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https://www.readbyqxmd.com/read/28445420/vitamin-d-and-calcium-are-required-during-denosumab-treatment-in-osteoporosis-with-rheumatoid-arthritis
#1
Yukio Nakamura, Takako Suzuki, Tomohiko Yoshida, Hideshi Yamazaki, Hiroyuki Kato
The aim of this 12-month retrospective study was to evaluate differences in the outcomes of denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients having osteoporosis (OP) with rheumatoid arthritis (RA). Patients were divided into the denosumab monotherapy group (denosumab group, 22 cases) or denosumab plus vitamin D supplementation group (combination group, 21 cases). We measured serum bone alkaline phosphatase (BAP), N-terminal propeptide of type 1 collagen (P1NP), tartrate-resistant acid phosphatase (TRACP)-5b, and urinary N-terminal telopeptide of type-I collagen (NTX) at baseline, 1 week, and 1, 2, 4, 6, 8, and 12 months...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28444933/synergistic-effect-of-carbon-nuclei-and-polyaromatic-hydrocarbons-on-respiratory-and-immune-responses
#2
Pratiti H Chowdhury, Gaku Kitamura, Akiko Honda, Takahiro Sawahara, Tomohiro Hayashi, Wataru Fukushima, Hitomi Kudo, Sho Ito, Seiichi Yoshida, Takamichi Ichinose, Kayo Ueda, Hirohisa Takano
Particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5 ) is generally composed of carbon nuclei associated with various organic carbons, metals, ions and biological materials. Among these components, polyaromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BaP) and quinones have detrimental effects on airway epithelial cells and immunodisrupting effects, which leads to the exacerbation of respiratory allergies. The effects of PAHs and the carbon nuclei, separately as well as in combination, remain to be established...
April 26, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28444597/biodegradation-of-pyrene-and-benzo-a-pyrene-in-the-liquid-matrix-and-soil-by-a-newly-identified-raoultella-planticola-strain
#3
Lifeng Ping, Qian Guo, Xiaoyang Chen, Xiaoli Yuan, Chunrong Zhang, Hua Zhao
In the current study, the PL7 strain was isolated from soil and identified as Raoultella planticola based on its physiological characteristics and 16S rDNA sequence. By the 10th day, the PL7 strain degraded 52.0% of the pyrene (PYR) content and 50.8% of the benzo[a]pyrene (BaP) content in 20 mg L(-1) PYR and 10 mg L(-1) BaP in the liquid matrix. The half-life of PYR and BaP by PL7 degradation was 8.59 and 9.46 days, respectively. At pH 8.0, the degradation rates of PYR and BaP by PL7 were significantly higher at 30 °C than at 20 and 40 °C...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28441608/phylogenetic-signals-in-detoxification-pathways-in-cyprinid-and-centrarchid-species-in-relation-to-sensitivity-to-environmental-pollutants
#4
Peter van den Hurk, Lindsay E Gerzel, Peter Calomiris, Dennis C Haney
Observations in a previous study on biomarker responses in fish collected from urban creeks in Greenville, SC, indicated that there might be considerable differences in the expression of biotransformation enzymes in chub and sunfish species. To further investigate these species differences a dosing experiment was performed in which bluehead and creek chub (Nocomis leptocephalus and Semotilus atromaculatus), and redbreast sunfish, pumpkinseed, and bluegill (Lepomis auritus, L. gibbosus, and L. macrochirus) were injected with benzo[a]pyrene (BaP) as a model compound for common pollutants in urban creeks...
April 13, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28428138/pregnane-x-receptor-regulates-the-ahr-cyp1a1-pathway-and-protects-liver-cells-from-benzo-%C3%AE-pyrene-induced-dna-damage
#5
Hongmei Cui, Xinsheng Gu, Jingshu Chen, Ying Xie, Sui Ke, Jing Wu, Andrei Golovko, Benjamin Morpurgo, Chunhong Yan, Timothy D Phillips, Wen Xie, Jianyuan Luo, Zhijun Zhou, Yanan Tian
Pregnane X receptor (PXR) plays an important role in protecting cells from mutagenic DNA damages induced by endogenous and exogenous toxicants. This protective function is often attributed to the PXR-regulated metabolic detoxification. Here we report a novel potential mechanism that PXR reduces benzo-[α]-pyrene(BaP)-induced DNA damage through inhibiting the transcriptional activity of aryl hydrocarbon receptor (AhR) which plays a pivotal role in the bioactivation of BaP. We have utilized three well-characterized cell lines, i...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28426078/an-intravascular-bioartificial-pancreas-device-ibap-with-silicon-nanopore-membranes-snm-for-islet-encapsulation-under-convective-mass-transport
#6
Shang Song, Charles Blaha, Willieford Moses, Jaehyun Park, Nathan Wright, Joey Groszek, William Fissell, Shant Vartanian, Andrew M Posselt, Shuvo Roy
Diffusion-based bioartificial pancreas (BAP) devices are limited by poor islet viability and functionality due to inadequate mass transfer resulting in islet hypoxia and delayed glucose-insulin kinetics. While intravascular ultrafiltration-based BAP devices possess enhanced glucose-insulin kinetics, the polymer membranes used in these devices provide inadequate ultrafiltrate flow rates and result in excessive thrombosis. Here, we report the silicon nanopore membrane (SNM), which exhibits a greater hydraulic permeability and a superior pore size selectivity compared to polymer membranes for use in BAP applications...
April 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28421372/vascular-development-of-the-grapevine-vitis-vinifera-l-inflorescence-rachis-in-response-to-flower-number-plant-growth-regulators-and-defoliation
#7
Aude M Gourieroux, Bruno P Holzapfel, Margaret E McCully, Geoffrey R Scollary, Suzy Y Rogiers
The grapevine inflorescence is a determinate panicle and as buds emerge, shoot, flower and rachis development occur simultaneously. The growth and architecture of the rachis is determined by genetic and environmental factors but here we examined the role of flower and leaf number as well as hormones on its elongation and vascular development. The consequences of rachis morphology and vascular area on berry size and composition were also assessed. One week prior to anthesis, Merlot and Cabernet Sauvignon field vines were exposed to manual flower removal, exogenous plant growth regulators or pre-bloom leaf removal...
April 18, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28421317/effect-of-oral-carbohydrate-with-amino-acid-solution-on-serum-oxidative-anti-oxidative-status-in-healthy-volunteers
#8
Yasuo M Tsutsumi, Takuro Oyama, Nami Kakuta, Yousuke T Horikawa, Katsuyoshi Kume, Yoko Sakai, Rie Tsutsumi, Katsuya Tanaka
The aim of this work was to investigate the effect of oral carbohydrate with amino acid [oral nutritional supplement (ONS)] solution on oxidative stress in healthy persons. Fourteen healthy volunteers were segregated into control and ONS groups. Volunteers in the ONS group ingested 250 ml of Arginaid Water (Nestle Japan, Tokyo, Japan) in the evening before the experiment and at 7:00 am on the day of the experiment. Volunteers in the control group fasted after dinner and drank only water until 7:00 am on the day of the experiment...
April 18, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28407590/exposure-to-lethal-levels-of-benzo-a-pyrene-or-cadmium-trigger-distinct-protein-expression-patterns-in-earthworms-eisenia-fetida
#9
Lihao Zhang, Xiaochen Duan, Nannan He, Xu Chen, Jinli Shi, Weiming Li, Li Xu, Huixin Li
Different pollutants induce distinct toxic responses in earthworms (Eisenia fetida). Here, we used proteomics techniques to compare the responses of E. fetida to exposure to the 10% lethal concentration (14d-LC10) of benzo[a]pyrene (BaP) or cadmium (Cd) in natural red soil (China). BaP exposure markedly induced the expression of oxidation-reduction proteins, whereas Cd exposure mainly induced the expression of proteins involved in transcription- and translation-related processes. Furthermore, calmodulin-binding proteins were differentially expressed upon exposure to different pollutants...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28405479/comparison-of-biofilm-formation-capacities-of-two-clinical-isolates-of-staphylococcus-epidermidis-with-and-without-icaa-and-icad-genes-on-intraocular-lenses
#10
Sertaç Argun Kıvanç, Merih Kıvanç, Volkan Kılıç, Gülay Güllülü, Ahmet Tuncer Özmen
OBJECTIVES: To compare biofilm formations of two Staphylococcus epidermidis (S. epidermidis) isolates with known biofilm formation capacities on four different intraocular lenses (IOL) that have not been studied before. MATERIALS AND METHODS: Two isolates obtained from ocular surfaces and identified in previous studies and stored at -86 °C in 15% glycerol in the microbiology laboratory of the Anadolu University Department of Biology were purified and used in the study...
April 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28405246/modulation-of-benzo-a-pyrene-dna-adduct-formation-by-cyp1-inducer-and-inhibitor
#11
REVIEW
Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA adducts. This enzyme is strongly induced by many different chemical agents, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which binds to the aryl hydrocarbon receptor (AhR). Therefore, AhR activators are suspected to have the potential to aggravate the toxicity of BaP through the induction of CYP1A1...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28401464/efficient-regeneration-and-improved-sonication-assisted-agrobacterium-transformation-saat-method-for-catharanthus-roseus
#12
Pravej Alam, Zainul Abdeen Khan, Malik Zainul Abdin, Jawaid A Khan, Parvaiz Ahmad, Shereen F Elkholy, Mahmoud A Sharaf-Eldin
Catharanthus roseus is an important medicinal plant known for its pharmacological qualities such as antimicrobial, anticancerous, antifeedant, antisterility, antidiabetic activities. More than 130 bioactive compounds like vinblastine, vindoline and vincristine have been synthesized in this plant. Extensive studies have been carried out for optimization regeneration and transformation protocols. Most of the protocol described are laborious and time-consuming. Due to sophisticated protocol of regeneration and genetic transformation, the production of these bioactive molecules is less and not feasible to be commercialized worldwide...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28401460/enhanced-production-of-berberine-in-in-vitro-regenerated-cell-of-tinospora-cordifolia-and-its-analysis-through-lcms-qtof
#13
Jitendra Mittal, Madan Mohan Sharma
Tinospora cordifolia is a prioritized medicinal plant and having an immense medicinal importance especially in Indian medicinal system. But this plant needs a regeneration protocol for its rapid propagation. An efficient regeneration protocol was developed for T. cordifolia using nodal explants. High frequency of multiple shoot formation was induced when the nodal segments were cultured on MS medium supplemented with BAP (1.0 mg L(-1)) and 2-iP (0.5 mg L(-1)). The highest mean number of shoots per nodal explant (7...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28373284/pathogenic-acinetobacter-species-have-a-functional-type-i-secretion-system-and-contact-dependent-inhibition-systems
#14
Christian M Harding, Marina R Pulido, Gisela Di Venanzio, Rachel L Kinsella, Andrew I Webb, Nichollas E Scott, Jerónimo Pachón, Mario F Feldman
Pathogenic Acinetobacter species, including A. baumannii and A. nosocomialis, are opportunistic human pathogens of increasing relevance worldwide. Although their mechanisms of drug resistance are well studied, the virulence factors that govern Acinetobacter pathogenesis are incompletely characterized. Here we define the complete secretome of A. nosocomialis strain M2 in minimal media and demonstrate that pathogenic Acinetobacter species produce both a functional type I secretion system (T1SS) and a contact dependent inhibition (CDI) system...
April 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28369060/the-zic-family-homologue-odd-paired-regulates-alk-expression-in-drosophila
#15
Patricia Mendoza-García, Fredrik Hugosson, Mahsa Fallah, Michael L Higgins, Yasuno Iwasaki, Kathrin Pfeifer, Georg Wolfstetter, Gaurav Varshney, Dmitry Popichenko, J Peter Gergen, Korneel Hens, Bart Deplancke, Ruth H Palmer
The Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) plays a critical role in the specification of founder cells (FCs) in the Drosophila visceral mesoderm (VM) during embryogenesis. Reporter gene and CRISPR/Cas9 deletion analysis reveals enhancer regions in and upstream of the Alk locus that influence tissue-specific expression in the amnioserosa (AS), the VM and the epidermis. By performing high throughput yeast one-hybrid screens (Y1H) with a library of Drosophila transcription factors (TFs) we identify Odd-paired (Opa), the Drosophila homologue of the vertebrate Zic family of TFs, as a novel regulator of embryonic Alk expression...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28364205/spatial-distribution-of-atmospheric-pahs-and-their-genotoxicity-in-petrochemical-industrialized-lanzhou-valley-northwest-china
#16
Li Wang, Yuan Zhao, Xin Yi, Zhanxiang Wang, Yayi Yi, Tao Huang, Hong Gao, Jianmin Ma
The present study investigated the spatial and seasonal variations and sources of 16 priority polycyclic aromatic hydrocarbons (PAHs) in Lanzhou, a petrochemical industrialized and the capital city of Gansu province, northwest China. The human health risks to these PAHs were assessed using an in vitro genotoxic bioassay technique. Associations among direct genotoxic potency, atmospheric PAH concentrations, and potential carcinogen risks were examined. Due to high PAH emissions from fossil fuel combustion and petrochemical industries, considerable higher PAH levels in the atmosphere were observed in Xigu district, a suburb featured by heavy petrochemical industry, compared with those collected at downtown and rural sampling sites...
March 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28363852/understanding-the-role-of-3-o-acetyl-11-keto-%C3%AE-boswellic-acid-in-conditions-of-oxidative-stress-mediated-hepatic-dysfunction-during-benzo-a-pyrene-induced-toxicity
#17
Manoj Kumar, Gurpreet Singh, Preeti Bhardwaj, Sunil Kumar Dhatwalia, D K Dhawan
The present study was planned to see whether 3-O-Acetyl-11- keto-β-boswellic acid has any protective effects against benzo(a)pyrene (BaP) induced toxicity or not. In vitro studies show concentration dependent linear association of radical scavenging activity of AK which is comparable to ascorbic acid taken as reference compound. For in vivo studies, the animals were divided randomly into five groups which included a) normal control, b) vehicle treated (olive oil), c) BaP treated, d) AK treated and e) AK + BaP (combined treated)...
March 28, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28359976/-trim36-hypermethylation-is-involved-in-polycyclic-aromatic-hydrocarbons-induced-cell-transformation
#18
Zhini He, Daochuan Li, Junxiang Ma, Liping Chen, Huawei Duan, Bo Zhang, Chen Gao, Jie Li, Xiumei Xing, Jian Zhao, Shan Wang, Fangping Wang, Haiyan Zhang, Huiyao Li, Shen Chen, Xiaowen Zeng, Qing Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen
Long term exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with the increasing risk of lung cancer. To identify differentially hypermethylated genes associated with PAHs-induced carcinogenicity, we performed genome-wide DNA methylation analysis in 20 μM benzo(a)pyrene (BaP)-transformed human bronchial epithelial (HBE) cells at different stages of cell transformation. Several methylated genes (CNGA4, FLT1, GAREM1, SFMBT2, TRIM36) were differentially hypermethylated and their mRNA was suppressed in cells at both pre-transformed and transformed stages...
March 27, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28359898/chitosan-mediated-enhancement-of-hydrolysable-tannin-in-phyllanthus-debilis-klein-ex-willd-via-plant-cell-suspension-culture
#19
Malayaman V, Sisubalan N, Senthilkumar R P, Sheik Mohamed S, Ranjithkumar R, Ghouse Basha M
Phyllanthus debilis Klein ex Willd. is wild medicinal plant used in the traditional system of medicine. This plant has been actively used for hepatoprotection and to cure many diseases including jaundice and so on; which leads to complete extinction of this particular species. Therefore, the chitosan mediated cost effective cell suspension method has been developed for the production of hydrolysable tannin. The hydrolysable tannins are the main therapeutically active constituents with antioxidant, anticancer, and antimicrobial properties...
March 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28356998/polycyclic-aromatic-hydrocarbons-bound-to-outdoor-and-indoor-airborne-particles-pm2-5-and-their-mutagenicity-and-carcinogenicity-in-silesian-kindergartens-poland
#20
Ewa Błaszczyk, Wioletta Rogula-Kozłowska, Krzysztof Klejnowski, Izabela Fulara, Danuta Mielżyńska-Švach
Assessment of exposure to polycyclic aromatic hydrocarbons (PAHs) is important due to the widespread presence of PAHs in the environment and their toxicological relevance, especially to susceptible populations such as children and their health. The aim of this study is to compare indoor and outdoor concentrations of particulate matter with a diameter of 2.5 μm or less (PM2.5) and 15 individual PAHs, as well as contribution of the analyzed PAHs to mutagenic and carcinogenic activity. Samples were collected during spring season in two sites in southern Poland (Silesia) representing urban and rural areas...
2017: Air Quality, Atmosphere, & Health
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