keyword
MENU ▼
Read by QxMD icon Read
search

Synthetic

keyword
https://www.readbyqxmd.com/read/29031215/comprehensive-multipathway-risk-assessment-of-chemicals-associated-with-recycled-crumb-rubber-in-synthetic-turf-fields
#1
Michael K Peterson, Julie C Lemay, Sara Pacheco Shubin, Robyn L Prueitt
BACKGROUND: Thousands of synthetic turf fields in the US are regularly used by millions of individuals (particularly children and adolescents). Although many safety assessments have concluded that there are low or negligible risks related to exposure to chemicals found in the recycled rubber used to make these fields, concerns remain about the safety of this product. Existing studies of recycled rubber's potential health risks have limitations such as small sample sizes and limited evaluation of relevant exposure pathways and scenarios...
October 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29031199/artesunate-attenuates-aclt-induced-osteoarthritis-by-suppressing-osteoclastogenesis-and-aberrant-angiogenesis
#2
Chengjin Zhao, Qingbai Liu, Kunzheng Wang
Artesunate (ART) is a semi-synthetic derivative of artemisinin and used preferentially in treatment of malaria in China. ART has strong anti-inflammatory, anti-tumor, and anti-angiogenic properties. Although the pharmacological effect of ART in osteoarthritis (OA) is unknown, evidence suggests that ART might regulate osteoclastogenesis through NF-κB signaling. In this study we explored the therapeutic effect of ART in an anterior cruciate ligament transection (ACLT)-induced OA model. We found that ART effectively relieved ACLT-induced osteoarthritis, as demonstrated by the improvement expression of pathological genes...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031145/small-molecule-mediated-upregulation-of-ccr7-ameliorates-murine-experimental-autoimmune-encephalomyelitis-by-accelerating-t-cell-homing
#3
Xin Li, Tingting Lu, Wenwen Xue, Yixuan Wang, Qiong Luo, Huiming Ge, Renxiang Tan, Yan Shen, Qiang Xu
Impairing the infiltration of immune cells into the CNS is a promising target for suppressing the development of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Here, we found that oral administration of a synthetic small molecular compound Fc24 showed potential preventive effects on the development of EAE, including the reduction in EAE severity and a delay in the onset of the disease. Fc24 facilitated the accumulation of both CD4(+) and CD8(+) T cells within spleen and lymph nodes, while having no effect on MOG-specific T cell responses...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29031109/application-of-novel-ternary-deep-eutectic-solvents-as-a-functional-monomer-in-molecularly-imprinted-polymers-for-purification-of-levofloxacin
#4
Xiaoxia Li, Kyung Ho Row
A series of ecofriendly ternary deep eutectic solvents (DESs) with different molar ratios were prepared as candidate functional monomers. Three of the optimal ternary DESs as functional monomers were applied to the preparation of molecularly imprinted polymers (MIPs). After synthesis, the proposed polymers were characterized by elemental analysis (EA), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Brunauer-Emmett-Teller surface area measurements (BET) and Fourier transform infrared spectroscopy (FT-IR)...
October 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29029316/the-need-for-and-the-role-of-the-toxicological-chemist-in-the-design-of-safer-chemicals
#5
Stephen C DeVito
During the past several decades there has been an ever increasing emphasis for designers of new commercial (non-pharmaceutical) chemicals to include considerations of the potential impacts a planned chemical may have on human health and the environment as part of the design of the chemical, and to design chemicals such that they possess the desired use efficacy while minimizing threats to human health and the environment. Achievement of this goal would be facilitated by the availability of individuals specifically and formally trained to design such chemicals...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029308/difficult-to-treat-rheumatoid-arthritis-an-area-of-unmet-clinical-need
#6
Maria J H de Hair, Johannes W G Jacobs, Jan L M Schoneveld, Jacob M van Laar
Increased effectiveness of pharmacological treatments in early RA has led many to believe that difficult-to-treat, established RA is a condition of the past. However, there are still plenty of RA patients who continue to have signs and symptoms suggestive of inflammatory disease activity, despite consecutive treatment with multiple conventional synthetic and biological DMARDs. We argue that difficult-to-treat RA constitutes an area of unmet clinical need and propose a definition of this concept. An overview of what is known about the multiple contributory factors varying for each individual patient, and an approach towards improved patient-tailored management are presented...
October 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029265/preclinical-testing-of-a-broad-spectrum-antimicrobial-endotracheal-tube-coated-with-an-innate-immune-synthetic-mimic
#7
Marjan M Hashemi, John Rovig, Jordan Bateman, Brett S Holden, Tomasz Modelzelewski, Iliana Gueorguieva, Martin von Dyck, Ronald Bracken, Carl Genberg, Shenglou Deng, Paul B Savage
Background: Endotracheal tubes provide an abiotic surface on which bacteria and fungi form biofilms, and the release of endotoxins and planktonic organisms can cause damaging inflammation and infections. Objectives: Ceragenins are small molecule mimics of antimicrobial peptides with broad-spectrum antibacterial and antifungal activity, and a ceragenin may be used to provide antimicrobial protection to the abiotic surface of an endotracheal tube. Methods: A hydrogel film, containing CSA-131, was generated on endotracheal tubes...
October 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029183/evaluation-of-the-constituents-of-vetiver-oil-against-anopheles-minimus-diptera-culicidae-a-malaria-vector-in-thailand
#8
Rungarun Tisgratog, Chutipong Sukkanon, John P Grieco, Unchalee Sanguanpong, Kamlesh R Chauhan, Joel R Coats, Theeraphap Chareonviriyaphap
The development of resistance by mosquitoes to current synthetic compounds has resulted in reduced effectiveness of prevention and control methods worldwide. An alternative nonchemical based control tools are needed to be evaluated particularly plant-derived essential oils. Several components of vetiver oil have been documented as insect repellents. However, detailed knowledge of those components action against insect remains unknown. In this study, behavioral response of Anopheles minimus to four constituents of vetiver oil (valencene, terpinen-4-ol, isolongifolene, vetiverol) was evaluated by using the high-throughput screening assay system...
October 6, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029158/genetic-interaction-network-as-an-important-determinant-of-gene-order-in-genome-evolution
#9
Yu-Fei Yang, Wenqing Cao, Shaohuan Wu, Wenfeng Qian
Although it is generally accepted that eukaryotic gene order is not random, the basic principles of gene arrangement on a chromosome remain poorly understood. Here, we extended existing population genetics theories that were based on two-locus models and proposed a hypothesis that genetic interaction networks drive the evolution of eukaryotic gene order. We predicted that genes with positive epistasis would move toward each other in evolution, during which a negative correlation between epistasis and gene distance formed...
October 3, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29029151/combined-toxicity-of-three-essential-oils-against-aedes-aegypti-diptera-culicidae-larvae
#10
Ephantus J Muturi, Jose L Ramirez, Kenneth M Doll, Michael J Bowman
Essential oils are potential alternatives to synthetic insecticides because they have low mammalian toxicity, degrade rapidly in the environment, and possess complex mixtures of bioactive constituents with multi-modal activity against the target insect populations. Twenty-one essential oils were initially screened for their toxicity against Aedes aegypti (L.) larvae and three out of the seven most toxic essential oils (Manuka, oregano, and clove bud essential oils) were examined for their chemical composition and combined toxicity against Ae...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29028991/a-bayesian-procedure-for-estimating-the-causal-effects-of-nursing-home-bed-hold-policy
#11
Roee Gutman, Orna Intrator, Tony Lancaster
Nursing home bed-hold policies provide continuity of care for Medicaid beneficiaries by paying nursing homes to reserve beds so residents can return to their facility of occupancy following an acute hospitalization. In 2001, Michigan implemented bed-hold policies in nursing homes. We investigated the impact of these policies on mortality and hospitalizations using 1999-2004 quarterly data from nursing homes in Michigan and nursing homes in 11 states that did not implement such policies. Synthetic Control has been used to estimate the effects of policies by accounting for changes over time unrelated to the intervention...
October 3, 2017: Biostatistics
https://www.readbyqxmd.com/read/29028988/quasar-mpra-accurate-allele-specific-analysis-for-massively-parallel-reporter-assays
#12
Cynthia A Kalita, Gregory A Moyerbrailean, Christopher Brown, Xiaoquan Wen, Francesca Luca, Roger Pique-Regi
Motivation: The majority of the human genome is composed of non-coding regions containing regulatory elements such as enhancers, which are crucial for controlling gene expression. Many variants associated with complex traits are in these regions, and may disrupt gene regulatory sequences. Consequently, it is important to not only identify true enhancers but also to test if a variant within an enhancer affects gene regulation. Recently, allele-specific analysis in high-throughput reporter assays, such as massively parallel reporter assays (MPRA), have been used to functionally validate non-coding variants...
September 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028984/a-bayesian-framework-for-the-inference-of-gene-regulatory-networks-from-time-and-pseudo-time-series-data
#13
M Sanchez-Castillo, D Blanco, I M Tienda-Luna, M C Carrion, Yufei Huang
Motivation: Molecular profiling techniques have evolved to single-cell assays, where dense molecular profiles are screened simultaneously for each cell in a population. High-throughput single-cell experiments from a heterogeneous population of cells can be experimentally and computationally sorted as a sequence of samples pseudo-temporally ordered samples. The analysis of these data sets, comprising a large number of samples, has the potential to uncover the dynamics of the underlying regulatory programmes...
September 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028961/towards-unified-quality-verification-of-synthetic-count-data-with-countsimqc
#14
Charlotte Soneson, Mark D Robinson
Summary: Statistical tools for biological data analysis are often evaluated using synthetic data, designed to mimic the features of a specific type of experimental data. The generalizability of such evaluations depends on how well the synthetic data reproduce the main characteristics of the experimental data, and we argue that an assessment of this similarity should accompany any synthetic data set used for method evaluation. We describe countsimQC, which provides a straightforward way to generate a stand-alone report that shows the main characteristics of (e...
October 4, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028954/1-benzyl-indole-3-carbinol-is-a-highly-potent-new-small-molecule-inhibitor-of-wnt-%C3%AE-catenin-signaling-in-melanoma-cells-that-coordinately-inhibits-cell-proliferation-and-disrupts-expression-of-microphthalmia-associated-transcription-factor-isoform-m
#15
Aishwarya Kundu, Michelle G Khouri, Sheila Aryana, Gary L Firestone
1-Benzyl-indole-3-carbinol (1-benzyl-I3C), a synthetic analogue of the crucifer derived natural phytochemical I3C, displayed significantly wider sensitivity and anti-proliferative potency in melanoma cells than the natural compound. Unlike I3C, which targets mainly oncogenic BRAF-expressing cells, 1-benzyl I3C effectively inhibited proliferation of melanoma cells with a more extensive range of mutational profiles, including those expressing wild type BRAF. In both cultured melanoma cell lines and in vivo in melanoma cell-derived tumor xenografts, 1-benzyl-I3C disrupted canonical Wnt/β-catenin signaling that resulted in the down regulation of β-catenin protein levels with a concomitant increase in levels of the β-catenin destruction complex components GSK3β and Axin...
September 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028848/the-stability-of-augmented-bone-between-two-different-membranes-used-for-guided-bone-regeneration-simultaneous-with-dental-implant-placement-in-the-esthetic-zone
#16
Sirida Arunjaroensuk, Soontra Panmekiate, Atiphan Pimkhaokham
PURPOSE: This randomized controlled clinical trial compared the stability of augmented bone between a synthetic resorbable membrane and a collagen resorbable membrane with guided bone regeneration (GBR) simultaneous with dental implant placement in the esthetic zone in terms of facial bone thickness. MATERIALS AND METHODS: A total of 60 dental implants from patients requiring implant placement with simultaneous GBR in the esthetic zone were equally allocated to the test group or control group by block randomization...
October 13, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29028804/a-recombinase-polymerase-amplification-assay-for-rapid-detection-of-crimean-congo-haemorrhagic-fever-virus-infection
#17
Laura C Bonney, Robert J Watson, Babak Afrough, Manija Mullojonova, Viktoriya Dzhuraeva, Farida Tishkova, Roger Hewson
BACKGROUND: Crimean-Congo Haemorrhagic fever Virus (CCHFV) is a rapidly emerging vector-borne pathogen and the cause of a virulent haemorrhagic fever affecting large parts of Europe, Africa, the Middle East and Asia. METHODOLOGY/PRINCIPLE FINDINGS: An isothermal recombinase polymerase amplification (RPA) assay was successfully developed for molecular detection of CCHFV. The assay showed rapid (under 10 minutes) detection of viral extracts/synthetic virus RNA of all 7 S-segment clades of CCHFV, with high target specificity...
October 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29028599/predicting-the-weathering-of-fuel-and-oil-spills-a-diffusion-limited-evaporation-model
#18
Konstantinos Kotzakoulakis, Simon C George
The majority of the evaporation models currently available in the literature for the prediction of oil spill weathering do not take into account diffusion-limited mass transport and the formation of a concentration gradient in the oil phase. The altered surface concentration of the spill caused by diffusion-limited transport leads to a slower evaporation rate compared to the predictions of diffusion-agnostic evaporation models. The model presented in this study incorporates a diffusive layer in the oil phase and predicts the diffusion-limited evaporation rate...
September 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/29028550/paternal-exposure-to-environmental-17-alpha-ethinylestradiol-concentrations-modifies-testicular-transcription-affecting-the-sperm-transcript-content-and-the-offspring-performance-in-zebrafish
#19
David G Valcarce, Elena Vuelta, Vanesa Robles, Maria Paz Herráez
The synthetic estrogen 17-α-ethinylestradiol (EE2), a major constituent in contraceptive pills, is an endocrine disrupting chemical (EDC) present in the aquatic environment at concentrations of ng/L. Developmental exposure to these low concentrations in fish can induce several disorders. Zebrafish (Danio rerio) is a perfect organism for monitoring the effects of environmental contaminants. Our hypothesis is that changes promoted by EE2 in the germ line of male adults could be transmitted to the unexposed progeny...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29028489/assessment-of-types-of-synthetic-cannabinoids-in-narcotic-cases-assessed-by-the-council-of-forensic-medicine-between-2011-2015-ankara-turkey
#20
Ersin Göl, İsmet Çok
Synthetic cannabinoids mimic the effects of cannabis and are the largest and fastest growing class of newly appearing designer drugs. Reports have revealed that various types of synthetic cannabinoids are mixed with herbal substances. The present study investigated the herbal substance cases involving synthetic cannabinoids in Ankara and nearby cities in Turkey. Data were collected from the reports of synthetic cannabinoids that were analyzed between January 01, 2011 and December 31, 2015 in the Ankara Narcotic Department of the Council of Forensic Medicine at the request of the judicial authorities...
October 4, 2017: Forensic Science International
keyword
keyword
72702
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"