keyword
MENU ▼
Read by QxMD icon Read
search

Synthetic

keyword
https://www.readbyqxmd.com/read/28823097/epitope-mapping-of-histo-blood-group-antigens-bound-to-norovirus-vlps-using-std-nmr-experiments-reveals-fine-details-of-molecular-recognition
#1
Brigitte Fiege, Mila Leuthold, Francisco Parra, Kevin P Dalton, Peter J Meloncelli, Todd L Lowary, Thomas Peters
Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be critical for the infection process. Therefore, we have determined binding epitopes of synthetic type 1 to 6 blood group A- and B-tetrasaccharides binding to GII.4 human Norovirus virus like particles (VLPs) using STD NMR experiments. So far, little information is available from crystal structure analysis studies on the interactions of the reducing-end sugars with the protruding domain (P-domain) of the viral coat protein VP1...
August 19, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28823054/recent-advances-in-synthetic-lipopeptides-as-anti-microbial-agents-designs-and-synthetic-approaches
#2
REVIEW
Jun-Jie Koh, Shuimu Lin, Roger W Beuerman, Shouping Liu
Infectious diseases impose serious public health burdens and continue to be a global public health crisis. The treatment of infections caused by multidrug-resistant pathogens is challenging because only a few viable therapeutic options are clinically available. The emergence and risk of drug-resistant superbugs and the dearth of new classes of antibiotics have drawn increasing awareness that we may return to the pre-antibiotic era. To date, lipopeptides have been received considerable attention because of the following properties: They exhibit potent antimicrobial activities against a broad spectrum of pathogens, rapid bactericidal activity and have a different antimicrobial action compared with most of the conventional antibiotics used today and very slow development of drug resistance tendency...
August 19, 2017: Amino Acids
https://www.readbyqxmd.com/read/28823016/de-novo-synthesis-of-linoleic-acid-in-multiple-collembola-species
#3
Miriama Malcicka, Joachim Ruther, Jacintha Ellers
Many ecological interactions in communities take place between consumers and the organisms they feed on. Continuous surplus of specific nutritional compounds in the diet may lead to evolutionary changes in the metabolic capacity of the consumer, leaving the biosynthesis of such compounds prone to genetic decay and render organisms auxotrophic. A nutrient that is essential to many organisms is the unsaturated fatty acid, linoleic acid (LA; 18:2n-6), which is important in the maintenance of cell membrane fluidity and as a precursor for signaling molecules...
August 19, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28822991/aquatide-activation-of-sirt1-reduces-cellular-senescence-through-a-sirt1-foxo1-autophagy-axis
#4
Chae Jin Lim, Yong-Moon Lee, Seung Goo Kang, Hyung W Lim, Kyong-Oh Shin, Se Kyoo Jeong, Yang Hoon Huh, Suin Choi, Myungho Kor, Ho Seong Seo, Byeong Deog Park, Keedon Park, Jeong Keun Ahn, Yoshikazu Uchida, Kyungho Park
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging...
August 21, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28822723/effect-of-religious-belief-on-selecting-of-graft-materials-used-in-oral-and-maxillofacial-surgery
#5
Zeynep Güngörmüş, Metin Güngörmüş
PURPOSE: Various graft materials, such as synthetic and biological products, are used routinely in maxillofacial surgery. These materials are usually derived from porcine, bovine, and human tissues; some religious beliefs forbid the dietary use of substances from certain animal sources. The aim of this study was to evaluate the effect of religious belief on selecting different graft types used in maxillofacial surgery. MATERIALS AND METHODS: In total, 203 participants were included in this survey...
July 25, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28822551/disruption-of-staphylococcus-aureus-biofilms-using-rhamnolipid-biosurfactants
#6
S S E Silva, J W P Carvalho, C P Aires, M Nitschke
Staphylococcus aureus is an important pathogen that has shown ability to establish biofilm communities that can represent a source of contamination and resistance in food processing. Rhamnolipids (RL) have attracted attention as candidates to replace synthetic surfactants, exhibiting high surface activity combined with its microbial origin, biodegradability, and low toxicity. In this work, an RL biosurfactant was evaluated regarding its ability to disrupt or remove S. aureus biofilms established on polystyrene plates using nutrient broth and skim milk as the growth media...
August 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28822486/adaptation-to-toxic-hosts-as-a-factor-in-the-evolution-of-insecticide-resistance
#7
REVIEW
Andrei Alyokhin, Yolanda H Chen
Insecticide resistance is a serious economic problem that jeopardizes sustainability of chemical control of herbivorous insects and related arthropods. It can be viewed as a specific case of adaptation to toxic chemicals, which has been driven in large part, but not exclusively, by the necessity for insect pests to tolerate defensive compounds produced by their host plants. Synthetic insecticides may simply change expression of specific sets of detoxification genes that have evolved due to ancestral associations with host plants...
June 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28822400/open-retromuscular-repair-of-parastomal-hernias-with-synthetic-mesh
#8
Lucas R Beffa, Jeremy A Warren, William S Cobb, Bryan Knoedler, Joseph A Ewing, Alfredo M Carbonell
Parastomal hernias (PHs) cause significant morbidity in patients with permanent ostomies, and several laparoscopic and open repair techniques have been described. We report our experience with open retromuscular repair of PHs using permanent synthetic mesh. A prospectively maintained database was retrospectively reviewed to identify patients undergoing PH repair. Primary outcomes are surgical site occurrence, surgical site infection (SSI), and hernia recurrence. Variables were analyzed using Pearson's χ2 test or Fisher's exact test...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822396/an-evaluation-of-parastomal-hernia-repair-using-the-americas-hernia-society-quality-collaborative
#9
Sarah S Fox, Randy Janczyk, Jeremy A Warren, Alfredo M Carbonell, Benjamin K Poulose, Michael J Rosen, William W Hope
The purpose of this review was to evaluate outcomes relating to parastomal hernia repair. Data from the Americas Hernia Society Quality Collaborative were used to identify patients undergoing parastomal hernia repair from 2013 to 2016. Parastomal hernia repairs were compared with other repairs using Pearson's test and Wilcoxon test with a P value <0.05 considered significant. Parastomal hernia repairs were performed in 311 patients. Techniques of repair include open in 85 per cent and laparoscopic in 15 per cent...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822347/screening-and-confirmation-of-steroids-and-nitroimidazoles-in-urine-blood-and-food-matrices-sample-preparation-methods-and-liquid-chromatography-tandem-mass-spectrometric-separations
#10
Ádám Tölgyesi, Enikő Barta, Andrea Simon, Thomas J McDonald, Virender K Sharma
Veterinary drugs containing synthetic anabolic steroid and nitroimidazole active agents are not allowed for their applications in livestock of the European Union (EU). This paper presents analyses of twelve selected steroids and six nitroimidazole antibiotics at low levels (1.56μg/L-4.95μg/L and 0.17μg/kg-2.14μg/kg, respectively) in body fluids and egg incurred samples. Analyses involved clean-up procedures, high performance liquid chromatography (HPLC) separation, and tandem mass spectrometric screening and confirmatory methods...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28822337/photocatalysis-of-estrone-in-water-and-wastewater-comparison-between-au-tio2-nanocomposite-and-tio2-and-degradation-by-products
#11
Kireesan Sornalingam, Andrew McDonagh, John L Zhou, Md Abu Hasan Johir, Mohammad Boshir Ahmed
Gold-modified TiO2 (Au-TiO2) photocatalysts were utilised for the degradation of estrone (E1), a major endocrine disrupting chemical in water and wastewater. Au-TiO2 catalysts were synthesised by a deposition-precipitation method with gold loadings of 0-8% (wt%). The Au-TiO2 nanocomposite exhibited superior activity compared to P25 TiO2 under UVA (λ=365nm), cool white (λ>420nm) and green (λ=523nm) light emitting diodes (LEDs), for treating 1mgl(-1) of E1. The 4wt% Au loading was found to produce the best photocatalytic activity with a rate constant of 2...
August 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822282/a-two-step-optimization-strategy-for-2nd-generation-ethanol-production-using-softwood-hemicellulosic-hydrolysate-as-fermentation-substrate
#12
Iulian-Zoltan Boboescu, Malorie Gélinas, Jean-Baptiste Beigbeder, Jean-Michel Lavoie
Ethanol production using waste biomass represents a very attractive approach. However, there are considerable challenges preventing a wide distribution of these novel technologies. Thus, a fractional-factorial screening of process variables and Saccharomyces cerevisiae yeast inoculum conditions was performed using a synthetic fermentation media. Subsequently, a response-surface methodology was developed for maximizing ethanol yields using a hemicellulosic solution generated through the chemical hydrolysis of steam treatment broth obtained from residual softwood biomass...
July 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28822247/mobile-phones-an-asset-or-a-liability-a-study-based-on-characterization-and-assessment-of-metals-in-waste-mobile-phone-components-using-leaching-tests
#13
Meenakshi Hira, Sudesh Yadav, P Morthekai, Anurag Linda, Sushil Kumar, Anupam Sharma
The prolonged use of old fashioned gadgets, especially mobile phones, is declining readily with the advancement in technology which ultimately lead to generation of e-waste. The present study investigates the concentrations of nine metals (Ba, Cd, Cr, Cu, Fe, Ni, Pb, Sn, and Zn) in various components of the mobile phones using Toxicity Characteristic Leaching Procedure (TCLP), Waste Extraction Test (WET) and Synthetic Precipitation Leaching Procedure (SPLP). The results were compared with the threshold limits for hazardous waste defined by the California Department of Toxic Substances Control (CDTSC) and United States Environmental Protection Agency (USEPA)...
August 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28822131/metabolic-engineering-of-photorespiration
#14
Martin K M Engqvist, Veronica G Maurino
The introduction of two alternative glycolate catabolic pathways in the chloroplasts of Arabidopsis thaliana rendered plants with increased biomass. To introduce these synthetic pathways, the selected genes were stepwise integrated in the nuclear genome of wild-type plants. These plants were transformed by Agrobacterium tumefaciens carrying the binary vectors using the floral dip method. Selection of transformants was conducted using different selection agents and the expression of the transgenes was confirmed by PCR and enzyme activity measurements...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28822013/biomonitoring-of-chemicals-in-biota-of-two-wetland-protected-areas-exposed-to-different-levels-of-environmental-impact-results-of-the-previeni-project
#15
Cristiana Guerranti, Guido Perra, Eva Alessi, Davide Baroni, Dante Caserta, Donatella Caserta, Augusto De Sanctis, Emiliano Leonida Fanello, Cinzia La Rocca, Michela Mariottini, Monia Renzi, Sabrina Tait, Carlo Zaghi, Alberto Mantovani, Silvano Ettore Focardi
The PREVIENI project (funded by the Ministry of Environment) investigated the exposure to endocrine disrupters in samples of human population and environmental biota in Italy. The environmental biomonitoring considered two Italian WWF Oasis, with the aim to compare the presence and effects of endocrine disruptors in organisms from two protected natural areas, respectively, upstream and downstream a chemical emission site. Chemical analysis of pollutants' tissue levels was made on tissues from earthworm, barbell, trout, and coot, selected as bioindicator organisms...
August 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28821941/rheumatologic-care-of-nursing-home-residents-with-rheumatoid-arthritis-a-comparison-of-the-year-before-and-after-nursing-home-admission
#16
Andres Luque Ramos, Katinka Albrecht, Angela Zink, Falk Hoffmann
The purpose of this study was to investigate health care for patients with rheumatoid arthritis (RA) before and after admission to nursing homes. Data of a German health insurance fund from persons with diagnostic codes of RA, aged ≥65 years, admitted to a nursing home between 2010 and 2014 and continuously insured 1 year before and after admission were used. The proportion of patients with ≥1 rheumatologist visit and ≥1 prescription of biologic or conventional synthetic disease-modifying antirheumatic drugs (bDMARDs or csDMARDs), glucocorticoids and non-steroidal anti-inflammatory drugs (NSAIDs) in the year before and after admission were calculated...
August 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28821875/convenient-and-effective-icgylation-of-magnetic-nanoparticles-for-biomedical-applications
#17
Hye Sun Park, Jongwoo Kim, Mi Young Cho, Hyunseung Lee, Sang Hwan Nam, Yung Doug Suh, Kwan Soo Hong
Nanoprobes used for biomedical applications usually require surface modifications with amphiphilic surfactants or inorganic coating materials to enhance their biocompatibility. We proposed a facile synthetic approach for the phase transfer of hydrophobic magnetic nanoparticles by the direct adherence of fluorescent probes, without any chemical modifications, for use as a magnetic resonance (MR)/near-infrared (NIR) fluorescence bimodal imaging contrast agent. Indocyanine green (ICG) was used not only as an optical component for NIR imaging, but also as a surfactant for phase transfer with no superfluous moiety: we therefore called the process "ICGylation"...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821847/overcoming-the-plasticity-of-plant-specialized-metabolism-for-selective-diterpene-production-in-yeast
#18
Codruta Ignea, Anastasia Athanasakoglou, Aggeliki Andreadelli, Maria Apostolaki, Minas Iakovides, Euripides G Stephanou, Antonios M Makris, Sotirios C Kampranis
Plants synthesize numerous specialized metabolites (also termed natural products) to mediate dynamic interactions with their surroundings. The complexity of plant specialized metabolism is the result of an inherent biosynthetic plasticity rooted in the substrate and product promiscuity of the enzymes involved. The pathway of carnosic acid-related diterpenes in rosemary and sage involves promiscuous cytochrome P450s whose combined activity results in a multitude of structurally related compounds. Some of these minor products, such as pisiferic acid and salviol, have established bioactivity, but their limited availability prevents further evaluation...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821801/experimental-study-of-rheological-properties-and-oil-displacement-efficiency-in-oilfields-for-a-synthetic-hydrophobically-modified-polymer
#19
Pengcheng Liu, Zhenbao Mu, Chao Wang, Yanling Wang
In a previous study, we developed a synthetic hydrophobically modified hydroxyethyl cellulose (HEC) using bromododecane (BD), which we denote as BD-HMHEC. In this work, we continually investigate the rheological properties and its oil displacement efficiency in PuTao well area in Daqing oilfields, China. Results show that BD-HMHEC solution has good viscosification, thermal-resistance, salt-tolerance, shear resistance, and acid/alkali resistance. The storage modulus (G') and the loose modulus (G") of the BD-HMHEC solutions increase significantly with increasing BD-HMHEC concentration, and the solution becomes viscoelastic at a sufficiently high BD-HMHEC concentration...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821607/two-plant-derived-aporphinoid-alkaloids-exert-their-antifungal-activity-by-disrupting-mitochondrial-iron-sulfur-cluster-biosynthesis
#20
Siddharth K Tripathi, Tao Xu, Qin Feng, Bharathi Avula, Xiaomin Shi, Xuewen Pan, Melanie M Mask, Scott R Baerson, Melissa R Jacob, Ranga Rao Ravu, Shabana I Khan, Xing-Cong Li, Ikhlas A Khan, Alice M Clark, Ameeta K Agarwal
Eupolauridine and liriodenine are plant-derived aporphinoid alkaloids that exhibit potent inhibitory activity against the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans However, the molecular mechanism of this antifungal activity is unknown. In this study, we show that eupolauridine 9591 (E9591), a synthetic analog of eupolauridine, and liriodenine methiodide (LMT), a methiodide salt of liriodenine, mediate their antifungal activities by disrupting mitochondrial iron-sulfur (Fe-S) cluster synthesis...
August 18, 2017: Journal of Biological Chemistry
keyword
keyword
72702
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"