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Adiponectin, lung

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https://www.readbyqxmd.com/read/27886976/airway-and-serum-adipokines-after-allergen-and-diesel-exposure-in-a-controlled-human-crossover-study-of-atopic-adults
#1
Marabeth M Kramer, Jeremy A Hirota, Akshay Sood, Kay Teschke, Christopher Carlsten
Adipokines are mediators released from adipose tissue. These proteins are regarded as active elements of systemic and pulmonary inflammation, whose dysregulation can alter an individual's risk of developing allergic lung diseases. Despite this knowledge, adipokine responses to inhaled stimuli are poorly understood. We sought to measure serum and lung adiponectin, leptin, and resistin in an atopic adult study population following exposure to allergen and diesel exhaust (DE). Two types of lung samples including bronchoalveolar lavage (BAL) and bronchial wash (BW), and a time course of serum samples, were collected from the 18 subjects who participated in the randomized, double-blinded controlled human study...
November 9, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27807394/peroxisome-proliferator-activated-receptor-%C3%AE-reduces-endothelin-1-caused-cardiomyocyte-hypertrophy-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-and-adiponectin
#2
Hsu-Lung Jen, Po-Len Liu, Yung-Hsiang Chen, Wei-Hsian Yin, Jaw-Wen Chen, Shing-Jong Lin
Peroxisome proliferator-activated receptor α (PPARα) plays a role in the pathogenesis of cardiac hypertrophy, although its underlying mechanism remains unclear. The purpose of this study was to evaluate the effect of PPARα activation on endothelin-1- (ET-1-) caused cardiomyocyte hypertrophy and explore its underlying mechanisms. Human cardiomyocytes (HCMs) were cultured with or without ET-1, whereafter the inhibitory effects of fenofibrate, a PPARα activator, on cell size and adiponectin protein were tested...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27629528/endothelin-1-induced-cell-hypertrophy-in-cardiomyocytes-is-improved-by-fenofibrate-possible-roles-of-adiponectin
#3
Hsu-Lung Jen, Wei-Hsian Yin, Jaw-Wen Chen, Shing-Jong Lin
AIM: Previous studies demonstrated that endothelin-1 (ET-1) can significantly increase the cell size and stimulate adiponectin expression in cultured human cardiomyocytes (HCM). The aim of the present study was to investigate the effects of fenofibrate, a peroxisome proliferator-activated receptor-α (PPARα) activator, on cell hypertrophy and adiponectin expression in vitro and in a rat model of daunorubicin-induced cardiomyopathy. METHODS: The cultured human cardiomyocytes (HCM) were stimulated with or without ET-1...
September 15, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27567677/reduced-circulating-adiponectin-levels-are-associated-with-the-metabolic-syndrome-independently-of-obesity-lipid-indices-and-serum-insulin-levels-a-cross-sectional-study
#4
Agathi Ntzouvani, Elisabeth Fragopoulou, Demosthenes Panagiotakos, Christos Pitsavos, Smaragdi Antonopoulou
BACKGROUND: Given the increasing rate of overweight and the burden of metabolic syndrome (MetS) on cardiovascular disease development, better understanding of the syndrome is of great importance. Therefore, the objectives were to examine whether interleukin-6 (IL-6) and adiponectin are associated with MetS, and whether this association is mediated by components of the MetS. METHODS: During 2011-2012, 284 individuals (159 men, 53 ± 9 years, 125 women 52 ± 9 years) without cardiovascular disease, type 1 diabetes mellitus, high-grade inflammatory disease, living in the greater Athens area, Greece, participated in clinical examination...
August 27, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27516571/role-of-omentin-and-chemerin-in-metabolic-syndrome-and-tumor-diseases
#5
Błażej Szydło, Paweł Kiczmer, Elżbieta Świętochowska, Zofia Ostrowska
For the past few years adipokines have been a center of appreciation and interest. They are biologically active molecules causing pleiotropic effects. They assist in angiogenesis, adipose tissue metabolism and inflammation, and modulate tissue sensitivity for insulin. Adipokines are produced in adipose tissue, so an abnormal quantity of this tissue leads to impaired levels of these factors. Because of their different concentrations in various conditions, it would be plausible to use them as markers for individual conditions, such as obesity, type 2 diabetes mellitus, pancreatitis, gastric cancer, lung cancer or colon cancer...
August 12, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27513854/effect-of-obesity-on-acute-ozone-induced-changes-in-airway-function-reactivity-and-inflammation-in-adult-females
#6
William D Bennett, Sally Ivins, Neil E Alexis, Jihong Wu, Philip A Bromberg, Sukhdev S Brar, Gregory Travlos, Stephanie J London
We previously observed greater ozone-induced lung function decrements in obese than non-obese women. Animal models suggest that obesity enhances ozone-induced airway reactivity and inflammation. In a controlled exposure study, we compared the acute effect of randomized 0.4ppm ozone and air exposures (2 h with intermittent light exercise) in obese (N = 20) (30<BMI<40Kg/m2) vs. non-obese (N = 20) (BMI<25Kg/m2) non-smoking 18-35 year old women. We measured spirometry and bronchial reactivity to inhaled methacholine (3h post-exposure)...
2016: PloS One
https://www.readbyqxmd.com/read/27488495/adiposity-influences-airway-wall-thickness-and-the-asthma-phenotype-of-hiv-associated-obstructive-lung-disease-a-cross-sectional-study
#7
Julia H Barton, Alex Ireland, Meghan Fitzpatrick, Cathy Kessinger, Danielle Camp, Renee Weinman, Deborah McMahon, Joseph K Leader, Fernando Holguin, Sally E Wenzel, Alison Morris, Matthew R Gingo
BACKGROUND: Airflow obstruction, which encompasses several phenotypes, is common among HIV-infected individuals. Obesity and adipose-related inflammation are associated with both COPD (fixed airflow obstruction) and asthma (reversible airflow obstruction) in HIV-uninfected persons, but the relationship to airway inflammation and airflow obstruction in HIV-infected persons is unknown. The objective of this study was to determine if adiposity and adipose-associated inflammation are associated with airway obstruction phenotypes in HIV-infected persons...
2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27470682/evaluation-of-adiponectin-profile-in-italian-patients-affected-by-obstructive-sleep-apnea-syndrome
#8
Donato Lacedonia, Ersilia Nigro, Maria Gabriella Matera, Olga Scudiero, Maria Ludovica Monaco, Rita Polito, Giovanna Elisiana Carpagnano, Maria Pia Foschino Barbaro, Gennaro Mazzarella, Andrea Bianco, Aurora Daniele
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder; obesity represents a major risk factor for the development and progression of OSAS although obese patients do not necessarily suffer from OSAS. Adipose tissue communicates with lung in both physiologic and pathologic conditions through the production of adipokines, hormones active in metabolic and inflammatory processes. To explore the extent to which Acrp30 impacts on pathophysiology of OSAS and whether these proteins could be considered as targets for both diagnosis and therapy through enzyme-linked immunosorbent assay, western blotting analysis and fast protein liquid chromatography we have analyzed total levels as well as oligomer distribution in OSAS patients...
October 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27342876/hyperplasia-de-novo-lymphangiogenesis-and-lymphatic-regression-in-mice-with-tissue-specific-inducible-overexpression-of-murine-vegf-d
#9
Gabriela M Lammoglia, Carolynn E Van Zandt, Daniel X Galvan, Jose L Orozco, Michael T Dellinger, Joseph M Rutkowski
Lymphatic vessels modulate tissue fluid balance and inflammation and provide a conduit for endocrine and lipid transport. The growth of new lymphatic vessels in the adult, lymphangiogenesis, is predominantly mediated through vascular endothelial growth factor receptor-3 (VEGFR-3) signaling. We took advantage of the unique binding of murine VEGF-D specifically to VEGFR-3 and generated mice capable of inducible, tissue-specific expression of murine VEGF-D under a tightly-controlled tetracycline response element (TRE) promoter to stimulate adult tissue lymphangiogenesis...
August 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27337146/adipokines-asymmetrical-dimethylarginine-and-pulmonary-function-in-adolescents-with-asthma-and-obesity
#10
Fengyang Huang, Blanca Estela Del-Río-Navarro, Saúl Torres-Alcántara, José Alfredo Pérez-Ontiveros, Eliseo Ruiz-Bedolla, Omar Josué Saucedo-Ramírez, Santiago Villafaña, Fausto Sánchez-Muñoz, Guadalupe Bravo, Enrique Hong
OBJECTIVE: This study was to investigate whether the metabolic abnormalities of adipokines and asymmetrical dimethylarginine (ADMA) associate with pulmonary function deficits in adolescents with obesity and asthma. METHODS: This study enrolled 28 obese adolescents with asthma, 46 obese adolescents without asthma, 58 normal-weight adolescents with asthma, and 63 healthy control subjects. Serum levels of leptin, high-molecule-weight (HMW) adiponectin, retinol binding protein 4 (RBP4), asymmetrical dimethylarginine (ADMA), and pulmonary function were qualified...
June 23, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27240593/repeated-ozone-exposure-exacerbates-insulin-resistance-and-activates-innate-immune-response-in-genetically-susceptible-mice
#11
Jixin Zhong, Katryn Allen, Xiaoquan Rao, Zhekang Ying, Zachary Braunstein, Saumya R Kankanala, Chang Xia, Xiaoke Wang, Lori A Bramble, James G Wagner, Ryan Lewandowski, Qinghua Sun, Jack R Harkema, Sanjay Rajagopalan
BACKGROUND: Inhaled ozone (O3) has been demonstrated as a harmful pollutant and associated with chronic inflammatory diseases such as diabetes and vascular disorders. However, the underlying mechanisms by which O3 mediates harmful effects are poorly understood. OBJECTIVES: To investigate the effect of O3 exposure on glucose intolerance, immune activation and underlying mechanisms in a genetically susceptible mouse model. METHODS: Diabetes-prone KK mice were exposed to filtered air (FA), or O3 (0...
August 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27220901/adiponectin-ameliorates-the-apoptotic-effects-of-paraquat-on-alveolar-type%C3%A2-%C3%A2-cells-via-improvements-in-mitochondrial-function
#12
Yarong He, Liqun Zou, Yaxiong Zhou, Hai Hu, Rong Yao, Yaowen Jiang, Wayne Bond Lau, Tun Yuan, Wen Huang, Zhi Zeng, Yu Cao
Previous studies have demonstrated that excessive reactive oxygen/nitrogen species (ROS/RNS)‑induced apoptosis is an important feature of the injury to the lung epithelium in paraquat (PQ) poisoning. However the precise mechanisms of PQ‑induced dysfunction of the mitochondria, where ROS/RNS are predominantly produced, remain to be fully elucidated. Whether globular adiponectin (gAd), a potent molecule protective to mitochondria, regulates the mitochondrial function of alveolar type II cells to reduce PQ‑induced ROS/RNS production remains to be investigated...
July 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27079485/resistin-is-a-predictor-of-asthma-risk-and-resistin-adiponectin-ratio-is-a-negative-predictor-of-lung-function-in-asthma
#13
D Ballantyne, H Scott, L MacDonald-Wicks, P G Gibson, L G Wood
BACKGROUND: Adipokines, such as resistin and adiponectin, modify inflammation and may contribute to increased asthma risk and severity in obese people. OBJECTIVE: To examine plasma resistin and resistin:adiponectin ratio (i) in asthmatics compared to healthy controls, (ii) according to asthma severity, obesity and gender (iii) following weight loss in obese asthmatics. METHODS: In a cross-sectional observational study of asthmatic adults (n = 96) and healthy controls (n = 46), plasma resistin and adiponectin were measured...
August 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27036303/visceral-adiposity-is-associated-with-cytokines-and-decrease-in-lung-function-in-women-with-persistent-asthma
#14
A V Capelo, V M da Fonseca, M V M Peixoto, S R de Carvalho, C M Azevedo, M I G Elsas, B Marques
UNLABELLED: Abdominal obesity is associated with a risk of cardiovascular diseases, metabolic syndrome and decreased lung function. However, it is not known whether asthma control is influenced by the accumulation of adipose tissue in the various abdominal compartments. OBJECTIVE: To determine associations among abdominal adiposity distribution, asthma control, lung function and cytokines in women. METHODS AND DESIGN: In this cross-sectional study of asthmatic women, data on demographic variables, comorbid conditions, disease history, anthropometric and spirometric measurements were collected...
September 2016: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/26930652/triglyceride-glucose-body-mass-index-is-a-simple-and-clinically-useful-surrogate-marker-for-insulin-resistance-in-nondiabetic-individuals
#15
Leay-Kiaw Er, Semon Wu, Hsin-Hua Chou, Lung-An Hsu, Ming-Sheng Teng, Yu-Chen Sun, Yu-Lin Ko
BACKGROUND: Insulin resistance (IR) and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which contribute to the development of diabetes mellitus and cardiovascular diseases. We compared traditional lipid levels and ratios and combined them with fasting plasma glucose (FPG) levels or adiposity status for determining their efficiency as independent risk factors for IR. METHODS: We enrolled 511 Taiwanese individuals for the analysis...
2016: PloS One
https://www.readbyqxmd.com/read/26900794/autophagy-and-obesity-related-lung-disease
#16
Maria A Pabon, Kevin C Ma, Augustine M K Choi
Obesity-related disease is a significant source of premature death and economic burden globally. It is also a common comorbidity in patients suffering from lung disease, affecting both severity and treatment success. However, this complex association between obesity and the lung is poorly understood. Autophagy is a self-recycling homeostatic process that has been linked to beneficial or deleterious effects, depending on the specific lung disease. Obesity affects autophagy in a tissue-specific manner, activating autophagy in adipocytes and impairing autophagy in hepatocytes, immune cells, and pancreatic β-cells, among others...
May 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/26823558/gender-difference-in-plasma-fatty-acid-binding-protein-4-levels-in-patients-with-chronic-obstructive-pulmonary-disease
#17
Xue Zhang, Diandian Li, Hao Wang, Caishuang Pang, Yanqiu Wu, Fuqiang Wen
COPD (chronic obstructive pulmonary disease) is characterized by airway inflammation and increases the likelihood of the development of atherosclerosis. Recent studies have indicated that FABP4 (fatty-acid-binding protein 4), an intracellular lipid chaperone of low molecular mass, plays an important role in the regulation of inflammation and atherosclerosis. We carried out a preliminary clinical study aiming at investigating the relationships between circulating FABP4 levels in patients with COPD and inflammation and lung function...
2016: Bioscience Reports
https://www.readbyqxmd.com/read/26822630/pharmacodynamic-effects-of-low-dose-pioglitazone-in-patients-with-the-metabolic-syndrome-without-diabetes-mellitus
#18
Anh Vu, Lisa A Kosmiski, Amber L Beitelshees, Ronald Prigeon, Maha S Sidhom, Brooke Bredbeck, Julie Predhomme, Kimberly M Deininger, Christina L Aquilante
STUDY OBJECTIVE: To determine the effects of low-dose pioglitazone on plasma adipocyte-derived cytokines, high-sensitivity C-reactive protein (hs-CRP), and components of the metabolic syndrome in adults with the metabolic syndrome without diabetes mellitus. DESIGN: Prospective, randomized, double-blind, placebo-controlled study. SETTING: University of Colorado Clinical and Translational Research Center. PATIENTS: Thirty-two men and women, aged 30-60 years, without diabetes who had a clinical diagnosis of the metabolic syndrome, as defined by the American Heart Association/National Heart, Lung, and Blood Institute criteria...
March 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/26813452/serum-angiopoietin-like-4-is-over-expressed-in-copd-patients-association-with-pulmonary-function-and-inflammation
#19
Y-Q Wu, Y-C Shen, H Wang, J-L Zhang, D-D Li, X Zhang, T Wang, D Xu, B-W Ying, L-L Wang, F-Q Wen
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is both a pulmonary and systematic disease, which will cause abnormal expression of some circulating factors. Angiopoietin-like protein 4 (ANGPTL4) has been reported to play important role in inflammatory responses and several diseases. However, whether it contributes to COPD is an open question. The aim of this study is to explore the potential relationship between ANGPTL4 and COPD. PATIENTS AND METHODS: In this study, circulating levels of ANGPTL4, C-reactive protein (CRP), adiponectin, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9 and monocyte chemotactic protein (MCP)-1 in 73 COPD patients and 40 healthy volunteers were investigated using multiplex enzyme-linked immunosorbent assay Kits...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26708392/the-relationship-between-adiponectin-levels-and-epicardial-adipose-tissue-thickness-in-non-obese-children-with-asthma
#20
Cem Ozde, Mahmut Dogru, Firat Erdogan, Ilke Ozahi Ipek, Sukriye Ozde, Osman Karakaya
BACKGROUND: There is an association between adiponectin (APN) and asthma. However, the mechanisms underlying this association is unclear. APN is a predominantly anti-inflammatory protein with possible signalling activity in the lung that can be secreted by Epicardial Adipose Tissue (EAT). Our hypothesis is that serum APN levels may be directly and simply related to the amount of EAT accumulation, particularly when it is expressed as thickness in children with asthma. OBJECTIVE: The aim of this study was to investigate whether serum adiponectin (APN) and epicardial adipose tissue thickness (EATT) have an effect in non-obese children with asthma and in healthy non-asthmatic children, and analyze their relationships with clinical outcomes...
December 2015: Asian Pacific Journal of Allergy and Immunology
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