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https://www.readbyqxmd.com/read/29025406/impact-of-empagliflozin-on-subclinical-left-ventricular-dysfunctions-and-on-the-mechanisms-involved-in-myocardial-disease-progression-in-type-2-diabetes-rationale-and-design-of-the-empa-heart-trial
#1
Andrea Natali, Lorenzo Nesti, Iacopo Fabiani, Enrico Calogero, Vitantonio Di Bello
BACKGROUND: Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular death and risk factors, aside from lowering plasma glucose levels. With this study we aim at determining whether the treatment with empagliflozin is associated with an improvement in LV functions in diabetic patients with asymptomatic LV dysfunction against Sitagliptin, which is presumably neutral on myocardial function...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29020403/cardiac-and-systemic-rejuvenation-after-cardiosphere-derived-cell-therapy-in-senescent-rats
#2
Lilian Grigorian-Shamagian, Weixin Liu, Soraya Fereydooni, Ryan C Middleton, Jackelyn Valle, Jae Hyung Cho, Eduardo Marbán
Aim: The aim is to assess the effects of CDCs on heart structure, function, gene expression, and systemic parameters in aged rats. Diastolic dysfunction is characteristic of aged hearts. Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however, the effects of CDCs on aging have not been evaluated. Methods and Results: We compared intra-cardiac injections of neonatal rat CDCs to vehicle (phosphate-buffered saline, PBS) in 21...
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018907/mri-sport-specific-pulley-imaging
#3
Michael N Hoff, Todd D Greenberg
OBJECTIVE: We aim to create a novel MRI methodology that employs sport-specific stress views for imaging finger pulley injuries in the evaluation of post-operative healing effectiveness. The goal is to measure the bone to tendon distance (BTD), which is the current standard for determining pulley injuries. MATERIALS AND METHODS: The athlete was imaged in a crimp-grip stressed position to emulate sport-specific biomechanics. A Gradient Echo technique was modified to maximize the signal to noise ratio and minimize distortion near the bone and tendon, simplifying the determination of the BTD...
October 10, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29017174/cardiac-remodeling-induced-by-all-trans-retinoic-acid-is-detrimental-in-normal-rats
#4
Renata A C Silva, Andréa F Gonçalves, Priscila P Dos Santos, Bruna Rafacho, Renan F T Claro, Marcos F Minicucci, Paula S Azevedo, Bertha F Polegato, Silméia G Zanati, Ana Angélica Fernandes, Sergio A R Paiva, Leonardo A M Zornoff
BACKGROUND/AIMS: This study aimed to discern whether the cardiac alterations caused by retinoic acid (RA) in normal adult rats are physiologic or pathologic. METHODS AND RESULTS: Wistar rats were assigned into four groups: control animals (C, n = 20) received a standard rat chow; animals fed a diet supplemented with 0.3 mg/kg/day all-trans-RA (AR1, n = 20); animals fed a diet supplemented with 5 mg/kg/day all-trans-RA (AR2, n = 20); and animals fed a diet supplemented with 10 mg/kg/day all-trans-RA (AR3, n = 20)...
October 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28993894/the-association-of-lumbar-intervertebral-disc-calcification-on-plain-radiographs-with-the-ute-disc-sign-on-mri
#5
Uruj Zehra, Cora Bow, Jason Pui Yin Cheung, Henry Pang, William Lu, Dino Samartzis
PURPOSE: The pathogenesis and the clinical impact of disc calcification are not well known. Utilizing ultra-short time-to-echo (UTE) magnetic resonance imaging, the UTE Disc Sign (UDS) (i.e., hypo/hyper-intense disc band) was developed and found to be more significantly related to pain and disability than the conventional T2-weighted (T2W) MRI. It has been hypothesized that the UDS may represent mineralized deposits in the disc. The following study addressed the relationship between disc calcification on plain radiographs to that of the UDS on MRI...
October 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28986062/quality-control-of-regional-wall-motion-analysis-in-stress-echo-2020
#6
Quirino Ciampi, Eugenio Picano, Marco Paterni, Clarissa Borguezan Daros, Iana Simova, José Luis de Castro E Silva Pretto, Maria Chiara Scali, Nicola Gaibazzi, Sergio Severino, Ana Djordjevic-Dikic, Jaroslaw D Kasprzak, Angela Zagatina, Albert Varga, Jorge Lowenstein, Pablo Martin Merlo, Miguel Amor, Jelena Celutkiene, Julio E Perez, Giovanni Di Salvo, Maurizio Galderisi, Fabio Mori, Marco Fabio Costantino, Laura Massa, Milica Dekleva, Daniel Quesada Chaves, Paolo Trambaiolo, Rodolfo Citro, Paolo Colonna, Fausto Rigo, Marco A R Torres, Ines Monte, Ivan Stankovic, Aleksander Neskovic, Lauro Cortigiani, Federica Re, Claudio Dodi, Antonello D'Andrea, Bruno Villari, Ayana Arystan, Michele De Nes, Clara Carpeggiani
BACKGROUND: The trial "Stress Echo (SE) 2020" evaluates novel applications of SE beyond coronary artery disease. The aim of the study was control quality and harmonize reading criteria. METHODS: One reader from 78 centers of the SE 2020 network asked for credentials to read a set of 20 SE video-clips selected by the core lab. All aspiring centers met the pre-requisite of high-volume and the years of experience in SE ranged from 5 to 31years (mean value 18years)...
October 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28972290/application-of-phase-rotation-to-stress-localization-scheme-at-3-t
#7
Osnat Volovyk, Assaf Tal
PURPOSE: Application of phase rotation to the STRESS (=STEAM+PRESS) localization scheme, to shorten echo time, minimize J-coupling dephasing and estimate B1+ inhomogeneity. STRESS (=STEAM + PRESS) simultaneously refocuses and acquires the double spin echo (SE123 ) and stimulated echo (STE- ) pathways, combining PRESS-like signal with lower chemical shift displacement as in STEAM. Phase rotation effectively separates coherence pathways, allows reduction of spoiling gradients moments leading to reduction in echo time...
October 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28944584/resource-reduction-in-pediatric-chest-pain-standardized-clinical-assessment-and-management-plan
#8
Susan F Saleeb, Sarah R McLaughlin, Dionne A Graham, Kevin G Friedman, David R Fulton
OBJECTIVE: Using a Standardized Clinical Assessment and Management Plan (SCAMP) for pediatric patients presenting to clinic with chest pain, we evaluated the cost impact associated with implementation of the care algorithm. Prior to introduction of the SCAMP, we analyzed charges for 406 patients with chest pain, seen in 2009, and predicted 21% reduction of overall charges had the SCAMP methodology been used. The SCAMP recommended an echocardiogram for history, examination, or ECG findings suggestive of a cardiac etiology for chest pain...
September 24, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28924116/transient-left-ventricular-contractile-dysfunction-during-the-treatment-of-rhabdomyolysis-a-case-report-and-literature-review
#9
Toshihiro Tsuruda, Nozomi Shinohara, Miyuki Ogata, Kazuo Kitamura, Hidenobu Ochiai
Transient left ventricular contractile dysfunction (TLVCD) is often observed as a result of stress-related cardiomyopathy; however, recent reports suggest that rhabdomyolysis and eating disorders can also induce the development of TLVCD. We report a 52-year-old malnourished man who developed acute heart failure on day 4 of treatment for rhabdomyolysis. Transthoracic echocardiogram revealed severe hypokinesis at the apical and mid-ventricular segments, except for the basal segments of the left ventricular wall, which recovered within one week...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28921787/myocardial-bridging-is-associated-with-exercise-induced-ventricular-arrhythmia-and-increases-in-qt-dispersion
#10
Makiko Nishikii-Tachibana, Vedant S Pargaonkar, Ingela Schnittger, Francois Haddad, Ian S Rogers, Jennifer A Tremmel, Paul J Wang
BACKGROUND: A myocardial bridge (MB) has been associated with ventricular arrhythmia and sudden death during exercise. QT dispersion (QTd) is a measure of abnormal repolarization and may predict ventricular arrhythmia. We investigated the frequency of ventricular arrhythmias during exercise and the QTd at rest and after exercise, in patients with an MB compared to a normal cohort. METHODS: We studied the rest and stress ECG tracings of patients with an MB suspected by focal septal buckling on exercise echocardiography (EE) (Echo-MB group, N = 510), those with an MB confirmed by another examination (MB group, N = 110), and healthy controls (Control group, N = 198)...
September 18, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28921674/decline-in-effort-capacity-with-age-echocardiographic-stress-analysis-in-the-elderly
#11
Anat Milman, Gad Keren, Yan Topilsky
BACKGROUND: The present study was designed to assess the underlying mechanism of decline in effort capacity seen with aging. METHODS: We analyzed 250 healthy senior patients (≥65 years) with an ejection fraction ≥60% who underwent a stress echocardiogram test. The seniors (aged 65-94) were divided into 3 equal age groups (groups 1, 2, and 3), and their echo characteristics at rest and peak exercise (measured and calculated) were compared. RESULTS: Diastolic function at rest declined significantly (E lateral, E septal, E/E', A) with age, while other rest parameters were similar...
September 17, 2017: Echocardiography
https://www.readbyqxmd.com/read/28893651/obstructive-sleep-apnea-is-associated-with-altered-midbrain-chemical-concentrations
#12
Paul M Macey, Manoj K Sarma, Janani P Prasad, Jennifer A Ogren, Ravi Aysola, Ronald M Harper, M Albert Thomas
Obstructive sleep apnea (OSA) is accompanied by altered structure and function in cortical, limbic, brainstem, and cerebellar regions. The midbrain is relatively unexamined, but contains many integrative nuclei which mediate physiological functions that are disrupted in OSA. We therefore assessed the chemistry of the midbrain in OSA in this exploratory study. We used a recently developed accelerated 2D magnetic resonance spectroscopy (2D-MRS) technique, compressed sensing-based 4D echo-planar J-resolved spectroscopic imaging (4D-EP-JRESI), to measure metabolites in the midbrain of 14 OSA (mean age±SD:54...
November 5, 2017: Neuroscience
https://www.readbyqxmd.com/read/28887315/inorganic-nitrate-in-angina-study-a-randomized-double-blind-placebo-controlled-trial
#13
Konstantin Schwarz, Satnam Singh, Satish K Parasuraman, Amelia Rudd, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, Melanie Madhani, John Horowitz, Dana K Dawson, Michael P Frenneaux
BACKGROUND: In this double-blind randomized placebo-controlled crossover trial, we investigated whether oral sodium nitrate, when added to existing background medication, reduces exertional ischemia in patients with angina. METHODS AND RESULTS: Seventy patients with stable angina, positive electrocardiogram treadmill test, and either angiographic or functional test evidence of significant ischemic heart disease were randomized to receive oral treatment with either placebo or sodium nitrate (600 mg; 7 mmol) for 7 to 10 days, followed by a 2-week washout period before crossing over to the other treatment (n=34 placebo-nitrate, n=36 nitrate-placebo)...
September 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28871440/triheptanoin-versus-trioctanoin-for-long-chain-fatty-acid-oxidation-disorders-a-double-blinded-randomized-controlled-trial
#14
Melanie B Gillingham, Stephen B Heitner, Julie Martin, Sarah Rose, Amy Goldstein, Areeg Hassan El-Gharbawy, Stephanie Deward, Michael R Lasarev, Jim Pollaro, James P DeLany, Luke J Burchill, Bret Goodpaster, James Shoemaker, Dietrich Matern, Cary O Harding, Jerry Vockley
BACKGROUND: Observational reports suggest that supplementation that increases citric acid cycle intermediates via anaplerosis may have therapeutic advantages over traditional medium-chain triglyceride (MCT) treatment of long-chain fatty acid oxidation disorders (LC-FAODs) but controlled trials have not been reported. The goal of our study was to compare the effects of triheptanoin (C7), an anaplerotic seven-carbon fatty acid triglyceride, to trioctanoin (C8), an eight-carbon fatty acid triglyceride, in patients with LC-FAODs...
September 4, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28870983/ischaemia-as-a-cause-of-lvot-gradient-reversal-in-hcm
#15
Camelia Demetrescu, Shelley Rahman Haley, Aigul Baltabaeva
We present the case of a previously fit 84-year-old female with long-standing systemic hypertension and the echo phenotype of hypertrophic cardiomyopathy (HCM) - asymmetrical septal hypertrophy, significant resting left ventricular (LV) outflow obstruction and mitral regurgitation (MR) secondary to systolic anterior motion (SAM) of the mitral valve. Valsalva provocation caused an increase in LVOT dynamic gradient and MR severity. The patient presented with a progressive decrease in exercise capacity along with chest pain relieved by rest or sublingual GTN...
December 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28870153/myocardial-infarction-during-anaphylaxis-in-a-young-healthy-male-with-normal-coronary-arteries-is-epinephrine-the-culprit
#16
W D Jayamali, H M M T B Herath, Aruna Kulathunga
BACKGROUND: Anaphylaxis is an acute, potentially fatal medical emergency. Myocardial injury or infarction in the setting of an anaphylaxis can be due the anaphylaxis itself, when it is known as Kounis syndrome or it can also be due to the effect of epinephrine treatment. Epinephrine is considered as the cornerstone in management of anaphylaxis. Myocardial infarction secondary to therapeutic doses of adrenaline is a rare occurrence and only a few cases have been reported in literature...
September 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28865726/b-lines-with-lung-ultrasound-the-optimal-scan-technique-at%C3%A2-rest-and-during-stress
#17
Maria Chiara Scali, Angela Zagatina, Iana Simova, Nadezhda Zhuravskaya, Quirino Ciampi, Marco Paterni, Mario Marzilli, Clara Carpeggiani, Eugenio Picano
Various lung ultrasound (LUS) scanning modalities have been proposed for the detection of B-lines, also referred to as ultrasound lung comets, which are an important indication of extravascular lung water at rest and after exercise stress echo (ESE). The aim of our study was to assess the lung water spatial distribution (comet map) at rest and after ESE. We performed LUS at rest and immediately after semi-supine ESE in 135 patients (45 women, 90 men; age 62 ± 12 y, resting left ventricular ejection fraction = 41 ± 13%) with known or suspected heart failure or coronary artery disease...
November 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28845879/-a-case-of-severe-left-main-isolated-stenosis-in-a-young-woman-with-previous-history-of-non-hodgkin-lymphoma
#18
Sebastian Cinconze, Lucia Coppini, Daniela Lina, Iacopo Tadonio, Maria Alberta Cattabiani, Emilia Solinas, Luigi Vignali, Alberto Menozzi
We report the case of a 34-year-old female treated with radiotherapy and chemotherapy for non-Hodgkin lymphoma at the age of 16. The patient came to our attention because of progressive dyspnea on effort and a positive result on a pharmacologic stress echo test. Coronary angiography revealed focal critical ostial stenosis of the left main coronary artery. Considering the high surgical risk due to possible post-radiation thoracic adherence and the young patient age, she underwent successful stenting of the left main stenosis with drug-eluting stent, followed by an intravascular ultrasound-guided post-dilation and final kissing balloon inflation...
September 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28841313/decoupling-between-the-temperature-dependent-structural-relaxation-and-shear-viscosity-of-concentrated-lithium-electrolyte
#19
Tsuyoshi Yamaguchi, Koji Yoshida, Toshio Yamaguchi, Michihiro Nagao, Antonio Faraone, Shiro Seki
The intermediate scattering functions of concentrated solutions of LiPF6 in propylene carbonate (PC) were measured at various temperatures, two different wavenumbers, and three different concentrations using neutron spin echo (NSE) spectroscopy. The temperature dependence of the relaxation time was larger than that of the steady-state shear viscosity in all cases. The shear relaxation spectra were also determined at different temperatures. The normalized spectra reduced to a master curve when the frequency was multiplied by the steady-state shear viscosity, indicating that the temperature dependence of the steady-state shear viscosity can be explained by that of the relaxation time of the shear stress...
September 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28836949/2-dimensional-speckle-tracking-echocardiography-predicts-severe-coronary-artery-disease-in-women-with-normal-left-ventricular-function-a-case-control-study
#20
Ryan T Hubbard, Maria C Arciniegas Calle, Sergio Barros-Gomes, Joyce A Kukuzke, Patricia A Pellikka, Rajiv Gulati, Hector R Villarraga
BACKGROUND: Women who have coronary artery disease (CAD) often present with atypical symptoms that may lead to misdiagnosis. We assessed strain, systolic strain rate and left ventricular dyssynchrony with 2- dimensional- speckle tracking echocardiography to evaluate its use as a non-invasive method for detecting CAD in women with normal ejection fraction compared with healthy women controls with a normal angiogram. METHODS: We included 35 women with CAD confirmed by coronary angiography and a positive exercise stress echocardiography and 35 women in a control group with a low pretest probability of CAD, normal angiogram and a normal stress echocardiography with normal EF...
August 24, 2017: BMC Cardiovascular Disorders
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