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https://www.readbyqxmd.com/read/29452869/three-dimensional-printer-aided-casting-of-soft-custom-silicone-boluses-scsbs-for-head-and-neck-radiation-therapy
#1
Tsuicheng Chiu, Jun Tan, Mathew Brenner, Xuejun Gu, Ming Yang, Kenneth Westover, Tobin Strom, David Sher, Steve Jiang, Bo Zhao
PURPOSE: Custom tissue compensators provide dosimetric advantages for treating superficial or complex anatomy, but currently available fabrication technology is expensive or impractical for most clinical operations and yields compensators that are difficult for patients to tolerate. We aimed to develop an inexpensive, clinically feasible workflow for generating patient-specific, soft, custom silicone boluses (SCSBs) for head-and-neck (HN) radiation therapy. METHODS AND MATERIALS: We developed a method using 3-dimensional printed parts for generating SCSBs for the treatment of HN cancers...
November 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29452130/magnetic-combined-cross-linked-enzyme-aggregates-combi-cleas-for-cofactor-regeneration-in-the-synthesis-of-chiral-alcohol
#2
Erzheng Su, Yang Meng, Chenxi Ning, Xiaoqiang Ma, Senwen Deng
Magnetic Fe 3 O 4 nanoparticles were prepared and embedded into the Combi-CLEAs to produce the magnetic Combi-CLEAs in this work. The process for magnetic Combi-CLEAs preparation was optimized, and its properties were investigated. The optimum temperature, thermal stability and optimum pH of magnetic Combi-CLEAs were similar to those of Combi-CLEAs. The catalytic performance of magnetic Combi-CLEAs was tested with the biosynthesis of (S)-ethyl 4-chloro-3-hydroxybutyrate ((S)-CHBE). Magnetic Combi-CLEAs could tolerate higher substrate concentration in the biphasic system...
February 13, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29451773/surface-cation-segregation-and-chromium-deposition-on-the-double-perovskite-oxide-prbaco2o5-%C3%AE
#3
Bo Wei, Michael Schroeder, Manfred Martin
The surface chemistry and the Cr tolerance ability of oxygen electrodes play a vital role in the performance and long-term stability of solid oxide cells (SOCs). In this paper, the surface cation segregations on the double perovskite oxide PrBaCo2O5+δ (PBCO) and its relationship with Cr deposition are reported. During high temperature annealing in an O2 atmosphere, the elements Ba and Co diffuse out of the lattice and form many BaO and Co3O4 precipitates on the surface, mainly located at grain boundaries. In the presence of volatile Cr species, the observation of BaCrO4 but not CoCr2O4 on a segregated PBCO surface reveals that the Cr deposition preferentially takes place on segregated BaO rather than on Co3O4 precipitates...
February 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29450942/multivariate-analysis-of-cytokine-profiles-in-pregnancy-complications
#4
Fawaz Azizieh, Kamaludin Dingle, Raj Raghupathy, Kjell Johnson, Jacob VanderPlas, Ali Ansari
PROBLEM: The immunoregulation to tolerate the semiallogeneic fetus during pregnancy includes a harmonious dynamic balance between anti- and pro-inflammatory cytokines. Several earlier studies reported significantly different levels and/or ratios of several cytokines in complicated pregnancy as compared to normal pregnancy. However, as cytokines operate in networks with potentially complex interactions, it is also interesting to compare groups with multi-cytokine data sets, with multivariate analysis...
March 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29448053/biomarkers-of-operational-tolerance-following-kidney-transplantation-the-immune-tolerance-network-studies-of-spontaneously-tolerant-kidney-transplant-recipients
#5
REVIEW
Kenneth A Newell, Andrew B Adams, Laurence A Turka
Studies of kidney transplant recipients who have developed spontaneous and sustained tolerance have revealed an association with B cells. Unexpectedly tolerant individuals are characterized by increased numbers and frequencies of B cells in the blood and increased expression of genes associated with B cells in the blood and urine. Comparisons of the B cell repertoires of tolerant individuals and those receiving immunosuppression reveal that not only are the B cells more numerous but developmental differences result in a repertoire comprised of more naïve and transitional B cells in the tolerant cohort...
February 12, 2018: Human Immunology
https://www.readbyqxmd.com/read/29444576/-fractures-of-the-fifth-metatarsal-base
#6
K Bušková, D Kuběnová, M Tuček
Fractures of the fifth metatarsal base are among the most common fractures of the foot. They are typically caused by indirect violence during sports activities. This region is also a site where stress fractures occur frequently. Diagnosis is based on the patients medical history, clinical examination and imaging methods. The fundamental imaging method is radiography of the foot in three views. MRI is used primarily for early diagnosis of stress fractures. CT examination is beneficial mainly in complex foot injuries, in order to rule out associated fractures...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29443962/a-programmable-two-qubit-quantum-processor-in-silicon
#7
T F Watson, S G J Philips, E Kawakami, D R Ward, P Scarlino, M Veldhorst, D E Savage, M G Lagally, Mark Friesen, S N Coppersmith, M A Eriksson, L M K Vandersypen
Now that it is possible to achieve measurement and control fidelities for individual quantum bits (qubits) above the threshold for fault tolerance, attention is moving towards the difficult task of scaling up the number of physical qubits to the large numbers that are needed for fault-tolerant quantum computing. In this context, quantum-dot-based spin qubits could have substantial advantages over other types of qubit owing to their potential for all-electrical operation and ability to be integrated at high density onto an industrial platform...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29443390/tolerance-limits-and-methodologies-for-imrt-measurement-based-verification-qa-recommendations-of-aapm-task-group-no-218
#8
Moyed Miften, Arthur Olch, Dimitris Mihailidis, Jean Moran, Todd Pawlicki, Andrea Molineu, Harold Li, Krishni Wijesooriya, Jie Shi, Ping Xia, Nikos Papanikolaou, Daniel A Low
PURPOSE: Patient-specific IMRT QA measurements are important components of processes designed to identify discrepancies between calculated and delivered radiation doses. Discrepancy tolerance limits are neither well defined nor consistently applied across centers. The AAPM TG-218 report provides a comprehensive review aimed at improving the understanding and consistency of these processes as well as recommendations for methodologies and tolerance limits in patient-specific IMRT QA. METHODS: The performance of the dose difference/distance-to-agreement (DTA) and γ dose distribution comparison metrics are investigated...
February 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29443031/ultrasound-cyclo-plasty-in-eyes-with-glaucoma
#9
Giuseppe Giannaccare, Stefano Sebastiani, Emilio C Campos
Glaucoma is a chronic disease caused by the progressive degeneration of the optical nerve fibers, resulting in decreased visual field that can lead to severe visual impairment, and eventually blindness. This manuscript describes a simple, surgeon-friendly, non-incisional technique, named Ultrasound Cyclo Plasty (UCP), for reducing intraocular pressure (IOP) in glaucoma patients. The technique determines a selective coagulation necrosis of the ciliary body; in addition, the stimulation of supra-choroidal and trans-scleral portions of the uveo-scleral outflow pathway has been recently proposed...
January 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441778/nickel-catalyzed-phosphine-free-direct-n-alkylation-of-amides-with-alcohols
#10
Jagadish Das, Debasis Banerjee
Herein, we developed an operational simple, practical and selective Ni-catalyzed synthesis of secondary amides. Application of renewable alcohols, earth-abundant and non-precious nickel catalyst enable the transformations, releasing water as by product. The catalytic system is tolerant to variety of functional groups including nitrile, allylic ether and alkene and could be extended to the synthesis of bis-amide, antiemetic drug Tigan and dopamine D2 receptor antagonist Itopride. Preliminary mechanistic studies, revealed the participation of benzylic C-H bond in the rate-determining step...
February 14, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29441191/studying-the-effects-of-primary-arthroplasty-on-post-treatment-results-among-elderly-patients-with-pertrochanteric-fracture
#11
Mostafa Shahrezaee, Mohammad Ali Okhovatpour, Mohammad Banasiri, Seyyed Reza Sharifzadeh
Various therapeutic methods are available to treat patients with intertrochantric fracture, which is usually caused by falling down. This complication is usually observed among the elderly, particularly old women. The choice of the proper therapeutic method depends on many factors including patient's condition, type of fracture, and the amount of movement. Hip arthroplasty is one of these therapeutic methods, which have certain advantages and disadvantages. Immediate resumption of walking with the ability of weight toleration and absence of complications such as aseptic necrosis are some advantages of this method...
January 8, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29432257/progression-of-living-liver-donation-worldwide
#12
Trevor L Nydam, Mettu Srinivas Reddy, Elizabeth A Pomfret, Mohamed Rela
PURPOSE OF REVIEW: Living donor liver transplantation (LDLT) has developed into a well tolerated and viable option when deceased donor transplantation is not available. Transplant and advanced hepatobiliary surgeons from around the world have performed living donor hepatectomies consistently for decades with acceptable donor outcomes. However, optimizing the preoperative workup, donor selection, operative technique, and perioperative care will improve these outcomes. This manuscript reviews recent worldwide literature for the living liver donor...
February 9, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29427591/steroid-regulation-an-overlooked-aspect-of-tolerance-and-chronic-rejection-in-kidney-transplantation
#13
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Sonia Norris, Yogesh Kamra, Rachel Hilton
Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared...
February 7, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29426959/acute-effect-of-inhaled-iloprost-in-children-with-pulmonary-arterial-hypertension-associated-with-simple-congenital-heart-defects
#14
Qiangqiang Li, Konstantinos Dimopoulos, Chen Zhang, Yan Zhu, Qian Liu, Hong Gu
Inhaled prostacyclin analogue iloprost is currently utilized in adult patients with pulmonary arterial hypertension (PAH), but little information is available on its use in the pediatric population. This study evaluated the safety and acute haemodynamic effects of inhaled iloprost in children with PAH associated with congenital heart disease (CHD). Children with PAH-CHD who underwent cardiac catheterization and iloprost administration in our catheter laboratory between June 2007 and October 2015 were included...
February 9, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29425320/treatment-for-uncomplicated-plasmodium-falciparum-malaria-in-french-soldiers-deployed-in-sub-saharan-africa-gaps-between-policy-and-field-practice
#15
Anne Perisse, Guillaume Velut, Emilie Javelle, Gwion Loarer, Remy Michel, F Simon
Background: Malaria prevention and treatment are big challenges for the French forces deployed in sub-Saharan Africa. Since December 2013, 1,800 French soldiers have been deployed at any one time in the Central African Republic in the framework of "Operation Sangaris" and European Union Force (EUFOR). Over the 2014-2015 period, about 500 cases of malaria were notified in these troops during the operation or after their return (annual incidence: 13.4 p.100 person-year). The recommendation to use dihydroartemisinin-piperaquine (DHA-PQ) as the first-line treatment for French soldiers suffering from uncomplicated Plasmodium falciparum malaria in endemic areas is not always followed in practice in the field by French military general practitioners (GPs)...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29421827/combining-various-methods-to-assess-insulin-sensitivity-in-nonobese-rat-after-sleeve-gastrectomy
#16
Dong Sun, Yanmin Wang, Meng Wei, Zongli Zhang, Sanyuan Hu
BACKGROUND: Sleeve gastrectomy (SG) procedure has been proved to improve insulin sensitivity and sustain anti-diabetic effects. Our aim is to co-use several methods to measure insulin sensitivity and investigate the effect of SG on hepatic and peripheral insulin sensitivity at early and long-term stages of postoperation. METHODS: Thirty 11-week-old male Goto-Kakizaki rats were divided into SG, sham-operated SG (SOSG), and control groups. They were observed before operation and for 36 weeks of postoperation...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29417958/comparison-of-impact-performance-between-youth-and-varsity-football-helmets
#17
David W Sproule, Steven Rowson
Current youth football helmets, intended for players under the age of 14 years old, are similar in design and are tested under the same standard as varsity football helmets. This study evaluated the impact performance of matched youth and adult varsity football helmets. Eight helmet models were evaluated using an impact pendulum, with a modified National Operating Committee on Standards for Athletic Equipment (NOCSAE) medium sized headform mounted on a Hybrid III 50th percentile neck. Four locations on the helmet shell at three impact velocities were tested for three trials, for a total of 576 impact tests...
December 2017: Proc Inst Mech Eng P J Sport Eng Technol
https://www.readbyqxmd.com/read/29417586/office-based-esophageal-dilation-in-head-and-neck-cancer-safety-feasibility-and-cost-analysis
#18
Rebecca J Howell, Melissa A Schopper, John Paul Giliberto, Ryan M Collar, Sid M Khosla
OBJECTIVE: To review experience, safety, and cost of office-based esophageal dilation in patients with history of head and neck cancer (HNCA). METHODS: The medical records of patients undergoing esophageal dilation in the office were retrospectively reviewed between August 2015 and May 2017. Patients were given nasal topical anesthesia. Next, a transnasal esophagoscopy (TNE) was performed. If the patient tolerated TNE, we proceeded with esophageal dilation using Seldinger technique with the CRE™ Boston Scientific (Boston Scientific Corp...
February 8, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29417049/stress-resilience-of-spermatozoa-and-blood-mononuclear-cells-without-prion-protein
#19
Malin R Reiten, Giulia Malachin, Elisabeth Kommisrud, Gunn C Østby, Karin E Waterhouse, Anette K Krogenæs, Anna Kusnierczyk, Magnar Bjørås, Clara M O Jalland, Liv Heidi Nekså, Susan S Røed, Else-Berit Stenseth, Frøydis D Myromslien, Teklu T Zeremichael, Maren K Bakkebø, Arild Espenes, Michael A Tranulis
The cellular prion protein PrPC is highly expressed in neurons, but also present in non-neuronal tissues, including the testicles and spermatozoa. Most immune cells and their bone marrow precursors also express PrPC. Clearly, this protein operates in highly diverse cellular contexts. Investigations into putative stress-protective roles for PrPC have resulted in an array of functions, such as inhibition of apoptosis, stimulation of anti-oxidant enzymes, scavenging roles, and a role in nuclear DNA repair. We have studied stress resilience of spermatozoa and peripheral blood mononuclear cells (PBMCs) derived from non-transgenic goats that lack PrPC (PRNPTer/Ter) compared with cells from normal (PRNP+/+) goats...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29416859/applying-realistic-medicine-to-intrathecal-opioid-utilisation-in-scotland-do-we-have-a-standardised-approach
#20
Robert Hart, Gordon Burns, Susan Smith
Intrathecal opioids (ITOs) are commonly administered as part of a multimodal anaesthetic strategy for a variety of surgical procedures. The evolution of laparoscopic surgical techniques has seen the popularity of ITOs increase as they are effective, well tolerated and lack the cardiovascular side effects associated with epidural infusions. The risk of delayed respiratory depression remains a concern; therefore, high-quality post-operative monitoring is vital. The evidence regarding the practicalities of ITO administration such as opioid dose, type, side effect prevalence and ideal post-operative care arrangements are sparse...
February 2018: British Journal of Pain
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