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https://www.readbyqxmd.com/read/29307079/functional-changes-of-orexinergic-reaction-to-psychoactive-substances
#1
REVIEW
Vincenzo Monda, Monica Salerno, Francesco Sessa, Renato Bernardini, Anna Valenzano, Gabriella Marsala, Christian Zammit, Roberto Avola, Marco Carotenuto, Giovanni Messina, Antonietta Messina
It is becoming increasingly apparent the importance of the central nervous system (CNS) as the major contributor to the regulation of systemic metabolism. Antipsychotic drugs are used often to treat several psychiatric disorders, including schizophrenia and bipolar disorder However, antipsychotic drugs prescription, particularly the second-generation ones (SGAs), such as clozapine and olanzapine, is related to a considerable weight gain which usually leads to obesity. The aim of this paper is to assess the influence of orexin A on sympathetic and hyperthermic reactions to several neuroleptic drugs...
January 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/28950817/specific-patient-features-affect-antiepileptic-drug-therapy-decisions-focus-on-gender-age-and-psychiatric-comorbidities
#2
Laura Rosa Pisani, Marina Nikanorova, Cecilie Johannessen Landmark, Svein Ivar Johannessen, Francesco Pisani
BACKGROUND: Patient features, apart from the type of seizures/epilepsy, affect markedly antiepileptic drug (AED) choice and dosage. The present review focuses on gender, age and psychiatric comorbidities which play a leading role in influencing antiepileptic treatment. METHODS: Reviews with large population of patients, controlled clinical trials, observational investigations, experimental studies and experimental reviews of experimental data, where appropriated, were analysed and illustrated to produce the most homogeneous indications possible...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/19700142/-diabetes-and-second-generation-atypical-antipsychotics
#3
REVIEW
S Chabroux, E Haffen, A Penfornis
Schizophrenia is a common psychiatric illness (1% of the general population), characterized by the association of positive and negative symptoms and cognitive disorders. Antipsychotics, typical or atypical, are known to induce in patients with schizophrenia weight gain and abnormalities in glucose and lipid metabolisms. These modifications, in addition to metabolic risk factors, intrinsic to the psychiatric illness (physical inactivity, smoking, diabetes), increase the risk of cardiovascular complications. Some antipsychotics are associated with a higher risk of metabolic disorders...
September 2009: Annales D'endocrinologie
https://www.readbyqxmd.com/read/19494443/delusion-symptoms-and-response-to-antipsychotic-treatment-are-associated-with-the-5-ht2a-receptor-polymorphism-102t-c-in-alzheimer-s-disease-a-3-year-follow-up-longitudinal-study
#4
Francesco Angelucci, Sergio Bernardini, Paolo Gravina, Lorenza Bellincampi, Alberto Trequattrini, Fulvia Di Iulio, Diego Vanni, Giorgio Federici, Carlo Caltagirone, Paola Boss├╣, Gianfranco Spalletta
Although the etiology of psychotic symptoms (hallucinations and delusions) in Alzheimer's disease is still not known, alterations in serotonergic neurotransmission have been proposed. In a 3-year follow-up study, we evaluated the association of serotonin (5-HT) receptor 5-HT2a 102T/C polymorphism (allelic variants CC, CT and TT) with psychotic symptom severity and response to treatment with atypical antipsychotics (risperidone, olanzapine and quietapine) in 80 patients with a diagnosis of probable Alzheimer's disease...
2009: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/10598295/-new-antipsychotic-agents
#5
REVIEW
J P Olie, S Ghaoui, F J Bayle
Since the discovery of the neuroleptics in 1952, french psychiatrists have proposed a classification of neuroleptics taking into account the pharmalogical and therapeutic differences between these drugs. They distinguished three different clinical effects of neuroleptics: sedative effects, effects on the positive symptoms of schizophrenia and effects on the negative symptoms. However these agents have many side effects including the extrapyramidal syndrome (EPS), akathisia, dystonia and parkinsonism. These side effects occur in up to 75% of patients receiving typical neuroleptics and are the main cause of non-compliance...
November 1999: L'Enc├ęphale
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