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https://www.readbyqxmd.com/read/27458249/gene-expression-analysis-reveals-the-concurrent-activation-of-proapoptotic-and-antioxidant-defensive-mechanisms-in-flavokawain-b-treated-cervical-cancer-hela-cells
#1
Swee Keong Yeap, Nadiah Abu, Nadeem Akthar, Wan Yong Ho, Huynh Ky, Sheau Wei Tan, Noorjahan Banu Alitheen, Tunku Kamarul
Flavokawain B (FKB) is known to possess promising anticancer abilities. This is demonstrated in various cancer cell lines including HeLa cells. Cervical cancer is among the most widely diagnosed cancer among women today. Though FKB has been shown to be effective in treating cancer cells, the exact molecular mechanism is still unknown. This study is aimed at understanding the effects of FKB on HeLa cells using a microarray-based mRNA expression profiling and proteome profiling of stress-related proteins. The results of this study suggest that FKB induced cell death through p21-mediated cell cycle arrest and activation of p38...
July 24, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27453978/body-image-perception-in-acromegaly-is-not-associated-with-objective-acromegalic-changes-but-depends-on-depressive-symptoms
#2
Christina Dimopoulou, Sarah M Leistner, Marcus Ising, Harald J Schneider, Jochen Schopohl, Sandra Rutz, Robert Kosilek, Richard Frohner, Gunter K Stalla, Caroline Sievers
OBJECTIVE: Diagnosis of acromegaly is delayed up to 10 years after disease onset despite obvious external/objective changes such as bone and soft-tissue deformities. We hypothesized that a lack of subjective perception of the disease state, possibly mediated by psychiatric or cognitive alterations, might contribute to the delayed initiation of a diagnostic work-up. DESIGN: Cross-sectional study. METHODS: We investigated perceived body image by standardized questionnaires (FKB-20: Fragebogen zum Körperbild; FBeK: Fragebogen zur Beurteilung des eigenen Körpers) in 81 acromegalic patients and contrasted them to a) a clinical control group of 60 patients with non-functioning pituitary adenomas (NFPA) who lack severe facial and physical alterations and b) healthy controls...
July 25, 2016: Neuroendocrinology
https://www.readbyqxmd.com/read/27357227/target-genes-of-the-streptomyces-tsukubaensis-fkbn-regulator-include-most-of-the-tacrolimus-biosynthesis-genes-a-phosphopantetheinyl-transferase-and-other-pks-genes
#3
María Ordóñez-Robles, Antonio Rodríguez-García, Juan F Martín
Tacrolimus (FK506) is a 23-membered macrolide immunosuppressant used in current clinics. Understanding how the tacrolimus biosynthetic gene cluster is regulated is important to increase its industrial production. Here, we analysed the effect of the disruption of fkbN (encoding a LAL-type positive transcriptional regulator) on the whole transcriptome of the tacrolimus producer Streptomyces tsukubaensis using microarray technology. Transcription of fkbN in the wild type strain increases from 70 h of cultivation reaching a maximum at 89 h, prior to the onset of tacrolimus biosynthesis...
September 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27314841/12-month-intravascular-ultrasound-observations-from-bioss%C3%A2-first-in-man-studies
#4
Robert J Gil, Jacek Bil, Ricardo A Costa, Katarzyna E Gil, Dobrin Vassiliev
The aim of this study was to analyze the difference in neointima pattern assessed by intravascular ultrasound (IVUS) between two dedicated bifurcation stents, BiOSS® Expert and BiOSS® LIM at 12-month follow-up. This manuscript reports IVUS findings obtained from the analysis of patients enrolled into first-in-man registries initially assessing the BiOSS Expert® (paclitaxel) and BiOSS LIM® (sirolimus) stents. Quantitative angiographic analysis was performed pre, post-stenting, and at follow-up. IVUS examination was performed at 12 months...
June 17, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/26922065/flavokawain-b-induced-cytotoxicity-in-two-breast-cancer-cell-lines-mcf-7-and-mda-mb231-and-inhibited-the-metastatic-potential-of-mda-mb231-via-the-regulation-of-several-tyrosine-kinases-in-vitro
#5
Nadiah Abu, M Nadeem Akhtar, Swee Keong Yeap, Kian Lam Lim, Wan Yong Ho, Mohd Puad Abdullah, Chai Ling Ho, Abdul Rahman Omar, Jamil Ismail, Noorjahan Banu Alitheen
BACKGROUND: The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated. METHOD: Several in vitro assays were attempted such as MTT, flow cytometry of cell cycle analysis, annexin V analysis, and JC-1 analysis to detect apoptosis...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26789234/flavokawains-a-and-b-from-kava-piper-methysticum-activate-heat-shock-and-antioxidant-responses-and-protect-against-hydrogen-peroxide-induced-cell-death-in-hepg2-hepatocytes
#6
Keanu D Pinner, Christina T K Wales, Rachel A Gristock, Hoa T Vo, Nadine So, Aaron T Jacobs
Context Flavokawains are secondary metabolites from the kava plant (Piper methysticum Forst. f., Piperaceae) that have anticancer properties and demonstrated oral efficacy in murine cancer models. However, flavokawains also have suspected roles in rare cases of kava-induced hepatotoxicity. Objective To compare the toxicity flavokawains A and B (FKA, FKB) and monitor the resulting transcriptional responses and cellular adaptation in the human hepatocyte cell line, HepG2. Materials and methods HepG2 were treated with 2-100 μM FKA or FKB for 24-48 h...
September 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26418576/rna-seq-reveals-acute-manganese-exposure-increases-endoplasmic-reticulum-related-and-lipocalin-mrnas-in-caenorhabditis-elegans
#7
Martina Rudgalvyte, Juhani Peltonen, Merja Lakso, Richard Nass, Garry Wong
Manganese (Mn) is an essential nutrient; nonetheless, excessive amounts can accumulate in brain tissues causing manganism, a severe neurological condition. Previous studies have suggested oxidative stress, mitochondria dysfunction, and impaired metabolism pathways as routes for Mn toxicity. Here, we used the nematode Caenorhabditis elegans to analyze gene expression changes after acute Mn exposure using RNA-Seq. L1 stage animals were exposed to 50 mM MnCl2 for 30 min and analyzed at L4. We identified 746 up- and 1828 downregulated genes (FDR corrected p < 0...
February 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/26315732/long-term-clinical-outcomes-of-final-kissing-ballooning-in-coronary-bifurcation-lesions-treated-with-the-1-stent-technique-results-from-the-cobis-ii-registry-korean-coronary-bifurcation-stenting-registry
#8
MULTICENTER STUDY
Cheol Woong Yu, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Hyun Jong Lee, Ju Hyeon Oh, Bon-Kwon Koo, Seung Woon Rha, Jin-Ok Jeong, Myung-Ho Jeong, Jung Han Yoon, Yangsoo Jang, Seung-Jea Tahk, Hyo-Soo Kim, Hyeon-Cheol Gwon
OBJECTIVES: This study investigated the impact of final kissing ballooning (FKB) after main vessel (MV) stenting on outcomes in patients with coronary bifurcation lesions after application of the 1-stent technique. BACKGROUND: Although FKB has been established as the standard method for bifurcation lesions treated with a 2-stent strategy, its efficacy in a 1-stent approach is highly controversial. METHODS: This study enrolled 1,901 patients with a bifurcation lesion with a side branch diameter ≥2...
August 24, 2015: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26123050/biotransformation-of-flavokawains-a-b-and-c-chalcones-from-kava-piper-methysticum-by-human-liver-microsomes
#9
Katharina Zenger, Sara Agnolet, Bernd Schneider, Birgit Kraus
The in vitro metabolism of flavokawains A, B, and C (FKA, FKB, FKC), methoxylated chalcones from Piper methysticum, was examined using human liver microsomes. Phase I metabolism and phase II metabolism (glucuronidation) as well as combined phase I+II metabolism were studied. For identification and structure elucidation of microsomal metabolites, LC-HRESIMS and NMR techniques were applied. Major phase I metabolites were generated by demethylation in position C-4 or C-4' and hydroxylation predominantly in position C-4, yielding FKC as phase I metabolite of FKA and FKB, helichrysetin as metabolite of FKA and FKC, and cardamonin as metabolite of FKC...
July 22, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25919059/-validation-of-the-essen-quality-of-life-index-for-eating-disorders-eli
#10
Sefik Tagay, Marion Lindner, Hans-Christoph Friederich, Ellen Schlottbohm
The aim of this study was the validation of a short disease-specific questionnaire (ELI, Essen Quality of Life Index for Eating Disorders) to measure the health-related quality of life in patients with eating disorders. A total of 182 currently ill and former eating disordered patients and 87 healthy controls completed the ELI questionnaire as well as other reliable and valid instruments (EDQOL, SF-12, EDI-2, FKB-20, SEED, BSI, IIP-D and SOC-13). In addition, 46 eating disorder patients completed the same questionnaires at the end of therapy...
September 2015: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/25834398/in-vivo-antitumor-and-antimetastatic-effects-of-flavokawain-b-in-4t1-breast-cancer-cell-challenged-mice
#11
Nadiah Abu, Nurul Elyani Mohamed, Swee Keong Yeap, Kian Lam Lim, M Nadeem Akhtar, Aimi Jamil Zulfadli, Beh Boon Kee, Mohd Puad Abdullah, Abdul Rahman Omar, Noorjahan Banu Alitheen
Flavokawain B (FKB) is a naturally occurring chalcone that can be isolated through the root extracts of the kava-kava plant (Piper methysticum). It can also be synthesized chemically to increase the yield. This compound is a promising candidate as a biological agent, as it is reported to be involved in a wide range of biological activities. Furthermore, FKB was reported to have antitumorigenic effects in several cancer cell lines in vitro. However, the in vivo antitumor effects of FKB have not been reported on yet...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/25828372/regular-drug-eluting-stent-vs-dedicated-coronary-bifurcation-bioss-expert-stent-multicenter-open-label-randomized-controlled-polbos-i-trial
#12
RANDOMIZED CONTROLLED TRIAL
Robert J Gil, Jacek Bil, Vladimír Džavík, Dobrin Vassilev, Adam Kern, Radoslaw Formuszewicz, Małgorzata Zalewska-Adamiec, Sławomir Dobrzycki
BACKGROUND: Results of regular drug-eluting stents (rDESs) in bifurcation treatment are not optimal. The aim of the Polish Bifurcation Optimal Stenting I (POLBOS I) trial was to compare bifurcation treatment with any rDES vs the dedicated bifurcation paclitaxel-eluting stent BiOSS Expert (Balton, Poland). The second aim was to study the effect of final kissing balloon (FKB) inflation on clinical outcomes. METHODS: Between October 2010 and January 2013 patients with stable coronary artery disease or non-ST-elevation acute coronary syndrome were assigned 1:1 to 1 of 2 treatment strategies: BiOSS Expert stent or rDES implantation...
May 2015: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/25758264/effect-of-final-kissing-balloon-dilatation-after-one-stent-technique-at-left-main-bifurcation-a-single-center-data
#13
Zhan Gao, Bo Xu, Yue-Jin Yang, Shu-Bin Qiao, Yong-Jian Wu, Tao Chen, Liang Xu, Jin-Qing Yuan, Jue Chen, Xue-Wen Qin, Min Yao, Hai-Bo Liu, Shi-Jie You, Ye-Lin Zhao, Hong-Bing Yan, Ji-Lin Chen, Run-Lin Gao
BACKGROUND: Whether final kissing balloon (FKB) dilatation after one-stent implantation at left-main (LM) bifurcation site remains unclear. Therefore, this large sample and long-term follow-up study comparatively assessed the impact of FKB in patients with unprotected LM disease treated with one-stent strategy. METHODS: Total 1528 consecutive patients underwent LM percutaneous coronary intervention in one center from January 2004 to December 2010 were enrolled; among them, 790 patients treated with one drug-eluting stent crossover LM to left anterior descending (LAD) with FKB (n = 230) or no FKB (n = 560) were comparatively analyzed...
March 20, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/25185080/flavokawains-a-and-b-in-kava-not-dihydromethysticin-potentiate-acetaminophen-induced-hepatotoxicity-in-c57bl-6-mice
#14
Sreekanth C Narayanapillai, Pablo Leitzman, M Gerard O'Sullivan, Chengguo Xing
Anxiolytic kava products have been associated with rare but severe hepatotoxicity in humans. This adverse potential has never been captured in animal models, and the responsible compound(s) remains to be determined. The lack of such knowledge greatly hinders the preparation of a safer kava product and limits its beneficial applications. In this study we evaluated the toxicity of kava as a single entity or in combination with acetaminophen (APAP) in C57BL/6 mice. Kava alone revealed no adverse effects for long-term usage even at a dose of 500 mg/kg bodyweight...
October 20, 2014: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/25123348/neurobiological-correlates-of-physical-self-concept-and-self-identification-with-avatars-in-addicted-players-of-massively-multiplayer-online-role-playing-games-mmorpgs
#15
Tagrid Leménager, Julia Dieter, Holger Hill, Anne Koopmann, Iris Reinhard, Madlen Sell, Falk Kiefer, Sabine Vollstädt-Klein, Karl Mann
AIMS: MMORPG addiction has been associated with self-concept impairments and increased identification with the own avatar. Yet, the underlying neurobiological mechanisms of self-identification with avatars, especially reflected in the left angular gyrus (AG), have only been assessed in regular gamers. Therefore, the study aims to examine neurobiological processes in addicted MMORPG players while evaluating their own and their personal avatar's body image (physical self-concept). METHODS: Sixteen addicted and seventeen non-addicted gamers underwent functional Magnetic Resonance Imaging (fMRI) while viewing images of themselves, their own avatar and unfamiliar persons...
December 2014: Addictive Behaviors
https://www.readbyqxmd.com/read/24991578/the-effect-of-tlr9-agonist-cpg-oligodeoxynucleotides-on-the-intestinal-immune-response-of-cobia-rachycentron-canadum
#16
Omkar Byadgi, Dinda Puteri, Jai-Wei Lee, Tsung-Chou Chang, Yan-Horn Lee, Chun-Yen Chu, Ta-Chih Cheng
Cytosine-guanine oligodeoxynucleotide (CpG ODN) motifs of bacterial DNA are recognized through toll-like receptor 9 (TLR9) and are potent activators of innate immunity. However, the interaction between TLR9 and CpG ODN in aquatic species has not been well characterized. Hence, cobia TLR9 isoform B (RCTLR9B) was cloned and its expression and induction in intestine were investigated. RCTLR9B cDNA consists of 3113bp encoding 1009 amino acids containing three regions, leucine rich repeats, transmembrane domain, and toll/interleukin-1 receptor (TIR) domain...
2014: Journal of Immunology Research
https://www.readbyqxmd.com/read/24923438/specific-behaviour-mood-and-personality-traits-may-contribute-to-obesity-in-patients-with-craniopharyngioma
#17
J Roemmler-Zehrer, V Geigenberger, S Störmann, M Ising, H Pfister, C Sievers, G K Stalla, J Schopohl
INTRODUCTION: Patients with craniopharyngioma (CP) often suffer from obesity, but the underlying causes are still not fully understood. We compared CP to patients with nonfunctioning pituitary adenoma (NFPA) and to a control group (CG) using standardized questionnaires to investigate whether behavioural, mood or personality traits contribute to obesity. METHODS: We compared 31 patients with CP (42% male, 53 ± 15·1 years) to 26 patients with NFPA (71% male, 63·2 ± 10·3 years) and to age- and gender-matched local CG (ratio 2:1)...
January 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/24722377/chalcones-suppress-fatty-acid-induced-lipid-accumulation-through-a-lkb1-ampk-signaling-pathway-in-hepg2-cells
#18
Tianshun Zhang, Norio Yamamoto, Hitoshi Ashida
Excessive lipid accumulation in the liver has been proposed to cause hyperlipidemia, diabetes and fatty liver disease. 4-Hydroxyderricin (4HD), xanthoangelol (XAG), cardamonin (CAR) and flavokawain B (FKB) are chalcones that have exhibited various biological effects against obesity, inflammation, and diabetes; however, little is known about the inhibitory effects of these chalcones on fatty liver disease. In the present study, we investigated the ability of 4HD, XAG, CAR, and FKB to reduce lipid accumulation in hepatocytes...
June 2014: Food & Function
https://www.readbyqxmd.com/read/24423570/detection-of-flavokavins-a-b-c-in-cultivars-of-kava-piper-methysticum-using-high-performance-thin-layer-chromatography-hptlc
#19
V Lebot, T K T Do, L Legendre
Kava (Piper methysticum) is used to prepare the traditional beverage of the Pacific islands. In Europe, kava has been suspected to cause hepatoxicity with flavokavin B (FKB) considered as a possible factor. The present study describes an HPTLC protocol for rapid screening of samples. The objectives are: to detect the presence of flavokavins in extracts and to compare the FKB levels in different cultivars. Overall, 172 samples originating from four cultivars groups (noble, medicinal, two-days and wichmannii), were analysed...
May 15, 2014: Food Chemistry
https://www.readbyqxmd.com/read/24332424/the-absorb-bioresorbable-vascular-scaffold-in-coronary-bifurcations-insights-from-bench-testing
#20
Vladimír Džavík, Antonio Colombo
OBJECTIVES: This study sought to evaluate the feasibility of performing contemporary bifurcation techniques with the Absorb everolimus-eluting bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, California) (BVS). BACKGROUND: The feasibility of using the BVS in bifurcation lesions is unknown. METHODS: We performed bifurcation stenting procedures including main-vessel stenting with ballooning of the side branch through the BVS struts, T-stenting and crush and culotte procedures, in a synthetic arterial model...
January 2014: JACC. Cardiovascular Interventions
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