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https://www.readbyqxmd.com/read/28736139/long-term-response-after-stopping-tenofovir-disoproxil-fumarate-in-non-cirrhotic-hbeag-negative-patients-finite-study
#1
Thomas Berg, Karl-Georg Simon, Stefan Mauss, Eckart Schott, Renate Heyne, Dietmar M Klass, Christoph Eisenbach, Tania Mara Welzel, Reinhart Zachoval, Gisela Felten, Julian Schulze-Zur-Wiesch, Markus Cornberg, Marjoleine L Op den Brouw, Belinda Jump, Hans Reiser, Lothar Gallo, Tobias Warger, Jörg Petersen
BACKGROUND & AIMS: There is currently no virological cure for chronic hepatitis B but successful nucleos(t)ide analogue (NA) therapy can suppress hepatitis B virus (HBV) DNA replication and, in some cases, result in HBsAg loss. Stopping NA therapy often leads to viral relapse and therefore life-long therapy is usually required. This study investigated the potential to discontinue tenofovir disoproxil fumarate (TDF) therapy in HBeAg-negative patients. METHODS: Non-cirrhotic HBeAg-negative patients who had received TDF for ≥4 years, with suppressed HBV DNA for ≥3...
July 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28733882/prediction-of-the-lowest-charge-transfer-excited-state-energy-at-the-donor-acceptor-interface-in-a-condensed-phase-using-ground-state-dft-calculations-with-generalized-kohn-sham-functionals
#2
Shaohui Zheng, Mengyue Xiao, Yongping Tian, Xue Chen
Knowledge of the charge (electron) transfer process at the donor-acceptor interface is required to understand the working mechanisms of different organic photovoltaic materials. Investigating the lowest charge-transfer state in organic donor-acceptor solar cells is important as it allows the destruction/formation of excitons and polarons to be studied, and is directly related to the open circuit voltage. By performing low-cost and feasible calculations of ground-state electronic structures using the Mulliken rule as well as the optimally tuned range-separated hybrid (OTRSH) density functional and a regular long-range corrected functional, the lowest charge-transfer (CT) state energies of a series of dimers containing functionalized anthracene (the donor) and tetracyanoethylene (the acceptor) were obtained...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28728471/implementing-technical-refinement-in-high-level-athletics-exploring-the-knowledge-schemas-of-coaches
#3
Philip E Kearney, Howie J Carson, Dave Collins
This paper explores the approaches adopted by high-level field athletics coaches when attempting to refine an athlete's already well-established technique (long and triple jump and javelin throwing). Six coaches, who had all coached multiple athletes to multiple major championships, took part in semi-structured interviews focused upon a recent example of technique refinement. Data were analysed using a thematic content analysis. The coaching tools reported were generally consistent with those advised by the existing literature, focusing on attaining "buy-in", utilising part-practice, restoring movement automaticity and securing performance under pressure...
July 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28723417/long-term-morphine-delivery-via-slow-release-morphine-pellets-or-osmotic-pumps-plasma-concentration-analgesia-and-naloxone-precipitated-withdrawal
#4
Virginia D McLane, Ivy Bergquist, James Cormier, Deborah J Barlow, Karen L Houseknecht, Edward J Bilsky, Ling Cao
AIMS: Slow-release morphine sulfate pellets and osmotic pumps are common routes of chronic morphine delivery in mouse models, but direct comparisons of these drug delivery systems are lacking. In this study, we assessed the efficacy of slow-release pellets versus osmotic pumps in delivering morphine to adult mice. MAIN METHODS: Male C57BL/6NCr mice (8weeksold) were implanted subcutaneously with slow-release pellets (25mg morphine sulfate) or osmotic pumps (64mg/mL, 1...
July 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/28719491/greater-effect-of-east-vs-west-travel-on-jet-lag-sleep-and-team-sport-performance
#5
Peter M Fowler, Wade Knez, Stephen Crowcroft, Amy E Mendham, Joanna Miller, Charlie Sargent, Shona Halson, Rob Duffield
PURPOSE: Determine the recovery timeline of sleep, subjective jet-lag and fatigue, and team-sport physical performance following east and west long-haul travel. METHODS: Ten, physically-trained males underwent testing at 09:00 (AM) and 17:00 (PM) local time on four consecutive days two weeks prior to outbound travel (BASE), and the first four days following 21 h of outbound (WEST) and return (EAST) air travel across eight time-zones between Australia and Qatar. Data collection included performance (countermovement jump [CMJ], 20-m sprint and Yo-Yo Intermittent Recovery level 1 [YYIR1] test) and perceptual (jet-lag, motivation, perceived exertion and physical feeling) measures...
July 17, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28715199/jumping-hurdles-peptides-able-to-overcome-biological-barriers
#6
Macarena Sánchez-Navarro, Meritxell Teixidó, Ernest Giralt
The cell membrane, the gastrointestinal tract, and the blood-brain barrier (BBB) are good examples of biological barriers that define and protect cells and organs. They impose different levels of restriction, but they also share common features. For instance, they all display a high lipophilic character. For this reason, hydrophilic compounds, like peptides, proteins, or nucleic acids have long been considered as unable to bypass them. However, the discovery of cell-penetrating peptides (CPPs) opened a vast field of research...
July 17, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28712313/compulsory-military-service-as-a-measure-of-later-physical-and-cognitive-performance-in-male-survivors-of-childhood-cancer
#7
Ritva Ahomäki, Arja Harila-Saari, Kai Parkkola, Jaakko Matomäki, Päivi M Lähteenmäki
BACKGROUND: Compromised physical fitness and cognitive difficulties have been reported as late effects of cancer treatment during childhood. To assess this issue, the military rankings of cancer survivors in medical checkups at call-up, and conscripts' physical and cognitive performance during the first weeks of compulsory military education were compared to those of matched population controls without a history of cancer. MATERIAL AND METHODS: A total of 1680 male patients born between 1960 and 1992 with a malignancy diagnosed before the age of 16 who were alive at the call-up age (18 years) were identified using the Finnish Cancer Registry, and five age, sex and place of residence matched controls for each patient using the Population Register Centre...
July 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28708946/sports-participation-functional-outcome-and-complications-after-ankle-arthrodesis-midterm-follow-up
#8
Yvonne R A Kerkhoff, Noël L W Keijsers, Jan Willem K Louwerens
BACKGROUND: Ankle arthrodesis provides satisfactory functional outcome based on basic daily activities, but information regarding more demanding tasks is limited. Also, studies reporting longer term survival and complication rates are sparse and concern small study populations. This study reports functional outcome with more focus on demanding tasks and sports and reports the mid- to long-term union and complication rates in a large study population. METHODS: Between 2005 and 2010, an ankle arthrodesis was performed on 185 ankles...
July 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28707506/perception-action-coupling-in-complex-game-play-exploring-the-quiet-eye-in-contested-basketball-jump-shots
#9
André Klostermann, Derek Panchuk, Damian Farrow
The duration of the final fixation before movement initiation - a gaze strategy labelled quiet eye - has been found to explain differences in motor expertise and performance in precision tasks. To date, research only addressed this phenomenon in situations without adversarial constraints. In the present study, we compared the quiet-eye behaviour of intermediately-skilled and highly-skilled basketball players in defended vs. undefended game situations. We predicted differences in quiet-eye duration as a function of skill and performance particularly resulting from late quiet-eye offsets...
July 14, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28699340/overcoming-pitfalls-in-boundary-elements-calculations-with-computer-simulations-of-ion-selective-membrane-electrodes
#10
Dajing Yuan, Eric Bakker
Finite difference analysis of ion-selective membranes is a valuable tool for understanding a range of time dependent phenomena such as response times, long and medium term potential drifts, determination of selectivity, and (re)conditioning kinetics. It is here shown that an established approach based on the diffusion layer model applied to an ion-exchange membrane fails to use mass transport to account for concentration changes at the membrane side of the phase boundary. Instead, such concentrations are imposed by the ion-exchange equilibrium condition, without taking into account the source of these ions...
July 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28681419/linear-and-nonlinear-relationships-between-body-mass-index-and-physical-fitness-in-brazilian-children-and-adolescents
#11
Vítor P Lopes, Marco Cossio-Bolaños, Rossana Gómez-Campos, Miguel de Arruda, Jefferson Eduardo Hespanhol, Luis P Rodrigues
OBJECTIVES: The purpose of this study was to evaluate the linear and curvilinear relationship between body mass index (BMI) and physical fitness in children and adolescents. METHODS: Participants were 4567 (2505 girls) children aged 6-16 years. Weight and height were measured and BMI was calculated and adjusted for age and sex using WHO z-scores. Physical fitness was evaluated with the following tests: Yo-Yo test, standing long jump, seated 2-kg medicine ball throw, and 20-m dash...
July 5, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28672065/lean-mass-explains-the-association-between-muscular-fitness-and-bone-outcomes-in-13-year-old-boys
#12
Esther Ubago-Guisado, Dimitris Vlachopoulos, Augusto César Ferreira de Moraes, Ana Torres-Costoso, Kelly Wilkinson, Brad Metcalf, Javier Sánchez-Sánchez, Leonor Gallardo, Luis Gracia-Marco
AIM: This study investigated the associations between fitness indices and bone outcomes in young males. METHODS: Data were collected between autumn and winter 2014-2015 on 121 males with a mean age of 13.1 ±0.1 years: 41 swimmers, 37 footballers, 29 cyclists and 14 non-athletes. Participants were recruited from athletic clubs and schools across South West England. Lean mass, areal bone mineral density and hip structural estimates were measured using dual-energy X-ray absorptiometry...
July 3, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28651798/cycling-to-school-and-body-composition-physical-fitness-and-metabolic-syndrome-in-children-and-adolescents
#13
Robinson Ramírez-Vélez, Antonio García-Hermoso, Cesar Agostinis-Sobrinho, Jorge Mota, Rute Santos, Jorge Enrique Correa-Bautista, Deisy Constanza Amaya-Tambo, Emilio Villa-González
OBJECTIVE: To evaluate the association between cycling to/from school and body composition, physical fitness, and metabolic syndrome among a sample of Colombian children and adolescents. STUDY DESIGN: During the 2014-2015 school year, we examined a cross-sectional component of the Association for muscular strength with early manifestation of cardiovascular disease risk factors among Colombian children and adolescents (FUPRECOL) study. Participants included 2877 youths (54...
June 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28634260/did-the-suicide-barrier-work-after-all-revisiting-the-bloor-viaduct-natural-experiment-and-its-impact-on-suicide-rates-in-toronto
#14
Mark Sinyor, Ayal Schaffer, Donald A Redelmeier, Alex Kiss, Yasunori Nishikawa, Amy H Cheung, Anthony J Levitt, Jane Pirkis
OBJECTIVE: This research aims to determine the long-term impact of the Bloor Street Viaduct suicide barrier on rates of suicide in Toronto and whether media reporting had any impact on suicide rates. DESIGN: Natural experiment. SETTING: City of Toronto, Canada; records at the chief coroner's office of Ontario 1993-2003 (11 years before the barrier) and 2004-2014 (11 years after the barrier). PARTICIPANTS: 5403 people who died by suicide in the city of Toronto...
June 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/28629863/the-unfolding-mechanism-of-monomeric-mutant-sod1-by-simulated-force-spectroscopy
#15
Mona Habibi, Jörg Rottler, Steven S Plotkin
Mechanical unfolding of mutated apo, disulfide-reduced, monomeric superoxide dismutase 1 protein (SOD1) has been simulated via force spectroscopy techniques, using both an all-atom (AA), explicit solvent model and a coarse-grained heavy-atom Gō (HA-Gō) model. The HA-Gō model was implemented at two different pulling speeds for comparison. The most-common sequence of unfolding in the AA model agrees well with the most-common unfolding sequence of the HA-Gō model, when the same normalized pulling rate was used...
June 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28612306/bone-density-and-body-composition-in-newly-licenced-professional-jockeys
#16
K A Jackson, M T Sanchez-Santos, A L MacKinnon, A Turner, K Kuznik, S Ellis, C Box, J Hill, M K Javaid, C Cooper, N K Arden, J L Newton
The primary objective is the description of bone mineral density (BMD) and body composition in newly licensed jockeys. One in three male, flat jockeys has a very low bone mineral density. Further research is needed to assess the short-term risk of fractures and long-term health implications of these findings. INTRODUCTION: Describe bone mineral density (BMD) and body composition in entry-level male and female, flat and jump jockeys in Great Britain. METHODS: Data was collected on jockeys applying for a professional jockey license between 2013 and 2015...
June 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28595399/modeling-the-nonlinear-dielectric-response-of-glass-formers
#17
U Buchenau
The recently developed pragmatical model of asymmetric double-well potentials with a finite lifetime is applied to nonlinear dielectric data in polar undercooled liquids. The viscous effects from the finite lifetime provide a crossover from the cooperative jumps of many molecules at short times to the motion of statistically independent molecules at long times. The model allows us to determine the size of cooperatively rearranging regions from nonlinear ω-data and throws new light on a known inconsistency between nonlinear ω and 3ω-signals for glycerol and propylene carbonate...
June 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28592487/electrostatic-control-of-dna-intersegmental-translocation-by-the-ets-transcription-factor-etv6
#18
Tam Vo, Shuo Wang, Gregory M K Poon, W David Wilson
To find their DNA target sites in complex solution environments containing excess heterogeneous DNA, sequence-specific DNA-binding proteins execute various translocation mechanisms known collectively as facilitated diffusion. For proteins harboring a single DNA contact surface, long-range translocation occurs by jumping between widely spaced DNA segments. We have configured biosensor-based surface plasmon resonance to directly measure the affinity and kinetics of this intersegmental jumping by the ETS-family transcription factor ETS variant 6 (ETV6)...
June 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28560342/how-birds-direct-impulse-to-minimize-the-energetic-cost-of-foraging-flight
#19
Diana D Chin, David Lentink
Birds frequently hop and fly between tree branches to forage. To determine the mechanical energy trade-offs of their bimodal locomotion, we rewarded four Pacific parrotlets with a seed for flying voluntarily between instrumented perches inside a new aerodynamic force platform. By integrating direct measurements of both leg and wing forces with kinematics in a bimodal long jump and flight model, we discovered that parrotlets direct their leg impulse to minimize the mechanical energy needed to forage over different distances and inclinations...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28542160/the-phylogeography-of-myotis-bat-associated-rabies-viruses-across-canada
#20
Susan Nadin-Davis, Noor Alnabelseya, M Kimberly Knowles
As rabies in carnivores is increasingly controlled throughout much of the Americas, bats are emerging as a significant source of rabies virus infection of humans and domestic animals. Knowledge of the bat species that maintain rabies is a crucial first step in reducing this public health problem. In North America, several bat species are known to be rabies virus reservoirs but the role of bats of the Myotis genus has been unclear due to the scarcity of laboratory confirmed cases and the challenges encountered in species identification of poorly preserved diagnostic submissions by morphological traits alone...
May 2017: PLoS Neglected Tropical Diseases
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