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Topical Nitrates

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https://www.readbyqxmd.com/read/28097506/bioequivalence-methodologies-for-topical-drug-products-in-vitro-and-ex-vivo-studies-with-a-corticosteroid-and-an-anti-fungal-drug
#1
Leila Bastos Leal, Sarah F Cordery, M Begoña Delgado-Charro, Annette L Bunge, Richard H Guy
OBJECTIVE: To examine whether in vitro and ex vivo measurements of topical drug product performance correlate with in vivo outcomes, such that more efficient experimental approaches can be reliably and reproducibly used to establish (in)equivalence between formulations for skin application. MATERIALS AND METHODS: In vitro drug release through artificial membranes, and drug penetration into porcine skin ex vivo, were compared with published human in vivo studies...
January 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28086862/management-of-dentin-hypersensitivity-by-national-dental-practice-based-research-network-practitioners-results-from-a-questionnaire-administered-prior-to-initiation-of-a-clinical-study-on-this-topic
#2
Dorota T Kopycka-Kedzierawski, Cyril Meyerowitz, Mark S Litaker, Sidney Chonowski, Marc W Heft, Valeria V Gordan, Robin L Yardic, Theresa E Madden, Stephanie C Reyes, Gregg H Gilbert
BACKGROUND: Dentin hypersensitivity (DH) is a common problem encountered in clinical practice. The purpose of this study was to identify the management approaches for DH among United States dentists. METHODS: One hundred eighty five National Dental Practice-Based Research Network clinicians completed a questionnaire regarding their preferred methods to diagnose and manage DH in the practice setting, and their beliefs about DH predisposing factors. RESULTS: Almost all dentists (99%) reported using more than one method to diagnose DH...
January 13, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28060006/resolving-epibole-with-polymeric-membrane-dressings-in-home-care
#3
Kimberly S Bare, Jerri Drain
BACKGROUND: The management of chronic (nonhealing) wounds with epibole is challenging and costly, especially when the problem is not promptly identified or the patient is intolerant to conventional treatments. CASE DESCRIPTION: We describe the use of a polymeric membrane dressing (PMD) in 3 patients with chronic (nonhealing) wounds and epibole who were unable to be treated with traditional interventions such as silver nitrate or sharp debridement. Patient 1 was a 51 year-old male with a right foot stasis ulcer with 60% fibrin/slough to the wound bed, patient 2 was a 58-year-old female with a stage 4 pressure injury of the left hip with undermining, and patient 3 was a 62-year-old female with a dehisced abdominal surgical wound...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28033050/silver-nitrate-interpreted-as-osseous-pathology-on-radiographstwo-case-reports
#4
Jared Clifford
Silver nitrate is often used topically for hemostasis. When radiography is performed after the application of silver nitrate, an artifact appears on the radiograph that may be mistaken for an abnormal calcification or a foreign body. The patients in the following two cases were treated with topical silver nitrate. In each case, radiographs taken after treatment seemed to demonstrate abnormal soft-tissue calcifications in the area of silver nitrate application. Subsequent clinical examination revealed no calcifications, and it was determined that the abnormal radiographic findings were silver nitrate artifacts...
November 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27940398/therapeutic-role-of-nitric-oxide-as-emerging-molecule
#5
REVIEW
Sahil Kumar, Rajesh K Singh, T R Bhardwaj
NO has many physiological roles; in inflammation, pain, rheumatoid arthritis, immune system, gastroprotection, as antioxidant and reported to be a free radical scavenger.Intensive research on the biological functions of NO and other reactive nitrogen oxide species demands exogenous sources of NO donors as research tools and pharmaceuticals. Since the mid-1980s, the development of new NO donors has offered several advantages over theprevious NO donors, such as spontaneous release of NO, donation of NO under controlled rates, and even the targeting of NO to certain tissues...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27907130/environmental-nitrogen-losses-from-commercial-crop-production-systems-in-the-suwannee-river-basin-of-florida
#6
Rishi Prasad, George J Hochmuth
The springs and the Suwannee river of northern Florida in Middle Suwanee River Basin (MSRB) are among several examples in this planet that have shown a temporal trend of increasing nitrate concentration primarily due to the impacts of non-point sources such as agriculture. The rate of nitrate increase in the river as documented by Ham and Hatzell (1996) was 0.02 mg N L-1 y-1. Best management practices (BMPs) for nutrients were adopted by the commercial farms in the MSRB region to reduce the amounts of pollutants entering the water bodies, however the effectiveness of BMPs remains a topic of interest and discussion among the researchers, environmental administrators and policy makers about the loads of nitrogen entering into groundwater and river systems...
2016: PloS One
https://www.readbyqxmd.com/read/27889427/piper-betel-leaves-induces-wound-healing-activity-via-proliferation-of-fibroblasts-and-reducing-11%C3%AE-hydroxysteriod-dehydrogenase-1-expression-in-diabetic-rat
#7
Nur Amalina Ghazali, Azree Elmy, Lee Chee Yuen, Nurul Zaidah Sani, Srijit Das, Farihah Suhaimi, Rafizul Yusof, Nurul Huda Yusoff, Zar Chi Thent
BACKGROUND: Increased oxidative stress and stress enzyme 11β hydroxysteriod dehydrogenase-1 (11β HSD-1) served as the major contributing factors for delayed wound healing in diabetes mellitus (DM). Piper betel (PB) leaves are reported to possess anti-diabetic, anti-oxidant and anti-microbial properties. OBJECTIVE: The objective was to investigate the effectiveness of topical application of PB leaves extract on oxidative stress and 11β hydroxysteriod dehydrogenase-1 (11β HSD-1) expression in diabetic wounds...
October 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27861952/a-possible-approach-to-assess-acidification-of-meat-starter-cultures-a-case-study-from-some-wild-strains-of-lactobacillus-plantarum
#8
Barbara Speranza, Antonio Bevilacqua, Maria Rosaria Corbo, Milena Sinigaglia
BACKGROUND: The performances of four autochthonous isolates of Lactobacillus plantarum were assessed to study the most important variables acting on acidification and to propose a possible step-by-step approach for the validation at laboratory scale. This main topic was addressed through three intermediate steps: (1) evaluation of acidification in liquid and solid media, as a function of salt, nitrites, nitrates, lactose, pepper and temperature; (2) assessing acidification in a pork-meat preparation; and (3) designing a protocol to improve the performances at sub-optimal temperatures...
November 12, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27822687/how-test-vessel-properties-affect-the-fate-of-silver-nitrate-and-sterically-stabilized-silver-nanoparticles-in-two-different-test-designs-used-for-acute-tests-with-daphnia-magna
#9
Yvonne Sakka, Jan Koeser, Juliane Filser
The relation between test conditions such as medium composition or pH on silver nanoparticle (AgNP) behavior and its link to toxicity is one of the major topics in nanoecotoxicological research in the last years. In addition, the adaptation of the ecotoxicological standard tests for nanomaterials is intensely discussed to increase comparability and reliability of results. Due to the limitation of test material production volumes and the need for high-throughput screening, miniaturization has been proposed for several test designs...
November 7, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27807769/nanogels-of-methylcellulose-hydrophobized-with-n-tert-butylacrylamide-for-ocular-drug-delivery
#10
Marion Jamard, Todd Hoare, Heather Sheardown
While eye drops account for the majority of ophthalmic formulation for drug delivery, their efficiency is limited by rapid pre-corneal loss. In this study, we investigate nanogel suspensions in order to improve the topical ocular therapy by reducing dosage and frequency of administration. We synthesized self-assembling nanogels of 140 nm by grafting side chains of poly(N-tert-butylacrylamide) (PNtBAm) on methylcellulose via cerium ammonium nitrate. Successful grafting of PNtBAm onto methylcellulose (MC) was confirmed by both NMR and ATR...
November 2, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27806897/comparison-of-an-everolimus-eluting-bioresorbable-scaffold-with-an-everolimus-eluting-metallic-stent-for-the-treatment-of-coronary-artery-stenosis-absorb-ii-a-3-year-randomised-controlled-single-blind-multicentre-clinical-trial
#11
Patrick W Serruys, Bernard Chevalier, Yohei Sotomi, Angel Cequier, Didier Carrié, Jan J Piek, Ad J Van Boven, Marcello Dominici, Dariusz Dudek, Dougal McClean, Steffen Helqvist, Michael Haude, Sebastian Reith, Manuel de Sousa Almeida, Gianluca Campo, Andrés Iñiguez, Manel Sabaté, Stephan Windecker, Yoshinobu Onuma
BACKGROUND: No medium-term data are available on the random comparison between everolimus-eluting bioresorbable vascular scaffolds and everolimus-eluting metallic stents. The study aims to demonstrate two mechanistic properties of the bioresorbable scaffold: increase in luminal dimensions as a result of recovered vasomotion of the scaffolded vessel. METHODS: The ABSORB II trial is a prospective, randomised, active-controlled, single-blind, parallel two-group, multicentre clinical trial...
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27784258/synthesis-and-characterization-of-silver-nanoparticles-filled-polyethersulfone-membranes-for-antibacterial-and-anti-biofouling-application
#12
Lassaad Gzara, Zulfiqar Ahmad Rehan, Sher Bahadar Khan, Khalid A Alamry, Mohammad Soror El-Shahawi, Mohammad H Albeirutty, Alberto Figoli, Enrico Drioli, Abdullah M Asiri
BACKGROUND: The membrane processes are interesting and economical techniques for reuse of municipal and industrial wastewater as well as seawater desalination. However their drawbacks can be resumed in the fouling and biofouling due to the deposition and adsorption phenomenon of the components and the development of biofilm on membrane surface. Several studies have focused on the effect of the incorporation of nanoparticles in polymeric membrane matrix on the biofouling properties. Few relevant patents to the topic have been reviewed and cited...
October 25, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27777702/bruises-around-the-umbilicus-in-an-infant
#13
Sam Hassan, Ghassan Nakib, Mary J Saviour
The most common causes of umbilical discharge in infancy are infection and umbilical granuloma that may be treated by antibiotics and topical application of silver nitrate subsequently. If the umbilical discharge persists or if there is any abnormal discoloration around the umbilicus, it is important to investigate for underlying congenital abnormality that may be cured by surgical intervention. Unusual presentation of omphalomesenteric duct cyst has been reported in literature. We report, for the first time as far as our search is concerned, a case of a 16-month-old infant who presented initially with persistent umbilical discharge and finally with bruising around the umbilicus in keeping with Cullen's sign...
September 19, 2016: Pediatric Reports
https://www.readbyqxmd.com/read/27760032/efficacy-of-topical-therapy-with-newly-developed-terbinafine-and-econazole-formulations-in-the-treatment-of-dermatophytosis-in-cats
#14
M Ivaskiene, A P Matusevicius, A Grigonis, G Zamokas, L Babickaite
In the field of veterinary dermatology dermatophytosis is one of the most frequently occurring infectious diseases, therefore its treatment should be effective, convenient, safe and inexpensive. The aim of this study was to evaluate the efficacy of newly developed topical formulations in the treatment of cats with dermatophytosis. Evaluation of clinical efficacy and safety of terbinafine and econazole formulations administered topically twice a day was performed in 40 cats. Cats, suffering from the most widely spread Microsporum canis-induced dermatophytosis and treated with terbinafine hydrochloride 1% cream, recovered within 20...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27672587/attenuation-of-corneal-neovascularization-by-topical-low-molecular-weight-heparin-taurocholate-7-without-bleeding-complication
#15
Jae Yong Kim, Soo Yeon Kim, Mi Hyun Cheon, Eun-Soon Kim, In Seok Song, Myoung Joon Kim, Hungwon Tchah
AIM: To investigate the antiangiogenic effects and safety of topically administered low-molecular-weight heparin-taurocholate 7 (LHT7) on corneal neovascularization (CoNV). METHODS: Twenty-four Sprague-Dawley rats were randomly distributed into four groups of six rats each. The central corneas were cauterized using a silver/potassium nitrate solution. From 2d after cauterization, 12.5 mg/mL (low LHT7 group) or 25 mg/mL (high LHT7 group) LHT7 was topically administered three times daily; 12...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27636544/varying-the-morphology-of-silver-nanoparticles-results-in-differential-toxicity-against-micro-organisms-hacat-keratinocytes-and-affects-skin-deposition
#16
Amy M Holmes, Julian Lim, Hauke Studier, Michael S Roberts
The use of silver nanoparticles (Ag NPs) within the healthcare sector and consumer products is rapidly increasing. There are now a range of diverse-shaped Ag NPs that are commercially available and many of the products containing nanosilver are topically applied to human skin. Currently, there is limited data on the extent to which the antimicrobial efficacy and cytotoxicity of Ag NPs is related to their shape and how the shape of the Ag NPs affects their distribution in both intact and burn wounded human skin after topical application...
October 5, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27602974/econazole-nitrate-foam-1-improves-the-itch-of-tinea-pedis
#17
Alan B Fleischer, Isabelle Raymond
Econazole nitrate topical foam, 1%, is indicated for the treatment of interdigital tinea pedis caused by <em>Trichophyton rubrum, Trichophyton mentagrophytes,</em> and <em>Epidermophyton floccosum</em> in patients 12 years of age and older. The symptom of itch or pruritus was evaluated in two randomized, double-blind, parallel-group, vehicle-controlled, multicenter Phase III studies in which econazole foam was compared with foam vehicle in subjects with interdigital tinea pedis. A thin, uniform layer of study treatment was applied once daily to all clinically affected interdigital regions of both feet for four weeks...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27524256/native-prussian-carp-carassius-gibelio-health-status-biochemical-and-histological-responses-to-treated-wastewaters
#18
Natalija Topić Popović, Ivančica Strunjak-Perović, Josip Barišić, Slavko Kepec, Margita Jadan, Blanka Beer-Ljubić, Vesna Matijatko, Dušan Palić, Goran Klobučar, Sanja Babić, Jasenka Gajdoš Kljusurić, Rozelindra Čož-Rakovac
The aim of this study was to assess the impact of treated wastewaters on native wild Prussian carp inhabiting effluent-receiving waters (ERC) receiving municipal and sugar plant treated wastewaters, further downstream waters (DW), and a detached canal unaffected by the WWTP activities. To that end, general fish health status was determined, including plasma biochemical, haematological, oxidative stress and tissue histopathological indices, over three seasons. The greatest tissue alterations were in fall in ERC during sugar beet processing, as hypertrophy of gill epithelial and interlamellar cells, necrosis and lymphocytic infiltration, hyperplasia and hypertrophy of renal tubules, distention of hepatic sinusoids...
November 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27404015/interplay-of-ion-water-and-water-water-interactions-within-the-hydration-shells-of-nitrate-and-carbonate-directly-probed-with-2d-ir-spectroscopy
#19
Joseph A Fournier, William Carpenter, Luigi De Marco, Andrei Tokmakoff
The long-range influence of ions in solution on the water hydrogen-bond (H-bond) network remains a topic of vigorous debate. Recent spectroscopic and theoretical studies have, for the most part, reached the consensus that weakly coordinating ions only affect water molecules in the first hydration shell. Here, we apply ultrafast broadband two-dimensional infrared (2D IR) spectroscopy to aqueous nitrate and carbonate in neat H2O to study the solvation structure and dynamics of ions on opposite ends of the Hofmeister series...
August 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27399763/investigation-of-the-dermal-absorption-and-irritation-potential-of-sertaconazole-nitrate-anhydrous-gel
#20
Mahima Manian, Kumpal Madrasi, Ayyappa Chaturvedula, Ajay K Banga
Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen. In addition, it is important to determine the concentration of the drug in the skin in order to evaluate the subsequent efficacy and potential toxicity for topical formulations. For this purpose, an anhydrous gel containing sertaconazole nitrate as a model drug was formulated and the amount of the drug in the skin was determined by in vitro tape stripping...
2016: Pharmaceutics
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