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https://www.readbyqxmd.com/read/28937845/pharmacokinetics-of-beclomethasone-dipropionate-delivered-by-breath-actuated-inhaler-and-metered-dose-inhaler-in-healthy-subjects
#1
Calvin J Small, Michael Gillespie
BACKGROUND: Breath-actuated inhalers (BAIs) eliminate the need for hand-breath coordination required of pressurized metered-dose inhalers (MDIs). This pharmacokinetic study compared systemic exposure following beclomethasone dipropionate delivery through BAI versus MDI. METHODS: This open-label, three-period crossover, single-dose study randomized healthy subjects aged 18-45 years (N = 72) to 1 of 6 treatment sequences containing beclomethasone dipropionate BAI 160 mcg (40 mcg/inhalation, 4 inhalations), beclomethasone dipropionate BAI 320 mcg (80 mcg/inhalation, 4 inhalations), and beclomethasone dipropionate MDI 320 mcg (80 mcg/inhalation, 4 inhalations)...
September 22, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28937270/feasibility-of-free-breathing-lung-mri-for-radiotherapy-using-non-cartesian-k-space-acquisition-schemes
#2
Shivani Kumar, Robba Rai, Alto Stemmer, Sonal Josan, Lois Holloway, Shalini Vinod, Daniel Moses, Gary Liney
OBJECTIVES: To test a free breathing MRI protocol for anatomical and functional assessment during lung cancer radiotherapy by assessing two non-cartesian acquisition schemes based on a T1W 3D gradient recall echo sequence: (i) stack-of stars (StarVIBE) and (ii) spiral (SpiralVIBE) trajectories Methods: MR images on five healthy volunteers were acquired on a wide bore 3T scanner (Skyra, Siemens Healthcare). Anatomical image quality was assessed on: (1) free breathing (StarVIBE), (2) the standard clinical sequence (VIBE) acquired in a 20 second compliant breath-hold and (3) 20 second non-complaint breath-hold...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937266/statistical-analysis-of-adcs-and-clinical-biomarkers-in-detecting-acute-renal-transplant-rejection
#3
Elizabeth Hollis, Mohamed Shehata, Mohamed Abou El-Ghar, Mohammed Ghazal, Tarek Eldiasty, Michael Merchant, Andrew E Switala, Ayman El-Baz
OBJECTIVE: To determine which parameters are correlated with transplanted kidney status in patients who have undergone kidney transplantation and can be used for early assessment of acute renal rejection. METHODS: The study included 16 patients with stable renal allografts (Group 1) and 37 patients with rejected allografts (Group 2), determined by renal biopsy post transplantation. All patients' kidneys were evaluated using diffusion-weighted MRI (DW-MRI), in which both clincal and MRI-derived biomarkers were integrated...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937021/optimized-high-dose-amoxicillin-proton-pump-inhibitor-dual-therapies-fail-to-achieve-high-cure-rates-in-china
#4
Jia-Li Hu, Jun Yang, Yin-Bin Zhou, Ping Li, Ran Han, Dian-Chun Fang
Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylori infection. Rabeprazole dosages for H. pylori eradication were also evaluated. PATIENTS AND METHODS: Treatment-naive and H...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28936952/-application-of-injection-test-in-confirming-the-ideal-position-of-esophageal-balloon-catheter
#5
Han Chen, Ming Xu, Yanlin Yang, Xuan He, Jianxin Zhou
OBJECTIVE: To evaluate the safety and feasibility of injection test which is used to locate esophageal balloon catheter. METHODS: A prospective study was conducted. The patients undergoing invasive mechanical ventilation (MV) admitted to general intensive care unit (ICU) of Beijing Tiantan Hospital Affiliated to Capital Medical University from May 2015 and March 2017 were enrolled. The commercially available esophageal balloon catheter was modified to perform injection test...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28934528/the-impact-of-altitude-on-sleep-disordered-breathing-in-children-dwelling-at-high-altitude-a-crossover-study
#6
Benjamin H Hughes, John T Brinton, David G Ingram, Ann C Halbower
Study Objectives: Sleep-disordered breathing (SDB) is prevalent among children and is associated with adverse health outcomes. Worldwide, approximately 250 million individuals reside at altitudes higher than 2000 meters above sea level (masl). The effect of chronic high-altitude exposure on children with SDB is unknown. This study aims to determine the impact of altitude on sleep study outcomes in children with SDB dwelling at high altitude. Methods: A single-center crossover study was performed to compare results of high-altitude home polysomnography (H-PSG) with lower altitude laboratory polysomnography (L-PSG) in school-age children dwelling at high altitude with symptoms consistent with SDB...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28933338/impact-of-lubiprostone-on-gastric-emptying-profile-and-the-possible-effect-of-concomitant-domperidone-in-healthy-adults%C3%A2
#7
Takayuki Okamura, Takatsugu Yamamoto, Satoshi Kimura, Atsushi Miki, Koichiro Abe, Hiroto Kita
BACKGROUND: Lubiprostone is effective for patients with chronic constipation. This agent sometimes causes upper gastrointestinal symptoms, such as nausea, which is one of the chief reasons for discontinuation. However, the etiology of and strategy against bothersome gastrointestinal symptoms of lubiprostone remain unclear. AIMS: The goal of this study was to investigate the influence of lubiprostone on the gastric-emptying profile of healthy adults. The effect of domperidone on gastric emptying and gastrointestinal symptoms after lubiprostone administration were also assessed...
September 21, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28932087/modified-helicobacter-test-using-a-new-test-meal-and-a-13-c-urea-breath-test-in-helicobacter-pylori-positive-and-negative-dyspepsia-patients-on-proton-pump-inhibitors
#8
Bojan Tepeš, Peter Malfertheiner, Joachim Labenz, Sitke Aygen
AIM: To determine the sensitivity and specificity of the (13)C-urea breath test (UBT) in patients taking proton pump inhibitors (PPIs), using a new test meal Refex. METHODS: One hundred and fourteen consecutive patients with dyspepsia, 53 Helicobacter pylori (H. pylori) positive, 49 H. pylori negative, were included in the study. The patients were then given esomeprazole 40 mg for 29 consecutive days, and the (13)C-UBT with the new test meal was performed the next morning...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28931984/reliability-and-validity-of-measuring-respiration-movement-using-a-wearable-strain-sensor-in-healthy-subjects
#9
Haijuan Liu, Shaopeng Guo, Kaipei Zheng, Xiaojun Guo, Tsugumi Kuramoto-Ahuja, Tamae Sato, Ko Onoda, Hitoshi Maruyama
[Purpose] The purpose of this research was to verify the reliability and validity of measuring respiration movement using a wearable strain sensor (WSS) which has been developed newly for clinical objective assessment. [Subjects and Methods] The 21 healthy male students were advised to conduct a breathing movement using measuring tape (MT) and WSS respectively, which was the measured at four locations on chest and abdomen wall. The different degree of chest expansion from maximal end of expiration to maximal end of inspiration was confirmed at each location...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28929509/task-dependent-output-of-human-parasternal-intercostal-motor-units-across-spinal-levels
#10
Anna L Hudson, Simon C Gandevia, Jane E Butler
During inspiration, there is differential activity in the human parasternal intercostal muscles across interspaces. We studied if the earlier recruitment of motor units in the rostral interspaces, compared to more caudal spaces, during inspiration is preserved for the non-respiratory task of ipsilateral trunk rotation. Single motor unit activity (SMU) was recorded from the first, second and fourth parasternal interspaces on the right side in five participants in two tasks: resting breathing and 'isometric' axial rotation of the trunk during apnoea...
September 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28928777/determination-of-salivary-urea-and-uric-acid-of-patients-with-halitosis
#11
Faezeh Khozeimeh, Nakisa Torabinia, Shirin Shahnaseri, Hooman Shafaee, Seyed Amir Mousavi
BACKGROUND: Halitosis is the presence of unpleasant or foul smelling breath. The origin of halitosis may be related to both systemic and oral conditions, but a large percentage of cases, about 90%, is generally related to an oral cause. The aim of this study was to compare the concentration of urea and uric acid in patients with halitosis and people without halitosis. MATERIALS AND METHODS: In this case-control study, concentration of urea and uric acid was compared between two groups: (1) persons suffering halitosis (2) control group without halitosis...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28928295/real-time-human-respiration-carbon-dioxide-measurement-device-for-cardiorespiratory-assessment
#12
Om Prakash Singh, Teo Aik Howe, Malarvili Balakrishnan
Development of a human respiration carbon dioxide (CO2) measurement device remains a demanding research to evaluate the cardio-respiratory status of human beings since last decades in and out of hospital. Hence, we report a real time, user operable CO2 measurement device using infrared CO2 sensor, Arduino Mega2560, and thin film transistor (TFT, 3.5"), incorporated with low pass (cut-off frequency,10Hz) and moving average (span,8) filters. The proposed device measures features such as partial end-tidal carbon dioxide (EtCO2), respiratory rate (RR), inspired carbon dioxide (ICO2) and newly proposed feature, Hjorth Activity that annotated with a date and time received from real-time clock and stores into the secure digital (SD) card...
September 20, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28927248/comparison-of-two-methods-for-the-in-vivo-diagnosis-of-helicobacter-pylori-infection-using-a-tablet-of-13c-urea
#13
Daniela Gilardi, Gionata Fiorino, Federica Furfaro, Marina F Alfieri, Ilaria Orlandi, Mariangela Allocca, Silvio Danese
BACKGROUND: The urea Breath-test is a widely-used method to detect the presence of Helicobacter pylori (HP) infection. Recently, new technologies were introduced, to obtain an immediate test result by continuous breath samples analysis after labeled urea intake. The total test duration is shorter than 20 minutes. METHODS: The study compared two diagnostic methods requiring the administration of EXPIROBACTER® (Sofar SpA, Trezzano Rosa, Milan, Italy) 100 mg as a source of labeled urea...
December 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28926794/depression-recognition-according-to-heart-rate-variability-using-bayesian-networks
#14
Danni Kuang, Rongqian Yang, Xiuwen Chen, Guohui Lao, Fengchun Wu, Xiong Huang, Ruixue Lv, Lei Zhang, Chuanxu Song, Shanxing Ou
BACKGROUND: Doctors mainly use scale tests and subjective judgment in the clinical diagnosis of depression. Researches have demonstrated that depression is associated with the dysfunction of the autonomic nervous system (ANS), where its modulation can be evaluated by heart rate variability (HRV). Depression patients have lower HRV than healthy subjects. Therefore, HRV may be used to distinguish depression patients from healthy people. METHODS: HRV signals were collected from 76 female subjects composed of 38 depression patients and 38 healthy people...
September 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28924619/breath-holding-endurance-stability-over-time-and-relationship-with-self-assessed-persistence
#15
Daisy G Y Thompson-Lake, Richard De La Garza Ii, Peter Hajek
Breath holding (BH) endurance has been suggested as a measure of the distress tolerance that could predict the outcome of attempts to implement behavior changes, such as stopping smoking or illicit substance use. It is not known however, to what degree BH endurance is a variable trait that may vary depending on situational context, or a stable state characteristic. We measured BH in two groups of participants at baseline and 22 and 89 days (N = 62 and N = 41) post-baseline and in a third group at multiple times points across a 5-week period (N = 44)...
September 2017: Heliyon
https://www.readbyqxmd.com/read/28924136/a-case-of-tracheobronchomalacia-mimicking-acute-pulmonary-embolism
#16
Stefani M Schwartz, Katherine J Greco, Venugopal Reddy
BACKGROUND Pulmonary embolism is a common acute postoperative complication and is associated with 100,000 deaths per year in the USA. Tracheobronchomalacia is an uncommon condition, which presents with similar symptoms to pulmonary embolism, including hypoxemia, tachycardia, and shortness of breath. We describe a case of a patient who presented with postoperative pulmonary symptoms that were initially thought to be due to pulmonary embolism. However, following imaging investigations these symptoms were found to be due to tracheobronchomalacia...
September 19, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28923758/methacholine-challenge-testing-a-novel-method-for-measuring-pd20
#17
Beth E Davis, Samuel K Simonson, Christianne M Blais, Donald W Cockcroft
BACKGROUND: New guidelines for methacholine challenge testing recommend reporting the test outcome as dose rather than concentration. Jet nebulizers have historically been used for methacholine challenge testing but much of the weight loss, often (incorrectly) referred to as aerosol output, is actually evaporation. The Wright® nebulizer is well characterized and still widely used, but its availability is unclear and it is non-disposable. We developed a novel method using a vibrating mesh nebulizer (Aerogen Solo®)...
September 15, 2017: Chest
https://www.readbyqxmd.com/read/28923022/the-association-of-sleep-disordered-breathing-with-left-ventricular-remodeling-in-cad-patients-a-cross-sectional-study
#18
Audrius Alonderis, Nijole Raskauskiene, Vaidute Gelziniene, Narseta Mickuviene, Julija Brozaitiene
BACKGROUND: There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and largely undiagnosed in patients with stable coronary artery disease (CAD). SDB affects 34% of men and 17% of women aged between 30 and 70. The objective of this study was to evaluate the association between SDB and left ventricular (LV) hypertrophy as well as structural remodeling in stable CAD patients. METHODS: The study was based on a cross-sectional design...
September 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28922433/bismuth-based-quadruple-therapy-following-h-pylori-eradication-failures-a-multicenter-study-in-clinical-practice
#19
Angelo Zullo, Vincenzo De Francesco, Annamaria Bellesia, Roberto Vassallo, Audenzio D'Angelo, Giuseppe Scaccianoce, Rodolfo Sacco, Giampaolo Bresci, Annarita Eramo, Anna Tanzilli, Lorenzo Ridola, Domenico Alvaro, Claudio Londoni, Gianfranco Brambilla, Raffaele Manta, Agostino Di Ciaula, Piero Portincasa
BACKGROUND AND AIMS: Helicobacter pylori (H. pylori) eradication in patients who failed one or more therapeutic attempts remains challenging. This study aimed to assess the efficacy of three-in-one capsules bismuth-based quadruple therapy (Pylera®) in these patients managed in clinical practice. METHODS: This was a prospective, open-label, multicenter study enrolling consecutive, adult patients with persistent H. pylori infection following at least one standard therapy...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922361/impact-of-four-different-recumbencies-on-the-distribution-of-ventilation-in-conscious-or-anaesthetized-spontaneously-breathing-beagle-dogs-an-electrical-impedance-tomography-study
#20
Tamas D Ambrisko, Johannes P Schramel, Ulrike Auer, Yves P S Moens
The aim was to examine the effects of recumbency and anaesthesia on distribution of ventilation in beagle dogs using Electrical Impedance Tomography (EIT). Nine healthy beagle dogs, aging 3.7±1.7 (mean±SD) years and weighing 16.3±1.6 kg, received a series of treatments in a fixed order on a single occasion. Conscious dogs were positioned in right lateral recumbency (RLR) and equipped with 32 EIT electrodes around the thorax. Following five minutes of equilibration, two minutes of EIT recordings were made in each recumbency in the following order: RLR, dorsal (DR), left (LLR) and sternal (SR)...
2017: PloS One
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