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https://www.readbyqxmd.com/read/29749364/cytopenia-in-adult-brucellosis-patients
#1
Safak Kaya, Nazif Elaldi, Ozcan Deveci, Ahmet Emre Eskazan, Muhammed Bekcibasi, Salih Hosoglu
Background & objectives: Brucellosis can lead to haematological abnormalities including cytopenia confusing with haematological malignancies. The aim of this study was to compare the main characteristics of brucellosis patients without cytopenia (Group 1) and with cytopenia (Group 2). Methods: This five-year period study which was performed in two referral hospitals in Turkey, included all adult brucellosis patients. Abnormally, low counts of leucocyte or haemoglobin or platelets in a patient were considered as cytopenia...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29745323/research-progress-on-brucellosis
#2
Yuming Deng, Xinyue Liu, Kaifang Duan, Qisheng Peng
Brucellosis is a debilitating febrile illness caused by an intracellular Brucella. The disease distributed in humans and animals widely, especially in developing countries. Ten species are included in the genus Brucella nowadays; four species of them are pathogenic to humans, which making brucellosis a zoonosis with more than 500,000 new cases reported annually. For human brucellosis, the most pathogenic specie is B. melitensis followed by B. suis, while B. abortus is the mildest type of brucellosis. The infection mechanism of Brucella is complicated and mostly relies on its virulence factors...
May 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29724202/anti-brucella-activity-of-caryopteris-mongolica-bunge-root-extract-against-brucella-melitensis-infection-in-mice
#3
Tsevelmaa N, Narangerel B, Odgerel O, Dariimaa D, Batkhuu J
BACKGROUND: The current treatment for human brucellosis requires a combination of antibiotics for long periods of time, and the reported incidence and prevalence of the disease vary widely in nomadic livestock of Mongolia. The objective of the present study was to evaluate the in vivo antibacterial activity of the C. mongolica root extract against B. melitensis. METHODS: In this study, we used of 6 groups of mice (n = 5). Five groups of BALB/c mice were inoculated intraperitoneally with the M16 strain of B...
May 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29716658/a-case-report-of-spontaneous-abortion-caused-by-brucella-melitensis-biovar-3
#4
Hong-Xia Yang, Jun-Jun Feng, Qiu-Xiang Zhang, Rui-E Hao, Su-Xia Yao, Rong Zhao, Dong-Ri Piao, Bu-Yun Cui, Hai Jiang
BACKGROUND: Brucellosis is a worldwide zoonotic disease caused by Brucella spp. Brucella invades the body through the skin mucosa, digestive tract, and respiratory tract. However, only a few studies on human spontaneous abortion attributable to Brucella have been reported. In this work, the patient living in Shanxi Province in China who had suffered a spontaneous abortion was underwent pathogen detection and Brucella melitensis biovar 3 was identified. CASE PRESENTATION: The patient in this study was 22 years old...
May 2, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29682450/first-case-of-cervical-epidural-abscess-caused-by-brucellosis-in-saudi-arabia-a-case-report-and-literature-review
#5
Meshal Alyousef, Rabia Aldoghaither
Spinal epidural abscess (SEA) is an extremely rare and disastrous musculoskeletal complication of spondylodiscitis and sacroilitis secondary to brucellosis infection. Few case reports and retrospective studies have been published reporting patients with epidural abscesses mainly lumbar, and thoracic while cervical abscess are rare. Management of spinal epidural abscess due to Brucella species is not standard and remains controversial. To the best of our knowledge this is the first case of brucellar cervical epidural abscess reported in Saudi Arabia...
2018: IDCases
https://www.readbyqxmd.com/read/29670827/vasculitis-and-neurobrucellosis-evaluation-of-nine-cases-using-radiologic-findings
#6
Sule Aydin Turkoglu, Siddika Halicioglu, Fatma Sirmatel, Murside Yildiz, Nebil Yildiz, Serpil Yildiz
Background: Brucellosis is an important multisystemic disease with many different clinical symptoms, and its early diagnosis and treatment are possible. Neurobrucellosis (NB) is a rare but serious finding of brucellosis. Brucella can be seen as meningitis and encephalopathy, and it can cause cranial nerve pathologies, vascular syndromes, myopathy, spinal diseases, and psychiatric disorders. In NB, vascular syndromes secondary to inflammation are rarely seen. Here, we present nine young patients with vascular and nonspecific neuropsychiatric findings who had NB as the etiology of stroke...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29623212/first-report-of-lyme-disease-in-nepal
#7
Sher Bahadur Pun, Sumit Agrawal, Santoshananda Jha, Lila Nath Bhandari, Bimal Sharma Chalise, Abadhesh Mishra, Rajesh Shah
Introduction: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi and is widely reported in the USA, Central Europe, South East Asia and Latin America. Until recently, no scientific report regarding Lyme disease in Nepal had been published. Case presentation: A 32-year-old, previously healthy female visited the hospital with a history of joint pains, fatigue, neck stiffness, tingling sensation and headache. She was initially treated for typhoid fever, brucellosis and malaria, but did not show significant improvement...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29621840/brucellosis
#8
Siobhan M Mor, Anke K Wiethoelter, Peter D Massey, Jennifer Robson, Kathryn Wilks, Penny Hutchinson
BACKGROUND: Brucellosis, also known as undulant, Mediterranean or Malta fever, is a systemic infection that causes fever, sweats, arthralgias and myalgias. A globally important disease, brucellosis is re-emerging in Australia in association with feral pig hunting activities. OBJECTIVE: This article aims to provide clinicians with an overview of brucellosis, covering epidemiology, clinical features, diagnosis, management and prevention. DISCUSSION: Brucellosis should be suspected in all patients with non-specific, flu-like illness who fall into one of the major risk groups (feral pig hunters, overseas travellers and migrants)...
March 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29606969/bioassay-directed-isolation-of-quaternary-benzylisoquinolines-from-berberis-integerrima-with-bactericidal-activity-against-brucella-abortus
#9
Gholamhassan Azimi, Ali Hakakian, Mustafa Ghanadian, Ali Joumaa, Saeed Alamian
Berberis integerrima Bonge. (Syn: Berberis densiflora Boiss. & Buhse) is a shrub widely distributed in Middle East and central part of Asia. An ethnobotanical study revealed that indigenous and tribal people in Iran use B. integerrima root decoction for treatment of brucellosis. Therefore, the aim of this study was bioassay directed isolation of antibacterial compounds from this plant based on their in vitro bactericidal activity against Brucella abortus . Briefly, the ethanol extract of B. integerrima was fractioned and subjected to preliminary antibacterial screening tests against Brucella...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29588282/brucellosis-accompanied-by-haemophagocytic-lymphohistiocytosis-and-multiple-splenic-abscesses-in-a-patient-with-depression
#10
Fatehi E Elzein, Nisreen Al Sherbini, Mohammed M Alotaibi, Wassiem M Al-Hassan
A 39-year-old woman was being treated for depression in our clinic. She subsequently developed a fever and was diagnosed with pancytopenia and moderate splenomegaly. Laboratory and bone marrow results, including markedly increased serum ferritin levels, suggested haemophagocytic lymphohistiocytosis. CT showed multiple splenic abscesses and ovarian vein thrombosis. All laboratory values returned to normal after treatment for culture-positive brucellosis.
March 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29563819/a-case-of-brucella-melitensis-endocarditis-in-a-patient-with-cardiovascular-implantable-electronic-device
#11
Wasl Al-Adsani, Ali Ahmad, Mohammad Al-Mousa
Background: Brucellosis is a bacterial infection, caused by the nonmotile gram-negative aerobic coccobacilli. The clinical manifestation of brucellosis is variable, ranging from mild disease to severe disease. The gold standard test to confirm the diagnosis of brucellosis is assaying blood, bone marrow, or other body fluids or by tissue culture. Preferred first-line treatment in adults with uncomplicated, nonlocalized disease consists of doxycycline-aminoglycoside combination. The recommended duration of treatment is 6 weeks...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29560140/pattern-of-childhood-brucellosis-in-najran-south-saudi-arabia-in-2013-2017
#12
Ghadi Mohammed Al Hashan, Nagah Mohamed Abo El-Fetoh, Iman Ali Nasser, Atheer Raja Alyami, Albatool Saleh Hassan Almagbool, Taghreed Ahmad Eidih Hatuwh, Fatimah Hamad Saleh Alyami, Maram Hamad Al Yami, Manar Hamad Alqahtani, Nouf Mubarak Ali Almardhamah, Tahani Mohammed Alanazi, Wafaa Mohamed Bakr Ali, Ahad Mesfer Halzaa, Ayah Abdullah Alshehri
Background: With more than 500,000 new cases annually, human brucellosis is the commonest zoonotic disease worldwide. In some endemic countries, its prevalence is more than 10 per 100,000 population. Objective: The aim of this study was to determine the magnitude of the problem and the clinical features, laboratory findings, treatment given and complications seen in children with brucellosis in Najran City, Kingdom of Saudi Arabia. Methods: This is a case-series study by analysis of data of children known or diagnosed to have brucellosis for the last 4 years in Najran City...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29519244/acute-liver-failure-complication-of-brucellosis-infection-a-case-report-and-review-of-the-literature
#13
Julio César García Casallas, Walter Villalobos Monsalve, Sara Consuelo Arias Villate, Ingrid Marisol Fino Solano
BACKGROUND: Brucellosis is one of the most widespread zoonoses worldwide. It can affect any organ system, particularly the gastrointestinal system, but there is no report of acute liver failure as a brucellosis complication. CASE PRESENTATION: We present a case of acute liver failure secondary to brucellosis infection. A 75-year-old Hispanic man presented to a University Hospital in Chía, Colombia, with a complaint of 15 days of fatigue, weakness, decreased appetite, epigastric abdominal pain, jaundice, and 10 kg weight loss...
March 9, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29495161/-study-on-antimicrobial-susceptibility-of-brucella-in-a-city
#14
S W Zuo, Z L Ni, Y B Yao, R S Yang, S K Wang, Y H Zhou
Objective: To investigate the antimicrobial susceptibility of Brucella and to provide a scientific basis for rational drug use and effective treatment of patients with brucellosis. Methods: A total of 41 Brucella strains were isolated from the blood of patients with brucellosis in 5 counties and 2 districts in Yuxi City, China from 2014 to 2016. The susceptibility to 23 antimicrobial drugs was tested using Kirby-Bauer (K-B) disk diffusion method and the sizes of antimicrobial rings were recorded. The susceptibility testing results were interpreted according to the Drug Susceptibility Testing Guideline (2009 version) ...
December 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29462155/rifampicin-versus-streptomycin-for-brucellosis-treatment-in-humans-a-meta-analysis-of-randomized-controlled-trials
#15
Fanjie Meng, Xiangpo Pan, Wenzhen Tong
Brucellosis is a zoonotic disease with a high morbidity in developing countries, but there the optimal treatment is not yet determined. Therefore, the development of a simple and effective treatment is important. The aim of this study was to summarize the available evidences and compare rifampicin with streptomycin in human brucellosis with doxycycline as background regimen. We systematically searched PubMed, EmBase, and the Cochrane Library from their inception up through December 2016. We included studies with a randomized controlled design that evaluated the effect of streptomycin compared with rifampicin in human brucellosis patients who received doxycycline therapy as background regimen...
2018: PloS One
https://www.readbyqxmd.com/read/29434601/inhibition-of-osteoblast-function-by-brucella-abortus-is-reversed-by-dehydroepiandrosterone-and-involves-erk1-2-and-estrogen-receptor
#16
María Virginia Gentilini, Ayelén Ivana Pesce Viglietti, Paula Constanza Arriola Benitez, Andrea Elena Iglesias Molli, Gloria Edith Cerrone, Guillermo Hernán Giambartolomei, María Victoria Delpino
Brucella abortus induces an inflammatory response that stimulates the endocrine system resulting in the secretion of cortisol and dehydroepiandrosterone (DHEA). Osteoarticular brucellosis is the most common presentation of the active disease in humans, and we have previously demonstrated that B. abortus infection inhibits osteoblast function. We aimed to evaluate the role of cortisol and DHEA on osteoblast during B. abortus infection. B. abortus infection induces apoptosis and inhibits osteoblast function. DHEA treatment reversed the effect of B...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29427095/rifampicin-induced-fever-in-a-patient-with-brucellosis-a-case-report
#17
Mesut Yilmaz, Canan Yasar, Selda Aydin, Okan Derin, Bahadir Ceylan, Ali Mert
We present a 35-year-old female patient who was started on rifampicin (900 mg orally once daily) and trimethoprim/sulfamethoxazole (TMP/SMX) (160/800 mg orally twice daily) after being diagnosed with brucellosis. Following defervescence and improvement in her general condition, fever recurred on the 12th day of treatment. A re-challenge drug test lead to causality assessment and treatment was switched to a combination of streptomycin (1 g intramuscularly) for 10 days and TMP/SMX (160/800 mg orally twice daily) for 4 weeks...
February 9, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29384559/neurobrucellosis-diagnostic-and-clinical-management-of-an-atypical-case
#18
Marco Rossi, Carlo Tascini, Novella Carannante, Giovanni Di Caprio, Sonia Sofia, Carmelo Iacobello
Brucellosis is the most common zoonosis in the world and it is caused by ingestion of foods contaminated by Brucella spp. that is able to avoid the immune system and can involve every organ system. The bacteria may affect the Central Nervous System (CNS) directly or using phagocytic cells with the way of the "Trojan Horse Model". Meningitis is the most common form of neuro-brucellosis (NB) but other neurological manifestation, with variable onset, such as severe encephalic involvement, neuropathy, vascular damage, radiculitis and hydrocephalus might happened...
January 31, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29344838/association-between-human-brucellosis-and-adverse-pregnancy-outcome-a-cross-sectional-population-based-study
#19
Nesrin Ghanem-Zoubi, Silvia Pessah Eljay, Emilia Anis, Mical Paul
To investigate the association between the incidence of human brucellosis (HB) and adverse pregnancy outcomes (APOs), a population-based, cross-sectional aggregate data study was conducted in Israel between 2010 and 2014. HB-endemic localities were matched by ethnicity, population size and socioeconomic status to localities with a low incidence of HB. We compared APO rates in high-incidence vs low-incidence localities. The primary outcome was intrauterine fetal demise (IUFD). Secondary outcomes were premature birth (less than 37 weeks), early or threatened labour and poor fetal growth...
January 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29343543/an-autoimmune-disease-associated-risk-variant-in-the-tnfaip3-gene-plays-a-protective-role-in-brucellosis-that-is-mediated-by-the-nf-kappa-b-signaling-pathway
#20
Lixin Lou, Wanguo Bao, Xianjun Liu, Hongxiao Song, Yang Wang, Kaiyu Zhang, Wenjing Gao, Haijun Li, Zhengkun Tu, Shaofeng Wang
Naturally occurring functional variants (rs148314165 and rs200820567, collectively referred to as TT>A) reduce the expression of the tumor necrosis factor α-induced protein 3 (TNFAIP3) gene, a negative regulator of NF-κB signaling, and predispose individuals to autoimmune disease. In this analysis, we conducted a genetic association study of the TT>A variants in 1209 controls and in 150 patients with brucellosis, an infectious disease, and further assessed the role of the variants in brucellosis. Our data demonstrated that the TT>A variants were correlated with cases of brucellosis (P = 0...
January 17, 2018: Journal of Clinical Microbiology
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