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https://www.readbyqxmd.com/read/28643308/-anatomical-strategies-of-henle-trunk-in-laparoscopic-right-hemi-colectomy-for-right-colon-cancer
#1
Bo Feng, Xialin Yan, Sen Zhang, Pei Xue, Zirui He, Minhua Zheng
The advancement of laparoscopic surgery serves as a trigger for better understanding of the vascular structure at the inferior border of the pancreas, especially Henle trunk. Henle trunk was first found as convergence to superior mesenteric vein (SMV) conjoined by sub-right colon vein (SRCV) and right gastroepiploic vein (RGEV), but decades later, anterior superior pancreatic duodenal vein (ASPDV) was described as another conjoint vein of Henle trunk. These tributaries are the basic elements of Henle trunk in early years' study...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28623232/the-ring-finger-and-pdz-domain-containing-protein-pdzrn3-controls-localization-of-the-mg-2-regulator-claudin-16-in-renal-tube-epithelial-cells
#2
Kana Marunaka, Chisa Furukawa, Naoko Fujii, Toru Kimura, Takumi Furuta, Toshiyuki Matsunaga, Satoshi Endo, Hajime Hasegawa, Naohiko Anzai, Yasuhiro Yamazaki, Masahiko Yamaguchi, Akira Ikari
Ion exchange in the renal tubules is fundamental to the maintenance of physiological ion levels. Claudin-16 (CLDN16) regulates the paracellular reabsorption of Mg(2+) in the thick ascending limb of Henle's loop in the kidney, with dephosphorylation of CLDN16 increasing its intracellular distribution and decreasing paracellular Mg(2+) permeability. CLDN16 is located in the tight junctions, but the mechanism regulating its localization is unclear. Using yeast two-hybrid systems, we found that CLDN16 binds to PDZRN3, a protein containing both RING-finger and PDZ-domains...
June 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28617689/paracellular-transport-and-energy-utilization-in-the-renal-tubule
#3
Alan S L Yu
PURPOSE OF REVIEW: Paracellular transport across the tight junction is a general mechanism for transepithelial transport of solutes in epithelia, including the renal tubule. However, why paracellular transport evolved, given the existence of a highly versatile system for transcellular transport, is unknown. RECENT FINDINGS: Recent studies have identified the paracellular channel, claudin-2, that is responsible for paracellular reabsorption of sodium in the proximal renal tubule...
June 14, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28614118/the-renal-response-to-potassium-stress-integrating-past-with-present
#4
Cary R Boyd-Shiwarski, Arohan R Subramanya
PURPOSE OF REVIEW: The current review combines past findings with recent advances in our understanding of the homeostatic response to potassium imbalance. RECENT FINDINGS: Following the ingestion of a dietary potassium load, a combination of extrarenal and renal mechanisms act to maintain extracellular K+ within a tight window. Through hormonal regulation and direct K+ sensing, the nephron is ideally suited to respond to wide shifts in external K+ balance. Current evidence indicates that dietary K+ loading triggers a coordinated kaliuretic response that appears to involve voltage-dependent changes in sodium transport across multiple nephron segments, including the proximal tubule, medullary loop of Henle, and distal tubule...
June 12, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28598867/pathophysiology-of-antenatal-bartter-s-syndrome
#5
Martin Kömhoff, Kamel Laghmani
PURPOSE OF REVIEW: Antenatal Bartter syndrome (aBS) is a heterogenous disease resulting from defective ion transport in the thick ascending limb of the loop of Henle. Novel insights into the pathophysiology, as well as the recent identification of a novel genetic cause of aBS, merit an update on this topic. RECENT FINDINGS: In aBS, severe salt losing is further aggravated by defective salt sensing in the macula densa, where a reduced tubular salt concentration is perceived and glomerular filtration is increased instead of decreased...
June 8, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28597847/mapping-the-fine-structure-of-cortical-activity-with-different-micro-ecog-electrode-array-geometries
#6
Xi Wang, Alexis Gkogkidis, Olga Iljina, Lukas Fiederer, Chiristian Henle, Irina Mader, Jan Kaminsky, Thomas Stieglitz, Mortimer Gierthmuehlen, Tonio Ball
OBJECTIVE: Innovations in micro-electrocorticography (µECoG) electrode array manufacturing now allow for intricate designs with smaller contact diameters and/or pitch (i.e., center-to-center contact distance) down to the sub-mm range. The aims of the present study were: (i) to investigate whether frequency ranges up to 400 Hz can be reproducibly observed in µECoG recordings and (ii) to examine how differences in topographical substructure between these frequency bands and electrode array geometries can be quantified...
June 9, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28596736/claudin-loss-of-function-disrupts-tight-junctions-and-impairs-amelogenesis
#7
Claire Bardet, Sandy Ribes, Yong Wu, Mamadou Tidiane Diallo, Benjamin Salmon, Tilman Breiderhoff, Pascal Houillier, Dominik Müller, Catherine Chaussain
Claudins are a family of proteins that forms paracellular barriers and pores determining tight junctions (TJ) permeability. Claudin-16 and -19 are pore forming TJ proteins allowing calcium and magnesium reabsorption in the thick ascending limb of Henle's loop (TAL). Loss-of-function mutations in the encoding genes, initially identified to cause Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis (FHHNC), were recently shown to be also involved in Amelogenesis Imperfecta (AI). In addition, both claudins were expressed in the murine tooth germ and Claudin-16 knockout (KO) mice displayed abnormal enamel formation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28589390/-unloading-with-insoles-orthotics-and-braces-pre-operative-leg-axis-correction-or-independent-treatment
#8
REVIEW
M Kess, C Stärke, P Henle
BACKGROUND: Knee osteoarthritis (OA) is a leading joint disease. In most of the early stages it does not involve the whole knee joint. Often, symptoms only or mainly concern the medial compartment combined with a slight varus malalignment. OBJECTIVES: Do valgus braces or laterally wedged insoles influence biomechanics and thus improve pain and function in patients with medial OA? Does the OA grade, severity of malalignment or patient's body weight predict the efficacy of the above-mentioned conservative treatment options? MATERIALS AND METHODS: The current literature was reviewed in regard to biomechanical changes to joint loading and their correlation to clinical results...
June 6, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28579836/update-on-the-renal-toxicity-of-iodinated-contrast-drugs-used-in-clinical-medicine
#9
REVIEW
Michele Andreucci, Teresa Faga, Raffaele Serra, Giovambattista De Sarro, Ashour Michael
An important side effect of diagnostic contrast drugs is contrast-induced acute kidney injury (CI-AKI; a sudden decrease in renal function) occurring 48-72 hours after injection of a contrast drug that cannot be attributed to other causes. Its existence has recently been challenged, because of some retrospective studies in which the incidence of AKI was not different between subjects who received a contrast drug and those who did not, even using propensity score matching to prevent selection bias. For some authors, only patients with estimated glomerular filtration rate <30 mL/min/1...
2017: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/28523340/patient-and-surgical-characteristics-that-affect-revision-risk-in-dynamic-intraligamentary-stabilization-of-the-anterior-cruciate-ligament
#10
Philipp Henle, Kathrin S Bieri, Manuel Brand, Emin Aghayev, Jessica Bettfuehr, Janosch Haeberli, Martina Kess, Stefan Eggli
PURPOSE: Failure of dynamic intraligamentary stabilization (DIS) that requires revision surgery of the anterior cruciate ligament (ACL) has not been studied. The aim of this study was to investigate the incidence of revision ACL surgery, and the patient characteristics and surgery-related factors that are associated with an increased risk of ACL revision after DIS. METHODS: This study analysed a prospective, consecutively documented single-centre case series using standardized case report forms over a 2...
May 18, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28462928/erratum-setting-temporal-baselines-for-biodiversity-the-limits-of-available-monitoring-data-for-capturing-the-full-impact-of-anthropogenic-pressures
#11
Jean-Baptiste Mihoub, Klaus Henle, Nicolas Titeux, Lluís Brotons, Neil A Brummitt, Dirk S Schmeller
No abstract text is available yet for this article.
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28457645/toxicological-and-thermoregulatory-effects-of-feather-contamination-with-artificially-weathered-mc-252-oil-in-western-sandpipers-calidris-mauri
#12
Ivan Maggini, Lisa V Kennedy, Steven J Bursian, Karen M Dean, Alexander R Gerson, Kendal E Harr, Jane E Link, Chris A Pritsos, Karen L Pritsos, Christopher G Guglielmo
The external contamination of bird feathers with crude oil might have effects on feather structure and thus on thermoregulation. We tested the thermoregulatory ability of western sandpipers (Calidris mauri) in a respirometry chamber with oil applied either immediately prior, or three days before the experiment. The birds were then exposed to a sliding cold temperature challenge between 27°C and -3°C to calculate thermal conductance. After the experiment, a large blood sample was taken and the liver extracted to measure a range of parameters linked to toxicology and oxidative stress...
April 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28437467/mutant-uromodulin-expression-leads-to-altered-homeostasis-of-the-endoplasmic-reticulum-and-activates-the-unfolded-protein-response
#13
Céline Schaeffer, Stefania Merella, Elena Pasqualetto, Dejan Lazarevic, Luca Rampoldi
Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively produced by renal epithelial cells lining the thick ascending limb of Henle's loop (TAL) and it plays key roles in kidney function and disease. Mutations in UMOD, the gene encoding uromodulin, cause autosomal dominant tubulointerstitial kidney disease uromodulin-related (ADTKD-UMOD), characterised by hyperuricemia, gout and progressive loss of renal function. While the primary effect of UMOD mutations, retention in the endoplasmic reticulum (ER), is well established, its downstream effects are still largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28428858/genetic-diversity-and-spatial-structure-of-the-rufous-throated-antbird-gymnopithys-rufigula-an-amazonian-obligate-army-ant-follower
#14
Juliana Menger, Klaus Henle, William E Magnusson, Antonella Soro, Martin Husemann, Martin Schlegel
Amazonian understory antbirds are thought to be relatively sedentary and to have limited dispersal ability; they avoid crossing forest gaps, and even narrow roads through a forest may limit their territories. However, most evidence for sedentariness in antbirds comes from field observations and plot-based recapture of adult individuals, which do not provide evidence for lack of genetic dispersal, as this often occurs through juveniles. In this study, we used microsatellite markers and mitochondrial control-region sequences to investigate contemporary and infer historical patterns of genetic diversity and structure of the Rufous-throated Antbird (Gymnopithys rufigula) within and between two large reserves in central Amazonia...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28426631/directional-changes-in-tissue-reflectivity-may-influence-flow-detection-on-optical-coherence-tomography-angiography
#15
Rosa Dolz-Marco, K Bailey Freund
PURPOSE: To determine if directional or anatomical changes in tissue reflectivity of Henle fiber layer (HFL) may influence flow detection on optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional analysis of consecutive cases undergoing OCT-A. Directional changes in visualization of HFL were either produced manually by moving the beam entrance within the pupil or observed occurring naturally because of tilting of the OCT line-scan within a myopic staphyloma...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28415841/unique-pattern-of-protein-bound-maillard-reaction-products-in-manuka-leptospermum-scoparium-honey
#16
Michael Hellwig, Jana Rückriemen, Daniel Sandner, Thomas Henle
As a unique feature, honey from the New Zealand manuka tree (Leptospermum scoparium) contains substantial amounts of dihydroxyacetone (DHA) and methylglyoxal (MGO). Although MGO is a reactive intermediate in the Maillard reaction, very little is known about reactions of MGO with honey proteins. We hypothesized that the abundance of MGO should result in a particular pattern of protein-bound Maillard reaction products (MRPs) in manuka honey. A protein-rich high-molecular-weight fraction was isolated from 12 manuka and 8 non-manuka honeys and hydrolyzed enzymatically...
May 3, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28407946/manuka-honey-leptospermum-scoparium-inhibits-jack-bean-urease-activity-due-to-methylglyoxal-and-dihydroxyacetone
#17
Jana Rückriemen, Oliver Klemm, Thomas Henle
Manuka honey (Leptospermum scoparium) exerts a strong antibacterial effect. Bacterial enzymes are an important target for antibacterial compounds. The enzyme urease produces ammonia and enables bacteria to adapt to an acidic environment. A new enzymatic assay, based on photometric detection of ammonia with ninhydrin, was developed to study urease activity. Methylglyoxal (MGO) and its precursor dihydroxyacetone (DHA), which are naturally present in manuka honey, were identified as jack bean urease inhibitors with IC50 values of 2...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28402284/three-new-genera-of-rhinebothriidean-cestodes-from-stingrays-in-southeast-asia
#18
Janine N Caira, Claire J Healy, Fernando P L Marques, Kirsten Jensen
Three genera of rhinebothriideans, previously referred to as New genus 1, New genus 2 and New genus 4, are erected in the the Anthocephaliidae. New genus 1 is established as Divaricobothrium gen. n., with Divaricobothrium tribelum sp. n. as its type species; Echeneibothrium trifidum Shipley et Hornell, 1906 is transferred to the genus as Divaricobothrium trifidum (Shipley et Hornell, 1906) comb. n. This genus is unique among rhinebothriidean genera in bearing bothridia that are posteriorly deeply divided into two lobes with facial loculi but no apical sucker, and a vagina that extends to near the anterior margin of the proglottid...
April 4, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28389525/role-of-renal-transporters-and-novel-regulatory-interactions-in-the-tal-that-control-blood-pressure
#19
REVIEW
Lesley A Graham, Anna F Dominiczak, Nicholas R Ferreri
Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year. Excessive dietary salt intake is among the environmental factors that contribute to HTN, known as salt sensitivity. The heterogeneity of salt sensitivity and the multiple mechanisms that link high salt intake to increases in blood pressure are of upmost importance for therapeutic application. A continual increase in the kidney's reabsorption of sodium (Na(+)) relies on sequential actions at various segments along the nephron...
May 1, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28373577/parathyroid-hormone-controls-paracellular-ca-2-transport-in-the-thick-ascending-limb-by-regulating-the-tight-junction-protein-claudin14
#20
Tadatoshi Sato, Marie Courbebaisse, Noriko Ide, Yi Fan, Jun-Ichi Hanai, Jovana Kaludjerovic, Michael J Densmore, Quan Yuan, Hakan R Toka, Martin R Pollak, Jianghui Hou, Beate Lanske
Renal Ca(2+) reabsorption is essential for maintaining systemic Ca(2+) homeostasis and is tightly regulated through the parathyroid hormone (PTH)/PTHrP receptor (PTH1R) signaling pathway. We investigated the role of PTH1R in the kidney by generating a mouse model with targeted deletion of PTH1R in the thick ascending limb of Henle (TAL) and in distal convoluted tubules (DCTs): Ksp-cre;Pth1r(fl/fl) Mutant mice exhibited hypercalciuria and had lower serum calcium and markedly increased serum PTH levels. Unexpectedly, proteins involved in transcellular Ca(2+) reabsorption in DCTs were not decreased...
April 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
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