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https://www.readbyqxmd.com/read/28636809/visible-light-driven-aza-ortho-quinone-methide-generation-enables-a-multicomponent-reaction
#1
Wen-Jing Xiao, Yi-Ying Liu, Xiao-Ye Yu, Miao-Maio Qiao, Xiaotian Qi, Jia-Rong Chen, De-Qing Shi
A visible light photoredox-catalyzed and radical-mediated strategy for the in situ generation of aza-ortho-quinone methides from readily accessible alkenylanilines and alkyl radical precursors has been accomplished for the first time. This protocol enables an efficient multicomponent cascade reaction of alkenylanilines, halides and sulfur ylides, and shows wide substrate scope and high functional group tolerance with respect to each component. Treatment of the initially formed cycloaddition products with a base leads to a convergent and streamlined synthesis of densely functionalized indoles in a single flask operation...
June 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28636366/oxygenation-via-c-h-c-c-bond-activation-with-molecular-oxygen
#2
Yu-Feng Liang, Ning Jiao
The selective oxidation of organic molecules is a fundamentally important component of modern synthetic chemistry. In the past decades, direct oxidative C-H and C-C bond functionalization has proved to be one of the most efficient and straightforward methods to synthesize complex products from simple and readily available starting materials. Among these oxidative processes, the use of molecular oxygen as a green and sustainable oxidant has attracted considerable attention because of its highly atom-economical, abundant, and environmentally friendly characteristics...
June 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28634703/isoperistaltic-versus-antiperistaltic-side-to-side-anastomosis-after-right-laparoscopic-hemicolectomy-for-cancer-isovanti-trial-study-protocol-for-a-randomised-clinical-trial
#3
N Ibañez, J Abrisqueta, J Luján, Q Hernández, P Parrilla
BACKGROUND: It is believed that loosing ileocecal valve is well tolerated in patients who do not have short bowel syndrome or Crohn disease. From the hypothesis of colonic peristalsis and transit is regulated by that ileocecal valvular mechanism, we try to find out if the creation of a new pseudo-valvular mechanism as antiperistaltic anastomosis could be considered after right hemicolectomy can cause any short- or long-term changes in gastrointestinal habits. PURPOSE: The purpose of the study at primary endpoint is to compare early (occurring within 30 days of surgery) and late (occurring during the follow-up) postoperative complications between both groups The purpose of the study at secondary endpoint is to compare intraoperative and postoperative events between experimental and control groups in terms of operating time, first oral tolerance day, first flatus and faeces, length of hospital stay and orocecal transit; comparing rates of gastrointestinal life quality and comparing mortality rates between both groups...
June 21, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28631846/visible-light-mediated-dual-decarboxylative-coupling-of-redox-active-esters-with-alpha-beta-unsaturated-carboxylic-acids
#4
Xin-Hua Duan, Jin-Jiang Zhang, Jun-Cheng Yang, Li-Na Guo
An efficient visible-light-induced decarboxylative coupling between alpha, beta-unsaturated carboxylic acids and alkyl N-hydroxyphthalimide esters has been developed. A wide range of redox-active esters derived from aliphatic carboxylic acids (1o, 2o and 3o) proved viable in this dual decarboxylation process, affording a broad scope of substituted alkenes in moderate to excellent yields with good E/Z selectivities. This redox-neutral procedure was highlighted by its mild conditions, operational simplicity, easy accessibility of carboxylic acids, and excellent functional-group tolerance...
June 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28630722/hip-arthroscopy-protocol-expert-opinions-on-post-operative-weight-bearing-and-return-to-sports-guidelines
#5
Ehud Rath, Zachary T Sharfman, Matan Paret, Eyal Amar, Michael Drexler, Nicolas Bonin
The objectives of this study are to survey the weight-bearing limitation practices and delay for returning to running and impact sports of high volume hip arthroscopy orthopedic surgeons. The study was designed in the form of expert survey questionnaire. Evidence-based data are scares regarding hip arthroscopy post-operative weight-bearing protocols. An international cross-sectional anonymous Internet survey of 26 high-volume hip arthroscopy specialized surgeons was conducted to report their weight-bearing limitations and rehabilitation protocols after various arthroscopic hip procedures...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630086/psychosocial-therapy-for-parkinson-s-related-dementia-study-protocol-for-the-invest-randomised-controlled-trial
#6
Sheree A McCormick, Kathryn R McDonald, Sabina Vatter, Vasiliki Orgeta, Ellen Poliakoff, Sarah Smith, Monty A Silverdale, Bo Fu, Iracema Leroi
INTRODUCTION: Parkinson's disease (PD) with mild cognitive impairment (MCI-PD) or dementia (PDD) and dementia with Lewy bodies (DLB) are characterised by motor and 'non-motor' symptoms which impact on quality of life. Treatment options are generally limited to pharmacological approaches. We developed a psychosocial intervention to improve cognition, quality of life and companion burden for people with MCI-PD, PDD or DLB. Here, we describe the protocol for a single-blind randomised controlled trial to assess feasibility, acceptability and tolerability of the intervention and to evaluate treatment implementation...
June 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/28628979/the-short-and-long-term-effects-of-mn-2-on-biogranule-based-anaerobic-ammonium-oxidation-anammox
#7
Jia-Jia Xu, Zheng-Zhe Zhang, Qian-Qian Chen, Zheng-Quan Ji, Ying-Hong Zhu, Ren-Cun Jin
The short- and long-term effects of Mn(2+) on the performance of anaerobic ammonium oxidation (anammox) granules were investigated in the present study. Anammox activity was determined at various Mn(2+) concentrations in batch assays, and the 50% inhibition concentration value was determined to be 7.33mgL(-1). However, no obvious deterioration of reactor performance was observed during the 150-day continuous-flow operation, and the nitrogen removal efficiency of the test reactor (R1) fluctuated between 91% and 92% as the Mn(2+) concentration was increased from 1 to 200mgL(-1)...
June 14, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28628748/does-young-age-really-put-the-heart-at-risk
#8
Michael P Belanger, Luke Yang Tan, Carin Wittnich
Despite significant advances in the management and treatment of heart disease in children, there continue to be patients who have worse outcomes than might be expected. A number of risk factors that could be responsible have been identified. Evidence based findings will be reviewed including whether young age and/or reduced body weight exacerbate these responses. For example, newborn children undergoing congenital cardiac surgery are known to have worse outcomes than older children. Evidence exists that newborn hearts do not tolerate ischemia as well as adults; developing irreversible injury sooner and exhibiting at risk metabolic profiles...
June 19, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28626466/identification-characterization-and-functional-validation-of-drought-responsive-micrornas-in-subtropical-maize-inbreds
#9
Jayaraman Aravind, Sharma Rinku, Banduni Pooja, Mittal Shikha, Shiriga Kaliyugam, Mallana Gowdra Mallikarjuna, Arun Kumar, Atmakuri Ramakrishna Rao, Thirunavukkarasu Nepolean
MicroRNA-mediated gene regulation plays a crucial role in controlling drought tolerance. In the present investigation, 13 drought-associated miRNA families consisting of 65 members and regulating 42 unique target mRNAs were identified from drought-associated microarray expression data in maize and were subjected to structural and functional characterization. The largest number of members (14) was found in the zma-miR166 and zma-miR395 families, with several targets. However, zma-miR160, zma-miR390, zma-miR393, and zma-miR2275 each showed a single target...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#10
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28625534/predictors-of-urinary-and-rectal-toxicity-after-external-conformed-radiation-therapy-in-prostate-cancer-correlation-between-clinical-tumour-and-dosimetric-parameters-and-radical-and-postoperative-radiation-therapy
#11
C M Martínez-Arribas, C González-San Segundo, P Cuesta-Álvaro, F A Calvo-Manuel
OBJECTIVE: To determine rectal and urinary toxicity after external beam radiation therapy (EBRT), assessing the results of patients who undergo radical or postoperative therapy for prostate cancer (pancreatic cancer) and their correlation with potential risk factors. METHOD: A total of 333 patients were treated with EBRT. Of these, 285 underwent radical therapy and 48 underwent postoperative therapy (39 cases of rescue and 9 of adjuvant therapy). We collected clinical, tumour and dosimetric variable to correlate with toxicity parameters...
June 15, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28618137/the-impact-of-aspiration-pneumonia-and-nasogastric-feeding-on-clinical-outcomes-in-stroke-patients-a-retrospective-cohort-study
#12
Maria Schwarz, Anne Coccetti, Allison Murdoch, Elizabeth Cardell
AIMS AND OBJECTIVES: To determine presence of clinical complications related to dysphagia and to explore their operational outcomes. BACKGROUND: Dysphagia is a common complication of stroke. The management of post stroke dysphagia is multi-disciplinary with nurses playing a key role in screening for dysphagia risk, monitoring tolerance of food and fluids and checking for the development of complications such as fever, dehydration and change in medical status. Dysphagia often results in further complications including aspiration pneumonia and the need for nasogastric feeding...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28616936/encephaloduroateriosynangiosis-edas-in-the-management-of-moyamoya-syndrome-in-children-with-sickle-cell-disease
#13
Alexander Alamri, Pennylouise Hever, Jebet Cheserem, Catia Gradil, Sanj Bassi, Christos M Tolias
BACKGROUND: Encephalo-duro-arterio-synangiosis (EDAS) in Moyamoya syndrome (MMS) treatment has been well described in the literature, however in MMS caused by sickle cell anaemia (SCA), EDAS use remains controversial with poor long-term follow-up. We present a case-series of SCA patients who have undergone EDAS for SCA-related MMS and describe their post-operative course as well as provide a literature review of the role of EDAS in the treatment of sickle cell anaemia. METHODS: A retrospective review of all the paediatric EDAS procedures conducted in our institution for SCA from 2007 to 2015...
June 15, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28616278/management-of-the-vertebral-artery-during-thoracic-endovascular-aortic-repair-with-coverage-of-the-left-subclavian-artery
#14
Jian Zhu, Er-Ping Xi, Shui-Bo Zhu, Gui-Lin Yin, Rong-Ping Wang, Yu Zhang
BACKGROUND: The application of thoracic endovascular aortic repair (TEVAR), a minimally invasive operation, in the aortic arch has been a challenge of cardiovascular surgery in recent years. This study aimed to investigate management of the vertebral artery with coverage of the left subclavian artery (LSA) during TEVAR. METHODS: From January 2007 to September 2014 in the Department of Cardiothoracic Surgery at Wuhan General Hospital of Guangzhou Military Region, 160 patients underwent LSA closure or partial coverage during TEVAR of an aortic lesion near the LSA...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28614619/direct-and-stereospecific-synthesis-of-n-h-and-n-alkyl-aziridines-from-unactivated-olefins-using-hydroxylamine-o-sulfonic-acids
#15
Zhiwei Ma, Zhe Zhou, László Kürti
Herein we report a Rh(II)-catalyzed direct and stereospecific N-H- and N-alkyl aziridination of olefins that uses hydroxylamine-O-sulfonic acids as inexpensive, readily available and nitro group-free aminating reagents. Unactivated olefins, featuring a wide range of functional groups, are converted to the corresponding N-H or N-alkyl aziridines in good to excellent yields. This operationally simple, scalable transformation proceeds efficiently at ambient temperature and is tolerant towards oxygen and trace moisture...
June 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28614590/chronic-ethanol-during-adolescence-impacts-corticolimbic-dendritic-spines-and-behavior
#16
Nicholas J Jury, Gabrielle A Pollack, Meredith J Ward, Jessica L Bezek, Alexandra J Ng, Courtney R Pinard, Hadley C Bergstrom, Andrew Holmes
BACKGROUND: Risk for alcohol use disorders (AUDs) in adulthood is linked to alcohol drinking during adolescence, but understanding of the neural and behavioral consequences of alcohol exposure during adolescence remains incomplete. Here, we examined the neurobehavioral impact of adolescent chronic intermittent EtOH (CIE) vapor exposure in mice. METHODS: C57BL/6J-background Thy1-EGFP mice were CIE-exposed during adolescence or adulthood and examined, as adults, for alterations in the density and morphology of dendritic spines in infralimbic (IL) cortex, prelimbic (PL) cortex, and basolateral amygdala (BLA)...
June 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28614469/assessing-the-feasibility-of-the-healthy-life-in-suriname-study-using-advanced-hemodynamics-to-evaluate-cardiovascular-risk
#17
Jet Q Aartman, Frederieke S Diemer, Fares A Karamat, Evelien Bohte, Sergio M Baldew, Ameerani V Jarbandhan, Gert A van Montfrans, Glenn P Oehlers, Lizzy M Brewster
Objectives: To determine the feasibility of assessing population cardiovascular risk with advanced hemodynamics in the Healthy Life in Suriname (HELISUR) study. Methods: This was a preliminary study conducted in May - June 2012 using the Technical-Economic-Legal-Operational-Scheduling (TELOS) method to assess the feasibility of the HELISUR-a large-scale, cross-sectional population study of cardiovascular risk factors and disease in Suriname. Suriname, a middle-income country in South America with a population of mostly African and Asian ethnicity, has a high risk of cardiovascular disease...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28614334/all-optical-flip-flop-based-on-hybrid-square-rectangular-bistable-lasers
#18
Xiu-Wen Ma, Yong-Zhen Huang, Yue-De Yang, Hai-Zhong Weng, Fu-Li Wang, Min Tang, Jin-Long Xiao, Yun Du
A compact, simple, and bistable hybrid square-rectangular laser is experimentally demonstrated as an all-optical flip-flop memory. Controllable bistability is induced by two-mode competition, together with the saturable absorption at the square microcavity section. The all-optical set and reset operations are realized by injecting signal pulses at two-mode wavelengths, with the response times of 165 and 60 ps at the triggering pulse width of 100 ps and switching energies of 2.7 and 14.2 fJ, respectively...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28613342/a-novel-metal-free-amidosulfenylation-of-alkenes-leading-to-%C3%AE-azolyl-sulfides
#19
Kai Sun, Yunhe Lv, Zuodong Shi, Shiqiang Mu, Changhao Li, Xin Wang
A novel and environmentally benign method for C-S and C-N bond formation by the direct amidosulfenylation of alkenes has been developed under metal-free conditions. Various alkenes and azoles were transformed into the corresponding β-azolyl sulfides in ionic liquids. The wide substrate scope, good functional group tolerance, and ease of operation make this reaction attractive for the synthesis of nitrogen- and sulfur-containing molecules.
June 14, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28611568/two-anomalies-in-one-a-rare-case-of-an-intrahepatic-gallbladder-with-a-cholecystogastric-fistula
#20
Mohammad F Ali, David Friedel, Galina Levin
The gallbladder can be situated in a variety of anomalous positions. An intrahepatic gallbladder - the second most common ectopic location of the gallbladder - is one that is completely embedded within the liver parenchyma. Described in the literature as early as 1935, intrahepatic gallbladders predominantly result from a developmental anomaly but in some instances have been reported to be secondary to chronic inflammation. The significance of an intrahepatic gallbladder lies in the fact that 60% of the cases are associated with gallstones and may present a challenge for the general surgeon during cholecystectomy and other biliary operations in addition to causing misdiagnosis on imaging...
January 2017: Case Reports in Gastroenterology
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