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https://www.readbyqxmd.com/read/27926554/intraoperative-archive-of-right-colonic-vascular-variability-aids-central-vascular-ligation-and-redefines-gastrocolic-trunk-of-henle-variants
#1
Jamal F Alsabilah, Syed A Razvi, Mahdi H Albandar, Nam K Kim
BACKGROUND: Vascular supply to the right colon has become an issue because of high variability and subsequent impact on minimally invasive surgery. Past cadaveric or radiologic anatomic assessments are noncomprehensive. OBJECTIVE: Intraoperative charting of right colonic arteriovenous anatomy was undertaken to determine the incidence and scope of vascular variations. DESIGN: Vascular anatomy variations were documented in snapshot images, captured during laparoscopic video recordings or through open surgical digital photography...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27924355/avp-dynamically-increases-paracellular-na-permeability-and-transcellular-nacl-transport-in-the-medullary-thick-ascending-limb-of-henle-s-loop
#2
REVIEW
Nina Himmerkus, Allein Plain, Rita D Marques, Svenja R Sonntag, Alexander Paliege, Jens Leipziger, Markus Bleich
The medullary thick ascending limb of Henle's loop (mTAL) is crucial for urine-concentrating ability of the kidney. It is water tight and able to dilute the luminal fluid by active transcellular NaCl transport, fueling the counter current mechanism by increasing interstitial osmolality. While chloride is exclusively transported transcellularly, approx. 50% of sodium transport occurs via the paracellular route, driven by the lumen-positive transepithelial potential. Antidiuretic hormone (AVP) is known to increase active NaCl transport to support collecting duct water reabsorption...
December 6, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27920129/chronic-inhibition-of-renal-outer-medullary-potassium-channel-not-only-prevented-but-also-reversed-development-of-hypertension-and-end-organ-damage-in-dahl-salt-sensitive-rats
#3
Xiaoyan Zhou, Michael J Forrest, Wanda Sharif-Rodriguez, Gail Forrest, Daphne Szeto, Olga Urosevic-Price, Yonghua Zhu, Andra S Stevenson, Yuchen Zhou, Sloan Stribling, Maya Dajee, Shawn P Walsh, Alexander Pasternak, Kathleen A Sullivan
The renal outer medullary potassium (ROMK) channel mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Evidence from the phenotype of humans and rodents with functional ROMK deficiency supports the contention that selective ROMK inhibitors (ROMKi) will represent a novel diuretic with potential of therapeutic benefit for hypertension. ROMKi have recently been synthesized by Merck & Co, Inc...
December 5, 2016: Hypertension
https://www.readbyqxmd.com/read/27906863/bartter-s-and-gitelman-s-syndrome
#4
Hannsjörg W Seyberth, Stefanie Weber, Martin Kömhoff
PURPOSE OF REVIEW: The clinical presentations of Bartter's syndrome and Gitelman's syndrome will be reviewed including two most recently described hypokalemic salt-losing tubulopathies. By taking the quite heterogeneous presentations and the apparently different pathophysiologies as the basis, the applicability of the physiologic classification has been tested. RECENT FINDINGS: According to the physiologic approach, salt-losing tubulopathies can be divided into two major groups (with completely different tubular defects): first, disorders of the thick ascending limb of Henle's loop (loop disorders); second, disorders of the distal convolute tubule (DCT disorders)...
November 30, 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27900834/transformation-of-free-and-dipeptide-bound-glycated-amino-acids-by-two-strains-of-saccharomyces-cerevisiae
#5
Michael Hellwig, Marie Börner, Falco Beer, Karl-Heinz van Pée, Thomas Henle
The yeast Saccharomyces cerevisiae transforms branched-chain and aromatic amino acids to higher alcohols in the Ehrlich pathway. During microbiological culturing and industrial fermentations, this yeast is confronted with amino acids modified by reducing sugars in the Maillard reaction (glycation). In order to get first insights into the physiological "handling" of glycated amino acids by yeasts, individual Maillard reaction products (MRPs; fructosyllysine, carboxymethyllysine, pyrraline, formyline, maltosine, methylglyoxal-derived hydroimidazolone) were administered to two strains of S...
November 30, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27811793/parasitic-copepods-infesting-the-olfactory-sacs-of-skates-from-the-southwestern-atlantic-with-the-description-of-a-new-species-of-kroeyerina-wilson-1932
#6
Manuel M Irigoitia, Delfina M P Cantatore, Inés S Incorvaia, Juan T Timi
The olfactory sacs of 488 specimens belonging to 18 species of rajid and arhynchobatid skates from the Argentine Sea were sampled for parasites. No parasitic copepods were found in 11 host species, but siphonostomatoid specimens referable to Kroeyerina Wilson, 1932 (Kroyeriidae) and Brianella corniger Wilson, 1915 (Lernaeopodidae) were found on the spotback skate Atlantoraja castelnaui (Miranda Ribeiro, 1907), the smallnose fanskate Sympterygia bonapartii Müller & Henle, 1841, the bignose fanskate Sympterygia acuta Garman, 1877 and the zipper sand skate Psammobatis extenta (Garman, 1913) (Rajiformes: Arhynchobatidae)...
October 11, 2016: Zootaxa
https://www.readbyqxmd.com/read/27811779/redescription-of-the-rare-and-endangered-broadfin-shark-lamiopsis-temminckii-m%C3%A3-ller-henle-1839-carcharhiniformes-carcharhinidae-from-the-northeastern-arabian-sea
#7
K V Akhilesh, W T White, K K Bineesh, G B Purushottama, V V Singh, V V Singh, P U Zacharia
The genus Lamiopsis (Carcharhinidae) was previously considered to be monotypic, containing only the Broadfin Shark Lamiopsis temminckii (Müller & Henle, 1839) widely distributed in the Indo-West Pacific. However, a recent taxonomic study revealed that the Western Central Pacific populations were a separate species and that L. temminckii was restricted to the northern Indian Ocean. In this study, the paucity of data available for the true L. temminckii was highlighted. Recently collected specimens of L. temminckii has allowed for a detailed redescription of this species from the northern Arabian Sea to complement the previous taxonomic work on this genus...
October 12, 2016: Zootaxa
https://www.readbyqxmd.com/read/27811760/a-new-subfamily-styracurinae-and-new-genus-styracura-for-himantura%C3%A2-schmardae-werner-1904-and-himantura-pacifica-beebe-tee-van-1941-chondrichthyes-myliobatiformes
#8
Marcelo R De Carvalho, Thiago S Loboda, João Paulo C B Da Silva
A new subfamily (Styracurinae, subfam. nov.) and genus (Styracura, gen. nov.) are erected for Trygon schmardae Werner, 1904 (type species) and Dasyatis pacificus Beebe & Tee-Van, 1941, species placed in Himantura Müller & Henle, 1837 since 1953 but which differ significantly from it and all dasyatid genera in many morphological features. Recent molecular phylogenetic hypotheses based on the entire protein-coding mitochondrial genome have recovered Styracura as the sister group of the Neotropical freshwater stingrays (Potamotrygonidae), agreeing with previous morphological and molecular phylogenies...
October 14, 2016: Zootaxa
https://www.readbyqxmd.com/read/27783350/knee-joint-kinematics-with-dynamic-augmentation-of-primary-anterior-cruciate-ligament-repair-a-biomechanical-study
#9
Janosch Häberli, Philipp Henle, Yves P Acklin, Ivan Zderic, Boyko Gueorguiev
BACKGROUND: Dynamic augmentation of anterior cruciate ligament tears seems to reduce anteroposterior knee translation close to the pre-injury level. The aim of the present study is to biomechanically investigate the course of translation during a simulated early post-operative phase. It is hypothesized that anteroposterior translation is maintained at the immediate post-operative level over a simulated rehabilitation period of 50'000 gait cycles. METHODS: Eight fresh-frozen human cadaveric knee joints from donors with a mean age of 35...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27775222/monitoring-macular-pigment-changes-in-macular-holes-using-fluorescence-lifetime-imaging-ophthalmoscopy
#10
Lydia Sauer, Sven Peters, Johanna Schmidt, Dietrich Schweitzer, Matthias Klemm, Lisa Ramm, Regine Augsten, Martin Hammer
PURPOSE: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH). METHODS: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated. FAF decays were detected in a short (498-560 nm; ch1) and long (560-720 nm; ch2) wavelength channel...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27748541/a-novel-variant-in-the-slc12a1-gene-in-two-families-with-antenatal-bartter-syndrome
#11
Anders Breinbjerg, Charlotte Siggaard Rittig, Niels Gregersen, Søren Rittig, Jane Hvarregaard Christensen
AIM: Bartter syndrome is an autosomal recessive inherited disease in which patients present with hypokalaemia and metabolic alkalosis. We present two apparently non-related cases with antenatal Bartter syndrome type I, due to a novel variant in the SLC12A1 gene encoding the bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 in the thick ascending limb of the loop of Henle. METHODS: Blood samples were received from the two cases and 19 of their relatives and deoxyribonucleic acid was extracted...
October 17, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27729211/a-new-missense-mutation-in-umod-gene-leads-to-severely-reduced-serum-uromodulin-concentrations-a-tool-for-the-diagnosis-of-uromodulin-associated-kidney-disease
#12
Robin Satanovskij, Alhaddad Bader, Matthias Block, Victor Herbst, Wolfgang Schlumberger, Tobias Haack, Wolfgang Andreas Nockher, Uwe Heemann, Lutz Renders, Christoph Schmaderer, Susanne Angermann, Ming Wen, Thomas Meitinger, Jürgen Scherberich, Dominik Steubl
BACKGROUND: Uromodulin-associated Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD-UMOD) belongs to a group of autosomal dominant inherited diseases caused by mutations in the UMOD gene, which codes for uromodulin, a protein exclusively expressed in renal tubular cells of the ascending limb of the loop of Henle. The diagnosis is hampered by non-specific clinical, laboratory and histological findings. In this study, we evaluated serum uromodulin as diagnostic marker for ADTKD-UMOD in a family with a novel mutation in UMOD...
October 10, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27707705/a-computational-model-for-simulating-solute-transport-and-oxygen-consumption-along-the-nephrons
#13
Anita T Layton, Volker Vallon, Aurélie Edwards
The goal of this study was to investigate water and solute transport, with a focus on sodium transport (T$_{\rm Na}$) and metabolism along individual nephron segments under differing physiological and pathophysiological conditions. To accomplish this goal, we developed a computational model of solute transport and oxygen consumption (Q$_{\rm O2}$) along different nephron populations of a rat kidney. The model represents detailed epithelial and paracellular transport processes along both the superficial and juxtamedullary nephrons, with the loop of Henle of each model nephron extending to differing depths of the inner medulla...
October 5, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27701299/two-new-and-one-redescribed-species-of-acanthobothrium%C3%A2-cestoda-onchoproteocephalidea-onchobothriidae-from-dasyatis-akajei-myliobatiformes-dasyatidae-in-the-china-sea
#14
Chaopin Yang, Yuan Sun, Tingting Zhi, Takashi Iwaki, Florian B Reyda, Tingbao Yang
Acanthobothrium ningdense n. sp. and Acanthobothrium guanghaiense n. sp. are described from the spiral intestine of the whip stingray, Dasyatis akajei (Müller & Henle). Acanthobothrium ningdense n. sp. is reported based on 38 cestode specimens collected at five locations along the Chinese coast, i.e. Taizhou, Zhejiang Province, Ningde and Xiamen, Fujian Province, Taishan, Guangdong Province and Sanya, Hainan Province between 2012 and 2015. Acanthobothrium ningdense n. sp. belongs to the "species category 4" characterised by Ghoshroy & Caira...
September 20, 2016: Zootaxa
https://www.readbyqxmd.com/read/27689335/co-application-of-canavanine-and-irradiation-uncouples-anticancer-potential-of-arginine-deprivation-from-citrulline-availability
#15
Yuliya Kurlishchuk, Bozhena Vynnytska-Myronovska, Philipp Grosse-Gehling, Yaroslav Bobak, Friederike Manig, Oleg Chen, Sebastian R Merker, Thomas Henle, Steffen Löck, Daniel E Stange, Oleh Stasyk, Leoni A Kunz-Schughart
The moderate anticancer effect of arginine deprivation in clinical trials has been linked to an induced argininosuccinate synthetase (ASS1) expression in initially ASS1-negative tumors, and ASS1-positive cancers are anticipated as non-responders. Our previous studies indicated that arginine deprivation and low doses of the natural arginine analog canavanine can enhance radioresponse. However, the efficacy of the proposed combination in the presence of extracellular citrulline, the substrate for arginine synthesis by ASS1, remains to be elucidated, in particular for malignant cells with positive and/or inducible ASS1 as in colorectal cancer (CRC)...
September 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27613513/a-missense-mutation-in-solute-carrier-family-12-member-1-slc12a1-causes-hydrallantois-in-japanese-black-cattle
#16
Shinji Sasaki, Kiyotoshi Hasegawa, Tomoko Higashi, Yutaka Suzuki, Sumio Sugano, Yasuaki Yasuda, Yoshikazu Sugimoto
BACKGROUND: Hydrallantois is the excessive accumulation of fluid within the allantoic cavity in pregnant animals and is associated with fetal mortality. Although the incidence of hydrallantois is very low in artificial insemination breeding programs in cattle, recently 38 cows with the phenotypic appearance of hydrallantois were reported in a local subpopulation of Japanese Black cattle. Of these, 33 were traced back to the same sire; however, both their parents were reported healthy, suggesting that hydrallantois is a recessive inherited disorder...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27599528/diuretic-action-of-sodium-glucose-cotransporter-2-inhibitors-and-its-importance-in-the-management-of-heart-failure
#17
Genjiro Kimura
Primarily, the sodium-glucose cotransporter 2 (SGLT2) inhibitors suppress the cotransport of glucose and sodium from the tubular lumen of the proximal tubules to the blood, and excrete glucose into the urine. Therefore, glucose and caloric balances become negative, reducing both the blood glucose level and insulin secretion. On the other hand, the proximal tubular fluid, constituted with low chloride concentration because of SGLT2 inhibition, is transferred to the loop of Henle. Under low chloride conditions, the reabsorption mechanisms in the loop of Henle do not work, similar to when loop diuretics are given...
September 7, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27594145/free-and-protein-bound-maillard-reaction-products-in-beer-method-development-and-a-survey-of-different-beer-types
#18
Michael Hellwig, Sophia Witte, Thomas Henle
The Maillard reaction is important for beer color and flavor, but little is known about the occurrence of individual glycated amino acids in beer. Therefore, seven Maillard reaction products (MRPs), namely, fructosyllysine, maltulosyllysine, pyrraline, formyline, maltosine, MG-H1, and argpyrimidine, were synthesized and quantitated in different types of beer (Pilsner, dark, bock, wheat, and nonalcoholic beers) by HPLC-ESI-MS/MS in the multiple reaction monitoring mode through application of the standard addition method...
September 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27543138/multiple-cryptic-species-in-the-blue-spotted-maskray-myliobatoidei-dasyatidae-neotrygon-spp-an-update
#19
Philippe Borsa, Kang-Ning Shen, Irma S Arlyza, Thierry B Hoareau
Previous investigations have uncovered divergent mitochondrial clades within the blue-spotted maskray, previously Neotrygon kuhlii (Müller and Henle). The hypothesis that the blue-spotted maskray may consist of a complex of multiple cryptic species has been proposed, and four species have been recently described or resurrected. To test the multiple cryptic species hypothesis, we investigated the phylogenetic relationships and coalescence patterns of mitochondrial sequences in a sample of 127 new individuals from the Indian Ocean and the Coral Triangle region, sequenced at both the CO1 and cytochrome b loci...
September 2016: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/27536695/potassium-from-physiology-to-clinical-implications
#20
REVIEW
Miriam Zacchia, Maria Luisa Abategiovanni, Spiros Stratigis, Giovambattista Capasso
BACKGROUND: Potassium (K(+)) is the major intracellular cation, with 98% of the total pool being located in the cells at a concentration of 140-150 mmol/l, and only 2% in the extracellular fluid, where it ranges between 3.5 and 5 mmol/l. A fine regulation of the intracellular-extracellular gradient is crucial for life, as it is the main determinant of membrane voltage; in fact, acute changes of K(+) plasma levels may have fatal consequences. SUMMARY: An integrated system including an 'internal' and 'external' control prevents significant fluctuations of plasma levels in conditions of K(+) loading and depletion...
June 2016: Kidney Diseases
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