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poisoning overdose

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https://www.readbyqxmd.com/read/29785585/poisoning-associated-with-inappropriate-use-of-a-eutectic-mixture-of-lidocaine-and-prilocaine-before-laser-assisted-hair-removal-about-3-cases
#1
Weniko Caré, Islam-Amine Larabi, Jérôme Langrand, Chantal Medernach, Jean-Claude Alvarez, Antoine Villa
BACKGROUND: Eutectic mixtures of lidocaine and prilocaine are used during painful dermatological procedures. Poisoning is rarely reported in adults. MATERIAL AND METHOD: We report three cases of women who experienced lidocaine and prilocaine poisoning after laser-assisted hair removal. Plasma levels of local anesthetics were assayed by a fully validated liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method. CASE REPORTS: The rules of application of the anesthetic cream were observed apart from the maximum dose and/or maximum surface area...
May 21, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29782961/baclofen-induced-encephalopathy-in-overdose-modeling-of-the-electroencephalographic-effect-concentration-relationships-and-contribution-of-tolerance-in-the-rat
#2
Magali Chartier, Isabelle Malissin, Salma Tannous, Laurence Labat, Patricia Risède, Bruno Mégarbane, Lucie Chevillard
Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics, is responsible for increasing poisonings. Baclofen overdose may induce severe encephalopathy and electroencephalographic (EEG) abnormalities. Whether prior prolonged baclofen treatment may influence the severity of baclofen-induced encephalopathy in overdose has not been established. We designed a rat study to characterize baclofen-induced encephalopathy, correlate its severity with plasma concentrations and investigate the contribution of tolerance...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29693268/poisoning-severity-associated-with-a-range-of-medications-in-suicide-attempts-by-ingestion
#3
Kenneth R Conner, Timothy J Wiegand, Rachel Gorodetsky, Rachel F Schult, Kimberly Kaukeinen
There are limited data on the medical severity of suicide attempts by intentional self-poisoning (ISP) associated with ingestion of differing classes of medications and meager data on specific agents. The purpose of the study was to address these gaps. This was an analysis of a consecutive series of ISP cases ages 13 to 65 treated at a U.S. university medical center (N = 671). The outcome, poisoning severity, was dichotomized as "moderate-severe" and "low" (reference) based on a standard measure...
April 25, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29681419/physostigmine-reversal-of-dysarthria-and-delirium-after-iatrogenic-atropine-overdose-from-a-dental-procedure
#4
Jon B Cole, Benjamin S Orozco, Ann M Arens
BACKGROUND: Sublingual atropine, dosed at 0.4-0.8 mg, is used by dentists as an antisialogogue to facilitate and increase the speed of procedures. Concentrated ophthalmic atropine drops (10 mg/mL) are commonly used off-label for this purpose. These highly concentrated drops may result in medication errors, atropine toxicity, and the antimuscarinic toxidrome. We report a case of a man who suffered acute delirium and dysarthria (from dry mouth) after an iatrogenic overdose from a dental procedure...
April 19, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29628190/prognostic-utility-of-initial-lactate-in-patients-with-acute-drug-overdose-a-validation-cohort
#5
Randy Cheung, Robert S Hoffman, David Vlahov, Alex F Manini
STUDY OBJECTIVE: Previous studies have suggested that the initial emergency department (ED) lactate concentration may be an important prognostic indicator for inhospital mortality from acute drug poisoning. We conduct this cohort study to formally validate the prognostic utility of the initial lactate concentration in a larger, distinct patient population with acute drug overdose. METHODS: This observational, prospective, cohort study was conducted during 5 years at 2 urban teaching hospitals...
April 6, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29622340/frequency-of-poison-center-exposures-for-pediatric-accidental-unsupervised-ingestions-of-acetaminophen-after-the-introduction-of-flow-restrictors
#6
Eric P Brass, Kate M Reynolds, Randy I Burnham, Jody L Green
OBJECTIVE: To assess the temporal association of flow restrictor introduction and the rate of accidental unsupervised ingestions (AUIs) of liquid acetaminophen products. STUDY DESIGN: The National Poison Data System was used to identify AUIs of single ingredient acetaminophen in patients aged <12 years reported between 2007 and 2015. Six regional poison centers obtained additional information using a structured telephone survey. RESULTS: Pediatric AUIs involving acetaminophen averaged 30 000 exposures per year between 2007 and 2012...
April 2, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29616901/issues-in-developing-a-surveillance-case-definition-for-nonfatal-suicide-attempt-and-intentional-self-harm-using-international-classification-of-diseases-tenth-revision-clinical-modification-icd-10-cm-coded-data
#7
Holly Hedegaard, Michael Schoenbaum, Cynthia Claassen, Alex Crosby, Kristin Holland, Scott Proescholdbell
Suicide and intentional self-harm are among the leading causes of death in the United States. To study this public health issue, epidemiologists and researchers often analyze data coded using the International Classification of Diseases (ICD). Prior to October 1, 2015, health care organizations and providers used the clinical modification of the Ninth Revision of ICD (ICD-9-CM) to report medical information in electronic claims data. The transition in October 2015 to use of the clinical modification of the Tenth Revision of ICD (ICD-10-CM) resulted in the need to update methods and selection criteria previously developed for ICD-9-CM coded data...
February 2018: National Health Statistics Reports
https://www.readbyqxmd.com/read/29611486/why-methylene-blue-have-to-be-always-present-in-the-stocking-of-emergency-antidotes
#8
Caroline Floreoto Baldo, Luiza Mateus Silva, Livia Arcencio, Agnes Afrodite Sumarelli Albuquerque, Andrea Carla Celotto, Anibal Basile-Filho, Paulo Roberto B Evora
Evidence-based review of the existing literature ultimately recommends stocking of methylene blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning...
April 2, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29609498/trends-in-intentional-abuse-or-misuse-of-benzodiazepines-and-opioid-analgesics-and-the-associated-mortality-reported-to-poison-centers-across-the-united-states-from-2000-to-2014
#9
S L Calcaterra, S G Severtson, G E Bau, Z R Margolin, B Bucher-Bartelson, J L Green, R C Dart
CONTEXT: Prior works demonstrates an increased risk of death when opioid analgesics and benzodiazepines are used concomitantly to gain a high. Using poison center data, we described trends in abuse or misuse of benzodiazepines and opioid analgesics. We quantified mortality risk associated with abuse or misuse of benzodiazepines, opioid analgesics and the combination of opioid analgesics and benzodiazepines. METHODS: This was a retrospective chart review of data from the National Poison Data System which collects information from 55 poison centers located across the United States...
April 3, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29587543/iron-overdose-epidemiology-clinical-features-and-iron-concentration-effect-relationships-the-uk-experience-2008-2017
#10
D Nicholas Bateman, Victoria Eagling, Euan A Sandilands, Gill Jackson, Catherine Crawford, Leonard Hawkins, Ted Cheung, Gillian Cooper, Sally M Bradberry, John P Thompson, Simon H L Thomas, Michael Eddleston
BACKGROUND: Iron poisoning is potentially serious, but mortality has fallen worldwide since implementation of pack size and packaging restrictions, and changes in iron use during pregnancy. The management of individual cases of overdose remains problematic due to uncertainty about indications for antidote. We examine the epidemiology of iron overdose in hospital cases referred to the UK National Poisons Information Service (NPIS) and evaluate the toxicokinetics of iron in patients ingesting only iron preparations...
March 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29582394/comparative-rates-of-mortality-and-serious-adverse-effects-among-commonly-prescribed-opioid-analgesics
#11
David L Murphy, Jacob A Lebin, Stevan G Severtson, Heather A Olsen, Nabarun Dasgupta, Richard C Dart
INTRODUCTION: The epidemic of prescription opioid overdose and mortality parallels the dispensing rates of prescription opioids, and the availability of increasingly potent opioid analgesics. OBJECTIVE: The common assumption that more potent opioid analgesics are associated with higher rates of adverse outcomes has not been adequately substantiated. We compared the rate of serious adverse events among commonly prescribed opioid analgesics of varying potency. METHODS: Serious adverse events (SAEs; defined as death, major medical effect, or hospitalization) resulting from exposure to tablets containing seven opioid analgesics (oxycodone, hydrocodone, morphine, hydromorphone, oxymorphone, tapentadol, and tramadol) captured by the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS® ) System Poison Center Program were evaluated from 2010 through 2016...
March 26, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29579890/molecular-adsorbent-recirculating-system-treatment-can-reduce-blood-levels-of-n-acetylcysteine-in-patients-with-acetaminophen-overdose-case-reports
#12
V Lopez-Lopez, J Ros, D Ferreras, J Sanmartin, M Martinez, J A Pons Miñano, F Sanchez-Bueno, R Robles-Campos, P Ramirez-Romero, P Parrilla-Paricio
BACKGROUND: Acetaminophen poisoning continues to be a major cause of liver failure that can lead to liver transplantation. N-acetylcysteine (NAC) is the cornerstone of treatment. Some authors use a Molecular Adsorbent Recirculating System (MARS) system in acetaminophen poisoning. It is reported that the MARS system eliminates acetaminophen more efficiently than conventional dialysis. It is theoretically possible that treatment with MARS administered after NAC will increase the effectiveness of treatment...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29553358/trends-in-injector-deaths-in-ireland-as-recorded-by-the-national-drug-related-deaths-index-1998-2014
#13
Therese M Lynn, Ena Lynn, Eamon Keenan, Suzi Lyons
OBJECTIVE: The purpose of this study was to provide trend analysis on all deaths among drug users who injected at or around the time of their death in Ireland between 1998 and 2014. METHOD: A review of the data recorded by the National Drug-Related Deaths Index (NDRDI) was conducted to identify individuals who were known to be injecting at or around the time of their death, from 1998 to 2014. RESULTS: Between 1998 and 2014, 16,500 deaths were recorded by the NDRDI...
March 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29543597/determinants-of-lactic-acidosis-in-acute-cyanide-poisonings
#14
Frédéric J Baud, Mohamad K Haidar, Romain Jouffroy, Jean-Herlé Raphalen, Lionel Lamhaut, Pierre Carli
OBJECTIVES: To investigate the magnitude of lactic acidosis in response to cyanide poisoning compared with the secondary response caused by cardiovascular shock. DESIGN: Retrospective case-control observational study. SETTING: University Hospital of Assistance Publique - Hôpitaux de Paris. SUBJECTS: Patients admitted for suspicion of cyanide poisoning or drug overdose. Medical charts provided by Assistance Publique - Hôpitaux de Paris of patients between January 1988 and December 2015...
June 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29537318/pregnancy-outcomes-after-suicide-attempts-by-self-poisoning-and-drug-overdose-experience-of-a-clinical-pharmacology-consultation-service-in-izmir-turkey
#15
Zeynep Ozturk, Kadriye Ugras
No abstract text is available yet for this article.
March 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29532759/amlodipine-150-mg-poisoning-a-case-study
#16
Prasan Kumar Panda, Annu Raj, Shiv Shankar Singh
Treatments of patient with amlodipine (a calcium channel blocker, CCB) overdose/poisoning remain challenging and death is certain if not intervened timely. Furthermore, for a society, the availability and common use of this drug make more vulnerable, especially by children, towards an accidental/suicidal poisoning. Here we describe an adolescent school girl who took 150 mg of amlodipine and was admitted in our hospital approximately 4 hours after ingestion with suicidal intention. She developed circulatory failure and tachypnea...
March 13, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29512803/attempted-suicide-by-fl%C3%A3-cainide-overdose-a-case-report
#17
Mouna Ben Kilani, Soufia Naccache, Rami Tlili, Dorra Mbarek, Salma Longo, Youssef Ben Ameur, Mohamed Rachid Boujnah
Class Ic antiarrythmic overdose is associated with a relatively high mortality. We presenta case report regarding a suicidal intoxication of an 18-year old female with a medical history of Wolff-Parkinson-White syndrome. The preliminary examination highlighted a profound cardiovascular collapse. The electrocardiogram showed a PR interval extended to 360 ms. The QRS complexes were enlarged to 360 ms with a right bundle brunch block appearance associated with left posterior hemibloc. There were repolarization abnormalities such as elevation of the J-point, convex ST segment and biphasic T wave in the right precordial leads ("Brugada-Like ECG pattern")...
June 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29498021/prescribed-dose-of-opioids-and-overdose-a-systematic-review-and-meta-analysis-of-unintentional-prescription-opioid-overdose
#18
REVIEW
Adeleke D Adewumi, Samantha A Hollingworth, Joemer C Maravilla, Jason P Connor, Rosa Alati
BACKGROUND: The rate of an unintentional drug overdose involving prescription opioids continues to rise. An understanding of the threshold dose and dose(s) associated with unintentional prescription opioid overdose will help to mitigate this epidemic. OBJECTIVE: The objective of this systematic review is to systematically synthesise and meta-analyse studies on doses of prescription opioids and ascertain the doses of opioids that are associated with increased risk of severe opioid poisoning or mortality...
February 2018: CNS Drugs
https://www.readbyqxmd.com/read/29491713/effect-of-mrsa-on-cyp450-dynamic-changes-of-cytokines-oxidative-stress-and-drug-metabolizing-enzymes-in-mice-infected-with-mrsa
#19
Huaqiao Tang, Nana Long, Lin Lin, Yao Liu, Jianlong Li, Fenghui Sun, Lijuan Guo, Fen Zhang, Min Dai
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a very damaging and widespread pathogen, which is associated with many diseases and causes serious infections. MRSA infection can modulate the effects of drugs, which may occur through an influence on cytochrome P450 (CYP450), the drug-metabolizing enzyme in the liver. In this study, we evaluated the underlying mechanism of drug failure or poisoning in MRSA infection. Materials and methods: Mice were infected with three different doses of MRSA and the changes in CYP450 expression, cytokines, and oxidative stress markers were evaluated...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29479972/observational-study-of-dermatological-manifestations-in-patients-admitted-to-a-tertiary-poison-center-in-iran
#20
Hale Talaie, Soheila Nasiri, Mehdi Gheisari, Sahar Dadkhahfar, Soma Ahmadi
Background/aim: Acute unintentional and deliberate poisoning by medications and chemicals is a frequent emergency, especially in Iran. This study aimed to evaluate the frequency and character of skin findings occurring in patients with acute intentional and aunintentional poisoning. Materials and methods: This prospective observational study was performed at the Loghman Hakim Hospital Poison Center over a period of 6 months from April 2016 to September 2016. Data including patient demographics, cause of poisoning, and level of consciousness were collected...
February 23, 2018: Turkish Journal of Medical Sciences
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