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https://www.readbyqxmd.com/read/28432078/effect-of-4-5-6-7-8-tetrahydro-5-5-8-8-tetramethyl-2-naphthalenyl-carbamoyl-benzoic-acid-am80-on-alveolar-regeneration-in-adiponectin-deficient-mice-showing-a-chronic-obstructive-pulmonary-disease-like-pathophysiology
#1
Hitomi Sakai, Michiko Horiguchi, Tomomi Akita, Chihiro Ozawa, Mai Hirokawa, Yuki Oiso, Harumi Kumagai, Yoshito Takeda, Isao Tachibana, Norikazu Maeda, Chikamasa Yamashita
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease that causes widespread and irreversible alveolar collapse. Although COPD occurs worldwide, only symptomatic therapy is currently available. The objective of the present study was the development of therapeutic agents to eradicate COPD. Therefore, we focused on 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl] benzoic acid (Am80), which is a derivative of all-trans retinoic acid. We evaluated the effects of Am80 on alveolar repair in a novel COPD model of adiponectin-deficient mice...
April 21, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28411906/serum-levels-of-adiponectin-and-leptin-in-asthmatic-patients-and-its-relation-with-asthma-severity-lung-function-and-bmi
#2
R Nasiri Kalmarzi, P Ataee, M Mansori, G Moradi, S Ahmadi, Z Kaviani, B Khalafi, W Kooti
INTRODUCTION: Asthma is one of the diseases which has a high prevalence in developed and developing countries. The relationship between asthma and obesity has always been focused by researchers. In this field, adipokines, especially adiponectin and leptin have highly attended by the scientist. The aim of this study was to determine the serum level of adiponectin, leptin and the leptin/adiponectin ratio in asthmatic patients and its relationship with disease severity, lung function and BMI (body mass index)...
May 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28382609/metabolic-syndrome-as-a-factor-affecting-systemic-inflammation-in-patients-with-chronic-obstructive-pulmonary-disease
#3
R Rubinsztajn, T Przybyłowski, M Maskey-Warzęchowska, M Paplińska-Goryca, P Nejman-Gryz, K Karwat, R Chazan
Chronic obstructive pulmonary disease (COPD) is a systemic disease which may be associated with other comorbidities. The aim of the study was to estimate the incidence of metabolic syndrome (MS) in COPD patients and to assess its impact on systemic inflammation and lung function. MS was diagnosed in accordance with the recommendations of the Polish Forum for the Prevention of Cardiovascular Diseases. The study group consisted of 267 patients with stable COPD in all stages of severity. All patients underwent spirometry with bronchial reversibility testing and 6 min walk test (6MWT)...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28356730/plasminogen-activator-inhibitor-1-is-elevated-in-patients-with-copd-independent-of-metabolic-and-cardiovascular-function
#4
Benjamin Waschki, Henrik Watz, Olaf Holz, Helgo Magnussen, Beata Olejnicka, Tobias Welte, Klaus F Rabe, Sabina Janciauskiene
INTRODUCTION: Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive pulmonary disease (COPD). The role of PAI-1 in COPD with respect to metabolic and cardiovascular functions is unclear. METHODS: In this study, which was nested within a prospective cohort study, the serum levels of PAI-1 were cross-sectionally measured in 74 stable COPD patients (Global Initiative for Chronic Obstructive Lung Disease [GOLD] Stages I-IV) and 18 controls without lung disease...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28344417/circulating-adiponectin-levels-following-treatment-can-predict-late-clinical-outcomes-in-chronic-heart-failure
#5
Ho-Ping Yu, Hsu-Lung Jen, Wei-Hsian Yin, Jeng Wei
BACKGROUND: Circulating adiponectin concentration increases in patients with chronic heart failure (HF). We sought to explore the prognostic value of temporal changes in adiponectin concentration following treatment for chronic HF. METHODS: Serum adiponectin levels were measured at baseline and after a 3-month anti-failure treatment in 124 patients with symptomatic chronic systolic HF. Major adverse cardiac events (MACE) including death, heart transplantation, or hospitalization with worsening HF during a median follow-up period of 752 days were determined...
March 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28317846/serum-and-synovial-fluid-lipidomic-profiles-predict-obesity-associated-osteoarthritis-synovitis-and-wound-repair
#6
Chia-Lung Wu, Kelly A Kimmerling, Dianne Little, Farshid Guilak
High-fat diet-induced obesity is a major risk factor for osteoarthritis (OA) and diminished wound healing. The objective of this study was to determine the associations among serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and wound healing in a pre-clinical obese mouse model of OA. Male C57BL/6 J mice were fed either a low-fat (10% kcal) or one of three high-fat (HF, 60% kcal) diets rich in saturated fatty acids (SFAs), ω-6 or ω-3 polyunsaturated FAs (PUFAs). OA was induced by destabilization of the medial meniscus...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115224/the-burden-of-obesity-in-asthma-and-copd-role-of-adiponectin
#7
REVIEW
Andrea Bianco, Ersilia Nigro, Maria Ludovica Monaco, Maria Gabriella Matera, Olga Scudiero, Gennaro Mazzarella, Aurora Daniele
The influence of obesity on development, severity and prognosis of both asthma and COPD is attracting growing interest. The impact of obesity on the respiratory system ranges from structural modifications (decline of total lung capacity) to humoral alterations. Adipose tissue strongly contributes to the establishment of an inflammatory state being an important source of adipokines. Amongst adipokines, adiponectin is an important component of organ cross talk with adipose tissue exerting protective effects on a variety of pathophysiological processes...
January 20, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28096201/serum-c-peptide-total-and-high-molecular-weight-adiponectin-and-pancreatic-cancer-do-associations-differ-by-smoking
#8
Leticia M Nogueira, Christina C Newton, Michael N Pollak, Debra T Silverman, Demetrius Albanes, Satu Männistö, Stephanie J Weinstein, Eric J Jacobs, Rachael Z Stolzenberg-Solomon
BACKGROUND: Studies examining associations between circulating concentrations of C-peptide and total adiponectin, two biomarkers related to obesity and insulin secretion and sensitivity and pancreatic ductal adenocarcinoma (PDA) risk have shown inconsistent results and included limited numbers of smokers. METHODS: We examined associations of these biomarkers and high molecular weight (HMW) adiponectin with PDA, overall, and by smoking status. We conducted a pooled nested case-control analysis in 3 cohorts (Prostate, Lung, Colorectal, and Ovarian Cancer Trial, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and Cancer Prevention Study-II), with 758 cases (435 current smokers) and 1052 controls (531 smokers) matched by cohort, age, sex, race, blood draw date and follow-up time...
January 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27936897/expression-profiles-and-associations-of-adiponectin-and-adiponectin-receptors-with-intramuscular-fat-in-tibetan-chicken
#9
R Zhang, Y Lin, L Zhi, H Liao, L Zuo, Z Li, Y Xu
1. Adiponectin and its receptors (ADIPOR1 and ADIPOR2) are novel endocrine systems that act at various levels to modulate glucose and lipid metabolism. This study was designed to investigate the spatial expression of adiponectin, ADIPOR1 and ADIPOR2 genes in various tissues in Tibetan chicken. The temporal expression of adiponectin and its receptor mRNAs were also studied in adipose tissue, breast muscle and thigh muscle and the correlations of the levels of adiponectin, ADIPOR1 and ADIPOR2 mRNA with the contents of intramuscular fat in breast muscle and thigh muscle of Tibetan chicken were determined...
April 2017: British Poultry Science
https://www.readbyqxmd.com/read/27886976/airway-and-serum-adipokines-after-allergen-and-diesel-exposure-in-a-controlled-human-crossover-study-of-atopic-adults
#10
Marabeth M Kramer, Jeremy A Hirota, Akshay Sood, Kay Teschke, Christopher Carlsten
Adipokines are mediators released from adipose tissue. These proteins are regarded as active elements of systemic and pulmonary inflammation, whose dysregulation can alter an individual's risk of developing allergic lung diseases. Despite this knowledge, adipokine responses to inhaled stimuli are poorly understood. We sought to measure serum and lung adiponectin, leptin, and resistin in an atopic adult study population following exposure to allergen and diesel exhaust (DE). Two types of lung samples including bronchoalveolar lavage (BAL) and bronchial wash (BW), and a time course of serum samples, were collected from the 18 subjects who participated in the randomized, double-blinded controlled human study...
November 9, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27807394/peroxisome-proliferator-activated-receptor-%C3%AE-reduces-endothelin-1-caused-cardiomyocyte-hypertrophy-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-and-adiponectin
#11
Hsu-Lung Jen, Po-Len Liu, Yung-Hsiang Chen, Wei-Hsian Yin, Jaw-Wen Chen, Shing-Jong Lin
Peroxisome proliferator-activated receptor α (PPARα) plays a role in the pathogenesis of cardiac hypertrophy, although its underlying mechanism remains unclear. The purpose of this study was to evaluate the effect of PPARα activation on endothelin-1- (ET-1-) caused cardiomyocyte hypertrophy and explore its underlying mechanisms. Human cardiomyocytes (HCMs) were cultured with or without ET-1, whereafter the inhibitory effects of fenofibrate, a PPARα activator, on cell size and adiponectin protein were tested...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27629528/endothelin-1-induced-cell-hypertrophy-in-cardiomyocytes-is-improved-by-fenofibrate-possible-roles-of-adiponectin
#12
Hsu-Lung Jen, Wei-Hsian Yin, Jaw-Wen Chen, Shing-Jong Lin
AIM: Previous studies demonstrated that endothelin-1 (ET-1) can significantly increase the cell size and stimulate adiponectin expression in cultured human cardiomyocytes (HCM). The aim of the present study was to investigate the effects of fenofibrate, a peroxisome proliferator-activated receptor-α (PPARα) activator, on cell hypertrophy and adiponectin expression in vitro and in a rat model of daunorubicin-induced cardiomyopathy. METHODS: The cultured human cardiomyocytes (HCM) were stimulated with or without ET-1...
September 15, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27567677/reduced-circulating-adiponectin-levels-are-associated-with-the-metabolic-syndrome-independently-of-obesity-lipid-indices-and-serum-insulin-levels-a-cross-sectional-study
#13
Agathi Ntzouvani, Elisabeth Fragopoulou, Demosthenes Panagiotakos, Christos Pitsavos, Smaragdi Antonopoulou
BACKGROUND: Given the increasing rate of overweight and the burden of metabolic syndrome (MetS) on cardiovascular disease development, better understanding of the syndrome is of great importance. Therefore, the objectives were to examine whether interleukin-6 (IL-6) and adiponectin are associated with MetS, and whether this association is mediated by components of the MetS. METHODS: During 2011-2012, 284 individuals (159 men, 53 ± 9 years, 125 women 52 ± 9 years) without cardiovascular disease, type 1 diabetes mellitus, high-grade inflammatory disease, living in the greater Athens area, Greece, participated in clinical examination...
August 27, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27516571/role-of-omentin-and-chemerin-in-metabolic-syndrome-and-tumor-diseases
#14
Błażej Szydło, Paweł Kiczmer, Elżbieta Świętochowska, Zofia Ostrowska
For the past few years adipokines have been a center of appreciation and interest. They are biologically active molecules causing pleiotropic effects. They assist in angiogenesis, adipose tissue metabolism and inflammation, and modulate tissue sensitivity for insulin. Adipokines are produced in adipose tissue, so an abnormal quantity of this tissue leads to impaired levels of these factors. Because of their different concentrations in various conditions, it would be plausible to use them as markers for individual conditions, such as obesity, type 2 diabetes mellitus, pancreatitis, gastric cancer, lung cancer or colon cancer...
August 12, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27513854/effect-of-obesity-on-acute-ozone-induced-changes-in-airway-function-reactivity-and-inflammation-in-adult-females
#15
William D Bennett, Sally Ivins, Neil E Alexis, Jihong Wu, Philip A Bromberg, Sukhdev S Brar, Gregory Travlos, Stephanie J London
We previously observed greater ozone-induced lung function decrements in obese than non-obese women. Animal models suggest that obesity enhances ozone-induced airway reactivity and inflammation. In a controlled exposure study, we compared the acute effect of randomized 0.4ppm ozone and air exposures (2 h with intermittent light exercise) in obese (N = 20) (30<BMI<40Kg/m2) vs. non-obese (N = 20) (BMI<25Kg/m2) non-smoking 18-35 year old women. We measured spirometry and bronchial reactivity to inhaled methacholine (3h post-exposure)...
2016: PloS One
https://www.readbyqxmd.com/read/27488495/adiposity-influences-airway-wall-thickness-and-the-asthma-phenotype-of-hiv-associated-obstructive-lung-disease-a-cross-sectional-study
#16
Julia H Barton, Alex Ireland, Meghan Fitzpatrick, Cathy Kessinger, Danielle Camp, Renee Weinman, Deborah McMahon, Joseph K Leader, Fernando Holguin, Sally E Wenzel, Alison Morris, Matthew R Gingo
BACKGROUND: Airflow obstruction, which encompasses several phenotypes, is common among HIV-infected individuals. Obesity and adipose-related inflammation are associated with both COPD (fixed airflow obstruction) and asthma (reversible airflow obstruction) in HIV-uninfected persons, but the relationship to airway inflammation and airflow obstruction in HIV-infected persons is unknown. The objective of this study was to determine if adiposity and adipose-associated inflammation are associated with airway obstruction phenotypes in HIV-infected persons...
August 4, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27470682/evaluation-of-adiponectin-profile-in-italian-patients-affected-by-obstructive-sleep-apnea-syndrome
#17
Donato Lacedonia, Ersilia Nigro, Maria Gabriella Matera, Olga Scudiero, Maria Ludovica Monaco, Rita Polito, Giovanna Elisiana Carpagnano, Maria Pia Foschino Barbaro, Gennaro Mazzarella, Andrea Bianco, Aurora Daniele
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder; obesity represents a major risk factor for the development and progression of OSAS although obese patients do not necessarily suffer from OSAS. Adipose tissue communicates with lung in both physiologic and pathologic conditions through the production of adipokines, hormones active in metabolic and inflammatory processes. To explore the extent to which Acrp30 impacts on pathophysiology of OSAS and whether these proteins could be considered as targets for both diagnosis and therapy through enzyme-linked immunosorbent assay, western blotting analysis and fast protein liquid chromatography we have analyzed total levels as well as oligomer distribution in OSAS patients...
October 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27342876/hyperplasia-de-novo-lymphangiogenesis-and-lymphatic-regression-in-mice-with-tissue-specific-inducible-overexpression-of-murine-vegf-d
#18
Gabriela M Lammoglia, Carolynn E Van Zandt, Daniel X Galvan, Jose L Orozco, Michael T Dellinger, Joseph M Rutkowski
Lymphatic vessels modulate tissue fluid balance and inflammation and provide a conduit for endocrine and lipid transport. The growth of new lymphatic vessels in the adult, lymphangiogenesis, is predominantly mediated through vascular endothelial growth factor receptor-3 (VEGFR-3) signaling. We took advantage of the unique binding of murine VEGF-D specifically to VEGFR-3 and generated mice capable of inducible, tissue-specific expression of murine VEGF-D under a tightly-controlled tetracycline response element (TRE) promoter to stimulate adult tissue lymphangiogenesis...
August 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27337146/adipokines-asymmetrical-dimethylarginine-and-pulmonary-function-in-adolescents-with-asthma-and-obesity
#19
Fengyang Huang, Blanca Estela Del-Río-Navarro, Saúl Torres-Alcántara, José Alfredo Pérez-Ontiveros, Eliseo Ruiz-Bedolla, Omar Josué Saucedo-Ramírez, Santiago Villafaña, Fausto Sánchez Muñoz, Guadalupe Bravo, Enrique Hong
OBJECTIVE: This study was to investigate whether the metabolic abnormalities of adipokines and asymmetrical dimethylarginine (ADMA) associate with pulmonary function deficits in adolescents with obesity and asthma. METHODS: This study enrolled 28 obese adolescents with asthma, 46 obese adolescents without asthma, 58 normal-weight adolescents with asthma, and 63 healthy control subjects. Serum levels of leptin, high-molecule-weight (HMW) adiponectin, retinol binding protein 4 (RBP4), asymmetrical dimethylarginine (ADMA), and pulmonary function were qualified...
March 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27240593/repeated-ozone-exposure-exacerbates-insulin-resistance-and-activates-innate-immune-response-in-genetically-susceptible-mice
#20
Jixin Zhong, Katryn Allen, Xiaoquan Rao, Zhekang Ying, Zachary Braunstein, Saumya R Kankanala, Chang Xia, Xiaoke Wang, Lori A Bramble, James G Wagner, Ryan Lewandowski, Qinghua Sun, Jack R Harkema, Sanjay Rajagopalan
BACKGROUND: Inhaled ozone (O3) has been demonstrated as a harmful pollutant and associated with chronic inflammatory diseases such as diabetes and vascular disorders. However, the underlying mechanisms by which O3 mediates harmful effects are poorly understood. OBJECTIVES: To investigate the effect of O3 exposure on glucose intolerance, immune activation and underlying mechanisms in a genetically susceptible mouse model. METHODS: Diabetes-prone KK mice were exposed to filtered air (FA), or O3 (0...
August 2016: Inhalation Toxicology
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