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https://www.readbyqxmd.com/read/29018406/editorial-karolinska-institutet-200-year-anniversary-symposium-on-injuries-to-the-spinal-cord-and-peripheral-nervous-system-an-update-on-recent-advances-in-regenerative-neuroscience
#1
EDITORIAL
https://www.readbyqxmd.com/read/28993921/-nanna-svartz-1890-1986-the-first-female-professor-of-medicine-in-sweden
#2
F A Wollheim
Nanna Svartz was a charismatic character who played a significant role in Swedish medicine in the mid-twentieth century. As one of five brothers and sisters, she escaped an early death from tuberculosis. She reached 96 years of age. Her diligence and sense of duty were legendary, along with her ambition to fully prove herself as "the first female professor". She inherited a certain insecurity from her father that led to her difficulty in taking criticism. Despite extensive academic obligations, she worked as a treating doctor for 55 years and always took her time with her patients, especially if they held important public positions...
October 9, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28987265/performance-and-sleepiness-in-nurses-working-12-h-day-shifts-or-night-shifts-in-a-community-hospital
#3
Marian Wilson, Regan Permito, Ashley English, Sandra Albritton, Carlana Coogle, Hans P A Van Dongen
Hospitals are around-the-clock operations and nurses are required to care for patients night and day. The nursing shortage and desire for a more balanced work-to-home life has popularized 12-h shifts for nurses. The present study investigated sleep/wake cycles and fatigue levels in 22 nurses working 12-h shifts, comparing day versus night shifts. Nurses (11day shift and 11 night shift) were recruited from a suburban acute-care medical center. Participants wore a wrist activity monitor and kept a diary to track their sleep/wake cycles for 2 weeks...
October 5, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28984492/prognostic-factors-affecting-survival-after-whole-brain-radiotherapy-in-patients-with-brain-metastasized-lung-cancer
#4
Georgios Tsakonas, Fatou Hellman, Michael Gubanski, Signe Friesland, Salomon Tendler, Rolf Lewensohn, Simon Ekman, Luigi de Petris
BACKGROUND: Whole-brain radiotherapy (WBRT) has been the standard of care for multiple NSCLC brain metastases but due to its toxicity and lack of survival benefit, its use in the palliative setting is being questioned. PATIENT AND METHODS: This was a single institution cohort study including brain metastasized lung cancer patients who received WBRT at Karolinska University Hospital. Information about Recursive Partitioning Analysis (RPA) and Graded Prognostic Assessment (GPA) scores, demographics, histopathological results and received oncological therapy were collected...
October 6, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28979835/a-comparison-of-best-practices-for-doctoral-training-in-europe-and-north-america
#5
Joey V Barnett, Robert A Harris, Michael J Mulvany
The PhD degree was established in Berlin 200 years ago and has since spread across the whole world. While there is general agreement that the degree is awarded in recognition of successfully completed research training, there have been significant differences in the way doctoral training programs have developed in particular countries. There is, however, a clear global tendency to follow the programs currently used either in the United States or in Europe. To determine more clearly how US and European PhD programs are both similar and different, we have used a validated questionnaire to analyze biomedical PhD programs in four representative institutions at Vanderbilt University, University of Manitoba, Karolinska Institutet, and Graz Medical University...
October 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28956513/the-medina-embolic-device-karolinska-experience
#6
P Bhogal, P A Brouwer, L Yeo, M Svensson, M Söderman
Background The aim of this study was to report our single centre experience with the Medina Embolic Device (MED). Methods We performed a retrospective analysis of prospectively collected data to identify all patients treated with the MED. A total of 14 aneurysms (non-consecutive), in 13 patients, were treated including one ruptured and one partially thrombosed aneurysm. Fundus diameter was ≥5 mm in all cases. We evaluated the angiographic appearances, the clinical status, complications, and the need for adjunctive devices or repeat treatments...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28956170/role-of-antithrombotic-therapy-in-the-risk-of-hematoma-recurrence-and-thromboembolism-after-chronic-subdural-hematoma-evacuation-a-population-based-consecutive-cohort-study
#7
Ida Fornebo, Kristin Sjåvik, Mark Alibeck, Helena Kristiansson, Fredrik Ståhl, Petter Förander, Asgeir Store Jakola, Jiri Bartek
OBJECTIVE: To establish the risk of recurrence in patients with chronic subdural hematoma (cSDH) on antithrombotic treatment (AT, i.e., antiplatelets and anticoagulants). Secondary end points were perioperative morbidity and mortality between groups (AT vs. no-AT group) and exploration if timing of resumption of AT treatment (i.e., prophylactic early vs. late resumption) influenced the occurrence of thromboembolism and hematoma recurrence. MATERIALS: In a population-based consecutive cohort, we conducted a retrospective review of 763 patients undergoing primary burr hole procedures for cSDH between January 1, 2005, and December 31, 2010, at the Karolinska University Hospital, Stockholm, Sweden...
September 27, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28951804/association-of-amplitude-and-stability-of-circadian-rhythm-sleep-quality-and-occupational-stress-with-sickness-absence-among-a-gas-company-employees-a-cross-sectional-study-from-iran
#8
Rezvan Zare, Alireza Choobineh, Sareh Keshavarzi
BACKGROUND: The present study was carried out to assess the relationship between sickness absence and occupational stress, sleep quality, and amplitude and stability of circadian rhythm as well as to determine contributing factors of sickness absence. METHODS: This cross sectional study was conducted on 400 randomly selected employees of an Iranian gas company. The data were collected using Pittsburgh sleep quality index, Karolinska sleepiness scale, circadian type inventory, and Osipow occupational stress questionnaires...
September 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28951075/first-episode-psychosis-patients-display-increased-plasma-il-18-that-correlates-with-cognitive-dysfunction
#9
Funda Orhan, Helena Fatouros-Bergman, Lilly Schwieler, Simon Cervenka, Lena Flyckt, Carl M Sellgren, Göran Engberg, Sophie Erhardt
No abstract text is available yet for this article.
September 23, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28886044/genetic-variants-in-cyp2b6-and-cyp2a6-explain-interindividual-variation-in-efavirenz-plasma-concentrations-of-hiv-infected-children-with-diverse-ethnic-origin
#10
Sandra Soeria-Atmadja, Emma Österberg, Lars L Gustafsson, Marja-Liisa Dahl, Jaran Eriksen, Johanna Rubin, Lars Navér
BACKGROUND: Approximately 2.6 million children live with HIV globally, and efavirenz (EFV) is one of the most widely used antiretroviral agents for HIV treatment in children and adults. There are concerns about the appropriateness of current EFV dosing and it has been discussed whether EFV dosing should be adapted according to genotype in children as suggested for adults. AIM: To investigate if pediatric EFV dosing should be guided by genetic variation in drug metabolizing enzymes rather than by body weight...
2017: PloS One
https://www.readbyqxmd.com/read/28879052/obesity-is-a-strong-predictor-of-worse-clinical-outcomes-and-treatment-responses-in-early-rheumatoid-arthritis-results-from-the-swefot-trial
#11
Adrian Levitsky, Kerstin Brismar, Ingiäld Hafström, Karen Hambardzumyan, Cecilia Lourdudoss, Ronald F van Vollenhoven, Saedis Saevarsdottir
OBJECTIVES: The aim of this paper was to analyse the impact of obesity, in addition to known predictors, on disease outcome in early rheumatoid arthritis (RA). METHODS: Body mass index (BMI) was available in 260 patients from the Swedish pharmacotherapy trial (SWEFOT). Differences in disease activity (DAS28), functional impairment (HAQ), pain (Visual Analogue Scale, VAS-pain) and radiographic damage were evaluated over 24 months between BMI categories (obese BMI >30, n=43; overweight BMI=25-29...
2017: RMD Open
https://www.readbyqxmd.com/read/28874298/survival-and-resource-utilization-in-patients-with-chest-pain-evaluated-with-cardiac-troponin-t-compared-with-high-sensitivity-cardiac-troponin-t
#12
Nadia Bandstein, Anna Wikman, Rickard Ljung, Martin J Holzmann
BACKGROUND: It is uncertain how the implementation of high-sensitivity cardiac troponin T (hs-cTnT) has affected the survival of patients with chest pain in the emergency department (ED). We studied prognosis and resource utilization in terms of coronary angiographies and revascularizations (percutaneous coronary intervention or coronary artery bypass grafting) in patients evaluated with hs-cTnT compared with conventional troponin T (cTnT). METHODS: All patients >25years presenting with chest pain and at least one troponin level analyzed in the ED at the Karolinska University Hospital, Sweden, were included...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28868186/salvage-gamma-knife-radiosurgery-in-the-management-of-dysembryoplastic-neuroepithelial-tumors-long-term-outcome-in-a-single-institution-case-series
#13
Georges Sinclair, Heather Martin, Alia Shamikh, Amir Samadi, Gerald Cooray, Jiri Bartek, Yehya Al-Saffar, Mikael Svensson, Ernest Dodoo
BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNT/DNET) are rare epileptogenic tumors. Microsurgery remains the best treatment option, although case reports exist on the use of gamma knife radiosurgery (GKRS) in selected cases. We investigated the long-term outcome of GKRS-treated DNTs at our institution in the context of current diagnostic and treatment options. CASE DESCRIPTIONS: We conducted a retrospective review of three consecutive adult patients (≥18 years) treated with salvage GKRS between 2002 and 2010 at Karolinska University Hospital, Stockholm, Sweden...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28867417/increased-psychiatric-morbidity-in-women-with-complete-androgen-insensitivity-syndrome-or-complete-gonadal-dysgenesis
#14
Hedvig Engberg, Anna Strandqvist, Anna Nordenström, Agnieszka Butwicka, Agneta Nordenskjöld, Angelica Lindén Hirschberg, Louise Frisén
OBJECTIVE: Knowledge concerning mental health outcomes is important to optimize the health of individuals with disorders or differences of sex development (DSD). Thus, the aim of this study was to estimate if the prevalence of psychiatric morbidity in adult women diagnosed with complete androgen insensitivity syndrome (CAIS) or complete gonadal dysgenesis (46,XY GD and 46,XX GD) differs from that in women with premature ovarian insufficiency (POI) or age-matched population controls. METHODS: This cross-sectional study was conducted at the Karolinska University Hospital, Stockholm, Sweden, and included 33 women with different DSDs: 20 CAIS, 6 46,XY GD, 7 46,XX GD, 21 women with POI and 61 population-derived controls...
August 8, 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28862959/hypo-attenuated-leaflet-thickening-and-reduced-leaflet-motion-in-sutureless-bioprosthetic-aortic-valves
#15
Magnus Dalén, Ulrik Sartipy, Kerstin Cederlund, Anders Franco-Cereceda, Anders Svensson, Raquel Themudo, Peter Svenarud, Elin Bacsovics Brolin
BACKGROUND: The prevalence of hypo-attenuated leaflet thickening (HALT) and reduced leaflet motion (RLM) is unknown in surgically implanted bioprostheses because systematic investigation of HALT and/or RLM is limited to a few catheter-based valves. The aim of this study was to investigate the prevalence of HALT and RLM by cardiac computed tomography in patients who underwent surgical aortic valve replacement and received a Perceval sutureless aortic valve bioprosthesis. METHODS AND RESULTS: This was a single-center prospective observational study that included 47 patients (83...
August 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28856478/sleep-duration-mortality-and-the-influence-of-age
#16
Torbjörn Åkerstedt, Francesca Ghilotti, Alessandra Grotta, Andrea Bellavia, Ylva Trolle Lagerros, Rino Bellocco
Prior work has shown that both short and long sleep predict mortality. However, sleep duration decreases with age and this may affect the relationship of sleep duration with mortality. The purpose of the present study was to assess whether the association between sleep duration and mortality varies with age. Prospective cohort study. 43,863 individuals (64% women), recruited in September 1997 during the Swedish National March and followed through record-linkages for 13 years. Sleep duration was self-reported and measured using the Karolinska Sleep Questionnaire, and grouped into 4 categories: ≤5, 6, 7 (reference) and ≥8 h...
August 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28845943/-laparoscopic-cystoprostatvesiculeectomy-with-orthotopic-excentric-ileal-bladder-substitution
#17
P V Glybochko, Yu G Alyaev, E V Shpot', A M Pshi-Khachev, K M Mosyakova, A S Nikolaeva
There are numerous options for forming an orthotopic bladder by the source tissue and the shape of the urinary reservoir. In our practice, we use the technique reported by Karolinska Institute (Sweden). This technique allows us to form a neobladder most resembling the natural urinary bladder in the shape and volume. The article presents a clinical observation describing this technique in a 63 year old patient who was initially diagnosed with bladder cancer pT2N0M0G3 and underwent transurethral resection of the bladder wall with the tumor...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28833754/trait-impulsiveness-is-related-to-smaller-post-commissural-putamen-volumes-in-males-but-not-females
#18
Fernando Caravaggio, Eric Plitman, Jun Ku Chung, Philip Gerretsen, Julia Kim, Yusuke Iwata, Mallar Chakravarty, Gary Remington, Ariel Graff-Guerrero
Impulsivity is considered a vulnerability trait for addiction. Recently, we found trait non-planning impulsiveness measured with the Karolinska Scales of Personality was negatively correlated with dopamine D2/3 receptor availability in the ventral striatum of healthy humans. While also observed in rodents, human studies have failed to find this association with other measures of trait impulsivity. We explored whether another rodent finding, reduced ventral striatum volume with greater impulsivity, could also be observed in humans using this scale...
October 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28829792/effect-of-endurance-exercise-on-micrornas-in-myositis-skeletal-muscle-a-randomized-controlled-study
#19
Jessica F Boehler, Marshall W Hogarth, Matthew D Barberio, James S Novak, Svetlana Ghimbovschi, Kristy J Brown, Li Alemo Munters, Ingela Loell, Yi-Wen Chen, Heather Gordish-Dressman, Helene Alexanderson, Ingrid E Lundberg, Kanneboyina Nagaraju
OBJECTIVE: To identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis (PM) and dermatomyositis (DM) patients. METHODS: Following a parallel clinical trial design, patients with probable PM or DM, exercising less than once a week, and on stable medication for at least one month were randomized into two groups at Karolinska University Hospital: a 12-week endurance exercise group (n = 12) or a non-exercised control group (n = 11)...
2017: PloS One
https://www.readbyqxmd.com/read/28812454/risk-factors-for-intrapartum-acidemia-a-cohort-study
#20
Stina Wretler, Lennart Nordström, Sophie Graner, Malin Holzmann
PURPOSE: Birth acidemia is associated with short- and long-term morbidity in the child. Optimal intrapartum surveillance and timely interventions may reduce the incidence of these outcomes. Knowledge about conditions which increase the risks might be beneficial for optimal care. The aim with this study was to identify factors which increased the risk for lactacidemia in fetal scalp blood. MATERIALS AND METHODS: A secondary analysis of a cohort study performed at Karolinska University Hospital Stockholm Sweden between February 2009 and February 2011...
August 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
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