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https://www.readbyqxmd.com/read/29125076/-a-14-year-old-syrian-refugee-with-neurobrucellosis
#1
M S W Quaak, H H J Bavelaar, J Berkhout, G J Tuin, E M Bijker
BACKGROUND: Neurobrucellosis is a rare complication of brucellosis, a bacterial zoonotic disease endemic in regions such as the Middle East. It is important to be alert for this imported disease in the Netherlands as well, especially among migrants. CASE DESCRIPTION: A 14-year-old boy from Syria presented with headache, vomiting and weight loss. Brucella melitensis was identified in the cerebrospinal fluid. The patient's condition deteriorated despite antibiotic treatment, particularly neurologically, and imaging revealed a newly developed hydrocephalus...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29113778/quantitative-polymerase-chain-reaction-based-quantification-of-brucella-dna-in-serum-of-pre-and-post-therapeutic-occupationally-exposed-infected-human-population
#2
S Thakur, J S Bedi, R Singh, J P S Gill, A K Arora, Neeraj Kashyap
BACKGROUND: Brucellosis is one of the neglected zoonotic diseases in humans. The serological methods based on antibody detections are unable to detect the effectiveness of treatment in humans as antibodies persist for long time in humans even after therapy. Therefore, we developed qPCR technique to overcome such discrepancy and device a rapid and efficient test for both diagnosis and follow up of the brucellosis affected individuals. METHODS: High risk suspected individuals with positive serology (RBPT, STAT and iELISA) and PCR were mainly analyzed for DNA quantification by qPCR assay...
November 4, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29036953/-a-clinical-analysis-of-six-patients-with-brucella-endocarditis-and-literature-review
#3
L Luo, B T Zhou, H L Wang, H T Dou, T S Li
Objective: To analyze the epidemiology and clinical characteristics of patients with Brucella endocarditis in order to improve the understanding and treatment of Brucella endocarditis. Methods: The clinical data including demographic characteristics, clinical features, laboratory data, echocardiography, treatment and clinical outcome of 6 patients with Brucella endocarditis were collected and analyzed. Results: In our database consisting of 211 brucellosis patients with positive blood culture, 6 patients (2...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036949/-paying-more-attentions-to-diagnosis-and-treatment-of-complex-brucellosis
#4
W H Zhang
No abstract text is available yet for this article.
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29031243/preparation-and-evaluation-of-rifampicin-and-co-trimoxazole-loaded-nanocarrier-against-brucella-melitensis-infection
#5
Narges Bodaghabadi, Samira Hajigholami, Ziba Vaise Malekshahi, Maliheh Entezari, Farhood Najafi, Hadi Shirzad, Majid Sadeghizadeh
Background: Brucellosis or Malta fever is a contagious infection common between human and domestic animals. Many antibiotics are used for brucellosis treatment, but they are not efficient and put heavy burden on society. Co-trimoxazole and rifampicin are two candidates for brucellosis treatment. In this study, we aimed to enhance the efficacy of these antibiotics using designed nanoparticles. Methods: Different concentrations of co-trimoxazole and rifampicin were used for loading onto a nanostructure of synthesized monomethoxy poly(ethylene glycol)-oleate (mPEG-OA)...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28991320/-brucellosis-in-chile-description-of-a-series-of-13-cases
#6
Roberto Olivares, Pamela Vidal, Camila Sotomayor, Mackarenna Norambuena, Mario Luppi, Francisco Silva, Marcela Cifuentes
INTRODUCTION: Brucellosis is a zoonosis caused by Brucella spp. It may be acquired by consuming unpasteurized dairy products. Brucellosis has a low incidence in Chile, thus, we have a scarce data. AIM: To report and to characterize the first series of clinical cases of adult patients diagnosed with brucellosis in Chile. METHODS: We describe a series of 13 clinical cases in patients diagnosed between 2000 and 2016 in three different centers in the Metropolitan Region, Chile...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28954065/guidelines-for-the-management-of-human-brucellosis-in-the-state-of-paran%C3%A3-brazil
#7
Felipe Francisco Tuon, Natacha Cerchiari, Juliana Clélia Cequinel, Elizabeth El Hajjar Droppa, Suzana Dal Ri Moreira, Tânia Portella Costa, Amanda de Paula Boni Navarro, Antonieta Milleo Handar, Margely Nunes de Souza
Human brucellosis is a re-emerging disease with the potential for bioterrorism. The number of cases in Brazil has increased; however, the ideal management has not been established. These guidelines are intended for use by clinicians and other health-care workers providing medical care for patients with suspected brucellosis in the State of Paraná. We included a brief description of the epidemiology, clinical presentation, diagnosis, prevention of exposure, prevention of disease by chemoprophylaxis, treatment of disease, monitoring of adverse effects during treatment, management of treatment failure and relapse cases...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28942834/brucellosis-a-lymphoma-like-presentation
#8
Marcel Massoud, Fouad Kerbage, Leony Antoun, Ribal Merhi, Souheil Hallit, Rabih Hallit
Brucellosis is one of the most common zoonotic infections worldwide caused by gram negative bacilli of the genus Brucella. It is transmitted to humans by contact with infected animals or derived food products such as unpasteurized milk. Brucellosis' clinical presentation varies widely from multi-systemic involvement to asymptomatic infection. We present the case of a 52-year-old Lebanese male who was admitted to our hospital with a 3-week history of fever (up to 40 °C), chills, night sweats and abdominal pain...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28929962/-determination-of-in-vitro-susceptibilities-of-brucella-spp-strains-against-11-different-antibacterial-gents-isolated-from-blood-cultures
#9
Recep Keşli, Hüseyin Bilgin, Halim Yılmaz
Brucellosis is a worldwide zoonotic disease and still continuous to be a major public health problem. In this study, it was aimed to identify the Brucella strains to the species level isolated from blood cultures, and to determine the rate of antimicrobial susceptibility against eleven antibacterial agents. A total of 106 Brucella spp. strains were included in the study, which were isolated from blood cultures in University of Health Sciences, Konya Training and Research Hospital, Medical Microbiology Laboratory between January 2011 and June 2013...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28926008/the-economic-efficiency-and-equity-of-government-policies-on-brucellosis-comparative-insights-from-albania-and-the-united-states-of-america
#10
D Peck, M Bruce
Brucellosis is a zoonotic bacterial disease that causes recurring febrile illness in humans, as well as reproductive failure and reduced milk production in livestock. The cost of brucellosis is equal to the sum of lost productivity of humans and animals, as well as private and public expenditures on brucellosis surveillance, prevention, control and treatment. In Albania, Brucella abortus and B. melitensis affect humans, cattle and small ruminants. In the United States, B. abortus affects cattle and wild ungulates in the Greater Yellowstone Area...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28924723/sixteen-chinese-pediatric-brucellosis-patients-onset-of-fever-in-non-epidemic-areas-and-8-developed-with-osteoarticular-involvement
#11
Xinning Wang, Yuchun Yan, Fengqi Wu, Gaixiu Su, Shengnan Li, Xinyu Yuan, Jianming Lai, Zhixuan Zhou
The purpose of this study is to summarize the manifestations, diagnosis, differential diagnosis, and treatment of childhood brucellosis in non-epidemic areas of China. A retrospective review of 16 admitted children patients with brucella's disease who were diagnosed of brucellosis during the period from 2011 to 2016 was performed. Diagnostic criteria, clinical presentations, and outcomes were recorded. The most common symptom was fever. Osteoarticular involvement was found in 50% of the patients. They were infected by contacting with infected animals or consuming of unpasteurized milk or meat of sheep or goats, also...
September 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#12
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28826825/effect-of-hydroxychloroquine-on-treatment-and-recurrence-of-acute-brucellosis-a-single-blind-randomized-clinical-trial
#13
Mohammad Mahdi Majzoobi, Seyyed Hamid Hashemi, Mojgan Mamani, Fariba Keramat, Jalal Poorolajal, Hamid Reza Ghasemi Basir
Nowadays, one of the major problems of brucellosis is its high recurrence rate and using more than one course of standard treatment regimens. Therefore, more researches need to find more effective treatments which lead to prompt recovery and reduce the relapse of disease. This single-blind randomized study was designed to evaluate the effect of the standard treatment of brucellosis in combination with hydroxychloroquine. Totally, 177 patients with acute brucellosis were randomly assigned to one of two treatment groups including doxycycline-streptomycin (DS) and doxycycline-streptomycin-hydroxychloroquine (DSH)...
August 4, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28812192/safety-of-vaccination-against-brucellosis-with-the-rough-strain-in-pregnant-cattle
#14
Adriana Agostini Barbosa, Ana Cristina Silva Figueiredo, Miller Pereira Palhao, Joao Henrique Moreira Viana, Carlos Antonio Carvalho Fernandes
Brucellosis is an infectious and contagious disease that profoundly impacts public health. However, in many countries, disease prevention is restricted to the vaccination of calves, and there is no prophylactic strategy for pregnant heifers and cows. The aim of this study was to evaluate the safety of the rough strain vaccine against brucellosis in pregnant cattle. Crossbred cows (N = 96) at three gestational periods (early, mid, or late pregnancy) were randomly allocated into the vaccine treatment group or to the control group...
August 15, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28768443/neurobrucellosis
#15
Na Zheng, Wei Wang, Jia-Tang Zhang, Ya Cao, Long Shao, Jiao-Jiao Jiang, Xu-Sheng Huang, Cheng-Lin Tian, Sheng-Yuan Yu
Neurobrucellosis (NB) is a rare complication of brucellosis. NB presents with a variety of clinical manifestations, and the symptoms are always atypical. Our aim was to analyze the demographic characteristics, clinical manifestations, laboratory findings, imaging findings, treatments and outcomes of patients with NB. We retrospectively reviewed the data from 17 patients with NB hospitalized at the Chinese People's Liberation Army General Hospital between January 1, 2005 and October 31, 2016. The following symptoms were recorded: 10/17 (59%) patients had fever, and 9/17 (53%) patients had a disorder affecting urination and defecation...
August 3, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28766326/a-review-of-brucellosis-in-iran-epidemiology-risk-factors-diagnosis-control-and-prevention
#16
Maryam Golshani, Saeid Buozari
Brucellosis caused by species of Brucella is among the most prevalent zoonoses with the annual incidence of half a million cases globally. Most parts of Iran are endemic for brucellosis, and the annual incidence of the human and animal brucellosis is still high. At present, there is no safe and protective human vaccine against brucellosis, and the only preventive strategy is animal vaccination, which harbors significant disadvantages. Considering the identification of many immunogenic proteins in Brucella, several studies have recently been performed to evaluate the vaccine potency of such antigens as a new subunit vaccine candidate...
August 2, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28737147/brucella-causing-liver-abscess-in-a-child-with-selective-iga-deficiency
#17
Devdeep Mukherjee, Priyankar Pal, Ritabrata Kundu
BACKGROUND: Brucella has been known to cause pyrexia of unknown origin. CASE CHARACTERISTICS: 9-year-old boy with fever and abdominal pain; multiple abscesses within the liver on ultrasonography. OBSERVATIONS: IgM Antibodies against Brucella were raised in his serum sample, and Brucella serum agglutination test was positive. Immunological work-up suggested selective IgA deficiency. Reduction in size following treatment with trimethoprim-sulphamethoxazole, amikacin and doxycycline...
July 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28705257/single-stage-transforaminal-decompression-debridement-interbody-fusion-and-posterior-instrumentation-for-lumbosacral-brucellosis
#18
Yakefu Abulizi, Wei-Dong Liang, Aikeremujiang Muheremu, Maierdan Maimaiti, Wei-Bin Sheng
BACKGROUND: Spinal brucellosis is a less commonly reported infectious spinal pathology. There are few reports regarding the surgical treatment of spinal brucellosis in existing literature. This retrospective study was conducted to determine the effectiveness of single-stage transforaminal decompression, debridement, interbody fusion, and posterior instrumentation for lumbosacral spinal brucellosis. METHODS: From February 2012 to April 2015, 32 consecutive patients (19 males and 13 females, mean age 53...
July 14, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28702153/neurobrucellosis-in-systemic-lupus-erythematosus
#19
Jamshid Vafaeimanesh, Alireza Shahamzeh, Mohammad Bagherzadeh
BACKGROUND: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. CASE PRESENTATION: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hospital of Qom due to vertigo, drop attack and a convulsion episode from the previous day...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28699872/in-vitro-synergistic-effects-of-a-short-cationic-peptide-and-clinically-used-antibiotics-against-drug-resistant-isolates-of-brucella-melitensis
#20
Zohreh Mohammadi Azad, Hoda Moravej, Mahdi Fasihi-Ramandi, Faramarz Masjedian, Raziyeh Nazari, Reza Mirnejad, Mehrdad Moosazadeh Moghaddam
PURPOSE: In the last few decades, increasing microbial resistance to common antibiotics has attracted researchers' attention to the development of new classes of antibiotics such as antimicrobial peptides. Accordingly, the aim of the current study was to evaluate antimicrobial effects of the CM11 peptide alone and combined with common antibiotics against drug-resistant isolates of Brucella melitensis. METHODOLOGY: A total of 50 pathogenic samples of B. melitensis were isolated from patients and their antibiotic susceptibility pattern was evaluated by E-test...
July 2017: Journal of Medical Microbiology
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