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https://www.readbyqxmd.com/read/29350487/pediatric-patients-with-cutaneous-melanoma-a-european-study
#1
Ines B Brecht, Angela De Paoli, Gianni Bisogno, Daniel Orbach, Dominik T Schneider, Ulrike Leiter, Sonja Offenmueller, Giovanni Cecchetto, Jan Godzinski, Ewa Bien, Teresa Stachowicz-Stencel, Tal Ben-Ami, Stefano Chiaravalli, Andrea Maurichi, Gian Luca De Salvo, Silvia Sorbara, Christine Bodemer, Claus Garbe, Yves Reguerre, Andrea Ferrari
INTRODUCTION: Cutaneous melanoma is rare in childhood and published studies have mainly been retrospective single-institution series or small case series. Given the absence of clinical protocols dedicated to pediatric melanoma, the treatment approach is generally extrapolated from the ones applied to adults. METHODS: Coordinated by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT), this study collected patients prospectively registered between 2002 and 2012 under national cooperative projects dedicated to rare pediatric tumors in Italy, Poland, Germany, and France...
January 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29343291/trends-in-the-performance-of-quality-indicators-for-diabetes-care-in-the-community-and-in-diabetes-related-health-status-an-israeli-ecological-study
#2
Ronit Calderon-Margalit, Michal Cohen-Dadi, Dana Opas, Dena H Jaffe, Jacob Levine, Arie Ben-Yehuda, Ora Paltiel, Orly Manor
BACKGROUND: Israel is one of the few countries that have a national program for quality assessment of community healthcare. We aimed to evaluate whether improved performance in diabetes care was associated with improved health of diabetic patients on a national level. METHODS: We conducted a nationwide ecological study estimating improvements in diabetes-related quality indicators and health outcomes. We estimated both correlations between composite measures of diabetes-related quality indicators and selected outcomes, and assessed through a joinpoint analysis whether trends in selected outcomes changed 4 years after the inception of the national program...
January 17, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29329166/hematologic-manifestations-of-brucellosis-in-children
#3
Naphtali Justman, Yariv Fruchtman, David Greenberg, Ben-Shimol Shalom
BACKGROUND: Brucellosis is a common zoonosis in the Bedouin population of southern Israel. Limited data exist for the rate and risk factors of hematologic complication of brucellosis in children. We assessed anemia, leukopenia, thrombocytopenia and pancytopenia in childhood brucellosis in southern Israel. METHODS: Our medical center is the sole hospital in southern-Israel. All medical files of brucellosis, 2005-2014, identified through positive blood cultures or International Classification of Diseases 9 revision (ICD9) coding with positive serology, were reviewed retrospectively...
January 11, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29306043/safety-and-effectiveness-of-ledipasvir-and-sofosbuvir-with-or-without-ribavirin-in-treatment-experienced-patients-with-genotype-1-hepatitis-c-virus-infection-and-cirrhosis
#4
Joseph K Lim, Ann Marie Liapakis, Mitchell L Shiffman, Anna S Lok, Stefan Zeuzem, Norah A Terrault, James S Park, Charles S Landis, Mohamed Hassan, Joel Gallant, Alexander Kuo, Paul J Pockros, Monika Vainorius, Lucy Akushevich, Larry Michael, Michael W Fried, David R Nelson, Ziv Ben-Ari
BACKGROUND & AIMS: We aimed to evaluate the safety and effectiveness of 12 or 24 weeks treatment with ledipasvir and sofosbuvir, with or without ribavirin, in treatment-experienced patients with hepatitis C virus (HCV) genotype 1 infection and cirrhosis in routine clinical practice. Patients were followed in a multi-center, prospective, observational cohort study (HCV-TARGET). METHODS: We collected data from 667 treatment-experienced adults with chronic genotype 1 HCV infection who began treatment with ledipasvir and sofosbuvir, with or without ribavirin, from 2011 through September 15, 2016, according to the regional standards of care, at academic (n=39) and community (n=18) centers in the United States, Canada, Germany, and Israel...
January 3, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29294921/domestic-violence-in-arab-society-a-comparison-of-arab-and-jewish-women-in-shelters-in-israel
#5
Anat Ben-Porat, Drorit Levy, Ola Kattoura, Rachel Dekel, Haya Itzhaky
The aim of the current study was to address a gap in the literature by determining prevalence, specific types of violence, and risk factors of intimate partner violence (IPV) among Israeli born Arab women compared with Israeli born Jewish women. The following measures were compared: demographic and socioeconomic measures; measures relating to the characteristics of the violence, that is, the three types of violence (physical, emotional, and verbally threatening), sense of danger, and history of violence in childhood; family support levels; and perpetrator characteristics...
September 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294747/patterns-of-service-utilization-among-women-who-are-victims-of-domestic-violence-the-contribution-of-cultural-background-characteristics-of-violence-and-psychological-distress
#6
Anat Ben-Porat
The study examined patterns of utilization of various services among female victims of domestic violence in Israel. The study looked at how cultural background, characteristics of violence, attempts at separation from partner, and women's emotional distress contributed to patterns of service utilization. The sample of participants included 499 women who arrived at 12 shelters in Israel. Of those participants, 142 were Jewish, 156 were Arab, 125 had been born in the former Soviet Union (FSU), and 76 had been born in Ethiopia...
May 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29284761/refugees-in-conflict-creating-a-bridge-between-traditional-and-conventional-health-belief-models
#7
Eran Ben-Arye, Massimo Bonucci, Michel Daher, Rejin Kebudi, Bashar Saad, Thomas Breitkreuz, Maryam Rassouli, Elio Rossi, Nahla Gafer, Omar Nimri, Mohamed Hablas, Gunver Sophia Kienle, Noah Samuels, Michael Silbermann
The recent wave of migration from Middle Eastern countries to Europe presents significant challenges to the European health profession. These include the inevitable communication gap created by differences in health care beliefs between European oncologists, health care practitioners, and refugee patients. This article presents the conclusions of a workshop attended by a group of clinicians and researchers affiliated with the Middle East Cancer Consortium, as well as four European-based health-related organizations...
December 28, 2017: Oncologist
https://www.readbyqxmd.com/read/29241475/israeli-national-policy-for-carbapenem-resistant-enterobacteriaceae-screening-carrier-isolation-and-discontinuation-of-isolation
#8
Ester Solter, Amos Adler, Bina Rubinovitch, Elizabeth Temkin, David Schwartz, Debby Ben-David, Samira Masarwa, Yehuda Carmeli, Mitchell J Schwaber
Since 2006, Israel has been confronting an outbreak of carbapenem-resistant Enterobacteriaceae (CRE), and in 2007 Israel implemented a national strategy to contain spread. The intervention was initially directed toward acute-care hospitals and later expanded to include an established reservoir of carriage in long-term-care hospitals. It included regular reporting of CRE cases to a central registry and daily oversight of management of the outbreak at the institutional level. Microbiological methodologies were standardized in clinical laboratories nationwide...
December 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29223444/association-of-vedolizumab-level-anti-drug-antibodies-and-%C3%AE-4%C3%AE-7-occupancy-with-response-in-patients-with-inflammatory-bowel-diseases
#9
Bella Ungar, Uri Kopylov, Miri Yavzori, Ella Fudim, Orit Picard, Adi Lahat, Daniel Coscas, Matti Waterman, Ola Haj-Natour, Noam Orbach-Zingboim, Ren Mao, Minhu Chen, Yehuda Chowers, Rami Eliakim, Shomron Ben-Horin
BACKGROUND & AIMS: There are few data available on the real-life pharmacokinetic and pharmacodynamics features of vedolizumab, a monoclonal antibody against integrin α4β7. We performed a prospective study of patients with inflammatory bowel diseases (IBD) treated with vedolizumab to determine serum drug concentrations, formation of anti-vedolizumab antibodies (AVAs), and integrin α4β7 saturation. METHODS: We performed a prospective study of 106 patients with IBD (67 with Crohn's disease and 39 with ulcerative colitis) treated with vedolizumab from September 2014 through March 2017 at 2 tertiary medical centers in Israel...
December 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29179829/the-impact-of-mental-health-reform-on-mental-illness-stigmas-in-israel
#10
Merav Ben Natan, Tal Drori, Ohad Hochman
This study examined public perception of stigmas relating to mental illness six months after a reform, which integrated mental health care into primary care in Israel. The results reveal that the public feels uncomfortable seeking referral to mental health services through the public health system, with Arab Israelis and men expressing lower levels of comfort than did Jewish Israelis. The current reform has not solved the issue of public stigma regarding mental health care. The study suggests that the current reforms must be accompanied over time with appropriate public education regarding mental illness...
December 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29143272/preliminary-results-of-immune-modulating-antibody-mdv9300-pidilizumab-treatment-in-children-with-diffuse-intrinsic-pontine-glioma
#11
Iris Fried, Alex Lossos, Tal Ben Ami, Rina Dvir, Helen Toledano, Myriam Weil Ben Arush, Sergei Postovski, Abed Abu Kuidar, Michal Yalon, Michael Weintraub, Mony Benifla
Diffuse intrinsic pontine glioma (DIPG) is an incurable disease with a median overall survival of 10 months. Immune modulating antibodies have recently emerged as a highly promising treatment modality in multiple cancer types. We present results from the first study to evaluate the immune modulating antibody MDV9300 (pidilizumab) in pediatric patients with DIPG. All patients aged 3 years and older, diagnosed with DIPG between February 2014 and June 2015 in Israel, were offered to participate in the study...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29132368/frequency-of-canine-nt230-del4-mdr1-mutation-in-prone-pure-breeds-their-crosses-and-mongrels-in-israel-insights-from-a-worldwide-comparative-perspective
#12
Yaron Dekel, Yossy Machluf, Aviad Stoler, Arava Aderet, Daniel Baumel, Efrat Kellerman, Yoram Plotsky, Oshrat Noked Partouche, Gal Elhalal, Izhar Ben-Shlomo, Dani Bercovich
BACKGROUND: Sensitivity to macrocyclic lactones, which are commonly used in veterinary clinics, was first found in Rough Collies, and was attributed in 2001 to a 4 bp deletion in the MDR1 gene. The list of affected breeds currently includes 13 breeds. Researchers from different countries and continents examined the allelic frequencies of the nt230(del4) MDR1 mutation, emphasizing the clinical importance of this test not only to mutation-prone dogs, but also to their crosses and mongrels, since treatment of a deletion carrier with these compounds may lead to its death...
November 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29080709/internet-based-monitoring-in-the-severe-asthma-research-program-identifies-a-subgroup-of-patients-with-labile-asthma-control
#13
Kelly Wong-McGrath, Loren C Denlinger, Eugene R Bleecker, Mario Castro, Ben Gaston, Elliot Israel, Nizar N Jarjour, David T Mauger, Stephen Peters, Brenda R Phillips, Sally E Wenzel, John V Fahy, Michael C Peters
BACKGROUND: We designed an Internet-Based Monitoring Systems (IBS) survey to facilitate monitoring of asthma symptoms and asthma exacerbations in the Severe Asthma Research Program (SARP). Our objective was to evaluate compliance with the IBS survey tool and to explore how data from an IBS tool can inform understanding of asthma phenotypes. METHODS: We invited adult subjects in the SARP III cohort (N = 528) to complete a monthly IBS asthma control survey. We compared the characteristics of subjects who did and those who did not participate in the IBS survey tool...
October 26, 2017: Chest
https://www.readbyqxmd.com/read/29032294/one-year-double-blind-study-of-high-vs-low-frequency-subcallosal-cingulate-stimulation-for-depression
#14
Renana Eitan, Denys Fontaine, Michel Benoît, Caroline Giordana, Nelly Darmon, Zvi Israel, Eduard Linesky, David Arkadir, Shiri Ben-Naim, Moshe Iserlles, Hagai Bergman, Natasha Hulse, Mohamed Abdelghani, Peter McGuffin, Anne Farmer, Peichel DeLea, Keyoumars Ashkan, Bernard Lerer
Subcallosal Brodmann's Area 25 (Cg25) Deep Brain Stimulation (DBS) is a new promising therapy for treatment resistant major depressive disorder (TR-MDD). While different DBS stimulating parameters may have an impact on the efficacy and safety of the therapy, there is no data to support a protocol for optimal stimulation parameters for depression. Here we present a prospective multi-center double-blind randomized crossed-over 13-month study that evaluated the effects of High (130 Hz) vs Low (20 Hz) frequency Cg25 stimulation for nine patients with TR-MDD...
October 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29031046/contributors-to-young-drivers-driving-styles-a-comparison-between-israel-and-queensland
#15
Vera Skvirsky, Orit Taubman Ben-Ari, Timothy J Greenbury, Carlo G Prato
Among the numerous factors that contribute to young novice drivers' driving styles, personality characteristics, sociodemographic variables, family atmosphere, and friends' norms are known to have an important impact. However, cross-cultural comparisons are relatively rare in the safety literature concerning young drivers. This study aimed at comparing young drivers from Israel and Queensland (Australia) and examining the contribution of personality, sociodemographic, family and friends' aspects to their driving styles (reckless and careless; hostile and angry; anxious; patient and careful)...
October 10, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29030730/introduction-eric-davidson-and-the-molecular-biology-of-evolution-and-development
#16
EDITORIAL
Michel Morange, Ute Deichmann
Between November 30th and December 2nd, 2015, the Jacques Loeb Centre for the History and Philosophy of the Life Sciences at Ben-Gurion University of the Negev in Beer Sheva (Israel) held its Eighth International Workshop under the title "From Genome to Gene: Causality, Synthesis and Evolution". Eric Davidson, the founder of the concept of developmental Gene Regulatory Networks, had regularly attended the previous meetings, and his participation in this one was expected, but he suddenly passed away 3 months before...
October 13, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29024067/evaluation-of-multiplex-real-time-pcr-for-identifying-dermatophytes-in-clinical-samples-a-multicentre-study
#17
Shany Sherman, Maya Goshen, Orit Treigerman, Keren Ben-Zion, Marie-Jeanne Carp, Noam Maisler, Inbal Binsky Ehrenreich, Aviva Kimchi, Sara Lifshitz, Gill Smollan, Batya Davidovici, Michael David, Emmilia Hodak, Rina Segal
The gold-standard method for dermatophyte identification involves direct microscopy and culture, which have inherent shortcomings. Only few molecular methods have been standardised for routine clinical work. This study aimed to develop and test a platform for identifying the most common dermatophytes in Israel using multiplex real-time polymerase chain reaction (RT-PCR). Specific primers were designed for the multiplex system (LightCycler 480) according to known cultures and validated by reference isolates...
February 2018: Mycoses
https://www.readbyqxmd.com/read/28992365/familial-mediterranean-fever-and-incidence-of-cancer-an-analysis-of-8534-patients-with-258-803-person-years
#18
Ronen Brenner, Ilan Ben-Zvi, Yael Shinar, Irena Liphshitz, Barbara Silverman, Nir Peled, Carmit Levy, Eldad Ben-Chitrit, Avi Livneh, Shaye Kivity
OBJECTIVE: Familial Mediterranean fever (FMF) is an autoinflammatory disease manifested with recurrent serosal inflammation. The association between FMF and malignancy has not been described. The aim of this study was to estimate cancer risk in a large single-institution cohort of FMF patients. METHODS: The study cohort consisted of 8,534 FMF patients registered in the Israel National FMF Center at Tel Hashomer, Israel. We linked the study cohort to the database of the Israel National Cancer Registry using the national identity number...
October 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28968074/structural-characterization-of-am-iii-and-pu-iii-dota-complexes
#19
Matthieu Audras, Laurence Berthon, Claude Berthon, Dominique Guillaumont, Thomas Dumas, Marie-Claire Illy, Nicolas Martin, Israel Zilbermann, Yulia Moiseev, Yeshayahu Ben-Eliyahu, Armand Bettelheim, Sebastiano Cammelli, Christoph Hennig, Philippe Moisy
The complexation of 1,4,7,10-tetrazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) ligand with two trivalent actinides (Am(3+) and Pu(3+)) was investigated by UV-visible spectrophotometry, NMR spectroscopy, and extended X-ray absorption fine structure in conjunction with computational methods. The complexation process of these two cations is similar to what has been previously observed with lanthanides(III) of similar ionic radius. The complexation takes place in different steps and ends with the formation of a (1:1) complex [(An(III)DOTA)(H2O)](-), where the cation is bonded to the nitrogen atoms of the ring, the four carboxylate arms, and a water molecule to complete the coordination sphere...
October 2, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28966825/acute-vertex-epidural-hematoma
#20
David Ben-Israel, Albert M Isaacs, William Morrish, Naomi C Gallagher
No abstract text is available yet for this article.
2017: Surgical Neurology International
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