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https://www.readbyqxmd.com/read/28188202/progressive-prediction-of-hospitalisation-in-the-emergency-department-uncovering-hidden-patterns-to-improve-patient-flow
#1
Yuval Barak-Corren, Shlomo Hanan Israelit, Ben Y Reis
INTRODUCTION: One of the factors contributing to ED crowding is the lengthy delay in transferring an admitted patient from the ED to an inpatient department (ie, boarding time). An earlier start of the admission process using an automatic hospitalisation prediction model could potentially shorten these delays and reduce crowding. METHODS: Clinical, operational and demographic data were retrospectively collected on 80 880 visits to the ED of Rambam Health Care Campus in Haifa, Israel, from January 2011 to January 2012...
February 10, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28178003/efficacy-and-safety-of-vedolizumab-for-induction-of-remission-in-inflammatory-bowel-disease-the-israeli-real-world-experience
#2
Uri Kopylov, Yulia Ron, Irit Avni-Biron, Benjamin Koslowsky, Matti Waterman, Saleh Daher, Bella Ungar, Henit Yanai, Nitsan Maharshak, Ofer Ben-Bassat, Lev Lichtenstein, Ariella Bar-Gil Shitrit, Eran Israeli, Doron Schwartz, Eran Zittan, Rami Eliakim, Yehuda Chowers, Shomron Ben-Horin, Iris Dotan
BACKGROUND: Vedolizumab (VDZ) is an anti-integrin monoclonal antibody effective in ulcerative colitis (UC) and Crohn's disease (CD). The aim of this study was to examine the "real world" efficacy and safety of VDZ in a large national patient cohort. METHODS: Patients with inflammatory bowel disease treated with VDZ were prospectively followed for 14 weeks. Patients who completed the induction protocol (week 0/2/6/14) or discontinued the treatment before week 14 for adverse events (AEs) or primary nonresponse were included...
February 7, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28172738/p721-a-switch-in-the-prevalence-ratio-of-crohn-s-disease-vs-ulcerative-colitis-in-israel-between-2003-and-2015-a-report-from-the-epi-iirn-group
#3
M Friedman, S Odes, R Balicer, M Hoshen, D Cohen, J Rosenblum, N Zigman, I Goren, N Lederman, E Matz, D Dushnitzky, N Borovsky, M Gavish, G Focht, M Avitzour, R Axelrod, Y Chowers, R Eliakim, S Ben-Horin, I Dotan, E Israeli, Z Levy, E Benchimol, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28147280/ebi2-is-highly-expressed-in-multiple-sclerosis-lesions-and-promotes-early-cns-migration-of-encephalitogenic-cd4%C3%A2-t-cells
#4
Florian Wanke, Sonja Moos, Andrew L Croxford, André P Heinen, Stephanie Gräf, Bettina Kalt, Denise Tischner, Juan Zhang, Isabelle Christen, Julia Bruttger, Nir Yogev, Yilang Tang, Morad Zayoud, Nicole Israel, Khalad Karram, Sonja Reißig, Sonja M Lacher, Christian Reichhold, Ilgiz A Mufazalov, Avraham Ben-Nun, Tanja Kuhlmann, Nina Wettschureck, Andreas W Sailer, Klaus Rajewsky, Stefano Casola, Ari Waisman, Florian C Kurschus
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate cholesterol to 7α,25-OHC. During EAE, we found increased expression of CH25H by microglia and CYP7B1 by CNS-infiltrating immune cells elevating the ligand concentration in the CNS. Two critical pro-inflammatory cytokines, interleukin-23 (IL-23) and interleukin-1 beta (IL-1β), maintained expression of EBI2 in differentiating Th17 cells...
January 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/28112461/intention-to-receive-the-seasonal-influenza-vaccine-among-nurses-working-in-a-long-term-care-facility
#5
Irit Shahar, Gad Mendelson, Merav Ben Natan
The factors affecting influenza vaccine uptake among nurses might vary between different medical facilities. The purpose of the present study was to explore factors that affect the intention of nurses at a long-term care facility to receive the influenza vaccine and whether the health belief model predicts this intention. In this cross-sectional quantitative correlational study, a convenience sample of 150 nurses employed at a large long-term care facility in central Israel completed a questionnaire based on the health belief model...
January 23, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28098529/multidrug-resistant-candida-haemulonii-and-c-auris-tel-aviv-israel
#6
Ronen Ben-Ami, Judith Berman, Ana Novikov, Edna Bash, Yael Shachor-Meyouhas, Shiri Zakin, Yasmin Maor, Jalal Tarabia, Vered Schechner, Amos Adler, Talya Finn
Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C...
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28096281/de-freezing-frozen-patient-management
#7
Ayala Kobo-Greenhut, Amin Shnifi, Eran Tal-Or, Racheli Magnezi, Amos Notea, Meir Ruach, Erez Onn, Ayala Cohen, Etti Doveh, Izhar Ben Shlomo
OBJECTIVE: To compare the effectiveness of two methods in encouraging the consideration of a leap from one patient management routine to another: (i) real-time review of the facts by an external medical team (ii) implementation of the 're-thinking-protocol' ('de-Freezing') by both treating and external medical teams. DESIGN: Students accompanied doctors, nurses and patients as non-interrupting observers. When an obvious gap between the expected and actual findings occurred, it was discussed four times: by two teams (treating team, external medical team) in two discussion modes (real-time review, de-Freezing-questionnaire)...
January 16, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28062907/prediction-of-fetal-loss-by-first-trimester-crown-rump-length-in-ivf-pregnancies
#8
Rinat Gabbay-Benziv, Amir Dolev, Ron Bardin, Israel Meizner, Benjamin Fisch, Avi Ben-Haroush
OBJECTIVE: To evaluate the association between small crown-rump length (CRL) and fetal loss ≤22 weeks in IVF pregnancies. METHODS: A retrospective analysis of prospectively collected data at a university-affiliated medical center. All singleton IVF pregnancies within a 5-year period, with a live embryo on first-trimester ultrasound and verified pregnancy outcome were included. Rates of fetal loss ≤22 weeks were compared between pregnancies with a CRL ≤tenth percentile and above the tenth percentile of our population...
January 7, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28060602/patient-violence-toward-psychiatric-health-care-workers-in-israel-as-viewed-through-incident-reports
#9
Tal Drori, Hava Guetta, Merav Ben Natan, Yaakov Polakevich
BACKGROUND: Rates of violence perpetrated by patients toward health care workers are known to be higher in psychiatry than in other fields. Objective standardized reports of violent incidents may clarify this phenomenon. OBJECTIVE: The purpose of this study was to assess the characteristics of patient violence, as evident from objective reports. STUDY DESIGN: In this retrospective chart review study, conducted at a large mental health hospital in Israel between 2013 and 2015, reports of violent incidents perpetrated by people diagnosed with mental health problems against health care workers of the hospital were reviewed...
January 1, 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28051970/the-effect-of-aging-on-the-ventilatory-response-to-wearing-a-chemical-biological-radiological-and-nuclear-hood-respirator-at-rest-and-during-mild-exercise
#10
Dror Ofir, Yoav Yanir, Mirit Eynan, Ben Aviner, Adi Biram, Michael Mullokandov, Ronen Bar, Yehuda Arieli
BACKGROUND: Structural changes in the human body resulting from aging may affect the response to altered levels of O2 and CO2. An abnormal ventilatory response to a buildup of CO2 in the inspired air due to rebreathing may result in adverse effects, which will impair the individual's ability to function under stress. The purpose of this study was to evaluate the effect of age on the respiratory response to wearing an escape hood at rest and during mild exercise. METHODS: Subjects were seven healthy, young adult males (20-30 years) and seven healthy, middle-aged males (45-65 years)...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28045486/mimicking-neuroligin-2-functions-in-%C3%AE-cells-by-functionalized-nanoparticles-as-a-novel-approach-for-antidiabetic-therapy
#11
Anna Munder, Liron L Israel, Shirin Kahremany, Rina Ben-Shabat-Binyamini, Charles Zhang, Michal Kolitz-Domb, Olga Viskind, Anna Levine, Hanoch Senderowitz, Steven Chessler, Jean-Paul Lellouche, Arie Gruzman
Both pancreatic β-cell membranes and presynaptic active zones of neurons include in their structures similar protein complexes, which are responsible for mediating the secretion of bioactive molecules. In addition, these membrane-anchored proteins regulate interactions between neurons and guide the formation and maturation of synapses. These proteins include the neuroligins (e.g., NL-2) and their binding partners, the neurexins. The insulin secretion and maturation of β-cells is known to depend on their 3-dimensional (3D) arrangement...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28040286/balloon-dilatation-and-outcome-among-patients-undergoing-trans-femoral-aortic-valve-replacement
#12
Noam Fink, Amit Segev, Ran Kornowski, Ariel Finkelstein, Abid Assali, Zach Rozenbaum, Hana Vaknin-Assa, Amir Halkin, Paul Fefer, Jeremy Ben-Shoshan, Ehud Regev, Maayan Konigstein, Katia Orvin, Victor Guetta, Israel M Barbash
BACKGROUND: Balloon pre-dilatation before transcatheter aortic valve replacement (TAVR) is performed at the discretion of the treating physician. Clinical data assessing the implications of this step on procedural outcomes are limited. METHODS: We conducted a retrospective analysis of 1164 consecutive TAVR patients in the Israeli multicenter TAVR registry (Sheba, Rabin, and Tel Aviv Medical Centers) between the years 2008 and 2014. Patients were divided to those who underwent balloon pre-dilation (n=1026) versus those who did not (n=138)...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27993711/late-onset-uretero-vesical-junction-obstruction-following-endoscopic-injection-of-bulking-material-for-the-treatment-of-vesico-ureteral-reflux
#13
David Ben-Meir, Zaher Bahouth, Sarel Halachmi
OBJECTIVE: To characterize patients who develop late obstruction after subureteral injection of bulking agent for the treatment of pediatric vesicoureteral reflux (VUR). METHODS: We retrospectively evaluated the medical records of all patients who underwent endoscopic injection for the correction of VUR during 2008-2015 in 2 centers in Israel: Bnai-Zion Medical Center, Haifa, and Schneider Children's Medical Center, Petah Tikva. Nine patients who developed late-onset obstruction were included in the study, and their data were reviewed and analyzed...
December 16, 2016: Urology
https://www.readbyqxmd.com/read/27992417/mutations-in-the-histone-methyltransferase-gene-kmt2b-cause-complex-early-onset-dystonia
#14
Esther Meyer, Keren J Carss, Julia Rankin, John M E Nichols, Detelina Grozeva, Agnel P Joseph, Niccolo E Mencacci, Apostolos Papandreou, Joanne Ng, Serena Barral, Adeline Ngoh, Hilla Ben-Pazi, Michel A Willemsen, David Arkadir, Angela Barnicoat, Hagai Bergman, Sanjay Bhate, Amber Boys, Niklas Darin, Nicola Foulds, Nicholas Gutowski, Alison Hills, Henry Houlden, Jane A Hurst, Zvi Israel, Margaret Kaminska, Patricia Limousin, Daniel Lumsden, Shane McKee, Shibalik Misra, Shekeeb S Mohammed, Vasiliki Nakou, Joost Nicolai, Magnus Nilsson, Hardev Pall, Kathryn J Peall, Gregory B Peters, Prab Prabhakar, Miriam S Reuter, Patrick Rump, Reeval Segel, Margje Sinnema, Martin Smith, Peter Turnpenny, Susan M White, Dagmar Wieczorek, Sarah Wiethoff, Brian T Wilson, Gidon Winter, Christopher Wragg, Simon Pope, Simon J H Heales, Deborah Morrogh, Alan Pittman, Lucinda J Carr, Belen Perez-Dueñas, Jean-Pierre Lin, Andre Reis, William A Gahl, Camilo Toro, Kailash P Bhatia, Nicholas W Wood, Erik-Jan Kamsteeg, Wui K Chong, Paul Gissen, Maya Topf, Russell C Dale, Jonathan R Chubb, F Lucy Raymond, Manju A Kurian
Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to be critical in the regulation of gene expression, genomic stability, cell cycle and nuclear architecture. Despite MLL proteins being postulated as essential for normal development, little is known about the specific functions of the different MLL lysine methyltransferases. Here we report heterozygous variants in the gene KMT2B (also known as MLL4) in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated with a typical facial appearance and characteristic brain magnetic resonance imaging findings...
December 19, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27964727/genetic-variation-of-naturally-growing-olive-trees-in-israel-from-abandoned-groves-to-feral-and-wild
#15
Oz Barazani, Alexandra Keren-Keiserman, Erik Westberg, Nir Hanin, Arnon Dag, Giora Ben-Ari, Ori Fragman-Sapir, Yizhar Tugendhaft, Zohar Kerem, Joachim W Kadereit
BACKGROUND: Naturally growing populations of olive trees are found in the Mediterranean garrigue and maquis in Israel. Here, we used the Simple Sequence Repeat (SSR) genetic marker technique to investigate whether these represent wild var. sylvestris. Leaf samples were collected from a total of 205 trees at six sites of naturally growing olive populations in Israel. The genetic analysis included a multi-locus lineage (MLL) analysis, Rousset's genetic distances, Fst values, private alleles, other diversity values and a Structure analysis...
December 13, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27939127/cocontribution-of-rotavirus-and-pneumococcal-conjugate-vaccines-to-the-reduction-of-pediatric-hospital-visits-in-young-children
#16
Shalom Ben-Shimol, Noga Givon-Lavi, David Greenberg, Ron Dagan
OBJECTIVE: To assess rotavirus vaccine and pneumococcal conjugate vaccines (PCVs) cumulative impact on the pediatric emergency department visits and hospitalization rates in children <2 years of age in southern Israel between April 2006 and March 2014. STUDY DESIGN: This prospective, population-based observational study calculated the rates of rotavirus gastroenteritis (RVGE), non-RVGE, community-acquired alveolar pneumonia (CAAP), nonalveolar lower respiratory tract infection, and all-cause hospital visits...
December 8, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27879969/factors-associated-with-choice-of-approach-for-group-b-streptococcus-screening
#17
H Sefty, A Klivitsky, M Bromberg, R Dichtiar, M Ben Ami, T Shohat, A Glatman-Freedman
BACKGROUND: The crude rate of early-onset Group B streptococcus disease (EOGBS) in Israel has been consistently under 0.5 for 1000 live births for the past 8 years. The Israeli Ministry of Health has adapted the risk factor based approach for preventing EOGBS and universal bacteriological screening for GBS is not recommended. In spite of this policy, there are indications that many pregnant women in Israel undergo bacteriological screening for GBS. The objective of this study is to assess the rate and characteristics of pregnant women who undergo screening for group B streptococcus (GBS) colonization in Israel...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27876594/successful-control-of-a-large-outbreak-of-hiv-infection-associated-with-injection-of-cathinone-derivatives-in-tel-aviv-israel
#18
Eugene Katchman, Ronen Ben-Ami, Michal Savyon, Daniel Chemtob, Boaz Avidor, Asaf Wasserman, Irena Zeldis, Shirley Girshengorn, Ziva Amitai, Rivka Sheffer, Dan Turner
OBJECTIVES: Outbreaks of HIV infection have been linked to injectable drug abuse, but specific triggers often remain obscure. We report on an outbreak of primary HIV infection among people who inject drugs (PWID) in Tel Aviv, associated with a local shift in drug-use practices. METHODS: A cluster of primary HIV infection cases in PWID was detected in May 2012. Retrospective and prospective multi-hospital case finding was initiated. PWID were interviewed and risk factors for primary HIV infection were identified...
November 19, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27864577/diagnosing-necrotic-meningioma-a-distinctive-imaging-pattern-in-diffusion-mri-and-mr-spectroscopy
#19
Gal Ben-Arie, Yonatan Serlin, Sebastian Ivens, Mony Benifla, Emanuela Cagnano, Israel Melamed, Vladimir Merkin, Ilan Shelef
The differential diagnosis of necrotic meningiomas includes brain abscess and malignant neoplasms. We report and discuss hereby the work-up of two patients diagnosed with necrotic meningioma using diffusion-weighted imaging, magnetic resonance spectroscopy, resective surgery, and histopathology. The purpose of the present article is to add to the scant literature on the use of advanced imaging modalities in the routine investigation of brain lesions and their utility in arriving at the final diagnosis.
November 18, 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27844150/c-shaped-canals-prevalence-and-root-canal-configuration-by-cone-beam-computed-tomography-evaluation-in-first-and-second-mandibular-molars-a-cross-sectional-study
#20
Avi Shemesh, Avi Levin, Vered Katzenell, Joe Ben Itzhak, Oleg Levinson, Zini Avraham, Michael Solomonov
OBJECTIVES: C-shaped root canal configuration is an unusual root canal morphology and one of the most often anatomical variations in root canal systems of second mandibular molars. The purpose of this study was to assess the prevalence, symmetry and configuration of C-shaped canals in first and second mandibular molars in an Israeli population using cone beam computed tomography (CBCT). MATERIALS AND METHODS: One thousand twenty Israel patients' CBCT scans were screened and evaluated...
November 14, 2016: Clinical Oral Investigations
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