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https://www.readbyqxmd.com/read/27895554/systemic-radical-scavenger-treatment-of-a-mouse-model-of-rett-syndrome-merits-and-limitations-of-the-vitamin-e-derivative-trolox
#1
Oliwia A Janc, Marc A Hüser, Katharina Dietrich, Belinda Kempkes, Christiane Menzfeld, Swen Hülsmann, Michael Müller
Rett syndrome (RTT) is a severe neurodevelopmental disorder typically arising from spontaneous mutations in the X-chromosomal methyl-CpG binding protein 2 (MECP2) gene. The almost exclusively female Rett patients show an apparently normal development during their first 6-18 months of life. Subsequently, cognitive- and motor-impairment, hand stereotypies, loss of learned skills, epilepsy and irregular breathing manifest. Early mitochondrial impairment and oxidative challenge are considered to facilitate disease progression...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27784476/-effects-of-prenatal-maternal-seizure-on-hippocampal-damage-and-cognitive-deficits-in-offspring-rats
#2
Y Lu, W P Wang, X X Wang, J J Feng, Z P Guo, L M Liu, T Xie, R R Zhao, Y L Cai
Objective: To observe hippocampal damage and cognitive impairment of offspring exposed to prenatal maternal seizure induced by amygdala kindling, and to explore the underlying mechanism by the detection of pathological changes of placenta. Method: Adult female SD rats were randomly divided into three groups: control group(8 rats), kindling group(12 rats) and sham group(8 rats). All the rats were allowed to mate after one week's fully kindling. The pregnant rats in kindling group received electric stimulation every 48 h...
October 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27630206/increased-interleukin-32-levels-in-obesity-promote-adipose-tissue-inflammation-and-extracellular-matrix-remodeling-effect-of-weight-loss
#3
Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Manuel F Landecho, Camilo Silva, Javier Salvador, Gema Frühbeck
Interleukin (IL)-32 is a recently described cytokine involved in the regulation of inflammation. We aimed to explore whether IL-32 could function as an inflammatory and angiogenic factor in human obesity and obesity-associated type 2 diabetes. Samples obtained from 90 subjects were used in the study. Obese patients exhibited higher expression levels of IL-32 in visceral adipose tissue (AT) as well as in subcutaneous AT and peripheral blood mononuclear cells. IL32 was mainly expressed by stromovascular fraction cells, and its expression was significantly enhanced by inflammatory stimuli and hypoxia, whereas no changes were found after the incubation with anti-inflammatory cytokines...
December 2016: Diabetes
https://www.readbyqxmd.com/read/27628483/hypoxia-driven-hif2a-coordinates-mouse-liver-regeneration-by-coupling-parenchymal-growth-to-vascular-expansion
#4
Philipp Kron, Michael Linecker, Perparim Limani, Andrea Schlegel, Patryk Kambakamba, Jean-Marie Lehn, Claude Nicolau, Rolf Graf, Bostjan Humar, Pierre-Alain Clavien
: Interaction between sinusoidal endothelial cells and hepatocytes is a prerequisite for liver function. Upon tissue loss, both liver cell populations need to be regenerated. Repopulation occurs in a coordinated pattern, first through the regeneration of parenchyme (hepatocytes), which then produces vascular endothelial growth factor (VEGF) to enable the subsequent angiogenic phase. The signals that instruct hepatocytes to induce timely VEGF remain unidentified. Given that liver is highly vascularized, we reasoned that fluctuations in oxygenation after tissue loss may contribute to the coordination between hepatocyte and sinusoidal endothelial cell proliferation...
September 15, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27624688/increased-hemoglobin-oxygen-affinity-ameliorates-bleomycin-induced-hypoxemia-and-pulmonary-fibrosis
#5
Xin Geng, Kobina Dufu, Athiwat Hutchaleelaha, Qing Xu, Zhe Li, Chien-Ming Li, Mira P Patel, Nicholas Vlahakis, Josh Lehrer-Graiwer, Donna Oksenberg
Although exertional dyspnea and worsening hypoxia are hallmark clinical features of idiopathic pulmonary fibrosis (IPF), no drug currently available could treat them. GBT1118 is a novel orally bioavailable small molecule that binds to hemoglobin and produces a concentration-dependent left shift of the oxygen-hemoglobin dissociation curve with subsequent increase in hemoglobin-oxygen affinity and arterial oxygen loading. To assess whether pharmacological modification of hemoglobin-oxygen affinity could ameliorate hypoxemia associated with lung fibrosis, we evaluated GBT1118 in a bleomycin-induced mouse model of hypoxemia and fibrosis...
September 2016: Physiological Reports
https://www.readbyqxmd.com/read/27578020/sodium-butyrate-a-histone-deacetylase-inhibitor-exhibits-neuroprotective-neurogenic-effects-in-a-rat-model-of-neonatal-hypoxia-ischemia
#6
Malgorzata Ziemka-Nalecz, Joanna Jaworska, Joanna Sypecka, Rafał Polowy, Robert K Filipkowski, Teresa Zalewska
Neonatal hypoxic-ischemic (HI) injury still remains an important issue as it is a major cause of neonatal death and neurological dysfunctions. Currently, there are no well-established treatments to reduce brain damage and its long-term sequel in infants. Recently, reported data show that histone deacetylase inhibitors provide neuroprotection in adult stroke models. However, the proof of their relevance in vivo after neonatal HI brain injury remains particularly limited. In the present study, we show neuroprotective/neurogenic effect of sodium butyrate (SB), one of histone deacetylase inhibitors (HDACis), in the dentate gyrus of HI-injured immature rats...
August 30, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27570189/selective-accumulation-of-biotin-in-arterial-chemoreceptors-requirement-for-carotid-body-exocytotic-dopamine-secretion
#7
Patricia Ortega-Sáenz, David Macías, Konstantin L Levitsky, José A Rodríguez-Gómez, Patricia González-Rodríguez, Victoria Bonilla-Henao, Ignacio Arias-Mayenco, José López-Barneo
KEY POINTS: Biotin, a vitamin whose main role is as a coenzyme for carboxylases, accumulates at unusually large amounts within cells of the carotid body (CB). In biotin-deficient rats biotin rapidly disappears from the blood; however, it remains at relatively high levels in CB glomus cells. The CB contains high levels of mRNA for SLC5a6, a biotin transporter, and SLC19a3, a thiamine transporter regulated by biotin. Animals with biotin deficiency exhibit pronounced metabolic lactic acidosis...
August 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27552063/combining-hypobaric-hypoxia-or-hyperbaric-oxygen-postconditioning-with-memantine-reduces-neuroprotection-in-7-day-old-rat-hypoxia-ischemia
#8
Marcin Gamdzyk, Apolonia Ziembowicz, Ewelina Bratek, Elzbieta Salinska
BACKGROUND: Perinatal hypoxia-ischemia causes brain injury in neonates, but a fully successful treatment to prevent changes in the brain has yet to be developed. The aim of this study was to evaluate the effect of combining memantine treatment with HBO (2.5 ATA) or HH (0.47 ATA) on neonatal hypoxia-ischemia brain injury. METHODS: 7-day old rats were subjected to hypoxia-ischemia (H-I) and treated with combination of memantine and HBO or HH. The brain damage was evaluated by examination of infarct area and the number of apoptotic cells in CA1 region of hippocampus...
October 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27380075/illinois-river-nitrate-nitrogen-concentrations-and-loads-long-term-variation-and-association-with-watershed-nitrogen-inputs
#9
Gregory F McIsaac, Mark B David, George Z Gertner
The Illinois River is a major contributor of nitrate-N to the Mississippi River and the Gulf of Mexico, where nitrate is a leading cause of summertime benthic hypoxia. Corn-soybean production on tile-drained land is a leading source of nitrate-N in this river system, in addition to municipal wastewater discharge. We calculated annual nitrate-N loads in the Illinois River at Valley City from 1976 to 2014 by linear interpolation. Although there was not a significant trend in annual loads during the entire study period, there was a significant downward trend in flow-weighted nitrate-N concentration after 1990 despite high concentrations in 2013 after the 2012 drought...
July 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27324067/nonalcoholic-fatty-liver-disease-and-obstructive-sleep-apnea
#10
Judith Aron-Wisnewsky, Karine Clement, Jean-Louis Pépin
Obstructive sleep apnea (OSA) and more importantly its hallmark, chronic intermittent hypoxia (CIH), are established factors in the pathogenesis and exacerbation of nonalcoholic fatty liver disease (NAFLD). This has been clearly demonstrated in rodent models exposed to intermittent hypoxia, and strong evidence now also exists in both paediatric and adult human populations. OSA and CIH induce insulin-resistance and dyslipidemia which are involved in NAFLD physiopathogenesis. CIH increases the expression of the hypoxia inducible transcription factor HIF1α and that of downstream genes involved in lipogenesis, thereby increasing β-oxidation and consequently exacerbating liver oxidative stress...
August 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27267822/involvement-of-hypoxia-inducible-factor-1-%C3%AE-hif-1%C3%AE-in-inhibition-of-benzene-on-mouse-hematopoietic-system
#11
Xing Meng, Juan Zhang, Lihong Yin, Yuepu Pu
Benzene is an occupational and environmental pollutant that damages the hematopoietic system through oxidant mechanisms. The aims of this study were to assess the role of oxidation in benzene-mediated damage by determination of the levels of reactive oxygen species (ROS) and to evaluate the role of hypoxia-inducible factor-1α (HIF-1α) in this process. C57BL/6 mice were exposed to benzene at varying concentrations of 60, 150, or 300 mg/kg/d for 15 d. Mice in the benzene groups displayed weight loss, and hematologic consequences including decreased red and white blood cell counts, reduced platelet count, diminished hemoglobin content, and lower number of hematopoietic stem cells in bone marrow (BM)...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/26932203/dexmedetomidine-postconditioning-reduces-brain-injury-after-brain-hypoxia-ischemia-in-neonatal-rats
#12
Xiaoyan Ren, Hong Ma, Zhiyi Zuo
Perinatal asphyxia can lead to death and severe disability. Brain hypoxia-ischemia (HI) injury is the major pathophysiology contributing to death and severe disability after perinatal asphyxia. Here, seven-day old Sprague-Dawley rats were subjected to left brain HI. Dexmedetomidine was given intraperitoneally after the brain HI. Yohimbine or atipamezole, two α2 adrenergic receptor antagonists, were given 10 min before the dexmedetomidine injection. Neurological outcome was evaluated 7 or 28 days after the brain HI...
June 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/26891273/%C3%AE-adrenergic-signaling-in-rat-heart-is-similarly-affected-by-continuous-and-intermittent-normobaric-hypoxia
#13
Klara Hahnova, Dita Kasparova, Jitka Zurmanova, Jan Neckar, Frantisek Kolar, Jiri Novotny
Chronic hypoxia may produce a cardioprotective phenotype characterized by increased resistance to ischemia-reperfusion injury. Nevertheless, the molecular basis of cardioprotective effects of hypoxia is still not quite clear. The present study investigated the consequences of a 3-week adaptation to cardioprotective (CNH, continuous normobaric hypoxia) and nonprotective (INH, intermittent normobaric hypoxia; 23 h/day hypoxia followed by 1 h/day reoxygenation) regimen of hypoxia on β-adrenergic signaling in the rat myocardium...
April 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/26889007/tissue-specific-root-ion-profiling-reveals-essential-roles-of-the-cax-and-aca-calcium-transport-systems-in-response-to-hypoxia-in-arabidopsis
#14
Feifei Wang, Zhong-Hua Chen, Xiaohui Liu, Timothy David Colmer, Meixue Zhou, Sergey Shabala
Waterlogging is a major abiotic stress that limits the growth of plants. The crucial role of Ca(2+) as a second messenger in response to abiotic and biotic stimuli has been widely recognized in plants. However, the physiological and molecular mechanisms of Ca(2+) distribution within specific cell types in different root zones under hypoxia is poorly understood. In this work, whole-plant physiological and tissue-specific Ca(2+) changes were studied using several ACA (Ca(2+)-ATPase) and CAX (Ca(2+)/proton exchanger) knock-out Arabidopsis mutants subjected to waterlogging treatment...
June 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/26847457/transforming-growth-factor-beta-1-produced-by-vascular-smooth-muscle-cells-predicts-fibrosis-in-the-gastrocnemius-of-patients-with-peripheral-artery-disease
#15
Duy M Ha, Lauren C Carpenter, Panagiotis Koutakis, Stanley A Swanson, Zhen Zhu, Mina Hanna, Holly K DeSpiegelaere, Iraklis I Pipinos, George P Casale
BACKGROUND: Lower leg ischemia, myopathy, and limb dysfunction are distinguishing features of peripheral artery disease (PAD). The myopathy of PAD is characterized by myofiber degeneration in association with extracellular matrix expansion, and increased expression of transforming growth factor-beta 1 (TGF-β1; a pro-fibrotic cytokine). In this study, we evaluated cellular expression of TGF-β1 in gastrocnemius of control (CTRL) and PAD patients and its relationship to deposited collagen, fibroblast accumulation and limb hemodynamics...
February 4, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/26822811/nutritional-supplementation-in-patients-with-chronic-obstructive-pulmonary-disease
#16
REVIEW
Meng-Jer Hsieh, Tsung-Ming Yang, Ying-Huang Tsai
Malnutrition in patients with chronic obstructive pulmonary disease (COPD) is associated with cachexia, sarcopenia, and weight loss, and may result in poorer pulmonary function, decreased exercise capacity, and increased risk of exacerbations. Providing nutritional supplementation is an important therapeutic intervention, particularly for severely ill COPD patients with malnutrition. Higher calorie intake through nutritional supplementation significantly increases body weight and muscle strength, and improves quality of life in malnourished COPD patients...
August 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/26818215/comparison-of-hypoxia-activated-prodrug-evofosfamide-th-302-and-ifosfamide-in-preclinical-non-small-cell-lung-cancer-models
#17
Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Damien J Ferraro, Yan Wang, Don Jung, Mark D Matteucci, Charles P Hart
Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide. In hypoxic conditions Br-IPM is released and alkylates DNA. Ifosfamide is a chloro-isophosphoramide prodrug activated by hepatic Cytochrome P450 enzymes. Both compounds are used for the treatment of cancer. Ifosfamide has been approved by the FDA while evofosfamide is currently in the late stage of clinical development. The purpose of this study is to compare efficacy and safety profile of evofosfamide and ifosfamide in preclinical non-small cell lung cancer H460 xenograft models...
April 2, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/26810756/isoflurane-postconditioning-induces-concentration-and-timing-dependent-neuroprotection-partly-mediated-by-the-glur2-ampa-receptor-in-neonatal-rats-after-brain-hypoxia-ischemia
#18
Ying Xu, Hang Xue, Ping Zhao, Yating Yang, Guoyu Ji, Weiwei Yu, Guang Han, Mengmeng Ding, Feifei Wang
BACKGROUND: It has been demonstrated that preconditioning with 1.5 % isoflurane reduces hypoxia/ischemia (HI)-induced brain loss/injury in neonatal rats. Ca(2+) influx mediated by α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) is involved in HI-induced neuronal death. Here, we investigated the effective concentrations and time windows for neuroprotection by isoflurane postconditioning in neonatal rats after brain HI and determined whether GluR2-containing AMPARs mediate this neuroprotection...
June 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/26588830/sympathetic-vasoconstrictor-responsiveness-of-the-leg-vasculature-during-experimental-endotoxemia-and-hypoxia-in-humans
#19
Patrice Brassard, Morten Zaar, Pia Thaning, Niels H Secher, Jaya B Rosenmeier
OBJECTIVE: Sympathetic vasoconstriction regulates peripheral circulation and controls blood pressure, but sepsis is associated with hypotension. We evaluated whether apparent loss of sympathetic vasoconstrictor responsiveness relates to distended smooth muscles or to endotoxemia and/or hypoxia. DESIGN: Prospective descriptive study. SETTING: Hospital research laboratory. SUBJECTS: Ten healthy young men (age [mean ± SD], 31 ± 8 yr; body weight, 83 ± 10 kg) participated in the study...
April 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26475509/sickness-behavior-induced-by-cisplatin-chemotherapy-and-radiotherapy-in-a-murine-head-and-neck-cancer-model-is-associated-with-altered-mitochondrial-gene-expression
#20
Elisabeth G Vichaya, Jessica M Molkentine, Daniel W Vermeer, Adam K Walker, Rebekah Feng, Gerard Holder, Katherine Luu, Ryan M Mason, Leo Saligan, Cobi J Heijnen, Annemieke Kavelaars, Kathy A Mason, John H Lee, Robert Dantzer
The present study was undertaken to explore the possible mechanisms of the behavioral alterations that develop in response to cancer and to cancer therapy. For this purpose we used a syngeneic heterotopic mouse model of human papilloma virus (HPV)-related head and neck cancer in which cancer therapy is curative. Mice implanted or not with HPV+ tumor cells were exposed to sham treatment or a regimen of cisplatin and radiotherapy (chemoradiation). Sickness was measured by body weight loss and reduced food intake...
January 15, 2016: Behavioural Brain Research
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