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https://www.readbyqxmd.com/read/28729409/comparison-of-anatomic-and-clinical-outcomes-in-patients-undergoing-alternative-initial-noninvasive-testing-strategies-for-the-diagnosis-of-stable-coronary-artery-disease
#1
Idan Roifman, Harindra C Wijeysundera, Peter C Austin, Mohammad R Rezai, Graham A Wright, Jack V Tu
BACKGROUND: The optimal initial noninvasive diagnostic testing strategy for stable coronary artery disease (CAD) is unknown. Although American guidelines recommend an exercise stress test as the first-line test, European guidelines suggest that stress imaging (myocardial perfusion imaging or stress echocardiography) or coronary computed tomography angiography may be preferable. Understanding the relationship between the initial strategy and downstream yield of obstructive CAD and major adverse cardiac events may provide insight as to the optimal strategy...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28720027/long-term-alteration-of-the-hypothalamic-pituitary-adrenal-axis-in-children-undergoing-cardiac-surgery-in-the-first-6-months-of-life
#2
Monica McGauran, Brigid Jordan, Roseriet Beijers, Irma Janssen, Candice Franich-Ray, Carolina de Weerth, Michael Cheung
Children with congenital heart disease (CHD) have poorer neurodevelopmental and psychological outcomes. The mechanisms underlying this remain unclear. One mechanism could be that the stressful experience of cardiac surgery early in life influences long-term hypothalamic-pituitary-adrenal (HPA) axis regulation. Dysregulation of the HPA axis has been linked to poorer neurocognitive and psychological outcomes in other study populations. This case-control study aims to compare HPA-axis regulation (circadian rhythm and reactivity) using salivary cortisol in 3- to 5-year-olds with CHD who did and did not have cardiac surgery prior to 6 months of age...
July 18, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28716681/mri-magic-angle-effect-in-femorotibial-cartilages-of-the-red-kangaroo
#3
Tonima S Ali, Namal Thibbotuwawa, YuanTong Gu, Konstantin I Momot
OBJECTIVE: Kangaroo knee cartilages are robust tissues that can support knee flexion and endure high levels of compressive stress. This study aimed to develop a detailed understanding of the collagen architecture in kangaroo knee cartilages and thus obtain insights into the biophysical basis of their function. DESIGN: Cylindrical/square plugs from femoral and tibial hyaline cartilage and tibial fibrocartilage were excised from the knees of three adult red kangaroos...
July 15, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28715078/polish-stress-echocardiography-registry-pol-stress-registry-a-multicenter-study-stress-echo-in-poland-numbers-settings-results-and-complications
#4
Edyta Płońska-Gościniak, Jarosław D Kasprzak, Szymon Olędzki, Jolanta Rzucidło-Resil, Piotr Gościniak, Tomasz Kukulski, Katarzyna Mizia-Stec, Wojciech Kosmala, Dariusz Kosior, Marta Marcinkiewicz-Siemion, Barbara Brzezińska, Beata Zaborska, Marcin Fijałkowski, Iwona Świątkiewicz, Andrzej Szyszka, Jan Błażejewski, Wojciech Witkiewicz, Zbigniew Gąsior, Danuta Sorysz, Agnieszka Olszanecka
BACKGROUND: Stress echocardiography (SE) is widely used in Europe. No collective data have been available on the use of SE in Poland until now. AIM: To evaluate the number of SE investigations performed in Poland, their settings, complications and results. METHODS: In this retrospective survey, referral cardiology centers in Poland were asked to fill in a questionnaire regarding SE examinations performed from May 01, 2014 to May 01, 2015. RESULTS: The study included data from 17 university hospitals and large community hospitals which performed 4611 SE examinations, including 4408 tests in patients investigated for coronary artery disease (CAD) and 203 tests to evaluate valvular heart disease (VHD)...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28708228/clinical-and-subclinical-cardiac-late-effects-in-pediatric-hodgkin-s-lymphoma-survivors
#5
Carlo Materazzo, Maura Massimino, Elisabetta Schiavello, Marta Podda, Lorenza Gandola, Graziella Cefalo, Serena Catania, Cristina Meazza, Ivan Moschetti, Monica Terenziani
PURPOSE: Cardiac late effects are responsible for a significant burden of mortality and morbidity among pediatric Hodgkin's lymphoma (HL) survivors (HLS). The aim of our study was to assess clinical and subclinical cardiac sequelae in a cohort of childhood HLS treated in the 1980s with doxorubicin, bleomycin, vinblastine, and dacarbazine (the ABVD regimen) and limited-field radiotherapy (RT). METHODS: We retrospectively examined a series of HLS treated from 1979 to 1989...
July 8, 2017: Tumori
https://www.readbyqxmd.com/read/28701599/interesting-images-multiple-coronary-artery-aneurysms
#6
Jonathon M Howard, Omar Viswanath, Alfredo Armas, Orlando Santana, Gerald P Rosen
We present the case of a 65-year-old male who presented with stable angina and dyspnea on exertion. His initial workup yielded a positive treadmill stress test for reversible apical ischemia, and transthoracic echocardiogram demonstrated impaired systolic function. Cardiac catheterization was then performed, revealing severe atherosclerotic disease including multiple coronary artery aneurysms. As a result, the patient was advised to and subsequently underwent a coronary artery bypass graft. This case highlights the presence of multiple coronary artery aneurysms and the ability to appreciate these pathologic findings on multiple imaging modalities, including coronary angiogram, transesophageal echocardiography, and direct visualization through the surgical field...
July 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28698601/characteristics-of-sonography-in-a-rat-achilles-tendinopathy-model-possible-non-invasive-predictors-of-biomechanics
#7
Su-Ya Lee, Hsiao-Feng Chieh, Chien-Ju Lin, I-Ming Jou, Yung-Nien Sun, Li-Chieh Kuo, Po-Ting Wu, Fong-Chin Su
The purpose of this study was to investigate the dynamic changes of histopathology, biomechanical properties, echo intensity, and ultrasound features in a collagenase-induced tendinopathy model of rat Achilles tendons, and to examine the associations among biomechanical properties, echo intensity, and ultrasound features. Forty-two rats received an ultrasound-guided collagenase injection on their left Achilles tendons, and needle puncture on the right ones as the control. At four, eight, and twelve weeks post-injury, the tendons were examined via measurements of their biomechanical properties, histopathological and ultrasonographic characteristics...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683962/arginine-nitric-oxide-metabolites-and-cardiac-dysfunction-in-patients-with-breast-cancer
#8
Brian S Finkelman, Mary Putt, Teresa Wang, Le Wang, Hari Narayan, Susan Domchek, Angela DeMichele, Kevin Fox, Jennifer Matro, Payal Shah, Amy Clark, Angela Bradbury, Vivek Narayan, Joseph R Carver, W H Wilson Tang, Bonnie Ky
BACKGROUND: Oxidative/nitrosative stress and endothelial dysfunction are hypothesized to be central to cancer therapeutics-related cardiac dysfunction (CTRCD). However, the relationship between circulating arginine-nitric oxide (NO) metabolites and CTRCD remains unstudied. OBJECTIVES: This study sought to examine the relationship between arginine-NO metabolites and CTRCD in a prospective cohort of 170 breast cancer patients treated with doxorubicin with or without trastuzumab...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28660735/impact-of-standardized-clinical-assessment-and-management-plans-on-resource-utilization-and-costs-in-children-after-the-arterial-switch-operation
#9
Rahul H Rathod, Brittney Jurgen, Rose A Hamershock, Kevin G Friedman, Audrey C Marshall, Mihail Samnaliev, Dionne A Graham, Kathy Jenkins, James E Lock, Andrew J Powell
BACKGROUND: Standardized Clinical Assessment and Management Plans (SCAMPs) are a quality improvement initiative designed to reduce unnecessary utilization, decrease practice variation, and improve patient outcomes. We created a novel methodology, the SCAMP managed episode of care (SMEOC), which encompasses multiple encounters to assess the impact of the arterial switch operation (ASO) SCAMP on total costs. METHODS: All ASO SCAMP patients (dates March 2009 to July 2015) were compared to a control group of ASO patients (January 2001 to February 2009)...
June 28, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28645653/catalase-overexpression-modulates-metabolic-parameters-in-a-new-stress-less-leptin-deficient-mouse-model
#10
Deborah L Amos, Tanner Robinson, Melissa B Massie, Carla Cook, Alexis Hoffsted, Courtney Crain, Nalini Santanam
Oxidative stress plays a key role in obesity by modifying the function of important biological molecules, thus altering obesogenic pathways such as glucose and lipid signaling. Catalase, is an important endogenous antioxidant enzyme that catabolizes hydrogen peroxide produced by the dismutation of superoxide. Recent studies have shown knockdown of catalase exacerbates insulin resistance and leads to obesity. We hypothesized that overexpressing catalase in an obese mouse will modulate obesogenic pathways and protect against obesity...
June 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28645448/takotsubo-syndrome-presenting-as-syncope-in-a-patient-with-permanent-pacemaker
#11
Bharatraj Banavalikar, Sivasankaran Sivasubramonian, Narayanan Namboodiri, Krishna Kumar Mohanan Nair, Dibya Ranjan Behera, Ajitkumar Valaparambil
Takotsubo syndrome is an acute reversible heart failure syndrome triggered by physical or emotional stress, especially in postmenopausal women. Herein, we describe a case of a 31-year-old pacemaker dependent lady who presented with syncope after she was bereaved of her father. Electrocardiogram at admission revealed ventricular paced rhythm at 60/min, prolonged QT interval and frequent runs of torsades de pointes. Transthoracic echocardiogram and left ventriculogram revealed findings typical of Takotsubo syndrome...
May 18, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28639988/stress-echo-in-italy-state-of-the-art-2015
#12
Quirino Ciampi, Rodolfo Citro, Sergio Severino, Graziana Labanti, Lauro Cortigiani, Rosa Sicari, Nicola Gaibazzi, Maurizio Galderisi, Eduardo Bossone, Paolo Colonna, Eugenio Picano
No abstract text is available yet for this article.
August 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28637508/hyperpolarized-13-c-urea-myocardial-first-pass-perfusion-imaging-using-velocity-selective-excitation
#13
Maximilian Fuetterer, Julia Busch, Sophie M Peereboom, Constantin von Deuster, Lukas Wissmann, Miriam Lipiski, Thea Fleischmann, Nikola Cesarovic, Christian T Stoeck, Sebastian Kozerke
BACKGROUND: A velocity-selective binomial excitation scheme for myocardial first-pass perfusion measurements with hyperpolarized (13)C substrates, which preserves bolus magnetization inside the blood pool, is presented. The proposed method is evaluated against gadolinium-enhanced (1)H measurements in-vivo. METHODS: The proposed excitation with an echo-planar imaging readout was implemented on a clinical CMR system. Dynamic myocardial stress perfusion images were acquired in six healthy pigs after bolus injection of hyperpolarized (13)C urea with the velocity-selective vs...
June 21, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28631761/-management-of-outpatients-with-cardiac-disease-follow-up-timing-and-modalities
#14
Roberta Rossini, Daniela Lina, Marco Ferlini, Giuseppina Belotti, Salvatore Ivan Caico, Fabrizio Caravati, Pompilio Faggiano, Annamaria Iorio, Davide Lauri, Corrado Lettieri, Emanuela Teresa Locati, Antonio Maggi, Ferdinando Massari, Andrea Mortara, Luigi Moschini, Giuseppe Musumeci, Daniele Nassiacos, Fabrizio Negri, Domenico Pecora, Simona Pierini, Roberto Pedretti, Pierfranco Ravizza, Michele Romano, Fabrizio Oliva
The increasing rate of cardiovascular diseases, the improved survival after the acute phase, the aging of the population and the implementation of primary prevention caused an exponential increase in outpatient cardiac performance, thereby making it difficult to maintain a balance between the citizen-patient request and the economic sustainability of the healthcare system. On the other side, the prescription of many diagnostic tests with a view to defensive medicine and the related growth of patients' expectations, has led several scientific societies to educational campaigns highlighting the concept that "less is more"...
June 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28616350/anomalous-right-coronary-artery-origin-with-interarterial-pathway-importance-of-morphological-origin-assessment-and-the-role-of-percutaneous-interventionism
#15
Daniel García Iglesias, Lidia Martínez Fernández, María Martín Fernández, Laura García Suárez, Laura García Pérez, Juan Calvo Blanco, Helena Cigarrán Sexto, Raquel Del Valle Fernández, César Morís de la Tassa
Anomalies in coronary arteries (CA) are an important issue in cardiology and cardiovascular surgery. Specifically the anomalous origin of the right coronary artery (RCA) is of special importance because it is the most frequent anomaly. Clinical practice guidelines recommend the revascularization treatment in cases of interarterial pathway and documented myocardial ischemia and when hypoplasia, compression or obstruction is evident. We report two different cases of patients with anomalous origin of RCA and associated interarterial pathway...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28611231/validation-of-the-left-ventricular-ejection-fraction-with-iq-spect-system-in-small-heart-patients
#16
Hiroto Yoneyama, Takayuki Shibutani, Takahiro Konishi, Asuka Mizutani, Hashimoto Ryosuke, Masahisa Onoguchi, Koichi Okuda, Shinro Matsuo, Kenichi Nakajima, Kinuya Seigo
The IQ-SPECT system equipped with a multifocal (SMARTZOOM) collimator using an ordered subset conjugate gradient minimization (OSCGM) algorithm reduces the acquisition time of myocardial perfusion imaging (MPI) compared to conventional gamma cameras equipped with low-energy high-resolution (LEHR) collimators. We compared IQ-SPECT with a conventional single-photon emission computed tomography (SPECT) system for estimating the left ventricular ejection fraction (LVEF) in small-heart patients. Methods: The study group consisted of 98 consecutive patients who underwent a 1-day stress-rest MPI study with a (99m)Tc-labeled agent for preoperative risk assessment...
June 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28600985/nox2-contributes-to-hyperinsulinemia-induced-redox-imbalance-and-impaired-vascular-function
#17
Abeer M Mahmoud, Mohamed M Ali, Edwin R Miranda, Jacob T Mey, Brian K Blackburn, Jacob M Haus, Shane A Phillips
Insulin resistance promotes vascular endothelial dysfunction and subsequent development of cardiovascular disease. Previously we found that skeletal muscle arteriolar flow-induced dilation (FID) was reduced following a hyperinsulinemic clamp in healthy adults. Therefore, we hypothesized that hyperinsulinemia, a hallmark of insulin resistance, contributes to microvascular endothelial cell dysfunction via inducing oxidative stress that is mediated by NADPH oxidase (Nox) system. We examined the effect of insulin, at levels that are comparable with human hyperinsulinemia on 1) FID of isolated arterioles from human skeletal muscle tissue in the presence and absence of Nox inhibitors and 2) human adipose microvascular endothelial cell (HAMECs) expression of nitric oxide (NO), endothelial NO synthase (eNOS), and Nox-mediated oxidative stress...
June 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28596817/cardiovascular-assessment-in-liver-transplant-for-non-alcoholic-steatohepatitis-patients-what-we-do-what-we-should-do
#18
REVIEW
Yolanda Sanchez-Torrijos, Javier Ampuero, Manuel Romero-Gómez
Non-alcoholic fatty liver disease (NAFLD) is increasing considerably due to the current lifestyle, which means that it is becoming one of the main indications for liver transplantation. On the other hand, there is a strong association between NAFLD and cardiovascular disease. This has been evidenced in many studies revealing a higher presence of carotid plaques or carotid intima-media thickness, leading to cardiovascular events and, ultimately, mortality. According to the liver transplant guidelines, screening for heart disease in transplant candidates should be performed by electrocardiogram and transthoracic echocardiography while a stress echocardiogram should be reserved for those with more than two cardiovascular risk factors or greater than 50 years old...
May 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28588804/peripartum-cardiomyopathy-what-if-your-patient-plans-to-reconceive
#19
Rashed Al Bannay, Aysha Husain, Zainab AlJufairi
Patients with peripartum cardiomyopathy (PPCM) often express a desire to conceive again, and the risk of relapse in future pregnancies should be disclosed. No consensus is available that can determine that risk. Adequate contractile reserve, evidenced by a stress echocardiogram (exercise or dobutamine), can identify those with lower relapse risk.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28577159/biventricular-thrombosis-in-biventricular-stress-takotsubo-cardiomyopathy
#20
Luisa De Gennaro, Massimo Ruggiero, Sergio Musci, Francesco Tota, Domenica De Laura, Manuela Resta, Nicola Locuratolo, Francesco Santoro, Natale Daniele Brunetti, Pasquale Caldarola
Endo-ventricular thrombosis represents a possible clinical complication of stress(takotsubo)-cardiomyopathy (SC). Depressed ventricular systolic ventricular function, localized left ventricular (LV) dyskinesis, but also an increased pro-thrombotic state induced by catecholamine surge may facilitate the occurrence of endovascular thrombosis in SC. SC, however, may also present as right ventricular (RV) dysfunction or even as biventricular ballooning. Ventricular thrombosis may therefore theoretically occur in either ventricles or both...
August 2017: Journal of Thrombosis and Thrombolysis
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