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https://www.readbyqxmd.com/read/28329999/bilateral-cystic-coloboma-with-microphtalmos-and-eyelid-agenesis-us-and-mri-findings
#1
Youssef Omor, Benjamin Dhaene, Veronique Toppet, Marie Cassart, Patrice Jissendi-Tchofo
INTRODUCTION: The combination of bilateral microphthalmos, cystic coloboma and eyelid agenesis is rare. The definite diagnosis of this malformation is established by fundoscopic examination and confirmed by imaging modalities such as ultrasonography (US) and magnetic resonance imaging (MRI). This disorder may be associated with specific chromosomal abnormalities. CASE REPORT: A 1-week-old male newborn was referred for bilateral eyelid agenesis. He was born at term by caesarean for foetal distress, after an uneventful gestation...
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28328799/oral-microbiome-in-hiv-associated-periodontitis
#2
Marc Noguera-Julian, Yolanda Guillén, Jessica Peterson, David Reznik, Erica V Harris, Sandeep J Joseph, Javier Rivera, Sunil Kannanganat, Rama Amara, Minh Ly Nguyen, Simon Mutembo, Roger Paredes, Timothy D Read, Vincent C Marconi
HIV-associated periodontal diseases (PD) could serve as a source of chronic inflammation. Here, we sought to characterize the oral microbial signatures of HIV+ and HIV- individuals at different levels of PD severity.This cross-sectional study included both HIV+ and HIV- patients with varying degrees of PD. Two tooth, 2 cheek, and 1 saliva samples were obtained for microbiome analysis. Mothur/SILVADB were used to classify sequences. R/Bioconductor (Vegan, PhyloSeq, and DESeq2) was employed to assess overall microbiome structure differences and differential abundance of bacterial genera between groups...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328207/same-precursor-two-different-products-comparing-the-structural-evolution-of-in-ga-o-gel-derived-powders-and-so-lution-cast-films-using-pair-distribution-function-analysis
#3
Suzannah R Wood, Keenan N Woods, Paul N Plassmeyer, David A Marsh, Darren W Johnson, Catherine J Page, Kirsten M O Jensen, David C Johnson
Amorphous metal oxides are central to a variety of technological applications. In particular, indium gallium oxide has garnered attention as a thin-film transistor channel layer material. In this work we examine the structural evolution of indium gallium oxide gel-derived powders and thin films using X-ray diffraction, infrared vibrational spectroscopy, and pair distribution function analysis of X-ray total scattering from standard (PDF) and normal incidence thin film (tfPDF) geometries. We find that the gel-derived powders and films from the same aqueous precursor evolve differently with temperature, forming mixtures of Ga-substituted In2O3 and In-substituted β-Ga2O3 with different degrees of substitution...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28326298/effects-of-escherichia-coli-derived-recombinant-human-bone-morphogenetic-protein-2-loaded-porous-hydroxyaptite-based-ceramics-on-calvarial-defect-in-rabbits
#4
Shin-Young Kim, Youngkyun Lee, Seung-Jun Seo, Jae-Hong Lim, Yong-Gun Kim
BACKGROUND: Recombinant human bone morphogenetic proteins (rhBMPs) have been widely used in regenerative therapies to promote bone formation. The production of rhBMPs using bacterial systems such as Escherichia coli (E. coli) is estimated to facilitate clinical applications by lowering the cost without compromising biological activity. In clinical practice, rhBMP-2 and osteoconductive carriers (e.g., hydroxyapatite [HA] and bovine bone xenograft) are used together. This study examined the effect of E...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28325895/simulation-assisted-design-of-microfluidic-sample-traps-for-optimal-trapping-and-culture-of-non-adherent-single-cells-tissues-and-spheroids
#5
Nassim Rousset, Frédéric Monet, Thomas Gervais
This work focuses on modelling design and operation of "microfluidic sample traps" (MSTs). MSTs regroup a widely used class of microdevices that incorporate wells, recesses or chambers adjacent to a channel to individually trap, culture and/or release submicroliter 3D tissue samples ranging from simple cell aggregates and spheroids, to ex vivo tissue samples and other submillimetre-scale tissue models. Numerous MST designs employing various trapping mechanisms have been proposed in the literature, spurring the development of 3D tissue models for drug discovery and personalized medicine...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325831/landscape-genomic-insights-into-the-historic-migration-of-mountain-hemlock-in-response-to-holocene-climate-change
#6
Jeremy S Johnson, Keith D Gaddis, David M Cairns, Kranti Konganti, Konstantin V Krutovsky
PREMISE OF THE STUDY: Untangling alternative historic dispersal pathways in long-lived tree species is critical to better understand how temperate tree species may respond to climatic change. However, disentangling these alternative pathways is often difficult. Emerging genomic technologies and landscape genetics techniques improve our ability to assess these pathways in natural systems. We address the question to what degree have microrefugial patches and long-distance dispersal been responsible for the colonization of mountain hemlock (Tsuga mertensiana) on the Alaskan Kenai Peninsula...
March 21, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28325485/the-effects-of-interprofessional-education-self-reported-professional-competence-among-prehospital-emergency-care-nursing-students-on-the-point-of-graduation-a-cross-sectional-study
#7
M Castrèn, M Mäkinen, J Nilsson, V Lindström
The aim of the study was to investigate whether interprofessional education (IPE) and interprofessional collaboration (IPC) during the educational program had an impact on prehospital emergency care nurses' (PECN) self-reported competence towards the end of the study program. A cross-sectional study using the Nurse Professional Competence (NPC) Scale was conducted. A comparison was made between PECN students from Finland who experienced IPE and IPC in the clinical setting, and PECN students from Sweden with no IPE and a low level of IPC...
March 16, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28325026/application-of-dti-connectivity-in-lateralization-of-mtle
#8
Mohammad R Nazem-Zadeh, Susan M Bowyer, John E Moran, Esmaeil Davoodi-Bojd, Andrew Zillgitt, Hassan Bagher-Ebadian, Fariborz Mahmoudi, Kost V Elisevich, Hamid Soltanian-Zadeh
Diffusion tensor imaging (DTI) is a noninvasive imaging method for measuring the diffusion properties of the underlying white matter tracts through which epileptiform activity is propagated. This study investigates the structural abnormalities quantified by DTI in mesial temporal lobe epilepsy (mTLE). Fiber tracts passing through 54 anatomical sites in 12 adult mTLE patients and 12 age- and gender-matched controls were identified using DTI tractography. DTI nodal degree (ND) and laterality index were then calculated...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324717/fabrication-of-oriented-wrinkles-on-polydopamine-polystyrene-bilayer-films
#9
Rong Wang, Yuhua Long, Tang Zhu, Jing Guo, Chao Cai, Ning Zhao, Jian Xu
Wrinkles exist widely in nature and our life. In this paper, wrinkles on polydopamine (PDA)/polystyrene (PS) bilayer films were formed by thermal annealing due to the different thermal coefficients of expansion of each layer. The factors that influenced the dimensions of wrinkles were studied. We found that oriented wrinkles could be formed if the bilayer films were patterned with micro-grooves, and the degree of the orientation depended on the thickness of the PDA and the dimensions of the grooves. Combined with the strong adhesion, biocompatibility and reactivity of PDA, the oriented wrinkles on PDA/PS patterned bilayers may find potential application in diffraction gratings, optical sensors and microfluidic devices...
March 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28324666/gene-expression-analysis-to-assess-the-relevance-of-rodent-models-to-human-lung-injury
#10
Timothy E Sweeney, Shane Lofgren, Purvesh Khatri, Angela J Rogers
Rationale The relevance of animal models to human diseases is an area of intense scientific debate. The degree to which mouse models of lung injury recapitulate human lung injury has never been assessed. Integrating data from both human and animal expression studies allows for increased statistical power and identification of conserved differential gene expression across organisms and conditions. Objectives Comprehensive integration of gene expression data in experimental ALI in rodents compared to humans. Methods We performed two separate gene expression multi-cohort analyses to determine differential gene expression in experimental animal and human lung injury...
March 21, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28323709/single-stage-transpedicular-vertebrectomy-and-expandable-cage-placement-for-treatment-of-unstable-mid-and-lower-lumbar-burst-fractures
#11
Jong-Il Choi, Bum-Joon Kim, Sung-Kon Ha, Sang-Dae Kim, Dong-Jun Lim, Se-Hoon Kim
STUDY DESIGN: Retrospective clinical and radiographic study. OBJECTIVE: To examine the efficacy and safety of vertebrectomy and expandable cage placement by a single-stage posterior approach for unstable mid and lower lumbar burst fractures (below the L3). SUMMARY OF BACKGROUND DATA: Patients with unstable mid and lower lumbar burst fractures require surgical treatment to relieve pain, address paralysis, and stabilize the spine to prevent further segmental deformity...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28322743/an-experimental-approach-to-the-immuno-modulatory-basis-of-host-parasite-local-adaptation-in-tapeworm-infected-sticklebacks
#12
Madeleine Hamley, Frederik Franke, Joachim Kurtz, Jörn Peter Scharsack
The evolutionary arms race of hosts and parasites often results in adaptations, which may differ between populations. Investigation of such local adaptation becomes increasingly important to understand dynamics of host-parasite interactions and co-evolution. To this end we performed an infection experiment involving pairs of three-spined sticklebacks and their tapeworm parasite Schistocephalus solidus from three geographically separated origins (Germany, Spain and Iceland) in a fully-crossed design for sympatric and allopatric host/parasite combinations...
March 18, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28322361/effect-of-fluoride-treatments-on-bleached-enamel-microhardness-and-surface-morphology
#13
Dimitrios Dionysopoulos, Eugenia Koliniotou-Koumpia, Kosmas Tolidis, Paris Gerasimou
PURPOSE: To evaluate the effect of three different fluoride treatments on the surface microhardness and morphology of human enamel exposed to two different bleaching agents. MATERIALS AND METHODS: Twenty-three extracted human third molars were sectioned to obtain 90 enamel fragments, mounted on acrylic resin supports, polished and randomly divided into 9 groups (n = 10). The specimens were exposed to a combination of two bleaching agents (22% carbamide peroxide [CP] and 38% hydrogent peroxide [HP]) and three fluoride treatments (0...
March 20, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28322103/segmental-portal-superior-mesenteric-vein-resection-and-reconstruction-with-the-iliac-vein-after-pancreatoduodenectomy
#14
Xin Zhao, Li-Xin Li, Hua Fan, Jian-Tao Kou, Xian-Liang Li, Ren Lang, Qiang He
Objective The results of segmental venous resection (VR) combined with pancreatoduodenectomy (PD) are controversial but may be promising. Few studies have described reconstruction of the portal/superior mesenteric vein (PV/SMV) with the iliac vein harvested from donation after cardiac death (DCD). Methods From January 2014 to April 2016, PD combined with segmental excision of the PV/SMV (VR group) was performed in 21 patients with adenocarcinoma of the head of the pancreas (ADHP). The authors established a new technique of venous reconstruction using the iliac vein from DCD and analysed patients' long-term survival...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28321692/oncologic-outcome-and-quality-of-life-after-hindquarter-amputation-for-sarcoma-is-it-worth-it
#15
Winan J van Houdt, Anthony M Griffin, Jay S Wunder, Peter C Ferguson
BACKGROUND AND OBJECTIVE: Hindquarter amputations for bone or soft tissue sarcoma cause a high degree of disability. The goal of this study was to analyze oncologic outcome and quality of life after resection in order to better select patients who are more likely to benefit from this operation. METHODS: Patients treated with a hindquarter amputation between 1989 and 2015 for a bone or soft tissue sarcoma were selected from our database. Clinical and histopathological features were analyzed for their prognostic value using Kaplan-Meier and Cox proportional hazard analysis...
March 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28320388/exploring-the-fgfr3-related-oncogenic-mechanism-in-bladder-cancer-using-bioinformatics-strategy
#16
Wei Cao, Enguang Ma, Li Zhou, Tan Yuan, Chunying Zhang
BACKGROUND: Aberrant activation of fibroblast growth factor receptor 3 (FGFR3) is frequently observed in bladder cancer, but how it involved in carcinogenesis is not well understood. The current study was aimed to investigate the underlying mechanism on the progression of bladder cancer. METHODS: The GSE41035 dataset downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) between bladder cancer cell line RT112 with or without depletion of FGFR3, and gene ontology enrichment analysis was performed...
March 20, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28320324/quickmirseq-a-pipeline-for-quick-and-accurate-quantification-of-both-known-mirnas-and-isomirs-by-jointly-processing-multiple-samples-from-microrna-sequencing
#17
Shanrong Zhao, William Gordon, Sarah Du, Chi Zhang, Wen He, Li Xi, Sachin Mathur, Michael Agostino, Theresa Paradis, David von Schack, Michael Vincent, Baohong Zhang
BACKGROUND: Genome-wide miRNA expression data can be used to study miRNA dysregulation comprehensively. Although many open-source tools for microRNA (miRNA)-seq data analyses are available, challenges remain in accurate miRNA quantification from large-scale miRNA-seq dataset. We implemented a pipeline called QuickMIRSeq for accurate quantification of known miRNAs and miRNA isoforms (isomiRs) from multiple samples simultaneously. RESULTS: QuickMIRSeq considers the unique nature of miRNAs and combines many important features into its implementation...
March 20, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28319761/dynamic-changes-of-dissolved-organic-matter-in-membrane-bioreactors-at-different-organic-loading-rates-evidence-from-spectroscopic-and-chromatographic-methods
#18
Tahir Maqbool, Jinwoo Cho, Jin Hur
Excitation emission matrix-parallel factor analysis (EEM-PARAFAC) and size exclusion chromatography (SEC) were utilized to explore the dynamics in extracellular polymeric substances (EPS), soluble microbial products (SMP), and effluent for the membrane bioreactors at two different organic loading rates (OLRs). Combination of three different fluorescent components explained the compositional changes of dissolved organic matter. The lower OLR resulted in a higher production of tryptophan-like component (C1) in EPS, while the opposite trends were found for the other two components (humic-like C2 and tyrosine-like C3), signifying the role of C1 in the endogenous condition...
March 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28318531/national-survey-on-postoperative-care-and-treatment-circuits-in-neurosurgery
#19
R Valero, E Carrero, N Fàbregas, F Iturri, N Saiz-Sapena, L Valencia
INTRODUCTION: The analysis of surgical processes should be a standard of health systems. We describe the circuit of care and postoperative treatment for neurosurgical interventions in the centres of our country. MATERIAL AND METHODS: From June to October 2014, a survey dealing with perioperative treatments and postoperative circuits after neurosurgical procedures was sent to the chiefs of Anaesthesiology of 73 Spanish hospitals with neurosurgery and members of the Neuroscience Section of SEDAR...
March 16, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28317954/surface-chemistry-of-pure-tetragonal-zro2-and-gas-phase-dependence-of-the-tetragonal-to-monoclinic-zro2-transformation
#20
Eva-Maria Köck, Michaela Kogler, Thomas Götsch, Lukas Schlicker, Maged F Bekheet, Andrew Doran, Aleksander Gurlo, Bernhard Klötzer, Benedikt Petermüller, Daniel Schildhammer, Nevzat Yigit, Simon Penner
The surface chemical properties of undoped tetragonal ZrO2 and the gas-phase dependence of the tetragonal-to-monoclinic transformation are studied using a tetragonal ZrO2 polymorph synthesized via a sol-gel method from an alkoxide precursor. The obtained phase-pure tetragonal ZrO2 is defective and strongly hydroxylated with pronounced Lewis acidic and Brønsted basic surface sites. Combined in situ FT-infrared and electrochemical impedance measurements reveal effective blocking of coordinatively unsaturated sites by both CO and CO2, as well as low conductivity...
March 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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