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brucellosis treatment

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https://www.readbyqxmd.com/read/28812192/safety-of-vaccination-against-brucellosis-with-the-rough-strain-in-pregnant-cattle
#1
Adriana Agostini Barbosa, Ana Cristina Silva Figueiredo, Miller Pereira Palhao, Joao Henrique Moreira Viana, Carlos Antonio Carvalho Fernandes
Brucellosis is an infectious and contagious disease that profoundly impacts public health. However, in many countries, disease prevention is restricted to the vaccination of calves, and there is no prophylactic strategy for pregnant heifers and cows. The aim of this study was to evaluate the safety of the rough strain vaccine against brucellosis in pregnant cattle. Crossbred cows (N = 96) at three gestational periods (early, mid, or late pregnancy) were randomly allocated into the vaccine treatment group or to the control group...
August 15, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28768443/neurobrucellosis
#2
Na Zheng, Wei Wang, Jia-Tang Zhang, Ya Cao, Long Shao, Jiao-Jiao Jiang, Xu-Sheng Huang, Cheng-Lin Tian, Sheng-Yuan Yu
Neurobrucellosis (NB) is a rare complication of brucellosis. NB presents with a variety of clinical manifestations, and the symptoms are always atypical. Our aim was to analyze the demographic characteristics, clinical manifestations, laboratory findings, imaging findings, treatments and outcomes of patients with NB. We retrospectively reviewed the data from 17 patients with NB hospitalized at the Chinese People's Liberation Army General Hospital between January 1, 2005 and October 31, 2016. The following symptoms were recorded: 10/17 (59%) patients had fever, and 9/17 (53%) patients had a disorder affecting urination and defecation...
August 3, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28766326/a-review-of-brucellosis-in-iran-epidemiology-risk-factors-diagnosis-control-and-prevention
#3
Maryam Golshani, Saeid Buozari
Brucellosis caused by species of Brucella is among the most prevalent zoonoses with the annual incidence of half a million cases globally. Most parts of Iran are endemic for brucellosis, and the annual incidence of the human and animal brucellosis is still high. At present, there is no safe and protective human vaccine against brucellosis, and the only preventive strategy is animal vaccination, which harbors significant disadvantages. Considering the identification of many immunogenic proteins in Brucella, several studies have recently been performed to evaluate the vaccine potency of such antigens as a new subunit vaccine candidate...
August 2, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28737147/brucella-causing-liver-abscess-in-a-child-with-selective-iga-deficiency
#4
Devdeep Mukherjee, Priyankar Pal, Ritabrata Kundu
BACKGROUND: Brucella has been known to cause pyrexia of unknown origin. CASE CHARACTERISTICS: 9-year-old boy with fever and abdominal pain; multiple abscesses within the liver on ultrasonography. OBSERVATIONS: IgM Antibodies against Brucella were raised in his serum sample, and Brucella serum agglutination test was positive. Immunological work-up suggested selective IgA deficiency. Reduction in size following treatment with trimethoprim-sulphamethoxazole, amikacin and doxycycline...
July 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28705257/single-stage-transforaminal-decompression-debridement-interbody-fusion-and-posterior-instrumentation-for-lumbosacral-brucellosis
#5
Yakefu Abulizi, Wei-Dong Liang, Aikeremujiang Muheremu, Maierdan Maimaiti, Wei-Bin Sheng
BACKGROUND: Spinal brucellosis is a less commonly reported infectious spinal pathology. There are few reports regarding the surgical treatment of spinal brucellosis in existing literature. This retrospective study was conducted to determine the effectiveness of single-stage transforaminal decompression, debridement, interbody fusion, and posterior instrumentation for lumbosacral spinal brucellosis. METHODS: From February 2012 to April 2015, 32 consecutive patients (19 males and 13 females, mean age 53...
July 14, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28702153/neurobrucellosis-in-systemic-lupus-erythematosus
#6
Jamshid Vafaeimanesh, Alireza Shahamzeh, Mohammad Bagherzadeh
BACKGROUND: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. CASE PRESENTATION: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hospital of Qom due to vertigo, drop attack and a convulsion episode from the previous day...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28699872/in-vitro-synergistic-effects-of-a-short-cationic-peptide-and-clinically-used-antibiotics-against-drug-resistant-isolates-of-brucella-melitensis
#7
Zohreh Mohammadi Azad, Hoda Moravej, Mahdi Fasihi-Ramandi, Faramarz Masjedian, Raziyeh Nazari, Reza Mirnejad, Mehrdad Moosazadeh Moghaddam
PURPOSE: In the last few decades, increasing microbial resistance to common antibiotics has attracted researchers' attention to the development of new classes of antibiotics such as antimicrobial peptides. Accordingly, the aim of the current study was to evaluate antimicrobial effects of the CM11 peptide alone and combined with common antibiotics against drug-resistant isolates of Brucella melitensis. METHODOLOGY: A total of 50 pathogenic samples of B. melitensis were isolated from patients and their antibiotic susceptibility pattern was evaluated by E-test...
July 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28693438/evaluation-of-recombinant-porin-romp2a-protein-as-a-potential-antigen-candidate-for-serodiagnosis-of-human-brucellosis
#8
Prachi Pathak, Ashu Kumar, Duraipandian Thavaselvam
BACKGROUND: Brucellosis is an important zoonotic disease caused by different Brucella species and human brucellosis is commonly prevalent in different states of India. Among various Brucella species, B. melitensis is most pathogenic to human and included as category B biothreat which can cause infection through aerosol, cut, wounds in skin and contact with infected animals. The diagnosis of human brucellosis is very important for proper treatment and management of disease as there is no vaccine available for human use...
July 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28689480/prevalence-and-risk-factors-of-brucellosis-among-veterinary-health-care-professionals
#9
Rajeswari Shome, Triveni Kalleshamurthy, Padmashree B Shankaranarayana, Prashanth Giribattanvar, Nagarathna Chandrashekar, Nagalingam Mohandoss, Bibek Ranjan Shome, Ashok Kumar, Sukhadeo B Barbuddhe, Habibur Rahman
The study describes prevalence, clinical symptoms and risk factors for brucellosis in personnel engaged in veterinary health care in Karnataka, India. A total of 1050 sera samples were collected from animal handlers, veterinarians, veterinary students, para-veterinarians and persons engaged in artificial insemination of animals. The sera samples were tested for brucellosis by Rose Bengal plate test (RBPT), serum agglutination test (SAT), IgG and IgM indirect ELISA and PCR. Age, sex, clinical symptoms and risk factors were recorded in structured questionnaire...
July 8, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28659924/brucella-dysregulates-monocytes-and-inhibits-macrophage-polarization-through-lc3-dependent-autophagy
#10
Yang Wang, Yuxiang Li, Haijun Li, Hongxiao Song, Naicui Zhai, Lixin Lou, Feng Wang, Kaiyu Zhang, Wanguo Bao, Xia Jin, Lishan Su, Zhengkun Tu
Brucellosis is caused by infection with Brucella species and exhibits diverse clinical manifestations in infected humans. Monocytes and macrophages are not only the first line of defense against Brucella infection but also a main reservoir for Brucella. In the present study, we examined the effects of Brucella infection on human peripheral monocytes and monocyte-derived polarized macrophages. We showed that Brucella infection led to an increase in the proportion of CD14(++)CD16(-) monocytes and the expression of the autophagy-related protein LC3B, and the effects of Brucella-induced monocytes are inhibited after 6 weeks of antibiotic treatment...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28623676/unrecognized-pediatric-and-adult-family-members-of-children-with-acute-brucellosis
#11
Dilek Yılmaz Çiftdoğan, Selda Aslan
BACKGROUND AND AIM: Brucellosis is an infectious, contagious and zoonotic disease that occurs worldwide. The family members of an index case of brucellosis may be especially susceptible, due to sharing the same source of infection and similar risk factors for brucellosis. In this study, we propose to screen pediatric and adult family members of brucellosis index cases for detecting additional unrecognized infected family members. MATERIALS AND METHODS: 114 family members of 41 pediatric patients with brucellosis were evaluated...
June 14, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28584176/one-health-contributions-towards-more-effective-and-equitable-approaches-to-health-in-low-and-middle-income-countries
#12
REVIEW
S Cleaveland, J Sharp, B Abela-Ridder, K J Allan, J Buza, J A Crump, A Davis, V J Del Rio Vilas, W A de Glanville, R R Kazwala, T Kibona, F J Lankester, A Lugelo, B T Mmbaga, M P Rubach, E S Swai, L Waldman, D T Haydon, K Hampson, J E B Halliday
Emerging zoonoses with pandemic potential are a stated priority for the global health security agenda, but endemic zoonoses also have a major societal impact in low-resource settings. Although many endemic zoonoses can be treated, timely diagnosis and appropriate clinical management of human cases is often challenging. Preventive 'One Health' interventions, e.g. interventions in animal populations that generate human health benefits, may provide a useful approach to overcoming some of these challenges. Effective strategies, such as animal vaccination, already exist for the prevention, control and elimination of many endemic zoonoses, including rabies, and several livestock zoonoses (e...
July 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28576116/endovascular-treatment-of-thoracic-aortic-pseudoaneurysm-due-to-brucellosis-a-rare-case-report
#13
Shuai Wang, Qi Wang, Han Liu, Siqiao Sun, Xiwei Sun, Yang Zhang, Zhongying Wang, Zhihua Cheng
BACKGROUND: Arterial damage is a known complication of brucellosis, but the occurrence of a thoracic aortic pseudoaneurysm secondary to brucellosis has not been previously reported. CASE PRESENTATION: A 65-year-old Chinese man presented with a pseudoaneurysm in the descending segment of the thoracic aorta that caused symptoms of chest pain and intermittent fever. He was diagnosed with a thoracic aortic pseudoaneurysm secondary to brucellosis based on a positive brucella serology test (standard-tube agglutination test) and imaging examination (computed tomography angiography)...
June 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28532790/a-safe-and-molecular-tagged-brucella-canis-ghosts-confers-protection-against-virulent-challenge-in-mice
#14
Jing Qian, Zhaoyang Bu, Xulong Lang, Guangmou Yan, Yanling Yang, Xiuran Wang, Xinglong Wang
Canine brucellosis, caused by Brucella canis, is a persistent infectious reproductive disease in dogs. The absence of effective treatment to the intracellular pathogen and the irreversible consequence of infection makes the need of a specific vaccine urgent. Bacterial ghosts (BGs) are the empty envelopes of bacteria with no genome content inside, which emerge as a proper vaccine candidate due to its intact outer antigen. It is generally derived from a genetically engineered strain, through the expression of Bacteriophage phiX174 lysis E gene upon induction...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28473914/isolated-splenic-abscess-in-brucellosis
#15
Sreenivasa Rao Sudulagunta, Monica Kumbhat, Mahesh Babu Sodalagunta, Aravinda Settikere Nataraju, Shiva Kumar Bangalore Raja
Brucellosis is a zoonotic infectious disease, which can attack any organ of the body but mainly involves lymphoreticular system. Our case report describes isolated splenic abscess diagnosed in a 50-year-old individual who is a milk vendor by occupation and has the habit of consuming raw milk. He was admitted with pain abdomen, high-grade fever with chills, generalized malaise, night sweats and weight loss. Ultrasound and computerized tomography of the abdomen showed splenomegaly and hypodense, nonenhancing lesion measuring 3...
February 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28459811/the-clinical-features-of-590-patients-with-brucellosis-in-xinjiang-china-with-the-emphasis-on-the-treatment-of-complications
#16
Bin Jia, Fengbo Zhang, Ying Lu, Wenbao Zhang, Jun Li, Yuexin Zhang, Jianbing Ding
BACKGROUND: This study aims to analyze the clinical characteristics and treatment outcomes of 590 patients with brucellosis in Xinjiang, China. METHODOLOGY AND PRINCIPAL FINDINGS: The clinical characteristics, laboratory findings, complications and prognosis of 590 patients infected with brucellosis were retrospectively analyzed. These patients had a mean age of 44.24 ± 15.83 years with 60.5% having a history of close contacting with cattle and sheep. Of them, 53...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28411163/development-of-a-multi-epitope-peptide-vaccine-inducing-robust-t-cell-responses-against-brucellosis-using-immunoinformatics-based-approaches
#17
Mahdiye Saadi, Ahmad Karkhah, Hamid Reza Nouri
Current investigations have demonstrated that a multi-epitope peptide vaccine targeting multiple antigens could be considered as an ideal approach for prevention and treatment of brucellosis. According to the latest findings, the most effective immunogenic antigens of brucella to induce immune responses are included Omp31, BP26, BLS, DnaK and L7-L12. Therefore, in the present study, an in silico approach was used to design a novel multi-epitope vaccine to elicit a desirable immune response against brucellosis...
April 11, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28388625/poor-performance-of-the-rapid-test-for-human-brucellosis-in-health-facilities-in-kenya
#18
William A de Glanville, Raquel Conde-Álvarez, Ignacio Moriyón, John Njeru, Ramón Díaz, Elizabeth A J Cook, Matilda Morin, Barend M de C Bronsvoort, Lian F Thomas, Samuel Kariuki, Eric M Fèvre
Human brucellosis is considered to be an important but typically under-diagnosed cause of febrile illness in many low and middle-income countries. In Kenya, and throughout East Africa, laboratory diagnosis for the disease is based primarily on the febrile antigen Brucella agglutination test (FBAT), yet few studies of the diagnostic accuracy of this test exist. Assessment of the performance of the FBAT is essential for its appropriate clinical use, as well as for evaluating surveillance data reported by public health systems...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28348782/an-unusual-case-of-seronegative-16s-pcr-positive-brucella-infection
#19
Binutha Bharathan, Lucy Backhouse, David Rawat, Sandhia Naik, Michael Millar
INTRODUCTION: Brucella is a zoonotic infection commonly diagnosed by isolation of the organism from blood culture or positive serological testing. It is an uncommon cause of a pyrexia of unknown origin in the United Kingdom. CASE PRESENTATION: We describe the case of a 14-year-old girl with no history of travel who presented with pyrexia, weight loss, arthralgia, multiple splenic abscesses and a subsequent pleural effusion, the latter of which isolated a Brucella species on 16S rRNA PCR...
October 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28337351/a-rare-form-of-brucella-bursitis-with-negative-serology-a-case-report-and-literature-review
#20
F M Almajid
Brucellosis is still endemic in certain parts of the world including the Mediterranean, the Middle East, Latin America, and African regions. Osteoarticular manifestations are common presenting features. Brucellosis presenting as prepatellar bursitis has already been reported. We present a case of seronegative olecranon bursitis with positive blood and aspirate cultures. The patient improved remarkably by treatment with streptomycin and doxycycline with no evidence or relapse.
2017: Case Reports in Infectious Diseases
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