Natalie Matosin, Janine Arloth, Darina Czamara, Katrina Z Edmond, Malosree Maitra, Anna S Fröhlich, Silvia Martinelli, Dominic Kaul, Rachael Bartlett, Amber R Curry, Nils C Gassen, Kathrin Hafner, Nikola S Müller, Karolina Worf, Ghalia Rehawi, Corina Nagy, Thorhildur Halldorsdottir, Cristiana Cruceanu, Miriam Gagliardi, Nathalie Gerstner, Maik Ködel, Vanessa Murek, Michael J Ziller, Elizabeth Scarr, Ran Tao, Andrew E Jaffe, Thomas Arzberger, Peter Falkai, Joel E Kleinmann, Daniel R Weinberger, Naguib Mechawar, Andrea Schmitt, Brian Dean, Gustavo Turecki, Thomas M Hyde, Elisabeth B Binder
Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric patients, with potential to be leveraged as a therapeutic target for these individuals. While it is widely reported that FKBP5/FKBP51 mRNA/protein (FKBP5/1) expression is impacted by psychiatric disease state, risk genotype and age, it is not known in which cell types and sub-anatomical areas of the human brain this occurs...
April 2023: Acta Neuropathologica