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https://www.readbyqxmd.com/read/27899890/causal-role-of-thalamic-interneurons-in-brain-state-transitions-a-study-using-a-neural-mass-model-implementing-synaptic-kinetics
#1
Basabdatta Sen Bhattacharya, Thomas P Bond, Louise O'Hare, Daniel Turner, Simon J Durrant
Experimental studies on the Lateral Geniculate Nucleus (LGN) of mammals and rodents show that the inhibitory interneurons (IN) receive around 47.1% of their afferents from the retinal spiking neurons, and constitute around 20-25% of the LGN cell population. However, there is a definite gap in knowledge about the role and impact of IN on thalamocortical dynamics in both experimental and model-based research. We use a neural mass computational model of the LGN with three neural populations viz. IN, thalamocortical relay (TCR), thalamic reticular nucleus (TRN), to study the causality of IN on LGN oscillations and state-transitions...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27898980/feasibility-of-macular-integrity-assessment-maia-microperimetry-in-children-sensitivity-reliability-and-fixation-stability-in-healthy-observers
#2
Pete R Jones, Narmella Yasoubi, Marko Nardini, Gary S Rubin
Purpose: To assess the feasibility of macular integrity assessment (MAIA) microperimetry (MP) in children. Also to establish representative outcome measures (differential light sensitivity, fixation stability, test-retest reliability) for children without visual impairment. Methods: Thirty-three adults and 33 children (9-12 years) were asked to perform three monocular MAIA examinations within a single session (dominant eye only). Results: Children exhibited poorer test-retest reliability than adults for measures of both mean sensitivity (95% coefficient of repeatability [CoR95] = 2...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27898814/software-for-genome-wide-association-studies-in-autopolyploids-and-its-application-to-potato
#3
Umesh R Rosyara, Walter S De Jong, David S Douches, Jeffrey B Endelman
Genome-wide association studies (GWAS) are widely used in diploid species to study complex traits in diversity and breeding populations, but GWAS software tailored to autopolyploids is lacking. The objectives of this research were to (i) develop an R package for autopolyploids based on the + mixed model, (ii) validate the software with simulated data, and (iii) analyze a diversity panel of tetraploid potatoes. A unique feature of the R package, called GWASpoly, is its ability to model different types of polyploid gene action, including additive, simplex dominant, and duplex dominant...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27894921/alterations-of-awake-eeg-in-idiopathic-rem-sleep-behavior-disorder-without-cognitive-impairment
#4
Young Rong Bang, Hong Jun Jeon, Soyoung Youn, In-Young Yoon
The aim of this study was to find electroencephalographic (EEG) changes in subjects with drug-naïve idiopathic rapid eye movement sleep behavior disorder (iRBD) who had no cognitive impairment. A total of 57 iRBD patients confirmed by polysomnography (PSG) and 33 sex and age-matched healthy controls were included and their waking EEG was recorded from five cortical regions for 15minutes. Power spectral analyses by fast Fourier transforms were performed on EEG data. In PSG data, the iRBD patients showed sleep disturbances of short total sleep time, decreased sleep efficiency, increased sleep latency and frequent awakening compared to controls...
November 25, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27886711/eeg-epochs-with-less-alpha-rhythm-improve-discrimination-of-mild-alzheimer-s
#5
Paulo A M Kanda, Eliezyer F Oliveira, Francisco J Fraga
BACKGROUND AND OBJECTIVE: Eyes-closed-awake electroencephalogram (EEG) is a useful tool in the diagnosis of Alzheimer's. However, there is eyes-closed-awake EEG with dominant or rare alpha rhythm. In this paper, we show that random selection of EEG epochs disregarding the alpha rhythm will lead to bias concerning EEG-based Alzheimer's Disease diagnosis. METHODS: We compared EEG epochs with more than 30% and with less than 30% alpha rhythm of mild Alzheimer's Disease patients and healthy elderly...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27886254/two-novel-mutations-in-prpf3-causing-autosomal-dominant-retinitis-pigmentosa
#6
Zilin Zhong, Min Yan, Wan Sun, Zehua Wu, Liyun Han, Zheng Zhou, Fang Zheng, Jianjun Chen
Retinitis pigmentosa (RP) is a heterogeneous set of hereditary eye diseases, characterized by selective death of photoreceptor cells in the retina, resulting in progressive visual impairment. Approximately 20-40% of RP cases are autosomal dominant RP (ADRP). In this study, a Chinese ADRP family previously localized to the region between D1S2819 and D1S2635 was sequenced via whole-exome sequencing and a variant c.1345C > G (p.R449G) was identified in PRPF3. The Sanger sequencing was performed in probands of additional 95 Chinese ADRP families to investigate the contribution of PRPF3 to ADRP in Chinese population and another variant c...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876559/non-dominant-hand-quicker-to-insert-peripheral-venous-catheters-under-echographic-guidance-a-randomized-trial
#7
Lucas Durand-Bailloud, Ludwig-Serge Aho, Georges Savoldelli, Fiona Ecarnot, Claude Girard, Mehdi Benkhadra
BACKGROUND: Ultrasound guidance for venous catheter placement requires the use of both hands. An accurate and stable ultrasound image is fundamental for obtaining good quality images, consequently permitting accurate needle placement. We hypothesized that the dominant hand could be used to perform echography, leaving the non-dominant hand available for peripheral venous catheter (PVC) insertion. METHODS: Prospective, open-label, randomized, crossover study. Group 1 inserted the PVC with the dominant hand, and held the probe with the non-dominant hand in a first series of 20 insertions, and vice-versa in a second series of 20 insertions performed 11 days later...
November 19, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27867729/binocular-summation-and-visual-function-with-induced-anisocoria-and-monovision
#8
José J Castro, Margarita Soler, Carolina Ortiz, José R Jiménez, Rosario G Anera
The advances in new techniques for correcting presbyopia, such as a small aperture combined with monovision, require an in-depth study of binocular aspects. In this work, we have studied binocular visual performance of 12 subjects after inducing different degrees of anisocoria combined with two different add powers in the non-dominant eye. We have analysed visual performance in terms of the visual-discrimination capacity (a function to evaluate the strength of bothersome halos) and the contrast-sensitivity...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27858935/multiethnic-involvement-in-autosomal-dominant-optic-atrophy-in-singapore
#9
J L Loo, S Singhal, A V Rukmini, S Tow, P Amati-Bonneau, V Procaccio, D Bonneau, J J Gooley, P Reynier, M Ferré, D Milea
PurposeAutosomal-dominant optic atrophy (ADOA), often associated with mutations in the OPA1 gene (chromosome 3q28-q29) is rarely reported in Asia. Our aim was to identify and describe this condition in an Asian population in Singapore.Patients and methodsPreliminary cross-sectional study at the Singapore National Eye Centre, including patients with clinical suspicion of ADOA, who subsequently underwent genetic testing by direct sequencing of the OPA1 gene.ResultsAmong 12 patients (10 families) with clinically suspected ADOA, 7 patients (5 families) from 3 different ethnic origins (Chinese, Indian, and Malay) carried a heterozygous pathogenic variant in the OPA1 gene...
November 18, 2016: Eye
https://www.readbyqxmd.com/read/27857755/can-long-term-thiamine-treatment-improve-the-clinical-outcomes-of-myotonic-dystrophy-type-1
#10
Antonio Costantini, Erika Trevi, Maria Immacolata Pala, Roberto Fancellu
Myotonic dystrophy type 1, also known as Steinert's disease, is an autosomal dominant disorder with multisystemic clinical features affecting the skeletal and cardiac muscles, the eyes, and the endocrine system. Thiamine (vitamin B1) is a cofactor of fundamental enzymes involved in the energetic cell metabolism; recent studies described its role in oxidative stress, protein processing, peroxisomal function, and gene expression. Thiamine deficiency is critical mainly in the central and peripheral nervous system, as well as in the muscular cells...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27857701/processing-and-representation-of-ambiguous-words-in-chinese-reading-evidence-from-eye-movements
#11
Wei Shen, Xingshan Li
In the current study, we used eye tracking to investigate whether senses of polysemous words and meanings of homonymous words are represented and processed similarly or differently in Chinese reading. Readers read sentences containing target words which was either homonymous words or polysemous words. The contexts of text preceding the target words were manipulated to bias the participants toward reading the ambiguous words according to their dominant, subordinate, or neutral meanings. Similarly, disambiguating regions following the target words were also manipulated to favor either the dominant or subordinate meanings of ambiguous words...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27852401/-distribution-and-compensation-mechanism-of-aberrations-between-anterior-and-posterior-surface-of-the-cornea-in-myopia-and-myopic-astigmatism-eyes
#12
X J Li, Y Wang, Y N Wu, W J Wu, C J Yu, L L Xu
Objective: To study the compensation mechanism of aberrations between anterior and posterior corneal surface, and to investigate the correlations between corneal aberrations and K values, intraocular pressure and central corneal thickness. Methods: One hundred and sixty-one subjects (300 eyes) with myopia and myopic astigmatism were recruited randomly. Corneal aberrations (anterior, posterior and total) in three different optical zones (2 mm, 4 mm, and 6 mm) centered on the corneal vertex were assessed with a corneal topographer (Sirius)...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27843908/anterior-chamber-pathology-in-alagille-syndrome
#13
Derek K Ho, Alex V Levin, William V Anninger, David A Piccoli, Ralph C Eagle
BACKGROUND: Alagille syndrome is an autosomal dominant disorder characterized by neonatal cholestasis, characteristic facies, and cardiac abnormalities. Ocular abnormalities include posterior embryotoxon, mosaic pattern of iris stromal hypoplasia, microcornea, optic disc drusen, and pigmentary retinopathy. We present the second report of ocular pathology in two cases of Alagille syndrome. METHODS: Gross and histologic preparations of four eyes of two patients. RESULTS: Posterior embryotoxon is seen in both cases, with iris processes extending to the embryotoxon in case 1...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27833926/bilateral-papilledema-in-a-child-with-osteogenesis-imperfecta
#14
Selam Yekta Sendul, Cemile Ucgul Atilgan, Semra Tiryaki, Dilek Guven
BACKGROUND: To present a female child patient with osteogenesis imperfecta who had bilateral papilledema. CASE PRESENTATION: A twelve-year-old girl with osteogenesis imperfecta was referred to our clinic. Bilateral best corrected visual acuity of the patient was 5/10 (corrected with +3.50 for right eye, +5.00 for left eye) with a standard Snellen scale at a distance of a 6 m. Anterior chamber, iris and lens examination of both of her eyes were unremarkable. In her fundus examination, bilateral stage 2 papilledema and the wrinkles in papillomacular area were noticed...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27830199/qualitative-evaluation-of-anterior-segment-in-angle-closure-disease-using-anterior-segment-optical-coherence-tomography
#15
Sasan Moghimi, Rebecca Chen, Nikoo Hamzeh, Nassim Khatibi, Shan C Lin
PURPOSE: To evaluate different mechanisms of primary angle closure (PAC) and to quantify anterior chamber (AC) parameters in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT). METHODS: In this prospective study, 115 eyes of 115 patients with angle closure disease were included and categorized into three groups: 1) fellow eyes of acute angle closure (AAC; 40 eyes); 2) primary angle closure glaucoma (PACG; 39 eyes); and 3) primary angle closure suspect (PACS; 36 eyes)...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27826181/analysis-of-the-association-between-the-lum-rs3759223-variant-and-high-myopia-in-a-japanese-population
#16
Shintaro Okui, Akira Meguro, Masaki Takeuchi, Takahiro Yamane, Eiichi Okada, Yasuhito Iijima, Nobuhisa Mizuki
PURPOSE: Many studies have investigated the relationship of the lumican gene (LUM) rs3759223 variant with the risk of high myopia, but the results have been inconsistent and inconclusive. In this study, we investigated whether LUM rs3759223 is associated with high myopia in a Japanese population. METHODS: We recruited 1,585 Japanese patients with high myopia (spherical equivalent [SE] <-9.00 diopters [D]) and 1,011 Japanese healthy controls (SE ≥-1.00 D). The rs3759223 variant was genotyped using the TaqMan assay, and the allelic and genotypic diversity among cases and controls was analyzed according to the SE level...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27824897/functional-plasticity-after-unilateral-vestibular-midbrain-infarction-in-human-positron-emission-tomography
#17
Sandra Becker-Bense, Hans-Georg Buchholz, Bernhard Baier, Mathias Schreckenberger, Peter Bartenstein, Andreas Zwergal, Thomas Brandt, Marianne Dieterich
The aim of the study was to uncover mechanisms of central compensation of vestibular function at brainstem, cerebellar, and cortical levels in patients with acute unilateral midbrain infarctions presenting with an acute vestibular tone imbalance. Eight out of 17 patients with unilateral midbrain infarctions were selected on the basis of signs of a vestibular tone imbalance, e.g., graviceptive (tilts of perceived verticality) and oculomotor dysfunction (skew deviation, ocular torsion) in F18-fluordeoxyglucose (FDG)-PET at two time points: A) in the acute stage, and B) after recovery 6 months later...
2016: PloS One
https://www.readbyqxmd.com/read/27824376/changes-to-corneal-aberrations-and-vision-after-monovision-in-patients-with-hyperopia-after-using-a-customized-aspheric-ablation-profile-to-increase-corneal-asphericity-q-factor
#18
Romain Courtin, Alain Saad, Alice Grise-Dulac, Emmanuel Guilbert, Damien Gatinel
PURPOSE: To evaluate the visual outcomes and fourth-order Zernike spherical aberrations induced with a customized change in corneal asphericity (ΔQ) correction of presbyopia combined with monovision for hyperopic patients. METHODS: Consecutive hyperopic patients who underwent presbyopic LASIK between September 2013 and July 2014 were included. For the non-dominant eyes, the aspheric ablation profile associated with a myopic refraction was planned using the Custom-Q nomogram (Alcon Laboratories, Inc...
November 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27821969/mahjong-playing-and-eye-hand-coordination-in-older-adults-a-cross-sectional-study
#19
William W N Tsang, Gloria C K Wong, Kelly L Gao
[Purpose] Eye-hand coordination declines with age, but physical activity is known to slow down the degeneration. Playing mahjong involves lots of eye-hand coordination. The objective was to investigate the relationship between playing mahjong and eye-hand coordination in older adults using a fast finger-pointing paradigm. [Subjects and Methods] Forty-one community dwelling older adults aged sixty or above were recruited by convenience sampling in this cross-sectional study. They were tested on their ability to point quickly and accurately 1) toward a stationary visual target and 2) toward a moving visual target...
October 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27817779/-identification-of-a-novel-jag1-mutation-in-a-family-affected-by-alagille-syndrome
#20
Ying Cheng, Shu-Tao Zhao, Li Guo, Mei Deng, Qing Zhou, Yuan-Zong Song
Alagille syndrome (ALGS) is an autosomal dominant disorder which is mainly caused by JAG1 gene mutation and can affect multiple systems including the liver, heart, eyes, skeleton and face. This paper reports the clinical and genetic features of an ALGS patient. A 2-year-and-9-month-old boy was referred to the hospital with the complaint of abnormal liver function and heart murmur discovered over two years. Jaundice of the skin and sclera was not observed. The child had a prominent forehead, left esotropia, depressed nasal bridge and micromandible...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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