keyword
MENU ▼
Read by QxMD icon Read
search

BAP

keyword
https://www.readbyqxmd.com/read/29331918/dna-damage-in-marine-rock-oyster-saccostrea-cucullata-exposed-to-environmentally-available-pahs-and-heavy-metals-along-the-arabian-sea-coast
#1
Subhodeep Sarker, Deepti Vashistha, Munmun Saha Sarker, A Sarkar
Molecular biomarkers are used world wide for quick assessment of the immediate effect of environmental pollution on marine ecosystems. Recently, we evaluated oxidative stress responses of marine rock oyster, Saccostrea cucullata impacted due to polycyclic aromatic hydrocarbons (PAHs) accumulated in their tissues at a few sampling sites along the coast of Goa around the region of the Arabian sea coast, India (Sarkar et al., 2017). Using a combination of partial alkaline unwinding and comet assays, we now report a comprehensive study on the impairment of DNA integrity (DI) in S...
January 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29323757/differentiation-associated-urothelial-cytochrome-p450-oxidoreductase-predicates-the-xenobiotic-metabolising-activity-of-luminal-muscle-invasive-bladder-cancers
#2
Simon C Baker, Volker M Arlt, Radek Indra, Madeleine Joel, Marie Stiborova, Ian Eardley, Niaz Ahmad, Wolfgang Otto, Maximilian Burger, Peter Rubenwolf, David H Phillips, Jennifer Southgate
Extra-hepatic metabolism of xenobiotics by epithelial tissues has evolved as a self-defence mechanism but has potential to contribute to the local activation of carcinogens. Bladder epithelium (urothelium) is bathed in excreted urinary toxicants and pro-carcinogens. This study reveals how differentiation affects cytochrome P450 (CYP) activity and the role of NADPH:P450 oxidoreductase (POR). CYP1A1 and CYP1B1 transcripts were inducible in normal human urothelial (NHU) cells maintained in both undifferentiated and functional barrier-forming differentiated states in vitro...
January 11, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29323281/bap-sil1-regulates-the-molecular-chaperone-bip-by-coupling-release-of-nucleotide-and-substrate
#3
Mathias Rosam, Daniela Krader, Christina Nickels, Janine Hochmair, Katrin C Back, Ganesh Agam, Anders Barth, Cathleen Zeymer, Jelle Hendrix, Markus Schneider, Iris Antes, Jochen Reinstein, Don C Lamb, Johannes Buchner
BiP is the endoplasmic member of the Hsp70 family. BiP is regulated by several co-chaperones including the nucleotide-exchange factor (NEF) Bap (Sil1 in yeast). Bap is a two-domain protein. The interaction of the Bap C-terminal domain with the BiP ATPase domain is sufficient for its weak NEF activity. However, stimulation of the BiP ATPase activity requires full-length Bap, suggesting a complex interplay of these two factors. Here, single-molecule FRET experiments with mammalian proteins reveal that Bap affects the conformation of both BiP domains, including the lid subdomain, which is important for substrate binding...
January 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29320557/high-ahr-expression-in-breast-tumors-correlates-with-expression-of-genes-from-several-signaling-pathways-namely-inflammation-and-endogenous-tryptophan-metabolism
#4
Sophie Vacher, Patrice Castagnet, Walid Chemlali, François Lallemand, Didier Meseure, Marc Pocard, Ivan Bieche, Martine Perrot-Applanat
Increasing epidemiological and animal experimental data provide substantial support for the role of aryl hydrocarbon receptor (AhR) in mammary tumorigenesis. The effects of AhR have been clearly demonstrated in rodent models of breast carcinogenesis and in several established human breast cancer cell lines following exposure to AhR ligands or AhR overexpression. However, relatively little is known about the role of AhR in human breast cancers. AhR has always been considered to be a regulator of toxic and carcinogenic responses to environmental contaminants such as TCDD (dioxin) and benzo[a]pyrene (BaP)...
2018: PloS One
https://www.readbyqxmd.com/read/29317959/impact-of-oxidative-stress-and-newer-antiepileptic-drugs-on-the-albumin-and-cortisol-value-in-severe-motor-and-intellectual-disabilities-with-epilepsy
#5
Masahito Morimoto, Toshiaki Hashimoto, Taisuke Kitaoka, Shojiro Kyotani
Background: Epilepsy is a common complication in patients with severe motor and intellectual disabilities (SMID). There are no reports as yet of the effects of these medications in vivo other than their epileptic efficacy. The purpose of this study was to clarify the effects of the newer antiepileptic drugs (AEDs) on the blood biochemical parameters and oxidative stress in SMID with epilepsy by comparing the therapeutic effects between a group of patients receiving lamotrigine (LTG) and levetiracetam (LEV) in addition to the conventional AEDs (newer AED group) and a group receiving conventional AEDs alone (old AED group)...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29317668/hygroscopic-coating-of-sulfuric-acid-shields-oxidant-attack-on-the-atmospheric-pollutant-benzo-a-pyrene-bound-to-model-soot-particles
#6
Debajyoti Ray, Tara Shankar Bhattacharya, Abhijit Chatterjee, Achintya Singha, Sanjay K Ghosh, Sibaji Raha
Substantial impacts on climate have been documented for soot‒sulfuric acid (H2SO4) interactions in terms of optical and hygroscopic properties of soot aerosols. However, the influence of H2SO4 on heterogeneous chemistry on soot remains unexplored. Additionally, oxidation rate coefficients for polycyclic aromatic hydrocarbons intrinsic to the atmospheric particles evaluated in laboratory experiments seem to overestimate their degradation in ambient atmosphere, possibly due to matrix effects which are hitherto not mimicked in laboratory experiments...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316066/smarcb1-ini1-baf47-deficient-pleural-malignant-mesothelioma-with-rhabdoid-features
#7
Noriko Kimura, Masaru Hasegawa, Kenzo Hiroshima
Malignant mesothelioma (MM) with rhabdoid features is an MM variant. Fifteen cases have been reported previously, all of which were combined with other types of MM. Herein, we report an autopsy case of pleural MM with monomorphic rhabdoid features. The patient was a 62-year-old male without a history of asbestos exposure. An autopsy revealed a soft, granular tumor that replaced the entire left pleura and had invaded to the diaphragm and lower lobe of the lung. The tumor cells, which had eosinophilic plump cytoplasm and eccentric nuclei, were loosely cohesive...
January 5, 2018: Pathology International
https://www.readbyqxmd.com/read/29315775/expression-of-aryl-hydrocarbon-receptor-regulated-genes-and-superoxide-dismutase-in-the-antarctic-eelpout-pachycara-brachycephalum-exposed-to-benzo-a-pyrene
#8
Anneli Strobel, Felix C Mark, Helmut Segner, Patricia Burkhardt-Holm
The aryl hydrocarbon receptor (AHR) pathway mediates many, if not all, responses of fish to dioxin-like compounds. The Southern Ocean is progressively exposed to increasing concentrations of anthropogenic pollutants. Antarctic fish are known to accumulate those pollutants, yet nothing is known about their capability to induce chemical biotransformation via the AHR pathway. The objective of this study was to investigate if Antarctic eelpout, Pachycara brachycephalum, respond to anthropogenic pollutants by activation of the AHR and its target gene cytochrome P4501A (CYP1A), and of superoxide dismutase (SOD) which served as a representative for oxidative stress...
January 5, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29314254/manual-versus-automated-streaking-system-in-clinical-microbiology-laboratory-performance-evaluation-of-previ-isola-for-blood-culture-and-body-fluid-samples
#9
Qute Choi, Hyun Jin Kim, Jong Wan Kim, Gye Cheol Kwon, Sun Hoe Koo
BACKGROUND: The process of plate streaking has been automated to improve routine workflow of clinical microbiology laboratories. Although there were many evaluation reports about the inoculation of various body fluid samples, few evaluations have been reported for blood. In this study, we evaluated the performance of automated inoculating system, Previ Isola for various routine clinical samples including blood. METHODS: Blood culture, body fluid, and urine samples were collected...
January 4, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29311711/association-of-bap-with-urinary-albumin-excretion-in-postmenopausal-but-not-premenopausal-non-ckd-japanese-women
#10
Etsuko Ozaki, Shinsuke Yamada, Nagato Kuriyama, Daisuke Matsui, Isao Watanabe, Teruhide Koyama, Yasuo Imanishi, Masaaki Inaba, Yoshiyuki Watanabe
We investigated whether the phosphate (Pi) load in the circulation causes renal damage in non-CKD women. This cross-sectional study included 1,094 non-CKD Japanese women. Fibroblast growth factor (FGF)-23 as a parameter for the Pi load, bone alkaline phosphatase (BAP) as a bone metabolic marker, and the urinary albumin-to-creatinine ratio (UACR) as an early marker for renal damage were measured. Postmenopausal women exhibited significantly higher levels of serum Pi, FGF-23, BAP, and UACR and significantly lower eGFR than premenopausal women...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305406/early-population-based-outcomes-of-infants-born-with-congenital-diaphragmatic-hernia
#11
Anna-May Long, Kathryn J Bunch, Marian Knight, Jennifer J Kurinczuk, Paul D Losty
PURPOSE: This study aims to describe short-term outcomes of live-born infants with congenital diaphragmatic hernia (CDH) and to identify prognostic factors associated with early mortality. DESIGN: A prospective population cohort study was undertaken between April 2009 and September 2010, collecting data on live-born infants with CDH from all 28 paediatric surgical centres in the UK and Ireland using an established surgical surveillance system. Management and outcomes are described...
January 4, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29290007/bone-geometry-quality-and-bone-markers-in-children-with-type-1-diabetes-mellitus
#12
Roberto Franceschi, Silvia Longhi, Vittoria Cauvin, Angelo Fassio, Giuseppe Gallo, Fiorenzo Lupi, Petra Reinstadler, Antonio Fanolla, Davide Gatti, Giorgio Radetti
Adults with Type 1 diabetes mellitus show a high risk of bone fracture, probably as a consequence of a decreased bone mass and microarchitectural bone alterations. The aim of the study was to investigate the potential negative effects of type 1 diabetes on bone geometry, quality, and bone markers in a group of children and adolescents. 96 children, mean age 10.5 ± 3.1 years, agreed to participate to the study. Bone geometry was evaluated on digitalized X-rays at the level of the 2nd metacarpal bone. The following parameters were investigated and expressed as SDS: outer diameter (D), inner diameter (d), cortical area (CA), and medullary area (MA)...
December 30, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29288391/the-levels-and-potential-carcinogenic-risks-of-pahs-in-liaohe-estuarine-reed-wetland-soils
#13
Yinhai Lang, Huaxuan Zhao, Ben Liu, Chunmiao Zhu
Sixteen polycyclic aromatic hydrocarbons (PAHs) were quantified by GC/MS in 30 soil samples of Liaohe estuarine reed wetland. The total concentrations of 16 PAHs ranged from 235 to 374 ng g-1, and seven carcinogenic PAHs concentrations were in the range of 83-109 ng g-1. A probabilistic carcinogenic potential for three age groups (including children, teenagers, and adults) exposed to soil PAHs via three pathways was quantitatively calculated based on Monte Carlo simulations. The 95th percentiles carcinogenic risks of PAHs for children, teenagers, and adults were 7...
December 29, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29287444/polycyclic-aromatic-hydrocarbons-content-and-fatty-acids-profile-in-coconut-safflower-evening-primrose-and-linseed-oils
#14
Simone Alves da Silva, Elizabeth A F da Silva Torres, Adriana Palma de Almeida, Geni Rodrigues Sampaio
This study aimed at evaluating the polycyclic aromatic hydrocarbons (PAHs) contamination of commercial vegetable oils and examined the identity through the fatty acids profiles. Coconut, safflower, evening primrose, and linseed oils marketed in São Paulo (Brazil) were investigated totaling 69 samples. Four PAHs, benzo[a]anthracene (BaA), chrysene (Chr), benzo[b]fluoranthene (BbF), and benzo[a]pyrene (BaP), were detected in 96% of the samples at individual levels ranging from not detected to 14.99 μg kg-1...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29282584/psychometric-properties-of-the-spanish-version-of-the-broad-autism-phenotype-questionnaire-strengths-weaknesses-and-future-improvements
#15
Marta Godoy-Giménez, Antonio González-Rodríguez, Fernando Cañadas, Angeles F Estévez, Pablo Sayans-Jiménez
The Broad autism phenotype (BAP) refers to a set of subclinical behavioural characteristics qualitatively similar to those presented in Autism spectrum disorders (ASDs). The BAP questionnaire (BAPQ) has been widely used to assess the BAP both in relatives of ASD people and within the general population. The current study presents the first Spanish version of the BAPQ (BAPQ-SP) and analyses its psychometric properties, including validity evidences based on the BAPQ scores relationship with other variables. Our results only support the use of the Aloof and Rigid sub-scales to assess this phenotype, whereas Pragmatic Language sub-scale seems to be the main source of misfit...
December 27, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29282103/within-host-evolution-of-enterococcus-faecium-during-longitudinal-carriage-and-transition-to-bloodstream-infection-in-immunocompromised-patients
#16
Danesh Moradigaravand, Theodore Gouliouris, Beth Blane, Plamena Naydenova, Catherine Ludden, Charles Crawley, Nicholas M Brown, M Estée Török, Julian Parkhill, Sharon J Peacock
BACKGROUND: Enterococcus faecium is a leading cause of hospital-acquired infection, particularly in the immunocompromised. Here, we use whole genome sequencing of E. faecium to study within-host evolution and the transition from gut carriage to invasive disease. METHODS: We isolated and sequenced 180 E. faecium from four immunocompromised patients who developed bloodstream infection during longitudinal surveillance of E. faecium in stool and their immediate environment...
December 27, 2017: Genome Medicine
https://www.readbyqxmd.com/read/29276542/different-training-responses-to-eccentric-endurance-exercise-at-low-and-moderate-altitudes-in-pre-diabetic-men-a-pilot-study
#17
Kultida Klarod, Marc Philippe, Hannes Gatterer, Martin Burtscher
This pilot study aimed (a) to evaluate the effects of eccentric exercise training at low and moderate altitudes on physical fitness in pre-diabetic men and (b) to establish whether or not oxidative stress levels and antioxidant status were associated with performance improvements. In this crossover trial, five pre-diabetic men conducted nine downhill walking sessions (3 days/week, 3 consecutive weeks) at low altitude (from 1360 to 850 m) and one year later at moderate altitude (from 2447 to 2000 m). Exercise testing and the determination of parameters of oxidative stress and antioxidant capacity were performed pre- and post-training...
2017: Sport Sciences for Health
https://www.readbyqxmd.com/read/29251033/significant-improvement-of-bone-mineral-density-by-denosumab-without-bisphosphonate-pre-treatment-in-glucocorticoid-induced-osteoporosis
#18
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
Objective The aim of this study was to evaluate differences in outcomes of denosumab for a year with or without bisphosphonate (BP) pre-treatment in patients with glucocorticoid-induced osteoporosis (GIO). Methods Forty-eight female patients with GIO with low bone mineral density (T score of BMD; less than -3.0SD) were retrospectively enrolled and classified into the following 2 groups: 1) GIO with BP pre-treatment (BP pre-treated group; n = 24) and 2) GIO without BP treatment (BP pre-untreated group; n = 24)...
December 18, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29248969/somatic-embryogenesis-of-muskmelon-cucumis-melo-l-and-genetic-stability-assessment-of-regenerants-using-flow-cytometry-and-issr-markers
#19
Mohammad Reza Raji, Mahmoud Lotfi, Masoud Tohidfar, Bahman Zahedi, Angela Carra, Loredana Abbate, Francesco Carimi
A new protocol for in vitro regeneration through direct somatic embryogenesis for two muskmelon cultivars (Cucumis melo L., "Mashhadi" and "Eivanaki") is reported. Somatic embryos were obtained culturing 4- and 8-day-old cotyledons, seeds, and hypocotyls on Murashige and Skoog medium supplemented with three different hormonal combinations never tested so far for melon (naphthoxyacetic acid (NOA) + thidiazuron (TDZ), NOA + 6-banzylaminopurine (BAP), and 2,4-dichlorophenoxyacetic acid (2,4-D) + N-(2-chloro-4-pyridyl)-N'-phenylurea (4-CPPU))...
December 17, 2017: Protoplasma
https://www.readbyqxmd.com/read/29245133/source-identification-and-ecological-impact-evaluation-of-pahs-in-urban-river-sediments-a-case-study-in-taiwan
#20
Y T Tu, J H Ou, D C W Tsang, C D Dong, C W Chen, C M Kao
The Love River and Ho-Jin River, two major urban rivers in Kaohsiung City, Taiwan, are moderately to heavily polluted because different types of improperly treated wastewaters are discharged into the rivers. In this study, sediment and river water samples were collected from two rivers to investigate the river water quality and accumulation of polycyclic aromatic hydrocarbons (PAHs) in sediments. The spatial distribution, composition, and source appointment of PAHs of the sediments were examined. The impacts of PAHs on ecological system were assessed using toxic equivalence quotient (TEQ) of potentially carcinogenic PAHs (TEQcarc) and sediment quality guidelines...
December 5, 2017: Chemosphere
keyword
keyword
72733
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"