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https://www.readbyqxmd.com/read/28338287/synthesis-of-rationally-halogenated-buckybowls-by-chemoselective-aromatic-c-f-bond-activation
#1
Olena Papaianina, Vladimir A Akhmetov, Alexey A Goryunkov, Frank Hampel, Frank W Heinemann, Konstantin Y Amsharov
Halogenated buckybowls or bowl-shaped polycyclic aromatic hydrocarbons (BS-PAHs) are key building blocks for the "bottom-up" synthesis of various carbon-based nanomaterials with outstanding potential in different fields of technology. The current state of the art provides quite a limited number of synthetic pathways to BS-PAHs; moreover, none of these approaches show high selectivity and tolerance of functional groups. Herein we demonstrate an effective route to BS-PAHs that includes directed intramolecular aryl-aryl coupling through C-F bond activation...
March 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28332256/hierarchical-corannulene-based-materials-energy-transfer-and-solid-state-photophysics
#2
Allison M Rice, W Brett Fellows, Ekaterina A Dolgopolova, Andrew B Greytak, Aaron K Vannucci, Mark D Smith, Stavros G Karakalos, Jeanette A Krause, Stanislav M Avdoshenko, Alexey A Popov, Natalia B Shustova
We report the first example of a donor-acceptor corannulene-containing hybrid material with rapid ligand-to-ligand energy transfer (ET). Additionally, we provide the first time-resolved photoluminescence (PL) data for any corannulene-based compounds in the solid state. Comprehensive analysis of PL data in combination with theoretical calculations of donor-acceptor exciton coupling was employed to estimate ET rate and efficiency in the prepared material. The ligand-to-ligand ET rate calculated using two models is comparable with that observed in fullerene-containing materials, which are generally considered for molecular electronics development...
March 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28327999/comprehensive-genomic-profiling-of-salivary-mucoepidermoid-carcinomas-reveals-frequent-bap1-pik3ca-and-other-actionable-genomic-alterations
#3
K Wang, J D McDermott, A B Schrock, J A Elvin, L Gay, S D Karam, D Raben, H Somerset, S M Ali, J S Ross, D W Bowles
Background: We sought to identify genomic alterations (GAs) in salivary mucoepidermoid carcinomas. Patients and methods: DNA was extracted from 48 mucoepidermoid carcinomas. Comprehensive genomic profiling (CGP) including the calculation to tumor mutational burden (TMB) was performed on hybridization-captured adaptor ligation-based libraries of 315 cancer-related genes plus introns from 28 genes frequently rearranged for cancer and evaluated for all classes of GAs...
January 16, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28324865/biomaterials-for-intervertebral-disc-regeneration-and-repair
#4
REVIEW
Robert D Bowles, Lori A Setton
The intervertebral disc contributes to motion, weight bearing, and flexibility of the spine, but is susceptible to damage and morphological changes that contribute to pathology with age and injury. Engineering strategies that rely upon synthetic materials or composite implants that do not interface with the biological components of the disc have not met with widespread use or desirable outcomes in the treatment of intervertebral disc pathology. Here we review bioengineering advances to treat disc disorders, using cell-supplemented materials, or acellular, biologically based materials, that provide opportunity for cell-material interactions and remodeling in the treatment of intervertebral disc disorders...
March 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28319523/plasma-levels-of-microrna-155-are-upregulated-with-long-term-left-ventricular-assist-device-support
#5
Teresa Wang, Emily C OʼBrien, Joseph G Rogers, Daniel L Jacoby, Michael E Chen, Jeffrey M Testani, Dawn E Bowles, Carmelo A Milano, G Michael Felker, Chetan B Patel, Pramod N Bonde, Tariq Ahmad
Left ventricular assist device (LVAD) therapy unloads the failing heart but exposes the human body to unique pathophysiological demands such as continuous blood-flow and complete univentricular support, which are associated with increased risk of adverse clinical outcomes. MiRNAs are 22-23 nucleotide RNAs involved in regulation of multiple biological processes including the pathogenesis of heart failure (HF). Thus, measurement of miRNAs may have potential in both diagnostics as circulating biomarkers, and in therapeutics for targeted interventions...
March 17, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28319378/computational-study-of-13-c-nmr-chemical-shift-anisotropy-patterns-in-c20h10-and-c20h10-4-insights-into-their-variation-upon-planarization-and-formation-of-concentric-aromatic-species-in-the-smaller-isolated-pentagon-structural-motif
#6
Alvaro Muñoz-Castro, Wilson Caimanque-Aguilar, Cesar Morales-Verdejo
Corannulene, C20H10, exhibits a concave surface in the ground state that is able to experience a bowl-to-bowl inversion through a planar conformation. Such a structure is the smaller example resembling an isolated-pentagon motif, as a relevant fragment in fullerene chemistry. Here, we explored the differences between bowl and planar conformations involving both energetic and (13)C NMR properties, for the neutral and tetraanionic species by using density functional theory (DFT) methods. This allows us to understand the variation of the chemical environment at the carbon atoms upon planarization of this representive motif...
March 24, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28318761/the-bone-marrow-microenvironment-home-of-the-leukemic-blasts
#7
REVIEW
Manar S Shafat, Bruno Gnaneswaran, Kristian M Bowles, Stuart A Rushworth
Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow (BM). Ex-vivo AML exhibits a high level of spontaneous apoptosis. Furthermore, relapse for patients achieving remission occurs from minimal residual disease harboured within the BM microenvironment. Taken together, these observations illustrate the importance of the BM microenvironment in sustaining AML...
March 12, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28318261/expanded-rosarin-a-versatile-fullerene-c60-receptor
#8
Xian-Sheng Ke, Taeyeon Kim, James T Brewster, Vincent M Lynch, Dongho Kim, Jonathan L Sessler
An expanded rosarian (P3P6) with a bowl-like conformation has been prepared and characterized. It is prepared in a one pot procedure that involves condensing a bispyrrole pyridine precursor (P1P2) with benzaldehyde, followed by oxidation. Single crystal X-ray diffraction analysis reveals a bowl-like conformation in the solid state with an upper rim diameter defined by the meso-phenyl substituents of ca. 13.5 Å and a depth of roughly 6.3 Å. P3P6 forms both 1:1 and 2:1 complexes with C60 in the solid state...
March 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28314926/american-football-and-fatal-exertional-heat-stroke-a-case-study-of-korey-stringer
#9
Andrew Grundstein, John A Knox, Jennifer Vanos, Earl R Cooper, Douglas J Casa
On August 1, 2001, Korey Stringer, a Pro Bowl offensive tackle for the Minnesota Vikings, became the first and to date the only professional American football player to die from exertional heat stroke (EHS). The death helped raise awareness of the dangers of exertional heat illnesses in athletes and prompted the development of heat safety policies at the professional, collegiate, and interscholastic levels. Despite the public awareness of this death, no published study has examined in detail the circumstances surrounding Stringer's fatal EHS...
March 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28301079/survival-impact-of-induction-chemotherapy-in-advanced-head-and-neck-cancer-a-national-cancer-database-analysis
#10
William A Stokes, Arya Amini, Bernard L Jones, Jessica D McDermott, David Raben, Debashis Ghosh, Julie A Goddard, Daniel W Bowles, Sana D Karam
BACKGROUND: Adding induction chemotherapy to concurrent chemotherapy and radiotherapy (RT) has generally not improved the overall survival (OS) in randomized trials of patients with head and neck cancer. This failure may stem from inadequate power or inappropriate patient selection, prompting this National Cancer Data Base analysis. METHODS: 8031 patients with T4 or N2b to N3 disease undergoing RT and chemotherapy were divided into induction chemotherapy and concurrent chemotherapy cohorts...
March 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28295911/co2-exchange-and-evapotranspiration-across-dryland-ecosystems-of-southwestern-north-america
#11
Joel A Biederman, Russell L Scott, Tom W Bell, David R Bowling, Sabina Dore, Jaime Garatuza-Payan, Thomas E Kolb, Praveena Krishnan, Dan J Krofcheck, Marcy E Litvak, Gregory E Maurer, Tilden P Meyers, Walter C Oechel, Shirley A Papuga, Guillermo E Ponce-Campos, Julio C Rodriguez, William K Smith, Rodrigo Vargas, Christopher J Watts, Enrico A Yepez, Michael L Goulden
Global-scale studies suggest that dryland ecosystems dominate an increasing trend in the magnitude and interannual variability of the land CO2 sink. However, such analyses are poorly constrained by measured CO2 exchange in drylands. Here we address this observation gap with eddy covariance data from 25 sites in the water-limited Southwest region of North America with observed ranges in annual precipitation of 100 - 1000 mm, annual temperatures of 2 - 25 °C, and records of 3 - 10 years (150 site-years in total)...
March 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28295138/frequency-and-risk-factors-for-live-discharge-from-hospice
#12
David Russell, Eli L Diamond, Bonnie Lauder, Ritchell R Dignam, Dawn W Dowding, Timothy R Peng, Holly G Prigerson, Kathryn H Bowles
OBJECTIVES: To report frequencies and associated risk factors for 4 distinct causes of live discharge from hospice. DESIGN: Retrospective cohort study using electronic medical records of hospice patients who received care from a large urban not-for-profit hospice agency in New York City during a 3-year period between 2013 and 2015 (n = 9,190). RESULTS: Roughly one in five hospice patients were discharged alive (21%; n = 1911). Acute hospitalization was the most frequent reason for live discharge (42% of all live discharges; n = 802)...
March 13, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28294240/pegylation-corannulene-enhances-response-of-stress-through-promoting-neurogenesis
#13
Xinyu Li, Dandan Sun, Xu Li, Dashuai Zhu, Zhenzhen Jia, Jiajia Jiao, Kai Wang, Deling Kong, Xin Zhao, Lin Xu, Qiang Zhao, Dongyan Chen, Xizeng Feng
Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene...
March 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28293204/what-are-the-ingredients-for-an-inequity-paradigm-manipulating-the-experimenter-s-involvement-in-an-inequity-task-with-dogs
#14
Désirée Brucks, Sarah Marshall-Pescini, Jennifer L Essler, Jim McGetrick, Ludwig Huber, Friederike Range
Cooperation is only beneficial if the outcome is equally shared between individuals involved in the cooperative interaction. A mechanism to limit the development of unequal cooperation is inequity aversion, the negative reaction to unequal treatment. While inequity aversion has been studied extensively across many animal species, it remains unclear whether inequity aversion elicited in experimental settings is directed to the cooperative partner animal or rather to the experimenter distributing the rewards unequally...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28290939/susceptibility-weighted-imaging-and-white-matter-abnormality-findings-in-service-members-with-persistent-cognitive-symptoms-following-mild-traumatic-brain-injury
#15
David F Tate, Maria Gusman, Jonathan Kini, Matthew Reid, Carmen S Velez, Ann Marie Drennon, Douglas B Cooper, Jan E Kennedy, Amy O Bowles, Erin D Bigler, Jeffrey D Lewis, John Ritter, Gerald E York
Mild traumatic brain injury (mTBI) is a major health concern among active duty service members and Veterans returning from combat operations, and it can result in variable clinical and cognitive outcomes. Identifying biomarkers that can improve diagnosis and prognostication has been at the forefront of recent research efforts. The purpose of this study was to compare the sensitivity and specificity of abnormalities identified using more traditional magnetic resonance imaging (MRI) sequences such as fluid attenuation inversion recovery (FLAIR) to more advanced MRI sequences such as susceptibility weighted imaging (SWI) among a cohort of active duty service members experiencing persistent cognitive symptoms after mTBI...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28288913/germ-cell-neoplasia-in-situ-the-precursor-cell-for-invasive-germ-cell-tumors-of-the-testis
#16
Cassy M Spiller, Josephine Bowles
Germ cell neoplasia in situ is the non-invasive precursor cell of origin for type II testicular germ cell tumors. It has long been postulated that germ cell neoplasia in situ is derived from defective germ cell development during embryonic life, and although it is impossible to trace in vivo the progression from fetal germ cell to germ cell neoplasia in situ to tumor, there is a large volume of evidence supporting this theory. Current studies focus on understanding how germ cell neoplasia in situ forms, how these cells are activated at puberty and how they transform to invasive tumors of various subtypes...
March 10, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28288139/mice-deleted-for-cell-division-cycle-73-gene-develop-parathyroid-and-uterine-tumours-model-for-the-hyperparathyroidism-jaw-tumour-syndrome
#17
G V Walls, M Stevenson, K E Lines, P J Newey, A A C Reed, M R Bowl, J Jeyabalan, B Harding, K J Bradley, S Manek, J Chen, P Wang, B O Williams, B T Teh, R V Thakker
The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malignant neoplasms. HPT-JT is caused by mutations of the cell division cycle 73 (CDC73) gene, located on chromosome 1q31.2 and encodes a 531 amino acid protein, parafibromin. To facilitate in vivo studies of Cdc73 in tumourigenesis we generated conventional (Cdc73(+/-)) and conditional parathyroid-specific (Cdc73(+/L)/PTH-Cre and Cdc73(L/L)/PTH-Cre) mouse models...
March 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28287054/effects-and-feasibility-of-an-exercise-intervention-for-individuals-living-with-dementia-in-nursing-homes-study-protocol
#18
Lindsey Brett, Victoria Traynor, Paul Stapley, Shahla Meedya
BACKGROUND: Worldwide, there are an estimated 35.6 million individuals living with dementia. It is important that non-pharmacological therapies are utilized to help manage the symptoms of dementia, such as agitation, as they are the recommended first approach in best practice guidelines. METHODS: This protocol outlines a randomized controlled trial with a qualitative component which evaluated the effects and feasibility of a physical therapist-led physical exercise intervention on agitation of individuals living with dementia in nursing homes...
March 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28286083/water-quality-compliance-and-health-outcomes-among-utilities-implementing-water-safety-plans-in-france-and-spain
#19
Karen E Setty, Georgia L Kayser, Michael Bowling, Jerome Enault, Jean-Francois Loret, Claudia Puigdomenech Serra, Jordi Martin Alonso, Arnau Pla Mateu, Jamie Bartram
Water Safety Plans (WSPs), recommended by the World Health Organization since 2004, seek to proactively identify potential risks to drinking water supplies and implement preventive barriers that improve safety. To evaluate the outcomes of WSP application in large drinking water systems in France and Spain, we undertook analysis of water quality and compliance indicators between 2003 and 2015, in conjunction with an observational retrospective cohort study of acute gastroenteritis incidence, before and after WSPs were implemented at five locations...
February 24, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28285472/liberating-the-oppressed-research-knowledge-differentials-and-ethical-investigation-in-special-operations-forces-clinical-science
#20
Kate Rocklein Kemplin, F Young Bowling
Special Operations Forces (SOF) medics do not have preparation in research knowledge that enables them to independently initiate or generate their own studies. Thus, medics rely on evidence generated by others, who are removed from medics' practice environment. Here, salient literature on research self-efficacy and the genesis of institutional review boards (IRBs) are reviewed and interpreted for contextual applications to medics' practice and initiation of studies. More publications delving into research methods are warranted to promote medics' participation and initiation of selfdirected scientific investigation, in collaboration with research scientists...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
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