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https://www.readbyqxmd.com/read/27516199/small-molecules-targeting-kinases-involved-in-pulmonary-hypertension-a-patent-review-2010-2015
#1
REVIEW
Rita Morigi, Mirella Rambaldi, Alessandra Locatelli, Alberto Leoni
BACKGROUND: Despite the fact that in recent years, a substantial progress has been made in the treatment of pulmonary hypertension, it is still a severe disease characterized by poor prognosis, and the search for new drugs remains a priority. Current remedies address mainly the vasoconstrictor/ vasodilator imbalance in the pulmonary circulation, while the causes of the disease are only moderately affected. Recently, the role of receptor and non receptor kinases in pulmonary hypertension has emerged and these targets were extensively considered for the development of new therapeutic strategies...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27291780/bacillus-clausii-and-gut-homeostasis-state-of-the-art-and-future-perspectives
#2
Loris R Lopetuso, Franco Scaldaferri, Francesco Franceschi, Antonio Gasbarrini
INTRODUCTION: The intestinal barrier is a complex system responsible for the host health. Many gastrointestinal and extra-intestinal diseases are associated to gut barrier disruption. An increasing interest on nutritional supplements and functional foods focused on the hypothesis that specific prebiotics and probiotics may modulate and interact with gut barrier, re-establishing gut homeostasis. AREAS COVERED: The application of preparations containing B. clausii in the treatment or prevention of gut phisiology impairment has been largely supported in the last years and has driven its clinical applications...
August 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/25953947/-alterations-in-populations-of-t-lymphocytes-in-the-rats-blood-during-experimental-preeclampsia
#3
A Sharashenidze, L Kikalishvili, T Sanikidze
Immune tolerance to the fetus is predetermined mainly by HLA-G expression in trophoblasts, varying the ratio of Th1 / Th2, decrease in the content of cytotoxic T lymphocytes and natural killer cells (NK cells) and fusion "tread" of antibodies. The aim of the study was to establish the role of the placental hypoxia in regulation of expression of -lymphocytes populations in the blood of rats at different stages of pregnancy. For the purpose of modeling of PE in pregnant rats, at10-th day of gestation the lumen of the abdominal aorta below the renal artery was narrowed by the silk thread a third of its diameter (0...
April 2015: Georgian Medical News
https://www.readbyqxmd.com/read/25842870/-correlation-between-macro-and-micro-stability-c-h-2-domains-of-human-igg2-and-their-biological-activity-ii-calculation-of-thermodynamic-functions-characterizing-domains-stability
#4
V M Tishchenko
The thermodynamic parameters of the stabilization of the native structure C(H)2 domains of human myeloma immunoglobulin LOM and SIN second subclass and their firstly obtained hFc fragments were determined using the methods of scanning microcalorimenry. A decrease in the termal stability and energy stability of the native of these domains in the intact proteins correlated in the "phisiological" range of temperatures (20-37 degrees C), mainly, with entropy factor.
September 2014: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/24031994/heavy-metal-tolerance-cr-ag-and-hg-in-bacteria-isolated-from-sewage
#5
Agostinho A Lima de Silva, Márcia A Ribeiro de Carvalho, Sérgio A L de Souza, Patrícia M Teixeira Dias, Renato G da Silva Filho, Carmen S de Meirelles Saramago, Cleonice A de Melo Bento, Ernesto Hofer
Samples of sewage from a university hospital and a chemistry technical school were analysed for the percentage of bacterial tolerance to chromium (Cr), silver (Ag) and mercury (Hg). Additionally, we investigated the effect of these metals on pigmentation and on some enzymatic activities of the metal tolerant strains isolated, as well as antimicrobial resistance in some metal tolerant Enterobacteriaceae strains. Tolerance to Cr was observed mainly in Gram positive bacteria while in the case of Ag and Hg the tolerant bacteria were predominately Gram negative...
October 2012: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/22185845/-development-of-radioimmunoassay-and-its-consequences-in-the-medical-research-a-tribute-to-rosalyn-yallow
#6
EDITORIAL
Arturo Zárate, Leticia Manuel
Rosalyn Yalow lived all her life in the Bronx, New York, where she was born, educated, worked and met Solomon Berson, her scientific partner for a long time. Despite being a top student at Hunter College she was unable to be admitted to any graduate program in physics, mainly because she was Jewish and female. Later she joined the Veterans Administration Hospital in New York where she established the radioisotope laboratory. There she met Solomon Berson and formed the extraordinary scientific partnership and started publishing studies of radioactivity...
September 2011: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/21062259/pi3k-akt-mtor-inhibitors-in-ovarian-cancer
#7
REVIEW
M Mazzoletti, M Broggini
Phisiological activation of PI3K pathway is necessary for cells to regulate many different physiological processes such as transcription, protein synthesis, metabolic responses and membrane trafficking. Abnormal activation of the PI3K pathway leads to an increased activity resulting in tumor onset, maintenance, progression and invasion. Both genetic and epigenetic alterations could affect the normal pathway's activation. Ovarian cancer is the leading cause of death from gynaecological malignancies in the western world...
2010: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/20557015/-pathogenesis-and-diagnosis-of-subclinical-hepatic-encephalopathy
#8
REVIEW
Irena Ciećko-Michalska, Tomasz Mach, Agnieszka Słowik
Subclinical hepatic encephalopathy (SHE) is a serious clinical problem in patiens with liver damage and precise pathophisiological mechanisms resonsible for encephalopathy are not fully understood. Is definied as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction after exclusion of other known brain disease. Recent date have shown that increased CNS (central nervous system) ammonia concentration and presence of mild diffuse brain oedema plays a key role in the pathogenesis of SHE...
2010: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/19137972/-excipients-influence-on-properites-of-thermosensitive-carriers-containing-methotrexate
#9
Bozena Karolewicz, Janusz Pluta
The physicochemical properties of thermosensitive formulations obtained on the basis of Pluronic F127 containing methotrexate are differentiated and depends on kind of additives and their concentration. To the effect of obtaining drug form which would satisfy requrements of pharmacopeia and for assurance of optimal physicochemical parameters values of formulation to their obtaining was used of excipients which bring to phisiological osmotic pressure, substances increasing of visosity, benzalkonium chloride as preservative substance and substances influencing on release of methotrexate form drug form...
2008: Polimery W Medycynie
https://www.readbyqxmd.com/read/18001885/prediction-of-respiratory-measurements-based-on-cross-embedding-techniques
#10
Suren I Rathnayake, Udantha R Abeyratne
Measurements of multiple physiological signals are required for diagnostic procedures such as for sleep disordered breathing. Accuracy of automated diagnostic procedures and home based screening methods can be affected when phisiological measurements contains artifacts or signal losses. We investigate on predicting one physiological signal measurement from others, using dependencies exists in physiological signals, in order to obtain a measure of reliability to the measurements. Modeling such relationships are done with the use of artificial neural networks...
2007: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/17453714/determination-of-ligand-binding-capacity-of-soluble-fc-gamma-rii-and-fc-gamma-riii-in-sera-of-patients-with-sle
#11
Istvan Csipo, Sandor Barath, Emese Kiss, Gabriella Szucs, Gyula Szegedi, Maria Kavai
BACKGROUND: Soluble, human low affinity Fcgamma receptors, such as sFcgammaRII and sFcgammaRIII, are known to play a pathologic role in different diseases. Sandwich ELISAs had previously been applied for the specific detection and determination of these soluble receptors. In these ELISAs, commercial monoclonal antibodies (Ab) were used as capture antibodies with monoclonal or polyclonal antibodies serving as detector Abs. Increased levels of cell-free FcgammaRIII have been detected in patients with lupus but the functions and levels of sFcgammaRII have not been fully characterized yet...
May 2007: Autoimmunity
https://www.readbyqxmd.com/read/17179597/-effects-of-ultracaine-on-the-local-blood-flow-of-the-gum-and-on-the-development-of-cerebral-seizures-in-experiment
#12
N A Tsilosani, N P Mitagvariia, M G Devdariani, I G Bilanishvili, Z I Nanobashvili
We have studied the effect of ultracaine DS forte on local blood flow of the rat gum as well as on the development of the convulsion activity of the brain at systemic injection. Experiments were carried out on 12 mongrel albino mail rats of 200-250 g weight. In the I group of animals under the light chloral hydrate anesthesia we studied the changes of local blood flow in the rat gum of lower jaw after ultracaine DS forte injection (right side) and the similar quantity of phisiological solution (left side). According to our data, in the right gum, the rate of local blood flow decreases statistically significantly at 18%, while the injection of physiological solution did not result in any changes...
November 2006: Georgian Medical News
https://www.readbyqxmd.com/read/15532900/-significance-of-the-mathematical-model-of-cardiac-electrical-field-for-the-interpretation-of-experimental-data
#13
M Mlcek, O Kittnar
BACKGROUND: In concurrence of our recent findings of the elevation of QT dispersion (QTd) in the group of pregnant women, mathematical approaches were developed aimed to give possible geometrical explanation whether the observed changes result from the rotation or from the changed position of the heart. METHODS AND RESULTS: Mathematical model of the cardiac electrical field approximated as a time variable dipole in a homogenous spatial conductor was developed. From the experimental vectocardiographic records, representing time course of the cardiac dipole, body surface potential maps were calculated on the basis of the model...
2004: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/15168659/-effect-of-antioxidants-in-women-with-increased-risk-of-preeclampsia-the-role-of-oxidative-stress-in-preeclampsia
#14
REVIEW
M Gicheva, K Chukanov, V Mazneĭkova, S Ivanov
New frontiers have been opened lately in the understanding of the patho-phisiology of preeclampsia thus giving new directions in the process of therapy of this condition. Oxidative stress is a condition characterized by peroxidants predominating over antioxidants. Numerous intensive studies are carried out to reveal the role of oxidative stress in the pathogenesis of preeclampsia.
2004: Akusherstvo i Ginekologii︠a︡
https://www.readbyqxmd.com/read/12666036/-statistical-poisson-motor-unit-number-estimation-methodological-aspects-and-normal-results-in-the-extensor-digitorum-brevis-muscle-of-healthy-subjects
#15
L Murga Oporto, C Menéndez-de León, E Bauzano Poley, M J Núñez-Castaín
INTRODUCTION: Among the differents techniques for motor unit number estimation (MUNE) there is the statistical one (Poisson), in which the activation of motor units is carried out by electrical stimulation and the estimation performed by means of a statistical analysis based on the Poisson s distribution. OBJECTIVES: The study was undertaken in order to realize an approximation to the MUNE Poisson technique showing a coprehensible view of its methodology and also to obtain normal results in the extensor digitorum brevis muscle (EDB) from a healthy population...
April 1, 2003: Revista de Neurologia
https://www.readbyqxmd.com/read/10655784/-phorbols-chemical-synthesis-and-chemical-biology
#16
REVIEW
M Shibasaki
The phorbol esters, such as phorbol 12- myristate 13-acetate (PMA), are known to be powerful tumor promoters and activators of protein kinase C (PKC). First discovered by Nishizuka et al., PKC is a phospholipid- and calcium-dependent serine/threonine kinase, phisiologically activated by 1,2-diacyl-sn-glycerol (DAG). PKC is also known to be an important target for other structurally diverse tumor promoters such as ingenols, teleocidins, and aplysiatoxins. Structure-activity analyses of a variety of analogs of DAG and these tumor promoters have been carried out...
January 2000: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/9503920/-tuberculosis-yesterday-today-tomorrow
#17
A G Khomenko
The historical aspects of phisiology are briefly outlined. The main factors that promote the prevalence of tuberculosis are characterized. The present-day tuberculosis epidemiological situation makes one to correct antituberculous measures and with the use of new investigations and developments to improve the identification of patients with tuberculosis, primarily those with contagious types of the disease, to introduce the currently available short-term regimens of 2-stage drug therapy, to design novel agents and depot formulations of the well known ones...
1997: Problemy Tuberkuleza
https://www.readbyqxmd.com/read/8548675/-the-knowledge-on-health-and-the-social-sciences
#18
REVIEW
E C Jarillo Soto, M G Arroyave Loaiza
In this paper the main question is about the health complete interpretation. It is an epistemological discussion. It starts with the obstacles in the comprehension from several sciences (i.e. phisiology, epidemiology, and sociology) about the health as a social and collective problem. The point is how to do the research and the conceptual interpretation. Finally, the authors explain theirs point of view: the most important is the nature and specificity of the objet health. Not view disciplinary. They show a model to understand the analysis of the health from the social sciences perspective...
May 1995: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/6651010/-advances-in-the-treatment-of-endotoxic-shock
#19
R Rodríguez López, P Torres Tortosa, C Lorca Cano, J Rodríguez Caamaño, E Martínez Villalta, M Rodríguez Penalver, T Rodríguez Costa
Authors present their adopted measures, in the different clinical stages of endotoxic shock with a phisiological approach, paying special attention to those secondary to meningococcal infections.
September 1983: Anales Españoles de Pediatría
https://www.readbyqxmd.com/read/1190904/-value-of-interacardiac-recordings-in-the-evaluation-of-positive-qrs-in-v1-provoked-by-stimulation-of-the-right-ventricle
#20
A Castellanos, Beltrán-Baguena, B Befeler, A S Agha, R J Myerburg
The analysis of the common bundle and of the ventrical filtered electrograms has incrased our knowledge of the intraventricular conduction following the simulation of the PVS as well as the different types or reciprocating that can be produced by premature beats. 2. The positive QRS complexes in V1 produced from PVD by St2 can be explained as a greater degree of incomplete recuperation of the right ventricular wall than in the interventricular septum. In contrast with what happened in the basal beats, where the front took longer to reach the TSVD than the VI...
September 1975: Archivos del Instituto de Cardiología de México
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