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painful bladder syndrome

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https://www.readbyqxmd.com/read/29784661/linaclotide-attenuates-visceral-organ-crosstalk-role-of-guanylate-cyclase-c-activation-in-reversing-bladder-colon-cross-sensitization
#1
Ehsan N Mohammadi, Casey O Ligon, Ada Silos-Santiago, Pei Ge, Caroline Kurtz, Carolyn Higgins, Gerhard Hannig, Beverley Greenwood-Van Meerveld
INTRODUCTION: Bladder pain syndrome (BPS) is poorly understood, however there is evidence of a female predominance and co-morbidity with irritable bowel syndrome (IBS). Here we test the hypothesis that linaclotide, a guanylate cyclase-C (GC-C) agonist approved for the treatment of IBS with constipation (IBS-C), may represent a novel therapeutic for BPS acting through a mechanism involving an inhibition of visceral organ cross sensitization. METHODS: In female rats, infusion of dilute protamine sulfate (PS) into the bladder was employed to induce bladder and colonic hypersensitivity...
May 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29784508/il-33-mast-cell-axis-is-central-in-ll-37-induced-bladder-inflammation-and-pain-in-a-murine-interstitial-cystitis-model
#2
M Martin Jensen, Wanjian Jia, Austin J Schults, Xiangyang Ye, Glenn D Prestwich, Siam Oottamasathien
Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is a debilitating chronic condition that afflicts over 3 million women above the age of 18 in the U.S., and most patients fail to respond to current treatment options. Mast cells have previously been implicated as both a diagnostic and prognostic marker in IC/PBS. Patients with IC/PBS have been shown to have elevated levels of IL-33, a cytokine released in response to tissue insult, in their urine. We hypothesize that mast cell-mediated inflammation induced from IL-33 may play an important role in initiating pain and inflammation in IC/PBS...
May 18, 2018: Cytokine
https://www.readbyqxmd.com/read/29782887/endoscopic-injection-of-low-dose-triamcinolone-a-simple-minimally-invasive-and-effective-therapy-for-interstitial-cystitis-with-hunner-lesions
#3
Michael G Funaro, Alexandra N King, Joel N H Stern, Robert M Moldwin, Sonia Bahlani
OBJECTIVES: To investigate the efficacy of low dose triamcinolone injection for effectiveness and durability in interstitial cystitis/bladder pain syndrome (IC/BPS) patients with Hunner Lesions (HL). MATERIALS & METHODS: Clinical data from patients with HL who underwent endoscopic submucosal injection of triamcinolone were reviewed: Demographics, pre/post operative pain and nocturia scores, and long-term clinical outcomes were assessed. Duration of response was estimated by time to repeat procedure...
May 18, 2018: Urology
https://www.readbyqxmd.com/read/29777618/guideline-of-guidelines-bladder-pain-syndrome
#4
REVIEW
Sachin Malde, Stefano Palmisani, Adnan Al-Kaisy, Arun Sahai
Bladder pain syndrome (BPS) is a severely debilitating, chronic disorder of unknown aetiology that has a significant negative impact on quality of life. A community-based study of American women has reported a high prevalence of 2.7% - 6.5% [1]. Despite this, there is still a lack of consensus worldwide on how to define the condition, the nomenclature to use, and how to optimally treat patients. This is reflected in the considerable variation in management worldwide, and the divergent recommendations in national and international guidelines...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29775697/prodrome-and-non-prodrome-phenotypes-of-bladder-pain-syndrome-interstitial-cystitis
#5
John W Warren, Ningbo Jian, Lisa Gallicchio, David Wu, Daniel J Clauw
OBJECTIVE: To test the hypothesis that risk factors for BPS/IC in women differ between those with and without the BPS/IC prodrome. METHODS: Incident cases of BPS/IC and healthy controls were recruited nationally. More than half the BPS/IC cases reported subsyndromal urinary symptoms for decades before onset of BPS/IC and were identified as having the prodrome. Risk factors for BPS/IC were examined separately for cases with and without the prodrome using a set of matched controls...
May 15, 2018: Urology
https://www.readbyqxmd.com/read/29774817/bladder-reconstruction-with-bowel-robot-assisted-laparoscopic-ileocystoplasty-with-mitrofanoff-appendicovesicostomy-in-pediatric-patients
#6
Nimrod S Barashi, Maria Veronica Rodriguez, Vignesh T Packiam, Mohan S Gundeti
Neurogenic bladder occur as a consequence of several conditions, most commonly posterior urethral valves syndrome, spina bifida, tethered cord, sacral agenesis, and Arnold-Chiari malformation. It is characterized by diminished bladder capacity and/or reduced compliance, associated with high-pressure voiding that can lead to deterioration of renal function if left untreated. When medical management fails, bladder reconstruction with bowel (aumentation ileocystoplasty) becomes the treatment of choice for these patients...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29764932/distribution-of-mast-cell-subtypes-in-interstitial-cystitis-implications-for-novel-diagnostic-and-therapeutic-strategies
#7
Shabana T Malik, Brian R Birch, David Voegeli, Mandy Fader, Vipul Foria, Alan J Cooper, Andrew F Walls, Bashir A Lwaleed
AIMS: To identify the presence and geographical distribution of mast cell (MC) subtypes: MCT (tryptase positive-chymase negative) and MCTC (tryptase positive-chymase positive) in bladder tissue. METHODS: Bladder tissue was obtained from patients with painful bladder syndrome/interstitial cystitis (n=14) and normal histology from University Hospital Southampton tissue bank. Sequential tissue slices were immunohistochemically stained for MC subtypes using anti-MC tryptase (for MCT and MCTC ) and anti-MC chymase (for MCTC )...
May 15, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29753213/onabotulinumtoxina-detrusor-injection-improves-female-sexual-function-in-women-with-overactive-bladder-wet-syndrome
#8
Matteo Balzarro, Emanuele Rubilotta, Andrea Braga, Silvia Bassi, Tania Processali, Walter Artibani, Maurizio Serati
OBJECTIVES: The correlation between changes in sexual function and improvements in LUTD in patients treated with OnabotulinumtoxinA (onaBoNT-A) detrusor injection is unclear and limited only to women with neurogenic OAB. The aim of this study was to evaluate the impact of OnabotulinumtoxinA (onaBoNT-A) injection on sexual function in women undergoing this treatment for idiopathic wet overactive bladder (OAB). STUDY DESIGN: This is a pilot three-center observational study including women affected by idiopathic wet overactive bladder refractory to standard conservative treatments and underwent onaBoNT-A injection...
May 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29726290/alpha-lipoic-acid-in-obstetrics-and-gynecology
#9
Chiara Di Tucci, Mara Di Feliciantonio, Flaminia Vena, Carmela Capone, Michele Carlo Schiavi, Daniela Pietrangeli, Ludovico Muzii, Pierluigi Benedetti Panici
Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate. In this review, we analyzed the action of ALA in gynecology and obstetrics focusing in particular on neuropathic pain and antioxidant and anti-inflammatory action. A comprehensive literature search was performed in PubMed and Cochrane Library for retrieving articles in English language on the antioxidant and anti-inflammatory effects of ALA in gynecological and obstetrical conditions...
May 4, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29717937/deletion-or-pharmacological-blockade-of-toll-like-receptor-4-tlr4-confers-protection-against-cyclophosphamide-induced-mouse-cystitis
#10
Mariana G de Oliveira, Fabiola Zakia Mónica, Fabiano B Calmasini, Eduardo C Alexandre, Edith B G Tavares, Antonio G Soares, Soraia K P Costa, Edson Antunes
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic inflammatory disease without consistently effective treatment. We investigate the role of toll-like receptor (TLR4) on voiding dysfunction and inflammation in the cyclophosphamide (CYP)-induced mouse cystitis. Males C57BL/6 (wild-type, WT) and/or TLR4 knockout (TLR4-/-) were treated with an injection of CYP (300 mg/kg, 24 h) or saline (10 ml/kg). The pharmacological blockade of the TLR4 by resatorvid (10 mg/kg) was also performed 1 h prior CYP-injection in WT mice...
May 2, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29717503/will-cesarean-section-increase-the-risk-of-interstitial-cystitis-painful-bladder-syndrome
#11
Kun-Min Chang, Ming-Huei Lee, Hsuan-Hung Lin, Shang-Liang Wu, Huei-Ching Wu
AIMS: A high number of patients with interstitial cystitis/painful bladder syndrome (IC/PBS) have a history of pelvic surgeries, and cesarean section is one of the most common pelvic surgeries in women. This study aimed to investigate if cesarean section increases the risk of IC/PBS. METHODS: Women who exclusively gave birth through cesarean section or vaginal delivery were identified from a nationwide database between 2002 and 2013. All were followed up during the study period to detect the event of IC/PBS...
May 1, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29706873/inflammation-and-tissue-remodeling-in-the-bladder-and-urethra-in-feline-interstitial-cystitis
#12
F Aura Kullmann, Bronagh M McDonnell, Amanda S Wolf-Johnston, Andrew M Lynn, Samuel E Getchell, Wily G Ruiz, Irina V Zabbarova, Youko Ikeda, Anthony J Kanai, James R Roppolo, Sheldon I Bastacky, Gerard Apodaca, C A Tony Buffington, Lori A Birder
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic disease of unknown etiology. A naturally occurring disease termed feline interstitial cystitis (FIC) reproduces many features of IC/BPS patients. To gain insights into mechanisms underlying IC/BPS, we investigated pathological changes in the lamina propria (LP) of the bladder and proximal urethra in cats with FIC, using histological and molecular methods. Compared to control cat tissue, we found an increased number of de-granulated mast cells, accumulation of leukocytes, increased cyclooxygenase (COX)-1 expression in the bladder LP, and increased COX-2 expression in the urethra LP from cats with FIC...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29704486/identification-of-experimental-bladder-sensitivity-among-dysmenorrhea-sufferers
#13
Kevin M Hellman, Avisek Datta, Nicole D Steiner, Julia N Kane Morlock, Ellen F Garrison, Daniel J Clauw, Frank F Tu
BACKGROUND: Dysmenorrhea is a common risk factor for chronic pain conditions including bladder pain syndrome. Few studies have formally evaluated asymptomatic bladder pain sensitivity in dysmenorrhea, and whether this largely reflects excess pelvic symptom reporting due to comorbid psychological dysfunction. OBJECTIVE: We sought to determine whether bladder hypersensitivity is more common among women reporting moderate or greater dysmenorrhea, without chronic pain elsewhere, after accounting for anxiety and depression...
April 25, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29700406/sub-noxious-intravesical-lipopolysaccharide-triggers-bladder-inflammation-and-symptom-onset-in-a-transgenic-autoimmune-cystitis-model-a-mapp-network-animal-study
#14
Paul Kogan, Suming Xu, Yaoqin Wang, Michael A O'Donnell, Susan K Lutgendorf, Catherine S Bradley, Andrew Schrepf, Karl J Kreder, Yi Luo
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) can potentially develop symptom flares after exposure to minor bladder irritants such as subclinical bacterial infection. To reproduce this symptom onset, we intravesically instilled a sub-noxious dose of uropathogenic E. coli component lipopolysaccharide (LPS) in young URO-OVA/OT-I mice, a transgenic autoimmune cystitis model that spontaneously develops bladder inflammation at ≥10 weeks of age. Female URO-OVA/OT-I mice (6-weeks old) were treated intravesically with phosphate-buffered saline (PBS) or PBS containing a sub-noxious dose (1 μg) of LPS...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29680002/improving-the-utility-of-clinical-phenotyping-in-interstitial-cystitis-painful-bladder-syndrome-from-upoint-to-input
#15
Alice Crane, Jessica Lloyd, Daniel A Shoskes
INTRODUCTION: The phenotyping system UPOINT has proven effective in classifying patients with Urologic Pelvic Pain Syndromes in a clinically meaningful way and to guide therapy. While highly successful in men with chronic pelvic pain syndrome (CPPS), UPOINT is more limited in patients with interstitial cystitis/painful bladder syndrome (IC/PBS) since by definition all patients have the urinary and organ specific phenotype. Furthermore, AUA guidelines recommend a sequential tiered approach to therapy rather than the multimodal UPOINT scheme...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29665997/lower-urinary-tract-symptoms-what-s-new-in-medical-treatment
#16
REVIEW
Benoit Peyronnet, Benjamin M Brucker, Martin C Michel
CONTEXT: Pharmacological treatment is a cornerstone in the management of patients with lower urinary tract symptoms (LUTS). OBJECTIVE: To review emerging evidence in the medical treatment of LUTS. EVIDENCE ACQUISITION: An Embase/Pubmed-based literature search was conducted in December 2017, screening for randomized controlled trials (RCTs), prospective and retrospective series, animal model studies, and reviews on medical treatment of LUTS...
April 14, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29657470/influence-of-timing-of-surgery-on-cauda-equina-syndrome-outcomes-at-a-national-spinal-centre
#17
Gavin Heyes, Morgan Jones, Eugene Verzin, Greg McLorinan, Nagy Darwish, Niall Eames
Purpose: There is no doubt that the best outcome achieved in Cauda equina syndrome (CES) involves surgical decompression. The controversy regarding outcome lies with timing of surgery. This study reports outcomes on a large population based series. Timing of surgery, Cauda Equina syndrome classification based on British Association of Spine Surgeons (BASS) guidelines and co-morbid illness will be assessed to evaluate influence on outcome. Materials and methods: A retrospective review of all patients surgically decompressed for CES between 01/01/2008 to 01/08/2014 was conducted...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29653163/epstein-barr-virus-presence-as-a-potential-etiology-of-persistent-bladder-inflammation-in-human-interstitial-cystitis-bladder-pain-syndrome
#18
Jia-Fong Jhang, Yung-Hsiang Hsu, Chih-Wen Peng, Yuan-Hong Jiang, Han-Chen Ho, Hann-Chorng Kuo
PURPOSE: Interstitial cystitis/bladder pain syndrome is characterized by bladder inflammation without a bacterial infection. Although viral infection is a potential etiologic cause, few studies are reported. MATERIAL AND METHODS: Bladder specimens were obtained from patients with interstitial cystitis/bladder pain syndrome and patients with stress urinary incontinence (control). Bladder specimens were tested for Epstein-Barr-encoded RNAs by in situ hybridization, Epstein-Barr DNA by quantitative real-time polymerase chain reaction (qPCR), serology, and immunohistochemical staining...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29650471/validation-of-the-spanish-version-of-the-bladder-pain-interstitial-cystitis-symptom-score-bpic-ss-questionnaire-a-useful-tool-for-the-diagnosis-of-bladder-pain-syndrome
#19
S Arlandis, A Franco, A M Mora, P Rebollo
OBJECTIVES: Validation of the Spanish version of the Bladder Pain/Interstitial Cystitis-Symptom Score (BPIC-SS) questionnaire to evaluate its utility for the diagnosis of Bladder Pain Syndrome (BPS) patients in the Female and Urodynamics Urology Functional Units in Spain. MATERIAL AND METHODS: The Spanish adaptation of the BPIC-SS questionnaire was evaluated in 243 BPS patients. EQ-5D-5L, Patient Perception of Bladder Condition (PPBC) and global impression questionnaire (CGI-S) were collected...
April 9, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29649647/the-clinical-outcomes-of-primary-and-revision-untethering-surgery-in-patients-with-tethered-cord-syndrome-and-spinal-bifida
#20
Jingchuan Sun, Yao Zhang, Haibo Wang, Yuan Wang, Yong Yang, Qingjie Kong, Ximing Xu, Jiangang Shi
BACKGROUND: Tethered cord syndrome (TCS) is an increasingly recognized clinical condition, with untethering surgery as the classically effective treatment. Yet, as evidence aggregated, the surgical outcome untethering, remains controversial. This study aimed to systematically evaluate the clinical outcomes after untethering surgery in primary and re-tethering patients. METHODS: This retrospective study was conducted by department of spine surgery of Changzheng Hospital from January to December 2016...
April 9, 2018: World Neurosurgery
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