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Topical Nitrates

Nur Amalina Ghazali, Azree Elmy, Lee Chee Yuen, Nurul Zaidah Sani, Srijit Das, Farihah Suhaimi, Rafizul Yusof, Nurul Huda Yusoff, Zar Chi Thent
BACKGROUND: Increased oxidative stress and stress enzyme 11β hydroxysteriod dehydrogenase-1 (11β HSD-1) served as the major contributing factors for delayed wound healing in diabetes mellitus (DM). Piper betel (PB) leaves are reported to possess anti-diabetic, anti-oxidant and anti-microbial properties. OBJECTIVE: The objective was to investigate the effectiveness of topical application of PB leaves extract on oxidative stress and 11β hydroxysteriod dehydrogenase-1 (11β HSD-1) expression in diabetic wounds...
November 23, 2016: Journal of Ayurveda and Integrative Medicine
Barbara Speranza, Antonio Bevilacqua, Maria Rosaria Corbo, Milena Sinigaglia
BACKGROUND: The performances of four autochthonous isolates of Lactobacillus plantarum were assessed to study the most important variables acting on acidification and propose a possible step-by-step approach for the validation at lab-scale. This main topic was addressed through three intermediate steps: (i) evaluation of acidification in liquid and solid media, as a function of salt, nitrites, nitrates, lactose, pepper and temperature; (ii) assessing acidification in a pork-meat preparation; iii) designing a protocol to improve the performances at sub-optimal temperatures...
November 12, 2016: Journal of the Science of Food and Agriculture
Yvonne Sakka, Jan Koeser, Juliane Filser
The relation between test conditions such as medium composition or pH on silver nanoparticle (AgNP) behavior and its link to toxicity is one of the major topics in nanoecotoxicological research in the last years. In addition, the adaptation of the ecotoxicological standard tests for nanomaterials is intensely discussed to increase comparability and reliability of results. Due to the limitation of test material production volumes and the need for high-throughput screening, miniaturization has been proposed for several test designs...
November 7, 2016: Environmental Science and Pollution Research International
Marion Jamard, Todd Hoare, Heather Sheardown
While eye drops account for the majority of ophthalmic formulation for drug delivery, their efficiency is limited by rapid pre-corneal loss. In this study, we investigate nanogel suspensions in order to improve the topical ocular therapy by reducing dosage and frequency of administration. We synthesized self-assembling nanogels of 140 nm by grafting side chains of poly(N-tert-butylacrylamide) (PNtBAm) on methylcellulose via cerium ammonium nitrate. Successful grafting of PNtBAm onto methylcellulose (MC) was confirmed by both NMR and ATR...
November 2, 2016: Drug Delivery and Translational Research
Patrick W Serruys, Bernard Chevalier, Yohei Sotomi, Angel Cequier, Didier Carrié, Jan J Piek, Ad J Van Boven, Marcello Dominici, Dariusz Dudek, Dougal McClean, Steffen Helqvist, Michael Haude, Sebastian Reith, Manuel de Sousa Almeida, Gianluca Campo, Andrés Iñiguez, Manel Sabaté, Stephan Windecker, Yoshinobu Onuma
BACKGROUND: No medium-term data are available on the random comparison between everolimus-eluting bioresorbable vascular scaffolds and everolimus-eluting metallic stents. The study aims to demonstrate two mechanistic properties of the bioresorbable scaffold: increase in luminal dimensions as a result of recovered vasomotion of the scaffolded vessel. METHODS: The ABSORB II trial is a prospective, randomised, active-controlled, single-blind, parallel two-group, multicentre clinical trial...
November 19, 2016: Lancet
Lassaad Gzara, Zulfiqar Ahmad Rehan, Sher Bahadar Khan, Khalid A Alamry, Mohammad Soror El-Shahawi, Mohammad H Albeirutty, Alberto Figoli, Enrico Drioli, Abdullah M Asiri
BACKGROUND: The membrane processes are interesting and economical techniques for reuse of municipal and industrial wastewater as well as seawater desalination. However their drawbacks can be resumed in the fouling and biofouling due to the deposition and adsorption phenomenon of the components and the development of biofilm on membrane surface. Several studies have focused on the effect of the incorporation of nanoparticles in polymeric membrane matrix on the biofouling properties. Few relevant patents to the topic have been reviewed and cited...
October 25, 2016: Recent Patents on Nanotechnology
Sam Hassan, Ghassan Nakib, Mary J Saviour
The most common causes of umbilical discharge in infancy are infection and umbilical granuloma that may be treated by antibiotics and topical application of silver nitrate subsequently. If the umbilical discharge persists or if there is any abnormal discoloration around the umbilicus, it is important to investigate for underlying congenital abnormality that may be cured by surgical intervention. Unusual presentation of omphalomesenteric duct cyst has been reported in literature. We report, for the first time as far as our search is concerned, a case of a 16-month-old infant who presented initially with persistent umbilical discharge and finally with bruising around the umbilicus in keeping with Cullen's sign...
September 19, 2016: Pediatric Reports
M Ivaskiene, A P Matusevicius, A Grigonis, G Zamokas, L Babickaite
In the field of veterinary dermatology dermatophytosis is one of the most frequently occurring infectious diseases, therefore its treatment should be effective, convenient, safe and inexpensive. The aim of this study was to evaluate the efficacy of newly developed topical formulations in the treatment of cats with dermatophytosis. Evaluation of clinical efficacy and safety of terbinafine and econazole formulations administered topically twice a day was performed in 40 cats. Cats, suffering from the most widely spread Microsporum canis-induced dermatophytosis and treated with terbinafine hydrochloride 1% cream, recovered within 20...
September 1, 2016: Polish Journal of Veterinary Sciences
Jae Yong Kim, Soo Yeon Kim, Mi Hyun Cheon, Eun-Soon Kim, In Seok Song, Myoung Joon Kim, Hungwon Tchah
AIM: To investigate the antiangiogenic effects and safety of topically administered low-molecular-weight heparin-taurocholate 7 (LHT7) on corneal neovascularization (CoNV). METHODS: Twenty-four Sprague-Dawley rats were randomly distributed into four groups of six rats each. The central corneas were cauterized using a silver/potassium nitrate solution. From 2d after cauterization, 12.5 mg/mL (low LHT7 group) or 25 mg/mL (high LHT7 group) LHT7 was topically administered three times daily; 12...
2016: International Journal of Ophthalmology
Amy M Holmes, Julian Lim, Hauke Studier, Michael S Roberts
The use of silver nanoparticles (Ag NPs) within the healthcare sector and consumer products is rapidly increasing. There are now a range of diverse-shaped Ag NPs that are commercially available and many of the products containing nanosilver are topically applied to human skin. Currently, there is limited data on the extent to which the antimicrobial efficacy and cytotoxicity of Ag NPs is related to their shape and how the shape of the Ag NPs affects their distribution in both intact and burn wounded human skin after topical application...
October 5, 2016: Nanotoxicology
Alan B Fleischer, Isabelle Raymond
Econazole nitrate topical foam, 1%, is indicated for the treatment of interdigital tinea pedis caused by <em>Trichophyton rubrum, Trichophyton mentagrophytes,</em> and <em>Epidermophyton floccosum</em> in patients 12 years of age and older. The symptom of itch or pruritus was evaluated in two randomized, double-blind, parallel-group, vehicle-controlled, multicenter Phase III studies in which econazole foam was compared with foam vehicle in subjects with interdigital tinea pedis. A thin, uniform layer of study treatment was applied once daily to all clinically affected interdigital regions of both feet for four weeks...
September 1, 2016: Journal of Drugs in Dermatology: JDD
Natalija Topić Popović, Ivančica Strunjak-Perović, Josip Barišić, Slavko Kepec, Margita Jadan, Blanka Beer-Ljubić, Vesna Matijatko, Dušan Palić, Goran Klobučar, Sanja Babić, Jasenka Gajdoš Kljusurić, Rozelindra Čož-Rakovac
The aim of this study was to assess the impact of treated wastewaters on native wild Prussian carp inhabiting effluent-receiving waters (ERC) receiving municipal and sugar plant treated wastewaters, further downstream waters (DW), and a detached canal unaffected by the WWTP activities. To that end, general fish health status was determined, including plasma biochemical, haematological, oxidative stress and tissue histopathological indices, over three seasons. The greatest tissue alterations were in fall in ERC during sugar beet processing, as hypertrophy of gill epithelial and interlamellar cells, necrosis and lymphocytic infiltration, hyperplasia and hypertrophy of renal tubules, distention of hepatic sinusoids...
November 2016: Environmental Pollution
Joseph A Fournier, William Carpenter, Luigi De Marco, Andrei Tokmakoff
The long-range influence of ions in solution on the water hydrogen-bond (H-bond) network remains a topic of vigorous debate. Recent spectroscopic and theoretical studies have, for the most part, reached the consensus that weakly coordinating ions only affect water molecules in the first hydration shell. Here, we apply ultrafast broadband two-dimensional infrared (2D IR) spectroscopy to aqueous nitrate and carbonate in neat H2O to study the solvation structure and dynamics of ions on opposite ends of the Hofmeister series...
August 3, 2016: Journal of the American Chemical Society
Mahima Manian, Kumpal Madrasi, Ayyappa Chaturvedula, Ajay K Banga
Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen. In addition, it is important to determine the concentration of the drug in the skin in order to evaluate the subsequent efficacy and potential toxicity for topical formulations. For this purpose, an anhydrous gel containing sertaconazole nitrate as a model drug was formulated and the amount of the drug in the skin was determined by in vitro tape stripping...
2016: Pharmaceutics
Mollie L Mesman, Allison L Kirby, Wayne S Rosenkrantz, Craig E Griffin
BACKGROUND: Topical antimicrobial therapy is increasingly important in the treatment of canine pyoderma as the incidence of multidrug resistance has risen. However, little information is reported on the persistence of activity of topical antimicrobial products. OBJECTIVE: To determine the residual antibacterial activity of canine hairs treated with antimicrobial sprays. ANIMALS: Twelve privately owned dogs with no history of dermatological disease...
August 2016: Veterinary Dermatology
Sarita Tiwari, Bijaya Ketan Sarangi, Sanjog T Thul
Mitigation of arsenic (As) pollution is a topical environmental issue of high R&D priority. The present investigation was carried out to isolate As resistant endophytes from the roots of Indian ecotype Pteris vittata and characterize their As transformation and tolerance ability, plant growth promoting characteristics and their role to facilitate As uptake by the plant. A total of 8 root endophytes were isolated from plants grown in As amended soil (25 mg As kg(-1)). These isolates were studied for minimum inhibitory concentration (MIC), arsenite As(III) - arsenate As(V) transformation ability, plant growth promoting (PGP) characteristics through siderophore, indole acetic acid (IAA) production, phosphatase, ACC deaminase activity, and presence of arsenite oxidase (aox) and arsenite transporter (arsB) genes...
September 15, 2016: Journal of Environmental Management
Manuel Lasch, Amelia Caballero-Martinez, Kerstin Troidl, Irmengard Schloegl, Thomas Lautz, Elisabeth Deindl
l-Arginine is the common substrate for nitric oxide synthases (NOS) and arginase. Whereas the contribution of NOS to collateral artery growth (arteriogenesis) has been demonstrated, the functional role of arginase remains to be elucidated and was topic of the present study. Arteriogenesis was induced in mice by ligation of the femoral artery. Laser Doppler perfusion measurements demonstrated a significant reduction in arteriogenesis in mice treated with the arginase inhibitor nor-NOHA (N(ω)-hydroxy-nor-arginine)...
August 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
Yuan Lei, Maomao Song, Jihong Wu, Chao Xing, Xinghuai Sun
PURPOSE: To investigate endothelial nitric oxide synthase (eNOS) activity and the response of conventional outflow facility to nitric oxide donors and a nitric oxide synthase (NOS) inhibitor in caveolin-1 (CAV1) knockout (KO) mice. METHODS: Intraocular pressure (IOP) was measured in both CAV1 KO and wild-type (WT) mice by rebound tonometry. The expressions of caveolin-2 (CAV2), eNOS, eNOS-phospho Ser1177, eNOS-phospho Thr495, Akt, Akt-phospho Ser473, and nitrotyrosin were measured by Western blot analysis...
May 1, 2016: Investigative Ophthalmology & Visual Science
Aisah A Aubdool, Xenia Kodji, Nayaab Abdul-Kader, Richard Heads, Elizabeth S Fernandes, Stuart Bevan, Susan D Brain
BACKGROUND AND PURPOSE: Transient receptor potential ankyrin-1 (TRPA1) activation is known to mediate neurogenic vasodilatation. We investigated the mechanisms involved in TRPA1-mediated peripheral vasodilatation in vivo using the TRPA1 agonist cinnamaldehyde. EXPERIMENTAL APPROACH: Changes in vascular ear blood flow were measured in anaesthetized mice using laser Doppler flowmetry. KEY RESULTS: Topical application of cinnamaldehyde to the mouse ear caused a significant increase in blood flow in the skin of anaesthetized wild-type (WT) mice but not in TRPA1 knockout (KO) mice...
August 2016: British Journal of Pharmacology
Zulfiqar Ahmad Rehan, Lassaad Gzara, Sher Bahadar Khan, Khalid A Alamry, M S El-Shahawi, Mohammad H Albeirutty, Alberto Figoli, Enrico Drioli, Abdullah M Asiri
BACKGROUND: The membrane processes are interesting and economical techniques for reuse of municipal and industrial wastewater as well as seawater desalination. Several studies have focused on the effect of the incorporation of nanoparticles in polymeric membrane matrix on the biofouling properties. Few relevant patents to the topic have been reviewed and cited. METHODS: Polyethersulfone (PES) membranes filled with silver nanoparticles AgNPs were prepared by non-solvent induced phase separation (NIPS) process using polyvinylpyrrolidone (PVP) as additive and N-Methyl-2-pyrrolidone (NMP) as solvent...
April 29, 2016: Recent Patents on Nanotechnology
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