Patrick H Dessein, Raquel Lopez-Mejias, Begona Ubilla, Fernanda Genre, Alfonso Corrales, Jose L Hernandez, Ivan Ferraz-Amaro, Linda Tsang, Trinitario Pina, Javier Llorca, Ricardo Blanco, Carlos Gonzalez-Juanatey, Miguel A Gonzalez-Gay
OBJECTIVES: We examined the association of TNF-related apoptosis-inducing ligand (TRAIL) concentrations with cardiovascular disease (CVD) in rheumatoid arthritis (RA) and, since osteoprotegerin (OPG) can act as a decoy receptor for TRAIL, whether TRAIL concentrations impact on the OPG level-atherosclerotic CVD relation that was recently documented in the present cohort. METHODS: TRAIL concentrations were assessed by ELISA in 151 RA patients of which 75 (49.7%) had CVD comprising ischaemic heart disease (n=27), cerebrovascular accident (n=26), peripheral artery disease (n=9) or/and heart failure (HF) (n=27), and 62 controls...
July 2015: Clinical and Experimental Rheumatology