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Thoracic Injury

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https://www.readbyqxmd.com/read/29910637/combined-microwave-ablation-and-minimally-invasive-open-decompression-for-the-management-of-thoracic-metastasis-in-breast-cancer
#1
Bin Liu, Zhenchao Yuan, Chang Yuan Wei
Objective: The incidence rate of thoracic metastasis from breast cancer is increasing. Microwave ablation is one type of clinical therapy used to treat metastatic spine disease, although it can cause protein denaturation and immediate cell death, and coagulative necrosis can occur. Minimally invasive open decompression is associated with lower rates of surgical complications in comparison to traditional open surgery. Therefore, it is an alternative therapeutic option for spinal metastases...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29907082/paravertebral-dexmedetomidine-as-an-adjuvant-to-ropivacaine-protects-against-independent-lung-injury-during-one-lung-ventilation-a-preliminary-randomized-clinical-trial
#2
Wei Zhang, Shanfeng Zhang, Bing Li, Mingyang Sun, Jiaqiang Zhang
BACKGROUND: To investigate the effect of paravertebral dexmedetomidine as an adjuvant to ropivacaine on independent lung injury during one-lung ventilation. METHODS: In total, 120 patients who underwent elective radical resection of pulmonary carcinoma were randomly assigned to one of six groups (n = 20): normal saline (C group), ropivacaine (R group), intravenous dexmedetomidine (Div group), 0.5 μg/kg paravertebral dexmedetomidine as an adjuvant to ropivacaine (RD0...
June 15, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29905897/patterns-of-injury-and-outcomes-in-the-elderly-patient-with-rib-fractures-a-multicenter-observational-study
#3
Mark G Van Vledder, Vicky Kwakernaak, Tjebbe Hagenaars, Esther M M Van Lieshout, Michiel H J Verhofstad
BACKGROUND: High rates of pneumonia and death have been reported among elderly patients with rib fractures. This study aims to identify patterns of injury and risk factors for pneumonia and death in elderly patients with rib fractures. METHODS: A retrospective multicenter observational study was performed using data registered in the national trauma registry between 2008 and 2015 in the South West Netherlands Trauma region. Data regarding demographics, mechanism of injury, pulmonary and cardiovascular history, pattern of extra-thoracic and intrathoracic injuries, ICU admission, length of stay, and morbidity and mortality following admission were collected...
June 15, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29905521/contrast-enhanced-ultrasound-to-visualize-hemodynamic-changes-after-rodent-spinal-cord-injury
#4
Zin Z Khaing, Lindsay N Cates, Dane M DeWees, Alexander Hannah, Pierre Mourad, Matthew Bruce, Christoph P Hofstetter
OBJECTIVE Traumatic spinal cord injury (tSCI) causes an almost complete loss of blood flow at the site of injury (primary injury) as well as significant hypoperfusion in the penumbra of the injury. Hypoperfusion in the penumbra progresses after injury to the spinal cord and is likely to be a major contributor to progressive cell death of spinal cord tissue that was initially viable (secondary injury). Neuroprotective treatment strategies seek to limit secondary injury. Clinical monitoring of the temporal and spatial patterns of blood flow within the contused spinal cord is currently not feasible...
June 15, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29905040/-promotion-of-transplanted-collagen-scaffolds-combined-with-brain-derived-neurotrophic-factor-for-axonal-regeneration-and-motor-function-recovery-in-rats-after-transected-spinal-cord-injury
#5
Xi Chen, Yongheng Fan, Zhifeng Xiao, Xing Li, Bin Yang, Yannan Zhao, Xianglin Hou, Sufang Han, Jianwu Dai
Objective: To evaluate the effect of the combination of collagen scaffold and brain-derived neurotrophic factor (BDNF) on the repair of transected spinal cord injury in rats. Methods: Thirty-two Sprague-Dawley rats were randomly divided into 4 groups: group A (sham operation group), T 9 , T 10 segments of the spinal cord was only exposed; group B, 4-mm T 9 , T 10 segments of the spinal cord were resected; group C, 4-mm T 9 , T 10 segments of the spinal cord were resected and linear ordered collagen scaffolds (LOCS) with corresponding length was transplanted into lesion site; group D, 4-mm T 9 , T 10 segments of the spinal cord were resected and LOCS with collagen binding domain (CBD)-BDNF was transplanted into lesion site...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904191/treatment-patterns-of-in-patient-spasticity-medication-use-after-traumatic-spinal-cord-injury-a-prospective-cohort-study
#6
Kaila A Holtz, Elena Szefer, Vanessa K Noonan, Brian K Kwon, Patricia B Mills
STUDY DESIGN: Prospective cohort study using the Rick Hansen SCI Registry (RHSCIR) and retrospective medical chart review. OBJECTIVE: To describe treatment patterns of in-patient anti-spasticity medication use following traumatic spinal cord injury (SCI) in acute and rehabilitation hospital settings in British Columbia, Canada. SETTING: Quaternary trauma center, rehabilitation center. METHODS: Individuals with traumatic SCI between 2005 and 2014 enrolled in the Vancouver RHSCIR site (N = 917) were eligible for inclusion...
June 14, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29895307/kinematic-adaptions-to-induced-short-term-pelvic-limb-lameness-in-trotting-dogs
#7
Birte Goldner, Stefanie Fischer, Ingo Nolte, Nadja Schilling
BACKGROUND: Lameness due to paw injuries is common in the clinical practice. Although many studies investigated gait adaptations to diseases or injuries, mainly of the hip and knee, our understanding of the biomechanical coping mechanisms that lame dogs utilize is limited. Therefore, this study evaluated the kinematic changes associated with an induced, load-bearing pelvic limb lameness in healthy dogs trotting on a treadmill. Kinematic analysis included spatio-temporal comparisons of limb, joint and segment angles of all limbs...
June 13, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29895215/rac2-promotes-abnormal-proliferation-of-quiescent-cells-by-enhanced-junb-expression-via-the-mal-srf-pathway
#8
Hailong Pei, Ziyang Guo, Ziyang Wang, Yingchu Dai, Lijun Zheng, Lin Zhu, Jian Zhang, Wentao Hu, Jing Nie, Weidong Mao, Xianghong Jia, Bingyan Li, Tom K Hei, Guangming Zhou
Radiation-induced lung injury (RILI) occurs most often in radiotherapy of lung cancer, esophageal cancer, and other thoracic cancers. The occurrence of RILI is a complex process that includes a variety of cellular and molecular interactions, which ultimately result in carcinogenesis. However, the underlying mechanism is unknown. Here we show that Ras-related C3 botulinum toxin substrate 2 (RAC2) and transcription factor jun-B (JUNB) were upregulated in non-small cell carcinoma (NSCLC) tissues and were associated with poor prognoses for NSCLC patients...
June 13, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29890535/use-of-the-animal-trauma-triage-score-ribscore-modified-ribscore-and-other-clinical-factors-for-prognostication-in-canine-rib-fractures
#9
Daniel McCarthy, Lenore Bacek, Kyoung Kim, George Miller, Philippe Gaillard, Kendon Kuo
OBJECTIVES:  To characterize the clinical features among dogs sustaining rib fractures and to determine if age, type and severity of injury, entry blood lactate, trauma score and rib fracture score were associated with outcome. METHODS:  A retrospective study was performed to include dogs that were presented with rib fractures. Risk factors evaluation included breed, age, body weight, diagnosis, presence of a flail chest, bandage use, puncture wound presence, rib fracture number, location of the fracture along the thoracic wall, hospital stay length, body weight, other fractures, pleural effusion, pulmonary contusions, pneumothorax and occurrence of an anaesthetic event...
June 11, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29889084/phenelzine-a-small-organic-compound-mimicking-the-functions-of-cell-adhesion-molecule-l1-promotes-functional-recovery-after-mouse-spinal-cord-injury
#10
Rong Li, Sudhanshu Sahu, Melitta Schachner
BACKGROUND: Neural cell adhesion molecule L1 contributes to nervous system development and maintenance by promoting neuronal survival, neuritogenesis, axonal regrowth/sprouting, myelination, and synapse formation and plasticity. L1 also enhances recovery after spinal cord injury and ameliorates neurodegenerative processes in experimental rodent models. Aiming for clinical translation of L1 into therapy we screened for and functionally characterized in vitro the small organic molecule phenelzine, which mimics characteristic L1 functions...
June 6, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29886219/national-trends-of-thoracic-endovascular-aortic-repair-tevar-versus-open-repair-in-blunt-thoracic-aortic-injury
#11
Areg Grigorian, Dean Spencer, Carlos Donayre, Jeffry Nahmias, Sebastian Schubl, Viktor Gabriel, Cristobal Barrios
BACKGROUND: Blunt thoracic aortic injury (BTAI) occurs in <1% of all trauma admissions. Considering the advent of multiple thoracic endovascular aortic repair (TEVAR) devices over the past decade, improved outcomes of TEVAR supported in the literature, rapid diagnosis and improved preoperative planning of BTAI using computed tomography imaging, we hypothesized that the national incidence of TEVAR in BTAI has increased while open repair has decreased. In addition, we hypothesized that the mortality risk in BTAI patients undergoing TEVAR would be lower than open repair...
June 7, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29885914/successful-treatment-of-massive-hemothorax-with-class-iv-shock-using-aortography-with-transcatheter-embolization-of-actively-bleeding-posterior-left-intercostal-arteries-after-penetrating-left-chest-trauma-a-case-for-the-hybrid-or
#12
Carolyn Moore, Golda Kwayisi, Prince Esiobu, Keren A Bashan-Gilzenrat, Leslie R Matthews, Jonathan Nguyen, Nathaniel Moriarty, Michael Liggon, Kahdi Udobi, Assad Taha, Ed Childs, Omar Danner
Hemothorax is a common occurrence after blunt or penetrating injury to the chest. Posterior intercostal vessel hemorrhage as a cause of major intrathoracic bleeding is an infrequent source of massive bleeding. Selective angiography with trans-catheter embolization may provide a minimally invasive and efficient method of controlling bleeding refractory to surgical treatment. PRESENTATION OF CASE: A 19 year-old male sustained a gunshot wound to his left chest with massive hemothorax and refractory hemorrhage...
May 3, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29885740/a-nationwide-study-of-treatment-modalities-for-thoracic-aortic-injury
#13
Young-Ji Seo, Sarah E Rudasill, Yas Sanaiha, Esteban Aguayo, Katherine L Bailey, Vishal Dobaria, Peyman Benharash
BACKGROUND: Thoracic aortic injuries have traditionally been associated with high morbidity and mortality. Thoracic endovascular aortic repair has emerged as a suitable alternative to open repair, but its impact at a national level remains ill defined. This study aimed to analyze the national trends of patient characteristics, outcomes, and resource utilization in the treatment of thoracic aortic injuries. METHODS: Patients admitted with thoracic aortic injuries from 2005-2014 were identified in the National Inpatient Sample...
June 6, 2018: Surgery
https://www.readbyqxmd.com/read/29884553/analysis-of-the-etiology-and-treatment-of-chylothorax-in-119-pediatric-patients-in-a-single-clinical-center
#14
Chun Wu, Zhengxia Pan, Yuhao Wu, Quan Wang, Yonggang Li, Yong An, Hongbo Li, Gang Wang, Yi Wang, Jiangtao Dai
PURPOSE: To summarize the etiology and treatment of 119 patients with chylothorax in our hospital. METHODS: A total of 119 patients with chylothorax, divided into a neonate group, an infant group, and an older-than-1-year group, were included in our study and analyzed from January 2000 to July 2017 in the Children's Hospital of Chongqing Medical University. RESULTS: A total of 90 males and 29 females were included in our study. In the neonate group, 21 chylothorax cases were due to idiopathic factors, constituting 72...
May 18, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29883655/pediatric-coronary-artery-bypass-surgery-for-congenital-heart-disease
#15
REVIEW
Soichiro Kitamura
BACKGROUND: Pediatric coronary artery bypass surgery (PCABS) for congenital heart disease has become increasingly important in infants and children undergoing modern cardiac surgery, because of its life-saving potential in unsuccessful coronary transfer surgery. This review summarizes the current surgical role of PCABS for treating congenital heart diseases. METHODS: Databases, mainly PUBMED, were searched for relevant publications regarding coronary bypass surgery in the pediatric population, from 1970 (commencement) to March 2018...
June 5, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29880832/a-toll-like-receptor-9-antagonist-restores-below-level-glial-glutamate-transporter-expression-in-the-dorsal-horn-following-spinal-cord-injury
#16
Alexandra Pallottie, Ayomi Ratnayake, Li Ni, Cigdem Acioglu, Lun Li, Ersilia Mirabelli, Robert F Heary, Stella Elkabes
Spinal cord (SC) trauma elicits pathological changes at the primary lesion and in regions distant from the injury epicenter. Therapeutic agents that target mechanisms at the injury site are likely to exert additional effects in these remote regions. We previously reported that a toll-like receptor 9 (TLR9) antagonist, oligodeoxynucleotide 2088 (ODN 2088), improves functional deficits and modulates the milieu at the epicenter in mice sustaining a mid-thoracic contusion. The present investigations use the same paradigm to assess ODN 2088-elicited alterations in the lumbar dorsal horn (LDH), a region remote from the injury site where SCI-induced molecular alterations have been well defined...
June 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29879473/homing-of-the-stem-cells-from-the-acupoint-st-36-to-the-site-of-a-spinal-cord-injury-a-preliminary-study
#17
Sharon Jiyoon Jung, Myung Geun Kook, Sungchul Kim, Kyung-Sun Kang, Kwang-Sup Soh
Homing of stem cells (SCs) to desired targets such as injured tissues remains a lingering problem in cell-based therapeutics. Studies on the biodistribution of intravenously administered SCs have shown the inefficacy of blood vessels as the homing path because most of the injected SCs are captured in the capillary beds of the lungs. We considered an alternative administration method utilizing the acupuncture meridians or the primo vascular system (PVS). We injected SCs at the acupoint Zusanli (ST-36) below the knee of a nude mouse with a spinal cord injured at the thoracic T9-10 vertebrae...
June 4, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29876644/survival-after-emergency-department-thoracotomy-in-the-pediatric-trauma-population-a-review-of-published-data
#18
Eliza E Moskowitz, Clay Cothren Burlew, Ann M Kulungowski, Denis D Bensard
BACKGROUND/PURPOSE: The utility of EDT in the adult trauma population, using well-defined guidelines, is well established, especially for penetrating injuries. Since the introduction of these guidelines, reports on the use of EDT for pediatric trauma have been published, and these series reveal a dismal, almost universally fatal, outcome for EDT following blunt trauma in the child. This report reviews the clinical outcomes of EDT in the pediatric population. MATERIALS/METHODS: We performed a review of EDT in the pediatric population using the published data from 1980 to 2017...
June 6, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29876498/how-to-break-a-mended-heart
#19
Teresa Ojode, Joshua W Sappenfield
Thoracic trauma poses a risk of injury to the thoracic organs and great vessels, including the coronaries. We present an interesting case of occult, life-threatening coronary bypass graft injury resulting from thoracic trauma. In this case, the diagnosis and management were contingent on understanding the nature of the bypass graft, which was not apparent at the time of presentation in extremis . Ultimate hemostasis required cardiac catheterization and placement of an exclusionary stent. Though there are several case reports describing native coronary injury resulting from thoracic injury, we found a single case of thoracic trauma-associated coronary bypass graft injury, which was managed medically...
June 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29876264/age-related-diffusion-and-tractography-changes-in-typically-developing-pediatric-cervical-and-thoracic-spinal-cord
#20
Mahdi Alizadeh, Joshua Fisher, Sona Saksena, Yusra Sultan, Chris J Conklin, Devon M Middleton, Laura Krisa, Jürgen Finsterbusch, Adam E Flanders, Scott H Faro, M J Mulcahey, Feroze B Mohamed
Background and objective: Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are two techniques that can measure white matter integrity of the spinal cord. Recently, DTI indices have been shown to change with age. The purpose of this study is (a) to evaluate the maturational states of the entire pediatric spinal cord using DTI and DTT indices including fractional anisotropy (FA), mean diffusivity (MD), mean length of white matter fiber tracts and tract density and (b) to analyze the DTI and DTT parameters along the entire spinal cord as a function of spinal cord levels and age...
2018: NeuroImage: Clinical
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