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Atul Kabra, Rohit Sharma, Shivali Singla, Ruchika Kabra, Uttam Singh Baghel
BACKGROUND: Myrica esculenta (Family: Myricaceae) commonly known as Kaiphala or Katphala is a widely used medicinal plant in Ayurveda. In spite of its numerous medicinal attributes, no published work is available till date on pharmacognostical characterization and HPTLC analysis of its leaves. OBJECTIVES: To investigate the pharmacognostical, physicochemical, and HPTLC profiles of M. esculenta leaves. MATERIALS AND METHODS: The measures taken for pharmacognostical characterization were organoleptic study, macroscopy, microscopy, powder microscopy, leaf constant, fluorescence analysis, preliminary phytochemical screening and HPTLC spectra profile...
March 12, 2018: Journal of Ayurveda and Integrative Medicine
Gregory S Keenan, Louise Childs, Peter J Rogers, Marion M Hetherington, Jeffrey M Brunstrom
Large portion sizes lead to increased intake. Some studies suggest that individuals are unaware that they consume more when served larger portions. In a between-subjects design we asked female participants (N = 48) how much pasta and tomato sauce they intended to consume for lunch prior to eating. We then provided a smaller or a larger portion of the same food and invited participants to self-serve a portion into a second bowl (same size in both conditions). After eating until comfortably full, participants were shown an image of the amount they had selected at the beginning of the meal...
March 12, 2018: Appetite
Christopher J Lambert, Briana C Freshner, Arlen Chung, Tamara J Stevenson, D Miranda Bowles, Raheel Samuel, Bruce K Gale, Joshua L Bonkowsky
Zebrafish are a valuable model organism in biomedical research. Their rapid development, ability to model human diseases, utility for testing genetic variants identified from next-generation sequencing, amenity to CRISPR mutagenesis, and potential for therapeutic compound screening, has led to their wide-spread adoption in diverse fields of study. However, their power for large-scale screens is limited by the absence of automated genotyping tools for live animals. This constrains potential drug screen options, limits analysis of embryonic and larval phenotypes, and requires raising additional animals to adulthood to ensure obtaining an animal of the desired genotype...
2018: PloS One
Hiroki Yokoi, Satoru Hiroto, Hiroshi Shinokubo
The reversible formation of σ-bonds between organic radicals has been widely investigated. However, reports on the formation of σ-dimers from delocalized π-radical cations are scarce. Herein, we report the reversible σ-dimerization behavior of a bowl-shaped π-radical cation generated from a nitrogen-embedded buckybowl, both in the crystalline state and in solution. The detailed structure of the σ-dimer in the crystalline state was determined by a single-crystal X-ray diffraction analysis. The monomeric radical cation exists predominantly in solution at room temperature, while dimerization of the radical cations occurs through carbon-carbon σ-bond formation upon reducing the temperature...
March 15, 2018: Journal of the American Chemical Society
Annie C Bowles, Rachel M Wise, Brittany Y Gerstein, Robert C Thomas, Roberto Ogelman, Regan C Manayan, Bruce A Bunnell
BACKGROUND: The therapeutic efficacy of adipose-derived stem cells (ASCs) has been investigated for numerous clinical indications, including autoimmune and neurodegenerative diseases. Less is known using the crude adipose product called stromal vascular fraction (SVF) as therapy, although our previous studies demonstrated greater efficacy at late-stage disease compared to ASCs in the experimental autoimmune encephalomyelitis (EAE) mouse, a model of multiple sclerosis. In this study, SVF cells and ASCs were administered during the pathogenic progression, designated as early disease, to elucidate immunomodulatory mechanisms when high immune cell activities associated with autoimmune signaling occur...
March 13, 2018: Journal of Neuroinflammation
Morgan Bowling, Tyler Schmutzler, Sarah Glick
Mycoplasma pneumoniae is a frequent cause of childhood pneumonia, and extrapulmonary manifestations may be noted at the time of infection. While M. pneumoniae has long been associated with Stevens-Johnson syndrome, a separate diagnostic entity, Mycoplasma pneumoniae- induced rash and mucositis (MIRM), has recently been proposed to better characterize the rash and severe mucositis that some patients exhibit. A subset of patients with MIRM will have mucositis without skin rash. Physicians should recognize this clinical entity and be familiar with treatment options for MIRM...
March 2018: Clinical Case Reports
R Guerrero, C Qin, O Oktay, C Bowles, L Chen, R Joules, R Wolz, M C Valdés-Hernández, D A Dickie, J Wardlaw, D Rueckert
White matter hyperintensities (WMH) are a feature of sporadic small vessel disease also frequently observed in magnetic resonance images (MRI) of healthy elderly subjects. The accurate assessment of WMH burden is of crucial importance for epidemiological studies to determine association between WMHs, cognitive and clinical data; their causes, and the effects of new treatments in randomized trials. The manual delineation of WMHs is a very tedious, costly and time consuming process, that needs to be carried out by an expert annotator (e...
2018: NeuroImage: Clinical
Ann M Bowling, Rhonda Cooper, Ashley Kellish, Laura Kubin, Tedra Smith
INTRODUCTION: Direct patient care across the lifespan has been the standard for nursing clinical experiences over the past several years. Recently, the Ohio Board of Nursing ruled that 100% of pediatric clinical hours could be replaced with simulation. PURPOSE: Make a recommendation for the number of direct patient care clinical hours in pediatrics that are needed to meet the pediatric nursing competencies. METHOD: All fifty United States Boards of Nursing prelicensure nursing education requirements were reviewed to identify the number of required clinical hours and definitions for clinical experience...
March 2018: Journal of Pediatric Nursing
Joanne Hui Yee Lim, Jessica Hui Cheah Lim, Grace Hui Chin Lim, Bryan Lim, Maha Alkatib
No abstract text is available yet for this article.
March 9, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
W Toppen, W Suh, O Aksoy, P Benharash, C Bowles, R J Shemin, M Kwon
OBJECTIVE: With the introduction of the latest generation Sapien 3 transcatheter aortic valve, there has been a reduction in the usage of transapical (TA) approach for TAVRs in many centers. However, despite the smaller sheath size and more stream-lined delivery system, vascular complications continue to occur, especially in patients with peripheral vascular disease. Thus, our institution has maintained a stringent TA protocol aiming to prevent these complications. We hypothesize that this protocol has helped to reduce vascular complications and improve outcomes at our institution even in the Sapien 3 era...
March 6, 2018: Seminars in Thoracic and Cardiovascular Surgery
Brandon Bowling, David Newman, Craig White, Ashley Wood, Alberto Coustasse
Decreasing health care expenditures has been one of the main objectives of the Affordable Care Act. To achieve this goal, the Centers for Medicare and Medicaid Services (CMS) has been tasked with experimenting with provider reimbursement methods in an attempt to increase quality, while decreasing costs. The purpose of this research was to study the effects of the Affordable Care Act on physician reimbursement rates from CMS to determine the most cost-effective method of delivering health care services. The CMS has experimented with payment methods in an attempt to increase cost-effectiveness...
March 9, 2018: Health Care Manager
Jacob D Bolzenius, Benjamin S C Wade, Carmen S Velez, Ann Marie Drennon, Douglas B Cooper, Jan E Kennedy, Matthew W Reid, Amy O Bowles, Paul M Thompson, Boris Gutman, Jeffrey D Lewis, John L Ritter, Gerald E York, Erin D Bigler, David F Tate
OBJECTIVE: To assess interactions of subcortical structure with subjective symptom reporting associated with mild traumatic brain injury (mTBI), using advanced shape analysis derived from volumetric MRI. PARTICIPANTS: Seventy-six cognitively symptomatic individuals with mTBI and 59 service members sustaining only orthopedic injury. DESIGN: Descriptive cross-sectional study. MAIN MEASURES: Self-report symptom measures included the PTSD Checklist-Military, Neurobehavioral Symptom Inventory, and Symptom Checklist-90-Revised...
March 2018: Journal of Head Trauma Rehabilitation
Douglas B Cooper, Glenn Curtiss, Patrick Armistead-Jehle, Heather G Belanger, David F Tate, Matthew Reid, Amy O Bowles, Carmen S Velez, Jan E Kennedy, Rodney D Vanderploeg
OBJECTIVE: To examine differences in objective neurocognitive performance and subjective cognitive symptoms in individuals with a history of a single concussion, multiple concussions, orthopedic injuries, and posttraumatic stress disorder (PTSD). METHOD: Participants included 116 military service members who sustained a mild traumatic brain injury (mTBI) during combat deployment. Subjects were subdivided into groups based on concussion frequency: a single concussion (n = 42), 2 concussions (n = 21), and 3 or more concussions (n = 53)...
March 2018: Journal of Head Trauma Rehabilitation
Hua-Jin Zhai, Rui Li, Xue-Rui You, Kang Wang
Bowl-shaped C6v B36 cluster with a central hexagon hole is considered an ideal molecular model for low-dimensional boron-based nanosystems. Owing to electron-deficiency of boron, chemical bonding in B36 cluster is intriguing and complicated and has remained elusive despite a couple of papers in literature. Herein we shall offer an in-depth bonding analysis via canonical molecular orbitals (CMOs) and adaptive natural density partitioning (AdNDP), further aided with natural bond orbital (NBO) analysis and orbital composition calculations...
March 7, 2018: Chemistry, An Asian Journal
Maxime Garcia, Christian T Herbst, Daniel L Bowling, Jacob C Dunn, W Tecumseh Fitch
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
March 6, 2018: Scientific Reports
Laura C Plantinga, Raymond J Lynch, Rachel E Patzer, Stephen O Pastan, C Barrett Bowling
BACKGROUND AND OBJECTIVES: Serious fall injuries in the setting of ESKD may be associated with poor access to kidney transplant. We explored the burden of serious fall injuries among patients on dialysis and patients on the deceased donor waitlist and the associations of these fall injuries with waitlisting and transplantation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our analytic cohorts for the outcomes of ( 1 ) waitlisting and ( 2 ) transplantation included United States adults ages 18-80 years old who ( 1 ) initiated dialysis ( n =183,047) and ( 2 ) were waitlisted for the first time ( n =37,752) in 2010-2013...
March 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Alexandru-Dan Sabău, Noor Hassan, Cătălin Gabriel Smarandache, Alin Miheţiu, Ștefan Ţîţu, Dan Sabău
PURPOSE: An original technique using laparoscopic instruments in a gastric endocavitary work chamber with potential for esophagus, stomach and D1 vizualisation. The main purpose of laparagastroscopy is to improve the quality of life of the patient disabling by the esophageal tumor. This method has several advantages: providing physiological feeding, harvesting materials for histopathological examination, solving eso-tracheal fistulas concurrently with the proposed operation and hemostatic role through compression, low energy and plastic consumption, rapid socio-economic reintegration, mental psychological care of the patient...
January 2018: Chirurgia
Logan E Mitchell, John C Lin, David R Bowling, Diane E Pataki, Courtenay Strong, Andrew J Schauer, Ryan Bares, Susan E Bush, Britton B Stephens, Daniel Mendoza, Derek Mallia, Lacey Holland, Kevin R Gurney, James R Ehleringer
Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's metropolitan Salt Lake Valley. We examine "excess" CO2 above background conditions resulting from local emissions and meteorological conditions. We ascribe CO2 trends to changes in emissions, since we did not find long-term trends in atmospheric mixing proxies...
March 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
Irina V Chadaeva, Petr M Ponomarenko, Dmitry A Rasskazov, Ekaterina B Sharypova, Elena V Kashina, Dmitry A Zhechev, Irina A Drachkova, Olga V Arkova, Ludmila K Savinkova, Mikhail P Ponomarenko, Nikolay A Kolchanov, Ludmila V Osadchuk, Alexandr V Osadchuk
BACKGROUND: The progress of medicine, science, technology, education, and culture improves, year by year, quality of life and life expectancy of the populace. The modern human has a chance to further improve the quality and duration of his/her life and the lives of his/her loved ones by bringing their lifestyle in line with their sequenced individual genomes. With this in mind, one of genome-based developments at the junction of personalized medicine and bioinformatics will be considered in this work, where we used two Web services: (i) SNP_TATA_Comparator to search for alleles with a single nucleotide polymorphism (SNP) that alters the affinity of TATA-binding protein (TBP) for the TATA boxes of human gene promoters and (ii) PubMed to look for retrospective clinical reviews on changes in physiological indicators of reproductive potential in carriers of these alleles...
February 9, 2018: BMC Genomics
Marina A Petrukhina, Sarah Spisak, Alexander Zabula, Melisa Alkan, Alexander Filatov, Andrey Rogachev
Designed site-directed dimerization of the monoanion-radicals of a pi-bowl in the solid state is reported for the first time. Dibenzo[a,g]corannulene (C28H14) is selected for this work based on the asymmetry of the charge/spin localization in the C28H14*- anion. Controlled one-electron reduction of C28H14 with Cs metal in diglyme resulted in crystallization of a new dimer, [{Cs+(diglyme)}2(C28H14-C28H14)2-] (1), as revealed by single crystal X-ray diffraction study performed in a broad range of temperatures...
March 5, 2018: Angewandte Chemie
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