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Osteoprotegerin

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https://www.readbyqxmd.com/read/29791169/-epicardial-fat-and-osteoprotegerin-does-a-mutual-relation-exist-pilot-study
#1
Markéta Sovová, Eliška Sovová, Jana Zapletalová, Markéta Kaletová, David Stejskal, Milan Sova, Michal Konečný, Vlastimil Procházka, Drahomíra Vrzalová, Lea Zarivnijová
INTRODUCTION: Epicardial fat (EPI) plays important role in development of metabolic and cardiovascular diseases. According to population studies EPI represents independent risk factor of cardiovascular diseases (CVD) and also for neoplasms. Osteoprotegerin (OPG) is a glycoprotein which have role in regulation of immune and cardiovascular systems. High serum levels of OPG are connected with high cardiovascular risk. The aim of our study was to evaluate possible correlation between EPI and OPG level in asymptomatic relatives of patients with CVD...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29785076/role-of-osteoprotegerin-receptor-activator-of-nuclear-factor-kappa-b-receptor-activator-of-nuclear-factor-kappa-b-ligand-axis-in-nonalcoholic-fatty-liver-disease
#2
REVIEW
Lucia Pacifico, Gian Marco Andreoli, Miriam D'Avanzo, Delia De Mitri, Pasquale Pierimarchi
Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease (NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children. Patients with fatty liver display features of metabolic syndrome (MetS), like insulin resistance (IR), glucose intolerance, hypertension and dyslipidemia. Recently, epidemiological studies have linked obesity, MetS, and NAFLD to decreased bone mineral density and osteoporosis, highlighting an intricate interplay among bone, adipose tissue, and liver...
May 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29770800/current-and-future-circulating-biomarkers-for-cardiac-amyloidosis
#3
REVIEW
Marco Luciani, Luca Troncone, Federica Del Monte
Cardiac amyloidosis (CA) comprises a heterogeneous group of medical conditions affecting the myocardium. It presents with proteinaceous infiltration with variable degrees of severity, prevalence and evolution. Despite this heterogeneity, erroneous protein folding is the common pathophysiologic process, yielding the formation of a single misfolded protein (monomer) that progressively evolves and ultimately forms amyloid fibers. Additionally, by seeding out from the organs of origin, intermediates called oligomers metastasize and restart the process...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29749583/il-35-a-new-immunomodulator-in-autoimmune-rheumatic-diseases
#4
REVIEW
Lazaros I Sakkas, Athanasios Mavropoulos, Carlo Perricone, Dimitrios P Bogdanos
IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and their receptors also share subunits. Whereas IL-12 and IL-23 are clearly proinflammatory cytokines, the role of IL-35 is less clear. In mice, IL-35 appears to be anti-inflammatory and to protect from autoimmune inflammatory diseases. IL-35 induces the expansion of a subset of regulatory T cells (Tregs) and Bregs and mediates their suppressive function and inhibits Th17 cells...
May 11, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29749489/effects-of-osteoprotegerin-tnfrsf11b-in-two-models-of-abdominal-aortic-aneurysms
#5
Emina Vorkapic, Anne Kunath, Dick Wågsäter
Osteoprotegerin (OPG), additionally termed tumor necrosis factor receptor superfamily member 11B, is produced by vascular smooth muscle cells (VSMCs) and endothelial cells in the vasculature, and its release may be modulated by pro‑inflammatory cytokines, including interleukin‑1β and tumor necrosis factor‑α. The present study investigated the effects of treatment with low‑dose human recombinant OPG on abdominal aortic aneurysm (AAA) development in mice. Mice were treated with 1 µg human recombinant OPG four times (or vehicle) for 2 weeks prior to inducing AAA...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749449/dishevelled%C3%A2-2-modulates-osteogenic-differentiation-of-human-synovial-fibroblasts-in-osteoarthritis
#6
Lihua Zhang, Luan Luan, Yingying Ma
Dishevelled (Dvl)‑2 represents one of the cytoplasmic proteins, which serves as a pivotal hub in signaling intermediates through a number of different signaling pathways associated with the Wnt family. The aim of the present study was to investigate the roles and mechanisms of Dvl‑2 on synovial fibroblasts (SFBs) in osteoarthritis (OA). A Cell Counting kit‑8 (CCK‑8) assay was used to determine cell viability. An alkaline phosphatase (ALP) test kit was used to measure the activity of ALP. Western blot and reverse transcription‑quantitative polymerase chain reaction analysis were used to evaluate the protein and mRNA expression, respectively...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29742566/comparative-evaluation-of-cell-viability-immediately-after-osteotomy-for-implants-with-drills-and-piezosurgery-immunohistochemistry-analysis
#7
Cassiano Costa Silva Pereira, Fábio Roberto de Souza Batista, Ricardo Garcia Mureb Jacob, Lamis Meorin Nogueira, Abrahão Cavalcante Gomes de Souza Carvalho, Walter Cristiano Gealh, Idelmo Rangel Garcia-Júnior, Roberta Okamoto
OBJECTIVE: To evaluate the effect of reusing drills and piezosurgery tips during implant osteotomy on immediate bone cell viability through immunohistochemical analysis. MATERIALS AND METHODS: Six male rabbits were divided into 2 groups and then divided into 5 subgroups-correspond to drills and tips used 10, 20, 30, 40, and 50 times, respectively. All animals received 10 osteotomies in each tibia, by use of the classic drilling procedure in one group (G1) and the piezosurgery device in the other group (G2)...
May 8, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29741767/down-regulation-of-intracellular-anti-apoptotic-proteins-particularly-c-flip-by-therapeutic-agents-the-novel-view-to-overcome-resistance-to-trail
#8
REVIEW
Ali Hassanzadeh, Majid Farshdousti Hagh, Mohammad Reza Alivand, Ali Akbar Movassaghpour Akbari, Karim Shams Asenjan, Raedeh Saraei, Saeed Solali
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) is a member of the tumor necrosis factor (TNF) superfamily that induces apoptosis in different types of cancer cells via activation of caspase cascade. TRAIL interacts with its cognate receptors that placed on cancer cells surface, including TRAIL-R1 (death receptor 4, DR4), TRAIL-R2 (death receptor 5, DR5), TRAIL-R3 (decoy receptor 1, DcR1), TRAIL-R4 (decoy receptor 2, DcR2), and osteoprotegerin (OPG). Despite high apoptosis-inducing ability of TRAIL, various cancerous cells gain resistance to TRAIL gradually, and consequently TRAIL potential for apoptosis stimulation in these cells diminishes intensely...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29736604/selective-inhibition-of-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-rankl-in-hematopoietic-cells-improves-outcome-after-experimental-myocardial-infarction
#9
Svetlana Slavic, Olena Andrukhova, Kristopher Ford, Stephan Handschuh, Nejla Latic, Ursula Reichart, Soleman Sasgary, Claudia Bergow, Lorenz C Hofbauer, Paul J Kostenuik, Reinhold G Erben
The RANK (receptor activator of nuclear factor κB)/RANKL (RANK ligand)/OPG (osteoprotegerin) axis is activated after myocardial infarction (MI), but its pathophysiological role is not well understood. Here, we investigated how global and cell compartment-selective inhibition of RANKL affects cardiac function and remodeling after MI in mice. Global RANKL inhibition was achieved by treatment of human RANKL knock-in (huRANKL-KI) mice with the monoclonal antibody AMG161. huRANKL-KI mice express a chimeric RANKL protein wherein part of the RANKL molecule is humanized...
May 8, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29734465/postnatal-skeletal-deletion-of-dickkopf-1-increases-bone-formation-and-bone-volume-in-male-and-female-mice-despite-increased-sclerostin-expression
#10
Juliane Colditz, Sylvia Thiele, Ulrike Baschant, Christof Niehrs, Lynda F Bonewald, Lorenz C Hofbauer, Martina Rauner
The Wnt antagonist Dickkopf-1 (Dkk1) is a negative regulator of osteoblast function and bone mass. However, due to the lack of appropriate models, many aspects of its role in the regulation of postnatal bone turnover and its cellular source have remained unknown. In this study, we deleted Dkk1 postnatally and in different cell types using various Cre-drivers (Rosa26-ERT2-Cre, Osx-cre,Dmp1-Cre) and assessed to which extent cells of the osteoblastic lineage contribute to the effects of Dkk1 on bone turnover and homeostasis...
May 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29729471/meningioma-and-bone-hyperostosis-expression-of-bone-stimulating-factors-and-review-of-the-literature
#11
Andrea Di Cristofori, Massimiliano Del Bene, Marco Locatelli, Francesca Boggio, Giulia Ercoli, Stefano Ferrero, Alessandro Del Gobbo
OBJECTIVE: Several hypothesis have been proposed in order to understand the mechanisms underlying the meningioma related hyperostosis. Objective of our study was to investigate the role of osteoprotegerin(OPG), insulin-like growth factor-1(IGF-1), endothelin-1(ET-1), Bone Morphogenetic Protein(BMP-2 and -4). METHODS: A total of 149 patients (39 males and 110 females with a mean age of 62 years) that received surgery were included. Depending on the relationship with the bone, meningiomas were classified in hyperostotic, osteolytic, infiltrative and without relation with the bone...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29729375/clinical-predictive-biomarkers-for-normoalbuminuric-diabetic-kidney-disease
#12
Tomohito Gohda, Yuji Nishizaki, Maki Murakoshi, Shuko Nojiri, Naotake Yanagisawa, Terumi Shibata, Mami Yamashita, Kanako Tanaka, Yoshinori Yamashita, Yusuke Suzuki, Nozomu Kamei
AIMS: A portion of patients with diabetes mellitus follow the progression of a non-albuminuria-based pathway; i.e., normoalbuminuric diabetic kidney disease (NA-DKD). However, the risk factors which determine NA-DKD are not yet fully understood. This cross-sectional study was therefore aimed to investigate the association between various biomarker levels and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus and normoalbuminuria (T2D-NA). METHODS: We measured cardiovascular disease (CVD) [serum osteoprotegerin (OPG), plasma brain natriuretic peptide (BNP), cardio-ankle vascular index (CAVI)], tubular damage [urinary L-type fatty acid binding protein (L-FABP)], and inflammatory [serum tumornecrosis factor (TNF) α and its receptors (TNFRs)] biomarkers in 314 patients with T2D-NA...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29725510/role-of-serum-osteoprotegerin-as-a-diagnostic-indicator-of-primary-osteoporosis-in-perimenopausal-and-postmenopausal-women-an-indian-perspective
#13
A Pandey, Y A Khan, S S Kushwaha, F Mohammed, A Verma
Introduction: Osteoporosis (OP) is a major health problem in the older population. The aim of the study was to assess the role of serum osteoprotegerin (OPG) as a diagnostic indicator of primary osteoporosis in peri- and post-menopausal women in an Indian population. Materials and Methods: After ethical approval, 90 cases (45 cases and 45 controls) of peri- and post-menopausal females above 40 years of age presenting to our outpatient department were included in the study. It was a case controlled study conducted between July 2014 to July 2015...
March 2018: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29721726/association-between-serum-lipid-levels-osteoprotegerin-and-depressive-symptomatology-in-psychotic-disorders
#14
Sherif M Gohar, Ingrid Dieset, Nils Eiel Steen, Ragni H Mørch, Trude S Iversen, Vidar M Steen, Ole A Andreassen, Ingrid Melle
Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group, n = 344); bipolar I, II, NOS, and psychosis NOS (non-schizophrenia group, n = 308) were recruited consecutively from the Norwegian Thematically Organized Psychosis (TOP) Study...
May 2, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29719588/effects-of-repeated-sprints-training-on-fracture-risk-associated-mirna
#15
Veronica Sansoni, Silvia Perego, Gianluca Vernillo, Andrea Barbuti, Giampiero Merati, Antonio La Torre, Giuseppe Banfi, Giovanni Lombardi
Repeated-sprint training (RS, short-duration sprints at supramaximal intensities interspersed with brief recoveries) is a time-saving metabolically effective strategy whose effects on bone are unknown. Bone metabolism is a finely regulated process profoundly affected by exercise as assayable by studying specific systemic (e.g., hormones, cytokines) and bone-derived molecules (e.g., bone markers, miRNAs). Aim of this study was to determine the effect of a 8-week repeated-sprint on circulating levels of fracture risk-associated miRNA...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717766/bu%C3%A2-shen%C3%A2-ning%C3%A2-xin-decoction-suppresses-osteoclastogenesis-by-modulating-rankl-opg-imbalance-in-the-cd4-t-lymphocytes-of-ovariectomized-mice
#16
Jia-Li Zhang, Xue-Min Qiu, Na Zhang, Wei Tang, Hans-Jürgen Gober, Da-Jin Li, Ling Wang
Postmenopausal osteoporosis (PMO) has been recognized as an inflammatory condition. CD4+ T cells serve a key role in the interaction between bone metabolism and the immune system. Bu‑Shen‑Ning‑Xin decoction (BSNXD), a traditional Chinese medicine, has been ultilized as a remedy for PMO. In the present study, the aim was to investigate the immune modulatory effects of BSNXD on CD4+ T cells, receptor activation of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) imbalance, skeletal parameters and osteoclastogenesis...
April 26, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29710663/effect-of-zuoguiwan-on-osteoporosis-in-ovariectomized-rats-through-rankl-opg-pathway-mediated-by-%C3%AE-2ar
#17
Feixiang Liu, Feng Tan, Weiwei Tong, Qiaoling Fan, Sumin Ye, Shengfeng Lu, Zhanli Teng, Miaomiao Han, Mingyue Zhang, Yi Chai
ETHNOPHARMACOLOGICAL RELEVANCE: The deficiency of kidney Yin is the main pathogenesis of postmenopausal osteoporosis (PMOP) according to traditional Chinese medicine (TCM). Zuoguiwan (ZGW) is among the classical prescriptions in TCM and has been applied to various diseases that are due to deficiency of kidney Yin, including osteoporosis, fractures, menopausal syndromes. However, the underlying mechanism of ZGW in treating PMOP remains poorly understood. AIM OF THE STUDY: ZGW, a traditional Chinese prescription, has been used to nourish Yin and reinforce the kidney since ancient times...
April 25, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29705418/short-communication-serum-osteoprotegerin-concentrations-in-periparturient-dairy-cows
#18
Kaoru Hatate, Chiho Kawashima, Masaaki Hanada, Mitsunori Kayano, Norio Yamagishi
Dairy cows experience hypocalcemia at the onset of lactation; however, the contribution of bone metabolism to circulating Ca concentrations during the periparturient period is not well understood. Osteoprotegerin (OPG) protects against loss of skeletal mass by regulating osteoclastogenesis. We previously reported that the bone resorption increased around parturition in dairy cows from the perspective of bone markers in blood. The aim of this study was to explore osteoclastic bone resorption in periparturient dairy cows by measuring changes in serum OPG concentrations around calving...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29699580/genetic-deletion-of-muscle-rank-or-selective-inhibition-of-rankl-is-not-as-effective-as-full-length-opg-fc-in-mitigating-muscular-dystrophy
#19
Sébastien S Dufresne, Antoine Boulanger-Piette, Sabrina Bossé, Anteneh Argaw, Dounia Hamoudi, Laetitia Marcadet, Daniel Gamu, Val A Fajardo, Hideo Yagita, Josef M Penninger, A Russell Tupling, Jérôme Frenette
Although there is a strong association between osteoporosis and skeletal muscle atrophy/dysfunction, the functional relevance of a particular biological pathway that regulates synchronously bone and skeletal muscle physiopathology is still elusive. Receptor-activator of nuclear factor κB (RANK), its ligand RANKL and the soluble decoy receptor osteoprotegerin (OPG) are the key regulators of osteoclast differentiation and bone remodelling. We thus hypothesized that RANK/RANKL/OPG, which is a key pathway for bone regulation, is involved in Duchenne muscular dystrophy (DMD) physiopathology...
April 24, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29698972/icariin-restores-bone-structure-and-strength-in-a-rat-model-of-chronic-high-dose-alcohol-induced-osteopenia
#20
Jie-Zhou Wu, Peng-Cheng Liu, Run Liu, Ming Cai
BACKGROUND/AIMS: Chronic alcohol abuse is an important risk factor for osteopenia. However, few studies have focused on the efficacy and mechanism of action of icariin on alcohol-induced osteopenia. The aim of this study was to investigate the efficacy and underlying mechanism of action of icariin in the treatment of chronic high-dose alcohol-induced osteopenia in a rat model. METHODS: Thirty-six adult male Sprague-Dawley rats were randomly divided into four groups: sham, alcohol, and low-dose and high-dose icariin groups...
April 23, 2018: Cellular Physiology and Biochemistry
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