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https://www.readbyqxmd.com/read/27880786/effects-of-pile-driving-on-the-residency-and-movement-of-tagged-reef-fish
#1
Joseph D Iafrate, Stephanie L Watwood, Eric A Reyier, Douglas M Scheidt, Georges A Dossot, Steven E Crocker
The potential effects of pile driving on fish populations and commercial fisheries have received significant attention given the prevalence of pile driving occurring in coastal habitats throughout the world. Behavioral impacts of sound generated from these activities on fish typically have a greater area of influence than physical injury, and may therefore adversely affect a greater portion of the local population. This study used acoustic telemetry to assess the movement, residency, and survival of 15 sheepshead (Archosargus probatocephalus) and 10 grey snapper (Lutjanus griseus) in Port Canaveral, Florida, USA, in response to 35 days of pile driving at a wharf complex...
2016: PloS One
https://www.readbyqxmd.com/read/27806376/single-cell-rna-seq-supports-a-developmental-hierarchy-in-human-oligodendroglioma
#2
Itay Tirosh, Andrew S Venteicher, Christine Hebert, Leah E Escalante, Anoop P Patel, Keren Yizhak, Jonathan M Fisher, Christopher Rodman, Christopher Mount, Mariella G Filbin, Cyril Neftel, Niyati Desai, Jackson Nyman, Benjamin Izar, Christina C Luo, Joshua M Francis, Aanand A Patel, Maristela L Onozato, Nicolo Riggi, Kenneth J Livak, Dave Gennert, Rahul Satija, Brian V Nahed, William T Curry, Robert L Martuza, Ravindra Mylvaganam, A John Iafrate, Matthew P Frosch, Todd R Golub, Miguel N Rivera, Gad Getz, Orit Rozenblatt-Rosen, Daniel P Cahill, Michelle Monje, Bradley E Bernstein, David N Louis, Aviv Regev, Mario L Suvà
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and epigenetic programs in which cancer stem cells (CSCs) can drive tumour growth and give rise to differentiated progeny. Yet, unbiased evidence for CSCs in solid human malignancies remains elusive. Here we profile 4,347 single cells from six IDH1 or IDH2 mutant human oligodendrogliomas by RNA sequencing (RNA-seq) and reconstruct their developmental programs from genome-wide expression signatures...
November 2, 2016: Nature
https://www.readbyqxmd.com/read/27698648/corrigendum-the-associations-of-dyadic-coping-and-relationship-satisfaction-vary-between-and-within-nations-a-35-nation-study
#3
Peter Hilpert, Ashley K Randall, Piotr Sorokowski, David C Atkins, Agnieszka Sorokowska, Khodabakhsh Ahmadi, Ahmad M Alghraibeh, Richmond Aryeetey, Anna Bertoni, Karim Bettache, Marta Błażejewska, Guy Bodenmann, Jessica Borders, Tiago S Bortolini, Marina Butovskaya, Felipe N Castro, Hakan Cetinkaya, Diana Cunha, Oana A David, Anita DeLongis, Fahd A Dileym, Alejandra D C Domínguez Espinosa, Silvia Donato, Daria Dronova, Seda Dural, Maryanne Fisher, Tomasz Frackowiak, Evrim Gulbetekin, Aslıhan Hamamcıoğlu Akkaya, Karolina Hansen, Wallisen T Hattori, Ivana Hromatko, Raffaella Iafrate, Bawo O James, Feng Jiang, Charles O Kimamo, David B King, Fırat Koç, Amos Laar, Fívia De Araújo Lopes, Rocio Martinez, Norbert Mesko, Natalya Molodovskaya, Khadijeh Moradi, Zahrasadat Motahari, Jean C Natividade, Joseph Ntayi, Oluyinka Ojedokun, Mohd S B Omar-Fauzee, Ike E Onyishi, Barış Özener, Anna Paluszak, Alda Portugal, Ana P Relvas, Muhammad Rizwan, Svjetlana Salkičević, Ivan Sarmány-Schuller, Eftychia Stamkou, Stanislava Stoyanova, Denisa Šukolová, Nina Sutresna, Meri Tadinac, Andero Teras, Edna L Tinoco Ponciano, Ritu Tripathi, Nachiketa Tripathi, Mamta Tripathi, Noa Vilchinsky, Feng Xu, Maria E Yamamoto, Gyesook Yoo
[This corrects the article on p. 1106 in vol. 7, PMID: 27551269.].
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27647802/next-generation-sequencing-adds-value-to-the-preoperative-diagnosis-of-pancreatic-cysts
#4
Matthew W Rosenbaum, Martin Jones, Jonathan C Dudley, Long P Le, A John Iafrate, Martha B Pitman
BACKGROUND: The diagnosis of a pancreatic cyst as mucinous or high-risk dictates the need for follow-up or surgery. Molecular analysis of aspirated pancreatic cyst fluid (PCF) can provide valuable information not obtained by carcinoembryonic antigen (CEA) analysis or cytology. METHODS: All patients who underwent molecular analysis of PCF between March 2013 and June 2015 were reviewed, including pathology, imaging, and follow-up. Molecular testing was performed using a patented, anchored multiplex polymerase chain reaction next-generation sequencing (NGS) platform, which sequenced numerous hotspots in 39 genes linked with malignancy...
September 20, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27556950/her2-expression-identifies-dynamic-functional-states-within-circulating-breast-cancer-cells
#5
Nicole Vincent Jordan, Aditya Bardia, Ben S Wittner, Cyril Benes, Matteo Ligorio, Yu Zheng, Min Yu, Tilak K Sundaresan, Joseph A Licausi, Rushil Desai, Ryan M O'Keefe, Richard Y Ebright, Myriam Boukhali, Srinjoy Sil, Maristela L Onozato, Anthony J Iafrate, Ravi Kapur, Dennis Sgroi, David T Ting, Mehmet Toner, Sridhar Ramaswamy, Wilhelm Haas, Shyamala Maheswaran, Daniel A Haber
Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targeted therapy, the clinical significance of acquired HER2 heterogeneity during the evolution of metastatic breast cancer is unknown. Here we analyse circulating tumour cells from 19 women with ER(+)/HER2(-) primary tumours, 84% of whom had acquired circulating tumour cells expressing HER2...
August 24, 2016: Nature
https://www.readbyqxmd.com/read/27551269/the-associations-of-dyadic-coping-and-relationship-satisfaction-vary-between-and-within-nations-a-35-nation-study
#6
Peter Hilpert, Ashley K Randall, Piotr Sorokowski, David C Atkins, Agnieszka Sorokowska, Khodabakhsh Ahmadi, Ahmad M Aghraibeh, Richmond Aryeetey, Anna Bertoni, Karim Bettache, Marta Błażejewska, Guy Bodenmann, Jessica Borders, Tiago S Bortolini, Marina Butovskaya, Felipe N Castro, Hakan Cetinkaya, Diana Cunha, Oana A David, Anita DeLongis, Fahd A Dileym, Alejandra D C Domínguez Espinosa, Silvia Donato, Daria Dronova, Seda Dural, Maryanne Fisher, Tomasz Frackowiak, Evrim Gulbetekin, Aslıhan Hamamcıoğlu Akkaya, Karolina Hansen, Wallisen T Hattori, Ivana Hromatko, Raffaella Iafrate, Bawo O James, Feng Jiang, Charles O Kimamo, David B King, Fırat Koç, Amos Laar, Fívia De Araújo Lopes, Rocio Martinez, Norbert Mesko, Natalya Molodovskaya, Khadijeh Moradi, Zahrasadat Motahari, Jean C Natividade, Joseph Ntayi, Oluyinka Ojedokun, Mohd S B Omar-Fauzee, Ike E Onyishi, Barış Özener, Anna Paluszak, Alda Portugal, Ana P Relvas, Muhammad Rizwan, Svjetlana Salkičević, Ivan Sarmány-Schuller, Eftychia Stamkou, Stanislava Stoyanova, Denisa Šukolová, Nina Sutresna, Meri Tadinac, Andero Teras, Edna L Tinoco Ponciano, Ritu Tripathi, Nachiketa Tripathi, Mamta Tripathi, Noa Vilchinsky, Feng Xu, Maria E Yamamoto, Gyesook Yoo
OBJECTIVE: Theories about how couples help each other to cope with stress, such as the systemic transactional model of dyadic coping, suggest that the cultural context in which couples live influences how their coping behavior affects their relationship satisfaction. In contrast to the theoretical assumptions, a recent meta-analysis provides evidence that neither culture, nor gender, influences the association between dyadic coping and relationship satisfaction, at least based on their samples of couples living in North America and West Europe...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27551012/metastatic-breast-cancer-with-esr1-mutation-clinical-management-considerations-from-the-molecular-and-precision-medicine-map-tumor-board-at-massachusetts-general-hospital
#7
Aditya Bardia, John A Iafrate, Tilak Sundaresan, Jerry Younger, Valentina Nardi
UNLABELLED: : The last decade in oncology has witnessed impressive response rates with targeted therapies, largely because of collaborative efforts at understanding tumor biology and careful patient selection based on molecular fingerprinting of the tumor. Consequently, there has been a push toward routine molecular genotyping of tumors, and large precision medicine-based clinical trials have been launched to match therapy to the molecular alteration seen in a tumor. However, selecting the "right drug" for an individual patient in clinic is a complex decision-making process, including analytical interpretation of the report, consideration of the importance of the molecular alteration in driving growth of the tumor, tumor heterogeneity, the availability of a matched targeted therapy, efficacy and toxicity considerations of the targeted therapy (compared with standard therapy), and reimbursement issues...
September 2016: Oncologist
https://www.readbyqxmd.com/read/27547025/transanal-minimally-invasive-surgery-for-rectal-lesions
#8
Silvia Quaresima, Andrea Balla, Luana Franceschilli, Marco La Torre, Corrado Iafrate, Mostafa Shalaby, Nicola Di Lorenzo, Pierpaolo Sileri
BACKGROUND AND OBJECTIVES: Transanal minimally invasive surgery (TAMIS) has emerged as an alternative to transanal endoscopic microsurgery (TEM). The authors report their experience with TAMIS for the treatment of mid and high rectal tumors. METHODS: From November 2011 through May 2016, 31 patients (21 females, 68%), with a median age of 65 years who underwent single-port TAMIS were prospectively enrolled. Mean distance from the anal verge of the rectal tumors was 9...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27471182/health-care-infrastructure-for-financially-sustainable-clinical-genomics
#9
Jochen K Lennerz, Heather M McLaughlin, Jason M Baron, David Rasmussen, Meini Sumbada Shin, Nancy Berners-Lee, Julie Miller Batten, Kathryn J Swoboda, Manish K Gala, Harland S Winter, Jeremy D Schmahmann, David A Sweetser, Marianne Boswell, Maciej Pacula, Albrecht Stenzinger, Long P Le, William Hynes, Heidi L Rehm, Anne Klibanski, Stephen W Black-Schaffer, Jeffrey A Golden, David N Louis, Scott T Weiss, A John Iafrate
Next-generation sequencing has evolved technically and economically into the method of choice for interrogating the genome in cancer and inherited disorders. The introduction of procedural code sets for whole-exome and genome sequencing is a milestone toward financially sustainable clinical implementation; however, achieving reimbursement is currently a major challenge. As part of a prospective quality-improvement initiative to implement the new code sets, we adopted Agile, a development methodology originally devised in software development...
September 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27432227/molecular-mechanisms-of-resistance-to-first-and-second-generation-alk-inhibitors-in-alk-rearranged-lung-cancer
#10
Justin F Gainor, Leila Dardaei, Satoshi Yoda, Luc Friboulet, Ignaty Leshchiner, Ryohei Katayama, Ibiayi Dagogo-Jack, Shirish Gadgeel, Katherine Schultz, Manrose Singh, Emily Chin, Melissa Parks, Dana Lee, Richard H DiCecca, Elizabeth Lockerman, Tiffany Huynh, Jennifer Logan, Lauren L Ritterhouse, Long P Le, Ashok Muniappan, Subba Digumarthy, Colleen Channick, Colleen Keyes, Gad Getz, Dora Dias-Santagata, Rebecca S Heist, Jochen Lennerz, Lecia V Sequist, Cyril H Benes, A John Iafrate, Mari Mino-Kenudson, Jeffrey A Engelman, Alice T Shaw
: Advanced, anaplastic lymphoma kinase (ALK)-positive lung cancer is currently treated with the first-generation ALK inhibitor crizotinib followed by more potent, second-generation ALK inhibitors (e.g., ceritinib and alectinib) upon progression. Second-generation inhibitors are generally effective even in the absence of crizotinib-resistant ALK mutations, likely reflecting incomplete inhibition of ALK by crizotinib in many cases. Herein, we analyzed 103 repeat biopsies from ALK-positive patients progressing on various ALK inhibitors...
October 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27360673/back-pain-in-a-junior-olympian-running-1848-june-2-2-20-pm-2-40-pm
#11
Julia L Iafrate, Karen L Newcomer
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27343442/acquired-resistance-to-crizotinib-in-nsclc-with-met%C3%A2-exon-14-skipping
#12
Rebecca S Heist, Lecia V Sequist, Darrell Borger, Justin F Gainor, Ronald S Arellano, Long P Le, Dora Dias-Santagata, Jeffrey W Clark, Jeffrey A Engelman, Alice T Shaw, A John Iafrate
INTRODUCTION: MET proto-oncogene, receptor tyrosine kinase gene (MET) exon 14 skipping is a targetable alteration in lung cancer. Treatment with MET proto-oncogene, receptor tyrosine kinase inhibitor can cause dramatic responses in patients whose cancers have MET exon 14 skipping. Little is known, however, about acquired resistance in patients with MET exon 14 skipping. METHODS: Biopsy specimens obtained at baseline and at the time of progression for a patient being treated with crizotinib were compared using targeted next-generation sequencing to assess for mechanisms of resistance...
August 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27228285/a-circulating-mirna-assay-as-a-first-line-test-for-prostate-cancer-screening
#13
Evgeniya Sharova, Angela Grassi, Anna Marcer, Katia Ruggero, Francesco Pinto, Pierfrancesco Bassi, Paola Zanovello, Filiberto Zattoni, Donna M D'Agostino, Massimo Iafrate, Vincenzo Ciminale
BACKGROUND: Prostate cancer (PCa) screening currently relies on prostate-specific antigen (PSA) testing and digital rectal examination. However, recent large-scale studies have questioned the long-term efficacy of these tests, and biomarkers that accurately identify PCa are needed. METHODS: We analysed the levels of circulating microRNAs (miRNAs) in patients with elevated PSA who were diagnosed with either localised PCa (n=36) or benign prostatic hyperplasia (BPH, n=31) upon biopsy...
June 14, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27127954/resolving-the-extragalactic-%C3%AE-ray-background-above-50%C3%A2-gev-with-the-fermi-large-area-telescope
#14
M Ackermann, M Ajello, A Albert, W B Atwood, L Baldini, J Ballet, G Barbiellini, D Bastieri, K Bechtol, R Bellazzini, E Bissaldi, R D Blandford, E D Bloom, R Bonino, J Bregeon, R J Britto, P Bruel, R Buehler, G A Caliandro, R A Cameron, M Caragiulo, P A Caraveo, E Cavazzuti, C Cecchi, E Charles, A Chekhtman, J Chiang, G Chiaro, S Ciprini, J Cohen-Tanugi, L R Cominsky, F Costanza, S Cutini, F D'Ammando, A de Angelis, F de Palma, R Desiante, S W Digel, M Di Mauro, L Di Venere, A Domínguez, P S Drell, C Favuzzi, S J Fegan, E C Ferrara, A Franckowiak, Y Fukazawa, S Funk, P Fusco, F Gargano, D Gasparrini, N Giglietto, P Giommi, F Giordano, M Giroletti, G Godfrey, D Green, I A Grenier, S Guiriec, E Hays, D Horan, G Iafrate, T Jogler, G Jóhannesson, M Kuss, G La Mura, S Larsson, L Latronico, J Li, L Li, F Longo, F Loparco, B Lott, M N Lovellette, P Lubrano, G M Madejski, J Magill, S Maldera, A Manfreda, M Mayer, M N Mazziotta, P F Michelson, W Mitthumsiri, T Mizuno, A A Moiseev, M E Monzani, A Morselli, I V Moskalenko, S Murgia, M Negro, E Nuss, T Ohsugi, C Okada, N Omodei, E Orlando, J F Ormes, D Paneque, J S Perkins, M Pesce-Rollins, V Petrosian, F Piron, G Pivato, T A Porter, S Rainò, R Rando, M Razzano, S Razzaque, A Reimer, O Reimer, T Reposeur, R W Romani, M Sánchez-Conde, J Schmid, A Schulz, C Sgrò, D Simone, E J Siskind, F Spada, G Spandre, P Spinelli, D J Suson, H Takahashi, J B Thayer, L Tibaldo, D F Torres, E Troja, G Vianello, M Yassine, S Zimmer
The Fermi Large Area Telescope (LAT) Collaboration has recently released a catalog of 360 sources detected above 50 GeV (2FHL). This catalog was obtained using 80 months of data re-processed with Pass 8, the newest event-level analysis, which significantly improves the acceptance and angular resolution of the instrument. Most of the 2FHL sources at high Galactic latitude are blazars. Using detailed Monte Carlo simulations, we measure, for the first time, the source count distribution, dN/dS, of extragalactic γ-ray sources at E>50  GeV and find that it is compatible with a Euclidean distribution down to the lowest measured source flux in the 2FHL (∼8×10^{-12}  ph cm^{-2} s^{-1})...
April 15, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27106868/pan-cancer-analysis-of-copy-number-changes-in-programmed-death-ligand-1-pd-l1-cd274-associations-with-gene-expression-mutational-load-and-survival
#15
Jan Budczies, Michael Bockmayr, Carsten Denkert, Frederick Klauschen, Stefan Gröschel, Silvia Darb-Esfahani, Nicole Pfarr, Jonas Leichsenring, Maristela L Onozato, Jochen K Lennerz, Manfred Dietel, Stefan Fröhling, Peter Schirmacher, A John Iafrate, Wilko Weichert, Albrecht Stenzinger
Inhibition of the PD-L1 (CD274) - PD-1 axis has emerged as a powerful cancer therapy that prevents evasion of tumor cells from the immune system. While immunohistochemical detection of PD-L1 was introduced as a predictive biomarker with variable power, much less is known about copy number alterations (CNA) affecting PD-L1 and their associations with expression levels, mutational load, and survival. To gain insight, we employed The Cancer Genome Atlas (TCGA) datasets to comprehensively analyze 22 major cancer types for PD-L1 CNAs...
August 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27076630/myc-driven-glycolysis-is-a-therapeutic-target-in-glioblastoma
#16
Kensuke Tateishi, A John Iafrate, Quan Ho, William T Curry, Tracy T Batchelor, Keith T Flaherty, Maristela L Onozato, Nina Lelic, Sudhandra Sundaram, Daniel P Cahill, Andrew S Chi, Hiroaki Wakimoto
PURPOSE: Deregulated Myc drives an oncogenic metabolic state, including pseudohypoxic glycolysis, adapted for the constitutive production of biomolecular precursors to feed rapid tumor cell growth. In glioblastoma, Myc facilitates renewal of the tumor-initiating cell reservoir contributing to tumor maintenance. We investigated whether targeting the Myc-driven metabolic state could be a selectively toxic therapeutic strategy for glioblastoma. EXPERIMENTAL DESIGN: The glycolytic dependency of Myc-driven glioblastoma was tested using (13)C metabolic flux analysis, glucose-limiting culture assays, and glycolysis inhibitors, including inhibitors of the NAD(+) salvage enzyme nicotinamide phosphoribosyl-transferase (NAMPT), in MYC and MYCN shRNA knockdown and lentivirus overexpression systems and in patient-derived glioblastoma tumorspheres with and without MYC/MYCN amplification...
September 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27064910/postoperative-quality-of-life-in-patients-with-ileal-neobladder-at-short-intermediate-and-long-term-follow-up
#17
Daniele D''Agostino, Marco Racioppi, Dario Pugliese, Mauro Ragonese, Luca Di Gianfrancesco, Alessio Filianoti, Giuseppe Palermo, Emanuele Belgrano, Salvatore Siracusano, Mauro Niero, Ciro Imbimbo, Massimo Iafrate, Walter Artibani, Maria Angela Cerruto, Renato Talamini, PierFrancesco Bassi
BACKGROUND: To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. PATIENTS AND METHODS: A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for the treatment of bladder cancer. One hundred seventy one patients who underwent radical cystectomy and creation of ileal orthotopic neobladder according to 'Vescica Ileale Padovana' between 2006 and 2011 have been analyzed...
2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27026089/colorectal-cancer-in-crohn-s-colitis-is-comparable-to-sporadic-colorectal-cancer
#18
Jochen K Lennerz, Kimberley W J van der Sloot, Long Phi Le, Julie M Batten, Jae Young Han, Kenneth C Fan, Corey A Siegel, Amitabh Srivastava, Do Youn Park, Jey-Hsin Chen, Bruce E Sands, Joshua R Korzenik, Robert D Odze, Dora Dias-Santagata, Darrell R Borger, Hamed Khalili, A John Iafrate, Gregory Y Lauwers
PURPOSE: It is now recognized that Crohn's disease (CD), similar to ulcerative colitis (UC), carries an up to 20-fold higher cancer risk, and the development of colorectal carcinoma (CRC) is a major long-term complication. Once CRC is present, molecular profiling is one of the components in selecting appropriate treatment strategies; however, in contrast to UC, genetic alterations in Crohn's colitis-associated CRC are poorly understood. METHODS: In a series of 227 patients with Crohn's colitis, we identified 33 cases of CRC (~14 %) and performed targeted mutational analysis of BRAF/KRAS/NRAS and determined microsatellite status as well as immunophenotype of the tumors...
May 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27022036/met-exon-14-skipping-in-non-small-cell-lung-cancer
#19
Rebecca S Heist, Hyo Sup Shim, Shalini Gingipally, Mari Mino-Kenudson, Long Le, Justin F Gainor, Zongli Zheng, Martin Aryee, Junfeng Xia, Peilin Jia, Hailing Jin, Zhongming Zhao, William Pao, Jeffrey A Engelman, A John Iafrate
BACKGROUND: Non-small cell lung cancers (NSCLCs) harboring specific genetic alterations can be highly sensitive to targeted therapies. MATERIALS AND METHODS: We performed a targeted rearrangement assay on 54 NSCLCs across all stages that were from patients who were never smokers and did not have driver mutations. Because MET exon 14 skipping was the most frequent alteration found, we surveyed the results for MET exon 14 skipping at Massachusetts General Hospital (MGH) since the inclusion of this alteration into our current molecular profiling panel...
April 2016: Oncologist
https://www.readbyqxmd.com/read/27015915/double-stage-venous-cannulation-combined-with-avalon%C3%A2-cannula-for-potential-prolongation-of-respiratory-ecmo-in-end-stage-pulmonary-disease
#20
Sébastien Colombier, René Prêtre, Manuel Iafrate, Lars Niclauss
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a treatment option to correct blood oxygenation in cases of severe respiratory failure. However, it is time-limited and, in cases of no- recovery, it is a bridge-to-lung transplant therapy. We report our experience of two patients waiting for emergency lung transplantation under VV-ECMO using the Avalon® cannula. Both presented signs of ECMO failure after prolonged support, i.e. increased hemolysis, decreased blood flow rate and increased negative pressure of the venous inflow line, leading to an inadequate systemic oxygenation...
October 2016: Perfusion
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