keyword
https://read.qxmd.com/read/38526767/a-comparison-of-clear-cell-sarcoma-to-jaw-and-salivary-tumors-bearing-ews-fusions
#1
REVIEW
Ornela Xhori, Navkiran Deol, Camron M Rivera, Jason Zavras, Sophia G Weil, Hirad Zafari, Julia C Thierauf, William C Faquin, Edwin Choy, Miguel N Rivera, A John Iafrate, Alexandre Jaquinet, Maria J Troulis
OBJECTIVE: To review tumors identified as "clear cell sarcoma" in order to determine similarities to the rare EWS fusion positive jaw and salivary gland tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma of the salivary gland (CCC). METHODS: PubMed was used to collect all reports of clear cell sarcoma (CCS). Search parameters were "clear cell sarcoma" and "CCS." References in the publications were screened and cross-referenced. Data extracted included demographic characteristics, presenting signs and symptoms, radiographic findings, histological and immunohistochemical features and known molecular/genetic aberrations...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38496628/ongoing-evolution-of-sars-cov-2-drives-escape-from-mrna-vaccine-induced-humoral-immunity
#2
Alex L Roederer, Yi Cao, Kerri St Denis, Maegan L Sheehan, Chia Jung Li, Evan C Lam, David J Gregory, Mark C Poznansky, A John Iafrate, David H Canaday, Stefan Gravenstein, Wilfredo F Garcia-Beltran, Alejandro B Balazs
Since the COVID-19 pandemic began in 2020, viral sequencing has documented 131 individual mutations in the viral spike protein across 48 named variants. To determine the ability of vaccine-mediated humoral immunity to keep pace with continued SARS-CoV-2 evolution, we assessed the neutralization potency of sera from 76 vaccine recipients collected after 2 to 6 immunizations against a comprehensive panel of mutations observed during the pandemic. Remarkably, while many individual mutations that emerged between 2020 and 2022 exhibit escape from sera following primary vaccination, few escape boosted sera...
March 7, 2024: medRxiv
https://read.qxmd.com/read/38467872/fishing-for-the-evidence-on-community-water-fluoridation-a-commentary-on-the-catfish-study
#3
JOURNAL ARTICLE
Lorenzo Iafrate, Declan Cairns, Morag Muir
DATA SOURCE: Goodwin M, Emsley R, Kelly M P et al. Evaluation of water fluoridation scheme in Cumbria: the CATFISH prospective longitudinal cohort study. Southampton: National Institute for Health and Care Research, 2022. METHODS: This longitudinal, prospective cohort study, recruited two populations - a birth cohort and older school cohort - assessing the effects of community water fluoridation (CWF) over a five-year period. The control group received non-fluoridated drinking water in the East of Cumbria, while the intervention group received fluoridated drinking water in the West of Cumbria...
March 11, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38328243/blood-based-screening-for-hpv-associated-cancers
#4
Dipon Das, Shun Hirayama, Ling Aye, Michael E Bryan, Saskia Naegele, Brian Zhao, Vasileios Efthymiou, Julia Mendel, Adam S Fisch, Lea Kröller, Birgitta E Michels, Tim Waterboer, Jeremy D Richmon, Viktor Adalsteinsson, Michael S Lawrence, Matthew G Crowson, A John Iafrate, Daniel L Faden
BACKGROUND: HPV-associated oropharyngeal cancer (HPV+OPSCC) is the most common HPV-associated cancer in the United States yet unlike cervical cancer lacks a screening test. HPV+OPSCCs are presumed to start developing 10-15 years prior to clinical diagnosis. Circulating tumor HPV DNA (ctHPVDNA) is a sensitive and specific biomarker for HPV+OPSCC. Taken together, blood-based screening for HPV+OPSCC may be feasible years prior to diagnosis. METHODS: We developed an HPV whole genome sequencing assay, HPV-DeepSeek, with 99% sensitivity and specificity at clinical diagnosis...
February 2, 2024: medRxiv
https://read.qxmd.com/read/38053844/age-related-upregulation-of-perineuronal-nets-on-inferior-collicular-cells-that-project-to-the-cochlear-nucleus
#5
JOURNAL ARTICLE
Laila S Almassri, Andrew P Ohl, Milena C Iafrate, Aidan D Wade, Nick J Tokar, Amir M Mafi, Nichole L Beebe, Jesse W Young, Jeffrey G Mellott
INTRODUCTION: Disruptions to the balance of excitation and inhibition in the inferior colliculus (IC) occur during aging and underlie various aspects of hearing loss. Specifically, the age-related alteration to GABAergic neurotransmission in the IC likely contributes to the poorer temporal precision characteristic of presbycusis. Perineuronal nets (PNs), a specialized form of the extracellular matrix, maintain excitatory/inhibitory synaptic environments and reduce structural plasticity...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38019932/t-cell-responses-to-sars-cov-2-infection-and-vaccination-are-elevated-in-b-cell-deficiency-and-reduce-risk-of-severe-covid-19
#6
JOURNAL ARTICLE
Reza Zonozi, Lucy C Walters, Aaron Shulkin, Vivek Naranbhai, Pravarut Nithagon, Gabriel Sauvage, Clarety Kaeske, Katherine Cosgrove, Anusha Nathan, Rhoda Tano-Menka, Alton C Gayton, Matthew A Getz, Fernando Senjobe, Daniel Worrall, A John Iafrate, Caroline Fromson, Sydney B Montesi, Deepak A Rao, Jeffrey A Sparks, Zachary S Wallace, Jocelyn R Farmer, Bruce D Walker, Richelle C Charles, Karen Laliberte, John L Niles, Gaurav D Gaiha
Individuals with primary and pharmacologic B cell deficiencies have high rates of severe disease and mortality from coronavirus disease 2019 (COVID-19), but the immune responses and clinical outcomes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination have yet to be fully defined. Here, we evaluate the cellular immune responses after both SARS-CoV-2 infection and vaccination in patients receiving the anti-CD20 therapy rituximab (RTX) and those with low B cell counts due to common variable immune deficiency (CVID) disease...
November 29, 2023: Science Translational Medicine
https://read.qxmd.com/read/37938048/evidence-of-atlantic-midshipman-porichthys-plectrodon-vocalizations-from-an-unmanned-surface-vehicle-in-the-u-s-south-atlantica
#7
JOURNAL ARTICLE
Joseph Iafrate, Eric Reyier, Bonnie Ahr, Alexandra Carroll, Aaron N Rice, Georges Dossot, Stephanie L Watwood, Debra Murie
An unmanned surface vehicle (USV; Wave Glider) was deployed to study the coastal soundscape in shallow (less than 30 m) coastal waters off the coast of Cape Canaveral, FL, in July 2020 and January 2022. These surveys documented temporal and seasonal trends in biological sounds across a variety of habitats within an 812-km2 survey area, including sand shoals, sand-mud plains, and natural hardbottom. Among a broader diversity of identifiable and unidentifiable fish choruses recorded during the survey, a distinct and previously unidentified fish chorus was recorded; corroborating evidence suggests it and other sounds with similar spectral properties may be produced by Atlantic midshipman...
November 1, 2023: Journal of the Acoustical Society of America
https://read.qxmd.com/read/37922440/virtual-molecular-and-precision-medicine-clinic-to-improve-access-to-clinical-trials-for-patients-with-metastatic-breast-cancer-an-academic-community-collaboration
#8
JOURNAL ARTICLE
Laura M Spring, Lindsey Mortensen, Elizabeth Abraham, Jennifer Keenan, Arielle Medford, Annie Ma, Sarah Padden, Elyssa Denault, Lianne Ryan, A John Iafrate, Jochen Lennerz, Ephraim Hochberg, Seth A Wander, Beverly Moy, Steven J Isakoff, Dejan Juric, Kimberly A Brennan, Deborah E Smith, Barbara Civiello, Therese Mulvey, Amy Comander, Leif W Ellisen, Joel H Schwartz, Aditya Bardia
PURPOSE: There is a demand for improved care delivery surrounding genomic testing and clinical trial enrollment among patients with metastatic breast cancer (MBC). We sought to improve the current process via real-time informal consultation and prescreening assessment for patients with MBC treated by community and academic medical oncologists by implementing a virtual molecular and precision medicine (vMAP) clinic. METHODS: The vMAP program used a virtual referral system directed to a multidisciplinary team with precision medicine expertise...
January 2024: JCO oncology practice
https://read.qxmd.com/read/37868695/unveiling-the-gender-gap-exploring-gender-disparities-in-european-academic-landscape
#9
JOURNAL ARTICLE
Sara Farina, Raffaella Iafrate, Stefania Boccia
No abstract text is available yet for this article.
November 2023: The Lancet regional health. Europe
https://read.qxmd.com/read/37771083/atypical-cystic-hypersecretory-lesions-of-the-breast-commonly-harbour-tp53-alterations
#10
JOURNAL ARTICLE
Baris Boyraz, Dennis C Sgroi, A John Iafrate, Melinda F Lerwill
AIMS: Cystic hypersecretory lesions are rare and include atypical cystic hypersecretory hyperplasia (A-CHH) and cystic hypersecretory carcinoma in situ (CHC-IS). Despite detailed morphological descriptions, little is known about the genetic landscape of these lesions. METHODS AND RESULTS: We identified four A-CHH and three CHC-IS from 2010 to 2022. Patients ranged from 39 to 65 (median 49) years. All lesions showed characteristic cystically dilated ducts with colloid-like secretions lined by enlarged cells with hyperchromatic nuclei and at least moderate cytological atypia...
December 2023: Histopathology
https://read.qxmd.com/read/37719180/penile-calciphylaxis-infrequent-complication-with-bad-prognosis-a-case-report
#11
Tommaso Ceccato, Martina Bruniera, Massimo Iafrate, Fabrizio Dal Moro
68-years-old man with end-stage-renal-disease (ESRD) and obesity presented with painful penile lesion: necrotic glans, extended till the penile base with the exposition of corpora cavernosa. Laboratory testing were normal and was afebrile so subsequently discharged with antibiotic therapy and medications. Clinical evaluation was suggestive for penile calciphylaxis, confirmed by seeing arterial calcifications at CT. Patient died one month later. Penile calciphylaxis is a rare life-threatening condition characterized by vascular calcification and fibrosis of medium and small arteries which causes an obstructive vasculopathy and tissue necrosis...
September 2023: Urology Case Reports
https://read.qxmd.com/read/37630006/a-study-of-repair-mortars-for-restoration-of-wall-painted-plasters-in-a-hypogeum-rock-cut-church-of-matera-southern-italy
#12
JOURNAL ARTICLE
Manuel Giandomenico, Filippo Edoardo Capasso, Sokol Muca, Maria Carolina Gaetani, Giovanni Quarta, Sara Iafrate, Davide Melica, Angela Calia
Several lime mortars for the repair of painted plasters of the rock-cut church of Ss. Pietro and Paolo in Matera were studied. They were designed taking into account both aesthetic criteria that need to be fulfilled in the field of paintings restoration, and physical-mechanical compatibility with the original materials on site, i.e., the pre-existing plasters and the supporting rock. Mixes with calcareous and silica aggregates, based on different grain size proportions, were prepared to fill missing portions of the original painted plaster...
August 21, 2023: Materials
https://read.qxmd.com/read/37629557/chronic-prostatitis-chronic-pain-pelvic-syndrome-and-male-infertility
#13
REVIEW
Andrea Graziani, Giuseppe Grande, Michel Martin, Giordana Ferraioli, Elena Colonnello, Massimo Iafrate, Fabrizio Dal Moro, Alberto Ferlin
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is defined as urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months. The rate of symptoms related to prostatitis has a mean prevalence of 8-8.2%. CP/CPPS is most frequent in men younger than 50 years, among whom it is the most common urologic diagnosis. In the last decades, many studies have been published on CP/CPPS and its association with male infertility...
August 7, 2023: Life
https://read.qxmd.com/read/37561981/the-cholangiocarcinoma-in-the-young-city-study-tumor-biology-treatment-patterns-and-survival-outcomes-in-adolescent-young-adults-with-cholangiocarcinoma
#14
JOURNAL ARTICLE
Leontios Pappas, Islam Baiev, Stephanie Reyes, Andrea Grace Bocobo, Apurva Jain, Kristen Spencer, Tri Minh Le, Osama E Rahma, Jordan Maurer, Jen Stanton, Karen Zhang, Anaemy Danner De Armas, Thomas T Deleon, Marc Roth, Mary Linton B Peters, Andrew X Zhu, Kylie Boyhen, Christine VanCott, Tushar Patel, Lewis R Roberts, Stacie Lindsey, Nora Horick, Jochen K Lennerz, A John Iafrate, Laura Williams Goff, Kabir Mody, Mitesh J Borad, Rachna T Shroff, Milind M Javle, R Katie Kelley, Lipika Goyal
PURPOSE: Increased awareness of the distinct tumor biology for adolescents and young adults (AYAs) with cancer has led to improvement in outcomes for this population. However, in cholangiocarcinoma (CCA), a paucity of data exist on the AYA population. To our knowledge, we present the largest study to date on AYA disease biology, treatment patterns, and survival outcomes in CCA. METHODS: A multi-institutional cohort of patients with CCA diagnosed with intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma (ECC) was used for analysis...
August 2023: JCO Precision Oncology
https://read.qxmd.com/read/37552265/urology-a-trip-into-metaverse
#15
JOURNAL ARTICLE
Gianmarco Randazzo, Giuseppe Reitano, Filippo Carletti, Massimo Iafrate, Giovanni Betto, Giacomo Novara, Fabrizio Dal Moro, Fabio Zattoni
PURPOSE: Metaverse is becoming an alternative world in which technology and virtual experiences are mixed with real life, and it holds the promise of changing our way of living. Healthcare is already changing thanks to Metaverse and its numerous applications. In particular, Urology and urologic patients can benefit in many ways from Metaverse. METHODS: A non-systematic literature review identified recently published studies dealing with Metaverse. The database used for this review was PubMed, and the identified studies served as the base for a narrative analysis of the literature that explored the use of Metaverse in Urology...
August 8, 2023: World Journal of Urology
https://read.qxmd.com/read/37509076/tissue-inhibitor-of-matrix-metalloproteinases-1-timp-1-and-pulmonary-involvement-in-covid-19-pneumonia
#16
JOURNAL ARTICLE
Maria Antonella Zingaropoli, Tiziana Latronico, Patrizia Pasculli, Giorgio Maria Masci, Roberta Merz, Federica Ciccone, Federica Dominelli, Cosmo Del Borgo, Miriam Lichtner, Franco Iafrate, Gioacchino Galardo, Francesco Pugliese, Valeria Panebianco, Paolo Ricci, Carlo Catalano, Maria Rosa Ciardi, Grazia Maria Liuzzi, Claudio Maria Mastroianni
Background: The aim of the study was to longitudinally evaluate the association between MMP-2, MMP-9, TIMP-1 and chest radiological findings in COVID-19 patients. Methods: COVID-19 patients were evaluated based on their hospital admission (baseline) and three months after hospital discharge (T post) and were stratified into ARDS and non-ARDS groups. As a control group, healthy donors (HD) were enrolled. Results: At the baseline, compared to HD (n = 53), COVID-19 patients (n = 129) showed higher plasma levels of MMP-9 ( p < 0...
June 26, 2023: Biomolecules
https://read.qxmd.com/read/37483852/neutrophil-to-lymphocyte-ratio-as-a-prognostic-factor-for-patients-with-urothelial-carcinoma-of-the-bladder-following-radical-cystectomy
#17
JOURNAL ARTICLE
Fabio Zattoni, Giacomo Novara, Massimo Iafrate, Filippo Carletti, Giuseppe Reitano, Gianmarco Randazzo, Tommaso Ceccato, Giovanni Betto, Fabrizio Dal Moro
INTRODUCTION: The pre-treatment neutrophil-to-lymphocyte ratio (NLR) has been associated with adverse pathology or survival in a variety of malignancies, including urothelial carcinoma of the bladder (UCB) treated with radical cystectomy (RC). Whether the prognostic value of NLR is retained, or even increased, when measured postoperatively remains to be studied. In this study, we evaluated the association of preoperative and postoperative NLR with oncological outcomes following RC. MATERIAL AND METHODS: The NLR was recorded in 132 consecutive patients with UCB treated with open RC: before surgery (NLR1), postoperatively within 2 days (NRL2), between 7 and 15 days after RC before discharge (NLR3), and a few days before recurrence or last available follow-up (NLR4)...
2023: Central European Journal of Urology
https://read.qxmd.com/read/37437226/integrated-radiology-pathology-and-pharmacy-program-to-accelerate-access-to-osimertinib
#18
JOURNAL ARTICLE
Ibiayi Dagogo-Jack, Amanda Manoogian, Nicholas Jessop, N Zeke Georgantas, Florian J Fintelmann, Alexander Farahani, Subba R Digumarthy, Melissa C Price, Erik E Folch, Colleen M Keyes, Andrew Do, Jennifer L Peterson, Mari Mino-Kenudson, Martha Pitman, Miguel Rivera, Valentina Nardi, Dora Dias-Santagata, Long P Le, Anthony John Iafrate, Rebecca S Heist, Lauren R Ritterhouse, Jochen K Lennerz
A workflow involving radiology, pathology, pharmacy, and oncology reduced time between biopsy and osimertinib.
July 12, 2023: JCO oncology practice
https://read.qxmd.com/read/37437144/braf-mek-inhibition-in-newly-diagnosed-papillary-craniopharyngiomas
#19
JOURNAL ARTICLE
Priscilla K Brastianos, Erin Twohy, Susan Geyer, Elizabeth R Gerstner, Timothy J Kaufmann, Shervin Tabrizi, Brian Kabat, Julia Thierauf, Michael W Ruff, Daniela A Bota, David A Reardon, Adam L Cohen, Macarena I De La Fuente, Glenn J Lesser, Jian Campian, Pankaj K Agarwalla, Priya Kumthekar, Bhupinder Mann, Shivangi Vora, Michael Knopp, A John Iafrate, William T Curry, Daniel P Cahill, Helen A Shih, Paul D Brown, Sandro Santagata, Fred G Barker, Evanthia Galanis
BACKGROUND: Craniopharyngiomas, primary brain tumors of the pituitary-hypothalamic axis, can cause clinically significant sequelae. Treatment with the use of surgery, radiation, or both is often associated with substantial morbidity related to vision loss, neuroendocrine dysfunction, and memory loss. Genotyping has shown that more than 90% of papillary craniopharyngiomas carry BRAF V600E mutations, but data are lacking with regard to the safety and efficacy of BRAF-MEK inhibition in patients with papillary craniopharyngiomas who have not undergone previous radiation therapy...
July 13, 2023: New England Journal of Medicine
https://read.qxmd.com/read/37390098/prognostic-biomarkers-for-survival-in-mucosal-melanoma
#20
JOURNAL ARTICLE
Julia C Thierauf, Stefan T Kaluziak, Elizabeth Codd, Stacy N Dybel, Soma Jobbagy, Rashi Purohit, Alex A Farahani, Aikaterini Dedeilia, Vivek Naranbhai, Mai P Hoang, Adam S Fisch, Lauren Ritterhouse, Genevieve M Boland, Jochen K Lennerz, A John Iafrate
Mucosal melanoma (MM) is a rare subtype of melanoma with an aggressive clinical course. In cutaneous melanoma (CM), the absence of pigmentation and presence of NRAS/KRAS mutations are biomarkers indicating an aggressive clinical course with shorter overall survival. Similar data for MM are missing. We present the real-world outcome data in a cohort of genotyped MM patients and assessed the prognostic relevance of pigmentation- and NRAS/KRAS mutation status. We correlated pathological reports and clinical data with overall survival of patients with MM...
June 30, 2023: Pigment Cell & Melanoma Research
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