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https://www.readbyqxmd.com/read/28632826/-pyogenic-liver-abscess-in-children-clinical-experience-in-a-pediatric-reference-center
#1
Carolina Carballo, Claudia Cazes, Mariana Matsuda, M Laura Praino, Noemí Rivas, Eduardo López
INTRODUCTION: Liver abscess is a serious and an uncommon pediatric disease. OBJECTIVE AND METHOD: Description of 20 pediatric patients with liver abscess admitted in "Ricardo Gutierrez" Children's Hospital, a Tertiary Reference Center of Buenos Aires, between 2009 and 2015. RESULTS: The hospitalization rate was 35/100.000 admissions. Median age was 5 years old, male/female ratio 4/1. Five patients (25%) had predisposing factors. Median days at diagnosis were 12...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28625029/-a-case-of-squamous-cell-carcinoma-in-bladder-diverticulum-producing-granulocyte-colony-stimulating-factor
#2
Koichi Uemura, Kazuhiro Namura, Susumu Umemoto, Osamu Matsubara, Koichi Udagawa
We report a rare case of squamous cell carcinoma (SCC) in bladder diverticulum producing granulocyte colony stimulating factor (G-CSF). A 59-year-old man complaining of hematuria and right hip pain was admitted with a large cancer in the bladder diverticulum. His laboratory data showed leukocytosis of 20,100/ μ l (neutrophils : 92%) with an elevated G-CSF of 76. 6 pg/ml in the peripheral blood. After neoadjuvant chemotherapy (gemcitabine and cisplatin), radical cystectomy was performed to normalize serum leukocytosis and G-CSF...
May 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28611630/sweet-s-syndrome-successfully-treated-with-granulocyte-and-monocyte-adsorption-apheresis
#3
Asami Fujii, Yoko Mizutani, Yuki Hattori, Tomoko Takahashi, Hidenori Ohnishi, Shozo Yoshida, Mariko Seishima
Sweet's syndrome is a neutrophilic dermatosis characterized by an abrupt onset of painful erythematous lesions showing neutrophilic infiltrates in the dermis. Fever and an elevated neutrophil level are generally observed. Sweet's syndrome may be idiopathic, malignancy-associated, or drug-induced (mainly involving granulocyte colony-stimulating factor (G-CSF) administration). Although systemic corticosteroids are usually effective, the symptoms of Sweet's syndrome recur in some refractory cases. Herein, we report a case of a 55-year-old Japanese woman with recurrent symptoms of fever (>39°C) and painful erythematous lesions on her four extremities, trunk, and neck...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28604181/reference-values-for-maternal-total-and-differential-leukocyte-counts-in-different-trimesters-of-pregnancy-and-the-initial-postpartum-period-in-western-turkey
#4
Muzaffer Sanci, Emrah Töz, Onur Ince, Aykut Özcan, Kevser Polater, Abdurrahman Hamdi Inan, Emrah Beyan, Emrah Akkaya
The aim of this study was to investigate alterations in the leukocyte and differential leukocyte counts in different trimesters of pregnancy and the initial postpartum period. The study population consisted of 40,325 pregnant women. A full blood count and automated differential leukocyte count were performed and all the haemogram results in the different trimesters of pregnancy were recorded. Percentiles were calculated using statistical software. A total of 82,786 complete blood count evaluations were performed in 40,325 subjects from the 6th to 41st week of pregnancy and in the initial postpartum period...
July 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28601551/patients-with-post-essential-thrombocythemia-and-post-polycythemia-vera-differ-from-patients-with-primary-myelofibrosis
#5
Lucia Masarova, Prithviraj Bose, Naval Daver, Naveen Pemmaraju, Kate J Newberry, Taghi Manshouri, Jorge Cortes, Hagop M Kantarjian, Srdan Verstovsek
Prognostic scoring systems for primary myelofibrosis (PMF) are not accurate in patients with post-essential thrombocythemia and post-polycythemia vera myelofibrosis (PET-MF; PPV-MF). Given the paucity of data describing the clinical characteristics, disease course and outcomes of these patients, we sought to describe and compare the clinical characteristics and outcomes of 755 patients with PMF, 181 with PPV-MF, and 163 with PET-MF referred to our institution between 1984 and 2013. The median follow-up was 31 months, and 56% (n=616) patients had died...
June 2, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28599265/house-dust-endotoxin-and-peripheral-leukocyte-counts-results-from-two-large-epidemiologic-studies
#6
(no author information available yet)
BACKGROUND: The peripheral leukocyte count is a biomarker of inflammation and is associated with human all-cause mortality. Although causes of acute leukocytosis are well-described, chronic environmental determinants of leukocyte number are less well understood. OBJECTIVES: We investigated the relationship between house dust endotoxin concentration and peripheral leukocyte counts in human subjects. METHODS: The endotoxin-leukocyte relationship was evaluated by linear regression in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 () and the Agricultural Lung Health Study (ALHS; )...
May 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28598059/cardiac-abscess-with-ventricular-aneurysm-secondary-to-old-myocardial-infarction
#7
N Nand, S K Singla, S Magu
Myocardial Abscess (MA) is a rare life threatening condition mostly occurring secondary to underlying infective endocarditis. But it can also be found secondary to septicemia with some unknown focus of sepsis in the body. Development of MA as a consequence of left ventricular aneurysm (LVA) secondary to myocardial infarction is very rare. We report the case of 56 year old male, who presented with high grade fever and leukocytosis. On detailed evaluation, he was found to have a myocardial abscess with underlying LVA...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28592301/pneumococcal-meningitis-with-normal-cerebrospinal-biochemistry-and-no-pneumococci-at-microscopy-mimicking-a-stroke-a-case-report
#8
Gideon Ertner, Jeppe Romme Christensen, Christian T Brandt
BACKGROUND: Bacterial meningitis commonly presents with symptoms such as headache, impaired consciousness, neck stiffness, and fever. In most cases, cerebrospinal fluid analysis will yield white cell counts >100/mm(3). Atypical presentations occur, especially in the very young or very elderly and the immunocompromised. We report an unusual case of pneumococcal meningitis in a healthy 78-year-old Danish woman who presented with clinical features mimicking a stroke with normal cerebrospinal fluid parameters and without microscopic evidence of bacteria...
June 7, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28588769/the-glasgow-prognostic-score-useful-information-when-prescribing-palliative-radiotherapy
#9
Carsten Nieder, Bård Mannsåker, Astrid Dalhaug, Adam Pawinski, Ellinor Haukland
The purpose of the present retrospective study was to investigate whether a score reflecting systemic inflammatory processes [the Glasgow Prognostic Score (GPS)] provides relevant information for radiation oncologists. GPS is a three-tiered score [0: normal C-reactive protein (CRP) and albumin; 1: one abnormal result; 2: increased CRP and low albumin]. Correlations between disease type and extent, resource utilization, survival and GPS were analyzed in 703 patients. In the subgroup with GPS 2, significantly higher rates of lung, adrenal gland and liver metastases were observed...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28587816/prognostic-value-of-the-preoperative-platelet-to-leukocyte-ratio-for-oncologic-outcomes-in-patients-undergoing-radical-cystectomy-for-bladder-cancer
#10
Gerald B Schulz, Tobias Grimm, Alexander Buchner, Friedrich Jokisch, Markus Grabbert, Birte-Swantje Schneevoigt, Alexander Kretschmer, Christian G Stief, Alexander Karl
BACKGROUND: Currently, stratification of patients with bladder cancer (BC) mainly relies on histopathologic and clinical staging. Furthermore, inflammation plays an important role in the pathogenesis of BC. With the preoperative platelet-to-leukocyte ratio (PLR), we introduce a novel prognostic marker based on routine hematologic values in patients undergoing radical cystectomy (RC). PATIENTS AND METHODS: In our cohort of 665 patients undergoing RC (2004-2015) for urothelial carcinoma of the bladder (UCB), we analyzed a variety of preoperative hematologic parameters...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28575571/-age-related-peculiarities-of-acute-cholecystitis
#11
M B Polyanskiy, D P Nazarenko, T A Ishunina
In the present study the analysis of dynamics of basic laboratory parameters of patients with acute cholecystitis (AC) in the four age groups subdivided according to the WHO classification into young, middle age, elderly and senile was carried out. The most pronounced changes were found in the senile age group in which the AC was accompanied by the decreased number of erythrocytes, low hemoglobin and total protein, leukocytosis, lower percentage of lymphocytes and the highest levels of ALT, AST, bilirubin and urea...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28572615/characterization-of-pertussis-like-toxin-from-salmonella-spp-that-catalyzes-adp-ribosylation-of-g-proteins
#12
Yukino Tamamura, Kiyoshi Tanaka, Ikuo Uchida
Salmonella Typhimurium definitive phage type (DT) 104 produces a pertussis-like toxin (ArtAB-DT104), which catalyzes ADP-ribosylation of pertussis toxin sensitive G proteins. However, the prevalence of ArtAB and its toxicity have not been established. We report here that, in addition to DT104, S. Worthington, and S. bongori, produce ArtAB homologs, designated ArtAB-SW and ArtAB-Sb, respectively. We purified and characterized these ArtAB toxins, which comprise a 27-kDa A subunit (ArtA) and 13.8-kDa pentameric B subunits (ArtB)...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28571943/hematological-alterations-and-splenic-t-lymphocyte-polarization-at-the-crest-of-snake-venom-induced-acute-kidney-injury-in-adult-male-mice
#13
Farhat Nasim, Sreyasi Das, Roshnara Mishra, Raghwendra Mishra
Snake venom induced acute kidney injury (SAKI) is of great clinical relevance in tropical countries. Involvement of T cell, a key mediator of AKI and its remission, is least explored in SAKI. In the present study the in vivo hematological alterations and associated splenic T cell polarization is probed in order to investigate the immune response at the crest of Russell's viper venom (RVV) induced AKI in experimental murine model. Based on a dose and time kinetic study intra muscular injection dose of 20 μg RVV/100 gm body weight of mice and incubation period of 60 h was selected for induction of SAKI...
May 29, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28571941/clinical-predictors-of-isolated-tubal-torsion-a-case-series
#14
K W Webster, S M Scott, P S Huguelet
STUDY OBJECTIVE: A rare cause of adolescent abdominal pain includes isolated tubal torsion (ITT). Presentation is nonspecific and few studies have investigated adolescents. Our study objective is to describe the presentation and management of ITT in a large case series. DESIGN: Retrospective observational case series. SETTING: Tertiary care children's hospital. PARTICIPANTS: Females aged 3-21, presenting to Children's Hospital Colorado and diagnosed with ITT between January 2004 and August 2015...
May 29, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28559823/serum-g-csf-may-be-a-more-valuable-biomarker-than-image-evaluation-in-g-csf-producing-urothelial-carcinoma-a-case-report
#15
Kento Morozumi, Shunichi Namiki, Takashi Kudo, Masataka Aizawa, Naomasa Ioritani
Granulocyte colony-stimulating factor (G-CSF)-producing urothelial carcinomas (UCs) are rare and have a poor prognosis. According to the literature, treatment for G-CSF-producing UCs is very difficult. We experienced 2 cases of UC presenting with leukocytosis. In these cases, serum G-CSF levels were higher than the reference value with leukocytosis at diagnosis, and the resected specimens were positive for anti-G-CSF immunostaining. One case had a good prognosis and the other case died after 9 months from diagnosis...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28558478/bacteria-on-urine-microscopy-is-not-associated-with-systemic-infection-in-patients-with-obstructing-urolithiasis
#16
Felix Cheung, Charles A Loeb, Michael P Croglio, Wayne C Waltzer, Steven J Weissbart
INTRODUCTION: Determining if bacterial presence on urine microscopy represents clinical infection is important as urinary drainage is indicated in patients with obstructing urolithiasis and concomitant urinary tract infection. We aim to investigate if the presence of bacteria on urine microscopy is associated with markers of infection in patients with obstructing urolithiasis presenting to the emergency room. METHODS: A cross-sectional study was performed on 199 patients with obstructing urolithiasis divided into two groups according to the presence of bacteria on urine microscopy...
May 30, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28553755/cardiac-rehabilitation-in-patients-with-st-segment-elevation-myocardial-infarction-can-its-failure-be-predicted
#17
Robert Irzmański, Joanna Kapusta, Agnieszka Obrębska-Stefaniak, Beata Urzędowicz, Jan Kowalski
BACKGROUND: The prognosis in patients after acute coronary syndromes (ACS) is significantly burdened by coexisting anaemia, leukocytosis and low glomerular filtration rate (GFR). Hyperglycaemia in the early stages of ACS is a strong predictor of death and heart failure in non-diabetic subjects. This study aimed to evaluate the effect of hyperglycaemia, anaemia, leukocytosis, thrombocytopaenia and decreased GFR on the risk of the failure of cardiac rehabilitation (phase II at the hospital) in post-ST-segment elevation myocardial infarction (STEMI) patients...
May 1, 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28552748/characterization-of-a-previously-unrecognized-clinical-phenomenon-delayed-shock-following-cardiac-implantable-electronic-device-extraction
#18
M D ArwaYounis, Roy Beinart, Nofrat Nehoray, Elad Asher, Shlomy Matetzky, Roy Beigel, Anat Wieder, Michael Glikson, Eyal Nof
BACKGROUND: Transvenous Lead Extraction (TLE) remains a challenging procedure with inherent risk and associated complications. OBJECTIVE: We sought to characterize and evaluate predictors for delayed shock following a TLE with no intra-procedural complications. METHODS: We retrospectively analyzed data of 217 consecutive patients who underwent extraction between 2010-2015. The primary end point was sudden onset of shock more than four hours following the completion of the procedure...
May 25, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28552727/disseminated-intravascular-coagulation-caused-by-moojenactivase-a-procoagulant-snake-venom-metalloprotease
#19
Marco A Sartim, Gabriel N Cezarette, Anna L Jacob-Ferreira, Fabiani G Frantz, Lucia H Faccioli, Suely V Sampaio
Snake venom toxins that activate coagulation factors are key players in the process of venom-induced coagulopathy, and account for severe clinical manifestations. The present study applies a variety of biochemical, hematological, and histopathological approaches to broadly investigate the intravascular and systemic effects of moojenactivase (MooA), the first described PIIId subclass metalloprotease isolated from Bothrops sp. venom that activates coagulation factors. MooA induced consumption coagulopathy with high toxic potency, characterized by prolongation of prothrombin and activated partial thromboplastin time, consumption of fibrinogen and the plasma coagulation factors X and II, and thrombocytopenia...
May 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28551329/myeloproliferative-neoplasms-with-t-8-22-p11-2-q11-2-bcr-fgfr1-a-meta-analysis-of-20-cases-shows-cytogenetic-progression-with-b-lymphoid-blast-phase
#20
Ximena Montenegro-Garreaud, Roberto N Miranda, Alexandra Reynolds, Guilin Tang, Sa A Wang, Mariko Yabe, Wei Wang, Lianghua Fang, Carlos E Bueso-Ramos, Pei Lin, L Jeffrey Medeiros, Xinyan Lu
Rearrangements of FGFR1 result in the 8p11 myeloproliferative syndrome, a group of rare diseases that features a myeloproliferative neoplasm (MPN) that commonly progresses to lymphoblastic leukemia/lymphoma or acute myeloid leukemia. The most common partner of the FGFR1 is ZMYM2 and patients with the ZMYM2-FGFR1 fusion often present with MPN and T-lymphoblastic lymphoma. There are 14 other partners that can fuse with the FGFR1 and of interest is the BCR-FGFR1 fusion that results from t(8;22)(p11.2;q11.2). Patients with t(8;22) often show leukocytosis and present with an MPN resembling chronic myeloid leukemia (CML) or very rarely, with B lymphoblastic leukemia (B-ALL)...
May 24, 2017: Human Pathology
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