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https://www.readbyqxmd.com/read/28088512/ros1-fusions-rarely-overlap-with-other-oncogenic-drivers-in-non-small-cell-lung-cancer
#1
Jessica J Lin, Lauren L Ritterhouse, Siraj M Ali, Mark Bailey, Alexa B Schrock, Justin F Gainor, Lorin A Ferris, Mari Mino-Kenudson, Vincent A Miller, Anthony J Iafrate, Jochen K Lennerz, Alice T Shaw
INTRODUCTION: Chromosomal rearrangements involving the ROS proto-oncogene 1 receptor tyrosine kinase gene (ROS1) define a distinct molecular subset of non-small cell lung cancer (NSCLC) with sensitivity to ROS1 inhibitors. Recent reports have suggested a significant overlap between ROS1 fusions and other oncogenic driver alterations, including mutations in epidermal growth factor receptor (EGFR) and KRAS proto-oncogene (KRAS). METHODS: We identified patients at our institution with ROS1-rearranged NSCLC who had undergone testing for genetic alterations in additional oncogenes, including EGFR, KRAS, and anaplastic lymphoma kinase (ALK)...
January 11, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28059100/a-tailored-approach-to-braf-and-mlh1-methylation-testing-in-a-universal-screening-program-for-lynch-syndrome
#2
Tomer Adar, Linda H Rodgers, Kristen M Shannon, Makoto Yoshida, Tianle Ma, Anthony Mattia, Gregory Y Lauwers, Anthony J Iafrate, Daniel C Chung
To determine the correlation between BRAF genotype and MLH1 promoter methylation in a screening program for Lynch syndrome (LS), a universal screening program for LS was established in two medical centers. Tumors with abnormal MLH1 staining were evaluated for both BRAF V600E genotype and MLH1 promoter methylation. Tumors positive for both were considered sporadic, and genetic testing was recommended for all others. A total 1011 colorectal cancer cases were screened for Lynch syndrome, and 148 (14.6%) exhibited absent MLH1 immunostaining...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28034880/polyclonal-secondary-fgfr2-mutations-drive-acquired-resistance-to-fgfr-inhibition-in-patients-with-fgfr2-fusion-positive-cholangiocarcinoma
#3
Lipika Goyal, Supriya K Saha, Leah Y Liu, Giulia Siravegna, Ignaty Leshchiner, Leanne G Ahronian, Jochen K Lennerz, Phuong Vu, Vikram Deshpande, Avinash Kambadakone, Benedetta Mussolin, Stephanie Reyes, Laura Henderson, Jiaoyuan Elisabeth Sun, Emily E Van Seventer, Joseph M Gurski, Sabrina Baltschukat, Barbara Schacher-Engstler, Louise Barys, Christelle Stamm, Pascal Furet, David P Ryan, James R Stone, A John Iafrate, Gad Getz, Diana Graus Porta, Ralph Tiedt, Alberto Bardelli, Dejan Juric, Ryan B Corcoran, Nabeel Bardeesy, Andrew X Zhu
Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in many cancers, including intrahepatic cholangiocarcinoma (ICC). The FGFR inhibitor BGJ398 displayed encouraging efficacy in patients with FGFR2 fusion-positive ICC in a phase II trial, but the durability of response was limited in some patients. Here, we report the molecular basis for acquired resistance to BGJ398 in three patients via integrative genomic characterization of cell-free circulating tumor DNA (cfDNA), primary tumors, and metastases...
December 29, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/28032319/religiosity-marital-quality-and-couple-generativity-in-italian-couples-belonging-to-a-catholic-spiritual-association-a-quali-quantitative-study
#4
Miriam Parise, Fabiana Gatti, Raffaella Iafrate
The current studies aimed, firstly, at exploring the relationship between the level of religiosity and marital outcomes, in terms of relationship quality and couple generativity; secondly, at gaining insight into which strategies the couples use to ensure their marital quality/couple generativity, and understanding if religious practices have a positive influence on the development of such strategies. The studies focused on a specific aspect of religiosity, that is the active involvement in a Catholic association, and compared couples with a high level of religious involvement (HRI) belonging to a Catholic international association (New Families) and couples with a low level of religious involvement (LRI)...
December 28, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27984905/outstanding-performance-of-configuration-interaction-singles-and-doubles-using-exact-exchange-kohn-sham-orbitals-in-real-space-numerical-grid-method
#5
Jaechang Lim, Sunghwan Choi, Jaewook Kim, Woo Youn Kim
To assess the performance of multi-configuration methods using exact exchange Kohn-Sham (KS) orbitals, we implemented configuration interaction singles and doubles (CISD) in a real-space numerical grid code. We obtained KS orbitals with the exchange-only optimized effective potential under the Krieger-Li-Iafrate (KLI) approximation. Thanks to the distinctive features of KLI orbitals against Hartree-Fock (HF), such as bound virtual orbitals with compact shapes and orbital energy gaps similar to excitation energies; KLI-CISD for small molecules shows much faster convergence as a function of simulation box size and active space (i...
December 14, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27913435/idh2-mutations-define-a-unique-subtype-of-breast-cancer-with-altered-nuclear-polarity
#6
Sarah Chiang, Britta Weigelt, Huei-Chi Wen, Fresia Pareja, Ashwini Raghavendra, Luciano G Martelotto, Kathleen A Burke, Thais Basili, Anqi Li, Felipe C Geyer, Salvatore Piscuoglio, Charlotte K Y Ng, Achim A Jungbluth, Jörg Balss, Stefan Pusch, Gabrielle M Baker, Kimberly S Cole, Andreas von Deimling, Julie M Batten, Jonathan D Marotti, Hwei-Choo Soh, Benjamin L McCalip, Jonathan Serrano, Raymond S Lim, Kalliopi P Siziopikou, Song Lu, Xiaolong Liu, Tarek Hammour, Edi Brogi, Matija Snuderl, A John Iafrate, Jorge S Reis-Filho, Stuart J Schnitt
Solid papillary carcinoma with reverse polarity (SPCRP) is a rare breast cancer subtype with an obscure etiology. In this study, we sought to describe its unique histopathologic features and to identify the genetic alterations that underpin SPCRP using massively parallel whole-exome and targeted sequencing. The morphologic and immunohistochemical features of SPCRP support the invasive nature of this subtype. Ten of 13 (77%) SPCRPs harbored hotspot mutations at R172 of the isocitrate dehydrogenase IDH2, of which 8 of 10 displayed concurrent pathogenic mutations affecting PIK3CA or PIK3R1 One of the IDH2 wild-type SPCRPs harbored a TET2 Q548* truncating mutation coupled with a PIK3CA H1047R hotspot mutation...
December 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27880786/effects-of-pile-driving-on-the-residency-and-movement-of-tagged-reef-fish
#7
Joseph D Iafrate, Stephanie L Watwood, Eric A Reyier, Douglas M Scheidt, Georges A Dossot, Steven E Crocker
The potential effects of pile driving on fish populations and commercial fisheries have received significant attention given the prevalence of pile driving occurring in coastal habitats throughout the world. Behavioral impacts of sound generated from these activities on fish typically have a greater area of influence than physical injury, and may therefore adversely affect a greater portion of the local population. This study used acoustic telemetry to assess the movement, residency, and survival of 15 sheepshead (Archosargus probatocephalus) and 10 grey snapper (Lutjanus griseus) in Port Canaveral, Florida, USA, in response to 35 days of pile driving at a wharf complex...
2016: PloS One
https://www.readbyqxmd.com/read/27806376/single-cell-rna-seq-supports-a-developmental-hierarchy-in-human-oligodendroglioma
#8
Itay Tirosh, Andrew S Venteicher, Christine Hebert, Leah E Escalante, Anoop P Patel, Keren Yizhak, Jonathan M Fisher, Christopher Rodman, Christopher Mount, Mariella G Filbin, Cyril Neftel, Niyati Desai, Jackson Nyman, Benjamin Izar, Christina C Luo, Joshua M Francis, Aanand A Patel, Maristela L Onozato, Nicolo Riggi, Kenneth J Livak, Dave Gennert, Rahul Satija, Brian V Nahed, William T Curry, Robert L Martuza, Ravindra Mylvaganam, A John Iafrate, Matthew P Frosch, Todd R Golub, Miguel N Rivera, Gad Getz, Orit Rozenblatt-Rosen, Daniel P Cahill, Michelle Monje, Bradley E Bernstein, David N Louis, Aviv Regev, Mario L Suvà
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and epigenetic programs in which cancer stem cells (CSCs) can drive tumour growth and give rise to differentiated progeny. Yet, unbiased evidence for CSCs in solid human malignancies remains elusive. Here we profile 4,347 single cells from six IDH1 or IDH2 mutant human oligodendrogliomas by RNA sequencing (RNA-seq) and reconstruct their developmental programs from genome-wide expression signatures...
November 10, 2016: Nature
https://www.readbyqxmd.com/read/27698648/corrigendum-the-associations-of-dyadic-coping-and-relationship-satisfaction-vary-between-and-within-nations-a-35-nation-study
#9
Peter Hilpert, Ashley K Randall, Piotr Sorokowski, David C Atkins, Agnieszka Sorokowska, Khodabakhsh Ahmadi, Ahmad M Alghraibeh, Richmond Aryeetey, Anna Bertoni, Karim Bettache, Marta Błażejewska, Guy Bodenmann, Jessica Borders, Tiago S Bortolini, Marina Butovskaya, Felipe N Castro, Hakan Cetinkaya, Diana Cunha, Oana A David, Anita DeLongis, Fahd A Dileym, Alejandra D C Domínguez Espinosa, Silvia Donato, Daria Dronova, Seda Dural, Maryanne Fisher, Tomasz Frackowiak, Evrim Gulbetekin, Aslıhan Hamamcıoğlu Akkaya, Karolina Hansen, Wallisen T Hattori, Ivana Hromatko, Raffaella Iafrate, Bawo O James, Feng Jiang, Charles O Kimamo, David B King, Fırat Koç, Amos Laar, Fívia De Araújo Lopes, Rocio Martinez, Norbert Mesko, Natalya Molodovskaya, Khadijeh Moradi, Zahrasadat Motahari, Jean C Natividade, Joseph Ntayi, Oluyinka Ojedokun, Mohd S B Omar-Fauzee, Ike E Onyishi, Barış Özener, Anna Paluszak, Alda Portugal, Ana P Relvas, Muhammad Rizwan, Svjetlana Salkičević, Ivan Sarmány-Schuller, Eftychia Stamkou, Stanislava Stoyanova, Denisa Šukolová, Nina Sutresna, Meri Tadinac, Andero Teras, Edna L Tinoco Ponciano, Ritu Tripathi, Nachiketa Tripathi, Mamta Tripathi, Noa Vilchinsky, Feng Xu, Maria E Yamamoto, Gyesook Yoo
[This corrects the article on p. 1106 in vol. 7, PMID: 27551269.].
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27647802/next-generation-sequencing-adds-value-to-the-preoperative-diagnosis-of-pancreatic-cysts
#10
Matthew W Rosenbaum, Martin Jones, Jonathan C Dudley, Long P Le, A John Iafrate, Martha B Pitman
BACKGROUND: The diagnosis of a pancreatic cyst as mucinous or high-risk dictates the need for follow-up or surgery. Molecular analysis of aspirated pancreatic cyst fluid (PCF) can provide valuable information not obtained by carcinoembryonic antigen (CEA) analysis or cytology. METHODS: All patients who underwent molecular analysis of PCF between March 2013 and June 2015 were reviewed, including pathology, imaging, and follow-up. Molecular testing was performed using a patented, anchored multiplex polymerase chain reaction next-generation sequencing (NGS) platform, which sequenced numerous hotspots in 39 genes linked with malignancy...
September 20, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27556950/her2-expression-identifies-dynamic-functional-states-within-circulating-breast-cancer-cells
#11
Nicole Vincent Jordan, Aditya Bardia, Ben S Wittner, Cyril Benes, Matteo Ligorio, Yu Zheng, Min Yu, Tilak K Sundaresan, Joseph A Licausi, Rushil Desai, Ryan M O'Keefe, Richard Y Ebright, Myriam Boukhali, Srinjoy Sil, Maristela L Onozato, Anthony J Iafrate, Ravi Kapur, Dennis Sgroi, David T Ting, Mehmet Toner, Sridhar Ramaswamy, Wilhelm Haas, Shyamala Maheswaran, Daniel A Haber
Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targeted therapy, the clinical significance of acquired HER2 heterogeneity during the evolution of metastatic breast cancer is unknown. Here we analyse circulating tumour cells from 19 women with ER(+)/HER2(-) primary tumours, 84% of whom had acquired circulating tumour cells expressing HER2...
September 1, 2016: Nature
https://www.readbyqxmd.com/read/27551269/the-associations-of-dyadic-coping-and-relationship-satisfaction-vary-between-and-within-nations-a-35-nation-study
#12
Peter Hilpert, Ashley K Randall, Piotr Sorokowski, David C Atkins, Agnieszka Sorokowska, Khodabakhsh Ahmadi, Ahmad M Aghraibeh, Richmond Aryeetey, Anna Bertoni, Karim Bettache, Marta Błażejewska, Guy Bodenmann, Jessica Borders, Tiago S Bortolini, Marina Butovskaya, Felipe N Castro, Hakan Cetinkaya, Diana Cunha, Oana A David, Anita DeLongis, Fahd A Dileym, Alejandra D C Domínguez Espinosa, Silvia Donato, Daria Dronova, Seda Dural, Maryanne Fisher, Tomasz Frackowiak, Evrim Gulbetekin, Aslıhan Hamamcıoğlu Akkaya, Karolina Hansen, Wallisen T Hattori, Ivana Hromatko, Raffaella Iafrate, Bawo O James, Feng Jiang, Charles O Kimamo, David B King, Fırat Koç, Amos Laar, Fívia De Araújo Lopes, Rocio Martinez, Norbert Mesko, Natalya Molodovskaya, Khadijeh Moradi, Zahrasadat Motahari, Jean C Natividade, Joseph Ntayi, Oluyinka Ojedokun, Mohd S B Omar-Fauzee, Ike E Onyishi, Barış Özener, Anna Paluszak, Alda Portugal, Ana P Relvas, Muhammad Rizwan, Svjetlana Salkičević, Ivan Sarmány-Schuller, Eftychia Stamkou, Stanislava Stoyanova, Denisa Šukolová, Nina Sutresna, Meri Tadinac, Andero Teras, Edna L Tinoco Ponciano, Ritu Tripathi, Nachiketa Tripathi, Mamta Tripathi, Noa Vilchinsky, Feng Xu, Maria E Yamamoto, Gyesook Yoo
OBJECTIVE: Theories about how couples help each other to cope with stress, such as the systemic transactional model of dyadic coping, suggest that the cultural context in which couples live influences how their coping behavior affects their relationship satisfaction. In contrast to the theoretical assumptions, a recent meta-analysis provides evidence that neither culture, nor gender, influences the association between dyadic coping and relationship satisfaction, at least based on their samples of couples living in North America and West Europe...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27551012/metastatic-breast-cancer-with-esr1-mutation-clinical-management-considerations-from-the-molecular-and-precision-medicine-map-tumor-board-at-massachusetts-general-hospital
#13
Aditya Bardia, John A Iafrate, Tilak Sundaresan, Jerry Younger, Valentina Nardi
UNLABELLED: : The last decade in oncology has witnessed impressive response rates with targeted therapies, largely because of collaborative efforts at understanding tumor biology and careful patient selection based on molecular fingerprinting of the tumor. Consequently, there has been a push toward routine molecular genotyping of tumors, and large precision medicine-based clinical trials have been launched to match therapy to the molecular alteration seen in a tumor. However, selecting the "right drug" for an individual patient in clinic is a complex decision-making process, including analytical interpretation of the report, consideration of the importance of the molecular alteration in driving growth of the tumor, tumor heterogeneity, the availability of a matched targeted therapy, efficacy and toxicity considerations of the targeted therapy (compared with standard therapy), and reimbursement issues...
September 2016: Oncologist
https://www.readbyqxmd.com/read/27547025/transanal-minimally-invasive-surgery-for-rectal-lesions
#14
Silvia Quaresima, Andrea Balla, Luana Franceschilli, Marco La Torre, Corrado Iafrate, Mostafa Shalaby, Nicola Di Lorenzo, Pierpaolo Sileri
BACKGROUND AND OBJECTIVES: Transanal minimally invasive surgery (TAMIS) has emerged as an alternative to transanal endoscopic microsurgery (TEM). The authors report their experience with TAMIS for the treatment of mid and high rectal tumors. METHODS: From November 2011 through May 2016, 31 patients (21 females, 68%), with a median age of 65 years who underwent single-port TAMIS were prospectively enrolled. Mean distance from the anal verge of the rectal tumors was 9...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27471182/health-care-infrastructure-for-financially-sustainable-clinical-genomics
#15
Jochen K Lennerz, Heather M McLaughlin, Jason M Baron, David Rasmussen, Meini Sumbada Shin, Nancy Berners-Lee, Julie Miller Batten, Kathryn J Swoboda, Manish K Gala, Harland S Winter, Jeremy D Schmahmann, David A Sweetser, Marianne Boswell, Maciej Pacula, Albrecht Stenzinger, Long P Le, William Hynes, Heidi L Rehm, Anne Klibanski, Stephen W Black-Schaffer, Jeffrey A Golden, David N Louis, Scott T Weiss, A John Iafrate
Next-generation sequencing has evolved technically and economically into the method of choice for interrogating the genome in cancer and inherited disorders. The introduction of procedural code sets for whole-exome and genome sequencing is a milestone toward financially sustainable clinical implementation; however, achieving reimbursement is currently a major challenge. As part of a prospective quality-improvement initiative to implement the new code sets, we adopted Agile, a development methodology originally devised in software development...
September 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27432227/molecular-mechanisms-of-resistance-to-first-and-second-generation-alk-inhibitors-in-alk-rearranged-lung-cancer
#16
Justin F Gainor, Leila Dardaei, Satoshi Yoda, Luc Friboulet, Ignaty Leshchiner, Ryohei Katayama, Ibiayi Dagogo-Jack, Shirish Gadgeel, Katherine Schultz, Manrose Singh, Emily Chin, Melissa Parks, Dana Lee, Richard H DiCecca, Elizabeth Lockerman, Tiffany Huynh, Jennifer Logan, Lauren L Ritterhouse, Long P Le, Ashok Muniappan, Subba Digumarthy, Colleen Channick, Colleen Keyes, Gad Getz, Dora Dias-Santagata, Rebecca S Heist, Jochen Lennerz, Lecia V Sequist, Cyril H Benes, A John Iafrate, Mari Mino-Kenudson, Jeffrey A Engelman, Alice T Shaw
: Advanced, anaplastic lymphoma kinase (ALK)-positive lung cancer is currently treated with the first-generation ALK inhibitor crizotinib followed by more potent, second-generation ALK inhibitors (e.g., ceritinib and alectinib) upon progression. Second-generation inhibitors are generally effective even in the absence of crizotinib-resistant ALK mutations, likely reflecting incomplete inhibition of ALK by crizotinib in many cases. Herein, we analyzed 103 repeat biopsies from ALK-positive patients progressing on various ALK inhibitors...
October 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27360673/back-pain-in-a-junior-olympian-running-1848-june-2-2-20-pm-2-40-pm
#17
Julia L Iafrate, Karen L Newcomer
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27343442/acquired-resistance-to-crizotinib-in-nsclc-with-met%C3%A2-exon-14-skipping
#18
Rebecca S Heist, Lecia V Sequist, Darrell Borger, Justin F Gainor, Ronald S Arellano, Long P Le, Dora Dias-Santagata, Jeffrey W Clark, Jeffrey A Engelman, Alice T Shaw, A John Iafrate
INTRODUCTION: MET proto-oncogene, receptor tyrosine kinase gene (MET) exon 14 skipping is a targetable alteration in lung cancer. Treatment with MET proto-oncogene, receptor tyrosine kinase inhibitor can cause dramatic responses in patients whose cancers have MET exon 14 skipping. Little is known, however, about acquired resistance in patients with MET exon 14 skipping. METHODS: Biopsy specimens obtained at baseline and at the time of progression for a patient being treated with crizotinib were compared using targeted next-generation sequencing to assess for mechanisms of resistance...
August 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27228285/a-circulating-mirna-assay-as-a-first-line-test-for-prostate-cancer-screening
#19
Evgeniya Sharova, Angela Grassi, Anna Marcer, Katia Ruggero, Francesco Pinto, Pierfrancesco Bassi, Paola Zanovello, Filiberto Zattoni, Donna M D'Agostino, Massimo Iafrate, Vincenzo Ciminale
BACKGROUND: Prostate cancer (PCa) screening currently relies on prostate-specific antigen (PSA) testing and digital rectal examination. However, recent large-scale studies have questioned the long-term efficacy of these tests, and biomarkers that accurately identify PCa are needed. METHODS: We analysed the levels of circulating microRNAs (miRNAs) in patients with elevated PSA who were diagnosed with either localised PCa (n=36) or benign prostatic hyperplasia (BPH, n=31) upon biopsy...
June 14, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27127954/resolving-the-extragalactic-%C3%AE-ray-background-above-50%C3%A2-gev-with-the-fermi-large-area-telescope
#20
M Ackermann, M Ajello, A Albert, W B Atwood, L Baldini, J Ballet, G Barbiellini, D Bastieri, K Bechtol, R Bellazzini, E Bissaldi, R D Blandford, E D Bloom, R Bonino, J Bregeon, R J Britto, P Bruel, R Buehler, G A Caliandro, R A Cameron, M Caragiulo, P A Caraveo, E Cavazzuti, C Cecchi, E Charles, A Chekhtman, J Chiang, G Chiaro, S Ciprini, J Cohen-Tanugi, L R Cominsky, F Costanza, S Cutini, F D'Ammando, A de Angelis, F de Palma, R Desiante, S W Digel, M Di Mauro, L Di Venere, A Domínguez, P S Drell, C Favuzzi, S J Fegan, E C Ferrara, A Franckowiak, Y Fukazawa, S Funk, P Fusco, F Gargano, D Gasparrini, N Giglietto, P Giommi, F Giordano, M Giroletti, G Godfrey, D Green, I A Grenier, S Guiriec, E Hays, D Horan, G Iafrate, T Jogler, G Jóhannesson, M Kuss, G La Mura, S Larsson, L Latronico, J Li, L Li, F Longo, F Loparco, B Lott, M N Lovellette, P Lubrano, G M Madejski, J Magill, S Maldera, A Manfreda, M Mayer, M N Mazziotta, P F Michelson, W Mitthumsiri, T Mizuno, A A Moiseev, M E Monzani, A Morselli, I V Moskalenko, S Murgia, M Negro, E Nuss, T Ohsugi, C Okada, N Omodei, E Orlando, J F Ormes, D Paneque, J S Perkins, M Pesce-Rollins, V Petrosian, F Piron, G Pivato, T A Porter, S Rainò, R Rando, M Razzano, S Razzaque, A Reimer, O Reimer, T Reposeur, R W Romani, M Sánchez-Conde, J Schmid, A Schulz, C Sgrò, D Simone, E J Siskind, F Spada, G Spandre, P Spinelli, D J Suson, H Takahashi, J B Thayer, L Tibaldo, D F Torres, E Troja, G Vianello, M Yassine, S Zimmer
The Fermi Large Area Telescope (LAT) Collaboration has recently released a catalog of 360 sources detected above 50 GeV (2FHL). This catalog was obtained using 80 months of data re-processed with Pass 8, the newest event-level analysis, which significantly improves the acceptance and angular resolution of the instrument. Most of the 2FHL sources at high Galactic latitude are blazars. Using detailed Monte Carlo simulations, we measure, for the first time, the source count distribution, dN/dS, of extragalactic γ-ray sources at E>50  GeV and find that it is compatible with a Euclidean distribution down to the lowest measured source flux in the 2FHL (∼8×10^{-12}  ph cm^{-2} s^{-1})...
April 15, 2016: Physical Review Letters
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