keyword
MENU ▼
Read by QxMD icon Read
search

Osteoprotegerin

keyword
https://www.readbyqxmd.com/read/29145460/trail-attenuates-rankl-mediated-osteoblastic-signalling-in-vascular-cell-mono-culture-and-co-culture-models
#1
Emma Harper, Keith D Rochfort, Hannah Forde, Colin Davenport, Diarmuid Smith, Philip M Cummins
BACKGROUND AND OBJECTIVES: Vascular calcification (VC) is a major risk factor for elevated cardiovascular morbidity/mortality. Underlying this process is osteoblastic signalling within the vessel wall involving complex and interlinked roles for receptor-activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG), and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). RANKL promotes vascular cell osteoblastic differentiation, whilst OPG acts as a neutralizing decoy receptor for RANKL (and TRAIL)...
2017: PloS One
https://www.readbyqxmd.com/read/29142489/correlation-between-osteoprotegerin-serum-level-and-coronary-calcification-using-coronary-artery-calcium-score-in-patient-with-moderate-severe-cardiovascular-risk-factor
#2
J Nugroho, Widorini Widorini
Coronary artery calcification is a part of atherosclerosis process associated with coronary heart disease. Recently, coronary artery calcification assessment using computed tomography (CT) is still the best noninvasive imaging with high sensitivity and specificity. Osteoprotegerin (OPG) is one of vascular calcification marker that through its role to bind receptor activator of nuclear factor-κβ ligand and inhibit osteoclastogenesis is suspected of playing a role for coronary calcification in atherosclerosis process...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29137353/mesenchymal-stem-cells-inhibit-rank-rankl-interactions-between-osteoclasts-and-th17-cells-via-osteoprotegerin-activity
#3
Kyung-Ah Cho, Minhwa Park, Yu-Hee Kim, Kyung-Ha Ryu, So-Youn Woo
Th17 cells play a critical role in several autoimmune diseases, including psoriasis and psoriatic arthritis (PsA). Psoriasis is a chronic inflammatory skin disease associated with systemic inflammation and comorbidities, such as PsA. PsA develops in nearly 70% of patients with psoriasis, and osteoclasts associated bone erosion is a hallmark of the disease. Thus far, the effect of Th17 cells on osteoclastogenesis via direct cell-to-cell interactions is less understood. In this study, we observed that Th17 cells directly promote osteoclast differentiation and maturation via expression of receptor activator of nuclear factor-κ β ligand (RANKL) in vitro...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29129760/the-key-role-of-proinflammatory-cytokines-matrix-proteins-rankl-opg-and-wnt-%C3%AE-catenin-in-bone-healing-of-hip-arthroplasty-patients
#4
Jean Cassuto, Agnetha Folestad, Jan Göthlin, Henrik Malchau, Johan Kärrholm
INTRODUCTION: We still lack understanding of why some implants fail while most remain stable after decades of use. Proinflammatory cytokines, matrix proteins and bone regulating cytokines of the RANKL/OPG (receptor activator of nuclear factor kappa B ligand/osteoprotegerin) and Wnt/β-catenin pathways are mandatory for normal bone repair but their spatial and temporal role in the healing of primary total hip arthroplasties (THA) has not been previously shown. MATERIALS AND METHODS: Twenty-four osteoarthritis patients with one-sided well-fixed primary THA were prospectively monitored during 18years (18Y) with repeated blood samples, clinical variables and radiographs...
November 9, 2017: Bone
https://www.readbyqxmd.com/read/29126229/osteoblast-amp-activated-protein-kinase-regulates-postnatal-skeletal-development-in-male-mice
#5
Ippei Kanazawa, Ayumu Takeno, Ken-Ichiro Tanaka, Masakazu Notsu, Toshitsugu Sugimoto
Studies have shown that AMP-activated protein kinase (AMPK), a crucial regulator of energy homeostasis, plays important roles in osteoblast differentiation and mineralization. However, little is known about in vivo roles of osteoblastic AMPK in bone development. Thus, to investigate in vivo roles of osteoblast AMPK, we conditionally inactivated Ampk in osterix (Osx)-expressing cells by crossing Osx-Cre mice with floxed AMPKα1 to generate mice lacking AMPKα1 in osteoblasts (Ampk-/- mice). Compared with wild-type and Ampk+/- mice, Ampk-/- mice displayed retardation of postnatal bone development, although bone deformity was not observed at birth...
November 3, 2017: Endocrinology
https://www.readbyqxmd.com/read/29125911/5-lipoxygenase-knockout-aggravated-apical-periodontitis-in-a-murine-model
#6
Y Wu, H Sun, B Yang, X Liu, J Wang
5-Lipoxygenase (5-LO) plays a vital role in the host innate immune response, including bacteria-induced inflammation. Apical periodontitis (AP) is due to immune disorders caused by imbalances between bacterial invasion and subsequent host defense response. In this work, we investigated the role of 5-lipoxygenase in AP by using 5- lo knockout mice (5- lo-/- mice). Results showed that 5- lo-/- mice had greater periapical bone loss and more osteoclasts positive for tartrate-resistant acid phosphatase staining than did wild-type mice, as determined by micro-computed tomography and histologic staining...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29124083/osteoprotegerin-autoantibodies-do-not-predict-low-bone-mineral-density-in-middle-aged-women
#7
Fariba Vaziri-Sani, Charlotte Brundin, Daniel Agardh
Purpose: Autoantibodies against osteoprotegerin (OPG) have been associated with osteoporosis. The aim was to develop an immunoassay for OPG autoantibodies and test their diagnostic usefulness of identifying women general population with low bone mineral density. Methods: Included were 698 women at mean age 55.1 years (range 50.4-60.6) randomly selected from the general population. Measurement of wrist bone mineral density (g/cm(2)) was performed of the non-dominant wrist by dual-energy X-ray absorptiometry (DXA)...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29122540/bone-abnormalities-in-young-male-rats-with-iron-intervention-and-possible-mechanisms
#8
Yanqin Li, Bin Bai, Yaohui Zhang
Studies suggest iron overload may cause bone lesion. The mechanisms are not well understood at present. Therefore, this study was designed to observe the effect of iron overload on bone metabolism in young male rats and explore its possible mechanism. Eighteen SD rats were randomly assigned to iron-loading and control groups. Fe-dextran (250 mg/kg of body weight) was injected intraperitoneally into the rats from iron-loading group, every other day for 5 weeks. The bone mineral density (BMD) of femur, length and diameter of tibia, and histological microstructure of femur and vertebra was determined...
November 6, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29121799/pueraria-lobate-inhibits-rankl-mediated-osteoclastogenesis-via-downregulation-of-creb-pgc1%C3%AE-c-fos-nfatc1-signaling
#9
Keun Ha Park, Dong Ryun Gu, Su Hyun Jin, Chi-Su Yoon, Wonmin Ko, Youn Chul Kim, Seoung Hoon Lee
Puerariae radix, the dried root of Pueraria lobate Ohwi, is known to prevent bone loss in ovariectomized mice; however, the precise molecular mechanisms are not understood. In this study, we investigated the effects and underlying mechanisms of action of Puerariae radix extract (PRE) on receptor activator of NF-[Formula: see text]B ligand (RANKL)-induced osteoclastogenesis. PRE dose-dependently inhibited osteoclast differentiation and formation, decreased the bone-resorbing activity of osteoclasts, and downregulated the expression of osteoclast differentiation marker genes...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29120587/matrix-metalloproteinase-2-and-osteoprotegrin-as-new-markers-of-increased-atherosclerotic-risk-in-egyptian-patients-with-chronic-kidney-disease
#10
Amany M Elsaeed, Amal H Ibrahiem, Asmaa A Ali
The prevalence of chronic kidney disease (CKD) is rising continuously. Cardiovascular disease (CVD) is among the leading causes of death and premature mortality of patients with CKD. It has been suggested that the assessment of CKD-associated CVD risk factors together with conventional risk factors should be performed in order to improve the prediction of coronary heart disease risk. The reduction of these factors seems to be effective in lowering cardiovascular (CV) morbidity and mortality in patients with CKD...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29116059/genetic-predictors-associated-with-diabetic-retinopathy-in-diabetic-foot-patients-a-preliminary-study
#11
Beata Mrozikiewicz-Rakowska, Magdalena Łukawska, Piotr Nehring, Konrad Szymański, Agnieszka Sobczyk-Kopcioł, Monika Krzyżewska, Paweł Maroszek, Rafał Płoski, Leszek Czupryniak
INTRODUCTION    Early detection of diabetic retinopathy (DR) is key for preventing irreversible blindness. Recent research has identified some of the genetic factors involved in the pathology of DR, although their precise underlying mechanisms remain unclear. OBJECTIVES    This pilot study aimed to determine genetic predictors of DR among patients with type 2 diabetes mellitus (T2DM) and diabetic foot (DF) based on pathogenetic pathways. PATIENTS AND METHODS    The study was conducted on 114 patients with T2DM and DF (64 with DR, 50 without DR) treated in the Medical University of Warsaw...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29115612/isopsoralen-regulates-ppar%C3%A2-%C3%AE-wnt-to-inhibit-oxidative-stress-in-osteoporosis
#12
Jian Wang, Gang Wang, Li Gong, Guanwen Sun, Bin Shi, Huhe Bao, Yan Duan
The present study aimed to examine the effects of isopsoralen against postmenopausal osteoporosis in an ovariectomized rat model. The ovariectomized rats were treated with three days 10 mg/kg isopsoralen or with three days 20 mg/kg isopsoralen. Alkaline phosphatase, the oxidative stress indicators and caspase‑3/9 were measured using ELISA assay kits. Reverse transcription‑quantitative polymerase chain reaction was used to measure collagen type I (Col I), osteocalcin and osteoprotegerin mRNA levels. Wnt, β‑catenin and peroxisome proliferators‑activated receptor γ (PPAR‑γ) were analyzed using western blot analysis...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115286/genetic-predictors-associated-with-diabetic-retinopathy-in-diabetic-foot-patients
#13
Beata Mrozikiewicz-Rakowska, Magdalena Łukawska, Piotr Nehring, Konrad Szymański, Agnieszka Sobczyk-Kopcioł, Monika Krzyżewska, Paweł Maroszek, Rafał Płoski, Leszek Czupryniak
INTRODUCTION: Early detection of diabetic retinopathy (DR) is key for preventing irreversible blindness. Recent research has identified some of the genetic factors involved in the pathology of DR, although their precise underlying mechanisms remain unclear. OBJECTIVES: This pilot study aimed to determine genetic predictors of DR among patients with type 2 diabetes mellitus (T2DM) and diabetic foot (DF) based on pathogenetic pathways. PATIENTS AND METHODS: The study was conducted on 114 patients with T2DM and DF (64 with DR, 50 without DR) treated in the Medical University of Warsaw...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29109092/screening-for-multiple-autoantibodies-in-plasma-of-patients-with-breast-cancer
#14
REVIEW
Lauren Bassaro, Stephen J Russell, Elzbieta Pastwa, Stella A Somiari, Richard I Somiari
BACKGROUND/AIM: Autoantibodies have potential as circulating biomarkers for early cancer detection. This study aimed to screen for known autoantibodies in human plasma using an Autoantibody Profiling System (APS) and quantify the levels in plasma of donors with/without breast cancer. MATERIALS AND METHODS: Plasma from nine female donors diagnosed with breast cancer (test group) and nine matched donors with no personal history of cancer (reference group) were screened with an APS containing probes for 30 autoantibodies...
November 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29103161/multiple-vertebral-osteonecroses-k%C3%A3-mmell-s-disease-after-10%C3%A2-years-on-denosumab-is-osteocyte-apoptosis-to-blame
#15
Yves Maugars, Géraldine Bart, Pascale Guillot, Marguerite Chemel-Mary, Joëlle Glémarec, Mélanie Gahier-Penhoat, Benoit Le Goff, Christelle Darrieutort-Laffite
We report here a case of multiple vertebral osteonecroses with intrasomatic gaseous dissection (Kümmell's disease) occurring 1 year after the end of a 10-year course of denosumab treatment for osteoporosis without fractures. Histomorphometry and bone remodeling markers revealed major bone resorption and the persistence of an inhibition of bone formation. The presence of multiple empty lacunae in the bone provided evidence for high levels of osteocyte apoptosis. Osteocytes direct bone resorption (via the RANK/RANK-L/osteoprotegerin system) and formation (Wnt system, with SOST and DKK1) pathways...
November 4, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29100354/mechanism-of-genistein-regulating-the-differentiation-of-vascular-smooth-muscle-cells-into-osteoblasts-via-the-opg-rankl-pathway
#16
Cheng Shen, Ye Yuan, Fuping Li, Yijie Hu, Yi Song, Shulin Zhao, Qianjin Zhong
Objective: The present study aimed to investigate the mechanism of genistein, a tyrosine kinase inhibitor, regulating the differentiation of vascular smooth muscle cells (VSMCs) into osteoblasts via the OPG/RANKL (Osteoprotegerin/Receptor Activator of Nuclear Factor-κB Ligand) pathway. Methods: The mouse VSMCs were isolated, purified and cultured. We constructed the LV5-Tnfrsf11b overexpression lentiviral vector and LV3-OPG-309 interference lentiviral vector. The OPG overexpression was induced and the growth of VSMCs infected with the lentiviral vector was observed...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099236/effect-of-incisal-loading-during-orthodontic-treatment-in-adults-a-randomized-control-trial
#17
Pornputthi Puttaravuttiporn, Mutita Wongsuwanlert, Chairat Charoemratrote, Steven J Lindauer, Chidchanok Leethanakul
OBJECTIVE: To measure the changes in tooth mobility, alveolar bone, and receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) during orthodontic treatment to regain incisal function in the presence and absence of biting exercises. MATERIALS AND METHODS: Thirty-six females (42.3 ± 6.5 years old) with periodontally compromised upper incisors received orthodontic treatment to obtain ideal incisor relationships...
November 3, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/29098370/biomarkers-of-hand-osteoarthritis
#18
REVIEW
Tereza Lennerová, Karel Pavelka, Ladislav Šenolt
Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose the disease earlier, to distinguish patients with erosive and non-erosive forms, to assess disease severity or to predict its future progression. The objective of this review was to summarize the role of potential biomarkers of hand OA...
November 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29098241/-hypoxia-regulates-the-expression-of-opg-rankl-mrna-in-rat-bone-marrow-mesenchymal-stem-cells
#19
Xin-Lian Shi, Bi-Bo Hu, Man-Man Ren, Wen-Bin Yu, Hui Deng
PURPOSE: To investigate the effects of hypoxia on the expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) mRNA in rat bone marrow mesenchymal stem cells (rBMSCs). METHODS: rBMSCs were isolated and cultured by whole bone marrow cell adherent method, and an optimal hypoxic preconditioning model was established with CoCl2 (cobalt chloride). rBMSCs were incubated in cell culture mediums with different concentrations of CoCl2 (final concentrations of CoCl2 were 0, 50, 100, 200, 400 μmol/L) and incubated for different times...
June 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29094257/the-effects-of-exendin-4-on-bone-marrow-derived-mesenchymal-cells
#20
Paola Luciani, Benedetta Fibbi, Benedetta Mazzanti, Cristiana Deledda, Lara Ballerini, Alessandra Aldinucci, Susanna Benvenuti, Riccardo Saccardi, Alessandro Peri
PURPOSE: GLP-1 receptor agonists are antidiabetic drugs currently used in the therapy of type 2 diabetes. Despite several in vitro and in vivo animal studies suggesting a beneficial effect of GLP-1 analogues on bone, in humans their skeletal effects are not clear and clinical studies report conflicting results. METHODS: We differentiated human mesenchymal stromal cells (hMSC) toward the adipogenic and the osteoblastic lineages, analysing the effect of Exendin-4 (EXE) before, during and after specific differentiations...
November 1, 2017: Endocrine
keyword
keyword
72793
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"