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Malignant hypertermia

Mariz Vainzof, Danielle Ayub-Guerrieri, Paula C G Onofre, Poliana C M Martins, Vanessa F Lopes, Dinorah Zilberztajn, Lucas S Maia, Karen Sell, Lydia U Yamamoto
The neuromuscular disorders are a heterogeneous group of genetic diseases, caused by mutations in genes coding sarcolemmal, sarcomeric, and citosolic muscle proteins. Deficiencies or loss of function of these proteins leads to variable degree of progressive loss of motor ability. Several animal models, manifesting phenotypes observed in neuromuscular diseases, have been identified in nature or generated in laboratory. These models generally present physiological alterations observed in human patients and can be used as important tools for genetic, clinic, and histopathological studies...
March 2008: Journal of Molecular Neuroscience: MN
D Bernhardt, M H Hörder
Tests are being carried out on 37 patients and healthy volunteers, to differentiate the various, from heart independent, creatin-phosphokinase (CPK) increases, in order to recognize anaesthesia-endangered patients. A rise of the serum-CPK-level, dependent on trauma is insignificant for the anaesthesia. A significant rise of the CPK during a gener al anaesthesia and particularly extreme high values after 24 hours, (example, more than 10 000 U/l) is reason to think of a course of a malignant hyperthermia or myoglobinuria in a subclinical form...
November 18, 1977: Medizinische Klinik
J de la Fuente, J Urzúa, M Allende
No abstract text is available yet for this article.
June 1977: Revista Médica de Chile
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