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https://www.readbyqxmd.com/read/29683203/risk-of-recurrence-and-death-in-patients-with-breast-cancer-after-delayed-deep-inferior-epigastric-perforator-flap-reconstruction
#1
H Adam, A C Docherty Skogh, Å Edsander Nord, I Schultz, J Gahm, P Hall, J Frisell, M Halle, J de Boniface
BACKGROUND: Postmastectomy reconstruction using a deep inferior epigastric perforator (DIEP) flap is increasingly being performed in patients with breast cancer. The procedure induces extensive tissue trauma, and it has been hypothesized that the release of growth factors, angiogenic agonists and immunomodulating factors may reactivate dormant micrometastasis. The aim of the present study was to estimate the risk of breast cancer recurrence in patients undergoing DIEP flap reconstruction compared with that in patients treated with mastectomy alone...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29675632/factors-affecting-mortality-and-reoperations-in-high-energy-pelvic-fractures
#2
Peyman Bakhshayesh, Lars Weidenhielm, Anders Enocson
AIM: Factors affecting mortality during the first year following high-energy pelvic fractures has not been reported previously. Nor has surgical complications leading to reoperations been reported in a cohort with only high-energy pelvic trauma patients. OBJECTIVES: The aim of this study was to report and analyse factors affecting outcome, in terms of mortality and reoperations, up to 1 year after the injury in patients with a traumatic pelvic ring injury due to a high-energy trauma...
April 19, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29671707/prediction-of-cognitive-performance-and-subjective-sleepiness-using-a-model-of-arousal-dynamics
#3
Svetlana Postnova, Steven W Lockley, Peter A Robinson
A model of arousal dynamics is applied to predict objective performance and subjective sleepiness measures, including lapses and reaction time on a visual Performance Vigilance Test (vPVT), performance on a mathematical addition task (ADD), and the Karolinska Sleepiness Scale (KSS). The arousal dynamics model is comprised of a physiologically based flip-flop switch between the wake- and sleep-active neuronal populations and a dynamic circadian oscillator, thus allowing prediction of sleep propensity. Published group-level experimental constant routine (CR) and forced desynchrony (FD) data are used to calibrate the model to predict performance and sleepiness...
April 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29671128/a-phase-i-study-of-the-pharmacokinetics-and-pharmacodynamics-of-intranasal-doxylamine-in-subjects-with-chronic-intermittent-sleep-impairment
#4
Mark Allison, Cecilia Hale
INTRODUCTION: Doxylamine tablets are approved as an over-the-counter sleep aid. We developed a doxylamine succinate intranasal metered-dose delivery system with the expectation of a more rapid onset of action with reduced side-effect potential compared with the oral tablet. METHODS: This phase I study randomized 24 adults with chronic intermittent sleep impairment to receive either single doses of intranasal doxylamine succinate 3.2, 6.3, or 12.7 mg or doxylamine succinate 25-mg oral tablet...
April 18, 2018: Drugs in R&D
https://www.readbyqxmd.com/read/29664536/-p-lynch-syndrome-is-a-major-cause-of-monogenetic-familial-colorectal-cancer-p
#5
Sophie Walton Bernstedt, Jan Björk, Ann-Sofie Backman, Miriam Mints, Erik Björck
Individuals with a history of colorectal or endometrial cancer younger than 50 years of age or with relatives younger than 50 years of age with a history of any of these malignances should be referred to clinical genetics for further diagnostic examinations and genetic counseling. Lynch syndrome is caused by mutations in mismatch repair genes and implicates an increased risk for colorectal cancer as well as endometrial cancer. Routine surveillance for this group of individuals regarding colorectal cancer by means of colonoscopy and endometrial cancer by means of transvaginal ultrasound as well as endometrial biopsies is recommended annually or biennially...
April 16, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29624618/invasive-infection-caused-by-klebsiella-pneumoniae-is-a-disease-affecting-patients-with-high-comorbidity-and-associated-with-high-long-term-mortality
#6
M Vading, P Nauclér, M Kalin, C G Giske
Klebsiella pneumoniae (KP) is after Escherichia coli (EC) the most common gram-negative species causing invasive infections. Herein, we analyzed risk factors and prognosis in invasive infections caused by KP versus EC, in an area with low antimicrobial resistance. Moreover, we compared antimicrobial resistance and relative prevalence of KP and EC (KP/EC-ratio) in different European countries, using EARS-Net data. Adult patients admitted to Karolinska University Hospital 2006-2012 with invasive infection caused by KP (n = 599) were matched regarding sex and age with patients infected by EC...
2018: PloS One
https://www.readbyqxmd.com/read/29614489/hyperbaric-oxygen-therapy-as-adjuvant-treatment-for-hardware-related-infections-in-neuromodulation
#7
Jiri Bartek, Simon Skyrman, Michael Nekludov, Tiit Mathiesen, Folke Lind, Gaston Schechtmann
BACKGROUND: In neuromodulation therapies, hardware-related infections are a major challenge often leading to hardware removal. OBJECTIVE: To investigate the role of adjuvant hyperbaric oxygen therapy (HBOT) in hardware-related infections. METHODS: Fourteen hardware-related infection events in 12 consecutive patients between 2002 and 2015 were treated with antibiotics and adjuvant HBOT at the Karolinska University Hospital (Stockholm, Sweden)...
April 3, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29603032/association-of-reproductive-history-with-breast-tissue-characteristics-and-receptor-status-in-the-normal-breast
#8
Marike Gabrielson, Flaminia Chiesa, Catharina Behmer, Katarina Rönnow, Kamila Czene, Per Hall
INTRODUCTION: Reproductive history has been associated with breast cancer risk, but more knowledge of the underlying biological mechanisms is needed. Because of limited data on normal breast tissue from healthy women, we examined associations of reproductive history and established breast cancer risk factors with breast tissue composition and markers of hormone receptors and proliferation in a nested study within the Karolinska Mammography project for risk prediction for breast cancer (Karma)...
March 30, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29580071/metabolic-syndrome-components-is-there-a-difference-according-to-exposure-to-night-work
#9
Narriane Chaves Pereira de Holanda, Claudia Roberta de Castro Moreno, Elaine Cristina Marqueze
The aim of this study was to compare metabolic aspects potentially associated with metabolic syndrome (MetS), in addition to serum leptin levels and sleep, according to exposure to night work among nursing staff. A cross-sectional study involving 60 nursing staff was conducted. Sociodemographic, sleep (Karolinska Sleep Questionnaire), physical activity (International Physical Activity Questionnaire), and nutrition data (16-Food Intake Questionnaire) were collected. Body measurements and blood pressure were taken and blood collected to determine glycemia, total cholesterol and portions of low-density lipoprotein and high-density lipoprotein and triglycerides, and leptin levels...
March 26, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29552959/milestones-in-nordic-health-promotion-research
#10
Bo J A Haglund, Per Tillgren
Based on the storytelling tradition and analyses of conference material, this article provides an overview of the evolving Nordic Health Promotion Research Network (NHPRN) and its conferences over the last 20 years. The story goes from the planning of the first conference in Bergen, Norway, back in 1996 to the eighth conference in Jyväskylä, Finland, in 2016. There have been three phases of development. During the first phase, 1996-2007, the five first conferences were initiated and implemented by departments of public health in the Nordic countries...
February 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29543136/effect-of-sleep-deprivation-on-diurnal-variation-of-vertical-perception-and-postural-control
#11
Tristan Martin, Antoine Gauthier, Zhang Ying, Nicolas Benguigui, Sebastien Moussay, Jan Bulla, Damien Davenne, Nicolas Bessot
The aim of the study was to test the effect of total sleep deprivation on performance and time-of-day pattern of Subjective Visual Vertical (SVV) and postural control. Nineteen healthy young participants (4 females and 15 males 21.9 {plus minus} 1.2 years) were engaged in two counterbalanced experimental sessions with or without total sleep deprivation. Oral temperature, Karolinska sleepiness scale and visual analogic scale for fatigue, postural control and SVV were randomly measured every 4h, from 6:00 h to 22:00 h...
March 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29522213/cecilia-linde-md-phd-karolinska-institute-sweden
#12
Judy Ozkan
No abstract text is available yet for this article.
March 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29514648/long-term-smoking-alters-abundance-of-over-half-of-the-proteome-in-bronchoalveolar-lavage-cell-in-smokers-with-normal-spirometry-with-effects-on-molecular-pathways-associated-with-copd
#13
Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K Garberg, Reza Karimi, Johan Grunewald, Frode S Berven, C Magnus Sköld, Åsa M Wheelock
BACKGROUND: Smoking represents a significant risk factor for many chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). METHODS: To identify dysregulation of specific proteins and pathways in bronchoalveolar lavage (BAL) cells associated with smoking, isobaric tags for relative and absolute quantitation (iTRAQ)-based shotgun proteomics analyses were performed on BAL cells from healthy never-smokers and smokers with normal lung function from the Karolinska COSMIC cohort...
March 8, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29511011/the-influence-of-hazardous-drinking-on-psychological-functioning-stress-and-sleep-during-and-after-treatment-in-patients-with-mental-health-problems-a-secondary-analysis-of-a-randomised-controlled-intervention-study
#14
Catharina Strid, Claes Andersson, Agneta Öjehagen
OBJECTIVES: Hazardous drinking could negatively affect health and lead to alcohol use disorders, but it is unclear how hazardous drinking affects treatment outcomes of depression and anxiety and stress-related mental health problems. The aim of this study was to examine whether hazardous drinking, measured by Alcohol Use Disorders Identification Test-Consumption (AUDIT-C), influences the outcomes of repeated assessments of psychological functioning (Outcome Questionnaire-45), stress (Perceived Stress Scale) and sleep (Karolinska Sleep Questionnaire), during and after treatment in patients with mental ill health...
March 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29500954/alcohol-metabolism-in-hangover-sensitive-versus-hangover-resistant-social-drinkers
#15
M Mackus, M van Schrojenstein Lantman, A J A E Van de Loo, A D Kraneveld, J Garssen, K A Brookhuis, J C Verster
BACKGROUND: Previous research demonstrated that urinary ethanol concentrations were significantly lower in hangover resistant individuals compared to drinkers who reported having a hangover. This finding suggests that the rate of ethanol metabolism is faster in drinkers who do not experience an alcohol hangover. This study aimed to directly compare alcohol metabolism after administering a low dose of ethanol to hangover sensitive drinkers and hangover resistant drinkers. METHODS: Social drinkers who previously participated in hangover trials at Utrecht University were invited to participate...
February 21, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29498416/workplace-lighting-for-improving-alertness-and-mood-in-daytime-workers
#16
REVIEW
Daniela V Pachito, Alan L Eckeli, Ahmed S Desouky, Mark A Corbett, Timo Partonen, Shantha Mw Rajaratnam, Rachel Riera
BACKGROUND: Exposure to light plays a crucial role in biological processes, influencing mood and alertness. Daytime workers may be exposed to insufficient or inappropriate light during daytime, leading to mood disturbances and decreases in levels of alertness. OBJECTIVES: To assess the effectiveness and safety of lighting interventions to improve alertness and mood in daytime workers. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, seven other databases; ClinicalTrials...
March 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29494867/exposure-to-interpersonal-violence-and-risk-of-post-traumatic-stress-disorder-among-women-with-borderline-personality-disorder
#17
Cave Sinai, Tatja Hirvikoski, Maria Wiklander, Anna-Lena Nordström, Peter Nordström, Åsa Nilsonne, Alexander Wilczek, Marie Åsberg, Jussi Jokinen
BACKGROUND: This study aims to determine the validity of the Karolinska Interpersonal Violence Scale (KIVS), as a screening tool for PTSD, among women with borderline personality disorder (BPD) and severe suicidal behavior. METHOD: 106 women with BPD and at least two suicide attempts were assessed with the KIVS for exposure to interpersonal violence as a child and as an adult. The screening ability of the KIVS for the diagnosis of PTSD was analyzed using receiver operating characteristic curve analysis...
February 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29483874/cardiac-autonomic-modulations-and-psychological-correlates-in-the-yukon-arctic-ultra-the-longest-and-the-coldest-ultramarathon
#18
Lea C Rundfeldt, Martina A Maggioni, Robert H Coker, Hanns-Christian Gunga, Alain Riveros-Rivera, Adriane Schalt, Mathias Steinach
Studies on human physical performance in extreme environments have effectively approached the investigation of adaptation mechanisms and their physiological limits. As scientific interest in the interplay between physiological and psychological aspects of performance is growing, we aimed to investigate cardiac autonomic control, by means of heart rate variability, and psychological correlates, in competitors of a subarctic ultramarathon, taking place over a 690 km course (temperatures between +5 and -47°C)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29482604/autoimmune-reactivity-to-malondialdehyde-adducts-in-systemic-lupus-erythematosus-is-associated-with-disease-activity-and-nephritis
#19
Uta Hardt, Anders Larsson, Iva Gunnarsson, Robert M Clancy, Michelle Petri, Jill P Buyon, Gregg J Silverman, Elisabet Svenungsson, Caroline Grönwall
BACKGROUND: Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increased in chronic inflammation and autoimmunity and may instead have pathogenic properties. METHODS: Herein, we investigated serum IgG anti-MDA levels by enzyme-linked immunosorbent assay (ELISA) in 398 systemic lupus erythematosus (SLE) patients in the Swedish Karolinska SLE cohort and compared these to findings in 225 US SLE patients from New York University and Johns Hopkins University...
February 26, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29448046/diurnal-variation-in-admission-troponin-concentrations-in-patients-with-chest-pain-in-the-emergency-department
#20
Andreas Roos, Martin J Holzmann
BACKGROUND: Recent studies have suggested that there may be large diurnal variation in cardiac troponin T (cTnT) concentrations measured with a high sensitive assay. OBJECTIVE: To investigate if clinically relevant diurnal variation in cTnT concentrations is present in patients with chest pain in the emergency department (ED). METHODS: We included all patients with chest pain, but no myocardial infarction (MI), and no other acute condition that may affect troponin concentrations in the ED at Karolinska University Hospital, Stockholm, Sweden, 2011-2014...
April 2018: Clinical Biochemistry
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