Gonzalo-Martín Pérez-Arana, David Almorza-Gomar, Maria-Angeles Mayo-Ossorio, Alonso Camacho Ramírez, María-Jesús Castro-Santiago, Amparo Valverde-Martínez, María-Dolores Casado-Maestre, Francisco Visiedo, Juan Carlos Bohórquez-Sierra, José-Arturo Prada-Oliveira
BACKGROUND: Among bariatric techniques, sleeve gastrectomy (SG) stands out owing to its efficiency. The role of the stomach as a secretory organ of many substances, such as gastrin, related to insulin secretion is well known. Gastrin induces insulin release in isolated pancreatic islets, limiting somatostatin-14 intraislet release, and has been associated with blood glucose level improvement in diabetic models after SG. SG involves gastric resection along the greater curvature. This study aimed to determine the role of gastrin in glucose metabolism improvement after SG with the aid of the gastrin antagonist netazepide...
April 2024: Journal of Gastrointestinal Surgery