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cerebrovascular reserve

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https://www.readbyqxmd.com/read/29325217/neutrophil-infiltration-to-the-brain-is-platelet-dependent-and-is-reversed-by-blockade-of-platelet-gpib%C3%AE
#1
James A Giles, Andrew D Greenhalgh, Adam Denes, Bernhard Nieswandt, Graham Coutts, Barry W McColl, Stuart M Allan
Neutrophils are key components of the innate immune response, providing host defence against infection and being recruited to non-microbial injury sites. Platelets act as a trigger for neutrophil extravasation to inflammatory sites but mechanisms and tissue-specific aspects of these interactions are currently unclear. Here, we use bacterial endotoxin in mice to trigger an innate inflammatory response in different tissues and measure neutrophil invasion with or without platelet reduction. We show that platelets are essential for neutrophil infiltration to the brain, peritoneum and skin, neutrophil numbers returning to basal levels in the peritoneum and skin and being decreased (~60%) in the brain when platelets are reduced...
January 11, 2018: Immunology
https://www.readbyqxmd.com/read/29316357/cerebrovascular-events-in-systemic-lupus-erythematosus
#2
John G Hanly, Qiuju Li, Li Su, Murray B Urowitz, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Ann E Clarke, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, M A Dooley, Kristjan Steinsson, Rosalind Ramsey-Goldman, Asad A Zoma, Susan Manzi, Ola Nived, Andreas Jonsen, Munther A Khamashta, Graciela S Alarcón, Winn Chatham, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Manuel Ramos-Casals, S Sam Lim, Murat Inanc, Kenneth C Kalunian, Soren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askanase, Chris Theriault, Vernon Farewell
OBJECTIVE: To determine the frequency, associations and outcomes of cerebrovascular events (CerVEs) in a multi-ethnic/racial, prospective, SLE disease inception cohort. METHODS: Patients were assessed annually for 19 neuropsychiatric (NP) events including 5 types of CerVEs: (i) Stroke; (ii) Transient ischemia; (iii) Chronic multifocal ischemia; (iv) Subarachnoid/intracranial hemorrhage; (v) Sinus thrombosis. Global disease activity (SLEDAI-2K), SLICC/ACR damage index (SDI) and SF-36 scores were collected...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29314105/ambulatory-diagnostic-ecg-monitoring-for-syncope-and-collapse-an-assessment-of-clinical-practice-in-the-united-states
#3
David G Benditt, Wayne O Adkisson, Richard Sutton, Robin K Mears, Scott Sakaguchi
INTRODUCTION: Diagnostic ambulatory ECG (AECG) monitoring is widely used for evaluating syncope and collapse, and practice guidelines provide recommendations regarding optimal AECG device selection. However, whether physicians utilize AECGs in accordance with the pertinent guidelines is unclear. This study assessed utilization of AECG monitoring systems for syncope and collapse diagnosis by physicians in the United States. METHODS AND RESULTS: A quantitative survey was undertaken of physicians comprising multiple specialties (Emergency Room, n = 35; Primary care, n = 35; Hospitalists, n = 30; Neurologists, n = 30; non-implanting, n = 34 and implanting-Cardiologists, n = 35)...
January 4, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29281157/serum-neurofilament-light-chain-in-patients-with-acute-cerebrovascular-events
#4
Gian Marco De Marchis, Mira Katan, Christian Barro, Joachim Fladt, Christopher Traenka, David J Seiffge, Lisa Hert, Henrik Gensicke, Giulio Disanto, Raoul Sutter, Nils Peters, Hakan Sarikaya, Barbara Goeggel-Simonetti, Marwan El-Koussy, Stephan Engelter, Philippe A Lyrer, Mirjam Christ-Crain, Marcel Arnold, Jens Kuhle, Leo H Bonati
BACKGROUND AND PURPOSE: Serum Neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) and TIA. METHODS: Nested within a prospective cohort study, we compared serum neurofilament light chain levels (sNfL) drawn within 24 hours from symptom onset in patients with AIS or TIA. Patients without MRI on admission were excluded. We assessed if sNfL are associated with: (i) clinical severity on admission, (ii) diagnosis of AIS vs TIA, (iii) infarct size on admission diffusion weighted imaging (MR-DWI), and (iv) functional outcome at 3 months...
December 27, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29274451/treatment-of-progressive-herpes-zoster-induced-vasculopathy-with-surgical-revascularization-effects-on-cerebral-hemodynamics
#5
Sarah K Lants, Jennifer M Watchmaker, Meher R Juttukonda, Larry T Davis, Manus J Donahue, Matthew R Fusco
BACKGROUND: Herpes zoster ophthalmicus (HZO) is caused by the reactivation of the herpes simplex virus in the trigeminal nerve. HZO-initiated cerebral vasculopathy is well-characterized, however there are no documented cases that report the efficacy of surgical revascularization for improving cerebral hemodynamics following progressive HZO-induced vasculopathy. We present a case where quantitative anatomical and hemodynamic imaging were performed longitudinally before and after surgical revascularization in a patient with HZO and vasculopathic changes...
December 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29230812/the-gut-microbiota-an-emerging-risk-factor-for-cardiovascular-and-cerebrovascular-disease
#6
REVIEW
Stefanie Ascher, Christoph Reinhardt
Commensal gut microbiota have recently been implicated in cardiovascular disease (CVD) and cerebrovascular disease. Atherosclerotic plaque formation depends on the colonization status of the host. In addition to host nutrition and the related microbiota-dependent metabolic changes, activation of innate immune pathways triggers the development of atherosclerosis and supports arterial thrombosis. Gnotobiotic mouse models have uncovered that activation of Toll-like receptor-2 by gut microbial ligands supports von Willebrand factor-integrin mediated platelet deposition to the site of vascular injury...
December 12, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29222955/brain-comorbidities-in-normal-pressure-hydrocephalus
#7
Gilles Allali, Magali Laidet, Stéphane Armand, Frédéric Assal
BACKGROUND: This cross-sectional study aims to compare gait changes after CSF tap test between normal pressure hydrocephalus patients with and without brain comorbidities (respectively NPH+ and NPH); and then identify significant contributors to poor CSF tap test among individuals with NPH+. METHODS: Gait changes (during single and dual task of backward counting) were quantified before and 24 hours after CSF tap test with an optoelectronic system in 52 NPH patients (77...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29222909/an-emerging-role-of-astrocytes-in-vascular-contributions-to-cognitive-impairment-and-dementia-vcid
#8
REVIEW
Brittani R Price, Christopher M Norris, Pradoldej Sompol, Donna M Wilcock
Vascular contributions to cognitive impairment and dementia (VCID) is understood to be the second most common cause of dementia after Alzheimer's disease (AD), and is also a frequent co-morbidity with AD. While VCID is widely acknowledged as a key contributor to dementia, the mechanistic underpinnings of VCID remain poorly understood. In this review, we address the potential role of astrocytes in the pathophysiology of VCID. The vast majority of the blood vessels in the brain are surrounded by astrocytic end-feet...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29220869/non-obese-fatty-liver-disease-is-associated-with-lacunar-infarct
#9
Min-Sun Kwak, Kyung Won Kim, Hyobin Seo, Goh-Eun Chung, Jeong Yoon Yim, Donghee Kim
BACKGROUND/AIMS: Lacunar infarct, a small subcortical ischemic lesion, is a known risk factor for future cognitive impairment, dementia, and stroke. We evaluated the relationship between fatty liver disease(FLD) and lacunar infarct in a healthy general population. METHODS: Subjects who underwent brain magnetic resonance imaging(MRI) and abdominal ultrasonography(US) during health check-ups from 2007-2009 were included. FLD was diagnosed by US. Subjects with a history of cerebrovascular disease, radiological findings consistent with cerebrovascular stenosis, or cerebral small vessel disease were excluded...
December 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29211948/simultaneous-determination-of-polysaccharides-and-21-nucleosides-and-amino-acids-in-different-tissues-of-salvia-miltiorrhiza-from-different-areas-by-uv-visible-spectrophotometry-and-uhplc-with-triple-quadrupole-ms-ms
#10
Xiang Xiang, Xiuxiu Sha, Shulan Su, Zhenhua Zhu, Sheng Guo, Hui Yan, Dawei Qian, Jin-Ao Duan
Salvia miltiorrhiza, a traditional Chinese medicine, is a widely used herbal medicine to treat cardiovascular and cerebrovascular diseases. In this study, ultraviolet-visible spectrophotometry and ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry analytical methods for rapidly quantifying polysaccharides, 21 nucleosides and amino acids in S.miltiorrhiza were established to determine 17 samples of different tissues from different areas. Based on the total contents, hierarchical clustering analysis and principal components analysis were performed to classify these samples...
December 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29180090/neurological-deterioration-in-patients-with-moyamoya-disease-during-pregnancy-delivery-and-puerperium
#11
Wonhyoung Park, Jae Sung Ahn, Jaewoo Chung, Yeongu Chung, Seungjoo Lee, Jung Cheol Park, Byung Duk Kwun
BACKGROUND: We reviewed our clinical experience of patients with moyamoya disease (MMD) who gave birth and assessed characteristics of those experiencing neurological deterioration. METHODS: The patients were classified into patients diagnosed with MMD during pregnancy and puerperium (Group 1) and those diagnosed before pregnancy (Group 2). We retrospectively reviewed patient characteristics, MMD treatment, neurological symptoms before and during pregnancy and/after puerperium, obstetrical history, and delivery type in Groups 1 and 2...
November 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29161767/effects-of-different-endurance-exercise-modalities-on-migraine-days-and-cerebrovascular-health-in-episodic-migraineurs-a-randomized-controlled-trial
#12
Henner Hanssen, Alice Minghetti, Stefano Magon, Anja Rossmeissl, Maria Rasenack, Athina Papadopoulou, Christopher Klenk, Oliver Faude, Lukas Zahner, Till Sprenger, Lars Donath
BACKGROUND: Aerobic exercise training is a promising complementary treatment option in migraine and can reduce migraine days and improve retinal microvascular function. Our aim was to elucidate whether different aerobic exercise programs at high vs. moderate intensities distinctly affect migraine days as primary outcome and retinal vessel parameters as a secondary. METHODS: In this randomized controlled trial, migraine days were recorded by a validated migraine diary in 45 migraineurs of which 36 (female: 28; age: 36 (SD:10)/ BMI: 23...
November 21, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29146719/can-arterial-spin-labeling-with-multiple-postlabeling-delays-predict-cerebrovascular-reserve
#13
H J Choi, C-H Sohn, S-H You, R-E Yoo, K M Kang, T J Yun, S H Choi, J-H Kim, W-S Cho, J E Kim
BACKGROUND AND PURPOSE: The effect of delayed transit time is the main source of error in the quantitative measurement of CBF in arterial spin-labeling. In the present study, we evaluated the usefulness of the transit time-corrected CBF and arterial transit time delay from multiple postlabeling delays arterial spin-labeling compared with basal/acetazolamide stress technetium Tc99m-hexamethylpropylene amineoxime (Tc99m-HMPAO) SPECT in predicting impairment in the cerebrovascular reserve...
January 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29103148/cerebrovascular-co2-reactivity-during-isoflurane-nitrous-oxide-anesthesia-in-patients-with-chronic-renal-failure
#14
Kazuyoshi Ishida, Masato Uchida, Kohji Utada, Atsuo Yamashita, Satoshi Yamashita, Shiro Fukuda, Mishiya Matsumoto, Takefumi Sakabe
PURPOSE: We assessed the cerebrovascular CO2 reactivity (CO2R) in chronic renal failure (CRF) patients without diabetes mellitus (DM), uncontrolled hypertension, peripheral vascular disease, or neurological disease under isoflurane-nitrous oxide anesthesia. METHODS: Forty-nine patients undergoing surgery, including 36 CRF patients (30 receiving dialysis and six pre-dialysis patients) and 13 patients without CRF (controls). Middle cerebral artery flow velocity (VMCA) was measured by transcranial Doppler ultrasonography at an end-tidal CO2 of 35 to 45 mmHg...
November 4, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29102362/drug-eluting-stents-in-elderly-patients-with-coronary-artery-disease-senior-a-randomised-single-blind-trial
#15
Olivier Varenne, Stéphane Cook, Georgios Sideris, Sasko Kedev, Thomas Cuisset, Didier Carrié, Thomas Hovasse, Philippe Garot, Rami El Mahmoud, Christian Spaulding, Gérard Helft, José F Diaz Fernandez, Salvatore Brugaletta, Eduardo Pinar-Bermudez, Josepa Mauri Ferre, Philippe Commeau, Emmanuel Teiger, Kris Bogaerts, Manel Sabate, Marie-Claude Morice, Peter R Sinnaeve
BACKGROUND: Elderly patients regularly receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of double antiplatelet therapy (DAPT). The aim of this study was to compare outcomes between these two types of stents with a short duration of DAPT in such patients. METHODS: In this randomised single-blind trial, we recruited patients from 44 centres in nine countries. Patients were eligible if they were aged 75 years or older; had stable angina, silent ischaemia, or an acute coronary syndrome; and had at least one coronary artery with a stenosis of at least 70% (≥50% for the left main stem) deemed eligible for percutaneous coronary intervention (PCI)...
October 31, 2017: Lancet
https://www.readbyqxmd.com/read/29066902/effects-of-sevoflurane-versus-propofol-on-cerebrovascular-reactivity-to-carbon-dioxide-during-laparoscopic-surgery
#16
Chunyi Wang, Cheng Ni, Gang Li, Yan Li, Liyuan Tao, Nan Li, Jun Wang, Xiangyang Guo
PURPOSE: Cerebrovascular reactivity to carbon dioxide (CVR-CO2) reflects cerebrovascular reserve capacity, which is important in many brain disorders, including cerebrovascular and Alzheimer's diseases. Meanwhile, there is a relationship between CVR-CO2 and cognitive function. Therefore, the study is aimed at investigating the effects of sevoflurane versus propofol on CVR-CO2 during laparoscopic surgery, as well as the role of CVR-CO2 on cognitive function during perioperative period...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29064737/effects-of-apoe-haplotypes-and-measures-of-cardiovascular-risk-over-gender-dependent-cognitive-and-functional-changes-in-one-year-in-alzheimer-s-disease
#17
Fabricio Ferreira de Oliveira, Fernando Vieira Pereira, Glaucia Akiko Kamikado Pivi, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
BACKGROUND: Illiteracy, high cerebrovascular risk and copies of APOE-ϵ4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decline of AD in one year. METHODS: Consecutive outpatients with late-onset AD were assessed for gender, schooling, BMI and APOE haplotypes, variations in one year of creatinine clearance and Framingham projections of the 10-year absolute CHD risk, and prospective scores of the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating Sum-of-Boxes (CDR-SOB), the Index of Independence in Activities of Daily Living (ADL) and Lawton's Scale for Instrumental Activities of Daily Living (IADL)...
October 24, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29055168/long-term-safety-of-growth-hormone-a-combined-registry-analysis
#18
Kirstine Stochholm, Wieland Kiess
OBJECTIVES: Preliminary data from the French cohort of the Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) study raised concerns regarding the safety of recombinant human GH, suggesting that GH may increase mortality and incidence of stroke in patients treated during childhood for GH deficiency or short stature. We evaluated published safety data, focusing on mortality, neoplasms, cerebrovascular events and diabetes across a number of large-scale pharmaceutical company GH registries...
October 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29055086/acute-mitogen-activated-protein-kinase-1-2-inhibition-improves-functional-recovery-and-vascular-changes-after-ischemic-stroke-in-rat-monitored-by-9-4-t-magnetic-resonance-imaging
#19
Maryam Mostajeran, Friedrich Wetterling, Frank W Blixt, Lars Edvinsson, Saema Ansar
AIM: The aim was to evaluate the beneficial effect of early mitogen activated protein kinase (MEK)1/2 inhibition administered at a clinical relevant time-point using the transient middle cerebral artery occlusion model and a dedicated rodent magnetic resonance imaging system (9.4T) to monitor cerebrovascular changes non-invasively for two weeks. METHOD: Transient middle cerebral artery occlusion was induced in male rats for two hours followed by reperfusion. The specific MEK1/2 inhibitor U0126 was administered i...
October 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29053903/galectin-3-an-emerging-biomarker-in-stroke-and-cerebrovascular-diseases
#20
Anand Venkatraman, Shalaka Hardas, Nirav Patel, Navkaranbir Singh Bajaj, Garima Arora, Pankaj Arora
BACKGROUND: The carbohydrate-binding molecule Galectin-3 has garnered significant attention recently as a biomarker for various conditions ranging from cardiac disease to obesity. Though there have been several recent studies investigating its role in stroke and other cerebrovascular diseases, awareness of this emerging biomarker in the wider neurology community is limited. METHODS: We performed a systematic search in PubMed, EMBASE, Scopus, CINAHL, Clinicaltrials...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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