keyword
MENU ▼
Read by QxMD icon Read
search

Karolinska

keyword
https://www.readbyqxmd.com/read/28329124/sleep-and-alertness-in-medical-interns-and-residents-an-observational-study-on-the-role-of-extended-shifts
#1
Mathias Basner, David F Dinges, Judy A Shea, Dylan S Small, Jingsan Zhu, Laurie Norton, Adrian J Ecker, Cristina Novak, Lisa M Bellini, Kevin G Volpp
Study Objectives: Fatigue from sleep loss is a risk to physician and patient safety, but objective data on physician sleep and alertness on different duty hour schedules is scarce. This study objectively quantified differences in sleep duration and alertness between medical interns working extended overnight shifts and residents not or rarely working extended overnight shifts. Methods: Sleep-wake activity of 137 interns and 87 PGY-2/3 residents on 2-week Internal Medicine and Oncology rotations was assessed with wrist-actigraphy...
February 24, 2017: Sleep
https://www.readbyqxmd.com/read/28325735/rescue-preoperative-treatment-with-lugol-s-solution-in-uncontrolled-graves-disease
#2
Jan Calissendorff, Henrik Falhammar
BACKGROUND: Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium-iodide to induce euthyroidism before surgery could be advocated but has rarely been reported. METHOD: All patients hospitalised due to uncontrolled hyperthyroidism at the Karolinska University Hospital 2005-2015 and treated with Lugol's solution were included...
March 21, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28322821/genetics-of-the-hypoxia-inducible-factors-in-human-cancers
#3
Keiji Tanimoto
Professor Lorenz Poellinger (Karolinska Institute/Cancer Science Institute of Singapore) passed away in March 2016. Then hypoxic research field lost a noble and unique researcher when he died, since he had contributed very much to this field in a variety of aspects. We had been collaborating on a various research projects of genomic analyses of HIF-signaling pathway for a long time, and recently reported several interesting results with HIF-α genes (HIF1A, EPAS1 and HIF3A). Genomics/Genetics is a still growing field, with new technologies appearing often, and many groups have performed extensive genomic/genetic analyses...
March 17, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28318305/on-demand-driver-vigilance-enhancement-without-explicit-drowsiness-detection-further-analysis-of-the-pilot-study-results
#4
R Michael Van Auken, Brad K Hagoski, Dean P Chiang, Shane Chang
OBJECTIVE: A new active safety concept that engages the driver's psychosensory pain-processing mechanism to automatically trigger vigilance enhancement on-demand was proposed in Chang ( 2012 ). This concept is based on the hypothesis that a human's pain threshold will decline as he/she becomes drowsy, consequently triggering the vigilance enhancer. The objective of this pilot study was to develop methods to test this hypothesis, the results of which could lead to further refinement of the hypothesis and methods, with the ultimate goal of developing new active safety concepts that exploit the driver's endogenous psychosensory pain-processing mechanisms...
March 20, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28304205/stenting-of-the-cervical-internal-carotid-artery-in-acute-stroke-management-the-karolinska-experience
#5
Anastasios Mpotsaris, Christoph Kabbasch, Jan Borggrefe, Vamsi Gontu, Michael Soderman
Background Emergency stent placement in the extracranial internal carotid artery in combination with anterior circulation thrombectomy is a routine procedure. Yet, precise indications and clinical safety in this setting remains controversial. Present data for mechanical thrombectomy include few studies with acute stenting of tandem occlusions. We evaluated the feasibility, safety and clinical outcome of this endovascular treatment in a retrospective analysis of all consecutive cases at a comprehensive stroke centre...
April 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28300964/effects-of-a-12-hour-shift-on-mood-states-and-sleepiness-of-neonatal-intensive-care-unit-nurses
#6
Tadeu Sartini Ferreira, Clarice Zinato Moreira, James Guo, Franco Noce
OBJECTIVE: To assess the effect of a 12-hour shift on mood states and sleepiness at the beginning and end of the shift. METHOD: Quantitative, cross-sectional and descriptive study.It was conducted with 70 neonatal intensive care unit nurses. The Brunel Mood Scale (BRUMS), Karolinska Sleepiness Scale (KSS), and a socio-demographic profile questionnaire were administered. RESULTS: When the KSS and BRUMS scores were compared at the beginning of the shift associations were found with previous sleep quality (p ≤ 0...
March 9, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28289277/csf-gaba-is-reduced-in-first-episode-psychosis-and-associates-to-symptom-severity
#7
F Orhan, H Fatouros-Bergman, M Goiny, A Malmqvist, F Piehl, S Cervenka, K Collste, P Victorsson, C M Sellgren, L Flyckt, S Erhardt, G Engberg
Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains of mental function. γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and is increasingly recognized to have a significant role in the pathophysiology of the disorder. In the present study, cerebrospinal fluid (CSF) concentrations of GABA were analyzed in 41 first-episode psychosis (FEP) patients and 21 age- and sex-matched healthy volunteers by high-performance liquid chromatography...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28274206/the-h-o-u-s-e-classification-a-novel-endoscopic-retrograde-cholangiopancreatography-ercp-complexity-grading-scale
#8
Greger Olsson, Urban Arnelo, Fredrik Swahn, Björn Törnqvist, Lars Lundell, Lars Enochsson
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is a technically challenging endoscopic procedure, harboring a wide range of complexities within every single investigation. Classifications of the complexity of ERCP have been presented, but do not include modern endoscopic treatment modalities. In order to be able to target resources and compare the results of different endoscopic centers, a new complexity grading system for ERCP is warranted. This study launches a new complexity grading scale for ERCP-the H...
March 9, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28259894/night-shift-work-is-associated-with-increased-pain-perception
#9
Dagfinn Matre, Stein Knardahl, Kristian Bernhard Nilsen
Objectives The aim of the present study was to determine whether shift workers exhibit increased perception of experimentally induced pain after working night shifts. Methods The study was a paired cross-over design with two sleep conditions, after at least two nights of habitual sleep and after two consecutive night shifts at work. Fifty-three nurses in rotating shift work participated. The sensitivity to electrically induced pain, heat pain, cold pain, pressure pain and pain inhibition was determined experimentally in each sleep condition...
March 5, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28257459/predictive-value-of-traction-force-measurement-in-vacuum-extraction-development-of-a-multivariate-prognostic-model
#10
Kristina Pettersson, Khurram Yousaf, Jonas Ranstam, Magnus Westgren, Gunilla Ajne
OBJECTIVE: To enable early prediction of strong traction force vacuum extraction. DESIGN: Observational cohort. SETTING: Karolinska University Hospital delivery ward, tertiary unit. POPULATION AND SAMPLE SIZE: Term mid and low metal cup vacuum extraction deliveries June 2012-February 2015, n = 277. METHODS: Traction forces during vacuum extraction were collected prospectively using an intelligent handle...
2017: PloS One
https://www.readbyqxmd.com/read/28210554/preoperative-psychosocial-characteristics-may-predict-body-image-and-sexuality-two-years-after-risk-reducing-mastectomy-a-prospective-study
#11
Dmytro Unukovych, Hemming Johansson, Yvonne Brandberg
BACKGROUND: Risk-reducing mastectomy (RRM) in patients at high risk has become more available and the rates of both bilateral (BRRM) and contralateral (CRRM) procedures are increasing. For women opting for RRM, psychosocial well-being, body image and sexuality are known to be important patient-reported outcomes. The aim of the present study was to investigate baseline health-related quality of life (HRQoL) and emotional distress (anxiety and depression) as predictors of body image and sexuality two years after RRM in women undergoing CRRM and BRRM...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28194003/lower-levels-of-the-glial-cell-marker-tspo-in-drug-naive-first-episode-psychosis-patients-as-measured-using-pet-and-11-c-pbr28
#12
K Collste, P Plavén-Sigray, H Fatouros-Bergman, P Victorsson, M Schain, A Forsberg, N Amini, S Aeinehband, S Erhardt, C Halldin, L Flyckt, L Farde, S Cervenka
Several lines of evidence are indicative of a role for immune activation in the pathophysiology of schizophrenia. Nevertheless, studies using positron emission tomography (PET) and radioligands for the translocator protein (TSPO), a marker for glial activation, have yielded inconsistent results. Whereas early studies using a radioligand with low signal-to-noise in small samples showed increases in patients, more recent studies with improved methodology have shown no differences or trend-level decreases. Importantly, all patients investigated thus far have been on antipsychotic medication, and as these compounds may dampen immune cell activity, this factor limits the conclusions that can be drawn...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28180256/cohort-profile-the-karolinska-mammography-project-for-risk-prediction-of-breast-cancer-karma
#13
Marike Gabrielson, Mikael Eriksson, Mattias Hammarström, Signe Borgquist, Karin Leifland, Kamila Czene, Per Hall
No abstract text is available yet for this article.
February 9, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28169930/in-hospital-surgical-delay-does-not-increase-the-risk-for-perforated-appendicitis-in-children-a-single-center-retrospective-cohort-study
#14
Markus Almström, Jan F Svensson, Barbora Patkova, Anna Svenningsson, Tomas Wester
OBJECTIVE: To investigate the correlation between in-hospital surgical delay before appendectomy for suspected appendicitis and the finding of perforated appendicitis in children. METHODS: All children undergoing acute appendectomy for suspected acute appendicitis at Karolinska University Hospital, Stockholm, Sweden from 2006 to 2013 were reviewed for the exposure of surgical delay. Primary endpoint was the histopathologic finding of perforated appendicitis. The main explanatory variable was in-hospital surgical delay, using surgery within 12 hours as reference...
March 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28166895/effects-of-vibration-on-occupant-driving-performance-under-simulated-driving-conditions
#15
Amzar Azizan, M Fard, Michael F Azari, Reza Jazar
Although much research has been devoted to the characterization of the effects of whole-body vibration on seated occupants' comfort, drowsiness induced by vibration has received less attention to date. There are also little validated measurement methods available to quantify whole body vibration-induced drowsiness. Here, the effects of vibration on drowsiness were investigated. Twenty male volunteers were recruited for this experiment. Drowsiness was measured in a driving simulator, before and after 30-min exposure to vibration...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28144582/reliability-and-concurrent-validity-of-postural-asymmetry-measurement-in-adolescent-idiopathic-scoliosis
#16
Ashleigh Prowse, Berit Aslaksen, Marie Kierkegaard, James Furness, Paul Gerdhem, Allan Abbott
AIM: To investigate the reliability and concurrent validity of the Baseline(®) Body Level/Scoliosis meter for adolescent idiopathic scoliosis postural assessment in three anatomical planes. METHODS: This is an observational reliability and concurrent validity study of adolescent referrals to the Orthopaedic department for scoliosis screening at Karolinska University Hospital, Stockholm, Sweden between March-May 2012. A total of 31 adolescents with idiopathic scoliosis (13...
January 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28123662/sleep-restriction-may-lead-to-disruption-in-physiological-attention-and-reaction-time
#17
Arbind Kumar Choudhary, Sadawarte Sahebrao Kishanrao, Anup Kumar Dadarao Dhanvijay, Tanwir Alam
Sleepiness is the condition where for some reason fails to go into a sleep state and will have difficulty in remaining awake even while carrying out activities. Sleep restriction occurs when an individual fails to get enough sleep due to high work demands. The mechanism between sleep restriction and underlying brain physiology deficits is not well assumed. The objective of the present study was to investigate the mental attention (P300) and reaction time [visual (VRT) and auditory (ART)] among night watchmen, at subsequent; first (1st) day, fourth (4th) day and seventh (7th) day of restricted sleep period...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28112598/acute-effects-of-glossopharyngeal-insufflation-in-people-with-cervical-spinal-cord-injury
#18
Malin Nygren-Bonnier, Tomas A Schiffer, Peter Lindholm
OBJECTIVES: To evaluate acute effects of glossopharyngeal insufflation (GI) on lung function, airway pressure (Paw), blood pressure and heart rate (HR) in people with cervical spinal cord injury (CSCI). DESIGN: Case-control design. SETTING: Karolinska Institutet, Stockholm, Sweden. PARTICIPANTS: Ten participants with CSCI suffering from lesions between C4 and C8, and ASIA classification of A or B were recruited. Ten healthy particpants familiar with GI were recruited as a reference group...
January 23, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28100627/inflammatory-biomarkers-predict-heart-failure-severity-and-prognosis-in-patients-with-heart-failure-with-preserved-ejection-fraction-a-holistic-proteomic-approach
#19
Camilla Hage, Erik Michaëlsson, Cecilia Linde, Erwan Donal, Jean-Claude Daubert, Li-Ming Gan, Lars H Lund
BACKGROUND: Underlying mechanisms in heart failure (HF) with preserved ejection fraction remain unknown. We investigated cardiovascular plasma biomarkers in HF with preserved ejection fraction and their correlation to diastolic dysfunction, functional class, pathophysiological processes, and prognosis. METHODS AND RESULTS: In 86 stable patients with HF and EF ≥45% in the Karolinska Rennes (KaRen) biomarker substudy, biomarkers were quantified by a multiplex immunoassay...
February 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28098624/long-term-survival-in-adults-treated-with-extracorporeal-membrane-oxygenation-for-respiratory-failure-and-sepsis
#20
Viktor von Bahr, Jan Hultman, Staffan Eksborg, Björn Frenckner, Håkan Kalzén
OBJECTIVE: The use of extracorporeal membrane oxygenation in adults with respiratory failure and sepsis is steadily increasing, but the knowledge on long-term survival in this group is scarce. The aim of the present study was to investigate the 5-year survival rates and causes of late death in this group of patients. DESIGN: Single-center retrospective cohort study. SETTING: Karolinska University Hospital, Stockholm, Sweden. PATIENTS: Adult patients treated with extracorporeal membrane oxygenation for respiratory failure and sepsis between the service being established for adults in 1995 and December 2013...
February 2017: Critical Care Medicine
keyword
keyword
72773
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"