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Mohamad Amer Alaiti, Anas Fares, Andrejs Erglis, Lemba Nshisso, Kashif Shaikh, Anthony E DeCicco, Marwan Nasif, Ahmad Alkhalil, Hüseyin Ince, William T Abraham, Daniel I Simon, Marco A Costa, Guilherme F Attizzani, Hiram G Bezerra
BACKGROUND: The Parachute is a novel percutaneously implanted ventricular partitioning device (VPD) that has emerged as a safe and feasible treatment option for patients with heart failure following anterior wall myocardial infarction. VPD efficacy is likely dependent on optimal device placement, but to date there are no published data examining the effect of device positioning on patient outcomes. METHODS AND RESULTS: We retrospectively identified 32 patients successfully implanted with the Parachute device, all of whom underwent cardiac computed tomography (CCT) at baseline and after 6 months of follow-up...
July 29, 2016: Catheterization and Cardiovascular Interventions
Esther Ngo Lemba Tom, Corine Girard-Thernier, Céline Demougeot
BACKGROUND: Chlorogenic acid (CGA), the main polyphenol contained in coffee, is a major contributor to dietary polyphenol intake. Few studies reported its anti-hypertensive properties but the mechanisms are still indefinite. PURPOSE: The present study assessed the direct effect of CGA in endothelium denuded or intact aortic rings from male Wistar rats and the mechanisms involved. METHODS/RESULTS: CGA induced a direct endothelium-dependent relaxation that was significantly reduced by L-NAME (10(-4)M), indomethacin (10(-5)M) and combination of apamin (10(-7)M) and charybdotoxin (10(-7)M)...
September 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Alok K Shah, Kim-Anh Lê Cao, Eunju Choi, David Chen, Benoît Gautier, Derek Nancarrow, David C Whiteman, Peter R Baker, Karl R Clauser, Robert J Chalkley, Nicholas A Saunders, Andrew P Barbour, Virendra Joshi, Michelle M Hill
This data article describes serum glycoprotein biomarker discovery and qualification datasets generated using lectin magnetic bead array (LeMBA) - mass spectrometry techniques, "Serum glycoprotein biomarker discovery and qualification pipeline reveals novel diagnostic biomarker candidates for esophageal adenocarcinoma" [1]. Serum samples collected from healthy, metaplastic Barrett׳s esophagus (BE) and esophageal adenocarcinoma (EAC) individuals were profiled for glycoprotein subsets via differential lectin binding...
June 2016: Data in Brief
Reza Farzinebrahimi, Rosna Mat Taha, Kamaludin A Rashid, Bakrudeen Ali Ahmed, Mahmoud Danaee, Shahril Efzueni Rozali
Leaf, seed, and tuber explants of C. latifolia were inoculated on MS medium supplemented with various concentrations of BAP and IBA, alone or in combinations, to achieve in vitro plant regeneration. Subsequently, antioxidant and antibacterial activities were determined from in vitro and in vivo plant developed. No response was observed from seed culture on MS media with various concentrations of PGRs. The highest percentage of callus was observed on tuber explants (94%) and leaf explants (89%) when cultured on MS media supplemented with IBA in combination with BAP...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Sujit D Rathod, Ian M Timæus, Richard Banda, Kusanthan Thankian, Roma Chilengi, Andrew Banda, Musonda Lemba, Jeffrey S A Stringer, Benjamin H Chi
OBJECTIVES: To measure the sex-specific and community-specific mortality rates for adults in Lusaka, Zambia, and to identify potential individual-level, household-level and community-level correlates of premature mortality. We conducted 12 survey rounds of a population-based cross-sectional study between 2004 and 2011, and collected data via a structured interview with a household head. SETTING: Households in Lusaka District, Zambia, 2004-2011. PARTICIPANTS: 43,064 household heads (88% female) who enumerated 123,807 adult household members aged between 15 and 60 years...
2016: BMJ Open
Chun-Ho Yun, Jui-Peng Tsai, Cheng-Ting Tsai, Greta S P Mok, Jing-Yi Sun, Chung-Lieh Hung, Tung-Hsin Wu, Wu-Ta Huang, Fei-Shih Yang, Jason Jeun-Shenn Lee, Ricardo C Cury, Anas Fares, Lemba Dina Nshisso, Hiram G Bezerra
BACKGROUND: 3 T MRI has been adopted by some centers as the primary choice for assessment of myocardial perfusion over conventional 1.5 T MRI. However, there is no data published on the potential additional value of incorporating semi-quantitative data from 3 T MRI. This study sought to determine the performance of qualitative 3 T stress magnetic resonance myocardial perfusion imaging (3 T-MRMPI) and the potential incremental benefit of using a semi-quantitative perfusion technique in patients with suspected coronary artery disease (CAD)...
2015: BMC Cardiovascular Disorders
Alok K Shah, Kim-Anh Lê Cao, Eunju Choi, David Chen, Benoît Gautier, Derek Nancarrow, David C Whiteman, Nicholas A Saunders, Andrew P Barbour, Virendra Joshi, Michelle M Hill
We report an integrated pipeline for efficient serum glycoprotein biomarker candidate discovery and qualification that may be used to facilitate cancer diagnosis and management. The discovery phase used semi-automated lectin magnetic bead array (LeMBA)-coupled tandem mass spectrometry with a dedicated data-housing and analysis pipeline; GlycoSelector ( The qualification phase used lectin magnetic bead array-multiple reaction monitoring-mass spectrometry incorporating an interactive web-interface, Shiny mixOmics (http://mixomics-projects...
November 2015: Molecular & Cellular Proteomics: MCP
Mida Kautako-Kiambi, Mathilde B Ekila, Smith Kama-Lemba, Roger Wumba, Michel N Aloni
Aims. To determine the prevalence of HIV, the level of sexual risk for HIV, and determinants of VCT attendance among adult population living in a rural area. Methods. A cross-sectional study was conducted in Mbanza-Ngungu, Democratic Republic of the Congo. An anonymous questionnaire was designed to extract relevant data. Results. In our cohort, 69% were respondents of more than 24 years of age and the single marital status was most represented (64.1%). A high proportion of respondents (90.6%) visited VCT service for requiring information (good acceptability)...
2015: Journal of Tropical Medicine
Njiaza Joseph, Ngo Lemba Tom Esther, Nguelefack Télesphore Benoît, Dzeufiet Djomeni Paul Désiré, Aboubakar Oumarou Bibi-Farouck, Dimo Théophile, Kamtchouing Pierre
ETHNOPHARMACOLOGICAL RELEVANCE: Pittosporum mannii Hook. f. (Pittosporaceae) is a plant widely used in traditional medicine in Cameroon for the treatment of many gastrointestinal disorders including diarrhea. To date, no pharmacological study on the antidiarrheal and the antispasmodic properties of this plant has been reported. The aim of the present study was to evaluate in vitro the relaxant activity of the aqueous extract of stem barks of P. mannii (PMAE) on rat duodenum. MATERIALS AND METHODS: Different concentrations of PMAE were tested separately (10-80 µg/mL) or cumulatively (5-80 µg/mL) on spontaneous and spasmogen (carbachol, histamine and KCl)-induced contractions of isolated rat duodenum strips...
August 22, 2015: Journal of Ethnopharmacology
Zbigniew Żuber, Agnieszka Jurecka, Agnieszka Różdżyńska-Świątkowska, Agata Migas-Majoch, Agnieszka Lembas, Beata Kieć-Wilk, Anna Tylki-Szymańska
OBJECTIVES: The primary aim of this study was to assess the ultrasonographic features of hip joints in patients with mucopolysaccharidosis (MPS) type I and II in comparison with healthy population. The secondary aims were to correlate these features with clinical measures and to evaluate the utility of ultrasound in the diagnosis of MPS disease. MATERIALS AND METHODS: Sixteen MPS I (n = 3) and II (n = 13) patients were enrolled in the present study and underwent clinical and radiological evaluation, and bilateral high-resolution ultrasonography (US) of hip joints...
2015: PloS One
Orelien Sylvain Mtopi Bopda, Frida Longo, Thierry Ndzana Bella, Protais Marcellin Ohandja Edzah, Germain Sotoing Taïwe, Danielle Claude Bilanda, Esther Ngo Lemba Tom, Pierre Kamtchouing, Theophile Dimo
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Kalanchoe pinnata (Crassulaceae) are used in Cameroon folk medicine to manage many diseases such as cardiovascular dysfunctions. In this work, we aimed to evaluate the activities of aqueous leaf extract of Kalanchoe pinnata on the blood pressure of normotensive rat (NTR) and salt hypertensive rats (SHR), as well as its antioxidant properties. MATERIALS AND METHODS: Hypertension was induced in rats by oral administration of 18% NaCl for 4 weeks...
April 28, 2014: Journal of Ethnopharmacology
Himla Soodyall
BACKGROUND: Previous historical, anthropological and genetic data provided overwhelming support for the Semitic origins of the Lemba, a Bantu-speaking people in southern Africa. OBJECTIVE: To revisit the question concerning genetic affinities between the Lemba and Jews. METHODS: Y-chromosome variation was examined in two Lemba groups: one from South Africa (SA) and, for the first time, a group from Zimbabwe (Remba), to re-evaluate the previously reported Jewish link...
December 2013: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Esther Ngo Lemba Tom, Corine Girard-Thernier, Hélène Martin, Théophile Dimo, Magalie Alvergnas, Maude Nappey, Alain Berthelot, Céline Demougeot
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Terminalia superba (TS) is widely used as a decoction by Cameroonian folk medicine for the treatment of hypertension. The aim of the present study was to evaluate the effect of a chronic treatment with a TS extract on spontaneously hypertensive rats (SHR) with respect to efficacy, biochemical mechanisms and safety. MATERIALS AND METHODS: Eleven-week-old SHR and normotensive Wistar Kyoto rats (WKY) were daily treated by gavage with a methylene chloride extract of stem bark of Terminalia superba (TMSE, 150mg/kg) or with the vehicle for 5 weeks...
2014: Journal of Ethnopharmacology
Hor Ismail, Bożenna Dembowska-Bagińska, Dorota Broniszczak, Piotr Kaliciński, Przemysław Maruszewski, Przemysław Kluge, Ewa Swięszkowska, Andrzej Kościesza, Agnieszka Lembas, Danuta Perek
BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) represents less than 5% of all malignant hepatic tumors in childhood. It is considered an aggressive neoplasm with an unfavorable prognosis. The aim of this paper is to present a single center experience in the treatment of children with UESL. MATERIALS AND METHODS: Ten children with UESL were treated between 1981 and 2012. Age at diagnosis ranged from 4 months to 17 years (median age, 6 years and 9 months)...
November 2013: Journal of Pediatric Surgery
Bibi-Farouck Aboubakar Oumarou, Linda Martiale Tchuemdem, Paul Désiré Dzeufiet Djomeni, Danielle Claude Bilanda, Esther Ngo Lemba Tom, Martin Thierry Bella Ndzana, Dimo Théophile
ETHNOPHARMACOLOGICAL RELEVANCE: Jateorhiza macrantha is a medicinal plant used in popular medicine to treat several diseases, including cardiovascular disorders. To date, there is no documented report available on the toxicological profile of this medicinal plant. THE AIM OF THE STUDY: The present study was carried out to investigate the mineral content and the safety of the oral administration of the leaf aqueous extract of Jateorhiza macrantha in mice. MATERIALS AND METHODS: The presence of Ca, Mg, K, Na, Cu, Mn, Fe and Zn in the extract was analyzed using Atomic Absorption Spectrophotometer...
August 26, 2013: Journal of Ethnopharmacology
Lemba D Nshisso, Angela Reese, Bizu Gelaye, Sebelewengel Lemma, Yemane Berhane, Michelle A Williams
OBJECTIVE: To determine the prevalence of hypertension and diabetes among members of an Ethiopian occupational cohort; and to examine the proportion of adults who were aware of their conditions. METHODS: A total of 2153 of subjects were included in this cross-sectional study. The World Health Organization STEPwise approach for non-communicable diseases was used to collect socio-demographic data, blood pressure measures and blood samples from participants. Prevalence estimates for hypertension and diabetes were determined separately...
January 2012: Diabetes & Metabolic Syndrome
Hor Ismail, Dorota Broniszczak, Piotr Kaliciński, Bożenna Dembowska-Bagińska, Danuta Perek, Joanna Teisseyre, Przemyslaw Kluge, Andrzej Kościesza, Agnieszka Lembas, Malgorzata Markiewicz
BACKGROUND/PURPOSE: The aim of the study was to analyze changing management and survival of children with hepatoblastoma (HBL) treated in one center. MATERIALS AND METHODS: Over the last 20 years, 51 children with HBL were treated. Surgery was performed in 48 children (94.1%), conventional liver resection in 38 (of those, 2 received a rescue liver transplantation [LTx] for relapse), and total hepatectomy and primary LTx in 10 patients. The remaining 3 patients received only palliative treatment...
July 2012: Journal of Pediatric Surgery
Lubomir Lembas, Józef Jethon
Emergency full thickness abdominal wall defects constitute a challenging problem for surgeons. The aim of reconstruction is prevention of evisceration and hernia formation. Staged surgery is recommended in such cases. The first stage consists of wound healing with skin grafts and creation of "planned hernia". Ultimate reconstruction is delayed until good general health state of the patient. In presented case final skin and subcutaneous tissue reconstruction was achieved with island fasciocutaneous antero-lateral thigh flap...
January 2012: Polski Przeglad Chirurgiczny
Eunju Choi, Dorothy Loo, James W Dennis, Caroline A O'Leary, Michelle M Hill
Alterations in protein glycosylation occur during development and progression of many diseases, hence glycomics and glycoproteomics have emerged as important tools in glycobiomarker discovery. High-throughput glycan profiling can now be achieved with the recent developments in MS-based techniques. To enable identification and rapid monitoring of glycosylation changes in serum proteins, we developed a semi-automated high-throughput glycoprotein biomarker discovery platform termed lectin magnetic bead array-coupled tandem mass spectrometry (LeMBA-MS) which includes (i) effective single-step serum glycoprotein isolation using a panel of 20 individual lectin-coated magnetic beads in microplate format, (ii) on-bead trypsin digestion, and (iii) nanoLC-MS/MS with lectin exclusion list...
December 2011: Electrophoresis
Agnieszka Szlagatys-Sidorkiewicz, Katarzyna Popińska, Ewa Toporowska-Kowalska, Anna Borkowska, Marta Sibilska, Beata Gębora-Kowalska, Stanisław Kłęk, Ewa Hapyn, Jarosław Kierkuś, Urszula Grzybowska-Chlebowczyk, Sabina Więcek, Adam Daukszewicz, Marlena Jakubczyk, Mariola Lembas-Sznabel, Marek Wilczyński, Ilona Zagożdżon, Przemysław Matras, Anna Zmarzly, Janusz Książyk
Published epidemiologic data on the administration rates of enteral/parenteral home nutrition is very limited. The aim of this first nationwide study was to assess the availability of pediatric home enteral nutrition (HEN) services in Poland. The questionnaire was sent to all regional centers providing pediatric HEN services in Poland (n = 14). The analysis included the number of pediatric patients who received HEN in 2010, their demographic characteristics and geographical distribution. Furthermore, the distributions of indications and methods of enteral nutrition administration were analyzed, along with the reasons of withdrawal from the HEN program...
April 2012: European Journal of Pediatrics
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