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https://www.readbyqxmd.com/read/28101501/classical-presentation-of-acute-pyelonephritis-in-a-case-of-brucellosis
#1
Wadha Alfouzan, Sara Al-Sahali, Hawra'a Sultan, Rita Dhar
Although Brucella species is known to affect almost all organs in humans, renal involvement presenting as acute pyelonephritis remains a rare entity in brucellosis. We report the case of a female patient who presented with symptoms of fever with chills, right loin pain and dysuria in the emergency room. Blood cultures drawn at the time of admission grew Brucella spp., but no organisms were isolated from urine culture although urinalysis data was indicative of urinary tract infection. Empiric therapy with piperacillin/tazobactam plus gentamicin relieved her symptoms...
May 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28081318/clinical-characteristics-and-outcome-of-brucella-endocarditis
#2
Na Du, Feng Wang
BACKGROUND/AIM: Brucella endocarditis, which is a rare condition, is the most common cause of death in human brucellosis, leading to severe cardiac complications. By collecting and analyzing clinical cases, we analyzed the clinical characteristics and outcome of Brucella endocarditis in endemic areas in China. MATERIALS AND METHODS: Presented here are 5 cases of Brucella endocarditis, all managed uniformly. We present the clinical, serological, and echocardiographic features; the therapeutic approach; and the follow-up of five patients with Brucella endocarditis...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079834/intestinal-brucellosis-associated-with-celiac-artery-and-superior-mesenteric-artery-stenosis-and-with-ileum-mucosa-and-submucosa-thickening-a-case-report
#3
Miaoqian Wang, Qingli Zhu, Qian Yang, Wenbo Li, Xinning Wang, Wei Liu, Baotong Zhou, Zhenghong Li, Hong Yang
RATIONALE: Brucellosis is a multisystem infection found worldwide that has a broad range of characteristics, which range from acute fever and hepatomegaly to chronic infections that most commonly affect the central nervous system, cardiovascular system, or skeletal system. Gastrointestinal and splanchnic artery involvements in brucellosis are relatively uncommon. PATIENT CONCERNS: We report a case of brucellosis in an adolescent presenting as intermittent abdominal pain, diarrhea, and fever, with intestinal tract involvement...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068278/cervical-spondylitis-and-epidural-abscess-caused-by-brucellosis-a-case-report-and-literature-review
#4
Hatice Reşorlu, Suzan Saçar, Beşir Şahin Inceer, Ayla Akbal, Ferhat Gökmen, Coskun Zateri, Yilmaz Savaş
Brucellosis is a zoonotic disease widely seen in endemic regions and that can lead to systemic involvement. The musculoskeletal system is frequently affected, and the disease can exhibit clinical involvements such as arthritis, spondylitis, spondylodiscitis, osteomyelitis, tenosynovitis and bursitis. Spondylitis and spondylodiscitis, common complications of brucellosis, predominantly affect the lumbar and thoracic vertebrae. Epidural abscess may occur as a rare complication of spondylitis. Spinal brucellosis and development of epidural abscess in the cervical region are rare...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28062553/neurobrucellosis-unexpected-answer-from-metagenomic-next-generation-sequencing
#5
Kanokporn Mongkolrattanothai, Samia N Naccache, Jeffrey M Bender, Erik Samayoa, Elizabeth Pham, Guixia Yu, Jennifer Dien Bard, Steve Miller, Grace Aldrovandi, Charles Y Chiu
A diagnosis of brucellosis can be difficult because routine culture and serological methods exhibit variable sensitivity and specificity. We present the use of a metagenomic next- generation sequencing assay to diagnose a case of neurobrucellosis from cerebrospinal fluid, resulting in the institution of appropriate antibiotic treatment and a favorable clinical outcome.
January 6, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28053932/neurobrucellosis-presented-with-a-hyperacute-onset-a-case-report
#6
Arefeh Khademi, Maryam Poursadeghfard, Reza Nikandish Noubar
Neurobrucellosis is uncommon; however, it is an important complication of brucellosis, which could be seen in any stage of the disease. It presents with different kinds of neurology manifestations and diagnosis is mainly made on history, physical examination and laboratory tests. The clinical course of the disease is relatively insidious and the most common pattern of presentation is subacute or chronic. It has a long-term treatment period and its response to treatment is slow. Here, we report a case of an apparent healthy 25 yr-old Afghani woman from Fars Province (south of Iran) that presented at first with hyperacute onset of headache and abnormal behavior and diagnosed neurobrucellosis in Nov 2015...
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28033700/brucellosis-with-multi-organ-involvement-in-a-patient-with-history-of-composite-aortic-graft-and-hepatitis-b
#7
Seyed Ali Dehghan Manshadi, Omid Rezahosseini, Zahra Abdi Liaei
The brucellosis with multi-organ involvement in a patient with a history of the composite aortic graft (Bentall procedure) and Hepatitis B infection is rare. A 35-year-old man presented to us with fever and loss of consciousness. Four years ago, he was IDU and underwent cardiac surgery because of endocarditis. Recently lumbar spondylodiscitis was diagnosed. The Wright (1/320) and Coombs Wright tests (1/640) were positive. After CNS imaging, lumbar puncture was done. The CSF pleocytosis was lymphocyte dominant...
November 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28017899/nocodazole-treatment-interrupted-brucella-abortus-invasion-in-raw-264-7-cells-and-successfully-attenuated-splenic-proliferation-with-enhanced-inflammatory-response-in-mice
#8
Alisha Wehdnesday Bernardo Reyes, Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Wongi Min, Hu Jang Lee, Hong Hee Chang, Suk Kim
Brucellosis is one of the most important and widespread zoonosis worldwide responsible for serious economic losses and considerable public health burden. In this study, we investigated the modulatory effect of a microtubule-inhibitor, nocodazole, on B. abortus infection in murine macrophages and in a mouse model. Nocodazole activated macrophages and directly inhibited the growth of Brucella in a dose-dependent manner. Nocodazole increased adhesion but reduced invasion and intracellular growth of Brucella in macrophages although it did not affect co-localization of Brucella with LAMP-1...
December 23, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28012988/the-host-immune-enhancing-agent-korean-red-ginseng-oil-successfully-attenuates-brucella-abortus-infection-in-a-murine-model
#9
Alisha Wehdnesday Bernardo Reyes, Huynh Tan Hop, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Soo Jong Park, Kwang Dong Kim, WonGi Min, Hu Jang Lee, Man Hee Rhee, Yi-Seong Kwak, Suk Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng Meyer (Araliaceae), is one of the most valuable traditional Chinese medicines and is used for the treatment of various human diseases. In this study, we elucidated the protective mechanism of the essential oil from Korean red ginseng (RGO) against Brucella infection. MATERIALS AND METHODS: The effects of RGO on Brucella abortus viability, NO production, uptake and intracellular growth in macrophages were investigated...
December 21, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27994212/intracellular-trafficking-modulation-by-ginsenoside-rg3-inhibits-brucella-abortus-uptake-and-intracellular-survival-within-raw-264-7-cells
#10
Tran Xuan Ngoc Huy, Alisha Wehdnesday Bernardo Reyes, Huynh Tan Hop, Lauren Togonon Arayan, WonGi Min, Hu Jang Lee, Man Hee Rhee, Hong Hee Chang, Suk Kim
Ginsenoside Rg3, a saponin extracted from Ginseng, has various pharmacological and biological activities, however its effects against Brucella infection are still unclear. Herein, the inhibitory effects of ginsenoside Rg3 against intracellular parasitic Brucella infection were evaluated through bacterial infection, adherence assays, and LAMP-1 colocalization, as well as immunoblotting and FACS for detecting MAPKs signaling proteins and F-actin polymerization, respectively. The internalization, intracellular growth and adherence of Brucella (B...
December 20, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27993134/epidemic-characteristics-high-risk-townships-and-space-time-clusters-of-human-brucellosis-in-shanxi-province-of-china-2005-2014
#11
Qiulan Chen, Shengjie Lai, Wenwu Yin, Hang Zhou, Yu Li, Di Mu, Zhongjie Li, Hongjie Yu, Weizhong Yang
BACKGROUND: Brucellosis, one of the world's most important zoonosis, has been re-emerging in China. Shanxi Province, located in northern China, where husbandry development has been accelerated in recent years, has a rather high incidence of human brucellosis but drew little attention from the researchers. This study aimed to describe the changing epidemiology of human brucellosis in Shanxi Province from 2005 to 2014 and explore high-risk towns and space-time clusters for elucidating the necessity of decentralizing disease control resource to township level in epidemic regions, particularly in hotspot areas...
December 19, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27966338/the-clinical-and-laboratory-characteristics-treatments-and-outcomes-of-patients-with-brucella-epididymo-orchitis-beo-compared-to-those-without-beo
#12
Hasan Naz, Pınar Korkmaz, Figen Çevik, Nevil Aykın
BACKGROUND/AIM: We aim to describe the clinical and laboratory characteristics, treatment, and outcomes of 21 patients with Brucella epididymo-orchitis (BEO) from Eskişehir Yunus Emre State Hospital, Turkey. MATERIALS AND METHODS: A total of 21 patients with BEO who were diagnosed and followed in the Infectious Diseases Clinic between June 2001 and June 2013 were evaluated retrospectively. RESULTS: One hundred and twenty-eight of 192 patients evaluated throughout the study were male and BEO was determined in 21 (16...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27966296/interlukine-17-and-tgf-%C3%AE-levels-in-patients-with-acute-brucellosisbefore-and-after-treatment
#13
Masoomeh Sofian, Amitis Ramezani, Alia Mousavi, Mohammad Banifazl, Shima Cherei, Ali Cherei, Arezoo Aghakhani
BACKGROUND/AIM: T-helper cell type 1 (Th1)/Th2 cytokine balance is involved in the resistance or susceptibility to Brucella infection. The analysis of cytokine levels is valuable to determine the role of the immune system in Brucella prognosis. The aim of this study was to investigate the levels of serum interleukin-17 (IL-17) and transforming growth factor beta (TGF-β) and their alterations with treatment in patients with acute brucellosis. MATERIALS AND METHODS: TGF-β was tested in 33 acute brucellosis patients and 19 controls and IL-17 was analyzed in 40 patients and 12 controls...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27928078/polymerase-chain-reaction-based-assays-for-the-diagnosis-of-active-and-relapsed-cases-of-human-brucellosis
#14
Mohammad Reza Hasanjani Roushan, Seyed Mahmoud Amin Marashi, Zahra Moulana
This study aimed to compare polymerase chain reaction (PCR) with serum agglutination test (SAT) in the diagnosis of patients before and 6 months after treatment. Peripheral blood specimens from 50 patients with brucellosis (case group) and 30 subjects without brucellosis (control group) were selected and entered into the study. The diagnosis of brucellosis was established using SAT ≥ 1:160 and 2-mercaptoethanol (2-ME) ≥ 1:80 with clinical signs and symptoms compatible with brucellosis. For each case, both before treatment and 6 months after completion of therapy, SAT, 2-ME, and PCR were performed...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27790937/treatment-of-pulmonary-brucellosis-a-systematic-review
#15
Javier Solera, Julián Solís García Del Pozo
Pulmonary involvement is a rare, focal complication of human brucellosis. The aim of this review is to describe clinical and radiologic features, treatment administered and clinical course of these patients. Areas covered: We conducted a systematic search of scientific reports of brucellosis with pulmonary involvement published from January 1985 to July 2016. Four main patterns of disease were observed: pneumonia, pleural effusion, nodules and interstitial pattern. Cough and fever were the most common symptoms...
January 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27769947/chemical-composition-antibacterial-activity-and-related-mechanism-of-the-essential-oil-from-the-leaves-of-juniperus-rigida-sieb-et-zucc-against-klebsiella-pneumoniae
#16
Xiaxia Meng, Dengwu Li, Dan Zhou, Dongmei Wang, Qiaoxiao Liu, Sufang Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Juniperus rigida is used as Tibetan and Mongolian medicine in China for the treatment of rheumatoid arthritis, nephritis, brucellosis and other various inflammatory diseases. AIM OF THE STUDY: To evaluate antibacterial potential of essential oils from J. rigida leaves against Klebsiella pneumoniae and to examine its possible related mechanisms. The study was undertaken in order to scientifically validate the traditional use of J. rigida...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27761286/brucella-infection-associated-with-complete-atrioventricular-block
#17
Meki Bilici, Fikri Demir, Murat Muhtar Yılmazer, Fatma Bozkurt, Volkan Tuzcu
BACKGROUND: The clinical spectrum of Brucella infection is quite diverse and characterized by multi-system involvement. Patients present with myocarditis, endocarditis, or pericarditis. Infective endocarditis is the most common cardiovascular complication in patients with brucellosis. Although conduction abnormalities are seen in cases with endocarditis, they are reported very rarely in the setting of cardiac Brucella infection. CASE REPORT: An eight and a half-year-old male patient was referred to our clinic due to inadequate response to cotrimaxazole plus streptomycin treatment at the 15th day of admission...
September 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27733806/socio-demographic-study-on-extent-of-knowledge-awareness-attitude-and-risks-of-zoonotic-diseases-among-livestock-owners-in-puducherry-region
#18
K Rajkumar, A Bhattacharya, S David, S Hari Balaji, R Hariharan, M Jayakumar, N Balaji
AIM: This study was conducted to assess the extent of knowledge, awareness, attitude, and risks of zoonotic diseases among livestock owners in Puducherry region. MATERIALS AND METHODS: A total of 250 livestock farmers were selected randomly from eight revenue villages. And each farmer was interviewed with a questionnaire containing both open- and close-ended questions on various aspects of zoonotic diseases, a total of 49 questionnaires were framed to assess the source and transmission of infection to the farmers and to test their knowledge and awareness about zoonotic diseases...
September 2016: Veterinary World
https://www.readbyqxmd.com/read/27722176/altered-expressions-of-mir-1238-3p-mir-494-mir-6069-and-mir-139-3p-in-the-formation-of-chronic-brucellosis
#19
Ferah Budak, Salih Haldun Bal, Gulcin Tezcan, Halis Akalın, Guher Goral, Haluk Barbaros Oral
Brucellosis is a zoonotic disease that is still endemic in developing countries. Despite early diagnosis and treatment of patients, chronic infections are seen in 10-30% of patients. In this study, we aimed to investigate the immunological factors that play roles in the transition of brucellosis from acute infection into chronic infection. Here, more than 2000 miRNAs were screened in peripheral blood mononuclear cells (PBMCs) of patients with acute or chronic brucellosis and healthy controls by using miRNA array, and the results of the miRNA array were validated through qRT-PCR...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27703129/overview-of-brucellosis-in-nepal
#20
Krishna Prasad Acharya, Nirajan Niroula, Krishna Kaphle
Brucellosis is an abortifacient zoonotic disease which remains prominent in third world countries like Nepal. Brucellosis possess a public health concern, the incidences of which in livestocks can present substantial economic and health burdens for herders and health professionals. In Nepal, several cases of bovine including human brucellosis have been reported. This paper aims to evaluate the current status of the disease, the mechanism of infection, pathogenesis, zoonotic potential, diagnostic advances, treatment regimens, and the preventive measures that can be adopted in managing human brucellosis in under-developed countries like Nepal...
October 1, 2016: Epidemiology and Health
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