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https://www.readbyqxmd.com/read/28230285/modeling-lung-surfactant-interactions-with-benzo-a-pyrene
#1
Jacek Korchowiec, Anna Stachowicz-Kusnierz, Sonia Trojan, Lukasz Cwiklik, Beata Korchowiec
By reducing surface tension of the air-water interface in alveoli, lung surfactant (LS) is crucial for proper functioning of the lungs. It also forms the first barrier against inhaled pathogens. In this study we inspect the interactions of LS models with a dangerous air pollutant, benzo[a]pyrene (BaP). DPPC, POPC and their 1:1 mixture are used as LS models. Pressure-area isotherms are employed to study macroscopic properties of the monolayers. We find that addition of BaP has a condensing effect, manifested by lowering the values of surface pressure and shifting the isotherms to smaller areas...
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28221959/efficacy-of-ozonation-treatments-of-smoked-fish-for-reducing-its-benzo-a-pyrene-concentration-and-toxicity
#2
Irina Rozentale, Janis Ancans, Elena Bartkiene, Arturs Viksna, Vadims Bartkevics
Ozone is widely used in food processing, for example, to decompose mycotoxins or pesticide residues, to extend the shelf life of products, and for sanitation. The objective of this study was to assess the possibility of expanding the application of ozone for oxidative degradation of polycyclic aromatic hydrocarbons (PAHs). The evaluation was conducted by ozonation of a benzo[a]pyrene (BaP) standard solution and smoked fish (sprats) contaminated with PAHs. The effect of ozonation was immediate in the BaP solution; 89% of this toxic compound was decomposed after only 1 min of treatment...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28216010/uptake-of-benzo-a-pyrene-but-not-of-phenanthrene-is-inhibited-by-fatty-acids-in-intestinal-brush-border-membrane-vesicles-of-rainbow-trout-oncorhynchus-mykiss
#3
Stefan de Gelder, Liselot van Och, Jan Zethof, Thamar N M Pelgrim, Josef D Rasinger, Gert Flik, Marc H G Berntssen, Peter H M Klaren
Partial replacement of fish ingredients with vegetable ingredients has elevated levels of polycyclic aromatic hydrocarbons (PAHs) in Atlantic salmon reared on these feeds. PAH uptake in the intestinal tract is postulated to occur in association with lipid absorption and could well be affected by fatty acid composition. We therefore investigated the effects of a fish oil and vegetable oil fatty acid, eicosapentaenoic acid (EPA; 20:5n-3) and oleic acid (18:1n-9) respectively, on the uptake of benzo[a]pyrene (BaP) and phenanthrene (PHE) across the intestinal brush border membrane in the salmonid species rainbow trout (Oncorhynchus mykiss)...
February 12, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28213838/brief-report-autism-like-traits-are-associated-with-enhanced-ability-to-disembed-visual-forms
#4
Antoinette Sabatino DiCriscio, Vanessa Troiani
Atypical visual perceptual skills are thought to underlie unusual visual attention in autism spectrum disorders. We assessed whether individual differences in visual processing skills scaled with quantitative traits associated with the broader autism phenotype (BAP). Visual perception was assessed using the Figure-ground subtest of the Test of visual perceptual skills-3rd Edition (TVPS). In a large adult cohort (n = 209), TVPS-Figure Ground scores were positively correlated with autistic-like social features as assessed by the Broader autism phenotype questionnaire...
February 17, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28211339/phytoextraction-of-contaminated-urban-soils-by-panicum-virgatum-l-enhanced-with-application-of-a-plant-growth-regulator-bap-and-citric-acid
#5
Matthew Aderholt, Dale L Vogelien, Marina Koether, Sigurdur Greipsson
Lead (Pb) contamination in soil represents a threat to human health. Phytoextraction has gained attention as a potential alternative to traditional remediation methods because of lower cost and minimal soil disruption. The North American native switchgrass (Panicum virgatum L.) was targeted due to its ability to produce high biomass and grow across a variety of ecozones. In this study switchgrass was chemically enhanced with applications of the soil-fungicide benomyl, chelates (EDTA and citric acid), and PGR to optimize phytoextraction of Pb and zinc (Zn) from contaminated urban soils in Atlanta, GA...
February 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28209279/neolignan-and-megastigmane-glucosides-from-the-aerial-parts-of-isodon-japonicus-with-cell-protective-effects-on-bap-induced-cytotoxicity
#6
Takahiro Matsumoto, Seikou Nakamura, Souichi Nakashima, Tomoe Ohta, Keiko Ogawa, Masashi Fukaya, Junko Tsukioka, Tomohiro Hasei, Tetsushi Watanabe, Hisashi Matsuda
Six neolignan glucosides, named isodonosides I-VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolignan and megastigmane glucosides were determined by derivatizations, by ECD (electronic circular dicroism) Cotton effect approximation, and by the modified Mosher's method...
February 13, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28203639/determination-of-kinetic-bioconcentration-in-mussels-after-short-term-exposure-to-polycyclic-aromatic-hydrocarbons
#7
Ledicia Rey-Salgueiro, Elena Martínez-Carballo, Antonio Cid, Jesús Simal-Gándara
The kinetic bioconcentration of N-heterocyclic aromatic hydrocarbons and polycyclic aromatic hydrocarbons in mussels (Mytilus galloprovincialis) after short waterborne exposure was studied. Benzo[a]pyrene (BaP), its analogue azaarene 10-azabenzo[a]pyrene (AzaBaP), and their mixture (Mix), were selected to monitor the changes in water concentrations over three days. Decay of both PAHs concentrations in water after 24 h of waterborne exposure to mussels at levels of 10 and 100 μg/L follows a first order kinetic with half-lives of 4-5 h, with residual levels of PAHs below 7%...
January 2017: Heliyon
https://www.readbyqxmd.com/read/28196686/starch-enhanced-degradation-of-hmw-pahs-by-fusarium-sp-in-an-aged-polluted-soil-from-a-coal-mining-area
#8
Ou-Ya Zhao, Xue-Na Zhang, Sheng-Dong Feng, Li-Xiu Zhang, Wei Shi, Zhi-Xin Yang, Miao-Miao Chena, Xue-Dan Fanga
The present study used strain ZH-H2 (Fusarium sp.) isolated by our group as the PAH-degrading strain and 5-6-rings PAHs as degradation objects. The soil incubation experiment was carried out to investigate the starch-enhanced degradation effects of HMW PAHs by Fusarium sp. in an Aged Polluted Soil from a Coal Mining Area. The results showed that the removal rates of BaP, InP and BghiP increased with increasing inoculation rate of ZH-H2 in the unsterile aged polluted soil of coal mining area, with the exception of BbF degradation which increased in the H2 treatment and then decreased...
December 28, 2016: Chemosphere
https://www.readbyqxmd.com/read/28193466/three-dimensional-ionic-liquid-functionalized-magnetic-graphene-oxide-nanocomposite-for-the-magnetic-dispersive-solid-phase-extraction-of-16-polycyclic-aromatic-hydrocarbons-in-vegetable-oils
#9
Yun Zhang, Hua Zhou, Zhe-Hua Zhang, Xiang-Lun Wu, Wei-Guo Chen, Yan Zhu, Chun-Fu Fang, Yong-Gang Zhao
In this paper, a novel three-dimensional ionic liquid functionalized magnetic graphene oxide nanocomposite (3D-IL@mGO) was prepared, and used as an effective adsorbent for the magnetic dispersive solid phase extraction (MSPE) of 16 polycyclic aromatic hydrocarbons (PAHs) in vegetable oil prior to gas chromatography-mass spectrometry (GC-MS). The properties of 3D-IL@mGO were characterized by scanning electron micrographs (SEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM). The 3D-IL@mGO, functionalized by ionic liquid, exhibited high adsorption toward PAHs...
February 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28187971/polycyclic-aromatic-hydrocarbons-pahs-in-wild-marine-organisms-from-south-china-sea-occurrence-sources-and-human-health-implications
#10
Chang-Liang Ke, Yang-Guang Gu, Qi Liu, Liu-Dong Li, Hong-Hui Huang, Nan Cai, Zhi-Wei Sun
Concentrations of 16 US EPA priority polycyclic aromatic hydrocarbons (PAHs) were measured in 15 marine wild organism species from South China Sea. The concentration (dry weight) of 16 PAHs ranged from 94.88 to 557.87ng/g, with a mean of 289.86ng/g. The concentrations of BaP in marine species were no detectable. The composition of PAHs was characterized by the 2- and 3-ring PAHs in marine species, and NA, PHE and FA were the dominant constituents. PAHs isomeric ratios indicated PAHs mainly originated from grass, wood and coal combustion, and petroleum...
February 7, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28187968/biodegradation-of-the-benzo-a-pyrene-contaminated-sediment-of-the-jiaozhou-bay-wetland-using-pseudomonas-sp-immobilization
#11
Xin Jin, Weijun Tian, Qing Liu, Kaili Qiao, Jing Zhao, Xiaoxi Gong
To remove benzo[a]pyrene (BaP) that has accumulated in the Jiaozhou Bay wetland sediment, two strains (JB1 and JB2) were selected from the BaP-contaminated the wetland sediment and immobilized in coal cinder and chitosan beads using entrapping and surface adsorption methods. Biodegradation of BaP in sediment was carried out in pots. The results showed that, supported by the coal cinder and chitosan beads, 71.9, 65.5, 58.9 and 66.1% of the BaP in the immobilized cells was degraded after 40d. These percentages were clearly higher than the 47...
February 8, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28181029/smoking-modify-the-effects-of-polycyclic-aromatic-hydrocarbons-exposure-on-oxidative-damage-to-dna-in-coke-oven-workers
#12
Jin Yang, Hongjie Zhang, Huitao Zhang, Wubin Wang, Yanli Liu, Yanfeng Fan
PURPOSE: Coke oven emissions containing polycyclic aromatic hydrocarbons (PAHs) are predominant toxic constituents of particulate air pollution that have been linked to increased risk of lung cancer. Numerous epidemiological studies have suggested that oxidative DNA damage may play a pivotal role in the carcinogenic mechanism of lung cancer. Little is known about the effect of interaction between PAHs exposure and lifestyle on DNA oxidative damage. METHODS: The study population is composed by coke oven workers (365) and water treatment workers (144), and their urinary levels of four PAH metabolites and 8-hydroxydeoxyguanosine (8-OHdG) were determined...
February 8, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28166650/the-effects-of-exercise-load-during-development-on-oxidative-stress-levels-and-antioxidant-potential-in-adulthood
#13
S Lee, J Hashimoto, T Suzuki, A Satoh
The objective of this study was to elucidate the impact of physical activity during the growth period as well as on oxidative stress and antioxidative potential in adulthood. The experimental animals used were four-week old male Wistar rats, which were randomly divided into three groups. The exercise loads were as follows: control (CON), treadmill exercise (TE), and jumping exercise (JE). The exercise was performed at the same time of day, at a frequency of five days per week, for eight weeks. Derivatives of reactive oxygen metabolites (d-ROSs) and biological antioxidant potential (BAP) were measured during periods of rest prior to commencement of the experiment and after the experiment...
February 6, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28165035/microbial-nitrification-denitrification-and-respiration-in-the-leached-cinnamon-soil-of-the-upper-basin-of-miyun-reservoir
#14
Wen Xu, Yan-Peng Cai, Zhi-Feng Yang, Xin-An Yin, Qian Tan
Leached cinnamon soil is the main agricultural soil distributed in the North China Plain. In this research, leached cinnamon soil samples were collected in the upper basin of Miyun Reservoir (northeast of Beijing, China). The BaPS method (Barometric Process Separation) was applied to measure nitrification, denitrification and respiration rates. The rates of nitrification, denitrification and respiration were 0-120.35 μg N/kg SDW h, 0-246.86 μg N/kg SDW h and 0.17-225.85 μg C/kg SDW h (Soil Dry Weight, SDW), respectively...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163282/potential-objective-biomarkers-for-fatigue-among-working-women
#15
Chie Ebata, Hitomi Tatsuta, Masayuki Tatmeichi
OBJECTIVE: The prediction of health impairment due to work overload is subjectively assessed based on recognized symptoms; however, objective evaluation is primarily ideal in the field of occupational health. Recently, some biomarkers of autonomic function and/or oxidative stress were reported to be associated with fatigue. This study aimed to preliminarily investigate whether these biomarkers could be objective indicators for fatigue and stress among working women. METHOD: Participants included 118 full-time female workers (mean age 37...
February 4, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28145857/cytotoxicity-study-of-benzo-a-pyrene-on-blood-cells-of-wistar-rat-in-vitro
#16
J Zhang, Y Liu, S-Z Wei
The effect of benzo[a]pyrene (BaP) on Wistar rat lymphocyte activity, lymphocyle membrane integrity and erythrocytes hemolysis were examined using the MTT assay, the release of the lactate dehydrogenase (LD) and the hemoglobin release respectively in vitro. The results showed that lymphocyte activity had no remarkable response to BaP after a low dose of exposure. But the membrane change was found after higher dose of BaP exposure, and the significant release of LD was observed. The release of LD increased with exposure time prolonging and exposure dose increasing...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28134597/endogenous-bone-morphogenetic-protein-2-plays-a-role-in-vascular-smooth-muscle-cell-calcification-induced-by-interleukin-6-in-vitro
#17
Mingshu Sun, Qing Chang, Miaomiao Xin, Qian Wang, Hua Li, Jiaqi Qian
Systemic inflammation is involved in vascular calcification and cardiovascular disease which is the leading cause of mortality in rheumatoid arthritis (RA). A high level of serum interleukin (IL)-6 plays a key role in local and systemic inflammation in RA. However, the underlying mechanisms remain unclear. We established a human umbilical artery smooth muscle cell (HUASMC) culturing method to investigate the possible role of IL-6 on vascular calcification. HUASMCs were obtained from umbilical arteries of healthy neonates...
January 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28131956/evaluation-of-the-biofilm-forming-ability-and-its-associated-genes-in-staphylococcus-species-isolates-from-bovine-mastitis-in-argentinean-dairy-farms
#18
Verónica Felipe, Carolina A Morgante, Paola S Somale, Florencia Varroni, María L Zingaretti, Romina A Bachetti, Silvia G Correa, Carina Porporatto
Staphylococcus aureus and coagulase-negative staphylococci (CNS) are important causes of intramammary infection in dairy cattle, and their ability to produce biofilm is considered an important virulence property in the pathogenesis of mastitis. However, the published date on mechanisms and factors involved in infection persistence in the mammary gland remains unclear. The aim of this study was to investigate whether the main Staphylococcus species involved in bovine intramammary infections possess specific characteristics that promote colonization of the udder...
January 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28115713/global-long-range-transport-and-lung-cancer-risk-from-polycyclic-aromatic-hydrocarbons-shielded-by-coatings-of-organic-aerosol
#19
Manish Shrivastava, Silja Lou, Alla Zelenyuk, Richard C Easter, Richard A Corley, Brian D Thrall, Philip J Rasch, Jerome D Fast, Staci L Massey Simonich, Huizhong Shen, Shu Tao
Polycyclic aromatic hydrocarbons (PAHs) have toxic impacts on humans and ecosystems. One of the most carcinogenic PAHs, benzo(a)pyrene (BaP), is efficiently bound to and transported with atmospheric particles. Laboratory measurements show that particle-bound BaP degrades in a few hours by heterogeneous reaction with ozone, yet field observations indicate BaP persists much longer in the atmosphere, and some previous chemical transport modeling studies have ignored heterogeneous oxidation of BaP to bring model predictions into better agreement with field observations...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28111842/detoxification-of-benzo-a-pyrene-primarily-depends-on-cytochrome-p450-while-bioactivation-involves-additional-oxidoreductases-including-5-lipoxygenase-cyclooxygenase-and-aldo-keto-reductase-in-the-liver
#20
Liupeng Wang, Wenwei Xu, Leilei Ma, Suxing Zhang, Kezhi Zhang, Peizhen Ye, Guozhen Xing, Xuefeng Zhang, Yiyi Cao, Jing Xi, Jun Gu, Yang Luan
Cytochrome P450s are involved in detoxification and activation of benzo[a]pyrene (BaP) with unclear balance and unknown contribution of other oxidoreductases. Here, we investigated the BaP and BaP-induced mutagenicity in hepatic and extra-hepatic tissues using hepatic P450 reductase null (HRN) gpt mice. After 2-week treatment (50 mg/kg, i.p. 4 days), BaP in the liver and lung of HRN-gpt mice were increased. BaP promoted gpt mutant frequency (MF) in HRN-gpt mice liver. MF of gpt in the lung and Pig-a in hematopoietic cells induced by BaP in HRN-gpt mice were increased than in gpt mice...
January 23, 2017: Journal of Biochemical and Molecular Toxicology
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