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Leukocytosis and infection

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https://www.readbyqxmd.com/read/29661462/donor-derived-candida-dubliniensis-resulting-in-perigraft-abscesses-in-a-liver-transplant-recipient-proven-by-whole-genome-sequencing-a-case-report
#1
Y E Teh, M L T Ang, M V La, V Gunalan, C K Tan, A L Tan, R T P Lin, T T Tan, P R Jeyaraj, S Cumaraswamy, B H Tan
BACKGROUND: The transmission of fungi via transplant, although well-known, has not often been molecularly proven. We describe a case of donor-derived candidiasis verified by whole genome sequencing. CASE DESCRIPTION: The multiorgan donor was a 42-year-old woman with subdural hemorrhage. Procurement of the thoracic organs was performed followed by the abdominal organs. Tissue from the left bronchus grew Candida dubliniensis. The liver recipient was a 63-year-old woman with cryptogenic liver cirrhosis...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29601312/myeloid-cells-regulate-plasma-ldl-cholesterol-levels
#2
Venetia Bazioti, Anouk M La Rose, Marit Westerterp
PURPOSE OF REVIEW: Leukocytosis, elevated blood leukocyte levels, is associated with enhanced cardiovascular risk in humans. Hematopoietic stem and progenitor cells (HSPCs) drive leukocyte production in a process called hematopoiesis, which mainly occurs in the bone marrow, and under certain conditions also in other organs such as the spleen. Cholesterol accumulation in HSPCs enhances hematopoiesis, increasing levels of blood monocytes that infiltrate into atherosclerotic plaques. Although HSPC proliferation and monocytosis enhance atherogenesis in several studies, concomitant decreases in LDL-cholesterol levels have also been reported, associated with anti-atherogenic effects...
March 29, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29587642/guillain-barre-syndrome-associated-with-hemorrhagic-fever-with-renal-syndrome-in-china-a-case-report
#3
Jie Jiao, Lei Wu, Jianyuan Yin, Xiaojiao Quan, Wei Chen, Jie Hu
BACKGROUND: We describe a case of Guillain-Barre syndrome (GBS) associated with hemorrhagic fever with renal syndrome. To our knowledge, only five cases of GBS associated with Hantavirus infection have been reported so far. CASE PRESENTATIONS: A 62-year-old man presented intermittent fever, chill and oliguria. According to remarkable leukocytosis, atypical lymphocytes, thrombocytopenia and former dwelling in hemorrhagic fever-endemic area, he was suspected as hemorrhagic fever with renal syndromeand certified with positive Hantavirus IgG...
March 27, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29581192/characterization-of-individual-human-antibodies-binding-pertussis-toxin-stimulated-by-acellular-immunization
#4
Edith Acquaye-Seedah, Elizabeth E Reczek, Hugh H Russell, Andrea M DiVenere, Sara O Sandman, Joseph H Collins, Caitlin A Stein, Timothy A Whitehead, Jennifer A Maynard
Despite high vaccination rates, the incidence of whooping cough has been steadily increasing in developing countries for several decades. The current acellular pertussis (aP) vaccines all include the major protective antigen pertussis toxin (PTx) and are safer, but appear less protective than infection or older whole cell vaccines. To better understand the attributes of individual antibodies stimulated by aP, we isolated plasmablast clones recognizing PTx after booster immunization of two donors. Five unique antibody sequences recognizing native PTx were recovered and expressed as recombinant human IgG1 antibodies...
March 26, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29564870/-nosocomial-infections-caused-by-multiresistant-pseudomonas-aeruginosa-carbapenems-included-predictive-and-prognostic-factors-a-prospective-study-2016-2017
#5
A Hernández, G Yagüe, E García Vázquez, M Simón, L Moreno Parrado, M Canteras, J Gómez
OBJECTIVE: Pseudomonas aeruginosa is one of the major pathogens causing hospital-acquired infections. In recent years, antimicrobial resistance is increasing and multidrug resistant (MDR) and extremely drug resistant (XDR) isolates have been associated with an increase of mortality. The aim of this study is to assess the clinical significance and analyze predictors and prognostic factors. METHODS: Prospective case-control non-paired study involving 64 patients with P...
March 21, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29558838/isavuconazole-therapy-in-an-flt3-mutated-acute-myeloid-leukemia-patient-receiving-midostaurin-a-case-report
#6
Eris Tollkuci
Midostaurin is the first approved FMS-related tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 mutated acute myeloid leukemia. Midostaurin is a major cytochrome P450 3A4 (CYP3A4) substrate. Coadministration with a strong CYP3A4 inhibitor or inducer can lead to a potential increase or decrease in midostaurin exposure. This report describes a 43-year-old patient with FLT3-internal tandem duplication (FLT3-ITD) positive acute myeloid leukemia who initially presented with leukocytosis and concern for acute leukemia...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29528007/ultrasonography-findings-of-urinary-tract-infection-after-kidney-transplant-a-case-report
#7
Sehnaz Tezcan, Ebru Ayvazoglu Soy, Nihal Uslu, Mehmet Haberal
Urinary tract infection is the most common complication after kidney transplant and often is associated with graft loss and mortality. Ultrasonography is the most widely applied imaging modality for diagnosis of complications after kidney transplant. Here, we report a case of a 52-year-old male patient who underwent renal transplant 1 month earlier and who presented with fever, leukocytosis, and leukocyturia. Klebsiella pneumoniae was found in the urine and blood cultures. Ultrasonography revealed multiple, ill-defined margined, hypoechoic areas and cysts within the cortex...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29524085/a-literature-review-of-blood-disseminated-p-marneffei-infection-and-a-case-study-of-this-infection-in-an-hiv-negative-child-with-comorbid-eosinophilia
#8
Xiu-Jing Han, Dan-Hong Su, Jian-Yun Yi, Ya-Wei Zou, Yu-Ling Shi
BACKGROUND: The typical manifestations of Penicillium marneffei (nowadays Talaromyces marneffei) infection in children without human immunodeficiency virus (HIV) remain unclear. The current work presents the case of a child without an underlying disease who was infected with P. marneffei comorbid with eosinophilia. CASE PRESENTATION: A 2-year-old male was infected with P. marneffei. A physical examination revealed a high-grade fever, ulcerated lesions in the oral mucosa, anemia, pruritic erythematous papules on the sac and thigh and watery diarrhea...
March 9, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29514129/comparative-study-of-effects-of-assemblages-aii-and-biv-of-giardia-duodenalis-on-mucosa-and-microbiota-of-the-small-intestine-in-mice
#9
Mariana Felgueira Pavanelli, Cristiane Maria Colli, Mônica Lúcia Gomes, Marcelo Biondaro Góis, Gessilda de Alcântara Nogueira de Melo, Eduardo José de Almeida Araújo, Débora de Mello Gonçales Sant'Ana
AIMS: Giardiasis is one of the major causes of diarrhea worldwide and its symptoms vary in intensity, which can be attributed to different parasite assemblages. The goal of the present study was to compare the effects of infection caused by assemblages AII and BIV ofGiardia duodenalis on the response of the small intestine, microbiota, and behavioral parameters in mice. MAIN METHODS: Swiss mice were infected with assemblages AII and BIV of G. duodenalis for 15 days...
March 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29504856/treatment-of-pyonephrosis-with-a-subcutaneous-ureteral-bypass-device-in-four-cats
#10
Megan Cray, Allyson C Berent, Chick W Weisse, Demetrius Bagley
CASE DESCRIPTION 4 cats were examined because of ureteral obstruction. CLINICAL FINDINGS Clinical and clinicopathologic abnormalities were nonspecific and included anorexia, lethargy, weight loss, anemia, leukocytosis, neutrophilia, lymphopenia, and azotemia. A diagnosis of pyonephrosis was made in all cats. The presence of bacteriuria was confirmed by means of urinalysis in 2 cats, bacterial culture of a urine sample obtained by means of preoperative cystocentesis in 2 cats, and bacterial culture of samples obtained from the renal pelvis intraoperatively in 3 cats...
March 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29487034/isolates-and-antibiotic-susceptibilities-of-endogenous-bacterial-endophthalmitis-a-retrospective-multicenter-study-in-japan
#11
Daisuke Todokoro, Kiyofumi Mochizuki, Takashi Nishida, Hiroshi Eguchi, Tatsuro Miyamoto, Takaaki Hattori, Takashi Suzuki, Tomoyuki Inoue, Ryohei Nejima, Saichi Hoshi, Hideo Akiyama
Endogenous bacterial endophthalmitis, also called metastatic endophthalmitis, is a rare bacterial endophthalmitis derived from distant infectious foci via the bloodstream. This infection can potentially cause not only severe visual disturbance, but also loss of the eyeball or death, as most patients are immunocompromised. This retrospective Japanese multicenter study analyzed 32 eyes in 25 definitive cases. Twelve patients (48.0%) had diabetes mellitus. Typical ocular findings were vitreous haze (87.5%), cells in the anterior chambers (62...
February 24, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29446580/is-there-any-difference-between-the-symptomatology-and-clinical-findings-of-viral-agents-causing-dehydration
#12
Suat Biçer, Defne Çöl, Öznur Küçük, Gülay Ç Erdağ, Tuba Giray, Meltem Uğraş, Ayça Vitrinel, Çiğdem Kaspar
BACKGROUND: Acute gastroenteritis is responsible for dehydration in many children. The viruses like rotavirus, norovirus, and adenovirus are considered the main causative agents of gastroenteritis. The goal of this study is the evaluation of the symptoms, clinical findings and hospitalization requirements in pediatric patients with dehydration secondary to viral gastroenteritis. METHODS: The distribution of age, symptoms, clinical and laboratory findings and hospitalization requirements of 156 viral acute gastroenteritis patients with moderate dehydration were evaluated retrospectively...
April 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29443761/haemolytic-uremic-syndrome-due-to-infection-with-adenovirus-a-case-report-and-literature-review
#13
Victoria Birlutiu, Rares Mircea Birlutiu
RATIONALE: Haemolytic-uremic syndrome is a rare but serious complication of bacterial and viral infections, which is characterized by the triad of: acute renal failure, microangiopathic haemolytic anemia and thrombocytopenia, sometimes severe, requiring peritoneal dialysis. In Europe, hemolytic-uremic syndrome (HUS) in paediatric pathology is primarily caused by Shiga toxin-producing Escherichia coli (STEC) O157, followed by O26. Beside these etiologies, there are other bacterial and viral infections, and also noninfectious ones that have been associated to lead to HUS as well: in the progression of neoplasia, medication-related, post-transplantation, during pregnancy or associated with the antiphospholipid syndrome, systemic lupus erythematosus or family causes with autosomal dominant or recessive inheritance...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441284/infected-renal-hematoma-in-a-healthy-adolescent-with-no-renal-structural-anomaly
#14
Sabrina Huq, Sherry Pejka, Dilip R Patel
Renal abscesses are uncommon in otherwise healthy children and adolescents who have no underlying renal structural anomalies. A previously healthy, immunocompetent, 14-year-old male without a history of abdominal trauma or urinary tract infection (UTI) was found to have a renal hematoma that became infected and developed into a renal abscess. He presented with a 2-day history of nausea, vomiting, fever and 1-day history of abdominal pain that radiated to the right flank. Clinical examination, blood work, and initial imaging indicated likely infection; however, findings were normal on urinalysis and urine culture had no growth...
January 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29380508/pneumonia-risks-in-bedridden-patients-receiving-oral-care-and-their-screening-tool-malnutrition-and-urinary-tract-infection-induced-inflammation
#15
Kaoru Matsusaka, Genichiro Kawakami, Hatsumi Kamekawa, Haruki Momma, Ryoichi Nagatomi, Jun Itoh, Mutsuo Yamaya
AIM: Pneumonia develops in bedridden patients even when they are receiving oral care. However, the pneumonia risk in bedridden patients remains unclear, and no screening tool has been developed to assess this risk by using daily hospital data. METHODS: We retrospectively examined pneumonia risk factors by analyzing the records of 102 bedridden patients receiving oral care. RESULTS: Body mass index, peripheral blood hemoglobin, and serum concentrations of total protein, albumin, total cholesterol and uric acid in the pneumonia group (n = 51; mean age 73...
January 30, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29374783/experimental-infection-in-cavia-porcellus-by-infected-amblyomma-ovale-nymphs-with-rickettsia-sp-atlantic-rainforest-strain
#16
Joice Magali Brustolin, Felipe da Silva Krawczak, Marta Elena Machado Alves, Maria Amélia Weiller, Camila Lopes de Souza, Fábio Brum Rosa, Gustavo Cauduro Cadore, Sônia Terezinha Dos Anjos Lopes, Marcelo Bahia Labruna, Fernanda Silveira Flores Vogel, Sônia de Avila Botton, Luís Antônio Sangioni
This study describes experimental infection of guinea pigs (Cavia porcellus) infested with naturally infected Amblyomma ovale nymphs with Rickettsia sp. (Atlantic rainforest strain), and the capacity of A. ovale nymphs to transmit this bacterium. Twenty-six guinea pigs were divided into the following groups: G1, 10 animals infested with uninfected A. ovale nymphs; G2, 10 animals infested with nymphs infected with Rickettsia sp. (Atlantic rainforest strain); and G3, 6 animals without tick infestation. Blood samples were taken 7, 14, 21, and 28 days post-infestation for serological and hematological tests...
January 27, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29371732/leukocyte-adhesion-defect-an-uncommon-immunodeficiency
#17
Sehar Nigar, Ejaz Ahmed Khan, Tahir Aziz Ahmad
Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency disorder with autosomal recessive inheritance which is characterized by presence of a defect of phagocytic function resulting from a lack of leukocyte cell surface expression of b2 integrin molecules (CD11 and CD18) that are essential for chemotaxis. The classic symptoms of the disease are failure of separation of the umbilical cord and recurrent bacterial infections, which continue throughout life. We describe here two cases of infants who presented with characteristic history of recurrent infections, delayed separation of umbilical cord and marked leukocytosis...
January 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29344094/robotic-prostatectomy-leading-to-a-delayed-mrsa-infected-lymphocele-a-case-report-and-review-of-the-literature
#18
Monica Kaminski, Rose Recco, Steven Siegel
Prostate cancer is the second leading cancer-related cause of death in the USA with the majority presenting as localized disease. In the last decade minimally invasive, robotic-assisted laparascopic, radical prostatectomy has become the most favored treatment choice. A complication that has been observed in 27% of patients is the formation of an asymptomatic lymphocele. It is a very rare complication for these to become infected, and when they do 80% have occurred 2-12 months post-procedure. In this case report the patient presented with fever and leukocytosis of unknown origin and was found to have a methicillin-resistant Staphylococcus aureus (MRSA) infected lymphocele over 2 years after a radical prostatectomy...
January 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29321404/a-clinicopathological-analysis-of-six-autopsy-cases-of-sudden-unexpected-death-due-to-infectious-aortitis-in-patients-with-aortic-tears
#19
Marin Ishikawa Kato, Mishie Ann Tanino, Masaya Miyazaki, Taichi Kimura, Yusuke Ishida, Lei Wang, Masumi Tsuda, Hiroshi Nishihara, Kazuo Nagashima, Shinya Tanaka
Objectives Cardiovascular disease is a leading cause of sudden unexpected death even in hospitalized patients. Infectious aortitis is a rare disease that has the potential to cause aortic tears and hemorrhage followed by sudden death. The aim of this study was to reveal the clinicopathological features of infectious aortitis that are related to sudden unexpected death. Methods We retrospectively reviewed 1,310 autopsy cases over 15 years and selected the cases involving patients who died suddenly due to aortic tears...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29310372/acute-kidney-injury-due-to-povidone-iodine-ingestion-a-case-report
#20
Chang Seong Kim, Sung Sun Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
RATIONALE: Povidone-iodine is a broad-spectrum antiseptic applied topically to treat wounds and prevent their infection. There have been several case reports of acute kidney injury (AKI) in burn patients after povidone-iodine irrigation and in patients receiving the substance as a sclerotherapy agent for management of lymphocele after renal transplantation. However, biopsy-confirmed AKI after ingestion of povidone-iodine has not previously been described. PATIENT CONCERNS: A 47-year-old man who had apparently ingested povidone-iodine solution and presented with nausea, vomiting, and reduced urine output...
December 2017: Medicine (Baltimore)
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