Yutang Wang, Owen Sargisson, Dinh Tam Nguyen, Ketura Parker, Stephan J R Pyke, Ahmed Alramahi, Liam Thihlum, Yan Fang, Morgan E Wallace, Stuart P Berzins, Ernesto Oqueli, Dianna J Magliano, Jonathan Golledge
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks...
November 3, 2023: International Journal of Molecular Sciences