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https://www.readbyqxmd.com/read/28905639/clinical-manifestations-of-kawasaki-disease-shock-syndrome
#1
Le Ma, Ya-Yuan Zhang, Hai-Guo Yu
A case-control study was performed to ascertain clinical features of children who had been diagnosed as Kawasaki disease shock syndrome (KDSS), a severe condition related to Kawasaki disease (KD). Hospitalized patients were selected in Nanjing Children's Hospital. Demographic characteristics, clinical presentation, laboratory data, cardiovascular findings, and therapies were analyzed. Compared with the control group, KDSS patients were older and had more serious skin rash. The proportions of leukocytosis, neutrophilia, and hypoalbuminemia was higher, as was the level of while blood cell count, C-reactive protein, brain natriuretic peptide, and ferroprotein...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28903611/maternal-leukocytosis-after-antenatal-corticosteroid-administration-a-systematic-review-and-meta-analysis
#2
Melissa E Bauer, Laura K Price, Mark P MacEachern, Michelle Housey, Elizabeth S Langen, Samuel T Bauer
Although it is known that corticosteroid administration causes leukocytosis, the magnitude and length of time this leukocytosis persists is unknown during pregnancy. This study aimed to establish the expected range of maternal leukocytosis in healthy pregnant women at risk for preterm delivery after antenatal corticosteroid administration. PubMed, Embase and ClinicalTrials.gov were searched to identify the studies in healthy women at risk for preterm delivery without signs of clinical infection that reported white blood cell values preceding and after antenatal corticosteroid administration...
September 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28901345/-acute-alcoholic-hepatitis
#3
Gianni Testino, Emanuele Scafato, Valentino Patussi
Chronic alcohol related liver disease is characterized by a cascade of events defined as follows: steatosis, steatohepatitis/steatofibrosi, cirrhosis and hepatocellular carcinoma. On one of these histologic patterns may overlap acute alcoholic hepatitis (AAE) (mild, moderate, severe). Severe AAE can cause a severe clinical picture: jaundice with a duration of less than three months, jaundice in the first decompensation event, serum bilirubin higher than 5 mg/dL, ratio AST/ALT >2:1, AST less than 500 IU/L ALT <300 IU/L, neutrophil leukocytosis and increased GGT...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28895417/the-prognostic-value-of-pre-treatment-thrombocytosis-in-two-cohorts-of-patients-with-non-small-cell-lung-cancer-treated-with-curatively-intended-chemoradiotherapy
#4
G Holgersson, S BergstrOm, A Hallqvist, P Liv, J Nilsson, L WillEn, J Nyman, S Ekman, R Henriksson, M Bergqvist
Chemoradiotherapy is the standard of care for inoperable stage III non-small cell lung cancer (NSCLC). This treatment, however, offers only a small chance of cure and is associated with many side effects. Little research has been made concerning which patients benefit most/least from the treatment. The present study evaluates the prognostic value of anemia, leukocytosis and thrombocytosis at diagnosis in this treatment setting. In the present study, data were collected retrospectively for 222 patients from two different phase II studies conducted between 2002-2007 in Sweden with patients treated with chemoradiotherapy for stage IIIA-IIIB NSCLC...
September 12, 2017: Neoplasma
https://www.readbyqxmd.com/read/28894614/pancreatic-adenocarcinoma-producing-parathyroid-hormone-related-protein
#5
Reiko Yamada, Kyosuke Tanaka, Hiroyuki Inoue, Takashi Sakuno, Tetsuro Harada, Naohiko Yoshizawa, Hiroshi Miura, Toshihumi Takeuchi, Misaki Nakamura, Masaki Katsurahara, Yasuhiko Hamada, Noriyuki Horiki, Yoshiyuki Takei
A 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever. She was diagnosed with metastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection. Her serum concentration of granulocyte colony-stimulating factor was highly elevated. Forty-five days after initiating chemotherapy, she was readmitted because of a neuropsychiatric disturbance and hypercalcemia. Her serum concentration of parathyroid hormone-related protein (PTH-rP) was elevated. A pretreatment biopsy specimen showed strong cytoplasmic immunoreactivity to anti-PTH-rP antibody, suggesting that overproduction of PTH-rP accounted for the hypercalcemia...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28891234/retrospective-analysis-of-nonradiation-complications-in-dogs-undergoing-radiation-therapy
#6
John Farrelly, Qiuhu Shi
Dogs receiving radiation can develop complications unrelated to the radiation treatment. No study to date has described these complications in clinical patients undergoing multiple radiation therapy treatments. The purpose of this retrospective case-control study was to characterize the incidence and type of complications that occur in these dogs. A secondary goal was to evaluate whether patient and treatment characteristics could be identified to predict the risk of these complications. Medical records of 268 dogs receiving at least one radiation treatment at a single institution, between September, 2004 and June, 2007 were reviewed...
September 10, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28888888/sepsis-induced-by-cecal-ligation-and-perforation-clp-alters-nucleotidase-activities-in-platelets-of-rats
#7
Renata S Pereira, Claudia M Bertoncheli, Stephen A Adefegha, Lívia G Castilhos, Karine L Silveira, João Felipe P Rezer, Pedro H Doleski, Fátima H Abdalla, Karen F Santos, Claudio A M Leal, Roberto C V Santos, Emerson A Casali, Cesar E J Moritz, Daniel R Stainki, Daniela B R Leal
Sepsis is a potentially lethal condition, and it is associated with platelet alterations. The present study sought to investigate the activity of ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase), E-5'-nucleotidase, and ecto-adenosine deaminase (E-ADA) in the platelets of rats that were induced with sepsis. Male Wistar rats were divided into three groups of ten animals each: a negative control group (normal; NC); a group that underwent surgical procedures (sham); and a group that underwent cecal ligation and perforation (CLP)...
September 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28888855/cytomegalovirus-associated-severe-pneumonia-multi-organ-failure-and-ganciclovir-associated-arrhythmia-in-immunocompetent-child
#8
Ayman A Al-Eyadhy, Gamal Hasan, Rolan Bassrawi, Muneera Al-Jelaify, Mohamad-Hani Temsah, Ali Alhaboob, Fahad Al-Sohime, Majed Alabdulhafid
Cytomegalovirus (CMV) can rarely cause severe manifestations in immunocompetent individuals. Hereby, we report a twelve-year-old boy who presented with tachycardia, tachypnea, fever and leukocytosis, which progressed to hypoxemic respiratory failure and severe acute respiratory distress syndrome (ARDS). Subsequently, he developed multi-organ failure despite the ongoing full supportive care and empiric broad spectrum antibiotics. Cytomegalovirus infection was diagnosed by Polymerase Chain Reaction (PCR) in blood and histopathological examination of lung biopsy...
September 6, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28883735/hollow-viscus-injuries-predictors-of-outcome-and-role-of-diagnostic-delay
#9
Andrea Mingoli, Marco La Torre, Gioia Brachini, Gianluca Costa, Genoveffa Balducci, Barbara Frezza, Giovanna Sgarzini, Bruno Cirillo
INTRODUCTION: Hollow viscus injuries (HVIs) are uncommon but potentially catastrophic conditions with high mortality and morbidity rates. The aim of this study was to analyze our 16-year experience with patients undergoing surgery for blunt or penetrating bowel trauma to identify prognostic factors with particular attention to the influence of diagnostic delay on outcome. METHODS: From our multicenter trauma registry, we selected 169 consecutive patients with an HVI, enrolled from 2000 to 2016...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28878524/a-microbial-old-friend-with-a-new-face-a-rare-case-of-pyrexia-of-unknown-origin-and-leukemoid-reaction
#10
Sumeet P Mirgh, Virti D Shah, Jehangir S Sorabjee
We present a case of a young male, who presented to us with high-grade fever for more than four weeks, refractory seizures, multiple subcutaneous palpable lumps, and evidence of leukocytosis with predominant left shift on the peripheral smear. The classic "starry-sky" appearance on imaging, generalized muscular uptake on positron emission tomography-computerized tomography scan, and positive serology led to a diagnosis of disseminated cysticercosis. He responded to oral steroids. To the best of our knowledge, disseminated cysticercosis presenting as pyrexia of unknown origin and with a leukemoid reaction has never been reported in literature...
July 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28877132/parameters-for-ordering-blood-cultures-in-major-burn-injury-patients-improving-clinical-assessment
#11
James D Vargo, Jacob N Grow, Susan Yang, Abby Bernard, Niaman Nazir, Dhaval Bhavsar
Hypermetabolic and catabolic states in large TBSA burns lead to higher basal body temperature and tachycardia. These metabolic changes complicate the diagnosis of bacteremia and sepsis. Current indications for obtaining blood cultures (BCs) in this population are poorly described and nonstandardized. Fever, leukocytosis, and lactic acidosis are common during sepsis. This study aims to identify limits of these parameters with the highest rates of bacteremia. A retrospective review was performed for burn patients with > 20% TBSA between January 2009 and June 2011...
August 31, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28876655/a-retrospective-analysis-of-acute-appendicitis-ruptured-appendicitis-and-the-level-of-leukocytosis-in-paediatric-surgical-patients-of-nelson-mandela-central-hospital
#12
L Mtimba, A Dhaffala, S Z Molaoa
BACKGROUND: Appendicectomy is the most commonly performed operation worldwide. The diagnosis is predominantly based on clinical findings. Some patients will clinically be unclear if ruptured or acute inflamed appendicitis; the level of white cell count has been used as the predictor for ruptured appendicitis. METHOD: This was a retrospective chart review of paediatric surgical patients admitted at Nelson Mandela Central Hospital, Mthatha South Africa. RESULTS: A total of 214 patients with a diagnosis of acute appendicitis...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876654/ileosigmoid-knotting-a-zimbabwean-case-series
#13
C Mbanje, S Mungazi, A J V Maunganidze
BACKGROUND: Ileosigmoid knotting is a rare cause of intestinal obstruction with a rapidly progressive course, for which expedient surgical intervention is required to avoid mortality. METHOD: A combined retrospective and prospective analysis was performed on 16 patients operated on at PGH with an operative diagnosis of ileosigmoid knotting between February 2011 and April 2016. Data inclusive of demographics, time to presentation and surgery, preoperative diagnostic accuracy, incidence of septic shock and mortality was collected...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28875344/sweet-s-syndrome-a-clinical-entity-need-to-discriminate-against-acute-haematogenous-periprosthetic-joint-infection
#14
Ju Hong Lee, Ki Bum Kim, Ju Rang Lee, Myougn Ja Chung, Sung Il Wang
Sweet's syndrome (SS) or acute febrile neutrophilic dermatosis is an uncommon condition. It is characterized by fever, polymorphonuclear leukocytosis, painful erythematous cutaneous plaques, and dense dermal infiltrate of neutrophils without vasculitis at the site of skin lesions. Lesions in SS might enlarge and coalesce with increasing dermal oedema, resulting in pseudo-vesicular appearance mimicking joint infections. Here, a rare case of SS mimicking acute haematogenous periprosthetic infection in a 74-year-old woman with a history of total knee arthroplasty is reported...
September 5, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28873411/preoperative-asymptomatic-leukocytosis-and-postoperative-outcome-in-cardiac-surgery-patients
#15
Eitezaz Mahmood, Ziyad O Knio, Feroze Mahmood, Rabia Amir, Sajid Shahul, Bilal Mahmood, Yanick Baribeau, Ariel Mueller, Robina Matyal
BACKGROUND: Despite showing a prognostic value in general surgical patients, preoperative asymptomatic elevated white blood cell (WBC) count is not considered a risk factor for cardiac surgery. Whereas there is sporadic evidence of its value as a preoperative risk marker, it has not been looked at methodically as a specific index of outcome during cardiac surgery. Using a national database we sought to determine the relationship between preoperative WBC count and postoperative outcome in cardiac surgical patients...
2017: PloS One
https://www.readbyqxmd.com/read/28872973/splenectomy-induced-leukocytosis-promotes-intratumoral-accumulation-of-myeloid-derived-suppressor-cells-angiogenesis-and-metastasis
#16
Murat Sevmis, Digdem Yoyen-Ermis, Cisel Aydin, Elif Bilgic, Petek Korkusuz, Aysegul Uner, Erhan Hamaloglu, Gunes Esendagli, Derya Karakoc
BACKGROUND: Enlargement of the spleen is commonly observed in animal models of cancer. Here, in a breast cancer model, it was aimed to determine the effect of splenectomy on circulating and tumor-infiltrating myeloid-derived suppressor cells (MDSCs), tumor angiogenesis, and metastasis. METHODS: Mice were inoculated with 4T1 breast cancer cells and underwent splenectomy or sham laparotomy. Tumor growth and survival of animals were followed. Macroscopic and histopathological analyses were performed to determine splenomegaly and metastasis...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28872570/when-fever-leukocytosis-and-right-lower-quadrant-pain-is-not-appendicitis
#17
Jeanette Kurbedin, Lawrence Haines, Marla C Levine, Eitan Dickman
Mesenteric cystic lymphangioma (MCL) is an uncommon, benign, slow-growing abdominal tumor that is derived from the lymphatic vessels (World J Gastroenterol. 2012;18:6328-6332, Radiographics. 1994;14:729-737). It is most often diagnosed in the head and neck of affected children. Rarely, a lymphangioma can develop within the small bowel (Pan Afr Med J. 2012;12:7). The clinical presentation of patients with an abdominal MCL can range from asymptomatic to acute abdominal pain (J Korean Surg Soc. 2012;83:102-106)...
September 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28871925/mast-cell-disorders-melanoma-and-pancreatic-carcinoma-from-a-clinical-observation-to-a-brief-review-of-the-literature
#18
Giovanni Paolino, Maria Belmonte, Stefania Trasarti, Michelina Santopietro, Luisa Bizzoni, Mara Riminucci, Luisa Cardarelli, Emilia Iannella, Marcello Albanesi, Elisa Moliterni, Dario Didona, Stefano Calvieri, Robin Foà, Fiorina Giona
Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28869184/the-treatment-landscape-of-myelofibrosis-before-and-after-ruxolitinib-approval
#19
Andrew T Kuykendall, Chetasi Talati, Najla Al Ali, Kendra Sweet, Eric Padron, David A Sallman, Jeffrey E Lancet, Alan F List, Kenneth S Zuckerman, Rami S Komrokji
INTRODUCTION/BACKGROUND: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm that presents with a heterogeneous clinical phenotype and prognosis. Before the US Food and Drug Administration approval of ruxolitinib, treatment options were varied and had limited effect. The increased use of ruxolitinib has drastically altered the MF treatment landscape. In this study, we aimed to clarify the clinical situations in which ruxolitinib is being used and analyze its effect on this landscape...
August 5, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28868006/sweet-s-syndrome-arising-in-a-scar
#20
Casey M Chern, Michael Royer, Winston Turnage
Acute febrile neutrophilic dermatosis (Sweet's syndrome) is an uncommon inflammatory cutaneous disorder. It presents with lesions which are tender, erythematous, edematous papules and under histologic examination show dense neutrophilic infiltration of the dermis. These lesions are often accompanied by leukocytosis and fever. This paper reports a unique case of acute febrile neutrophilic dermatosis presenting as a Koebner response to a linear scar.
May 2017: Case Reports in Dermatology
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