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Germ cell tumours

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https://www.readbyqxmd.com/read/28216981/real-case-of-primitive-embryonal-duodenal-carcinoma-in-a-young-man
#1
Julien Barbieux, Riccardo Memeo, Vito De Blasi, Sebastian Suciu, Vanina Faucher, Gerlinde Averous, Catherine Roy, Jacques Marescaux, Didier Mutter, Patrick Pessaux
We report here the case of a young man suffering from a rare germ cell tumour. The patient was a 25-year-old man who was referred to our centre for asthenia, stinging epigastric pain, and an iron deficiency anaemia. Gastroscopy revealed a circumferential vegetating lesion on the second portion of the duodenum. The lesion was indurated at the third portion of the duodenum, responsible for a tight stenosis. A computerized tomography-scan of the chest, abdomen and pelvis, and a pancreatic MRI showed a circumferential lesion with a bi-ductal dilatation (i...
January 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28209431/corrigendum-re-serum-levels-of-microrna-mir-371a-3p-a-sensitive-and-specific-new-biomarker-for-germ-cell-tumours-eur-urol-2017-71-213-20
#2
Klaus-Peter Dieckmann, Arlo Radtke, Meike Spiekermann, Thomas Balks, Cord Matthies, Pascal Becker, Christian Ruf, Christoph Oing, Karin Oechsle, Carsten Bokemeyer, Johannes Hammel, Sebastian Melchior, Werner Wosniok, Gazanfer Belge
No abstract text is available yet for this article.
February 13, 2017: European Urology
https://www.readbyqxmd.com/read/28208952/rare-site-of-parasitic-dermoid-cyst-at-uterovesical-fold-of-peritoneum-with-absent-one-sided-adnexa
#3
Sunita Dubey, Alka Sehgal, Puneeti Ballega, Rps Punia
Teratomas are the most common type of germ cell tumour. It can be congenital or acquired and are usually found in gonads (testes and ovaries). Parasitic dermoid cysts are rare and their actual incidence is unknown. We are reporting a case of 25-year-old gravida two, para one and one living child, who underwent emergency cesarean section in view of symptomatic placenta previa. A parasitic dermoid cyst was found incidently in front of uterus which was attached to uterovasical fold of bladder. This cyst did not show any connection to uterus or adnexa...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208526/re-expression-of-micrornas-of-c19mc-in-different-histological-types-of-testicular-germ-cell-tumour
#4
Jerome P Richie
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28135773/epidemiological-study-of-paediatric-germ-cell-tumours-revealed-the-incidence-and-distribution-that-was-expected-but-a-low-mortality-rate
#5
Madeline Evers, Catherine Rechnitzer, Niels Graem, Peder Skov Wehner, Henrik Schroeder, Steen Rosthoej, Christiane Hammershaimb Mosbech, Christina Engel Hoei-Hansen, Astrid Sehested, Taryn D Treger, Jesper Brok
AIM: Germ cell tumours (GCTs) are a rare heterogeneous tumour group derived from primordial germ cells, which can be benign or malignant and occur in the gonads or extragonadally. This study mapped the paediatric GCTs in Denmark from 1984-2013 to study the incidence and outcome. METHODS: We identified paediatric GCTs from the Danish Childhood Cancer and National Pathology Registries and reviewed the case records for patient characteristics, tumour characteristics and clinical outcome...
January 30, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28130795/clinical-morphological-and-immunohistochemical-evidence-that-small-cell-carcinoma-of-the-ovary-of-hypercalcaemic-type-sccoht-may-be-a-primitive-germ-cell-neoplasm
#6
W Glenn McCluggage, Leora Witkowski, Blaise A Clarke, William D Foulkes
AIMS: The histogenesis and cell lineage of small cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) is unknown. We aim to provide evidence that this may be a primitive germ cell neoplasm arising from a teratoma. METHODS/ RESULTS: Following the identification of two cases of SCCOHT associated with germ cell tumours (one dermoid cyst, one immature teratoma with a focus of yolk sac tumour), we undertook a literature review to look for any prior reports of SCCOHT in association with other neoplasms or elements...
January 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28124497/maternal-preeclampsia-and-odds-of-childhood-cancers-in-offspring-a-california-statewide-case-control-study
#7
Xiaoqing Xu, Beate Ritz, Myles Cockburn, Christina Lombardi, Julia E Heck
BACKGROUND: Preeclampsia is a major cause of adverse effects on fetal health. We examined associations between fetal exposure to preeclampsia and subsequent odds of childhood cancers. METHODS: We obtained childhood cancer cases (n = 13 669) diagnosed at 5 years old or younger between 1988 and 2012 from the California Cancer Registry and linked them to birth certificates. Controls (n = 271 383) were randomly selected from all California births and frequency matched to cases by birth year...
March 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28120701/are-testicular-mixed-germ-cell-tumours-associated-with-hepatitis-c-hcv-in-hiv-positive-men-who-have-sex-with-men
#8
David Atefi, Nicolas Pinto-Sander, Daniel Richardson
No abstract text is available yet for this article.
February 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28107452/mice-lacking-hbp1-function-are-viable-and-fertile
#9
Cassy M Spiller, Dagmar Wilhelm, David A Jans, Josephine Bowles, Peter Koopman
Fetal germ cell development is tightly regulated by the somatic cell environment, and is characterised by cell cycle states that differ between XY and XX gonads. In the testis, gonocytes enter G1/G0 arrest from 12.5 days post coitum (dpc) in mice and maintain cell cycle arrest until after birth. Failure to correctly maintain G1/G0 arrest can result in loss of germ cells or, conversely, germ cell tumours. High mobility group box containing transcription factor 1 (HBP1) is a transcription factor that was previously identified in fetal male germ cells at the time of embryonic cell cycle arrest...
2017: PloS One
https://www.readbyqxmd.com/read/28105559/mature-cystic-teratoma-of-the-ovary-a-cutting-edge-overview-on-imaging-features
#10
REVIEW
Hilal Sahin, Samir Abdullazade, Muzaffer Sanci
Mature cystic teratoma (MCT) is the most common neoplasm of the ovary and includes at least two well- differentiated germ cell layers. Different combinations of mature tissue derivatives with varying arrangements in the tumour cause a wide spectrum of radiological presentation ranging from a purely cystic mass to a complex cystic mass with a considerable solid component. In different imaging modalities, each radiological feature reflects a specific pathologic equivalent that forms because of diverse compositions of histological components...
January 19, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28096924/scrotal-recurrence-of-germ-cell-tumour-in-a-non-violated-scrotum
#11
Jenny Li, Nicholas Power
Testicular cancer is the most common cancer diagnosis in males aged 15-30 years. For over a century, radical inguinal orchiectomy has been the standard of care for initial treatment of testicular cancer. This approach is preferred over trans-scrotal interventions, in an effort to avoid tumour seeding, spermatic cord invasion, and disturbance to lymphatic drainage. Scrotal violation is defined as any trans-scrotal intervention that may impact spread of disease in testicular cancer, including scrotal orchiectomy, fine-needle aspiration, and testicular biopsy...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28081550/ninth-grade-school-performance-in-danish-childhood-cancer-survivors
#12
Klaus Kaae Andersen, Anne Katrine Duun-Henriksen, Marie Hoffmann Frederiksen, Jeanette Falck Winther
BACKGROUND: Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS: We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Applying a matched design we compared grades of childhood cancer survivors to children without cancer at ninth grade. We estimated grade differences by subject and its correlation to cancer site and age at diagnosis...
January 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28073824/a-drosophila-toolkit-for-defining-gene-function-in-spermatogenesis
#13
Nicole A Siddall, Gary R Hime
Expression profiling and genomic sequencing methods enable the accumulation of vast quantities of data that relate to expression of genes during the maturation of male germ cells from primordial germ cells to spermatozoa, and potential mutations that underlie male infertility. However, determination of gene function in specific aspects of spermatogenesis or linking abnormal gene function with infertility remain rate limiting, as even in an era of CRISPR analysis of gene function in mammalian models, this still requires considerable resources and time...
January 10, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28044305/clinicopathological-analysis-of-mediastinal-masses-a-mixed-bag-of-non-neoplastic-and-neoplastic-etiologies
#14
Preeti Sharma, Vidya Jha, Naveen Kumar, Rohit Kumar, Ashish Mandal
OBJECTIVE: The mediastinum is the central portion of the thoracic cavity, housing numerous organs and harbouring a mixed bag of non-neoplastic and neoplastic lesions. Accurate diagnosis is essential owing to the widely variable therapeutic and prognostic implications. MATERIAL AND METHOD: Cases of mediastinal masses were retrospectively reviewed from January 2011 till January 2016. Clinico-radiological records of these cases were retrieved. Fine needle aspiration cytology (FNAC) was performed wherever feasible...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28032432/perception-of-prognosis-of-cancer-patients-by-non-oncologists
#15
Hadar Goldvaser, Yonatan Milman, Tal Dujovni, Anat Stern, Muhamad Mahamid, Ekaterina Hanovich, Amir Zivony, Tzippy Shochat, Rinat Yerushalmi, Anat Gafter-Gvili, Baruch Brenner, Daniel Shepshelovich
BACKGROUND: Data are lacking regarding the perception of cancer patients' prognosis by physicians who are not oncologists. METHODS: This was a multicenter survey of seven university-affiliated hospitals, assessing physicians' perception of the median survival of patients with seven advanced malignancies. The study cohort included physicians from all 73 internal medicine, surgery, emergency medicine and critical care departments in the participating hospitals. Family practitioners were contacted through email...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28031857/giant-mature-teratoma-in-the-mediastinum-presenting-with-rapid-growth
#16
Kohei Fujita, Kazuki Hayashi, Makoto Motoishi, Satoru Sawai, Tsuyoshi Terashima, Tadashi Mio
Teratomas are primary germ-cell tumours in the mediastinum. Although they are generally slow-growing and asymptomatic, rapid growth causing life-threatening complications can occur. Sebaceous secretion, insulin production, chorionic gonadotropin secretion and pancreatic enzyme secretion are the presumptive causes of tumour progression. Only few cases of rapidly growing teratomas have been reported previously. Here, we present a case of a giant mature teratoma in the mediastinum that presented with rapid growth and compare the characteristics of this case with those of previous cases...
December 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28026145/the-bromodomain-inhibitor-jq1-triggers-growth-arrest-and-apoptosis-in-testicular-germ-cell-tumours-in-vitro-and-in-vivo
#17
Sina Jostes, Daniel Nettersheim, Martin Fellermeyer, Simon Schneider, François Hafezi, Friedemann Honecker, Valerie Schumacher, Matthias Geyer, Glen Kristiansen, Hubert Schorle
Type II testicular germ cell cancers (TGCT) are the most frequently diagnosed tumours in young men (20-40 years) and are classified as seminoma or non-seminoma. TGCTs are commonly treated by orchiectomy and chemo- or radiotherapy. However, a subset of metastatic non-seminomas (embryonal carcinomas) displays only incomplete remission or relapse and requires novel treatment options. Recent studies have shown effective application of the small-molecule inhibitor JQ1 in tumour therapy, which interferes with the function of 'bromodomain and extraterminal (BET)' proteins...
December 27, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28009066/amniotic-fluid-stem-cells-the-known-the-unknown-and-potential-regenerative-medicine-applications
#18
Stavros P Loukogeorgakis, Paolo De Coppi
The amniotic fluid has been identified as an untapped source of cells with broad potential, which possess immunomodulatory properties and don't have the ethical and legal limitations of embryonic stem cells. CD117(c-Kit)+ cells selected from amniotic fluid have been shown to differentiate into cell lineages representing all three embryonic germ layers without generating tumours, making them ideal candidates for regenerative medicine applications. Moreover, their ability to engraft in injured organs and modulate immune and repair responses of host tissues, suggest that transplantation of such cells may be useful for the treatment of various degenerative and inflammatory diseases...
December 23, 2016: Stem Cells
https://www.readbyqxmd.com/read/27996046/rare-disruptive-mutations-in-ciliary-function-genes-contribute-to-testicular-cancer-susceptibility
#19
Kevin Litchfield, Max Levy, Darshna Dudakia, Paula Proszek, Claire Shipley, Sander Basten, Elizabeth Rapley, D Timothy Bishop, Alison Reid, Robert Huddart, Peter Broderick, David Gonzalez de Castro, Simon O'Connor, Rachel H Giles, Richard S Houlston, Clare Turnbull
Testicular germ cell tumour (TGCT) is the most common cancer in young men. Here we sought to identify risk factors for TGCT by performing whole-exome sequencing on 328 TGCT cases from 153 families, 634 sporadic TGCT cases and 1,644 controls. We search for genes that are recurrently affected by rare variants (minor allele frequency <0.01) with potentially damaging effects and evidence of segregation in families. A total of 8.7% of TGCT families carry rare disruptive mutations in the cilia-microtubule genes (CMG) as compared with 0...
December 20, 2016: Nature Communications
https://www.readbyqxmd.com/read/27993794/5th-ovarian-cancer-consensus-conference-of-the-gynecologic-cancer-intergroup-gcig-clinical-trial-design-for-rare-ovarian-tumours
#20
A F Leary, M Quinn, K Fujiwara, R L Coleman, E Kohn, T Sugiyama, R Glasspool, I Ray-Coquard, N Colombo, M Bacon, A Zeimet, A Westermann, E Gomez-Garcia, D Provencher, S Welch, W Small, D Millan, A Okamoto, G Stuart, K Ochiai
This manuscript reports the consensus statements on designing clinical trials in rare ovarian tumours reached at the 5th Ovarian Cancer Consensus Conference (OCCC) held in Tokyo, November 2015. Three important questions were identified concerning rare ovarian tumours (rare epithelial ovarian cancers (eOC), sex-cord stromal tumours (SCST) and germ cell tumours (GCT)): (1) What are the research and trial issues that are unique to rare ovarian tumours? There is a lack of randomised phase III data defining standards of care which makes it difficult to define control arms, but identifies unmet needs that merit investigation...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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