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https://www.readbyqxmd.com/read/29348072/structure-based-development-of-an-osteoprotegerin-like-glycopeptide-that-blocks-rankl-rank-interactions-and-reduces-ovariectomy-induced-bone-loss-in-mice
#1
Chao Liu, Xiao Chen, Xin Zhi, Weizong Weng, Quan Li, Xiang Li, Yan Zou, Jiacan Su, Hong-Gang Hu
Osteoporosis is a metabolic bone disease characterized by low bone mass and micro-architectural deterioration of bone, for which the underlying mechanism is an imbalance between bone resorption and bone remodeling. The protein-protein interactions between receptor activator of nuclear factor-κB ligand (RANKL), RANK (its receptor), and osteoprotegerin (OPG), are known to mediate the development and activation of osteoclasts in bone remodeling, and are regarded as a pivotal therapeutic target for the treatment of osteoporosis...
January 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29343527/visual-outcomes-after-chemotherapy-for-optic-pathway-glioma-in-children-with-and-without-neurofibromatosis-type-1-results-of-the-international-society-of-paediatric-oncology-siop-low-grade-glioma-2004-trial-uk-cohort
#2
Kevin Falzon, Evangelos Drimtzias, Susan Picton, Ian Simmons
AIMS: To report visual acuity (VA) outcomes following chemotherapy for optic pathway glioma (OPG) in children with or without neurofibromatosis type-1 (NF1) and to analyse associated risk factors. METHODS: A prospective, multicentre, cohort study involving 155 children treated between September 2004 and December 2012. Initial and final VA was used for per-eye and per-subject analysis. Correlation tests were performed to determine whether initial VA predicted final VA...
January 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29336616/study-of-the-osteoprotegerin-receptor-activator-of-nuclear-factor-kb-ligand-system-association-with-inflammation-and-atherosclerosis-in-systemic-sclerosis
#3
Rania M Gamal, Walid M Gamal, Abeer M Ghandour, Hanan Sayed M Abozaid, Mona Embarek Mohamed, Yasser Emad, Ahmed Abdel Galeel
OBJECTIVE: we aimed to study systemic sclerosis patients in order to assess osteoprotegerin/Receptor activator of nuclear factor-kB ligand (OPG/RANKL) system and find the relation of these biomarkers with the clinical features of the disease, the carotid intima thickness, markers of inflammation, lipid profile, and other laboratory characteristics. METHODS: both the level of (RANKL), (OPG) in sera of participants, in 30 (SSc) patients and the atherosclerotic changes affecting the common carotid artery were measured and, were compared to 30 healthy controls matched for age and sex...
January 16, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29333371/use-of-repeat-anterior-maxillary-distraction-to-correct-residual-midface-hypoplasia-in-cleft-patients
#4
Sunil Richardson, Shreya Krishna, Avi Bansal
Objectives: The study was designed to evaluate the efficacy of performing a second, repeat anterior maxillary distraction (AMD) to treat residual cleft maxillary hypoplasia. Materials and Methods: Five patients between the ages of 12 to 15 years with a history of AMD and with residual cleft maxillary hypoplasia were included in the study. Inclusion was irrespective of gender, type of cleft lip and palate, and the amount of advancement needed. Repeat AMD was executed in these patients 4 to 5 years after the primary AMD procedure to correct the cleft maxillary hypoplasia that had developed since the initial procedure...
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29330911/title-prognostic-significance-of-arterial-stiffness-and-osteoprotegerin-in-patients-with-stable-coronary-artery-disease
#5
Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Maniatis, Georgios Georgiopoulos, Eleni Kokkou, Vasiliki Tsigkou, Marina Zaromitidou, Alexis Antonopoulos, Manolis Vavuranakis, Christodoulos Stefanadis, Athanasios G Papavassiliou, Dimitris Tousoulis
BACKGROUND: Arterial stiffness and vascular calcification significantly contribute to coronary atherosclerosis progression. The prognostic value of increased arterial stiffness and vascular calcification in subjects with stable coronary artery disease (CAD) after percutaneous coronary intervention(PCI) is currently under question. MATERIALS AND METHODS: We randomly enrolled 262 patients with stable CAD one month after successful PCI. Carotid femoral pulse wave velocity (PWV) was measured as a well-established index of central aortic stiffness...
January 13, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29330573/tocotrienol-supplementation-suppressed-bone-resorption-and-oxidative-stress-in-postmenopausal-osteopenic-women-a-12-week-randomized-double-blinded-placebo-controlled-trial
#6
C-L Shen, S Yang, M D Tomison, A W Romero, C K Felton, H Mo
Tocotrienols have shown bone-protective effect in animals. This study showed that a 12-week tocotrienol supplementation decreased concentrations of bone resorption biomarker and bone remodeling regulators via suppressing oxidative stress in postmenopausal osteopenic women. INTRODUCTION: Tocotrienols (TT) have been shown to benefit bone health in ovariectomized animals, a model of postmenopausal women. The purpose of this study was to evaluate the effect of 12-week TT supplementation on bone markers (serum bone-specific alkaline phosphatase (BALP), urine N-terminal telopeptide (NTX), serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), and serum osteoprotegerin (OPG)), urine calcium, and an oxidative stress biomarker (8-hydroxy-2'-deoxyguanosine (8-OHdG)) in postmenopausal women with osteopenia...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29330358/pathogenesis-of-bone-disease-in-multiple-myeloma-from-bench-to-bedside
#7
REVIEW
Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Meletios A Dimopoulos
Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality of life of myeloma patients, and it affects dramatically their morbidity and mortality. The basis of the pathogenesis of myeloma-related bone disease is the uncoupling of the bone-remodeling process. The interaction between myeloma cells and the bone microenvironment ultimately leads to the activation of osteoclasts and suppression of osteoblasts, resulting in bone loss. Several intracellular and intercellular signaling cascades, including RANK/RANKL/OPG, Notch, Wnt, and numerous chemokines and interleukins are implicated in this complex process...
January 12, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29328414/malat1-enhanced-the-proliferation-of-human-osteoblasts-treated-with-ultra%C3%A2-high-molecular-weight-polyethylene-by-targeting-vegf-via-mir%C3%A2-22%C3%A2-5p
#8
Xucheng Yang, Yingying Zhang, Yusheng Li, Ting Wen
Osteolysis associated with an implanted prosthesis is the major cause of failure in prosthesis implantation, and a severe public health issue worldwide. The type of bone metabolism associated with this disorder has been a major focus for improving the outcomes of patients with osteolysis. The role of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1; a member of the long coding RNA family) during the onset of osteolysis and the related molecular regulatory mechanism in ultra‑high molecular weight polyethylene (UHMWPE)‑treated hFOB 1...
January 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29325759/snps-in-the-vicinity-of-p2x7r-rank-rankl-opg-and-wnt-signalling-pathways-and-their-association-with-bone-phenotypes-in-academy-footballers
#9
Ian Varley, David C Hughes, Julie P Greeves, William D Fraser, Craig Sale
CONTEXT: Genotype plays an important role in influencing bone phenotypes, such as bone mineral density, but the role of genotype in determining responses of bone to exercise has yet to be elucidated. OBJECTIVE: To determine whether 10 SNPs associated with genes in the vicinity of P2X7R, RANK/RANKL/OPG and Wnt Signalling Pathways are associated with bone phenotypes in elite academy footballers (Soccer players) and to determine whether these genotypes are associated with training induced changes in bone...
January 8, 2018: Bone
https://www.readbyqxmd.com/read/29323724/autoregulation-of-rank-ligand-in-oral-squamous-cell-carcinoma-tumor-cells
#10
Yuvaraj Sambandam, Purushoth Ethiraj, Jessica Hathway-Schrader, Chad Novince, Ezhil Panneerselvam, Kumaran Sundaram, Sakamuri V Reddy
Oral squamous cell carcinoma (OSCC) is the most common malignancy among oral cancers and shows potent activity for local bone invasion. Receptor activator of nuclear factor κB (RANK) ligand (RANKL) is critical for bone-resorbing osteoclast formation. We previously demonstrated that OSCC tumor cells express high levels of RANKL. In this study, confocal microscopy demonstrated RANKL specific receptor, RANK expression in OSCC tumor cell lines (SCC1, SCC12 and SCC14a). We also confirmed the expression of RANK and RANKL in primary human OSCC tumor specimens...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29317302/bu-shen-tong-luo-decoction-prevents-bone-loss-via-inhibition-of-bone-resorption-and-enhancement-of-angiogenesis-in-ovariectomy-induced-osteoporosis-of-rats
#11
Han Yuan, Linyan Xiao, Wen Min, Wenchao Yuan, Shengfeng Lu, Guicheng Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Gathering three ancient formulas, traditional Chinese medicine Bu-Shen-Tong-Luo decoction (BSTLD) has been used to treat postmenopausal osteoporosis (PMO) at the Jiangsu Province Hospital of Chinese Medicine for decades. However, the effect of BSTLD on angiogenesis and bone resorption as well as its possible mechanism are still unknown. AIM OF THE STUDY: This study was aimed to evaluate the preventive effect of BSTLD on ovariectomy-induced bone loss and vasculature disorder, and to investigate the possible bone protection mechanism of BSTLD in inhibiting bone resorption by enhancing angiogenesis signaling in ovariectomy-induced osteoporosis of rats...
January 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29316231/osteogenic-cellular-activity-around-onlaid-octacalcium-phosphate-gelatin-composite-onto-rat-calvaria
#12
Ryosuke Iwama, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
The activity and the distribution of osteogenic cells around octacalcium phosphate (OCP) granules combined with gelatin matrix (OCP/Gel) onlaid on rat calvaria were analyzed histomorphometrically and immunohistochemically during vertical bone augmentation under mechanical or non-mechanical environment until 8 weeks. OCP/Gel disk was placed in subperiosteal pocket on the calvaria with or without polytetrafluoroethylene (PTFE) support. The latter is a non-mechanical stress model to alleviate the mechanical stress from the subcutaneous tissues...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29315650/levels-of-oxidative-stress-biomarkers-and-bone-resorption-regulators-in-apical-periodontitis-lesions-infected-by-epstein-barr-virus
#13
A Jakovljevic, M Andric, N Nikolic, V Coric, S Krezovic, J Carkic, A Knezevic, K Beljic-Ivanovic, M Plješa-Ercegovac, M Miletić, I Soldatovic, T Radosavljevic, T Jovanovic, T Simic, V Ivanovic, J Milasin
AIM: To investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers (8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)) and bone resorption regulators (receptor activator of nuclear factor (NF-κB) ligand (RANKL) and osteoprotegerin (OPG)) compared to EBV negative periapical lesions and healthy pulp tissues. METHODOLOGY: The experimental group consisted of 30 EBV positive and 30 EBV negative periapical lesions collected in conjunction with apicoectomy...
January 9, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29313442/osteoprotegerin-concentration-is-associated-with-the-presence-and-severity-of-peripheral-arterial-disease-in-type-2-diabetes-mellitus
#14
Katarína Demková, Miriam Kozárová, Zuzana Malachovská, Martin Javorský, Ivan Tkáč
BACKGROUND: Osteoprotegerin plays a role in the development of several bone diseases. In addition, osteoprotegerin may contribute to the development of vascular disease. Little is known about the association between serum osteoprotegerin levels and the presence or severity of peripheral arterial disease (PAD). The aim of this study was to examine the association between serum osteoprotegerin levels and both the presence as well as the severity of lower extremity arterial disease in patients with type 2 diabetes (T2DM)...
January 9, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29310535/associations-of-osteoprotegerin-with-coronary-artery-calcification-among-women-with-systemic-lupus-erythematosus-and-healthy-controls
#15
I G Poornima, K Shields, L H Kuller, S M Manzi, R Ramsey-Goldman, C Richardson, E Rhew, D D Dunlop, J Song, D Edmundowicz, G T Kondos, J J Carr, C B Langman, H Price, A H Chung, L B Santelices, R H Mackey
Objective We tested the hypothesis that higher circulating levels of osteoprotegerin (OPG) are related to higher levels of coronary artery calcification (CAC) among women with systemic lupus erythematosus (SLE) compared with healthy controls (HCs). Methods Among 611 women in two age- and race-matched SLE case-control studies, OPG was assayed in stored blood samples (HEARTS: plasma, n cases/controls = 122/124, and SOLVABLE: serum, n cases/controls = 185/180) and CAC was measured by electron beam computed tomography...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29303699/implication-of-osteoprotegerin-and-sclerostin-in-axial-spondyloarthritis-cardiovascular-disease-study-of-163-spanish-patients
#16
Fernanda Genre, Javier Rueda-Gotor, Sara Remuzgo-Martínez, Alfonso Corrales, Begoña Ubilla, Verónica Mijares, Carlos Fernández-Díaz, Virginia Portilla, Ricardo Blanco, José Luis Hernández, Javier Llorca, Raquel López-Mejías, Miguel Angel González-Gay
OBJECTIVES: Due to the high incidence of cardiovascular disease in axial spondyloarthritis (axSpA), the search of potential biomarkers that may help to identify patients with high cardiovascular risk is of main importance. Therefore, in this study we assessed the implication of osteoprotegerin (OPG) and sclerostin (SCL), two biomarkers associated with cardiovascular disease and bone metabolism, in the clinical spectrum and atherosclerotic disease of patients with axSpA. METHODS: OPG and SCL serum levels were determined in 163 axSpA Spanish patients (119 ankylosing spondylitis and 44 non-radiographic axSpA) and 63 healthy controls by enzyme-linked immunosorbent assay...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29297549/rank-rankl-opg-expression-in-rapid-maxillary-expansion
#17
Maya Fernanda Manfrin Arnez, Larissa Soares Nogueira Ribeiro, Gabriel Dessotti Barretto, Patrícia Maria Monteiro, Edilson Ervolino, Maria Bernadete Sasso Stuani
The aim of this study was to evaluate osteoclastogenesis signaling in midpalatal suture after rapid maxillary expansion (RME) in rats. Thirty male Wistar rats were randomly assigned to two groups with 15 animals each: control (C) and RME group. RME was performed by inserting a 1.5-mm-thick circular metal ring between the maxillary incisors. The animals were euthanized at 3, 7 and 10 days after RME. qRT-PCR was used to evaluate expression of Tnfsf11 (RANKL), Tnfrsf11a (RANK) and Tnfrsf11b (OPG). Data were submitted to statistical analysis using two-way ANOVA followed by Tukey test (a=0...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29297547/tlr2-signaling-pathway-in-alveolar-bone-osteogenesis-induced-by-aloe-vera-and-xenograft-xcb
#18
Utari Kresnoadi, Retno Pudji Rahayu, M Rubianto, Subijanto Marto Sudarmo, Hendrik Setia Budi
The aim of this study was to find the role of TLR2 signaling pathway in reducing osteoclast activity and promoting osteoblast growth by inducing a combination of Aloe vera and cancellous bovine xenograft (XCB) into dental extraction socket. Forty-eight Cavia cobayas were used. They were divided into eight groups (n=6). For control group, their mandibular incisors were extracted and filled with PEG. For treatment groups, they were extracted and filled with XCB, Aloe vera and the combination of Aloe vera and XCB...
May 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29296887/mesenchymal-stem-cells-expressing-osteoprotegerin-variants-inhibit-osteolysis-in-a-murine-model-of-multiple-myeloma
#19
Jerome T Higgs, Joo Hyoung Lee, Hong Wang, Vishnu C Ramani, Diptiman Chanda, Cherlene Y Hardy, Ralph D Sanderson, Selvarangan Ponnazhagan
The current treatment options for multiple myeloma (MM) osteolytic lesions are mainly combinations of chemotherapy and other small-molecule inhibitors, but toxic side effects still remain a major concern. Studies have shown that osteoclast activity is enhanced in MM patients through increased expression of receptor activator of nuclear factor κB ligand (RANKL), triggering RANK signaling on osteoclast precursors, which results in aggressive bone resorption. Furthermore, osteoprotegerin (OPG), a decoy receptor for RANKL, and the osteogenic potential of mesenchymal stem cells (MSCs) are significantly decreased in myeloma patients with multiple bone lesions...
November 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29288400/anti-inflammatory-and-antiresorptive-effects-of-calendula-officinalis-on-inflammatory-bone-loss-in-rats
#20
Joanna Trycia M Alexandre, Luzia Hermínia Teixeira Sousa, Mario Roberto Pontes Lisboa, Flávia A C Furlaneto, Danielle Rocha do Val, Mirna Marques, Hellíada C Vasconcelos, Iracema Matos de Melo, Renata Leitão, Gerly Anne Castro Brito, Paula Goes
OBJECTIVE: The aim of this work was to evaluate the anti-inflammatory and antiresorptive effects of Calendula officinalis (CLO) on alveolar bone loss (ABL) in rats. MATERIAL AND METHODS: Male Wistar rats were subjected to ABL by ligature with nylon thread around the second upper left molar. The contralateral hemimaxillae were used as control. Rats received saline solution (SAL) or CLO (10, 30, or 90 mg/kg) 30 min before ligature and daily until the 11th day. The maxillae were removed and prepared for macroscopic, radiographic, micro-tomographic, histopathologic, histometric analysis, and immunohistochemical localization of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG)...
December 29, 2017: Clinical Oral Investigations
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