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https://www.readbyqxmd.com/read/29325383/-clinical-features-and-surgical-outcomes-of-acute-acquired-comitant-esotropia
#1
M Y Ren, Q Wang, L H Wang
Objective: To investigate the clinical features and surgical outcomes of patients with acute acquired concomitant esotropia (AACE) type Ⅱ(AACE-Ⅱ) and type Ⅲ (AACE-Ⅲ). Methods: Retrospective case series analysis. Medical records of consecutive patients who underwent strabismus surgery for AACE-Ⅱ and AACE-Ⅲ in Shandong Provincial Hospital affiliated to Shandong University between January 2011 and June 2016 with a minimum follow-up time of 3 months were collected. Each patient underwent a complete ophthalmological and orthoptic examination to exclude esotropia resulting from other reasons, and a systemic assessment to exclude AACE related to intracranial and systemic diseases...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29325380/-could-binocular-treatment-be-a-substitute-for-patching
#2
X F Shi, K X Zhao
Amblyopia is a common eye disease with a high prevalence in clinical practice of pediatric ophthalmology and strabismus. The primary treatment strategy for amblyopia is precise correction of refractive errors and patching of the dominant eye. The application of patching has a history of more than 200 years, and now is still the most effective method for treatment of amblyopia. Similar to the principle of traditional patching, atropine penalization has been testified that it can be used as an initial treatment for amblyopia with similar therapeutic effects as patching...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29316906/the-function-of-tcf3-in-medaka-embryos-efficient-knockdown-with-pepnas
#3
Gerlinde Doenz, Sebastian Dorn, Narges Aghaallaei, Baubak Bajoghli, Elisabeth Riegel, Michaela Aigner, Holger Bock, Birgit Werner, Thomas Lindhorst, Thomas Czerny
BACKGROUND: The application of antisense molecules, such as morpholino oligonucleotides, is an efficient method of gene inactivation in vivo. We recently introduced phosphonic ester modified peptide nucleic acids (PNA) for in vivo loss-of-function experiments in medaka embryos. Here we tested novel modifications of the PNA backbone to knockdown the medaka tcf3 gene. RESULTS: A single tcf3 gene exists in the medaka genome and its inactivation strongly affected eye development of the embryos, leading to size reduction and anophthalmia in severe cases...
January 9, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29299788/is-minority-stress-in-the-eye-of-the-beholder-a-test-of-minority-stress-theory-with-christians
#4
Mike C Parent, Melanie E Brewster, Stephen W Cook, Kevin A Harmon
Studies using minority stress theory have focused on the experiences of numerical and social power minorities, though majority individuals may also perceive themselves to be minorities. We explored minority stress theory among a sample of members of a numerically and socially dominant group: Christians in the USA. Perceiving oneself to be a member of a minority as a Christian was associated with stress indirectly via perceived experiences of faith-based discrimination (i.e., harassment due to being Christian)...
January 4, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29299287/diet-reveals-links-between-morphology-and-foraging-in-a-cryptic-temperate-reef-fish
#5
Natalia S Winkler, Maite Paz-Goicoechea, Robert W Lamb, Alejandro Pérez-Matus
Predators select prey so as to maximize energy and minimize manipulation time. In order to reduce prey detection and handling time, individuals must actively select their foraging space (microhabitat) and populations exhibit morphologies that are best suited for capturing locally available prey. We explored how variation in diet correlates with habitat type, and how these factors influence key morphological structures (mouth gape, eye diameter, fin length, fin area, and pectoral fin ratio) in a common microcarnivorous cryptic reef fish species, the triplefin Helcogrammoides cunninghami...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29298970/-ocular-symptoms-in-von-recklinghausen-disease
#6
REVIEW
Mateusz Nowak, Lidia Nowak, Jacek Nowak, Piotr Chaniecki
Von Recklinghausen disease is a genetic disease with autosomal dominant, belonging to the group phakomatoses. In the clinical picture of the disease are skin lesions, eye, bone, intracranial tumors and other cancers of the extracranial location. Due to the high variability of clinical symptoms often diagnosis is delayed in cases of mild expression. The prognosis depends on the location and extent of the change and only symptomatic treatment have a tendency to change regrowth.
December 22, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29298900/cataract-associated-connexin-46-mutation-alters-its-interaction-with-calmodulin-and-function-of-hemichannels
#7
Zhengping Hu, Manuel A Riquelme, Bin Wang, Vladislav Bugay, Robert Brenner, Sumin Gu, Jean X Jiang
Connexin channels help maintain eye lens homeostasis and transparency. The G143R missense substitution in connexin (Cx) 46 is associated with congenital Coppock cataracts; however, the underlying molecular mechanism is largely unknown. Here, we report that compared with wild type (WT) Cx46, the G143R substitution abolishes hemichannel conductance in Xenopus oocytes and in HeLa cells. Moreover, this substitution is dominant-negative and inhibits conductance of WT Cx46. CD analysis indicated that the substitution greatly reduces the α-helical structure of the intracellular Cx46 loop domain...
January 3, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29289973/neurological-and-neuropsychological-complications-in-the-course-of-chronic-whipple-s-disease-case-report
#8
Izabela Dymon, Justyna Tabaka-Pradela, Katarzyna Anna Knast, Dominika Dudek, Monika Rudzińska
INTRODUCTION: Whipple's disease (WD) is a chronic, multisystemic infectious disease caused by Gram-positive bacillus Tropheryma whipplei (T.w.). Its common symptoms arise in the digestive system, however, during the infection the CNS (Central Nervous System) may also be affected. AIM: The aim of this work is to present a case report of a patient diagnosed with Whipple's disease with dominant neuropsychological and behavioural complications in the late phase. CONCLUSIONS: Whipple's disease is a rare disease with possible neurological and neuropsychiatric complications...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29282836/geometric-patterns-of-time-delay-plots-from-different-cardiac-rhythms-and-arrhythmias-using-short-term-ekg-signals
#9
Raúl A Borracci, José D Montoya Pulvet, Carlos A Ingino, Mario Fitz Maurice, Alfredo Hirschon Prado, Enrique Dominé
OBJECTIVE: To date, no systematic work has been intended to describe spatio-temporal patterns of cardiac rhythms using only short series of RR intervals, to facilitate visual or computerized-aided identification of EKG motifs for use in clinical practice. The aim of this study was to detect and classify eye-catching geometric patterns of Poincaré time-delay plots from different types of cardiac rhythms and arrhythmias using short-term EKG signals. METHODS: Approximately 150-300 representative, consecutive beats were retrieved from 24-h Holter registers of 100 patients with different heart rhythms...
December 27, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29281027/cas9-sgrna-selective-targeting-of-the-p23h-rhodopsin-mutant-allele-for-treating-retinitis-pigmentosa-by-intravitreal-aav9-php-b-based-delivery
#10
Serena G Giannelli, Mirko Luoni, Valerio Castoldi, Luca Massimino, Tommaso Cabassi, Debora Angeloni, Giancarlo Demontis, Letizia Leocani, Massimiliano Andreazzoli, Vania Broccoli
P23H is the most common mutation in the RHODOPSIN (RHO) gene leading to a dominant form of Retinitis Pigmentosa (RP), a rod photoreceptor degeneration that invariably causes vision loss. Specific disruption of the disease P23H RHO mutant while preserving the wild-type functional allele would be an invaluable therapy for this disease. However, various technologies tested in the past failed to achieve effective changes and consequently therapeutic benefits. We validated a CRISPR/Cas9 strategy to specifically inactivate the P23H RHO mutant, while preserving the wild-type (WT) allele in vitro...
December 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29279026/cortical-visual-connections-via-the-corpus-callosum-are-asymmetrical-in-human-infantile-esotropia
#11
Marcel P M Ten Tusscher, Anne Cees Houtman, Johan De Mey, Peter Van Schuerbeek
PURPOSE: Besides chiasmal hemidecussation, interhemispheric connections are likely important in human binocularity. The corpus callosum (CC) is the major fiber bundle in the mammalian brain which mostly connects homologous cortical areas in the two hemispheres. Visual interhemispheric connections were found abnormal in strabismic cats. No studies have investigated these pathways in humans with infantile strabismus. METHODS: Diffusion tensor imaging was used in four subjects with infantile esotropia (IE) and nine control subjects with normal binocularity, in order to study interhemispheric fibers in the CC connecting the right and left primary visual cortical areas...
December 26, 2017: Strabismus
https://www.readbyqxmd.com/read/29261660/genetic-analysis-of-japanese-primary-open-angle-glaucoma-patients-and-clinical-characterization-of-risk-alleles-near-cdkn2b-as1-six6-and-gas7
#12
Yukihiro Shiga, Koji M Nishiguchi, Yosuke Kawai, Kaname Kojima, Kota Sato, Kosuke Fujita, Mai Takahashi, Kazuko Omodaka, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Nobuo Fuse, Masayuki Yamamoto, Jun Yasuda, Masao Nagasaki, Toru Nakazawa
PURPOSE: To test the genetic association between Japanese patients with primary open-angle glaucoma (POAG) and the previously reported POAG susceptibility loci and to perform genotype-phenotype analysis. METHODS: Genetic associations for 27 SNPs from 16 loci previously linked to POAG were assessed using genome-wide SNP data of the primary cohort (565 Japanese POAG patients and 1,104 controls). Reproducibility of the assessment was tested in 607 POAG cases and 455 controls (second cohort) with a targeted genotyping approach...
2017: PloS One
https://www.readbyqxmd.com/read/29259299/two-novel-mutations-identified-in-adcc-families-impair-crystallin-protein-distribution-and-induce-apoptosis-in-human-lens-epithelial-cells
#13
Li Li, Da-Bei Fan, Ya-Ting Zhao, Yun Li, De-Qian Kong, Fang-Fei Cai, Guang-Ying Zheng
Congenital cataract (CC) is a clinical and genetically heterogeneous eye disease that primarily causes lens disorder and even amblyopic blindness in children. As the mechanism underlying CC is genetically inherited, identification of CC-associated gene mutations and their role in protein distribution are topics of both pharmacological and biological research. Through physical and ophthalmic examinations, two Chinese pedigrees with autosomal dominant congenital cataract (ADCC) were recruited for this study. Mutation analyses of CC candidate genes by next-generation sequencing (NGS) and Sanger sequencing revealed a novel missense mutation in CRYBB2 (p...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29243736/a-novel-missense-mutation-in-hsf4-causes-autosomal-dominant-congenital-lamellar-cataract-in-a-british-family
#14
V Berry, N Pontikos, A Moore, A C W Ionides, V Plagnol, M E Cheetham, M Michaelides
PurposeInherited cataract, opacification of the lens, is the most common worldwide cause of blindness in children. We aimed to identify the genetic cause of isolated autosomal-dominant lamellar cataract in a five-generation British family.MethodsWhole exome sequencing (WES) was performed on two affected individuals of the family and further validated by direct sequencing in family members.ResultsA novel missense mutation NM_001040667.2:c.190A>G;p.K64E was identified in the DNA-binding-domain of heat-shock transcription factor 4 (HSF4) and found to co-segregate with disease...
December 15, 2017: Eye
https://www.readbyqxmd.com/read/29242902/effects-of-prenatal-alcohol-exposure-on-the-visual-system-of-monkeys-measured-at-different-stages-of-development
#15
Vanessa Harrar, Laurent Elkrief, Joseph Bouskila, Ryan Kucera, Anders Fink-Jensen, Jean-François Bouchard, Roberta Palmour, Maurice Ptito
Purpose: Fetal alcohol spectrum disorder (FASD) is a developmental disease characterized by behavioral problems and physical defects including malformations of the eye and associated optical defects. How these malformations affect retinal functioning is not well known, although animal models have suggested that scotopic vision is particularly deficient. Age is also known to affect scotopic vision. Here, we determined the combined effects of age and fetal alcohol exposure (FAE) on retinal function using full-field electroretinograms (ERGs) in monkeys (Chlorocebus sabaeus)...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29240758/increased-gamma-band-activity-for-lateral-interactions-in-humans
#16
Alon Shapira, Anna Sterkin, Moshe Fried, Oren Yehezkel, Zeev Zalevsky, Uri Polat
Collinear facilitation of contrast sensitivity supported by lateral interactions within primary visual cortex is implicated in contour and object perception, with neural correlates in several frequency bands. Although higher component of the ERP power spectrum, the gamma-band, is postulated to reflect object representation, attention and memory, its neuronal source has been questioned, suggesting it is an artifact reflecting saccadic eye movements. Here we explored the gamma-band activity during collinear facilitation with no saccade-related confounds...
2017: PloS One
https://www.readbyqxmd.com/read/29238296/the-effects-of-rtms-combined-with-motor-training-on-functional-connectivity-in-alpha-frequency-band
#17
Jing-Na Jin, Xin Wang, Ying Li, Fang Jin, Zhi-Peng Liu, Tao Yin
It has recently been reported that repetitive transcranial magnetic stimulation combined with motor training (rTMS-MT) could improve motor function in post-stroke patients. However, the effects of rTMS-MT on cortical function using functional connectivity and graph theoretical analysis remain unclear. Ten healthy subjects were recruited to receive rTMS immediately before application of MT. Low frequency rTMS was delivered to the dominant hemisphere and non-dominant hand performed MT over 14 days. The reaction time of Nine-Hole Peg Test and electroencephalography (EEG) in resting condition with eyes closed were recorded before and after rTMS-MT...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29232704/do-early-neural-correlates-of-visual-consciousness-show-the-oblique-effect-a-binocular-rivalry-and-event-related-potential-study
#18
Bradley N Jack, Urte Roeber, Robert P O'Shea
When dissimilar images are presented one to each eye, we do not see both images; rather, we see one at a time, alternating unpredictably. This is called binocular rivalry, and it has recently been used to study brain processes that correlate with visual consciousness, because perception changes without any change in the sensory input. Such studies have used various types of images, but the most popular have been gratings: sets of bright and dark lines of orthogonal orientations presented one to each eye. We studied whether using cardinal rival gratings (vertical, 0°, and horizontal, 90°) versus oblique rival gratings (left-oblique, -45°, and right-oblique, 45°) influences early neural correlates of visual consciousness, because of the oblique effect: the tendency for visual performance to be greater for cardinal gratings than for oblique gratings...
2017: PloS One
https://www.readbyqxmd.com/read/29232624/genomic-form-of-rhodopsin-dna-nanoparticles-rescued-autosomal-dominant-retinitis-pigmentosa-in-the-p23h-knock-in-mouse-model
#19
Rajendra Narayan Mitra, Min Zheng, Ellen R Weiss, Zongchao Han
Retinitis pigmentosa (RP) is a group of inherited retinal degenerative conditions and a leading cause of irreversible blindness. 25%-30% of RP cases are caused by inherited autosomal dominant (ad) mutations in the rhodopsin (Rho) protein of the retina, which impose a barrier for developing therapeutic treatments for this genetically heterogeneous disorder, as simple gene replacement is not sufficient to overcome dominant disease alleles. Previously, we have explored using the genomic short-form of Rho (sgRho) for gene augmentation therapy of RP in a Rho knockout mouse model...
December 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/29229707/the-primary-role-of-flow-processing-in-the-identification-of-scene-relative-object-movement
#20
Simon K Rushton, Diederick C Niehorster, Paul A Warren, Li Li
Retinal image motion could be due to movement of the observer through space or an object relative to the scene. Optic flow, form, and change of position cues all provide information that could be used to separate out retinal motion due to object movement from retinal motion due to observer movement. In Experiment 1 we used a minimal display to examine the contribution of optic flow and form cues. Human participants indicated the direction of movement of a probe object presented against a background of radially moving pairs of dots...
December 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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