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Abdominal Injury

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https://www.readbyqxmd.com/read/29774544/functional-molecules-in-mesothelial-to-mesenchymal-transition-revealed-by-transcriptome-analyses
#1
Sara Namvar, Adrian S Woolf, Leo A H Zeef, Thomas Wilm, Bettina Wilm, Sarah E Herrick
Peritoneal fibrosis is a common complication of abdominal and pelvic surgery, and can also be triggered by peritoneal dialysis, resulting in treatment failure. In these settings, fibrosis is driven by activated myofibroblasts that are considered to be partly derived by mesothelial-to-mesenchymal transition (MMT). We hypothesised that if the molecular signature of MMT could be better defined, these insights could be exploited to block this pathological cellular transition. Rat peritoneal mesothelial cells were purified, using an antibody to HBME1, a protein present on mesothelial cell microvilli, and streptavidin nanobead technology...
May 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29774196/common-carotid-artery-dissection-in-multiple-extracranial-injury-a-case-report
#2
Jin Sang Kil, Mi Kyung Lee, Ki Seong Eom
Traumatic common carotid artery dissection (CCAD) is rare. To our knowledge, only 14 case reports have described traumatic CCAD previously. Here, we report a case of CCAD in a patient with severe trauma. A 50-year-old man was lying on the road after drinking alcohol when a car drove over him. Computed tomography (CT) revealed multiple rib fractures with hemopneumothorax, lung contusion, flail chest, large amount of hematoma with bladder rupture, and fractures on the C6 spinous process, sacral ala, iliac bone, and pubic ramus...
April 2018: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29771705/the-causality-nexus-between-the-tako-tsubo-syndrome-and-an-assault-a-forensic-case-report
#3
Malek Zribi, Syrine Azza Manoubi, Narjes Karray, Salma Charfeddine, Wiem Benamar, Zouhir Hammami, Samir Kammoun, Samir Maatoug
"Tako-tsubo" cardiomyopathy, also known as "broken heart syndrome," is one of the rarest types of stress-induced cardiomyopathy. It frequently mimics acute coronary syndrome, characterized by transient left ventricular dysfunction, electrocardiographic changes, and release of myocardial enzymes. After treatment, the patients are cured in most cases without sequelae. Tako-tsubo syndrome is rarely considered as a reason for consultation in the forensic department.Herein, we report a case of a 68-year-old woman who was assaulted by her police officer neighbor...
May 4, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29766931/-in-vitro-differentiation-of-neural-cells-from-human-adipose-tissue-derived-stromal-cells
#4
Shruti D Dave, Chetan N Patel, Aruna V Vanikar, Hargovind L Trivedi
Background: Stem cells, including neural stem cells (NSCs), are endowed with self-renewal capability and hence hold great opportunity for the institution of replacement/protective therapy. We propose a method for in vitro generation of stromal cells from human adipose tissue and their differentiation into neural cells. Materials and Methods: Ten grams of donor adipose tissue was surgically resected from the abdominal wall of the human donor after the participants' informed consents...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29764574/-clinical-effect-and-mechanism-of-hemoperfusion-in-treatment-of-children-with-severe-abdominal-henoch-sch%C3%A3-nlein-purpura
#5
Ying Zhu, Yang Dong, Da-Liang Xu, Jia-Yun Jiang, Lin Wu, Rui-Juan Ke, Shao-Han Fang, Yin Peng
OBJECTIVE: To study the clinical effect and mechanism of hemoperfusion (HP) in the treatment of children with severe abdominal Henoch-Schönlein purpura (HSP). METHODS: A total of 24 children with severe abdominal HSP were divided into two groups: conventional treatment and HP (n=12 each). Ten healthy children who underwent physical examination were enrolled as the control group. Before and after treatment, chemiluminescence was used to measure the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α); thiobarbituric acid colorimetry was used to measure the plasma level of malondialdehyde (MDA); the hydroxylamine method was used to measure the plasma level of superoxide dismutase (SOD); chemical colorimetry was used to measure the plasma level of total anti-oxidant capability (T-AOC)...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29761278/laparoscopic-totally-extraperitoneal-tep-inguinal-hernia-repair-in-patients-with-previous-lower-abdominal-surgery
#6
Toru Zuiki, Jun Ohki, Masanori Ochi, Alan Kawarai Lefor
BACKGROUND: We have performed laparoscopic totally extraperitoneal (TEP) repair for inguinal hernia repair for the last 20 years. We use two balloon dilators (sphere and kidney type) to dissect the preperitoneal space for the TEP repair. It may be difficult to obtain exposure in patients who previously underwent lower abdominal surgery, because of adhesions to the abdominal wall. We reviewed our experience with inguinal hernia repairs to retrospectively analyze factors that limit the laparoscopic TEP approach...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29757901/revascularization-time-in-liver-transplantation-independent-prediction-of-inferior-short-and-long-term-outcomes-by-prolonged-graft-implantation
#7
Bettina M Buchholz, Undine A Gerlach, Vishnu V Chandrabalan, James Hodson, Bridget K Gunson, Hynek Mergental, Paolo Muiesan, John R Isaac, Keith J Roberts, Darius F Mirza, M Thamara Pr Perera
BACKGROUND: Strategies for successful transplantation are much needed in the era of organ shortage and there has been a resurgence of interest on the impact of revascularization time (RT) on outcomes in liver transplantation (LT). METHODS: All primary LT performed in Birmingham between 2009 and 2014 (n=678) with portal reperfusion first were stratified according to RT (<44 vs. ≥44 min) and graft quality (SLG, Donor risk index [DRI] <2.3 vs. MLG, DRI ≥2...
May 2, 2018: Transplantation
https://www.readbyqxmd.com/read/29756683/non-operative-management-of-isolated-single-abdominal-stab-wound-is-it-safe
#8
Hong Xiang Lee, Matthew Hauser, Shivangi Jog, Peter Bautz, Christopher Dobbins
BACKGROUND: This is a retrospective review of prospectively collected data on our hospital, a Level 1 trauma centre, where stable patients with single abdominal stab wounds are considered for non-operative (conservative) management if they fulfil the criteria with the aid of computed tomography. The aim is to review our current approach in managing these patients. METHODS: Patients' data were obtained from January 2005 to June 2016. All injuries classed as assault or self-harm by sharp object in Injury Severity Score body region 4 were included...
May 14, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29756107/analysis-of-89-patients-who-underwent-tube-thoracostomy-performed-by-general-surgeons
#9
Cihad Tatar, Ahmet Kocakuşak, Bahri Özer, Mehmet Celal Kızılkaya, Tamer Karşıdağ, Aziz Arı, Kenan Büyükaşık
Objective: Death due to thoracic trauma accounts for 20% of all trauma deaths. The aim of this study was to discuss the approach applied by general surgeons to thoracic trauma in our center. Material and Methods: A total of 89 patients (82 male, 7 female; mean age: 26.8 years; range: 7 to 77 years) with thoracic trauma who were admitted to the emergency department and underwent thoracostomy performed by general surgeons between January 2008 and December 2013 were retrospectively analyzed...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29756105/non-operative-management-of-abdominal-gunshot-injuries-is-it-safe-in-all-cases
#10
Nidal İflazoğlu, Orhan Üreyen, Osman Zekai Öner, Ulvi Mehmet Meral, Murat Yülüklü
Objective: In line with advances in diagnostic methods and expectation of a decrease in the number of negative laparotomies, selective non-operative management of abdominal gunshot wounds has been increasingly used over the last three decades. We aim to detect the possibility of treatment without surgery and present our experience in selected cases referred from Syria to a hospital at the Turkish-Syrian border. Material and Methods: Between February 2012 and June 2014, patients admitted with abdominal gunshot wounds were analyzed...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29753523/testicular-transposition-in-children-undergoing-brachytherapy-for-bladder-and-or-prostate-rhabdomyosarcoma
#11
Guenolee de Lambert, Cyrus Chargari, Véronique Minard-Colin, Christine Haie-Meder, Florent Guérin, Hélène Martelli
BACKGROUND/PURPOSE: Fertility preservation is a major goal in treatment of children with cancer. We describe a new technique of testicular transposition (TT) in patients treated with pulse-dose-rate (PDR) brachytherapy as part of the multimodal conservative treatment of bladder neck and/or prostate rhabdomyosarcoma (BP RMS). METHODS: Medical records of consecutive patients treated between September 2016 and August 2017 were studied. These patients underwent a TT performed during BP RMS surgery by the same suprapubic incision...
April 13, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29751180/radiographic-study-of-lumbar-sympathetic-trunk-in-the-oblique-lateral-interbody-fusion-surgery
#12
Hongli Wang, Yuxuan Zhang, Xiaosheng Ma, Xinlei Xia, Feizhou Lu, Jianyuan Jiang
BACKGROUND: Oblique lateral interbody fusion (OLIF) surgery provides a convenient and minimal access to the lesion disc with few complications, however, the left lumbar sympathetic trunk (LST) lies in the surgical field with an certain incidence of injury. The aim of this study was to describe the anatomical structures of the left LST at risk for injury during oblique lateral interbody fusion at different lumbar segment levels based on radiological evaluations. METHODS: 44 healthy young people (22 males and 22 females) were recruited and routine lumbar MR radiograph were performed...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29751089/effect-of-obesity-on-patterns-and-mechanisms-of-injury-systematic-review-and-meta-analysis
#13
REVIEW
Tarn Stroud, N M Bagnall, Philip H Pucher
BACKGROUND: Trauma is one of the major causes of morbidity and mortality globally, especially in younger populations. With an increase in obesity globally, it is important to assess the potential differences in injury pattern and management of obese patients presenting with trauma compared to lean patients to try and improve patient care. This study aims to review the available literature comparing injury patterns between obese and non-obese patients. METHODS: A systematic review of articles which assessed the association between obesity and different patterns of trauma and injury were assessed...
May 8, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29742967/restrictive-versus-liberal-fluid-therapy-for-major-abdominal-surgery
#14
Paul S Myles, Rinaldo Bellomo, Tomas Corcoran, Andrew Forbes, Philip Peyton, David Story, Chris Christophi, Kate Leslie, Shay McGuinness, Rachael Parke, Jonathan Serpell, Matthew T V Chan, Thomas Painter, Stuart McCluskey, Gary Minto, Sophie Wallace
Background Guidelines to promote the early recovery of patients undergoing major surgery recommend a restrictive intravenous-fluid strategy for abdominal surgery. However, the supporting evidence is limited, and there is concern about impaired organ perfusion. Methods In a pragmatic, international trial, we randomly assigned 3000 patients who had an increased risk of complications while undergoing major abdominal surgery to receive a restrictive or liberal intravenous-fluid regimen during and up to 24 hours after surgery...
May 9, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742223/acute-kidney-injury-and-intra-abdominal-hypertension-in-burn-patients-in-intensive-care
#15
Thalita Bento Talizin, Meiry Sayuri Tsuda, Marcos Toshiyuki Tanita, Ivanil Aparecida Moro Kauss, Josiane Festti, Cláudia Maria Dantas de Maio Carrilho, Cintia Magalhães Carvalho Grion, Lucienne Tibery Queiroz Cardoso
OBJECTIVE: To evaluate the frequency of intra-abdominal hypertension in major burn patients and its association with the occurrence of acute kidney injury. METHODS: This was a prospective cohort study of a population of burn patients hospitalized in a specialized intensive care unit. A convenience sample was taken of adult patients hospitalized in the period from 1 August 2015 to 31 October 2016. Clinical and burn data were collected, and serial intra-abdominal pressure measurements taken...
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29739826/luminal-polyethylene-glycol-alleviates-intestinal-preservation-injury-irrespective-of-molecular-size
#16
Anna Casselbrant, John Mackay Softeland, Mats Hellstrom, Mantas Malinauskas, Mihai Oltean
Intestinal preservation injury (IPI) and the resulting mucosal injury raise several serious challenges early after intestinal transplantation (ITx). The current clinical approach using only vascular perfusion allows the shortest preservation period among the abdominal organs. The experimental addition of luminal polyethylene glycol (PEG) solutions has been repeatedly suggested to alleviate preservation injury, improve graft quality and prolong the preservation time. We investigated if the size of PEG in the solution influences the development of intestinal preservation injury...
May 8, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29738748/femur-sparing-pattern-of-abnormal-fetal-growth-in-pregnant-women-from-new-york-city-after-maternal-zika-virus-infection
#17
Christie L Walker, Audrey A Merriam, Eric O Ohuma, Manjiri K Dighe, Michael Gale, Lakshmi Rajagopal, Aris T Papageorghiou, Cynthia Gyamfi-Bannerman, Kristina M Adams Waldorf
BACKGROUND: Zika virus (ZIKV) is a mosquito-transmitted flavivirus, which can induce fetal brain injury and growth restriction following maternal infection during pregnancy. Prenatal diagnosis of ZIKV-associated fetal injury in the absence of microcephaly is challenging due to an incomplete understanding of how maternal ZIKV infection affects fetal growth and the use of different sonographic reference standards around the world. We hypothesized that skeletal growth is unaffected by ZIKV infection and that the femur length can represent an internal standard to detect growth deceleration of the fetal head and/or abdomen by ultrasound...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29737475/effect-of-a-stellate-ganglion-block-on-acute-lung-injury-in-septic-rats
#18
Yong Chen, Lian Guo, Haili Lang, Xiaolan Hu, Sun Jing, Mengsi Luo, Guohai Xu, Zhidong Zhou
A stellate ganglion block (SGB) is a clinical sympathetic block which can inhibit the body systemic inflammatory response. However, whether and how SGB can attenuate the sepsis-induced acute lung injury remains unclear. Here, we evaluated the effect of SGB on sepsis-induced acute lung injury in rats. Ninety healthy Sprague Dawley (SD) male rats were divided into three groups: the sham operation group (S group), sepsis group (Sep group), and SGB group. The sepsis model rats were produced by cecum ligation and puncture (CLP), and blood samples were taken from the abdominal aorta of the rats at different time points for evaluating the concentration of TNF-α, IL-6, and IL-10 by enzyme-linked immunosorbent assay (ELISA)...
May 8, 2018: Inflammation
https://www.readbyqxmd.com/read/29736373/management-of-complex-and-redo-cases-of-pelvic-fracture-urethral-injuries
#19
Sanjay B Kulkarni, Sandesh Surana, Devang J Desai, Hazem Orabi, Subramanian Iyer, Jyotsna Kulkarni, Ajit Dumawat, Pankaj M Joshi
Objectives: Pelvic fracture urethral injuries (PFUI) result from traumatic disruption of the urethra. A significant proportion of cases are complex rendering their management challenging. We described management strategies for eight different complex PFUI scenarios. Methods: Our centre is a tertiary referral centre for complex PFUI cases. We maintain a prospective database (1995-2016), which we retrospectively analysed. All patients with PFUI managed at our institute were included...
April 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29736200/adipose-derived-mesenchymal-stem-cell-derived-exosomes-alleviate-overwhelming-systemic-inflammatory-reaction-and-organ-damage-and-improve-outcome-in-rat-sepsis-syndrome
#20
Chia-Lo Chang, Pei-Hsun Sung, Kuan-Hung Chen, Pei-Lin Shao, Chih-Chao Yang, Ben-Chung Cheng, Kun-Chen Lin, Chih-Hung Chen, Han-Tan Chai, Hsueh-Wen Chang, Hon-Kan Yip, Hong-Hwa Chen
This study tested the hypothesis that healthy adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes (HMSCEXO ) and apoptotic (A) (induced by 12 h hypoxia/12 h starvation)-ADMSC-derived exosomes (AMSCEXO ) were comparably effective at alleviating sepsis syndrome [SS; induced by cecal-ligation and puncture (CLP)]-induced systemic inflammation and reduced organ damage and unfavorable outcomes in rats. SD rats were divided into sham control (SC), SS only, SS + HMSCEXO (100 µg intravenous administration 3 h after CLP), and AMSCEXO ...
2018: American Journal of Translational Research
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