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https://www.readbyqxmd.com/read/29448046/diurnal-variation-in-admission-troponin-concentrations-in-patients-with-chest-pain-in-the-emergency-department
#1
Andreas Roos, Martin J Holzmann
BACKGROUND: Recent studies have suggested that there may be large diurnal variation in cardiac troponin T (cTnT) concentrations measured with a high sensitive assay. OBJECTIVE: To investigate if clinically relevant diurnal variation in cTnT concentrations is present in patients with chest pain in the emergency department (ED). METHODS: We included all patients with chest pain, but no myocardial infarction (MI), and no other acute condition that may affect troponin concentrations in the ED at Karolinska University Hospital, Stockholm, Sweden, 2011-2014...
February 12, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29444712/physical-activity-as-treatment-for-alcohol-use-disorders-fitforchange-study-protocol-for-a-randomized-controlled-trial
#2
Mats Hallgren, Victoria Andersson, Örjan Ekblom, Sven Andréasson
BACKGROUND: Help-seeking for alcohol use disorders (AUDs) is low and traditional treatments are often perceived as stigmatizing. Physical activity has positive effects on mental and physical health which could benefit this population. We propose to compare the effects of aerobic training, yoga, and usual care for AUDs in physically inactive Swedish adults. METHODS: This is a three-group, parallel, single-blind, randomized controlled trial (RCT). In total, 210 adults (aged 18-75 years) diagnosed with an AUD will be invited to participate in a 12-week intervention...
February 14, 2018: Trials
https://www.readbyqxmd.com/read/29435627/wide-surgical-margin-improves-the-outcome-for-patients-with-gastrointestinal-stromal-tumors-gists
#3
Jan Åhlén, Fredrik Karlsson, Johan Wejde, Inga-Lena Nilsson, Catharina Larsson, Robert Bränström
BACKGROUND: Surgical resection is still the main treatment for gastrointestinal stromal tumor (GIST), and R0 excision, regardless of surgical margins, is considered sufficient. METHODS: A cohort of 79 consecutive GIST cases treated at the Karolinska University Hospital, who were without metastasis at diagnosis and who had not received any pre-or postoperative treatment with tyrosine kinase inhibitors, was included. Surgical margins were evaluated at the time of surgery and classified as wide, marginal or intralesional...
February 12, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29432370/experiences-of-a-one-hour-algorithm-in-chest-pain-patients-with-a-nonelevated-troponin-t-at-presentation
#4
Anna Pettersson, Lina Ljung, Caroline Johansson, Umut Heilborn, Tomas Jernberg, Mats Frick, Kai M Eggers, Bertil Lindahl, Rikard Linder, Arne Martinsson, Per Svensson
BACKGROUND: We aimed to evaluate the use of a 1-hour measurement of high-sensitivity cardiac troponin T (hs-cTnT) in an emergency department (ED) population of chest pain patients with a nonelevated baseline hs-cTnT and to examine the prevalence of early dynamic changes in hs-cTnT and the association with admission rate, diagnosis, and outcome. METHODS: All patients with a chief complaint of chest pain presenting to the ED of Karolinska University Hospital, Solna, Sweden, from December 2014 to September 2015 who had a baseline hs-cTnT of ≤14 ng/L and a second value obtained within >30 to ≤90 minutes were followed for 30 days regarding admission, readmission, myocardial infarction (MI), and death...
March 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29430747/left-atrial-rather-than-left-ventricular-impaired-mechanics-are-associated-with-the-pro-fibrotic-st2-marker-and-outcomes-in-heart-failure-with-preserved-ejection-fraction
#5
A I Nagy, C Hage, B Merkely, E Donal, J-C Daubert, C Linde, L H Lund, A Manouras
AIMS: Left ventricular (LV) mechanics have been extensively investigated in heart failure with preserved ejection fraction (HFpEF) overshadowing for a long time the potential role of left atrium (LA) in that setting. Soluble suppression of tumorigenicity-2 receptor (ST2) is a novel biomarker of pro-fibrotic burden in HF. We hypothesized that due to the thinner LA wall, the fibrotic myocardial changes in HFpEF as indicated by elevated ST2 levels might more readily be reflected by impairments in the LA rather than the LV performance...
February 12, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29406590/cirrhosis-high-age-and-high-body-mass-index-are-risk-factors-for-persisting-advanced-fibrosis-after-sustained-virologic-response-in-chronic-hepatitis-c
#6
Magnus Hedenstierna, Ali Nangarhari, Amin El-Sabini, Ola Weiland, Soo Aleman
We aimed to assess fibrosis with liver stiffness measurement long-term after sustained virologic response of chronic hepatitis C, and to identify risk factors associated with persisting fibrosis. In this cross-sectional study, patients with chronic hepatitis C and pre-treatment advanced fibrosis or cirrhosis treated successfully at Karolinska University Hospital with an interferon-containing regimen, underwent liver stiffness measurement with FibroScan. The impact of potential risk factors for persisting fibrosis was estimated...
February 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29402554/corrigendum-to-long-term-mortality-and-morbidity-among-30-day-survivors-after-in-hospital-cardiac-arrests-a-swedish-cohort-study-resuscitation-124-2018-76-79
#7
Mahta Memar, Sammy-Jo Geara, Patrik Hjalmarsson, Anna Allberg, Mathilde Bouzereau, Therese Djärv
OBJECTIVES: Resuscitation on in-hospital cardiac arrest (IHCA) is estimated to occur in 200,000 hospitalised patients annually in the US and short-term survival, i.e. 30 days, is reported to be around 15-20%. Even if 30-day survival is a good measure of successful resuscitation, the number of survivors is quite high and a perspective on longer-term outcomes is relevant. AIM: To assess long-term mortality among 30-day survivors after an IHCA. MATERIAL AND METHODS: All patients ≥18 years surviving for at least 30 days after an IHCA at Karolinska University Hospital between 1st January 2007 and 31st December 2014 were included...
February 2, 2018: Resuscitation
https://www.readbyqxmd.com/read/29402400/how-much-is-left-in-your-sleep-tank-proof-of-concept-for-a-simple-model-for-sleep-history-feedback
#8
Jillian Dorrian, Steven Hursh, Lauren Waggoner, Crystal Grant, Maja Pajcin, Charlotte Gupta, Alison Coates, David Kennaway, Gary Wittert, Leonie Heilbronn, Chris Della Vedova, Siobhan Banks
Technology-supported methods for sleep recording are becoming increasingly affordable. Sleep history feedback may help with fatigue-related decision making - Should I drive? Am I fit for work? This study examines a "sleep tank" model (SleepTank™), which is analogous to the fuel tank in a car, refilled by sleep, and depleted during wake. Required inputs are sleep period time and sleep efficiency (provided by many consumer-grade actigraphs). Outputs include suggested hours remaining to "get sleep" and percentage remaining in tank (Tank%)...
February 2, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29396773/dolutegravir-in-pregnancy-effects-on-hiv-positive-women-and-their-infants
#9
Riikka Bornhede, Sandra Soeria-Atmadja, Katarina Westling, Karin Pettersson, Lars Navér
The development of new drugs for treatment of HIV has increased the efficacy and the quality of life together with decreased unwanted side-effect for people living with HIV. The integrase inhibitor dolutegravir has in short time become part of the first-line treatment in many countries, but is not a recommended first-line drug in pregnancy. As there are few publications of dolutegravir use during pregnancy, we found it valuable to analyze the Stockholm pregnancy cohort. A retrospective analysis of all pregnant women and their infants exposed to dolutegravir at Karolinska University Hospital, 2014-August 2017...
February 2, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29392371/effect-of-intranasal-esketamine-on-cognitive-functioning-in-healthy-participants-a-randomized-double-blind-placebo-controlled-study
#10
Randall L Morrison, Maggie Fedgchin, Jaskaran Singh, Joop Van Gerven, Rob Zuiker, Kyoung Soo Lim, Peter van der Ark, Ewa Wajs, Liwen Xi, Peter Zannikos, Wayne C Drevets
BACKGROUND: The effect of intranasal esketamine on cognitive functioning in healthy participants is assessed in this study. METHODS: Twenty-four participants (19-49 years) were randomized to one of two treatment sequences in which either esketamine 84 mg or placebo was intranasally administered in a double-blind, two-period crossover design. Primary measures included five tests of Cogstate® computerized test battery assessed at 1 h predose and 40 min, 2, 4, and 6 h postdose...
February 1, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29380231/riedel-s-thyroiditis-clinical-presentation-treatment-and-outcomes
#11
Henrik Falhammar, Carl Christofer Juhlin, Caroline Barner, Sergiu-Bogdan Catrina, Christos Karefylakis, Jan Calissendorff
BACKGROUND: Riedel´s thyroiditis (RT) is a rare inflammatory disease of the thyroid gland, causing compression and fibrosis of adjacent tissues. Typically the goiter is hard and firm. Hoarseness, dyspnea, and dysphagia may be present. METHODS: We retrospectively reviewed all patients known by us with RT in addition to all patients with appropriate ICD-10 codes evaluated at the Karolinska University Hospital 2003-2015. Clinical, biochemical, and histological data of patients with RT were recorded in detail...
January 29, 2018: Endocrine
https://www.readbyqxmd.com/read/29369188/human-cytomegalovirus-in-high-grade-serous-ovarian-cancer-possible-implications-for-patients-survival
#12
Joseph W Carlson, Angelique Flöter Rådestad, Cecilia Söderberg-Naucler, Afsar Rahbar
Patients diagnosed with high grade serous ovarian adenocarcinoma have a poor prognosis. Recently human cytomegalovirus (HCMV) has been detected in several tumors. Here, we evaluated HCMV in ovarian cancer tissue specimens obtained at pre- and postchemotherapy tumor resection.Available paraffin embedded ovarian cancer tissues from matched pre- and postchemotherapy tumor resection specimens (i.e., diagnostic excisional biopsy prechemotherapy; DEBPC) and neoadjuvant chemotherapy followed by interval debulking surgery (NACT + IDS) from 10 patients with stage IIIC-IV high grade serous ovarian carcinoma (HGS) diagnosed between years 2007 and 2008 at Karolinska University Hospital were examined for HCMV immediate-early protein (HCMV-IE), tegument protein pp65, and nucleic acid (β2...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29361985/inherited-factors-contribute-to-an-inverse-association-between-preeclampsia-and-breast-cancer
#13
Haomin Yang, Wei He, Mikael Eriksson, Jingmei Li, Natalie Holowko, Flaminia Chiesa, Per Hall, Kamila Czene
BACKGROUND: Preeclampsia is frequently linked to reduced breast cancer risk. However, little is known regarding the underlying genetic association and the association between preeclampsia and mammographic density. METHODS: This study estimates the incidence rate ratios (IRRs) of breast cancer in patients with preeclampsia, when compared to women without preeclampsia, using Poisson regression models in two cohorts of pregnant women: a Swedish nationwide cohort (n = 1,337,934, 1973-2011) and the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA, n = 55,044, 1958-2015)...
January 23, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29359843/norovirus-causingsevere-gastrointestinal-disease-following-allogeneic-hematopoietic-stem-cell-transplantation-a-retrospective-analysis
#14
Lisa Swartling, Per Ljungman, Mats Remberger, Mikael Sundin, Annika Tiveljung, Jonas Mattsson, Elda Sparrelid
BACKGROUND: Norovirus (NV) can cause chronic and severe gastroenteritis with possible lethal outcome in immunocompromised patients. The knowledge of NV infections in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is limited. The aim of this study was to clarify the clinical importance of NV in a large cohort of HSCT recipients. METHODS: All patients undergoing HSCT and diagnosed with NV at Karolinska University Hospital 2006-2012 were included in the study (63 patients)...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29358448/investigating-the-application-of-motion-accelerometers-as-a-sleep-monitoring-technique-and-the-clinical-burden-of-the-intensive-care-environment-on-sleep-quality-study-protocol-for-a-prospective-observational-study-in-australia
#15
Lori J Delaney, Marian J Currie, Hsin-Chia Carol Huang, Edward Litton, Bradley Wibrow, Violeta Lopez, Frank Van Haren
INTRODUCTION: Sleep is a state of quiescence that facilitates the significant restorative processes that enhance individuals' physiological and psychological well-being. Patients admitted to the intensive care unit (ICU) experience substantial sleep disturbance. Despite the biological importance of sleep, sleep monitoring does not form part of standard clinical care for critically ill patients. There exists an unmet need to assess the feasibility and accuracy of a range of sleep assessment techniques that have the potential to allow widespread implementation of sleep monitoring in the ICU...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29346796/background-factors-and-subjective-voice-symptoms-in-patients-with-acquired-vocal-fold-scarring-and-sulcus-vocalis
#16
Emma Malmström, Stellan Hertegård
OBJECTIVE: Vocal fold scarring (VFS) and sulcus vocalis (SV) often result in severe and chronic voice disorders. This study compares subjective voice complaints as rated with the Voice Handicap Index and etiological factors for patients with VFS and SV. PATIENTS AND METHODS: Data were collected from the medical records at the Department of Otorhinolaryngology, Karolinska University Hospital, for 27 VFS patients and 27 SV patients. Descriptive background factors were compared between the groups and data were compared from the Swedish Voice Handicap Index (Sw-VHI) questionnaires...
January 18, 2018: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29340154/the-impact-of-sepsis-delirium-and-psychological-distress-on-self-rated-cognitive-function-in-icu-survivors-a-prospective-cohort-study
#17
Emily Brück, Anna Schandl, Matteo Bottai, Peter Sackey
Background: Many intensive care unit (ICU) survivors develop psychological problems and cognitive impairment. The relation between sepsis, delirium, and later cognitive problems is not fully elucidated, and the impact of psychological symptoms on cognitive function is poorly studied in ICU survivors. The primary aim of this study was to examine the relationship between sepsis, ICU delirium, and later self-rated cognitive function. A second aim was to investigate the association between psychological problems and self-rated cognitive function 3 months after the ICU stay...
2018: Journal of Intensive Care
https://www.readbyqxmd.com/read/29335713/risk-for-arterial-and-venous-thrombosis-in-patients-with-myeloproliferative-neoplasms-a-population-based-cohort-study
#18
Malin Hultcrantz, Magnus Björkholm, Paul W Dickman, Ola Landgren, Åsa R Derolf, Sigurdur Y Kristinsson, Therese M L Andersson
Background: Patients with myeloproliferative neoplasms (MPNs) are reported to be at increased risk for thrombotic events. However, no population-based study has estimated this excess risk compared with matched control participants. Objective: To assess risk for arterial and venous thrombosis in patients with MPNs compared with matched control participants. Design: Matched cohort study. Setting: Population-based setting in Sweden from 1987 to 2009, with follow-up to 2010...
January 16, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29327143/long-term-control-and-predictors-of-seizures-in-intracranial-meningioma-surgery-a-population-based-study
#19
Hai Xue, Olafur Sveinsson, Jiri Bartek, Petter Förander, Simon Skyrman, Lars Kihlström, Raana Shafiei, Tiit Mathiesen, Torbjörn Tomson
BACKGROUND: The aim of this retrospective study was to investigate the long-term seizure control and antiepileptic drug (AED) prescriptions, as well as identifying predictors of seizure(s) before and after surgery in a population-based cohort of operated intracranial meningioma patients. METHODS: A total of 113 consecutive adult (> 18 years old) patients with newly diagnosed meningioma operated at the Karolinska University Hospital between 2006 and 2008 were included and followed up until the end of 2015...
January 11, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29325109/estimating-adolescent-sleep-need-using-dose-response-modelling
#20
Michelle A Short, Nathan Weber, Chelsea Reynolds, Scott Coussens, Mary A Carskadon
Study Objectives: This study will, (a) estimate the nightly sleep need of human adolescents, (b) determine the time course and severity of sleep-related deficits when sleep is reduced below this optimal quantity, and (c) determine whether sleep restriction perturbs the circadian system as well as the sleep homeostat. Methods: Thirty-four adolescents aged 15 to 17 years spent 10 days and 9 nights in the sleep laboratory. Between two baseline nights and two recovery nights with 10-hours' time in bed (TIB) per night, participants experienced either severe sleep restriction (5-hr TIB), moderate sleep restriction (7...
January 6, 2018: Sleep
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