swati Rane, Natalie Koh, Peter Boord, Tara Madhyastha, Mary K Askren, Suman Jayadev, Brenna Cholerton, Eric Larson, Thomas J Grabowski
Cerebrovascular disease, especially small vessel pathology, is the leading comorbidity in degenerative disorders. We applied arterial spin labeling and cerebrovascular reserve (CVR) imaging to quantify small vessel disease and study its effect on cognitive symptoms in nondemented older adults from a community-based cohort. We evaluated baseline cerebral blood flow (CBF) using arterial spin labeling and percent signal change as a marker of CVR using blood-oxygen level-dependent imaging following a breath-hold stimulus...
May 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29446829/injection-testosterone-and-adverse-cardiovascular-events-a-case-crossover-analysis
#19
J Bradley Layton, Dongmei Li, Christoph R Meier, Julie L Sharpless, Til Stürmer, M Alan Brookhart
CONTEXT: Exogenous testosterone administration may affect blood clotting, polycythaemia, and may increase atherosclerosis, though any association with cardiovascular events is unclear. While the literature is inconclusive, some studies have suggested testosterone use may increase short-term risk of cardiovascular events and stroke, and injection testosterone may convey higher risks than other dosage forms. OBJECTIVE: We sought to evaluate the short-term cardiovascular risk of receiving injection testosterone...
May 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29441169/perioperative-stroke-pathophysiology-and-management
#20
REVIEW
Sang-Bae Ko
Although perioperative stroke is uncommon during low-risk non-vascular surgery, if it occurs, it can negatively impact recovery from the surgery and functional outcome. Based on the Society for Neuroscience in Anesthesiology and Critical Care Consensus Statement, perioperative stroke includes intraoperative stroke, as well as postoperative stroke developing within 30 days after surgery. Factors related to perioperative stroke include age, sex, a history of stroke or transient ischemic attack, cardiac surgery (aortic surgery, mitral valve surgery, or coronary artery bypass graft surgery), and neurosurgery (external carotid-internal carotid bypass surgery, carotid endarterectomy, or aneurysm clipping)...
February 2018: Korean Journal of Anesthesiology
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