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https://www.readbyqxmd.com/read/28651223/impact-of-wastewater-derived-dissolved-interfering-compounds-on-growth-enzymatic-activity-and-trace-organic-contaminant-removal-of-white-rot-fungi-a-critical-review
#1
REVIEW
Muhammad B Asif, Faisal I Hai, Jingwei Hou, William E Price, Long D Nghiem
White-rot fungi (WRF) and their ligninolytic enzymes have been investigated for the removal of a broad spectrum of trace organic contaminants (TrOCs) mostly from synthetic wastewater in lab-scale experiments. Only a few studies have reported the efficiency of such systems for the removal of TrOCs from real wastewater. Wastewater derived organic and inorganic compounds can inhibit: (i) WRF growth and their enzyme production capacity; (ii) enzymatic activity of ligninolytic enzymes; and (iii) catalytic efficiency of both WRF and enzymes...
June 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28651206/an-investigation-of-the-role-of-defect-levels-on-the-radiation-response-of-synthetic-diamond-crystals-when-used-as-sensors-for-the-detection-of-mammography-x-rays
#2
Nicholas Ade
This study evaluates the role of defects on the performances of synthetic diamond sensors on exposure to mammography X-rays. Through systematic investigations, the main cause of instability of response of examined sensors necessitating pre-irradiation was isolated and ascribed to the presence of ambient light which has the effect of emptying shallow trapping levels. The changes in response between measurements in light and dark conditions varied from 2.8 ± 1.2% to 63.0 ± 0.3%. Sensitivities between 0.4 and 6...
June 17, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28651145/polymer-structure-property-requirements-for-stereolithographic-3d-printing-of-soft-tissue-engineering-scaffolds
#3
REVIEW
Ryan J Mondschein, Akanksha Kanitkar, Christopher B Williams, Scott S Verbridge, Timothy E Long
This review highlights the synthesis, properties, and advanced applications of synthetic and natural polymers 3D printed using stereolithography for soft tissue engineering applications. Soft tissue scaffolds are of great interest due to the number of musculoskeletal, cardiovascular, and connective tissue injuries and replacements humans face each year. Accurately replacing or repairing these tissues is challenging due to the variation in size, shape, and strength of different types of soft tissue. With advancing processing techniques such as stereolithography, control of scaffold resolution down to the μm scale is achievable along with the ability to customize each fabricated scaffold to match the targeted replacement tissue...
June 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28651134/effect-of-salt-type-and-concentration-on-the-growth-and-lipid-content-of-chlorella-vulgaris-in-synthetic-saline-wastewater-for-biofuel-production
#4
Jared Church, Jae-Hoon Hwang, Keug-Tae Kim, Rebecca McLean, You-Kwan Oh, Bora Nam, Jin Chul Joo, Woo Hyoung Lee
Microalgae can offer several benefits for wastewater treatment with their ability to produce large amounts of lipids for biofuel production and the high economic value of harvested biomass for biogas and fertilizer. This study found that salt concentration (∼45gL(-1)) had more of an effect than salt type on metabolisms of Chlorella vulgaris for wastewater treatment and biofuel production. Salinity stress decreased the algal growth rate in wastewater by 0.003day(-1)permScm(-1) and slightly reduced nutrient removal rates...
June 17, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651099/brain-shift-compensation-using-intraoperative-ultrasound-and-constraint-based-biomechanical-simulation
#5
Fanny Morin, Hadrien Courtecuisse, Ingerid Reinertsen, Florian Le Lann, Olivier Palombi, Yohan Payan, Matthieu Chabanas
PURPOSE: During brain tumor surgery, planning and guidance are based on preoperative images which do not account for brain-shift. However, this deformation is a major source of error in image-guided neurosurgery and affects the accuracy of the procedure. In this paper, we present a constraint-based biomechanical simulation method to compensate for craniotomy-induced brain-shift that integrates the deformations of the blood vessels and cortical surface, using a single intraoperative ultrasound acquisition...
June 15, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28651051/molecular-precision-at-micrometer-length-scales-hierarchical-assembly-of-dna-protein-nanostructures
#6
Daniel Schiffels, Veronika A Szalai, J Alexander Liddle
Robust self-assembly across length scales is a ubiquitous feature of biological systems, but remains challenging for synthetic structures. Taking a cue from biology - where disparate molecules work together to produce large, functional assemblies - we demonstrate how to engineer microscale structures with nanoscale features: Our self-assembly approach begins by using DNA polymerase to controllably create double-stranded DNA (dsDNA) sections on a single-stranded template. The single-stranded DNA (ssDNA) sections are then folded into a mechanically flexible skeleton by the origami method...
June 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28651046/a-heparan-sulfate-microarray-reveals-that-heparan-sulfate-protein-binding-exhibit-different-ligand-requirements
#7
Chengli Zong, Andre Venot, Xiuru Li, Weigang Lu, Wenyuan Xiao, Josetti Lynn Wilkes, Catherina L Salanga, Tracy M Handel, Lianchun Wang, Margreet A Wolfert, Geert-Jan Boons
Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of physiological and disease-processes. Variations in HS epimerization and sulfation provide enormous structural diversity, which is believed to underpin protein binding and regulatory properties. The ligand requirements of HS-binding proteins have, however, been defined in only a few cases. We describe here a synthetic methodology that can rapidly provide a library of well-defined HS oligosaccharides. It is based on the use of modular disaccharides to assemble several selectively protected tetrasaccharides that were subjected to selective chemical modifications such as regioselective O- and N-sulfation and selective de-sulfation...
June 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28651036/copper-catalyzed-three-component-carboazidation-of-alkenes-with-acetonitrile-and-sodium-azide
#8
Ala Bunescu, Tu M Ha, Qian Wang, Jieping Zhu
A copper-catalyzed three-component reaction of alkenes, acetonitrile and sodium azide afforded γ-azido alkyl nitriles via formation of one C(sp3)-C(sp3) bond and one C(sp3)-N bond. The transformation allows the concomitant introduction of two highly versatile groups (-CN and -N3) across the double bond. A sequence involving a copper mediated generation of cyanomethyl radical followed by its addition to alkene and a C(sp3)-N bond formation accounted for the reaction outcome. The resulting γ-azido alkyl nitrile can be easily converted to 1,4-diamine, γ-amino nitrile, γ-azido ester and γ-lactam of significant synthetic value...
June 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28650818/sparse-geometric-representation-through-local-shape-probing
#9
Julie Digne, Sebastien Valette, Raphaelle Chaine
We propose a new shape analysis approach based on the non-local analysis of local shape variations. Our method relies on a novel description of shape variations, called Local Probing Field (LPF), which describes how a local probing operator transforms a pattern onto the shape. By carefully optimizing the position and orientation of each descriptor, we are able to capture shape similarities and gather them into a geometrically relevant dictionary over which the shape decomposes sparsely. This new representation permits to handle shapes with mixed intrinsic dimensionality (e...
June 23, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28650814/multi-label-classification-by-semi-supervised-singular-value-decomposition
#10
Liping Jing, Chenyang Shen, Liu Yang, Jian Yu, Michael K Ng
Multi-label problems arise in various domains including automatic multimedia data categorization, and have generated significant interest in computer vision and machine learning community. However, existing methods do not adequately address two key challenges: exploiting correlations between labels and making up for the lack of labeled data or even missing labeled data. In this paper, we proposed to use a semi-supervised singular value decomposition to handle these two challenges. The proposed model takes advantage of the nuclear norm regularization on the singular value decomposition to effectively capture the label correlations...
June 26, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28650702/a-case-report-of-methadone-associated-hypoglycemia-in-an-11-month-old-male
#11
Michael S Toce, Margaret A Stefater, David T Breault, Michele M Burns
BACKGROUND: Methadone is a synthetic μ-opioid receptor agonist that is used in the management of pain, neonatal abstinence withdrawal syndrome, and opioid dependence. Overdose can cause miosis, respiratory depression, and central nervous system depression. Rarely, hypoglycemia has been reported. We present the case of an 11-month-old male who developed hypoketotic, hyperinsulinemic, hypoglycemia after an acute, unintentional methadone exposure. CASE DETAILS: The patient was a previously healthy 11-month-old male who presented in respiratory failure...
June 26, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28650659/asymmetric-radical-bicyclization-of-allyl-azidoformates-via-cobalt-ii-based-metalloradical-catalysis
#12
Huiling Jiang, Kai Lang, Hongjian Lu, Lukasz Wojtas, X Peter Zhang
Cobalt(II)-based metalloradical catalysis has been successfully applied to radical bicyclization of allyl azidoformates to construct aziridine/oxazolidinone-fused bicyclic structures. The Co(II) complex of D2-symmetric chiral amidoporphyrin 3,5-Di(t)Bu-QingPhyrin has been identified as an effective metalloradical catalyst for the intramolecular radical aziridination of this type of carbonyl azides, allowing for high-yielding formation of synthetically useful chiral [3.1.0]-bicyclic aziridines with high diastereoselectivity and enantioselectivity...
June 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28650649/decoration-of-chondroitin-polysaccharide-with-threonine-synthesis-conformational-study-and-ice-recrystallization-inhibition-activity
#13
Antonio Laezza, Angela Casillo, Sandro Cosconati, Caroline I Biggs, Antonio Fabozzi, Luigi Paduano, Alfonso Iadonisi, Ettore Novellino, Matthew I Gibson, Antonio Randazzo, Maria Michela Corsaro, Emiliano Bedini
Several threonine (Thr)- and/or alanine (Ala)-rich antifreeze glycoproteins (AFGPs) and polysaccharides act in nature as ice recrystallization inhibitors. Among them, the Thr-decorated capsular polysaccharide (CPS) from the cold-adapted Colwellia psychrerythraea 34H bacterium was recently investigated for its cryoprotectant activity. A semi-synthetic mimic thereof was here prepared from microbial sourced chondroitin through a four step strategy, involving a partial protection of the chondroitin polysaccharide as a key step for gaining an unprecedented quantitative amidation of its glucuronic acid units...
June 26, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28650503/magnetically-frustrated-synthetic-end-member-mn2-po4-oh-in-the-triplite-triploidite-family
#14
Olga V Yakubovich, Larisa V Shvanskaya, Olga V Dimitrova, Olga S Volkova, Alexander N Vasiliev
The manganese end member of triplite-triploidite series of compounds, Mn2(PO4)OH, is synthesized by a hydrothermal method. Its crystal structure is refined in the space group P21/c with a = 12.411(1) Å, b = 13.323(1) Å, c = 10.014(1) Å, β = 108.16(1), V = 1573.3 Å(3), Z = 8, and R = 0.0375. Evidenced in measurements of magnetization M and specific heat Cp, Mn2(PO4)OH reaches a long range antiferromagnetic order at TN = 4.6 K. As opposed to both triplite Mn2(PO4)F and triploidite-type Co2(PO4)F, the title compound is magnetically frustrated being characterized by the ratio of Curie-Weiss temperature Θ to Néel temperature TN of about 20...
June 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28650495/syntheses-of-potent-teixobactin-analogues-against-methicillin-resistant-staphylococcus-aureus-mrsa-through-the-replacement-of-l-allo-enduracididine-with-its-isosteres
#15
Anish Parmar, Abhishek Iyer, Daniel G Lloyd, Charlotte S Vincent, Stephen H Prior, Annemieke Madder, Edward J Taylor, Ishwar Singh
The recently discovered cyclic depsipeptide, teixobactin, is a highly potent antibiotic against multi-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and Mycobaterium tuberculosis. It comprises of 4 D amino acids and a rare l-allo-enduracididine amino acid. The synthesis of a properly protected l-allo-enduracididine amino acid and its incorporation into teixobactin is time consuming, synthetically challenging and low yielding and is therefore a major bottleneck in the development of potent analogues of teixobactin...
June 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28650492/exploiting-the-biosynthetic-machinery-of-streptomyces-pilosus-to-engineer-a-water-soluble-zirconium-iv-chelator
#16
Tomas Richardson-Sanchez, William Tieu, Michael P Gotsbacher, Thomas J Telfer, Rachel Codd
The water solubility of a natural product-inspired octadentate hydroxamic acid chelator designed to coordinate Zr(iv)-89 has been improved by using a combined microbiological-chemical approach to engineer four ether oxygen atoms into the main-chain region of a methylene-containing analogue. First, an analogue of the trimeric hydroxamic acid desferrioxamine B (DFOB) that contained three main-chain ether oxygen atoms (DFOB-O3) was generated from cultures of the native DFOB-producer Streptomyces pilosus supplemented with oxybis(ethanamine) (OBEA), which competed against the native 1,5-diaminopentane (DP) substrate during DFOB assembly...
June 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28650326/to-evaluate-the-efficacy-and-safety-of-cofnovex-plus-ema-syrup
#17
Zubair Ali, Muhammad Daniyal, Muhammad Khalid Adhia, Anees Alam, Babar Sarfaraz, Abdul Sattar, Khan Usmanghani
The cough and cold are very widespread conditions and a common purpose for advice in general practice. Utmost often the sign and symptoms of cough are produced by acute viral airway infection and the course is frequently benign. But it can be converted into bacterial super-infection and can cause acute bronchitis. Herbal medicines are used to treat symptoms of the cough and cold, and among these medicines Ivy leaf is used to treat mucous discharge and irritation in throat due to the cough and cold. In addition to synthetic substances such as acetylcysteine, carbocisteins, ambroxol and bromhexine, herbal medicines contain saponins, which are used in these indications...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28650175/bioactive-peptide-natural-products-as-lead-structures-for-medicinal-use
#18
Tam Dang, Roderich D Süssmuth
The need for new drugs for the treatment of various diseases is enormous. From the previous century until the present, numerous peptide and peptide-derived natural products have been isolated from bacteria and fungi. Hence, microorganisms play a pivotal role as sources for novel drugs with an emphasis on anti-infective agents. Various disciplines from biology, chemistry, and medicine are involved in early stages of the search for peptide natural products including taxonomy, microbiology, bioanalytics, bioinformatics, and medicinal chemistry...
June 26, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28650143/coupled-carbonization-strategy-towards-advanced-hard-carbon-for-high-energy-sodium-ion-battery
#19
Huimin Zhang, Hai Ming, Wenfeng Zhang, Gaoping Cao, Yusheng Yang
Sodium-ion batteries (SIBs) are expected to be a promising commercial alternative to lithium-ion batteries for grid electricity storage due to their potential low cost in the near future. Up to the present, the anode material still remains a great challenge for the application of SIBs, especially at room temperature. The graphite has an obvious limitation to store larger radius sodium ions (Na+) in comparison with lithium ions (Li+), while the hard carbon with large interlayer distance can demonstrate a relatively high storage capability and durable cycle life...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28650116/polymeric-drug-delivery-systems-for-intraoral-site-specific-chemoprevention-of-oral-cancer
#20
REVIEW
Kashappa Goud H Desai
Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery...
June 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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