keyword
https://read.qxmd.com/read/38474063/transcriptomic-analyses-and-experimental-validation-identified-immune-related-lncrna-mrna-pair-mir210hg-bpifc-regulating-the-progression-of-hypertrophic-cardiomyopathy
#21
JOURNAL ARTICLE
Yuan Zhang, Jiuxiao Zhao, Qiao Jin, Lenan Zhuang
Hypertrophic cardiomyopathy (HCM) is a disease in which the myocardium of the heart becomes asymmetrically thickened, malformed, disordered, and loses its normal structure and function. Recent studies have demonstrated the significant involvement of inflammatory responses in HCM. However, the precise role of immune-related long non-coding RNAs (lncRNAs) in the pathogenesis of HCM remains unclear. In this study, we performed a comprehensive analysis of immune-related lncRNAs in HCM. First, transcriptomic RNA-Seq data from both HCM patients and healthy individuals (GSE180313) were reanalyzed thoroughly...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38470401/changes-in-weight-or-body-composition-by-frailty-status-a-pilot-study
#22
JOURNAL ARTICLE
Hillary B Spangler, David H Lynch, Danae C Gross, Summer B Cook, John A Batsis
Weight loss may benefit older adults with obesity. However, it is unknown whether individuals with different frailty phenotypes have different outcomes following weight loss. Community-dwelling adults aged ≥65 ( n  = 53) with a body mass index ≥30 kg/m2 were recruited for a six-month, single-arm, technology-based weight loss study. A 45-item frailty index identified frailty status using subjective and objective measures from a baseline geriatric assessment. At baseline, n  = 22 participants were classified as pre-frail (41...
March 12, 2024: Journal of Nutrition in Gerontology and Geriatrics
https://read.qxmd.com/read/38468241/efficacy-and-safety-of-orlistat-in-male-patients-with-overweight-obesity-and-hyperuricemia-results-of-a-randomized-double-blind-placebo-controlled-trial
#23
JOURNAL ARTICLE
Shuang Liu, Xiaojing Lin, Minghao Tao, Qi Chen, Hang Sun, Yali Han, Shaoling Yang, Yining Gao, Shen Qu, Haibing Chen
BACKGROUND: Obesity is associated with elevated serum uric acid (SUA) levels and frequent gout flares. Losing weight can reduce the SUA level and gout flares. The effect of orlistat on SUA levels and gout flares in patients with overweight/obesity and hyperuricemia (HUA) has not been extensively studied. This study investigated the effects of orlistat on SUA levels and gout flares compared to placebo in overweight and obese patients with HUA. METHODS: A total of 72 Chinese patients with overweight/obesity and HUA were randomly divided into a placebo group (35, 48...
March 11, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38459568/differentiating-anorexia-nervosa-and-atypical-anorexia-nervosa-with-absolute-weight-cut-offs-results-in-a-skewed-distribution-for-premorbid-weight-among-youth
#24
JOURNAL ARTICLE
Abigail Matthews, Jessica Lin, Grace Jhe, Triinu Peters, Leslie Sim, Johannes Hebebrand
OBJECTIVE: Anorexia nervosa (AN) and atypical AN are conceptualized as distinct illnesses, despite similar characteristics and sequelae. Whereas DSM-5 differentiates youth with AN and atypical AN by the presence of clinical 'underweight' (i.e., 5th BMI percentile for age-and-sex (BMI%)), we hypothesized that using this weight cut-off to discern diagnoses creates a skewed distribution for premorbid weight. METHOD: Participants included hospitalized youth with AN (n = 165, 43...
March 8, 2024: International Journal of Eating Disorders
https://read.qxmd.com/read/38453252/assessing-the-efficacy-of-curcumin-loaded-alginate-hydrogel-on-skin-wound-healing-a-gene-expression-analysis
#25
JOURNAL ARTICLE
Sepehr Zamani, Majid Salehi, Arian Ehterami, Mh Busra Fauzi, Ghasem Abbaszadeh-Goudarzi
Skin tissue engineering has gained significant attention as a promising alternative to traditional treatments for skin injuries. In this study, we developed 3D hydrogel-based scaffolds, Alginate, incorporating different concentrations of Curcumin and evaluated their properties, including morphology, swelling behavior, weight loss, as well as hemo- and cytocompatibility. Furthermore, we investigated the therapeutic potential of Alginate hydrogel containing different amounts of Curcumin using an in vitro wound healing model...
March 7, 2024: Journal of Biomaterials Applications
https://read.qxmd.com/read/38453059/the-association-between-patterns-of-weight-change-diabetes-status-and-glycaemia-among-adults-with-overweight-and-obesity
#26
JOURNAL ARTICLE
Ruoyu Yin, Amy L Ahern, Louise Lafortune, Simon J Griffin, Jean M Strelitz, Julia Mueller
AIMS: To investigate the associations between weight change patterns and 5-year incident non-diabetic hyperglycaemia (NDH), and glycated haemoglobin (HbA1c ) levels among individuals who had overweight or obesity. METHODS: This longitudinal cohort study (N = 435) pooled data from a weight management trial. Participants were adults with a BMI of ≥28 kg/m2 . They were categorised as "no weight loss", "maintainers", and "regainers" based on their weight at 3 months and 12 months after baseline...
March 5, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38443200/pre-surgical-factors-related-to-latent-trajectories-of-5-year-weight-loss-for-a-diverse-bariatric-surgery-population
#27
JOURNAL ARTICLE
Ernest Shen, Aileen Baecker, Ming Ji, Sonya Negriff, Silvia R Paz, Bhumi B Bhakta, Cecelia L Crawford, Adam Drewnowski, Kristina H Lewis, Darren D Moore, Sameer B Murali, Deborah R Young, Karen J Coleman
BACKGROUND: Analyzing trajectories of weight loss may address how particular groups of patients respond to metabolic and bariatric surgery. OBJECTIVES: The Bariatric Experience Long Term (BELONG) study was designed to use a theoretical model to examine determinants of weight loss and recurrence. SETTING: Large integrated health system in Southern California with 11 surgical practices and 23 surgeons. METHODS: A total of n = 1338 patients who had metabolic and bariatric surgery were surveyed before surgery to measure factors related to median percent total weight loss (%TWL) over 5 years...
February 1, 2024: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/38438635/black-veterans-experiences-with-and-recommendations-for-improving-weight-related-health-care-a-photovoice-study
#28
JOURNAL ARTICLE
Jessica Y Breland, Lamont Tanksley, Michelle A Borowitz, Dakota Houseknecht, Na'imah Muhammad, Susan D Raffa, Katherine D Hoerster
BACKGROUND: Non-Hispanic Black or African American (hereafter Black) veterans lose less weight than other users of the Veterans Health Administration's (VHA) weight management program (MOVE!), despite higher enrollment. OBJECTIVE: To understand factors that affect weight loss disparities between Black veterans and other veterans. DESIGN: Qualitative study using Photovoice methods. PARTICIPANTS: Self-identified Black veterans in MOVE! across the USA (two women, seven men)...
March 4, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38429842/what-could-be-the-reasons-for-not-losing-weight-even-after-following-a-weight-loss-program
#29
REVIEW
Jyoti Dabas, S Shunmukha Priya, Akshay Alawani, Praveen Budhrani
INTRODUCTION: Approximately four million people worldwide die annually because of obesity. Weight loss is commonly recommended as a first-line therapy in overweight and obese patients. Although many individuals attempt to lose weight, not everyone achieves optimal success. Few studies point out that weight loss eventually slows down, stagnates or reverses in 85% of the cases. RESEARCH QUESTION: What could be the reasons for not losing weight even after following a weight loss program? METHODS: A scoping review of the literature was performed using weight loss-related search terms such as 'Obesity,' 'Overweight,' 'Lifestyle,' 'weight loss,' 'Basal Metabolism,' 'physical activity,' 'adherence,' 'energy balance,' 'Sleep' and 'adaptations...
March 2, 2024: Journal of Health, Population, and Nutrition
https://read.qxmd.com/read/38425396/systemic-inflammation-response-index-and-weight-loss-as-prognostic-factors-in-metastatic-pancreatic-cancer-a-concept-study-from-the-pantheia-seom-trial
#30
JOURNAL ARTICLE
Vilma Pacheco-Barcia, Sara Custodio-Cabello, Fatima Carrasco-Valero, Magda Palka-Kotlowska, Axel Mariño-Mendez, Alberto Carmona-Bayonas, Javier Gallego, A J Muñoz Martín, Paula Jimenez-Fonseca, Luis Cabezon-Gutierrez
BACKGROUND: The prognostic value of the Systemic Inflammation Response Index (SIRI) in advanced pancreatic cancer is recognized, but its correlation with patients´ nutritional status and outcomes remains unexplored. AIM: To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer. METHODS: The PANTHEIA-Spanish Society of Medical Oncology (SEOM) study is a multicentric (16 Spanish hospitals), observational, longitudinal, non-interventional initiative, promoted by the SEOM Real World-Evidence work group...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38423496/the-association-between-brominated-flame-retardants-exposure-with-bone-mineral-density-in-us-adults-a-cross-sectional-study-of-the-national-health-and-nutrition-examination-survey-nhanes-2005-2014
#31
JOURNAL ARTICLE
Tianyu Bai, Xiangjun Li, Han Zhang, Wenkang Yang, Changlin Lv, Xiaofan Du, Shiqi Xu, Aiping Zhao, Yongming Xi
BACKGROUND AND AIMS: Exposure to brominated flame retardants (BFRs) has been widely confirmed to impair the normal functioning of the human body system. However, there is a paucity of study on the effects of serum BFRs on bone mineral density (BMD). This study aims to investigate the relationship between exposure to BFRs and BMD in a nationally representative sample of U.S. adults. METHODS: 3079 participants aged between 20 and 80 years with complete data were included in the study...
February 27, 2024: Environmental Research
https://read.qxmd.com/read/38418491/understanding-social-dynamics-and-patient-experience-in-out-of-hospital-care-validation-of-a-co-responsibility-questionnaire-corecare
#32
JOURNAL ARTICLE
Melanie Knufinke-Meyfroyt, Carlo Lancia, Yentl Lodewijks, Simon Nienhuijs, Eva Deckers
Patient experiences are commonly assessed through patient reported experience measures (PREMs). Ambulatory care models extend traditional care into the patients' home, meaning that a triangle of health care professionals, patients, and their families need to be considered when assessing the remote care experience. These intertwined responsibilities are described by co-responsibility. Currently, PREMs don't reflect how elements to remote care impact this remote care experience. Therefore, this study aimed to develop a questionnaire assessing perceived patient-partner co-responsibility as a PREM in remote care...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38409701/drug-target-affinity-prediction-by-molecule-secondary-structure-representation-network
#33
JOURNAL ARTICLE
Yuewei Tang, Yunhai Li, Pengpai Li, Zhi-Ping Liu
INTRODUCTION: Identification of drug-target interactions (DTI) is a crucial step in drug development with high specificity and low toxicity. To accelerate the process, computer-aided DTI prediction algorithms have been used to screen compounds or targets rapidly. Furthermore, DTI prediction can be used to identify potential targets for existing drugs, thus uncovering new indications and repositioning them. Therefore, it is of great importance to develop efficient and accurate DTI prediction algorithms...
February 22, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38407494/an-efficient-and-fast-method-for-labeling-and-analyzing-mouse-glomeruli
#34
JOURNAL ARTICLE
Lin Bai, Yaping Wu, Wenshu Dai, Qiuxiao Shi, Lei Wu, Jie Zhang, Lily Zheng
The glomeruli are fundamental units in the kidney; hence, studying the glomeruli is pivotal for understanding renal function and pathology. Biological imaging provides intuitive information; thus, it is of great significance to label and observe the glomeruli. However, the glomeruli observation methods currently in use require complicated operations, and the results may lose label details or three-dimensional (3D) information. The clear, unobstructed brain imaging cocktails and computational analysis (CUBIC) tissue clearing technology has been widely used in renal research, allowing for more accurate detection and deeper detection depth...
February 9, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38407195/assessment-and-management-of-patients-with-obesity-and-hypertension-in-european-society-of-hypertension-excellence-centres-a-survey-from-the-esh-working-group-on-diabetes-and-metabolic-risk-factors
#35
JOURNAL ARTICLE
Christina Antza, Guido Grassi, Thomas Weber, Alexandre Persu, Jens Jordan, Peter M Nilsson, Josep Redon, Stella Stabouli, Reinhold Kreutz, Vasilios Kotsis
BACKGROUND: Healthcare providers are faced with an increasing number of patients with obesity and arterial hypertension. Preventing obesity-associated hypertension and appropriately managing patients with established disease are both important. Hence, the aim of our study was to evaluate the clinical care of patients with obesity and hypertension among ESH Excellence Centres (ECs). METHODS: We conducted a cross-sectional, international 30-item survey through e-mails...
December 2024: Blood Pressure
https://read.qxmd.com/read/38403079/does-your-patient-need-to-lose-weight-weight-change-before-and-after-total-hip-arthroplasty-does-not-affect-healthcare-utilization-and-achievement-of-the-minimal-clinically-important-difference
#36
JOURNAL ARTICLE
Joshua L Tidd, Pedro Rullán, Precious Oyem, Matthew Hadad, Ignacio Pasqualini, Nickelas Huffman, Alison K Klika, Nicolas S Piuzzi
BACKGROUND: Despite the potential negative impact of preoperative obesity on THA outcomes, the association between preoperative and postoperative weight change and outcomes is much less understood. Therefore, this study aimed to determine the impact of pre- and postoperative weight change and preoperative body mass index (BMI) on healthcare utilization, satisfaction, and achievement of minimal clinically important difference (MCID) for Hip disability and Osteoarthritis Outcome Score Physical Function Short-Form (HOOS PS) and HOOS Pain...
February 23, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38402411/factors-associated-with-prospective-changes-in-weight-control-intentions-among-adolescents
#37
JOURNAL ARTICLE
Kristen M Lucibello, Mahmood R Gohari, Scott T Leatherdale, Karen A Patte
INTRODUCTION: The present study examined predictors of negative changes in weight control intentions from before to during the COVID-19 pandemic among adolescents. METHODS: Participants were Canadian secondary school students enrolled in the COMPASS study and had completed self-report surveys before (T1; 2018/2019 and/or 2019/2020 school year) and during (T2; 2020/2021 and/or 2021/2022) the COVID-19 pandemic (N = 11,869, Mage  ± SD = 13...
February 24, 2024: Journal of Adolescence
https://read.qxmd.com/read/38397344/the-role-of-skin-to-skin-contact-and-breastfeeding-in-the-first-hour-post-delivery-in-reducing-excessive-weight-loss
#38
JOURNAL ARTICLE
Valentina Jurgelėnė, Vilma Kuzmickienė, Dalia Stonienė
BACKGROUND AND AIMS: An excessive weight loss (EWL) of >10% after birth is associated with serious health outcomes. The aim of this study was to determine factors that can reduce weight loss in full-term, exclusively breastfed infants after birth. METHODS: This is a retrospective, observational, single-center study. We included 642 healthy, full-term, exclusively breastfed neonates born in 2019 in a baby-friendly hospital, and their healthy mothers. The exclusion criteria were as follows: supplementation with formula, multiple pregnancies, and neonates or mothers with health issues...
February 10, 2024: Children
https://read.qxmd.com/read/38393861/implemented-classification-techniques-for-osteoporosis-using-deep-learning-from-the-perspective-of-healthcare-analytics
#39
JOURNAL ARTICLE
Lili Liu
BACKGROUND: Osteoporosis is a medical disorder that causes bone tissue to deteriorate and lose density, increasing the risk of fractures. Applying Neural Networks (NN) to analyze medical imaging data and detect the presence or severity of osteoporosis in patients is known as osteoporosis classification using Deep Learning (DL) algorithms. DL algorithms can extract relevant information from bone images and discover intricate patterns that could indicate osteoporosis. OBJECTIVE: DCNN biases must be initialized carefully, much like their weights...
February 4, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38393021/the-efficacy-of-lactobacillus-delbrueckii-ssp-bulgaricus-supplementation-in-managing-body-weight-and-blood-lipids-of-people-with-overweight-a-randomized-pilot-trial
#40
JOURNAL ARTICLE
Pei-Yi Chu, Ying-Chun Yu, Yi-Cheng Pan, Yun-Hao Dai, Juan-Cheng Yang, Kuo-Chin Huang, Yang-Chang Wu
This study aimed to evaluate the efficacy of Lactobacillus delbrueckii ssp. bulgaricus ( L. bulgaricus ) in improving body weight, obesity-related outcomes, and lipid profiles of overweight people. Thirty-six overweight participants were randomly assigned to either a probiotic or a placebo group. A placebo powder or L. bulgaricus powder (containing 1 × 108 colony-forming unit (CFU) of the probiotic) was administered daily for 12 weeks. Body composition was determined, and blood tests were performed before and after the intervention...
February 16, 2024: Metabolites
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