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Massimo Valerio, Louise Dickinson, Afia Ali, Navin Ramachadran, Ian Donaldson, Neil Mccartan, Alex Freeman, Hashim U Ahmed, Mark Emberton
PURPOSE: Irreversible electroporation (IRE) has attractive attributes for focal ablation, namely non-thermal effect, precise demarcation of treatment, and tissue-selectivity. We report on a prospective development study investigating focal IRE. MATERIALS AND METHODS: 20 men with the following characteristics were recruited: anterior MR-visible index lesion concordant with transperineal targeted and template prostate mapping biopsy, absence of clinically significant disease elsewhere (UCL definition 2), and PSA </= 15 ng/ml...
September 30, 2016: Journal of Urology
Athanasios Petrou, Demetrios Moris, Patrick Paul Tabet, Brian David Wensley Richards, Georgios Kourounis
Pancreatic ductal adenocarcinoma is a lethal and late presenting malignancy with dismal survival rates. An estimated total of 330,000 people died from this malignancy in 2012. Although there have been improvements in diagnostic and treatment methods, the survival of late stage pancreatic cancer has not shown significant improvement in the past 4 decades. Multiple treatment approaches are available including chemotherapy, radiotherapy, and immunotherapy, but to this day surgical resection remains the only curative treatment option...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Johann J Wendler, Katharina Fischbach, Jens Ricke, Julian Jürgens, Frank Fischbach, Jens Köllermann, Markus Porsch, Daniel Baumunk, Martin Schostak, Uwe-Bernd Liehr, Maciej Pech
BACKGROUND: Irreversible electroporation (IRE) as newer ablation modality has been introduced and its clinical niche is under investigation. At present just one IRE system has been approved for clinical use and is currently commercially available (NanoKnife® system). In 2014, the International Working Group on Image-Guided Tumor Ablation updated the recommendation about standardization of terms and reporting criteria for image-guided tumor ablation. The IRE method is not covered in detail...
2016: Polish Journal of Radiology
Wanfeng Shang, Haojian Lu, Wenfeng Wan, Toshio Fukuda, Yajing Shen
Cell cutting is a significant task in biology study, but the highly productive non-embedded cell cutting is still a big challenge for current techniques. This paper proposes a vision-based nano robotic system and then realizes automatic non-embedded cell cutting with this system. First, the nano robotic system is developed and integrated with a nanoknife inside an environmental scanning electron microscopy (ESEM). Then, the positions of the nanoknife and the single cell are recognized, and the distance between them is calculated dynamically based on image processing...
2016: Scientific Reports
L Lambert, J Horejs, Z Krska, D Hoskovec, L Petruzelka, T Krechler, P Kriz, J Briza
The aim of this study was to evaluate the safety of irreversible electroporation (IRE) and the outcome of patients undergoing IRE of locally advanced pancreatic cancer (PC). Twenty-one patients with unresectable PC underwent open (n=19) or percutaneous (n=2) IRE of the tumor using the Nanoknife system with two electrodes that were repositioned several times to affect the whole mass. The size of the tumor was 39±10mm with a range from 21 to 65mm. Five patients underwent neoadjuvant chemotherapy and seven patients were treated with chemotherapy after IRE...
2016: Neoplasma
Johann Jakob Wendler, Jens Ricke, Maciej Pech, Frank Fischbach, Julian Jürgens, Sandra Siedentopf, Albert Roessner, Markus Porsch, Daniel Baumunk, Martin Schostak, Jens Köllermann, Uwe-Bernd Liehr
INTRODUCTION: It is postulated that focal IRE affords complete ablation of soft-tissue tumours while protecting the healthy peritumoral tissue. Therefore, IRE may be an interesting option for minimally invasive, kidney-tissue-sparing, non-thermal ablation of renal tumours. AIM: With this current pilot study ("IRENE trial"), we present the first detailed histopathological data of IRE of human RCC followed by delayed tumour resection. The aim of this interim analysis of the first three patients was to investigate the ablation efficiency of percutaneous image-guided focal IRE in RCC, to assess whether a complete ablation of T1a RCC and tissue preservation with the NanoKnife system is possible and to decide whether the ablation parameters need to be altered...
February 2016: Cardiovascular and Interventional Radiology
John H Rossmeisl, Paulo A Garcia, Theresa E Pancotto, John L Robertson, Natalia Henao-Guerrero, Robert E Neal, Thomas L Ellis, Rafael V Davalos
OBJECT: Irreversible electroporation (IRE) is a novel nonthermal ablation technique that has been used for the treatment of solid cancers. However, it has not been evaluated for use in brain tumors. Here, the authors report on the safety and feasibility of using the NanoKnife IRE system for the treatment of spontaneous intracranial gliomas in dogs. METHODS: Client-owned dogs with a telencephalic glioma shown on MRI were eligible. Dog-specific treatment plans were generated by using MRI-based tissue segmentation, volumetric meshing, and finite element modeling...
October 2015: Journal of Neurosurgery
J J Wendler, R Ganzer, B Hadaschik, A Blana, T Henkel, K U Köhrmann, S Machtens, A Roosen, G Salomon, L Sentker, U Witzsch, H P Schlemmer, D Baumunk, J Köllermann, M Schostak, U B Liehr
BACKGROUND: Irreversible electroporation (IRE), a new tissue ablation procedure available since 2007, could meet the requirements for ideal focal therapy (FT) with its postulated features, especially the absence of a thermal ablative effect. Thus far, there is no adequate tumor-entity-specific proof of its effectiveness, and its clinical application has hitherto been confined to very small patient cohorts. This also holds true for prostate cancer (PCA). Nevertheless, it is now being increasingly applied outside clinical trials-to a certain extent due to active advertising in the lay press...
June 2015: Der Urologe. Ausg. A
J J Wendler, M Porsch, S Nitschke, J Köllermann, S Siedentopf, M Pech, F Fischbach, J Ricke, M Schostak, U B Liehr
INTRODUCTION: Focal ablation therapy is playing an increasing role in oncology and may reduce the toxicity of current surgical treatments while achieving adequate oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue-selective with potential advantages compared with current thermal-ablation technologies or radiotherapy. The aim of this pilot trial is to determine the effectiveness and feasibility of focal percutaneous IRE in patients with localised renal cell cancer as a uro-oncological tumour model...
July 2015: Contemporary Clinical Trials
Salvatore Paiella, Giovanni Butturini, Isabella Frigerio, Roberto Salvia, Giulia Armatura, Matilde Bacchion, Martina Fontana, Mirko D'Onofrio, Enrico Martone, Claudio Bassi
PURPOSE: To evaluate the safety of the NanoKnife Low Energy Direct Current (LEDC) System (Irreversible Electroporation, IRE) in order to treat patients with unresectable pancreatic adenocarcinoma. METHODS: Prospective, nonrandomized, single-center clinical evaluation of ten patients with a cytohystological diagnosis of unresectable locally advanced pancreatic cancer (LAPC) that was no further responsive to standard treatments. The primary outcome was the rate of procedure-related abdominal complications...
2015: Digestive Surgery
Jens Ricke, Julian H W Jürgens, Frederic Deschamps, Lambros Tselikas, Katja Uhde, Ortrud Kosiek, Thierry De Baere
PURPOSE: To assess safety and efficacy of irreversible electroporation (IRE) of lung malignancies. MATERIALS AND METHODS: Patients with primary and secondary lung malignancies and preserved lung function were included in this prospective single arm trial. Primary and secondary endpoints were safety and efficacy. Recruitment goal was 36 subjects in 2 centers. Patients underwent IRE under general anesthesia with probe placement performed in Fluoroscopy-CT. The IRE system employed was NanoKnife® (Angiodynamics)...
April 2015: Cardiovascular and Interventional Radiology
Govindarajan Narayanan, Shivank Bhatia, Ana Echenique, Rekha Suthar, Katuzka Barbery, Jose Yrizarry
PURPOSE: The purpose of the study was to evaluate the effect of Irreversible Electroporation (IRE) on vessel patency in close proximity to the ablation zone. MATERIALS AND METHODS: Between January 2010 and November 2013, 101 patients underwent percutaneous IRE procedures using the NanoKnife for primary and metastatic tumors in different organs. Age ranged from 24 to 83 years. A total of 129 lesions were treated. [liver (100), pancreas (18), kidney (3), pelvis (1), aorto-caval lymph nodes (2), adrenal (2), lung (1), retroperitoneal (1), surgical bed of a prior Whipple procedure (1)]...
December 2014: Cardiovascular and Interventional Radiology
Robert E Neal, Helen Kavnoudias, Kenneth R Thomson
INTRODUCTION: Irreversible electroporation (IRE) ablation uses a series of brief electric pulses to create nanoscale defects in cell membranes, killing the cells. It has shown promise in numerous soft-tissue tumor applications. Larger voltages between electrodes will increase ablation volume, but exceeding electrical limits may risk damage to the patient, cause ineffective therapy delivery, or require generator restart. Monitoring electrical current for these conditions in real-time enables managing these risks...
June 2015: Cardiovascular and Interventional Radiology
Massimo Valerio, Louise Dickinson, Afia Ali, Navin Ramachandran, Ian Donaldson, Alex Freeman, Hashim U Ahmed, Mark Emberton
INTRODUCTION: Focal therapy may reduce the toxicity of current radical treatments while maintaining the oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue selective and so might have favourable characteristics compared to the currently used prostate ablative technologies. The aim of this trial is to determine the adverse events, genito-urinary side effects and early histological outcomes of focal IRE in men with localised prostate cancer. METHODS: This is a single centre prospective development (stage 2a) study following the IDEAL recommendations for evaluating new surgical procedures...
September 2014: Contemporary Clinical Trials
Prejesh Philips, Yan Li, Robert C G Martin
Irreversible electroporation has recently been applied to tissue and tumor ablation. This animal model was developed to evaluate optimal parameters for subcutaneous tumor ablation. The immortalized Panc1 tumor cell line was used for generating tumors via subcutaneous injection in mice. Under general anesthesia with complete muscle relaxation, electroporation was performed with the NanoKnife device. Post-procedure tumors were recovered and studied at specified time intervals to assess the efficacy.
2014: Methods in Molecular Biology
Zhuoli Zhang, Weiguo Li, Daniel Procissi, Patrick Tyler, Reed A Omary, Andrew C Larson
AIM: NanoKnife(®) (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within the cell membrane in targeted tissues. The purpose of this study was to elucidate morphological alterations following 30 min of IRE ablation in a mouse model of pancreatic cancer. MATERIALS & METHODS: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after IRE ablation...
2014: Nanomedicine
Václav Janík, Dana Skrabalová, Robert Gürlich, Jiří Málek
BACKGROUND: Irreversible electroporation (IRE) is a new method of local therapy of malign tumours based on bioelectric effect of electrical current. Short electric pulses with high voltage create nano size-pores in tumour cell membranes resulting in apoptosis of the exposed cells. The purpose of our study was to verify the IRE technique performed percutaneously under CT navigation and to assess effects of application of this method in early stages of primary and secondary hepatic, pancreatic, renal and pulmonary tumours...
2013: Casopís Lékar̆ů C̆eských
J Fanta, P Horák, J Marvan, M Mašek, M Kašpar, N Pauk, J Dvořák
We have used the method of irreversible electroporation (IRE) twice to treat central non-small cell lung tumours. Both tumours obstructed the right main stem bronchus. Due to a high risk of right-sided pneumonectomy we chose to apply the tissue sparing device called NanoKnife and an alternative IRE method. The first surgery was performed in August 2011 and the second one in June 2012. The first case was an epidermoid carcinoma, 3 cm in size, which completely obstructed the right main stem bronchus on the boundary line with the upper lobar bronchus and caused lung atelectasis...
November 2012: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Yajing Shen, Masahiro Nakajima, Zhan Yang, Seiji Kojima, Michio Homma, Toshio Fukuda
A novel nanoknife with a buffering beam is proposed for single-cell cutting. The nanoknife was fabricated from a commercial atomic force microscopy (AFM) cantilever by focused-ion-beam (FIB) etching technique. The material identification of the nanoknife was determined using the energy dispersion spectrometry (EDS) method. It demonstrated that the gallium ion pollution of the nanoknife can be ignored during the etching processes. The buffering beam was used to measure the cutting force based on its deformation...
July 29, 2011: Nanotechnology
X L Wei, A N Jiang, S Gao, Q Chen
Through nanomanipulation inside scanning electron microscope, a carbon nanotube scanning probe microscope tip was made by connecting a carbon nanotube with a silicon atomic force microscope tip. The carbon nanotube scanning probe microscope tip was then tailored to the desired length and end structure by a "nanoknife" which is a carbon nanotube adhered to a metal tip. Through mapping the same carbon nanotube on SiO2 substrate, it was found that the lateral resolution of the carbon nanotube tips can be improved significantly through sharpening the tip ends, and the sharpened carbon nanotube tips had better performance than commercial silicon tips...
February 2009: Journal of Nanoscience and Nanotechnology
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