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https://www.readbyqxmd.com/read/27929723/prevalence-and-risk-factors-of-strabismus-in-a-uk-multi-ethnic-birth-cohort
#1
Alison Bruce, Gillian Santorelli
PURPOSE: To determine the prevalence, types and early-life risk factors associated with strabismus in a multi-ethnic birth cohort of children aged 4-5 years in the first year of school. METHODS: Data were collected prospectively over a 3-year period (2012-2015) from children participating in the vision screening program provided by orthoptists and carried out in schools located in the city of Bradford, UK. Prevalence of strabismus was determined for 17,018 children aged 4 to 5 years...
December 2016: Strabismus
https://www.readbyqxmd.com/read/27908797/molecular-detection-and-characterization-of-respiratory-syncytial-virus-b-genotypes-circulating-in-pakistani-children
#2
Uzma Bashir, Nadia Nisar, Nayab Mahmood, Muhammad Masroor Alam, Hajra Sadia, Syed Sohail Zahoor Zaidi
Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in young children, but very little is known about its epidemiology and circulating genotypes in Pakistan. This study analyzed the epidemiological and molecular characteristics of RSV B genotypes in Pakistani children below 5years with acute respiratory tract infections (ARIs) during three consecutive winter seasons from 2010 to 2013. A total of 1941 samples were analyzed for RSV infection by real time PCR and 24% (472/1941) samples were found positive out of which 22...
November 28, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27872574/prevalence-and-pattern-of-dyslipidemia-in-hyperglycemic-patients-and-its-associated-factors-among-pakistani-population
#3
Maliha Sarfraz, Sanaullah Sajid, Muhammad Aqeel Ashraf
In diabetes mellitus dyslipidemia is one of the major risk factors for cardiovascular disease. In type 2 diabetes mellitus early detection and treatment of dyslipidemia can avoid risk for cardiovascular disorder. The present study was carried to determine the prevalence and pattern of hyperlipidemia in patients with hyperglycemia. The cross sectional study was done in different laboratories of Pakistan, the laboratories served patients referred from different government and private hospitals between July 2014 and June 2015...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27821098/frequency-of-her2-neu-expression-in-colorectal-adenocarcinoma-a-study-from-developing-south-asian-country
#4
Asma Shabbir, Talat Mirza, Abdullah Bin Khalid, Muhammad Asif Qureshi, Sadaf Ahmed Asim
BACKGROUND: Human Epidermal Growth Factor (Her-2/neu) has strong therapeutic implications in certain cancers like breast and gastric cancer. Literature on its frequency in colorectal cancer is scarce. In this study, we have investigated the frequency of Her-2/neu expression in colorectal adenocarcinomas and its association with various clinicopathological variables. METHODS: A total of 95 patients who underwent colonoscopic biopsy or colectomy were studied after Institutional Ethical Approval...
November 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27818685/primary-sjogren-s-syndrome-presenting-as-acute-interstitial-pneumonitis-hamman-rich-syndrome
#5
Abidullah Khan, Mohammad Humayun, Iqbal Haider, Maimoona Ayub, Zakir Shah, Fahad Ajmal
A previously well, 45-year-old Pakistani lady was admitted to the medical unit on-call of Khyber Teaching Hospital (KTH) Peshawar with a 5-day history of fever, productive cough with copious mucoid sputum, dyspnea, and pleuritic chest pain. She also complained of dry eyes, mouth, and vagina. Her chest X-ray showed diffuse alveolar shadowing and arterial gas analysis confirmed type 1 respiratory failure. Over the next few days, she deteriorated rapidly making an urgent transfer to the medical intensive care unit (MICU) necessary, where she was mechanically ventilated...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27812055/carotid-intima-media-thickness-evaluation-by-ultrasound-comparison-amongst-healthy-diabetic-and-hypertensive-pakistani-patients
#6
Waseem Mirza, Mubashir Arain, Arif Ali, Vaqar Bari, Mirza Kazim, Kainat Fatima, Zafar Sajjad, Aziz Jiwani, Nadeem Ahmad
OBJECTIVE: To compare carotid Intima media thickness and atherosclerosis burden amongst healthy, diabetic and hypertensive Pakistani patients. METHODS: A cross-sectional study was carried out at the Department of radiology and family medicine, Aga Khan University Hospital Karachi from April 2014 to July 2015. Bilateral carotid ultrasound was done in 133 healthy adults, 65 hypertensive, 31 type-2 diabetic and 37 hypertensive with type-2 diabetes patients. Normal adults were matched for age and gender...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27764129/the-phylogeographic-and-spatiotemporal-spread-of-hcv-in-pakistani-population
#7
Noor-Ul-Huda Ghori, Atif Shafique, Muhammad Qasim Hayat, Sadia Anjum
Hepatitis C Virus (HCV) is the most prevalent human pathogen in Pakistan and is the major cause of liver cirrhosis and hepatocellular carcinoma in infected patients. It has shifted from being hypo-endemic to being hyper-endemic. There was no information about the origin and evolution of the local variants. Here we use newly developed phyloinformatic methods of sequence analysis to conduct the first comprehensive investigation of the evolutionary and biogeographic history in unprecedented detail and breadth...
2016: PloS One
https://www.readbyqxmd.com/read/27735988/detection-of-flt3-tkd-and-idh1-mutations-in-pakistani-acute-myeloid-leukemia-patients-by-denaturing-hplc
#8
Akbar Ali, Rosemary E Gale, Abdul Rauf Shakoori
Acute myeloid leukemia (AML) is characterized by an increase in the number of myeloid cells in the marrow and an arrest in their maturation. Various genetic mutations are associated with AML. FMS-like tyrosine kinase 3 (FLT3), a member of the class III receptor tyrosine kinase family, plays an important role in stem cell survival, and the development of dendritic and natural killer cells. FLT3/TKD mutations are generally missense mutations or in-frame alterations of residues D835 and I836 within the activation loop of the FLT3 protein...
October 13, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27678447/frameshift-mutation-in-the-apoa5-gene-causing-hypertriglyceridemia-in-a-pakistani-family-management-and-considerations-for-cardiovascular-risk
#9
Sébastien Thériault, Andrew Don-Wauchope, Michael Chong, Ricky Lali, Katherine M Morrison, Guillaume Paré
We report a novel homozygous apolipoprotein A5 (APOA5) frameshift mutation (c.G425del-C, p.Arg143AlafsTer57) identified in a 12-year-old boy of Pakistani origin with severe hypertriglyceridemia (up to 35 mmol/L) and type V hyperlipoproteinemia. The patient did not respond to fibrate therapy, but his condition improved under a very low fat diet, although compliance was suboptimal. Heterozygous status was detected in both parents (consanguineous union) and one sibling, all showing moderate hypertriglyceridemia (between 5 and 10 mmol/L)...
September 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27644653/clinico-hematological-findings-for-classical-hodgkin-s-lymphoma-an-institutional-experience
#10
Sadia Sultan, Syed Mohammed Irfan, Saira Parveen, Saif Ali
BACKGROUND: Classical Hodgkin's lymphoma (cHL) is a B-cell lymphoid neoplasm characterized by a distinctive biological behavior with potentially curable disease characteristics. It is an uncommon hematological malignancy which primarily affects younger individuals. The rationale of this study was to determine its clinico-hematological profile along with stage strati cation in Pakistani patients. MATERIALS AND METHODS: In this descriptive study, adult patients with Hodgkin's lymphoma were enrolled from January 2010 to December 2014...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27636408/increased-prevalence-of-metabolic-risk-factors-in-asian-americans-with-hepatocellular-carcinoma
#11
Alina Kutsenko, Maya R Ladenheim, Nathan Kim, Pauline Nguyen, Vincent Chen, Channa Jayasekera, Ju Dong Yang, Radhika Kumari, Lewis Roberts, Mindie H Nguyen
BACKGROUND: We used metabolic risk factors to estimate the prevalence and clinical significance of nonalcoholic fatty liver disease in Asian Americans with hepatocellular carcinoma (HCC). METHODS: This is a retrospective cohort study of 824 consecutive Asian HCC patients at Stanford University Medical Center from 1998 to 2015. Patients were subdivided as: Chinese, other East Asian (Japanese and Korean), South East Asian (Vietnamese, Thai, and Laotian), Maritime South East Asian (MSEA: Malaysian, Indonesian, Filipino, and Singaporean), and South West Asian (Indian, Pakistani, and Middle Eastern)...
September 15, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27617303/an-exercise-intervention-for-south-asian-mothers-with-risk-factors-for-diabetes
#12
Namratha R Kandula, Swapna Dave, Peter John De Chavez, David X Marquez, Himali Bharucha, Shinu Mammen, Andrea Dunaif, Ronald T Ackermann, Santosh Kumar, Juned Siddique
PURPOSE: South Asians (Indians, Pakistanis, Bangladeshis, Sri Lankans, Nepalis, and Bhutanese) in the United States have a very high prevalence of type 2 diabetes mellitus (DM). This pilot study evaluated a culturally-tailored exercise intervention among South Asian immigrant mothers with DM risk factors. METHODS: Through an academic-community partnership, South Asian women with risk factors for DM and who had at least one child between 6-14 years were enrolled into this single-arm study...
June 15, 2016: Translational Journal of the American College of Sports Medicine
https://www.readbyqxmd.com/read/27571130/fluorine-18-fluorodeoxyglucose-avid-thyroid-incidentalomas-on-pet-ct-scan-in-cancer-patients-how-sinister-are-they
#13
Aamna Hassan, Saima Riaz, Waleed Zafar
OBJECTIVE: To evaluate the prevalence of malignancy in incidental thyroidal uptake on PET with fluorine-18 deoxyglucose integrated with computed tomography (F-FDG PET/CT) in Pakistani cancer patients and to assess the role of standardized uptake value (SUV) in deciding which lesions to investigate further. METHOD: We retrospectively reviewed all patients who underwent F-FDG PET/CT scans over a period of 59 months and further analysed those with visually increased thyroidal uptake...
October 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27539893/effect-of-ethnicity-on-live-birth-rates-after-in-vitro-fertilisation-intracytoplasmic-sperm-injection-treatment-analysis-of-uk-national-database
#14
W Maalouf, W Maalouf, B Campbell, K Jayaprakasan
OBJECTIVE: To evaluate the effect of ethnicity of women on the outcome of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment. DESIGN: Observational cohort study. SETTING: UK National Database. POPULATION: Data from 2000 to 2010 involving 38 709 women undergoing their first IVF/ICSI cycle were analysed. METHODS: Anonymous data were obtained from the Human Fertilization and Embryology Authority (HFEA), the statutory regulator of IVF and ICSI treatment in the UK...
August 19, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27535686/detection-of-anti-hbv-drug-resistance-mutations-based-on-multi-color-melting-curve-analysis
#15
Yi Mou, Muhammad Ammar Athar, Yuzhen Wu, Ye Xu, Jianhua Wu, Zhenxing Xu, Zulfiqar Hayder, Saeed Khan, Muhammad Idrees, Muhammad Israr Nasir, Yiqun Liao, Qingge Li
Detection of anti-HBV drug resistance mutations is critical for therapeutic decision of chronic hepatitis B infection. We described a real-time PCR-based assay using multi-color melting curve analysis (MMCA) that could accurately detect 24 HBV nucleotide mutations at 10 amino acid positions in the reverse transcriptase region of the HBV polymerase gene. The two-reaction assay had a limit of detection of 5 copies per reaction and could detect 5% rtM204V minor mutant population in the presence of the major wild-type population when the overall concentration was 10(4) copies/μL...
August 17, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27512341/concomitant-classic-hodgkin-lymphoma-of-lymph-node-and-cmyc-positive-burkitt-leukemia-lymphoma-of-the-bone-marrow-presented-concurrently-at-the-time-of-presentation-a-rare-combination-of-discordant-lymphomas
#16
Dina S Soliman, Shehab Fareed, Einas Alkuwari, Halima El-Omri, Ahmad Al-Sabbagh, Amna Gameel, Mohamed Yassin
Discordant lymphoma is rare condition in which different types of malignant lymphomas occurring in different anatomic sites. The two diseases may present clinically as concurrent or sequential disease (10). Herein we are reporting a Pakistani female in her 60s, a carrier of hepatitis B virus with multiple comorbidities presented with cervical lymphadenopathy, diagnosed as Hodgkin's lymphoma, mixed cellularity. During the staging workup, the patient was discovered to have extensive bone marrow (BM) involvement by Burkitt leukaemia/lymphoma (BL)...
2016: Clinical Medicine Insights. Blood Disorders
https://www.readbyqxmd.com/read/27510022/breast-lymphoma-treatment-outcomes-in-a-pakistani-population-20-years-of-experience-at-a-single-center
#17
Razia Bano, Waleed Zafar, Amina Iqbal Khan, Sohaib Adil Fiaz, Mahwish Abid, Mohammad Zulqarnain Chaudhary, Neelam Siddique, Huma Majeed Khan
BACKGROUND: Breast lymphomas constitute a rare disease entity. To date, limited relevant data have been reported. We therefore here present a review of breast lymphoma patients treated at a single center over a 20 year period, focusing on histological types, treatment modalities and outcomes. MATERIALS AND METHODS: We identified patients who were diagnosed and treated for breast lymphoma at a single center from January 1995 to January 2014 and extracted data regarding patient demographics and clinical data...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27484350/three-siblings-with-familial-non-medullary-thyroid-carcinoma-a-case-series
#18
Muhammad Owais Rashid, Naeemul Haq, Saad Farooq, Zareen Kiran, Sabeeh Siddique, Shahid Pervez, Najmul Islam
BACKGROUND: In 2015, thyroid carcinoma affected approximately 63,000 people in the USA, yet it remains one of the most treatable cancers. It is mainly classified into medullary and non-medullary types. Conventionally, medullary carcinoma was associated with heritability but increasing reports have now begun to associate non-medullary thyroid carcinoma with a genetic predisposition as well. It is important to identify a possible familial association in patients diagnosed with non-medullary thyroid carcinoma because these cancers behave more destructively than would otherwise be expected...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27472364/segregation-of-incomplete-achromatopsia-and-alopecia-due-to-pde6h-and-lpar6-variants-in-a-consanguineous-family-from-pakistan
#19
Christeen Ramane J Pedurupillay, Erlend Christoffer Sommer Landsend, Magnus Dehli Vigeland, Muhammad Ansar, Eirik Frengen, Doriana Misceo, Petter Strømme
We report on two brothers with visual impairment, and non-syndromic alopecia in the elder proband. The parents were first-degree Pakistani cousins. Whole exome sequencing of the elder brother and parents, followed by Sanger sequencing of all four family members, led to the identification of the variants responsible for the two phenotypes. One variant was a homozygous nonsense variant in the inhibitory subunit of the cone-specific cGMP phosphodiesterase gene, PDE6H:c.35C>G (p.Ser12*). PDE6H is expressed in the cones of the retina, which are involved in perception of color vision...
July 27, 2016: Genes
https://www.readbyqxmd.com/read/27461694/expression-analysis-of-human-epidermal-growth-factor-receptor-type-2-transcripts-in-breast-cancer-cohort-and-its-association-with-clinical-features
#20
Alia Pervez, Syeda Kiran Riaz, Azhar Mehmood, Rakhshanda Rashid, Muhammad Faraz Arshad Malik
AIM OF STUDY: Increased expression of human epidermal growth factor receptor type 2 (HER2) is significantly associated with poor prognosis in breast cancer patients. However, data on HER2 at transcript levels in Pakistani mammary tumor affected females is still limited. In the current study, HER2 transcripts were explored in breast cancer cohort and correlated with various clinical parameters. MATERIALS AND METHODS: Freshly excised tumors along with adjacent normal background tissues of 94 patients were collected at the time of surgery and immediately stored in RNAlater ® solution...
April 2016: Journal of Cancer Research and Therapeutics
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