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https://www.readbyqxmd.com/read/28105682/guanine-can-direct-binding-specificity-of-ru-dppz-complexes-to-dna-through-steric-effects
#1
James Pearce Hall, Sarah Prava Gurung, Jessica Henle, Patrick Poidl, Johanna Andersson, Per Lincoln, Graeme Winter, Thomas Sorensen, David John Cardin, John Alan Brazier, Christine Janet Cardin
X-ray crystal structures of three Λ-[Ru(L)2dppz]2+ complexes (L=phen, bpy) bound to d((5BrC)GGC/GCCG) show the compounds intercalated at a 5´-CG-3´ step. The compounds bind through canted intercalation, with the binding angle determined by the guanine-NH2 group, in contrast to symmetrical intercalation previously observed at 5´-TA-3´ sites. This result suggests that canted intercalation is preferred at 5´-CG-3´ sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5´-CG-3´ step could give rise to a longer luminescence lifetime than canted intercalation...
January 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28099315/factors-associated-with-visual-outcome-after-macula-off-rhegmatogenous-retinal-detachment-surgery
#2
Dae Hyun Park, Kyung Seek Choi, Hae Jung Sun, Sung Jin Lee
PURPOSE: To evaluate preoperative factors influencing the visual outcome and postoperative factors associated with the changes in visual acuity, after reattachment surgery to treat macula-off rhegmatogenous retinal detachment. METHODS: A total of 180 eyes of 180 patients who underwent reattachment surgery to treat macula-off rhegmatogenous retinal detachment, and who were followed up for more than 12 months, were reviewed retrospectively. Preoperative and postoperative characteristics, including optical coherence tomography findings, were comprehensively analyzed using univariate and multivariate models to evaluate preoperative factors influencing best-corrected visual acuity 12 months after macula-off rhegmatogenous retinal detachment surgery and postoperative factors associated with changes in best-corrected visual acuity after surgery...
January 17, 2017: Retina
https://www.readbyqxmd.com/read/28099203/evaluation-of-gene-expression-patterns-in-micrografts-demonstrate-induction-of-catagen-like-processes-during-storage
#3
Walter Krugluger, Karl Stiefsohn, Karl Moser, Claudia Moser, Katarina Laciak
BACKGROUND: Alterations of gene expression patterns may contribute to the commonly observed transient reduction of hair shaft elongation in hair restoration surgery. OBJECTIVE: To elucidate the molecular causes, we evaluated changes in gene expression patterns in hair follicle micrografts during storage. MATERIALS AND METHODS: Micrografts with different amounts of adjacent connective tissue (regular, skinny, and chubby) were stored for different periods, and the expression of key genes was determined: dermal papilla (DP): FGF7, alkaline phosphatase (ALP), versican; outer root sheath: Krt15; inner root sheath: Krt 25; cuticula: Krt85; Henle layer: filaggrin; genes related to apoptosis and growth/differentiation: Caspase 3, Ovol1, and Foxo1...
January 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28095294/a-novel-slc12a1-gene-mutation-associated-with-hyperparathyroidism-hypercalcemia-nephrogenic-diabetes-insipidus-and-nephrocalcinosis-in-four-patients
#4
Sariya Wongsaengsak, Alaina P Vidmar, Ananta Addala, Elaine S Kamil, Paola Seqeira, Benjamin Fass, Pisit Pitukcheewanont
Solute Carrier Family 12 member 1 (SLC12A1) gene encodes the sodium-potassium-chloride co-transporter (NKCC2) at the apical membrane of the thick ascending loop of Henle (TAL). Bartter's syndrome (BS) type I is a rare, autosomal recessive, renal tubular disorder associated with mutation of the SLC12A1 gene. Presenting features include: hypokalemic metabolic alkalosis, hypercalciuria and nephrocalcinosis. The many allelic variants reported present with a spectrum of phenotypes, biochemical abnormalities and clinical severities...
January 14, 2017: Bone
https://www.readbyqxmd.com/read/28060396/vascular-features-of-full-thickness-macular-hole-by-oct-angiography
#5
Stanislao Rizzo, Alfonso Savastano, Daniela Bacherini, Maria Cristina Savastano
BACKGROUND AND OBJECTIVE: To compare the features of cystoid cavities associated with full-thickness macular hole (FTMH) imaged with optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Prospective, observational, cross-sectional study. Clinical practice and observation. Thirteen patients (13 eyes) with FTMH were evaluated before vitrectomy. All eyes underwent OCTA or en face OCT imaging. RESULTS: There was a statistically significant positive correlation between groups for the total cavity area in both inner nuclear layer (P < ...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28028216/mosaic-expression-of-claudins-in-thick-ascending-limbs-of-henle-results-in-spatial-separation-of-paracellular-na-and-mg2-transport
#6
Susanne Milatz, Nina Himmerkus, Vera Christine Wulfmeyer, Hoora Drewell, Kerim Mutig, Jianghui Hou, Tilman Breiderhoff, Dominik Müller, Michael Fromm, Markus Bleich, Dorothee Günzel
The thick ascending limb (TAL) of Henle's loop drives paracellular Na(+), Ca(2+), and Mg(2+) reabsorption via the tight junction (TJ). The TJ is composed of claudins that consist of four transmembrane segments, two extracellular segments (ECS1 and -2), and one intracellular loop. Claudins interact within the same (cis) and opposing (trans) plasma membranes. The claudins Cldn10b, -16, and -19 facilitate cation reabsorption in the TAL, and their absence leads to a severe disturbance of renal ion homeostasis. We combined electrophysiological measurements on microperfused mouse TAL segments with subsequent analysis of claudin expression by immunostaining and confocal microscopy...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27995452/an-optimal-approach-for-laparoscopic-d3-lymphadenectomy-plus-complete-mesocolic-excision-d3-cme-for-right-sided-colon-cancer
#7
Daxing Xie, Chaoran Yu, Chun Gao, Hasan Osaiweran, Junbo Hu, Jianping Gong
BACKGROUND: It is common knowledge that high ligation of blood vessels at the D3 level and complete mesocolic excision (CME) are two critical points of right hemicolectomy for right colon cancer (RCC). (1-5) To date, a safe strategy for completing these two procedures under laparoscopic surgery has not been extensively described. The authors provide a video to demonstrate laparoscopic right hemicolectomy (D3 + CME) with an optimal mesentery-defined approach. By identifying three "tri-junctions," this approach facilitates dissection of the entire mesocolon along the embryologic planes as far centrally as possible and enables the high tie of feeding vessels at bifurcation...
December 19, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27973339/a-new-genus-of-rhinebothriidean-cestodes-from-batoid-elasmobranchs-with-the-description-of-five-new-species-and-two-new-combinations
#8
Florian B Reyda, Claire J Healy, Andrew R Haslach, Timothy R Ruhnke, Tara L Aprill, Michael P Bergman, Andrew L Daigler, Elsie A Dedrick, Illari Delgado, Kathryn S Forti, Kaylee S Herzog, Rebecca S Russell, Danielle D Willsey
Survey work of batoid elasmobranchs in the eastern Atlantic and Indo-Pacific revealed multiple species of a new genus of cestode. Stillabothrium Healy et Reyda gen. n. (Rhinebothriidea: Escherbothriidae) is unique in its possession of an even number of non-medial longitudinal septa in the posterior portion of the bothridia, resulting in a series of loculi that are longer than wide (i.e. vertically oriented) and are arranged in columns. Five new species of Stillabothrium are described, S. ashleyae Willsey et Reyda sp...
November 10, 2016: Folia Parasitologica
https://www.readbyqxmd.com/read/27926554/intraoperative-archive-of-right-colonic-vascular-variability-aids-central-vascular-ligation-and-redefines-gastrocolic-trunk-of-henle-variants
#9
Jamal F Alsabilah, Syed A Razvi, Mahdi H Albandar, Nam K Kim
BACKGROUND: Vascular supply to the right colon has become an issue because of high variability and subsequent impact on minimally invasive surgery. Past cadaveric or radiologic anatomic assessments are noncomprehensive. OBJECTIVE: Intraoperative charting of right colonic arteriovenous anatomy was undertaken to determine the incidence and scope of vascular variations. DESIGN: Vascular anatomy variations were documented in snapshot images, captured during laparoscopic video recordings or through open surgical digital photography...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27924355/avp-dynamically-increases-paracellular-na-permeability-and-transcellular-nacl-transport-in-the-medullary-thick-ascending-limb-of-henle-s-loop
#10
REVIEW
Nina Himmerkus, Allein Plain, Rita D Marques, Svenja R Sonntag, Alexander Paliege, Jens Leipziger, Markus Bleich
The medullary thick ascending limb of Henle's loop (mTAL) is crucial for urine-concentrating ability of the kidney. It is water tight and able to dilute the luminal fluid by active transcellular NaCl transport, fueling the counter current mechanism by increasing interstitial osmolality. While chloride is exclusively transported transcellularly, approx. 50% of sodium transport occurs via the paracellular route, driven by the lumen-positive transepithelial potential. Antidiuretic hormone (AVP) is known to increase active NaCl transport to support collecting duct water reabsorption...
January 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27920129/chronic-inhibition-of-renal-outer-medullary-potassium-channel-not-only-prevented-but-also-reversed-development-of-hypertension-and-end-organ-damage-in-dahl-salt-sensitive-rats
#11
Xiaoyan Zhou, Michael J Forrest, Wanda Sharif-Rodriguez, Gail Forrest, Daphne Szeto, Olga Urosevic-Price, Yonghua Zhu, Andra S Stevenson, Yuchen Zhou, Sloan Stribling, Maya Dajee, Shawn P Walsh, Alexander Pasternak, Kathleen A Sullivan
The renal outer medullary potassium (ROMK) channel mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Evidence from the phenotype of humans and rodents with functional ROMK deficiency supports the contention that selective ROMK inhibitors (ROMKi) will represent a novel diuretic with potential of therapeutic benefit for hypertension. ROMKi have recently been synthesized by Merck & Co, Inc...
December 5, 2016: Hypertension
https://www.readbyqxmd.com/read/27906863/bartter-s-and-gitelman-s-syndrome
#12
Hannsjörg W Seyberth, Stefanie Weber, Martin Kömhoff
PURPOSE OF REVIEW: The clinical presentations of Bartter's syndrome and Gitelman's syndrome will be reviewed including two most recently described hypokalemic salt-losing tubulopathies. By taking the quite heterogeneous presentations and the apparently different pathophysiologies as the basis, the applicability of the physiologic classification has been tested. RECENT FINDINGS: According to the physiologic approach, salt-losing tubulopathies can be divided into two major groups (with completely different tubular defects): first, disorders of the thick ascending limb of Henle's loop (loop disorders); second, disorders of the distal convolute tubule (DCT disorders)...
November 30, 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27900834/transformation-of-free-and-dipeptide-bound-glycated-amino-acids-by-two-strains-of-saccharomyces-cerevisiae
#13
Michael Hellwig, Marie Börner, Falco Beer, Karl-Heinz van Pée, Thomas Henle
The yeast Saccharomyces cerevisiae transforms branched-chain and aromatic amino acids into higher alcohols in the Ehrlich pathway. During microbiological culturing and industrial fermentations, this yeast is confronted with amino acids modified by reducing sugars in the Maillard reaction (glycation). In order to gain some preliminary insight into the physiological "handling" of glycated amino acids by yeasts, individual Maillard reaction products (MRPs: fructosyllysine, carboxymethyllysine, pyrraline, formyline, maltosine, methylglyoxal-derived hydroimidazolone) were administered to two strains of S...
November 30, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27811793/parasitic-copepods-infesting-the-olfactory-sacs-of-skates-from-the-southwestern-atlantic-with-the-description-of-a-new-species-of-kroeyerina-wilson-1932
#14
Manuel M Irigoitia, Delfina M P Cantatore, Inés S Incorvaia, Juan T Timi
The olfactory sacs of 488 specimens belonging to 18 species of rajid and arhynchobatid skates from the Argentine Sea were sampled for parasites. No parasitic copepods were found in 11 host species, but siphonostomatoid specimens referable to Kroeyerina Wilson, 1932 (Kroyeriidae) and Brianella corniger Wilson, 1915 (Lernaeopodidae) were found on the spotback skate Atlantoraja castelnaui (Miranda Ribeiro, 1907), the smallnose fanskate Sympterygia bonapartii Müller & Henle, 1841, the bignose fanskate Sympterygia acuta Garman, 1877 and the zipper sand skate Psammobatis extenta (Garman, 1913) (Rajiformes: Arhynchobatidae)...
October 11, 2016: Zootaxa
https://www.readbyqxmd.com/read/27811779/redescription-of-the-rare-and-endangered-broadfin-shark-lamiopsis-temminckii-m%C3%A3-ller-henle-1839-carcharhiniformes-carcharhinidae-from-the-northeastern-arabian-sea
#15
K V Akhilesh, W T White, K K Bineesh, G B Purushottama, V V Singh, V V Singh, P U Zacharia
The genus Lamiopsis (Carcharhinidae) was previously considered to be monotypic, containing only the Broadfin Shark Lamiopsis temminckii (Müller & Henle, 1839) widely distributed in the Indo-West Pacific. However, a recent taxonomic study revealed that the Western Central Pacific populations were a separate species and that L. temminckii was restricted to the northern Indian Ocean. In this study, the paucity of data available for the true L. temminckii was highlighted. Recently collected specimens of L. temminckii has allowed for a detailed redescription of this species from the northern Arabian Sea to complement the previous taxonomic work on this genus...
October 12, 2016: Zootaxa
https://www.readbyqxmd.com/read/27811760/a-new-subfamily-styracurinae-and-new-genus-styracura-for-himantura%C3%A2-schmardae-werner-1904-and-himantura-pacifica-beebe-tee-van-1941-chondrichthyes-myliobatiformes
#16
Marcelo R De Carvalho, Thiago S Loboda, João Paulo C B Da Silva
A new subfamily (Styracurinae, subfam. nov.) and genus (Styracura, gen. nov.) are erected for Trygon schmardae Werner, 1904 (type species) and Dasyatis pacificus Beebe & Tee-Van, 1941, species placed in Himantura Müller & Henle, 1837 since 1953 but which differ significantly from it and all dasyatid genera in many morphological features. Recent molecular phylogenetic hypotheses based on the entire protein-coding mitochondrial genome have recovered Styracura as the sister group of the Neotropical freshwater stingrays (Potamotrygonidae), agreeing with previous morphological and molecular phylogenies...
October 14, 2016: Zootaxa
https://www.readbyqxmd.com/read/27783350/knee-joint-kinematics-with-dynamic-augmentation-of-primary-anterior-cruciate-ligament-repair-a-biomechanical-study
#17
Janosch Häberli, Philipp Henle, Yves P Acklin, Ivan Zderic, Boyko Gueorguiev
BACKGROUND: Dynamic augmentation of anterior cruciate ligament tears seems to reduce anteroposterior knee translation close to the pre-injury level. The aim of the present study is to biomechanically investigate the course of translation during a simulated early post-operative phase. It is hypothesized that anteroposterior translation is maintained at the immediate post-operative level over a simulated rehabilitation period of 50'000 gait cycles. METHODS: Eight fresh-frozen human cadaveric knee joints from donors with a mean age of 35...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27775222/monitoring-macular-pigment-changes-in-macular-holes-using-fluorescence-lifetime-imaging-ophthalmoscopy
#18
Lydia Sauer, Sven Peters, Johanna Schmidt, Dietrich Schweitzer, Matthias Klemm, Lisa Ramm, Regine Augsten, Martin Hammer
PURPOSE: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH). METHODS: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated. FAF decays were detected in a short (498-560 nm; ch1) and long (560-720 nm; ch2) wavelength channel...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27748541/a-novel-variant-in-the-slc12a1-gene-in-two-families-with-antenatal-bartter-syndrome
#19
Anders Breinbjerg, Charlotte Siggaard Rittig, Niels Gregersen, Søren Rittig, Jane Hvarregaard Christensen
AIM: Bartter syndrome is an autosomal-recessive inherited disease in which patients present with hypokalaemia and metabolic alkalosis. We present two apparently nonrelated cases with antenatal Bartter syndrome type I, due to a novel variant in the SLC12A1 gene encoding the bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 in the thick ascending limb of the loop of Henle. METHODS: Blood samples were received from the two cases and 19 of their relatives, and deoxyribonucleic acid was extracted...
January 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/27729211/a-new-missense-mutation-in-umod-gene-leads-to-severely-reduced-serum-uromodulin-concentrations-a-tool-for-the-diagnosis-of-uromodulin-associated-kidney-disease
#20
Robin Satanovskij, Alhaddad Bader, Matthias Block, Victor Herbst, Wolfgang Schlumberger, Tobias Haack, Wolfgang Andreas Nockher, Uwe Heemann, Lutz Renders, Christoph Schmaderer, Susanne Angermann, Ming Wen, Thomas Meitinger, Jürgen Scherberich, Dominik Steubl
BACKGROUND: Uromodulin-associated Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD-UMOD) belongs to a group of autosomal dominant inherited diseases caused by mutations in the UMOD gene, which codes for uromodulin, a protein exclusively expressed in renal tubular cells of the ascending limb of the loop of Henle. The diagnosis is hampered by non-specific clinical, laboratory and histological findings. In this study, we evaluated serum uromodulin as diagnostic marker for ADTKD-UMOD in a family with a novel mutation in UMOD...
October 10, 2016: Clinical Biochemistry
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