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T Pilissy, A Toth, G Fazekas, A Sobjak, R Rosenthal, T Luftenegger, P Panek, P Mayer
In the recent decades state of the art technologies appeared in many areas to assist older adults with disabilities. However, one very essential activity of daily life, the toileting remained without any relevant development. The iToilet project of the European Union focuses on the development of an intelligent and motorized toilet system to enable independent toilet use for older adults with disabilities. To begin the development, the user requirements of end-users were assessed by means of focus group interviews and questionnaires...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
Kongzhao Su, Mingyan Wu, Yanxi Tan, Wenjing Wang, Daqiang Yuan, Maochun Hong
Herein, an unprecedented monomeric bowl-like coordination complex, Ti12PgC3 (PgC3 = C-propylpyrogallol[4]arene), has been successfully synthesized. To the best of our knowledge, Ti12PgC3 not only presents the first pyrogallol[4]arene-based titanium coordination complex, but also the highest nuclearity titanium coordination complex in the metal-calixarene system. In addition, this titanium coordination complex can effectively degrade the methylene blue (MB) dye under sunlight.
August 15, 2017: Chemical Communications: Chem Comm
George M Hayward, Anna Rybińska
Following the claim of a highly publicized National Football League (NFL) commercial, we test whether the Super Bowl provides a positive exogenous shock to fertility in counties of winning teams. Using stadium locations to identify teams' counties, we analyze the number of births in counties of both winning and losing teams for ten recent Super Bowls. We also test for state effects and general effects of the NFL playoffs. Overall, our results show no clear pattern of increases in the number of births in winning counties nine months after the Super Bowl...
January 2017: Socius
Chuanchau J Jou, Cammon B Arrington, Spencer Barnett, Jiaxiang Shen, Scott Cho, Xiaoming Sheng, Patrick C McCullagh, Neil E Bowles, Chase M Pribble, Elizabeth V Saarel, Thomas A Pilcher, Susan P Etheridge, Martin Tristani-Firouzi
BACKGROUND/AIMS: Congenital Sick Sinus Syndrome (SSS) is a disorder associated with sudden cardiac death due to severe bradycardia and prolonged pauses. Mutations in HCN4, the gene encoding inward Na+/K+ current (If), have been described as a cause of congenital SSS. The objective of this study is to develop an SSS model in embryonic zebrafish, and use zebrafish as a moderate-throughput assay to functionally characterize HCN4 variants. METHODS: To determine the function of hcn4 in zebrafish, embryos were either bathed in the If -specific blocker (ZD-7288), or endogenous hcn4 expression was knocked down using splice-blocking morpholinos...
August 11, 2017: Cellular Physiology and Biochemistry
Adel Reisi-Vanani, Fatemeh Shamsali
Two conditions are important to obtain appropriate substances for hydrogen storage; high surface area and fitting binding energy (BE). Doping is a key strategy that improves BE. We investigated hydrogen adsorption onto twenty six nitrogen disubstituted isomers of sumanene (C19N2H12) by MP2/6-311++G(d,p)//B3LYP/6-31+G(d) and M06-2X/6-31+G(d) levels of theory. Effect of nitrogen doping in different positions of sumanene was checked. To obtain better BE, basis set superposition error (BSSE) and zero point energy (ZPE) corrections were used...
July 21, 2017: Journal of Molecular Graphics & Modelling
Annie C Bowles, Rachel M Wise, Brittany Y Gerstein, Robert C Thomas, Roberto Ogelman, Isabella Febbo, Bruce A Bunnell
The pathogenesis of many diseases is driven by the interactions between helper T (TH ) cells and macrophages. The phenotypes of these cells are a functional dichotomy that are persuaded according to the surrounding milieu. In both multiple sclerosis (MS) and the experimental autoimmune encephalomyelitis (EAE) model, TH 1 and TH 17 cells propagate autoimmune signaling and inflammation in the peripheral lymphoid tissues. In turn, this pro-inflammatory repertoire promotes the classical activation, formerly the M1-type, macrophages...
August 12, 2017: Stem Cells
Laura J Gardner, Morgan Ward, Robert H I Andtbacka, Kenneth M Boucher, Glen M Bowen, Tawnya L Bowles, Adam L Cohen, Kenneth Grossmann, Ying J Hitchcock, Sheri L Holmen, John Hyngstrom, Hung Khong, Martin McMahon, Marcus M Monroe, Carolyn B Ross, Gita Suneja, David Wada, Douglas Grossman
Melanoma metastasis to the brain is associated with a poor prognosis. We sought to determine patient demographics and primary tumor factors associated with the development of brain metastasis (BM) and survival. We also investigated whether the BM detection setting (routine screening vs. symptomatic presentation) affected clinical outcomes. A database of melanoma patients seen from 1999 to 2015 at our institution was reviewed to identify patients who developed BM. Patients with BM were matched by initial stage with patients who did not develop BM as a control group...
August 10, 2017: Melanoma Research
Damien Bazin, Chrystel Faure
We report the patterning of copper surfaces which display both superhydrophobicity and high adhesion thanks to a new feature geometry, and without resorting to chemical modification. Polystyrene beads organized in 2D crystals under an AC electric field act as a template for the growth of copper deposited via cupric ion-loaded multi-lamellar vesicles. After the removal of the beads, hexagonal arrays of supported hollow spheres or copper bowls are generated, depending on the amount of deposited copper. While the bowl-covered surfaces display a predictable decreasing wettability (Cassie model) as their wall height increases, the hollow sphere-covered surfaces exhibit both high adhesion and superhydrophobicity (Cassie-Baxter state)...
August 11, 2017: Soft Matter
Stephen Leong, Rebecca A Moss, Daniel W Bowles, Joseph A Ware, Jing Zhou, Jill M Spoerke, Mark R Lackner, Geetha Shankar, Jennifer L Schutzman, Ruud van der Noll, Emile E Voest, Jan H M Schellens
BACKGROUND: Epidermal growth factor receptor (EGFR) and phosphatidylinositol 3-kinase (PI3K) are involved in the proliferation and survival of many cancer types. Enhanced antitumor activity may be achieved through combined inhibition of these pathways. We report results for pictilisib (GDC-0941, a class I pan-PI3K inhibitor) plus erlotinib (an EGFR tyrosine kinase inhibitor) in patients with advanced solid tumors. MATERIALS AND METHODS: A 3 + 3 dose-escalation study was carried out at a starting daily dose of 60 mg pictilisib on days 1-21 of a 28-day cycle and 150 mg erlotinib from day 2 of cycle 1...
August 10, 2017: Oncologist
Elizabeth A DiNenno, Joseph Prejean, Kathleen Irwin, Kevin P Delaney, Kristina Bowles, Tricia Martin, Amrita Tailor, Gema Dumitru, Mary M Mullins, Angela B Hutchinson, Amy Lansky
CDC's 2006 recommendations for human immunodeficiency virus (HIV) testing state that all persons aged 13-64 years should be screened for HIV at least once, and that persons at higher risk for HIV infection, including sexually active gay, bisexual, and other men who have sex with men (MSM), should be rescreened at least annually (1). Authors of reports published since 2006, including CDC (2), suggested that MSM, a group that is at highest risk for HIV infection, might benefit from being screened more frequently than once each year...
August 11, 2017: MMWR. Morbidity and Mortality Weekly Report
Brian C Jensen, Scott J Bultman, Darcy Holley, Wei Tang, Gustaaf de Ridder, Salvatore Pizzo, Dawn Bowles, Monte S Willis
The cellular environment of the mammalian heart constantly is challenged with environmental and intrinsic pathological insults, which affect the proper folding of proteins in heart failure. The effects of damaged or misfolded proteins on the cell can be profound and result in a process termed "proteotoxicity". While proteotoxicity is best known for its role in mediating the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, its role in human heart failure also has been recognized. The UPR involves three branches, including PERK, ATF6, and IRE1...
2017: International Journal of Clinical and Experimental Medicine
Amit Gokhale, NurJehan Quraishy, Jennifer Royer, Heather Howdyshell, Lynn Murray, Linda Salmi, Viva Veemara, Kristin Ricci, Hien Liu
No abstract text is available yet for this article.
August 2017: Transfusion
S A Stuart, C M Wood, E S J Robinson
BACKGROUND AND PURPOSE: Predicting the risk of drug-induced adverse psychiatric effects is important but currently not possible in non-human species. This study has investigated whether the affective bias test (ABT) could provide a preclinical method with translational and predictive validity. EXPERIMENTAL APPROACH: The ABT is a bowl-digging task which quantifies biases associated with learning and memory. Rats encounter independent learning experiences, on separate days, under either acute manipulations (e...
August 7, 2017: British Journal of Pharmacology
Diane E Holland, Cheryl Brandt, Paul V Targonski, Kathryn H Bowles
PURPOSE OF STUDY: The Early Screen for Discharge Planning (ESDP) is a decision support tool developed in an urban academic medical center. High ESDP scores identify patients with nonroutine discharge plans who would benefit from early discharge planning intervention. We aimed to determine the predictive performance of the ESDP in a different practice setting. PRIMARY PRACTICE SETTING: Rural regional community hospital. METHODOLOGY AND SAMPLE: We designed a comparative, descriptive survey study and enrolled a convenience sample of 222 patients (identified at admission) who provided informed consent...
September 2017: Professional Case Management
M R J Morris, E Petrovitch, E Bowles, H A Jamniczky, S M Rogers
Coastal marine Gasterosteus aculeatus were captured from seven locations along the Pacific coast of North America, ranging across 21·8° latitude to test Jordan's rule, i.e. that vertebral number should increase with increasing latitude for related populations of fish. Vertebral number significantly increased with increasing latitude for both total and caudal vertebral number. Increasing length with latitude (sensu Bergmann's rule) was also supported, but the predictions for Jordan's rule held when controlling for standard length...
August 2017: Journal of Fish Biology
Quirin S Stöckl, Tsun-Cheng Wu, Anaïs Mairena, Yao-Ting Wu, Karl-Heinz Ernst
A 2D self-assembly of a C32H12 buckybowl on the Cu(111) surface has been studied by means of scanning tunnelling microscopy. Additional aromatic rings at the rim of the corannulene core cause the bowl-shaped molecule to stand on its edge. This adsorption mode allows distinct π-π and C-Hπ interactions between the convex bowl surfaces as well as between the hydrogen-terminated rim and the convex bowl faces.
August 3, 2017: Faraday Discussions
Chih-Hui Lo, Teh-Min Hu
The morphology of particles, along with other particle attributes, has been shown to affect the biological fate of particles administered into the body. Particles with collapsed surfaces or shells (dimpled, buckled or crumpled) can have different appearances, under the microscope, that resemble many things encountered in our daily life, such as apples/cherries, doughnuts, and bowls. Recent studies have demonstrated that they are not just particles with interesting geometries, but they can also be used as functional blocks for assembled complex materials...
August 3, 2017: Soft Matter
Mitra Tavakoli, Dilek Gogas Yavuz, Abd A Tahrani, Dinesh Selvarajah, Frank L Bowling, Hassan Fadavi
No abstract text is available yet for this article.
2017: Journal of Diabetes Research
Margaret Y Hwang, Seo Gyun Kim, Heon Sang Lee, Susan J Muller
Monodisperse particles of varying size, shape, and deformability were produced using two microfluidic strategies. For both strategies, monodisperse emulsion droplets of a crosslinkable solution were generated via flow-focusing. Subsequently, droplets were crosslinked either on chip or in an external bath. On-chip gelation resulted in spherical particles; varying the degree of crosslinking varied the deformability systematically. The optimized flow-focusing device design separated the production of monodisperse aqueous alginate droplets and the on-chip introduction of crosslinking ions...
August 2, 2017: Soft Matter
Qi Xu, Marina A Petrukhina, Andrey Yu Rogachev
The first comprehensive theoretical investigation of structural, energetic, and electronic changes in a sumanene skeleton, C21H12, upon a step-wise deprotonation process is performed. This study is complemented by a detailed consideration of aromaticity in target bowl-shaped systems, including neutral sumanene and its three deprotonated anions, namely C21H11(1-), C21H10(2-), and C21H9(3-). In order to obtain the most reliable and method-independent characteristics, a set of aromatic descriptors of different nature has been applied...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
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