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operational tolerance

Jaime Hartless
Gay bars have long been understood as havens from heteronormativity. However, a shift towards greater LGBTQ tolerance has led to more heterosexual involvement in these once marginal places. Such shifts towards 'post-gay' identity politics have called into question the queerness of many LGBTQ-oriented social outlets. This paper illustrates how rhetorical marketing and aesthetic choices lead some venues to develop reputations as questionably queer spaces-reputations that are created and negotiated by patrons as they evaluate these venues' ultimate functionality in relation to their own increasingly uncertain ideals about the form and desirability of queer spaces...
June 21, 2018: Journal of Homosexuality
P G Genov, V Kh Timerbaev, N S Dolgasheva, A A Efanov, A A Grin', O Yu Rebrova
The risk factors for acute pain as well as chronic pain syndrome (CPS) in spine surgery have not been defined to date. PURPOSE: To define the prognostic parameters of acute pain severity and the risk of CPS in patients operated on for spinal diseases and injuries. MATERIAL AND METHODS: The study included 291 patients operated on for degenerative diseases and injuries of the spine at the Sklifosovsky Research Institute of Emergency Medicine in 2010-2016. Sociodemographic and clinical data and the psychological status of patients were evaluated...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Habib G Zalzal, Chadi A Makary, Raquel Evans, Stacy Giardina, Tracy Underwood, Aletha Rowlands, Hassan H Ramadan
OBJECTIVE: To determine whether we could reduce the time that patients undergoing tonsillectomy are observed postoperatively without decreasing the quality of care, which would eliminate the unnecessary use of resources to monitor those patients. STUDY DESIGN: Prospective cohort. METHODS: Patients undergoing tonsillectomy were recruited for the study prior to their operation. Each patient was then monitored in perianesthesia recovery until clinical indicators for discharge readiness were met (baseline respiratory function, afebrile, ambulation per age, adequate consciousness, absence of nausea/vomiting, adequate pain control, no active bleeding, fluid toleration)...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
Luca Laurenti, Attila Csikasz-Nagy, Marta Kwiatkowska, Luca Cardelli
Living systems are inherently stochastic and operate in a noisy environment, yet despite all these uncertainties, they perform their functions in a surprisingly reliable way. The biochemical mechanisms used by natural systems to tolerate and control noise are still not fully understood, and this issue also limits our capacity to engineer reliable, quantitative synthetic biological circuits. We study how representative models of biochemical systems propagate and attenuate noise, accounting for intrinsic as well as extrinsic noise...
June 19, 2018: Biophysical Journal
Robin Emsley, Isaac Nuamah, Srihari Gopal, David Hough, W Wolfgang Fleischhacker
BACKGROUND: It has been proposed that relapse rates after antipsychotic discontinuation may be artificially inflated and that some of these symptom recurrences may be due to rebound or withdrawal phenomena rather than due to illness recurrence. METHODS: Post hoc analysis of data from a relapse-prevention study (conducted from March 2005 to February 2007) of paliperidone palmitate once-monthly (PP1M) versus placebo was conducted to compare the nature of operationally defined relapse events in schizophrenia patients (diagnosed by DSM-IV criteria) experiencing relapses after randomization to placebo (n = 97) with those in patients receiving maintenance PP1M treatment (n = 36)...
June 19, 2018: Journal of Clinical Psychiatry
F Tatulli, A Delcuratolo, A Caraglia, A Notarnicola, F P N Carbone, A Caputi
INTRODUCTION: Laparoscopy is perceived as the state-of-the-art technique for a wide variety of operations but is contraindicated by comorbidities such as respiratory diseases. We present the case of a patient affected by asthma who underwent a successful three-trocar low-pressure pneumoperitoneum under spinal anesthesia. CASE REPORT: A 58 year-old male with symptomatic gallstones had partly-controlled asthma and respiratory allergies. Potential bronchospasm was avoided by a less invasive laparoscopic technique...
May 2018: Il Giornale di Chirurgia
Thomas L Powell, Charles D Koven, Daniel J Johnson, Boris Faybishenko, Rosie A Fisher, Ryan G Knox, Nate G McDowell, Richard Condit, Stephen P Hubbell, S Joseph Wright, Jeffrey Q Chambers, Lara M Kueppers
The fate of tropical forests under climate change is unclear as a result, in part, of the uncertainty in projected changes in precipitation and in the ability of vegetation models to capture the effects of drought-induced mortality on aboveground biomass (AGB). We evaluated the ability of a terrestrial biosphere model with demography and hydrodynamics (Ecosystem Demography, ED2-hydro) to simulate AGB and mortality of four tropical tree plant functional types (PFTs) that operate along light- and water-use axes...
June 20, 2018: New Phytologist
Jacob A Sambursky, Sundeep Kumar, Molly Orban, Esteban Janolo, Vladimir Neychev
Pneumoperitoneum is described as the presence of free air in the peritoneal cavity. In the majority of cases, it is the manifestation of abdominal viscus perforation, requiring an emergent surgical exploration. In rare cases, however, no evidence of perforation of the gastrointestinal or genitourinary tracts can be found at exploration, and in such cases, the pneumoperitoneum is referred to as non-surgical pneumoperitoneum. We present a case of an 87-year-old man who developed a non-surgical pneumoperitoneum in the setting of gram-negative sepsis...
April 17, 2018: Curēus
M H Zhou, Y L Zhao, Y J Zhang, S T Zhang
Objective: To investigate efficacy of individualized nasal cavity ventilation expansion techniques for OSAHS patients with nasal obstruction. Method: One hundred and twelve OSAHS patients with nasal obstruction were included in this study. Nasal cavity ventilation expansion techniques were performed. Every patient took the examination of acoustic rhinometry, nasal respiration volume, rhinomanometry and polysomnography, and filled VAS of nasal obstruction and Epworth Sleep Scores(ESS) before surgery and three months after surgery...
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Jinpeng Du, Chaojie Hu, Jie Bai, Miaomiao Peng, Qingbo Wang, Ning Zhao, Yu Wang, Guobin Wang, Kaixiong Tao, Geng Wang, Zefeng Xia
BACKGROUND: The unique effects of gastric resection after vertical sleeve gastrectomy (VSG) on type 2 diabetes mellitus remain unclear. This work aimed to investigate the effects of VSG on gastric leptin expression and intestinal glucose absorption in high-fat diet-induced obesity. METHODS: Male C57BL/6J mice were fed a high-fat diet (HFD) to induce obesity. HFD mice were randomized into VSG and sham-operation groups, and the relevant parameters were measured at 8 weeks postoperation...
June 18, 2018: Obesity Surgery
Carla E Rosenfeld, Bruce R James, Cara Santelli
Mining and other industrial activities worldwide have resulted in Se-enriched surface soils, which pose risks to human and environmental health. Although not well studied, microbial activity can alter Se bioavailability and distribution, even in oxic environments. We used high throughput sequencing to profile bacterial and fungal communities inhabiting mine soils in southeastern Idaho, comparing mined and unmined locations within two reclaimed phosphate mine areas containing variable Se concentrations. The goal was to determine whether microbial communities differed in (i) different mines, (ii) mined areas compared to unmined areas, and (iii) varying soil Se concentrations...
June 18, 2018: Applied and Environmental Microbiology
Guan-Hui Zhou, Jun Han, Jun-Hui Sun, Yue-Lin Zhang, Tan-Yang Zhou, Chun-Hui Nie, Tong-Yin Zhu, Sheng-Qun Chen, Bao-Quan Wang, Zi-Niu Yu, Hong-Liang Wang, Li-Ming Chen, Wei-Lin Wang, Shu-Sen Zheng
BACKGROUND: This study aimed to investigate the efficacy and safety of drug eluting beads transarterial chemoembolization (DEB-TACE) treatment by CalliSpheres® in Chinese patients with hepatocellular carcinoma (HCC) as well as the predicting factors for response. METHODS: 99 patients with HCC were consecutively enrolled in this study. All participants were treated by CalliSpheres® DEB-TACE. Clinical response was evaluated according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria...
June 8, 2018: BMC Cancer
Katja Venborg Pedersen, Asbjørn Mohr Drewes, Ole Graumann, Susanne Sloth Osther, Anne Estrup Olesen, Lars Arendt-Nielsen, Palle Jørn Sloth Osther
Background and purpose Visceral and somatic afferents activate the same neuronal structures in the central nervous system. Assessing somatosensory function and trophic changes in the referred pain area may therefore indirectly increase information on mechanisms involved in painful visceral diseases. The aim of this study was to evaluate the sensory and trophic changes in the flank corresponding to the referred pain area in patients with kidney stone disease. Methods A total of 24 patients with unilateral pain-causing kidney stone disease were studied before and after endoscopic percutaneous kidney stone surgery...
December 29, 2017: Scandinavian Journal of Pain
Jarkko Kalliomäki, Märta Segerdahl, Lynn Webster, Annika Reimfelt, Karin Huizar, Peter Annas, Rolf Karlsten, Hans Quiding
Aim To evaluate the analgesic efficacy of AZD1940, a novel peripherally acting cannabinoid CB1/CB2 receptor agonist, in patients undergoing third molar surgical removal. Methods This was a randomized, double-blind, placebo-controlled study in patients scheduled for surgical removal of an impacted lower third molar. Patients received a single oral dose of 800 μg AZD1940, 500 mg naproxen or placebo 1.5 h before surgery. The dose of 800 μg AZD1940 was selected based on earlier data from a single dose study in man, in which it was identified as the highest well tolerated dose...
December 29, 2017: Scandinavian Journal of Pain
Si-Shun Yan, Lei Zhu, Jian-Heng Ye, Zhen Zhang, He Huang, Huiying Zeng, Chao-Jun Li, Yu Lan, Da-Gang Yu
The first ruthenium-catalyzed umpolung carboxylation of hydrazones with CO2 to generate important aryl acetic acids is reported. Besides aldehyde hydrazones, a variety of ketone hydrazones, which have not been successfully applied in previous umpolung reactions with other reactive electrophiles, also show high reactivity and selectivity under mild conditions. Moreover, this operationally simple protocol features good functional group tolerance, is readily scalable, and offers easy derivation of important structures, including bioactive felbinac and adiphenine...
June 7, 2018: Chemical Science
David J Goldberg, Victor Zak, Bryan H Goldstein, Brian W McCrindle, Shaji C Menon, Kurt R Schumacher, R Mark Payne, Jonathan Rhodes, Kimberly E McHugh, Daniel J Penny, Felicia Trachtenberg, Michelle S Hamstra, Marc E Richmond, Peter C Frommelt, Matthew D Files, James L Yeager, Victoria L Pemberton, Mario P Stylianou, Gail D Pearson, Stephen M Paridon
The Fontan operation creates a circulation characterized by elevated central venous pressure and low cardiac output. Over time, these characteristics result in a predictable and persistent decline in exercise performance that is associated with an increase in morbidity and mortality. A medical therapy that targets the abnormalities of the Fontan circulation might, therefore, be associated with improved outcomes. Udenafil, a phosphodiesterase type 5 inhibitor, has undergone phase I/II testing in adolescents who have had the Fontan operation and has been shown to be safe and well tolerated in the short term...
July 2018: American Heart Journal
Cenk Yardımcı, Taylan Önyay, Kamil S İnal, Deniz B Özbakır, Ahmet Özak
OBJECTIVE:  This article presents a novel surgical technique in the management of open complete talocrural luxations and evaluates the results, and clinical benefits with its routine clinical utilization. STUDY DESIGN:  Retrospective study. ANIMALS:  Seventeen medium- or large-breed client-owned dogs of different breed, age and sex with complete talocrural luxations and radiographic follow-up of at least 24 weeks duration. METHOD:  Selective talocrural arthrodesis was performed by using a hybrid transarticular external skeletal fixator frame...
June 16, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Shabbir Hussain Merchant, Sheng-Han Kuo, Yu Qiping, Linda Winfield, Guy McKhann, Sameer Sheth, Seth L Pullman, Blair Ford
OBJECTIVE: To identify pre-operative clinical and computerized spiral analysis characteristics that may help ascertain which patients with Essential Tremor (ET) will exhibit 'early tolerance' to ventral intermediate nucleus of thalamus (Vim) deep brain stimulation (DBS). METHODS: Identification of comparative characteristics of defined cases of 'early tolerance' versus patients with sustained satisfactory response treated with Vim DBS surgery for medically-refractory ET, based on retrospective chart review by a clinician blinded to the findings of computerized spiral analysis...
June 5, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Kodavati Manohar, Doureradjou Peroumal, Narottam Acharya
Polη, a unique TLS DNA polymerase that promotes efficient bypass of UV-induced CPDs and cisplatin adducts, has not been explored in Candida species yet. Here we show that CaPolη plays a vital role in protecting Candida albicans genome from diverse array of DNA damaging agents, not limited to UV and cisplatin. Polη deficient strain did not exhibit any hyphal development in the presence of UV and cisplatin while the wild type strain profusely developed DNA damage induced filamentation. The polarized growth induced by HU and MMS was found to be Polη independent...
June 15, 2018: Molecular Microbiology
Laurent M Willems, Philipp S Reif, Andrea Spyrantis, Adriano Cattani, Thomas M Freiman, Volker Seifert, Marlies Wagner, Se-Jong You, Susanne Schubert-Bast, Sebastian Bauer, Karl Martin Klein, Felix Rosenow, Adam Strzelczyk
INTRODUCTION: Stereoelectroencephalography (sEEG) is a diagnostic procedure for patients with refractory focal epilepsies that is performed to localize and define the epileptogenic zone. In contrast to grid electrodes, sEEG electrodes are implanted using minimal invasive operation techniques without large craniotomies. Previous studies provided good evidence that sEEG implantation is a safe and effective procedure; however, complications in asymptomatic patients after explantation may be underreported...
June 13, 2018: Epilepsy & Behavior: E&B
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