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https://www.readbyqxmd.com/read/29785915/the-effects-of-a-synthetic-analogue-of-the-bovine-appeasing-pheromone-on-milk-yield-and-composition-in-valdostana-dairy-cows-during-the-move-from-winter-housing-to-confined-lowland-pastures
#1
Maria Cristina Osella, Alessandro Cozzi, Claudio Spegis, Germano Turille, Andrea Barmaz, Céline Lafont Lecuelle, Eva Teruel, Cécile Bienboire-Frosini, Camille Chabaud, Laurent Bougrat, Patrick Pageat
This Research Communication describes the effects of a synthetic analogue of the Bovine Appeasing Pheromone (BAP) on milk parameters in Valdostana dairy cows during the first turning out from tie-stalls to confined lowland pastures around the farms. Thirty healthy lactating Valdostana cows were enroled in the study and randomly divided into 2 groups: experimental group (EG, n = 15) and control group (CG, n = 15). The two groups were separately housed in the same farm and managed outside in two different pens...
May 2018: Journal of Dairy Research
https://www.readbyqxmd.com/read/29783938/biochemical-and-molecular-characterisation-of-exogenous-cytokinin-application-on-grain-filling-in-rice
#2
Binay Bhushan Panda, Sudhanshu Sekhar, Sushant Kumar Dash, Lamboder Behera, Birendra Prasad Shaw
BACKGROUND: Poor filling of grains in the basal spikelets of large size panicles bearing numerous spikelets has been a major limitation in attempts to increase the rice production to feed the world's increasing population. Considering that biotechnological intervention could play important role in overcoming this limitation, the role of cytokinin in grain filling was investigated based on the information on cell proliferating potential of the hormone and reports of its high accumulation in immature seeds...
May 21, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29774093/distribution-of-virulence-associated-genes-and-antimicrobial-susceptibility-in-clinical-acinetobacter-baumannii-isolates
#3
Chao Liu, Yaowen Chang, Ying Xu, Yun Luo, Linrong Wu, Zhanjun Mei, Shigang Li, Rui Wang, Xu Jia
Acinetobacter baumannii is undoubtedly one of the most clinically significant pathogens. The multidrug resistance and virulence potential of A. baumannii are responsible for hospital-acquired nosocomial infections. Unlike numerous investigations on the drug-resistant epidemiology of A. baumanni , virulence molecular epidemiology is less studied. Here, we collected 88 A. baumannii clinical isolates, tested their antimicrobial susceptibility to 10 commonly used antibiotics and analyzed the distribution of 9 selected virulence-associated genes, aims to investigate the primary characteristics of the virulence-associated genes that exist in clinically multidrug resistant (MDR) and non-MDR isolates of A...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29772428/lncrna-h19-interacts-with-s-adenosylhomocysteine-hydrolase-to-regulate-line-1-methylation-in-human-lung-derived-cells-exposed-to-benzo-a-pyrene
#4
Ye Fu, Wubin Wang, Xuejing Li, Yanli Liu, Yingying Niu, Bin Zhang, Jisheng Nie, Baolong Pan, Ruisheng Wang, Jin Yang
Benzo [a]pyrene (BaP) have been demonstrated to induce lung cancer risk in humans and many different animal models, with aberrant gene methylation as one of the epigenetic errors; however, the molecular mechanisms remain unclear. Here, we used three types of human lung-derived cells with BaP exposure as a model and attempted to investigate the long non-coding RNA (lncRNA) H19/S-adenosylhomocysteine hydrolase (SAHH) pathway that regulates gene methylation in vitro exposure to BaP. Results showed that compared to the controls, BaP-treated cells H19 expressions were increased in a dose- and time-dependent manner, whereas SAHH protein expressions were decreased...
May 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29771999/growth-medium-dependent-antimicrobial-activity-of-early-stage-mep-pathway-inhibitors
#5
Sara Sanders, David Bartee, Mackenzie J Harrison, Paul D Phillips, Andrew T Koppisch, Caren L Freel Meyers
The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathways. In one such pathway, the methylerythritol phosphate (MEP) pathway, which is essential for production of isoprenoids in bacterial pathogens, relatively little is known about the influence of growth environment on antibacterial properties of inhibitors targeting enzymes in this pathway...
2018: PloS One
https://www.readbyqxmd.com/read/29764288/occurrence-of-parent-and-substituted-polycyclic-aromatic-hydrocarbons-in-typical-wastewater-treatment-plants-and-effluent-receiving-rivers-of-beijing-and-risk-assessment
#6
Wei Cao, Meng Qiao, Bochuan Liu, Xu Zhao
Sixteen polycyclic aromatic hydrocarbons (PAHs) and some typical substituted polycyclic aromatic hydrocarbons (SPAHs) were investigated in wastewater treatment plants (WWTPs) and effluent effluent-receiving rivers in order to indentify the elimination of these compounds in WWTPs, as well as the potantial potential risk in the effluent-receiving rivers. The concentrations of ΣPAHs in the total phase (combined dissolved and adsorbed phases) in influent were between 944.1 and 1246.5 ng·L-1 , and ΣSPAHs, including methyl PAHs (MPAHs) and oxygenated PAHs (OPAHs), between 684...
May 15, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29763363/a-pilot-study-of-a-culturally-grounded-breastfeeding-intervention-for-pregnant-low-income-african-american-women
#7
Rebecca Reno
BACKGROUND: Increasing breastfeeding rates among low-income African American women may work toward the achievement of health equity. The dynamic breastfeeding assessment process (D-BAP) is a community-grounded, equity-focused intervention designed to increase prenatal breastfeeding self-efficacy. Research aim: The aims of the pilot study were (a) to determine the effect of the D-BAP on breastfeeding self-efficacy among pregnant, low-income African American women, (b) to examine the findings among women with no previous breastfeeding experience, and (c) to compare the findings between women with prior breastfeeding experience and those without it...
May 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29758891/benzo-a-pyrene-degradation-and-bioaccumulation-in-soil-plant-system-under-artificial-contamination
#8
Svetlana Sushkova, Irina Deryabkina, Elena Antonenko, Ridvan Kizilkaya, Vishnu Rajput, Galina Vasilyeva
The involvement of benzo[a]pyrene (BaP) one of the most toxic polycyclic aromatic hydrocarbons (PAHs) in the soil-plant system causes its potential carcinogenicity and mutagenicity for human health. The aim of this article is benzo[a]pyrene (BaP) degradation and bioaccumulation in soil-plant system under artificial contamination in model experiment with Haplic Chernozem and that spiked with various doses of BaP (20, 200, 400 and 800μgkg-1 ) equivalent to 1, 10, 20 and 40 levels of maximal permissible concentrations (MPC) planted with spring barley (Hordeum sativum distichum)...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29755321/voltage-gated-calcium-channel-activation-by-backpropagating-action-potentials-downregulates-nmdar-function
#9
Anne-Kathrin Theis, Balázs Rózsa, Gergely Katona, Dietmar Schmitz, Friedrich W Johenning
The majority of excitatory synapses are located on dendritic spines of cortical glutamatergic neurons. In spines, compartmentalized Ca2+ signals transduce electrical activity into specific long-term biochemical and structural changes. Action potentials (APs) propagate back into the dendritic tree and activate voltage gated Ca2+ channels (VGCCs). For spines, this global mode of spine Ca2+ signaling is a direct biochemical feedback of suprathreshold neuronal activity. We previously demonstrated that backpropagating action potentials (bAPs) result in long-term enhancement of spine VGCCs...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29754063/transcriptional-responses-of-acropora-hyacinthus-embryo-under-the-benzo-a-pyrene-stress-by-deep-sequencing
#10
Rong Xiao, Hailong Zhou, Chien-Min Chen, Huamin Cheng, Hongwu Li, Jia Xie, Hongwei Zhao, Qian Han, Xiaoping Diao
Coral embryos are a critical and sensitive period for the early growth and development of coral. Benzo(a)pyrene (BaP) is widely distributed in the ocean and has strong toxicity, but there is little information on the toxic effects to coral embryos exposed to this widespread environmental contaminant. Thus, in this study, we utilized the Illumina Hiseq™ 4000 platform to explore the gene response of Acropora hyacinthus embryos under the BaP stress. A total of 130,042 Unigenes were obtained and analyzed, and approximately 37...
April 24, 2018: Chemosphere
https://www.readbyqxmd.com/read/29753250/levels-and-risk-assessment-of-hydrocarbons-and-organochlorines-in-aerosols-from-a-north-african-coastal-city-bizerte-tunisia
#11
Badreddine Barhoumi, Javier Castro-Jiménez, Catherine Guigue, Madeleine Goutx, Richard Sempéré, Abdelkader Derouiche, Amani Achour, Soufiane Touil, Mohamed Ridha Driss, Marc Tedetti
The aim of this study was to assess, for the first time, the concentrations, sources, dry deposition and human health risks of polycyclic aromatic hydrocarbons (PAHs), aliphatic hydrocarbons (AHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in total suspended particle (TSP) samples collected in Bizerte city, Tunisia (North Africa), during one year (March 2015-January 2016). Concentrations of PAHs, AHs, PCBs and OCPs ranged 0.5-17.8 ng m-3 , 6.7-126.5 ng m-3 , 0.3-11 pg m-3 and 0...
May 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29753248/embryonic-exposure-to-benzo-a-pyrene-inhibits-reproductive-capability-in-adult-female-zebrafish-and-correlation-with-dna-methylation
#12
Dongxu Gao, Jing Lin, Kunlin Ou, Ying Chen, Hongbin Li, Qinhua Dai, Zhenni Yu, Zhenghong Zuo, Chonggang Wang
This study was conducted to investigate the effects of embryonic short-term exposure to benzo(a)pyrene (BaP), a model polycyclic aromatic hydrocarbon, on ovarian development and reproductive capability in adult female zebrafish. In 1-year-old fish after embryonic exposure to BaP for 96 h, the gonadosomatic indices and the percentage of mature oocytes were significantly decreased in the 0.5, 5 and 50 nmol/L treatments. The spawned egg number, the fertilization rate and the hatching success were significantly reduced, while the malformation rate of the F1 unexposed larvae were increased...
May 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29753057/histomorphologic-spectrum-of-germline-related-and-sporadic-bap-1-inactivated-melanocytic-tumors
#13
Erin M Garfield, Kara E Walton, Victor L Quan, Timothy VandenBoom, Bin Zhang, Betty Y Kong, Maria Cristina Isales, Elnaz Panah, Gene Kim, Pedram Gerami
BACKGROUND: BAP-1 inactivated melanocytic tumors (BIMTs) are often the earliest sign of the BAP-1 tumor predisposition syndrome. Identification of BIMTs and selection of patients for germline testing impacts the lives of patients with germline BAP-1 mutations. OBJECTIVE: We describe the spectrum of histomorphologic findings in BAP-1 inactivated melanocytic lesions to improve their recognition. We determined the frequency of sporadic versus germline cases in our cohort, assessing whether any features were statistically linked to germline status...
May 9, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29751397/microplastic-accumulation-patterns-and-transfer-of-benzo-a-pyrene-to-adult-zebrafish-danio-rerio-gills-and-zebrafish-embryos
#14
Annika Batel, Flora Borchert, Hannes Reinwald, Lothar Erdinger, Thomas Braunbeck
Since only a few studies have investigated effects of microplastics (MPs) by routes other than ingestion, this study was designed to analyze the accumulation patterns and transfer of toxic substances associated with microplastic exposure by simple attachment to (1) adult zebrafish (Danio rerio) gills and (2) zebrafish embryos. Two sizes of fluorescently labelled polymers (1-5 and 10-20 μm) loaded with the model polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BaP) were used to analyze fate, accumulation and transfer of microplastic-associated persistent organic pollutants (POPs) on gills and embryos...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29750188/temperature-effect-on-phase-state-and-reactivity-controls-atmospheric-multiphase-chemistry-and-transport-of-pahs
#15
Qing Mu, Manabu Shiraiwa, Mega Octaviani, Nan Ma, Aijun Ding, Hang Su, Gerhard Lammel, Ulrich Pöschl, Yafang Cheng
Polycyclic aromatic hydrocarbons like benzo( a )pyrene (BaP) in atmospheric particulate matter pose a threat to human health because of their high carcinogenicity. In the atmosphere, BaP is mainly degraded through a multiphase reaction with ozone, but the fate and atmospheric transport of BaP are poorly characterized. Earlier modeling studies used reaction rate coefficients determined in laboratory experiments at room temperature, which may overestimate/underestimate degradation rates when applied under atmospheric conditions...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29749523/overexpression-of-annexin-a1-protects-against-benzo-a-pyrene%C3%A2-induced-bronchial-epithelium-injury
#16
Yanfei Cui, Shengya Yang
The incidence of asthma is increasing worldwide. Bronchial epithelium injury is common in asthma. The regulatory role of Annexin A1 (ANXA1) in bronchial epithelium injury is currently not well understood. The aim of the present study was to evaluate the role of ANXA1 on bronchial epithelium injury. The cell viability and levels of apoptosis were respectively tested by Cell Counting Kit‑8 and flow cytometry. Reactive oxygen species (ROS) content and the activity of oxidative indicators were assessed by commercial kits...
May 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29746904/benzo-a-pyrene-promotes-migration-invasion-and-metastasis-of-lung-adenocarcinoma-cells-by-upregulating-tgif
#17
Haiyan Yang, Hongsheng Zhang, Teng Pan, Haiyu Wang, Yadong Wang
This study aimed to investigate the potential roles of TG-interacting factor (TGIF) in benzo(a)pyrene (BaP)-induced migration, invasion, and metastasis of lung adenocarcinoma cells. Cells were treated with different concentrations of BaP. MTT assays were used to measure cell proliferation. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunoblots were applied to measure the TGIF expression. A dual-luciferase reporter gene assay was performed to assess the effects of BaP on TGIF promoter-driven reporter gene expression...
May 7, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29738693/cytochrome-p450-1a1-cyp1a1-catalyzes-lipid-peroxidation-of-oleic-acid-induced-hepg2-cells
#18
B Huang, J Bao, Y-R Cao, H-F Gao, Y Jin
Nonalcoholic fatty liver disease (NAFLD) is a chronic hepatic disease associated with excessive accumulation of lipids in hepatocytes. As the disease progresses, oxidative stress plays a pivotal role in the development of hepatic lipid peroxidation. Cytochrome P450 1A1 (CYP1A1), a subtype of the cytochrome P450 family, has been shown to be a vital modulator in production of reactive oxygen species. However, the exact role of CYP1A1 in NAFLD is still unclear. The aim of this study was to investigate the effects of CYP1A1 on lipid peroxidation in oleic acid (OA)-treated human hepatoma cells (HepG2)...
May 2018: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29731598/broader-autism-phenotype-in-parents-of-children-with-autism-a-systematic-review-of-percentage-estimates
#19
Eric Rubenstein, Devika Chawla
The broader autism phenotype (BAP) is a collection of sub-diagnostic autistic traits more common in families of individuals with autism spectrum disorder (ASD) than in the general population. BAP is a latent construct that can be defined using different domains, measured using multiple instruments, and reported using different techniques. Therefore, estimates of BAP may vary greatly across studies. Our objective was to systematically review studies that reported occurrence of BAP in parents of children with ASD in order to quantify and describe heterogeneity in estimates...
June 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29729569/enhanced-organic-contaminants-accumulation-in-crops-mechanisms-interactions-with-engineered-nanomaterials-in-soil
#20
Xiang Wu, Wei Wang, Lizhong Zhu
The mechanism of enhanced accumulation of organic contaminants in crops with engineered nanomaterials (ENMs) were investigated by co-exposure of crops (Ipomoea aquatica Forsk (Swamp morning-glory), Cucumis sativus L. (cucumber), Zea mays L. (corn), Spinacia oleracea L. (spinach) and Cucurbita moschata (pumpkin))to a range of chemicals (polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs) and polybrominated diphenyl ether (PBDE)) and ENMs (TiO2 , Ag, Al2 O3 , graphene, carbon nanotubes (CNTs)) in soil...
May 2, 2018: Environmental Pollution
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