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https://www.readbyqxmd.com/read/28921774/modulating-vicarious-tactile-perception-with-transcranial-electrical-current-stimulation
#1
Natalie C Bowling, Michael J Banissy
Our capacity to share the experiences of others is a critical part of social behaviour. One process thought to be important for this is vicarious perception. Passively viewing touch activates some of the same network of brain regions as the direct experience of touch. This vicarious experience is usually implicit, but for some people, viewing touch evokes conscious tactile sensations (mirror-touch synaesthesia). Recent work has attempted to induce conscious vicarious touch in those that do not normally experience these sensations, using transcranial direct current stimulation (tDCS)...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28918511/the-role-of-major-virulence-factors-of-aiec-involved-in-inflammatory-bowl-disease-a-mini-review
#2
REVIEW
Yuqian Yang, Yuexia Liao, Yan Ma, Weijuan Gong, Guoqiang Zhu
Adherent-invasive Escherichia coli (AIEC) has recently attracted more attention because it is closely related to the pathogenicity of human inflammatory bowel disease (IBD). AIEC possesses a multitude of virulence factors. Considering these virulence factors belonging to various virulence groups, including adhesins, invasins, toxins, protectins, and siderophore-mediated iron acquisition, this review summarizes the current knowledge of how the major virulence factors assisting in AIEC survive in, adhere to, and invade host cells...
September 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28915134/vitamin-d-in-obesity
#3
Jennifer S Walsh, Simon Bowles, Amy L Evans
PURPOSE OF REVIEW: Vitamin D is essential for bone health, and may also have important functions in immunity and other systems. Vitamin D deficiency is common, and testing and supplementation is increasing. Serum vitamin D is lower in obese people; it is important to understand the mechanism of this effect and whether it indicates clinically significant deficiency. RECENT FINDINGS: Vitamin D is fat soluble, and distributed into fat, muscle, liver, and serum. All of these compartments are increased in volume in obesity, so the lower vitamin D likely reflects a volumetric dilution effect and whole body stores of vitamin D may be adequate...
September 14, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28912647/accelerometery-and-heart-rate-responses-of-professional-fast-medium-bowlers-in-one-day-and-multi-day-cricket
#4
James A Johnstone, Gerwyn Hughes, Andrew C Mitchell, Paul A Ford, Tim Watson, Rob Duffield, Dan Gordon, Justin D Roberts, Andrew T Garrett
The physical demands of fast-medium bowling are increasingly being recognised, yet comparative exploration of the differing demands between competitive formats (i.e. one-day [OD] versus multi-day [MD] matches) remain minimal. The aim of this study was to describe in-match physiological profiles of professional fast-medium bowlers from England across different versions of competitive matches using a multivariable wearable monitoring device. Seven professional cricket fast-medium bowlers wore the Bioharness(TM) monitoring device during matches, over three seasons (>80 hours in-match)...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28911205/a-zebrafish-model-of-x-linked-adrenoleukodystrophy-recapitulates-key-disease-features-and-demonstrates-a-developmental-requirement-for-abcd1-in-oligodendrocyte-patterning-and-myelination
#5
Lauren R Strachan, Tamara J Stevenson, Briana Freshner, Matthew D Keefe, D Miranda Bowles, Joshua L Bonkowsky
X-linked adrenoleukodystrophy (ALD) is a devastating inherited neurodegenerative disease caused by defects in the ABCD1 gene and affecting peripheral and central nervous system myelin. ABCD1 encodes a peroxisomal transmembrane protein required for very long chain fatty acid (VLCFA) metabolism. We show that zebrafish (Danio rerio) Abcd1 is highly conserved at the amino acid level with human ABCD1, and during development is expressed in homologous regions including the central nervous system and adrenal glands...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28910151/synthesis-positron-emission-tomography-imaging-and-therapy-of-diabody-targeted-drug-lipid-nanoparticles-in-a-prostate-cancer-murine-model
#6
Patty Wong, Lin Li, Junie Chea, Melissa K Delgado, Erasmus Poku, Barbara Szpikowska, Nicole Bowles, Megan Minnix, David Colcher, Jeffrey Y C Wong, John E Shively, Paul J Yazaki
The blood clearance of chemotherapeutic drugs such as doxorubicin (Dox) can be extended by incorporation into lipid nanoparticles (LNPs) and further improved by tumor targeting with antibody fragments. We used positron emission tomography (PET) imaging in a murine prostate cancer model to evaluate tumor targeting of LNPs incorporating Dox and antiprostate-specific membrane antigen (PSMA) diabodies. Dox-LNPs were generated by mixing or covalent attachment to water soluble distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG)2000...
September 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28906118/pauli-repulsion-versus-van-der-waals-interaction-of-indenocorannulene-with-a-cu-111-surface
#7
Laura Zoppi, Quirin S Stöckl, Anais Mairena, Oliver Allemann, Jay S Siegel, Kim K Baldridge, Karl-Heinz Ernst
Modification of metal electrode surfaces with functional organic molecules is an important step towards organic electronics. The interaction of the buckybowl indenocorannulene with a Cu(111) surface and the two-dimensional self-assembly on the same surface was studied by means of scanning tunneling microscopy and dispersion-enabled density functional theory. Based on the conjecture of maximizing van der Waals interaction with the surface one would expect the indeno group to be aligned parallel to the surface...
September 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28901772/electron-poor-bowl-shaped-polycyclic-aromatic-dicarboximides-synthesis-crystal-structures-and-optical-and-redox-properties
#8
Kazutaka Shoyama, David Schmidt, Magnus Mahl, Frank Würthner
Two new bowl-shaped polycyclic aromatic hydrocarbons, based on corannulene and naphthalene dicarboximide, are synthesized by an improved Suzuki-Miyaura cross-coupling and C-H arylation cascade reaction. Crystallographic analyses confirm structural assignments and provide insight into molecular interactions in the solid state. The new bowl-shaped molecules show reversible oxidation and reduction, intense visible range absorption, and high fluorescence quantum yields. These molecules can be considered bowl-shaped congeners of planar perylene dicarboximides...
September 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/28887739/an-evaluation-of-a-handheld-spectroradiometer-for-the-near-real-time-measurement-of-cyanobacteria-for-bloom-management-purposes
#9
Lee C Bowling, Mustak Shaikh, John Brayan, Tim Malthus
A commercially available handheld spectroradiometer, the WISP-3, was assessed as a tool for monitoring freshwater cyanobacterial blooms for management purposes. Three small eutrophic urban ponds which displayed considerable within-pond and between-pond variability in water quality and cyanobacterial community composition were used as trial sites. On-board algorithms provide field measurements of phycocyanin (CPC) and chlorophyll-a (Chl-a) from surface reflectance spectra measured by the instrument. These were compared with laboratory measurements...
September 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28887079/measuring-the-validation-of-assessing-the-non-dominant-hand-function-by-alsfrs-r-in-chinese-als-patients
#10
REVIEW
Fangfang Hu, Jiaoting Jin, Rui Jia, Li Xiang, Huaguang Qi, Xing Zhao, Jingxia Dang
ALSFRS-r is a widely accepted rating scale for measuring the global function of Amyotrophic Lateral Sclerosis (ALS) patients, but we found some limitations of ALSFRS-r in assessing the function of non-dominant hand in Chinese ALS patients. We reviewed 95 ALS patients who expressed upper-limb symptoms at first visit and analyzed the ALSFRS-r score and subscale. In both upper limb involved patients, the ALSFRS-r had no difference between dominant-hand and non-dominant-hand onset groups (39.15±5.55 vs 38.0±5...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885213/presentation-of-a-variation-of-the-chorioallantoic-membrane-set-up-as-a-potential-model-for-individual-therapy-for-squamous-cell-carcinoma-of-the-oropharynx
#11
P Kauffmann, M Troeltzsch, R Cordesmeyer, P I Heidekrueger, H Schliephake, M Canis, H A Wolff, M Rave-Fraenk, P Stroebel, A Kehrer, L Prantl, T Aung
The chorioallantoic membrane of fertilized chicken eggs in an early phase of breeding presents an approved test situation for the growth and treatment of human cancer cells.These models work due to the inoculation of cells into the membrane that stays within the egg shell during the time of investigation. In this study a modification of this model is presented. Samples of native tumors, rather than cell lines, are transplanted into the membrane and the body of the egg is taken out of the shell and placed in a plastic bowl...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28880170/rapid-spatial-mapping-of-focused-ultrasound-fields-using-a-planar-fabry-p%C3%A3-rot-sensor
#12
Eleanor Martin, Edward Z Zhang, James A Guggenheim, Paul C Beard, Bradley E Treeby
Measurement of high acoustic pressures is necessary in order to fully characterise clinical high-intensity focused ultrasound (HIFU) fields, and for accurate validation of computational models of ultrasound propagation. However, many existing measurement devices are unable to withstand the extreme pressures generated in these fields, and those that can often exhibit low sensitivity. Here, a planar Fabry-Pérot interferometer with hard dielectric mirrors and spacer was designed, fabricated, and characterised and its suitability for measurement of nonlinear focused ultrasound fields was investigated...
September 4, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28879571/risk-factors-for-non-contact-injury-in-adolescent-cricket-pace-bowlers-a-systematic-review
#13
REVIEW
Mitchell R L Forrest, Jeffrey J Hebert, Brendan R Scott, Stefano Brini, Alasdair R Dempsey
BACKGROUND: Adolescent cricket pace bowlers are prone to injury. Recognising the risk factors for non-contact injury in this population will aid future injury prevention strategies. OBJECTIVE: To identify the risk factors for non-contact injury in adolescent cricket pace bowlers. METHODS: We systematically searched PubMed, Cochrane Library, PEDro, SPORTDiscus, Embase, and the South African Journal of Sports Medicine to identify all experimental and observational studies reporting risk factors for non-contact injuries in pace bowlers (aged 12-19 years)...
September 6, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28878892/laparoscopic-and-open-inguinal-hernia-repair-patient-reported-outcomes-in-the-elderly-from-a-single-centre-a-prospective-cohort-study
#14
K Bowling, S El-Badawy, E Massri, J Rait, J Atkinson, S Leong, A Stuart, G Srinivas
BACKGROUND: With those over 65 making up over 16% of the UK's population, surgeons are counselling increasing numbers of elderly patients for hernia repair. Data is currently lacking comparing different repair methods of inguinal hernias in the elderly population with regards to patient reported outcomes. AIM: To compare open and laparoscopic hernia repair in patients >65 years old and those <65 years old with respect to patient reported outcomes. METHOD: As part of a quality assurance process patients receive a telephone consultation day 2 post procedure...
October 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28878120/mdm2-regulates-cardiac-contractility-by-inhibiting-grk2-mediated-desensitization-of-%C3%AE-adrenergic-receptor-signaling
#15
Pierre-Yves Jean-Charles, Samuel Mon-Wei Yu, Dennis Abraham, Reddy Peera Kommaddi, Lan Mao, Ryan T Strachan, Zhu-Shan Zhang, Dawn E Bowles, Leigh Brian, Jonathan A Stiber, Stephen N Jones, Walter J Koch, Howard A Rockman, Sudha K Shenoy
The oncoprotein Mdm2 is a RING domain-containing E3 ubiquitin ligase that ubiquitinates G protein-coupled receptor kinase 2 (GRK2) and β-arrestin2, thereby regulating β-adrenergic receptor (βAR) signaling and endocytosis. Previous studies showed that cardiac Mdm2 expression is critical for controlling p53-dependent apoptosis during early embryonic development, but the role of Mdm2 in the developed adult heart is unknown. We aimed to identify if Mdm2 affects βAR signaling and cardiac function in adult mice...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28874852/acoustic-allometry-revisited-morphological-determinants-of-fundamental-frequency-in-primate-vocal-production
#16
Maxime Garcia, Christian T Herbst, Daniel L Bowling, Jacob C Dunn, W Tecumseh Fitch
A fundamental issue in the evolution of communication is the degree to which signals convey accurate ("honest") information about the signaler. In bioacoustics, the assumption that fundamental frequency (f o) should correlate with the body size of the caller is widespread, but this belief has been challenged by various studies, possibly because larynx size and body size can vary independently. In the present comparative study, we conducted excised larynx experiments to investigate this hypothesis rigorously and explore the determinants of f o...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867424/psychosocial-and-behavioral-factors-in-acetaminophen-related-acute-liver-failure-and-liver-injury
#17
Carla Pezzia, Corron Sanders, Suzanne Welch, Angela Bowling, William M Lee
OBJECTIVES: Acetaminophen overdoses result in nearly 500 deaths annually and a much larger number of hospitalizations. Suicidal overdoses are exceeded in number in the United States by unintentional overdoses. We evaluated clinical, demographic and psychosocial factors among unintentional and intentional overdose patients whose acetaminophen (APAP) toxicity had resulted in acute liver failure. We hypothesized that APAP overdose patients would be more likely to suffer from behavioral health issues and display higher impulsivity scores than the general population...
October 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28862782/mycorrhizal-fungi-enhance-plant-nutrient-acquisition-and-modulate-nitrogen-loss-with-variable-water-regimes
#18
Timothy M Bowles, Louise E Jackson, Timothy R Cavagnaro
Climate change will alter both the amount and pattern of precipitation and soil water availability, which will directly affect plant growth and nutrient acquisition, and potentially, ecosystem functions like nutrient cycling and losses as well. Given their role in facilitating plant nutrient acquisition and water stress resistance, arbuscular mycorrhizal (AM) fungi may modulate the effects of changing water availability on plants and ecosystem functions. The well-characterized mycorrhizal tomato (Solanum lycopersicum L...
September 1, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28859730/a-multi-method-study-of-health-behaviours-and-perceived-concerns-of-sexual-minority-females-in-mumbai-india
#19
Jessamyn Bowling, Brian Dodge, Swagata Banik, Elizabeth Bartelt, Shruta Rawat, Lucia Guerra-Reyes, Devon Hensel, Debby Herbenick, Vivek Anand
Background: This multi-method study explores the perceived health status and health behaviours of sexual minority (i.e. self-identifying with a sexual identity label other than heterosexual) females (i.e. those assigned female at birth who may or may not identify as women) in Mumbai, India, a population whose health has been generally absent in scientific literature. Methods: Using community-based participatory research approaches, this study is a partnership with The Humsafar Trust (HST). HST is India's oldest and largest LGBT-advocacy organisation...
September 1, 2017: Sexual Health
https://www.readbyqxmd.com/read/28855743/asteroid-surface-impact-sampling-dependence-of-the-cavity-morphology-and-collected-mass-on-projectile-shape
#20
Bin Cheng, Yang Yu, Hexi Baoyin
In-situ exploration and remote thermal infrared observation revealed that a large fraction of Solar System small bodies should be covered with granular regolith. The complex and varied geology of the regolith layer may preserve the historical records of the surface modification and topographic evolution experienced by asteroids, especially cratering processes, in which the projectile shape plays a crucial role. Regarding the impact sampling scheme, the projectile-shape dependence of both the cavity morphology and the collected mass remains to be explored...
August 30, 2017: Scientific Reports
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