keyword
MENU ▼
Read by QxMD icon Read
search

IgG4 guidelines

keyword
https://www.readbyqxmd.com/read/28701054/diagnostic-and-treatment-workup-for-igg4-related-disease
#1
Mary Abraham, Arezou Khosroshahi
IgG4-Related Disease is a newly recognized condition which is increasingly diagnosed by practitioners due to improvement in clinical awareness. Men and women have been found to be affected by this disease in various organs, more commonly with involvement of the salivary and lacrimal glands as well as pancreas and liver. Areas covered: The diagnosis and management of this condition remain challenging as biomarkers and therapies are being investigated. Hallmark features on histology are still the gold standard for confirmation of diagnosis, whereas serum IgG4 level has been shown to be neither necessary nor sufficient for the diagnosis...
September 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28681251/igg4-related-disease-a-complex-under-diagnosed-clinical-entity
#2
REVIEW
Sujani Yadlapati, Elijah Verheyen, Petros Efthimiou
IgG4-related disease (IgG4-RD) encompasses a spectrum of complex fibro-inflammatory disorders which are often under diagnosed due to unfamiliarity by clinicians. A challenging multitude of clinical manifestations makes the diagnosis cumbersome. The primary clinical feature in IgG4-RD entails a tumor-like presentation coupled with tissue-destructive lesions. Histopathological findings include lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis. These findings, in combination with elevated serum immunoglobulin G4 levels, are diagnostic in the setting of single- or multi-organ involvement...
July 5, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28570731/consensus-on-diagnostic-criteria-of-idiopathic-orbital-inflammation-using-a-modified-delphi-approach
#3
Ilse Mombaerts, Jurij R Bilyk, Geoffrey E Rose, Alan A McNab, Aaron Fay, Peter J Dolman, Richard C Allen, Martin H Devoto, Gerald J Harris
Importance: Current practice to diagnose idiopathic orbital inflammation (IOI) is inconsistent, leading to frequent misdiagnosis of other orbital entities, including cancer. By specifying criteria, diagnosis of orbital inflammation will be improved. Objective: To define a set of criteria specific for the diagnosis of IOI. Design, Setting, and Participants: A 3-round modified Delphi process with an expert panel was conducted from June 8, 2015, to January 25, 2016...
July 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28114304/modelling-anti-ov16-igg4-antibody-prevalence-as-an-indicator-for-evaluation-and-decision-making-in-onchocerciasis-elimination-programmes
#4
Yvonne L Lont, Luc E Coffeng, Sake J de Vlas, Allison Golden, Tala de Los Santos, Gonzalo J Domingo, Wilma A Stolk
BACKGROUND: Onchocerciasis is targeted for elimination in Africa through annual or biannual ivermectin mass drug administration (MDA). An immunodiagnostic test, based on the detection of human IgG4 antibodies in the blood to the Onchocerca volvulus-specific antigen Ov16, is one of the recommended tools for determining whether transmission is interrupted and mass treatment can stop. For different transmission settings, the relationship between post-MDA Ov16 antibody prevalence in children (measured 1 year after the last round of MDA) and the duration and coverage of MDA, the mf prevalence in the population, and the probability that onchocerciasis is eventually eliminated is explored through mathematical modelling...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28090683/similar-but-not-consistent-revisiting-the-pitfalls-of-measuring-igg-subclasses-with-different-assays
#5
Beatrice Ludwig-Kraus, Frank Bernhard Kraus
BACKGROUND: Laboratory quantification of IgG subclasses (IgGSc) is a well-established second-line tool for differential diagnosis of immune deficiencies. However, so far there is still no internationally approved standard available for IgGSc, and different assays are prone to produce divergent results. In this study, we evaluated the comparability and equivalence of two commercially available IgGSc assays, one being the Siemens IgGSc assay on a BN ProSpec analyzer and the other being The Binding Site (TBS) IgGSc assay on a Roche cobas c502 analyzer...
January 16, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28034767/interruption-of-the-transmission-of-onchocerca-volvulus-in-the-kashoya-kitomi-focus-western-uganda-by-long-term-ivermectin-treatment-and-elimination-of-the-vector-simulium-neavei-by-larviciding
#6
T Lakwo, R Garms, J Wamani, E M Tukahebwa, E Byamukama, A W Onapa, E Tukesiga, J Katamanywa, S Begumisa, P Habomugisha, D Oguttu, E Byamukama, F Richards, T R Unnasch, M Katabarwa
Uganda is the only country in sub-Saharan Africa whose onchocerciasis elimination programme extensively uses vector control and biannual treatment with ivermectin. The purpose of this study was to assess the impact of combined strategies on interrupting onchocerciasis transmission in the Kashoya-Kitomi focus. Mass Drug Administration annually (13 years) followed by biannual treatments (6 years) and ground larviciding (36 cycles in 3 years) with temephos (Abate(®), EC500) against Simulium neavei were conducted...
March 2017: Acta Tropica
https://www.readbyqxmd.com/read/27914210/randomized-controlled-trial-of-oral-immunotherapy-for-egg-allergy-in-japanese-patients
#7
Masayuki Akashi, Hiroki Yasudo, Masami Narita, Ichiro Nomura, Akira Akasawa, Motohiro Ebisawa, Takao Takahashi, Yukihiro Ohya
BACKGROUND: Egg allergy is one of the most common food allergies in young children. While oral immunotherapy (OIT) is not routinely recommended in current guidelines, it has been considered as a potential alternative treatment strategy. Studies on OIT for food allergy have been explored, but no controlled trials have been reported in Japan. METHODS: The first oral food challenge (OFC) was performed before treatment to ensure diagnosis and evaluate the threshold dose for egg using the double-blind, placebo-controlled food challenge...
May 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27638824/-igg4-associated-diseases-state-of-the-art
#8
A Kleger, T Seufferlein
CLINICAL ISSUE: IgG4-related diseases are rare but the incidence is continuously increasing. The pathophysiology is only incompletely understood. Multiorgan involvement correlates with high relapse rates, high serum IgG4 levels and an aggressive disease course, which is why diagnostics and therapy must be carried out rapidly and efficiently according to international guidelines despite all the difficulties. STANDARD TREATMENT: Currently the therapeutic standard is initial therapy (induction therapy) with glucocorticosteroids over a longer period of time and if necessary followed by low-dose maintenance therapy...
December 2016: Der Radiologe
https://www.readbyqxmd.com/read/27517527/immunoglobulin-g4-related-disease-mimicking-an-epidural-spinal-cord-tumor-case-report
#9
Michelle M Williams, Hazem Mashaly, Vinay K Puduvalli, Ming Jin, Ehud Mendel
The authors report a case of immunoglobulin G4-related disease (IgG4-RD) presenting as a paraspinal, epidural mass. This disease encompasses a host of autoimmune conditions that were previously thought to be separate entities. It is characterized by fibrosis, mediated by the aberrant proliferation and tissue invasion of IgG4-positive plasma cells, which can occur in any organ. As with other autoimmune conditions, it tends to be responsive to steroids and other immunosuppressants. It can rarely present as a tumefactive lesion of the central nervous system, creating the potential for misdiagnosis (given its similar radiological appearance to malignancy) and mistreatment...
January 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27479043/automated-high-throughput-permethylation-for-glycosylation-analysis-of-biologics-using-maldi-tof-ms
#10
Archana Shubhakar, Radoslaw P Kozak, Karli R Reiding, Louise Royle, Daniel I R Spencer, Daryl L Fernandes, Manfred Wuhrer
Monitoring glycoprotein therapeutics for changes in glycosylation throughout the drug's life cycle is vital, as glycans significantly modulate the stability, biological activity, serum half-life, safety, and immunogenicity. Biopharma companies are increasingly adopting Quality by Design (QbD) frameworks for measuring, optimizing, and controlling drug glycosylation. Permethylation of glycans prior to analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is a valuable tool for glycan characterization and for screening of large numbers of samples in QbD drug realization...
September 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27391401/an-orphan-disease-igg4-related-spinal-pachymeningitis-report-of-2-cases
#11
Bishan D Radotra, Ashish Aggarwal, Ankur Kapoor, Navneet Singla, Debajyoti Chatterjee
IgG4-related disease is relatively new disease entity and a rare one, and our knowledge of this entity continues to evolve. It was first described in the pancreas and since then has been described in virtually every organ. Spinal involvement resulting in pachymeningitis is rare, and there are only 8 reported cases of the same to date, with the cervicothoracic spine being the most commonly affected region. The authors describe 2 cases in which the patients presented with spinal compression resulting in myeloradiculopathy (Case 1) and radiculopathy (Case 2)...
December 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27111568/longitudinal-profiles-of-serum-specific-ige-and-igg4-to-dermatophagoides-pteronyssinus-allergen-and-its-major-components-during-allergen-immunotherapy-in-a-cohort-of-southern-chinese-children
#12
Guangqiao Zeng, Peiyan Zheng, Wenting Luo, Huimin Huang, Nili Wei, Baoqing Sun
Longitudinal data on serum specific sIgE and sIgG4 to allergen component of Dermatophagoides pteronyssinus (Der p) during allergen immunotherapy (AIT) are limited in Chinese populations. We serially followed up serum sIgE and sIgG4 to Der p and its components (Der p 1 and 2) in 51 Der p-sensitized children receiving guideline-based medications alone and additional 36-month AIT. The the Der p 1 and Der p 2 sIgE levels were elevated at 6 months and progressively declined from 12 months; the sIgG4 levels for Der p, Der p 1 and Der p 2 were increasing during the first year and reached a plateau thereafter; the sIgE/sIgG4 ratios for Der p 1 and Der p 2 decreased continuously from 6 through 24 months of AIT...
June 2016: Molecular Immunology
https://www.readbyqxmd.com/read/26975445/prevalence-and-pattern-of-humoral-immunodeficiency-in-chronic-refractory-sinusitis
#13
Haitham Odat, Mohannad Alqudah
The purpose of this study is to readdress the issue of primary humoral immunodeficiency frequency and pattern in medically resistant chronic rhinosinusitis (CRS) based on the new guidelines for CRS diagnosis and management. Two hundred and fifty-seven consecutive patients with refractory CRS were included in this study. The results of their IgA, IgM, IgG, and IgG subclasses were analyzed and compared with 75 age- and gender-matched control groups. The average age of CRS patients was 34 years (SD ± 13). In the refractory CRS group, there was no significant difference between patients with or without humoral immunodeficiency based on age, gender and status of allergy, polyps and revision...
October 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/26886206/clinical-features-pathogenesis-and-treatment-of-myasthenia-gravis-a-supplement-to-the-guidelines-of-the-german-neurological-society
#14
REVIEW
Nico Melzer, Tobias Ruck, Peter Fuhr, Ralf Gold, Reinhard Hohlfeld, Alexander Marx, Arthur Melms, Björn Tackenberg, Berthold Schalke, Christiane Schneider-Gold, Fritz Zimprich, Sven G Meuth, Heinz Wiendl
Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and weakness affecting ocular, bulbar and (proximal) limb skeletal muscle groups. MG may either occur as an autoimmune disease with distinct immunogenetic characteristics or as a paraneoplastic syndrome associated with tumors of the thymus. Impairment of central thymic and peripheral self-tolerance mechanisms in both cases is thought to favor an autoimmune CD4(+) T cell-mediated B cell activation and synthesis of pathogenic high-affinity autoantibodies of either the IgG1 and 3 or IgG4 subclass...
August 2016: Journal of Neurology
https://www.readbyqxmd.com/read/26640943/diagnosis-differential-diagnosis-and-epidemiology-of-primary-sclerosing-cholangitis
#15
REVIEW
Cyriel Y Ponsioen
According to recent guidelines, primary sclerosing cholangitis (PSC) is diagnosed when a patient has a cholestatic liver enzyme profile, characteristic bile duct changes on imaging, and when secondary causes of sclerosing cholangitis are excluded. In patients with a clinical suspicion but normal cholangiography, a liver biopsy is indicated to establish a diagnosis of small duct PSC. Several other disease entities such as IgG4-associated cholangitis (IAC), cholangiocarcinoma (CCA), and secondary causes of sclerosing cholangitis such as choledocholithiasis, AIDS-cholangiopathy, ischemia, surgical bile duct trauma, or mast cell cholangiopathy can mimic PSC...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/26503275/one-hundred-years-after-its-discovery-in-guatemala-by-rodolfo-robles-onchocerca-volvulus-transmission-has-been-eliminated-from-the-central-endemic-zone
#16
Frank Richards, Nidia Rizzo, Carlos Enrique Diaz Espinoza, Zoraida Morales Monroy, Carol Guillermina Crovella Valdez, Renata Mendizabal de Cabrera, Oscar de Leon, Guillermo Zea-Flores, Mauricio Sauerbrey, Alba Lucia Morales, Dalila Rios, Thomas R Unnasch, Hassan K Hassan, Robert Klein, Mark Eberhard, Ed Cupp, Alfredo Domínguez
We report the elimination of Onchocerca volvulus transmission from the Central Endemic Zone (CEZ) of onchocerciasis in Guatemala, the largest focus of this disease in the Americas and the first to be discovered in this hemisphere by Rodolfo Robles Valverde in 1915. Mass drug administration (MDA) with ivermectin was launched in 1988, with semiannual MDA coverage reaching at least 85% of the eligible population in > 95% of treatment rounds during the 12-year period, 2000-2011. Serial parasitological testing to monitor MDA impact in sentinel villages showed a decrease in microfilaria skin prevalence from 70% to 0%, and polymerase chain reaction (PCR)-based entomological assessments of the principal vector Simulium ochraceum s...
December 2015: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/25917543/fdg-pet-ct-in-infection-and-inflammation-current-and-emerging-clinical-applications
#17
REVIEW
S Vaidyanathan, C N Patel, A F Scarsbrook, F U Chowdhury
Integrated positron emission tomography/computed tomography (PET/CT) with the glucose analogue, 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG), is an evolving hybrid imaging technique in the evaluation of an important and diverse group of pathological conditions, which are characterised by infection and aseptic inflammation. With a rapidly expanding body of evidence, it is being increasingly recognised that, in addition to its established role in oncological imaging, FDG PET/CT also has clinical utility in suspected infection and inflammation...
July 2015: Clinical Radiology
https://www.readbyqxmd.com/read/24920744/-a-case-of-possible-immunoglobulin-g4-related-disease-igg4-rd-with-retroperitoneal-fibrosis-and-central-diabetes-insipidus-due-to-infundibulohypophysitis
#18
Jun Tanaka, Atsushi Arai, Shigeto Hayashi, Yoshio Sakagami, Kota Araki, Seiji Kakiuchi, Tetsuhiko Nomura, Keiichi Kuwamura, Eiji Kohmura
We report a case of possible immunoglobulin G4-related disease(IgG4-RD)that resulted in complications such as retroperitoneal fibrosis and infundibulohypophysitis. The patient was a 72-year-old male who presented with polyuria and polydipsia. Magnetic resonance imaging(MRI)revealed a thickened pituitary stalk and contrast enhancement with gadolinium. T1-weighted imaging revealed that the posterior pituitary high-signal zone had disappeared. Central diabetes insipidus was diagnosed on the basis of results of the hypertonic saline test...
June 2014: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/24639058/amendment-of-the-japanese-consensus-guidelines-for-autoimmune-pancreatitis-2013-iii-treatment-and-prognosis-of-autoimmune-pancreatitis
#19
Terumi Kamisawa, Kazuichi Okazaki, Shigeyuki Kawa, Tetsuhide Ito, Kazuo Inui, Hiroyuki Irie, Takayoshi Nishino, Kenji Notohara, Isao Nishimori, Shigeki Tanaka, Toshimasa Nishiyama, Koichi Suda, Keiko Shiratori, Masao Tanaka, Tooru Shimosegawa
The standard treatment for autoimmune pancreatitis (AIP) is steroid therapy, although some patients improve spontaneously. Indications for steroid therapy in AIP patients are symptoms such as obstructive jaundice, abdominal pain, back pain, and the presence of symptomatic extrapancreatic lesions. Prior to steroid therapy, obstructive jaundice should be managed by biliary drainage, and blood glucose levels should be controlled in patients with diabetes mellitus. The recommended initial oral prednisolone dose for induction of remission is 0...
June 2014: Journal of Gastroenterology
https://www.readbyqxmd.com/read/24424184/diagnosis-and-classification-of-autoimmune-pancreatitis
#20
REVIEW
Kazuichi Okazaki, Takashi Tomiyama, Toshiyuki Mitsuyama, Kimi Sumimoto, Kazushige Uchida
Recent studies suggested the existence of two subtypes of autoimmune pancreatitis (AIP): type 1 related with IgG4 as the pancreatic manifestation of IgG4-related disease (IgG4-RD), and type 2 related with a granulocytic epithelial lesion. Apart from type 2 AIP, the characteristic features of type 1 AIP are increased serum IgG4 levels, lymphoplasmacytic sclerosing pancreatitis (abundant infiltration of IgG4+ plasmacytes and lymphocytes, storiform fibrosis, and obliterative phlebitis), extra-pancreatic manifestations of IgG4-RD (e...
April 2014: Autoimmunity Reviews
keyword
keyword
72816
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"