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https://www.readbyqxmd.com/read/29643912/association-of-rage-gene-polymorphism-with-type-2-diabetes-mellitus-in-local-population
#1
Saba Zulfiqar, Fatma Hussain, Amer Jamil, Nisar Ahmed
Objectives: Type-2 diabetes mellitus (T2DM) is an endocrine disease having a significant genetic component. Polymorphisms of many genes may affect hereditary vulnerability of the disease that is characterized by insulin resistance and islet disorder. As the genetic basis of T2DM can vary between ethnic groups, it is important to investigate the genetic link of T2DM in Pakistani populace. This study was aimed to assess the association of receptor for advanced glycation end product (RAGE) gene polymorphism (-429T>C) with Type-2 diabetes mellitus within local populace...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643908/lack-of-association-of-statin-use-with-vitamin-d-levels-in-a-hospital-based-population-of-type-2-diabetes-mellitus-patients
#2
Khalida Iqbal, Najmul Islam, Iqbal Azam, Naseema Mehboobali, Mohammad Perwaiz Iqbal
Objective: To investigate the relationship of statins (drug given to reduce serum levels of LDL-cholesterol) on vitamin D levels of Pakistani type 2 diabetes mellitus (DM) patients in a hospital in Karachi. Methods: In a cross-sectional survey, 312 consecutive patients with type 2 DM (219 males and 93 females, age 22-70 years) were recruited with informed consent. A questionnaire was administered to find out whether they were statin users or non-users. Serum was analyzed for concentrations of 25(OH) vitamin D [25(OH)D] and other related biomarkers such as serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, phosphate and calcium using kit methods...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643884/brachdactyly-instigated-as-a-result-of-mutation-in-gdf5-and-nog-genes-in-pakistani-population
#3
Samiullah Khan, Muhammad Mudassir, Naqab Khan, Asmatullah Marwat
Objectives: Brachdactyly a genetic disorder associated with the abnormal development of metacarpals, phalanges or both which results in the shortening of hands and feet. Mutations in the contributing genes has been recognized with the majority of the investigated syndromic form of brachdactyly. The current study was proposed to examine mutation in NOG and GDF5 genes in a Pakistani family. Methods: Poly Acrylamide Gel Electrophoresis and Polymerase Chain Reaction was used for the genomic screening and linkage analysis to observe the mutation in genes...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29611532/a-disease-causing-novel-missense-mutation-in-the-st14-gene-underlies-autosomal-recessive-ichthyosis-with-hypotrichosis-syndrome-in-a-consanguineous-family
#4
Farooq Ahmad, Ishtaiq Ahmed, Abdul Nasir, Muhammad Umair, Shaheen Shahzad, Dost Muhammad, Regie Lyn P Santos-Cortez, Suzanne M Leal, Wasim Ahmad
Autosomal recessive ichthyosis with hypotrichosis (ARIH; MIM 602400) syndrome is characterized by diffused congenital ichthyosis and generalized non-scarring hypotrichosis. The underlying genetic cause of ARIH syndrome has been associated with sequence variants of the gene ST14, encoding type II transmembrane serine protease matriptase, which maps to chromosome 11q24.3. The current report aimed to investigate the clinical features and genetic cause of ARIH syndrome in a large consanguineous family of Pakistani origin...
March 27, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29593946/prevalence-of-type-2-diabetes-mellitus-among-urban-bihari-communities-in-dhaka-bangladesh-a-cross-sectional-study-in-a-minor-ethnic-group
#5
Muhammad Asaduzzaman, Shahanaz Chowdhury, Jahid Hossen Shahed, Mohammad Abdullah Heel Kafi, Md Nazim Uzzaman, Mahfuza Talukder Flowra, Msa Mansur Ahmed
Introduction The prevalence, disease progression, and treatment outcomes for patients with type 2 diabetes vary significantly between ethnic groups. The Bihari community constitutes one of the most vulnerable populations in Bangladesh on the basis of access to health services and other fundamental rights. Our study aimed at finding out the prevalence and risk factors of type 2 diabetes among the Bihari adults in Dhaka city. Methods This cross-sectional community-based study was carried out among stranded Pakistanis (known as Bihari) living in camps in the Mirpur area from July 2014 to June 2015...
January 26, 2018: Curēus
https://www.readbyqxmd.com/read/29592981/burn-aggravated-infected-wart-in-a-patient-with-type-2-diabetes-a-medical-challenge
#6
Tahseen Ahmed Khan, Mahmood Sheikh, Iqbal Azher, Abdul Khaliq Sheikh
An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Patient then travelled to Saudi Arabia for pilgrimage 3 days later with growth of Staphylococcus aureus and Proteus species in culture and sensitivity report; during his travel, he walked barefoot and the infected wart aggravated with severe burn...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29557278/the-effect-of-perceiving-a-calling-on-pakistani-nurses-organizational-commitment-organizational-citizenship-behavior-and-job-stress
#7
Bilal Afsar, Asad Shahjehan, Sadia Cheema, Farheen Javed
INTRODUCTION: People differ considerably in the way in which they express and experience their nursing careers. The positive effects associated with having a calling may differ substantially based on individuals' abilities to live out their callings. In a working world where many individuals have little to no choice in their type of employment and thus are unable to live out a calling even if they have one, the current study examined how perceiving a calling and living a calling interacted to predict organizational commitment, organizational citizenship behavior, and job stress with career commitment mediating the effect of the interactions on the three outcome variables...
March 1, 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29552790/haplotype-analysis-of-xrcc1-gene-polymorphisms-and-the-risk-of-thyroid-carcinoma
#8
Kashif Bashir, Romana Sarwar, Shazia Fatima, Soma Saeed, Ishrat Mahjabeen, Mahmood Akhtar Kayani
PURPOSE: Variants in DNA repair genes may alter the repair mechanisms that make the persons vulnerable to DNA damage. These polymorphic variants in the DNA repair pathway genes, such as XRCC1, have been associated with susceptibility of several types of cancer including thyroid cancer. This study was designed to explore the link between XRCC1 polymorphisms and modulation of thyroid cancer risk. METHODS: Our study consisted of 456 thyroid cancer patients and 400 controls...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29552025/new-insights-on-water-buffalo-genomic-diversity-and-post-domestication-migration-routes-from-medium-density-snp-chip-data
#9
Licia Colli, Marco Milanesi, Elia Vajana, Daniela Iamartino, Lorenzo Bomba, Francesco Puglisi, Marcello Del Corvo, Ezequiel L Nicolazzi, Sahar S E Ahmed, Jesus R V Herrera, Libertado Cruz, Shujun Zhang, Aixin Liang, Guohua Hua, Liguo Yang, Xingjie Hao, Fuyuan Zuo, Song-Jia Lai, Shuilian Wang, Ruyu Liu, Yundeng Gong, Mahdi Mokhber, Yongjiang Mao, Feng Guan, Augustin Vlaic, Bogdan Vlaic, Luigi Ramunno, Gianfranco Cosenza, Ali Ahmad, Ihsan Soysal, Emel Ö Ünal, Mariena Ketudat-Cairns, José F Garcia, Yuri T Utsunomiya, Pietro S Baruselli, Maria E J Amaral, Rangsun Parnpai, Marcela G Drummond, Peter Galbusera, James Burton, Eileen Hoal, Yulnawati Yusnizar, Cece Sumantri, Bianca Moioli, Alessio Valentini, Alessandra Stella, John L Williams, Paolo Ajmone-Marsan
The domestic water buffalo is native to the Asian continent but through historical migrations and recent importations, nowadays has a worldwide distribution. The two types of water buffalo, i.e., river and swamp, display distinct morphological and behavioral traits, different karyotypes and also have different purposes and geographical distributions. River buffaloes from Pakistan, Iran, Turkey, Egypt, Romania, Bulgaria, Italy, Mozambique, Brazil and Colombia, and swamp buffaloes from China, Thailand, Philippines, Indonesia and Brazil were genotyped with a species-specific medium-density 90K SNP panel...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29542096/remotely-piloted-life-saving-effort-vehicles-and-emergency-management-an-analysis-on-revolutionizing-humanitarian-assistance-in-pakistan
#10
Ali Bin Nadeem, Ysa Chandna
The majority of the Pakistani public has known little of the unmanned aerial vehicles, also known for their onomatopoeically inspired name "drones," except the fact that it regularly rains Hellfire missiles in Pakistan, claiming the lives of many innocent Pakistanis settled in the western provinces. In actuality, in addition to their destructive capacities, these remotely piloted vehicles have been used since the turn of the century in a variety of live-saving and risk-reducing roles. This research article primarily addresses the third stage of Emergency management-response, with Pakistan being the primary region of research...
January 2018: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29540878/evaluation-of-root-morphology-and-canal-configuration-of-maxillary-premolars-in-a-sample-of-pakistani-population-by-using-cone-beam-computed-tomography
#11
Muhammad Rizwan Nazeer, Farhan Raza Khan, Robia Ghafoor
OBJECTIVE: To evaluate the root canal morphology of maxillary premolars. METHODS: his retrospective study was conducted from November 2016 to January 2017 at Aga Khan University Hospital, Karachi, and reviewed Cone Beam Computed Tomography images of maxillary first and second premolars done from November 2014 to October 2016. Frequency distribution of Vertucci's classification was determined. Chi square test was applied to determine any association between Vertucci's type and gender...
March 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29524198/molecular-characterization-of-pneumococcal-surface-protein-a-pspa-serotype-distribution-and-antibiotic-susceptibility-of-streptococcus-pneumoniae-strains-isolated-from-pakistan
#12
Faidad Khan, Mohsin Ahmad Khan, Nadeem Ahmed, Muhammad Islam Khan, Hamid Bashir, Saad Tahir, Ahmad Usman Zafar
INTRODUCTION: Pakistan has one of the highest burdens of pneumococcal diseases in the world, but unfortunately studies in this demanding research area are limited in the region. Pneumococcal surface protein A (PspA) is the next generation pneumococcal vaccine candidate as the protein locates on the Streptococcus pneumoniae surface. Its gene, pspA, might be encoded by all pneumococci, and the protein has proven immunogenicity. The molecular characterization of PspA, pneumococcal serotype distribution and antibiotic susceptibility are important for regional diversity studies...
March 9, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29492090/a-study-on-catalase-gene-promoter-polymorphism-21-a-t-rs7943316-in-healthy-pakistani-population
#13
Syeda Nuzhat Nawab, Sitwat Zehra, Asher Fawwad, Abid Azhar
Background & Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2 O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species. It has suggested that CAT-21A/T (rs7943316) OMIM: 115500 gene promoter polymorphism is predominantly associated with different human disorders such as hypertension, cancers, diabetes, nephropathy, and other diseases accompanied by oxidative stress. This study was designed to investigate the prevalence of mutant T allele frequency in healthy individuals...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29479090/mra-based-evaluation-of-anatomical-variation-of-circle-of-willis-in-adult-pakistanis
#14
Rehana Shaikh, Saba Sohail
OBJECTIVE: To determine the frequency and patterns of normal anatomical variation of Circle of Willis on magnetic resonance angiogram in adults without cerebrovascular disease. METHODS: This descriptive cross-sectional study was conducted at the Radiology Department of Dow University of Health Sciences / Civil Hospital, Karachi, from January to December 2016, and comprised patients referred for magnetic resonance imaging of the brain and magnetic resonance angiogram without any clinical or radiological manifestation of cerebrovascular disease, primarily including those with suspected demyelination, infection, epilepsy or metastases...
February 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29465656/herpes-simplex-virus-type-2-seroprevalence-among-different-national-populations-of-middle-east-and-north-african-males
#15
Soha R Dargham, Gheyath K Nasrallah, Enas S Al-Absi, Layla I Mohammed, Rana S Al-Disi, Mariam Y Nofal, Laith J Abu-Raddad
BACKGROUND: There are limited data on herpes simplex virus type 2 (HSV-2) seroprevalence in the Middle East and North Africa (MENA). We examined country- and age-specific HSV-2 seroprevalence among select MENA populations residing in Qatar. METHODS: Sera were collected from male blood donors attending Hamad Medical Corporation June 2013-2016. Specimens were screened for anti-HSV-2 IgG antibodies following a two-test algorithm: HerpeSelect® 2 ELISA was used to identify HSV-2 positive specimens, and Euroline-WB was used to confirm positive and equivocal specimens for final HSV-2 status...
January 16, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29425966/genotype-assembly-biological-activity-and-adaptation-of-spatially-separated-isolates-of-spodoptera-litura-nucleopolyhedrovirus
#16
Ghulam Ali, Marleen H C Abma-Henkens, Wopke van der Werf, Lia Hemerik, Just M Vlak
The cotton leafworm Spodoptera litura is a polyphagous insect. It has recently made a comeback as a primary insect pest of cotton in Pakistan due to reductions in pesticide use on the advent of genetically modified cotton, resistant to Helicoverpa armigera. Spodoptera litura nucleopolyhedrovirus (SpltNPV) infects S. litura and is recognized as a potential candidate to control this insect. Twenty-two NPV isolates were collected from S. litura from different agro-ecological zones (with collection sites up to 600 km apart) and cropping systems in Pakistan to see whether there is spatial dispersal and adaptation of the virus and/or adaptation to crops...
February 6, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29351305/gender-stereotypes-and-education-a-comparative-content-analysis-of-malaysian-indonesian-pakistani-and-bangladeshi-school-textbooks
#17
REVIEW
Kazi Md Mukitul Islam, M Niaz Asadullah
Using government secondary school English language textbooks from Malaysia, Indonesia, Pakistan and Bangladesh, we conducted a quantitative content analysis in order to identify gender stereotypes in school education. In total, 21 categories of exclusion and quality of representation were used to study gender stereotypes. Our analysis confirms a pro-male bias in textbooks: the aggregate female share is 40.4% in textual and pictorial indicators combined. Female occupations are mostly traditional and less prestigious while the characters are predominantly introverted and passive in terms of personality traits...
2018: PloS One
https://www.readbyqxmd.com/read/29322508/a-novel-homozygous-variant-in-bmpr1b-underlies-acromesomelic-dysplasia-hunter-thompson-type
#18
Asmat Ullah, Muhammad Umair, Dost Muhammad, Muhammad Bilal, Kwanghyuk Lee, Suzanne M Leal, Wasim Ahmad
Acromesomelic dysplasia is genetically heterogeneous group of skeletal disorders characterized by short stature and acromelia and mesomelia of limbs. Acromesomelic dysplasia segregates in an autosomal recessive pattern and is caused by biallelic sequence variants in three genes (NPR2, GDF5, and BMPR1B). A consanguineous family of Pakistani origin segregating a subtype of acromesomelic dysplasia called Hunter-Thompson was clinically and genetically evaluated. Genotyping of microsatellite markers and linkage analysis revealed a 7...
January 10, 2018: Annals of Human Genetics
https://www.readbyqxmd.com/read/29237407/identification-and-in-silico-characterization-of-a-novel-p-p208pfsx1-mutation-in-v-atpase-a3-subunit-associated-with-autosomal-recessive-osteopetrosis-in-a-pakistani-family
#19
Muhammad Ajmal, Asif Mir, Sughra Wahid, Chiea Chuen Khor, Jia Nee Foo, Saima Siddiqi, Mehran Kauser, Salman Akbar Malik, Muhammad Nasir
BACKGROUND: Osteopetrosis is a rare inherited bone disorder mainly described as an increased bone density caused by defective osteoclastic bone resorption. To date, genetic variants of eleven genes have been reported so far to be associated with different types of osteopetrosis. However, malignant infantile osteopetrosis, a lethal form of the disease, is mostly (50%) caused by mutation(s) in TCIRG1 gene. In this study, we investigated a consanguineous Pakistani family clinically and genetically to elucidate underlying molecular basis of the infantile osteopetrosis...
December 13, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29209666/novel-duplication-mutation-of-the-dysf-gene-in-a-pakistani-family-with-miyoshi-myopathy
#20
Muhammad I Ullah, Arsalan Ahmad, Milena Zarkovic, Syed S Shah, Abdul Nasir, Saqib Mahmood, Wasim Ahmad, Christian A Hubner, Muhammad J Hassan
To identify the underlying gene mutation in a large consanguineous Pakistani family.  Methods: This is an observational descriptive study carried out at the Department of Biochemistry, Shifa International Hospital, Quaid-i-Azam University, and Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan from 2013-2016. Genomic DNA of all recruited family members was extracted and the Trusight one sequencing panel was used to assess genes associated with a neuro-muscular phenotype...
December 2017: Saudi Medical Journal
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